MCID: BNG002
MIFTS: 34

Benign Meningioma malady

Genetic diseases, Rare diseases, Cancer diseases, Neuronal diseases, Endocrine diseases categories

Aliases & Classifications for Benign Meningioma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 38NCIt
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Benign Meningioma, Aliases & Descriptions:

Name: Benign Meningioma 9 11 43 60
 
Meningioma, Benign 9


Classifications:



External Ids:

Disease Ontology9 DOID:4587
MeSH33 D008579
NCIt38 C4055

Summaries for Benign Meningioma

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MalaCards based summary: Benign Meningioma, also known as meningioma, benign, is related to neurofibromatosis, type 2 and meningioma, familial. An important gene associated with Benign Meningioma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Id Signaling Pathway. The compounds topotecan and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include brain and lung, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Related Diseases for Benign Meningioma

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Diseases in the Benign Meningioma family:

Meningioma, Familial Familial Multiple Meningioma

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis, type 230.3NF2, EPB41L3
2meningioma, familial29.1EPB41L3, TERT, CTSB, CST3, NF2
3brain edema10.3
4hemangiopericytoma10.2
5malignant peripheral nerve sheath tumor10.1TERT, NF2
6laryngeal carcinoma10.1CCNA2, TERT
7laryngeal squamous cell carcinoma10.1TERT, CCNA2
8aneurysm10.0
9grade iii astrocytoma10.0CCNA2, CTSB
10glioblastoma multiforme10.0CCNA2, TERT
11sarcoma10.0TERT, CCNA2, NF2
12amyloidosis10.0CST3, CTSB
13brain cancer9.9TERT, EPB41L3, NF2
14bladder cancer, somatic9.9CCNA2, TERT
15astrocytoma9.8NF2, CTSB, CCNA2
16oral cancer9.8TERT, CCNA2, CTSB
17cervical cancer, somatic9.8CTSB, CCNA2, TERT
18lung cancer9.8CTSB, CCNA2, TERT
19lung benign neoplasm9.8CTSB, EPB41L3, TERT
20glioblastoma9.7CCNA2, TERT, CTSB
21adenoma9.7CTSB, CCNA2, TERT
22malignant glioma9.7CTSB, TERT, NF2
23gastric cancer, somatic9.7TERT, CTSB, CCNA2
24rheumatoid arthritis9.6CTSB, CST3, TERT
25colorectal cancer9.6CTSB, TERT, CCNA2
26alzheimer disease9.6CCNA2, CTSB, CST3
27osteosarcoma, somatic9.6NF2, CTSB, TERT, CCNA2
28breast cancer9.6CCNA2, TERT, NF2, CTSB
29ovarian cancer, somatic9.6TERT, CCNA2, NF2, CTSB
30tongue squamous cell carcinoma9.6CCNA2, CST3, CTSB, TERT
31adenocarcinoma9.4CTSB, TERT, NF2, EPB41L3, CCNA2
32melanoma9.4CTSB, NF2, CST3, CCNA2, TERT
33prostate cancer9.4CST3, TERT, CCNA2, CTSB, NF2

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Symptoms for Benign Meningioma

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Drugs & Therapeutics for Benign Meningioma

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Drug clinical trials:

Search ClinicalTrials for Benign Meningioma

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

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Anatomical Context for Benign Meningioma

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MalaCards organs/tissues related to Benign Meningioma:

31
Brain, Lung

Animal Models for Benign Meningioma or affiliated genes

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MGI Mouse Phenotypes related to Benign Meningioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.8TERT, EPB41L3, NF2, CTSB
2MP:00107687.6CTSB, NF2, CCNA2, EPB41L3, TERT
3MP:00020067.6CTSB, NF2, CST3, EPB41L3, TERT
4MP:00036317.5TERT, EPB41L3, CST3, NF2, CTSB

Publications for Benign Meningioma

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Articles related to Benign Meningioma:

(show all 39)
idTitleAuthorsYear
1
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. (24813096)
2014
2
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. (24751409)
2014
3
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
4
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
5
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
6
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
7
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
8
Is a benign meningioma always an indolent tumor? (21486754)
2011
9
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
10
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. (20819539)
2010
11
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
12
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. (21509301)
2009
13
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
14
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
15
Gamma Knife surgery for benign meningioma. (17695387)
2007
16
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)
2007
17
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. (15980114)
2006
18
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
19
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
20
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
21
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
22
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
23
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
24
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
25
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
26
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. (12391463)
2002
27
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
28
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
29
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. (12224136)
2002
30
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
31
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. (11121635)
2000
32
An iatrogenic epidemic of benign meningioma. (10670551)
2000
33
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
34
Images in pathology. Benign meningioma. (10458841)
1999
35
Radiotherapy in the treatment of benign meningioma of the skull base. (10223446)
1999
36
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
37
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
38
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. (9352816)
1997
39
Benign meningioma with a short latency period following irradiation. (1440212)
1992

Variations for Benign Meningioma

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Expression for genes affiliated with Benign Meningioma

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Search GEO for disease gene expression data for Benign Meningioma.

Pathways for genes affiliated with Benign Meningioma

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Compounds for genes affiliated with Benign Meningioma

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Compounds related to Benign Meningioma according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
1topotecan43 1210.8CST3, CCNA2
2depsipeptide439.7TERT, CCNA2
3homocysteine43 2410.6CCNA2, CST3
4adpribose439.6TERT, CCNA2
5eb 108943 5910.6CTSB, CCNA2
6actinidin439.5CST3, CTSB
7thymidylate439.5CCNA2, TERT
8vitamin b6439.5CTSB, CST3
9leupeptin439.5CTSB, CST3
10pyridoxal 5-phosphate439.4CTSB, CST3
11tripeptide439.4CTSB, CST3
12kininogen439.4CTSB, CST3
13rapamycin439.4TERT, CCNA2, NF2
14aprotinin43 1210.4CTSB, CST3
15progesterone43 28 59 24 1213.3EPB41L3, CCNA2, NF2
16urea43 24 1211.1CTSB, CST3
17gold439.1CTSB, CST3, CCNA2
18cyclosporin a43 28 5911.0CTSB, CST3, CCNA2
19hydrogen43 2410.0CCNA2, CST3, CTSB
20camptothecin43 59 1211.0CTSB, CCNA2, TERT
215fluorouracil439.0TERT, CCNA2, CTSB
22aspartate439.0CCNA2, CST3, CTSB
23etoposide43 49 59 1212.0CTSB, CCNA2, TERT
24paclitaxel43 49 1211.0CTSB, CCNA2, TERT
25ly294002438.9CTSB, CCNA2, TERT
26doxorubicin43 49 1210.9TERT, CCNA2, CTSB
27dexamethasone43 49 28 1211.9CTSB, CST3, CCNA2
28h2o2438.8CTSB, CCNA2, TERT
29zinc43 249.6TERT, CCNA2, CTSB
30paraffin438.6TERT, CCNA2, NF2, CTSB
31nitric oxide43 24 1210.6CTSB, CCNA2, TERT
32cysteine438.5TERT, CST3, NF2, CTSB
33thymidine43 249.5CTSB, CCNA2, EPB41L3, TERT
34cisplatin43 49 59 1211.5TERT, CCNA2, CST3, CTSB
35vegf438.5TERT, CCNA2, CST3, CTSB
36arginine438.5CTSB, CST3, CCNA2, TERT
37tyrosine438.4CTSB, NF2, CCNA2, TERT
38alanine438.4CTSB, CST3, CCNA2
39threonine438.1CTSB, NF2, CST3, CCNA2, TERT
40serine438.1CTSB, NF2, CST3, CCNA2, TERT
41calcium43 49 24 1211.0TERT, CCNA2, CST3, CTSB

GO Terms for genes affiliated with Benign Meningioma

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Cellular components related to Benign Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:00198989.5NF2, EPB41L3

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.1CTSB, NF2, CST3, CCNA2, EPB41L3, TERT

Products for genes affiliated with Benign Meningioma

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Sources for Benign Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet