MCID: BNG002
MIFTS: 31

Benign Meningioma

Categories: Cancer diseases, Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 52 14 69
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 42 D008579
NCIt 47 C4055
UMLS 69 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to meningioma, familial and verruciform xanthoma of skin. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Hydroxyurea and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain and lung, and related phenotypes are Increased cell death HMECs cells and Increased Nanog expression

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 meningioma, familial 10.9
2 verruciform xanthoma of skin 10.6 NF2 PGR
3 cauda equina neoplasm 10.6 EPB41L3 NF2
4 intraductal breast myoepitheliosis 10.6 NF2 PGR
5 epilepsy, familial focal, with variable foci 1 10.6 EPB41L3 NF2
6 central nervous system germ cell tumor 10.6 NF2 PGR
7 diphtheria 10.5 NF2 PGR
8 epidural abscess 10.5 NF2 PGR
9 anovulation 10.5 NF2 TERT
10 central nervous system tuberculosis 10.5 MKI67 PGR
11 bladder colloid adenocarcinoma 10.5 MKI67 PGR
12 pseudounicornuate uterus 10.5 MKI67 PGR
13 rectal neoplasm 10.5 MKI67 PGR
14 toxic pneumonitis 10.4 EPB41L3 NF2
15 trachea sarcoma 10.4 PGR TERT
16 clear cell ependymoma 10.4 EPB41L3 NF2
17 sparse hair ptosis mental retardation 10.4 MKI67 TERT
18 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.3 BIRC5 NF2
19 pericardial tuberculosis 10.3 EPB41L3 TERT
20 epidermolysa bullosa simplex with muscular dystrophy 10.3 MKI67 NF2
21 nutmeg liver 10.3 CTSL TERT
22 ovarian mesodermal adenosarcoma 10.3 BIRC5 PGR
23 vestibular gland benign neoplasm 10.2 NF2 PGR
24 acute allergic mucoid otitis media 10.2 CTSL TERT
25 pulmonary valve disease 10.2 BIRC5 PGR
26 breast duct papilloma 10.2 MKI67 PGR
27 tenosynovitis of foot and ankle 10.1 BIRC5 PGR
28 oral antidiabetic drugs toxicity or dose selection 10.1 BIRC5 MKI67
29 lymphocytic infiltrate of jessner 10.1 PCNA PGR
30 leiomyoma cutis 10.1 PCNA PGR
31 endometriosis of uterus 10.1 MKI67 PGR
32 gastric adenocarcinoma 10.0 MKI67 PCNA
33 boylan dew greco syndrome 10.0 MKI67 PCNA
34 leiomyoma 10.0 NF2 PCNA
35 orbital lymphoma 10.0 MKI67 PCNA
36 rare endometriosis 10.0 BIRC5 TERT
37 esophagus sarcoma 10.0 PCNA PGR
38 childhood oligodendroglioma 10.0 MKI67 PCNA
39 tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria 9.9 PCNA PGR
40 levy-yeboa syndrome 9.9 MKI67 PCNA
41 serous cystadenocarcinoma 9.9 BIRC5 PGR
42 charcot-marie-tooth disease type 2a 9.8 BIRC5 MKI67 TERT
43 brain edema 9.8
44 laryngeal adenoid cystic carcinoma 9.8 MKI67 PCNA
45 connective tissue cancer 9.6 NF2 PCNA
46 cervical cancer, somatic 9.6 MKI67 PCNA TERT
47 cerebral amyloid angiopathy 9.6
48 cerebritis 9.6
49 histiocytoma 9.6
50 fibrous histiocytoma 9.6

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.26 BIRC5 CTSL PCNA PGR
2 Increased Nanog expression GR00371-A-1 9.02 BIRC5 MKI67 PCNA
3 Increased Nanog expression GR00371-A-3 9.02 BIRC5
4 Increased Nanog expression GR00371-A-5 9.02 BIRC5

MGI Mouse Phenotypes related to Benign Meningioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 BIRC5 EPB41L3 NF2 PCNA PGR TERT
2 normal MP:0002873 9.1 BIRC5 EPB41L3 HSD17B13 MKI67 PGR TERT

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2 Nucleic Acid Synthesis Inhibitors Phase 2
3 Anti-Infective Agents Phase 2
4 Antiviral Agents Phase 2
5 Interferon-alpha Phase 2
6 interferons Phase 2
7 Iron-Dextran Complex Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
2 Proton/Photon Rt - Benign Meningiomas(P92-13) Completed NCT02947984 Phase 3
3 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
4 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2 hydroxyurea
5 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
6 Multisession Radiosurgery for Optic Nerve Sheath Meningiomas Recruiting NCT02594709 Phase 2
7 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127
8 Stereotactic Body Radiotherapy for Spine Tumors Active, not recruiting NCT01347307

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

39
Brain, Lung

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show all 44)
id Title Authors Year
1
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. ( 27815026 )
2017
2
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. ( 27284345 )
2016
3
Review of controversies in management of non-benign meningioma. ( 27338209 )
2016
4
A case of benign meningioma presented with subdural hemorrhage. ( 25977904 )
2015
5
Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma. ( 26385916 )
2015
6
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. ( 24751409 )
2014
7
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. ( 24813096 )
2014
8
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. ( 23840654 )
2013
9
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. ( 22285662 )
2012
10
Impaired survival and long-term neurological problems in benign meningioma. ( 22406926 )
2012
11
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. ( 23285163 )
2012
12
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. ( 22420586 )
2012
13
Is a benign meningioma always an indolent tumor? ( 21486754 )
2011
14
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. ( 20428925 )
2010
15
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. ( 20819539 )
2010
16
Benign meningioma developing late lung metastases: case report and review of the literature. ( 19919820 )
2009
17
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. ( 21509301 )
2009
18
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. ( 19122989 )
2008
19
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. ( 18586307 )
2008
20
Gamma Knife surgery for benign meningioma. ( 17695387 )
2007
21
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? ( 17961045 )
2007
22
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. ( 15980114 )
2006
23
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. ( 16465773 )
2006
24
PCNA, Ki-67 and hTERT in residual benign meningiomas. ( 16634530 )
2006
25
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. ( 15965488 )
2005
26
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. ( 16029801 )
2005
27
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. ( 15952201 )
2005
28
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. ( 15832773 )
2005
29
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. ( 12706880 )
2003
30
Expression of extracellular matrix markers in benign meningiomas. ( 14719542 )
2003
31
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. ( 12391463 )
2002
32
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. ( 12416559 )
2002
33
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. ( 11928726 )
2002
34
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. ( 12224136 )
2002
35
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. ( 11299001 )
2001
36
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? ( 10701525 )
2000
37
An iatrogenic epidemic of benign meningioma. ( 10670551 )
2000
38
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. ( 11121635 )
2000
39
Radiotherapy in the treatment of benign meningioma of the skull base. ( 10223446 )
1999
40
Images in pathology. Benign meningioma. ( 10458841 )
1999
41
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. ( 9919906 )
1998
42
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. ( 10066099 )
1998
43
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. ( 9352816 )
1997
44
Benign meningioma with a short latency period following irradiation. ( 1440212 )
1992

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.67 CTSL MKI67 PCNA

GO Terms for Benign Meningioma

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 telomere maintenance GO:0000723 8.96 PCNA TERT
2 response to cadmium ion GO:0046686 8.62 PCNA TERT

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 BIRC5 PCNA PGR
2 cytoskeletal protein binding GO:0008092 8.62 EPB41L3 NF2

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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