MCID: BNG002
MIFTS: 39

Benign Meningioma malady

Genetic diseases, Cancer diseases, Rare diseases, Neuronal diseases, Endocrine diseases categories
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Summaries for Benign Meningioma

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33MalaCards
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MalaCards: Benign Meningioma, also known as meningioma, benign, is related to meningioma and neurofibromatosis. An important gene associated with Benign Meningioma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Id Signaling Pathway. The compounds topotecan and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include brain and lung, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Benign Meningioma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH
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Classifications:



Aliases & Descriptions:

benign meningioma 8 10 45 62
meningioma, benign 8


External Ids:

Disease Ontology8 DOID:4587
NCIt40 C4055
MeSH35 D008579

Related Diseases for Benign Meningioma

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17GeneCards, 18GeneDecks
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Diseases in the Meningioma family:

benign meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma31.0TERT, EPB41L3, CST3, NF2, CTSB
2neurofibromatosis30.1EPB41L3, NF2
3brain edema10.2
4hemangiopericytoma10.2
5malignant peripheral nerve sheath tumor10.0TERT, NF2
6laryngeal benign neoplasm10.0CCNA2, TERT
7laryngeal squamous cell carcinoma10.0CCNA2, TERT
8anaplastic astrocytoma10.0CCNA2, CTSB
9amyloid tumor10.0CTSB, CST3
10glioblastoma multiforme10.0CCNA2, TERT
11sarcoma10.0TERT, CCNA2, NF2
12amyloidosis10.0CST3, CTSB
13brain cancer10.0NF2, EPB41L3, TERT
14non-small cell lung carcinoma10.0CCNA2, EPB41L3, TERT
15bladder carcinoma10.0CCNA2, TERT
16astrocytoma10.0CCNA2, NF2, CTSB
17oral cancer10.0TERT, CCNA2, CTSB
18cervical cancer10.0CTSB, CCNA2, TERT
19lung cancer9.9TERT, CCNA2, CTSB
20lung benign neoplasm9.9TERT, EPB41L3, CTSB
21adenoma9.9CTSB, CCNA2, TERT
22malignant glioma9.9TERT, NF2, CTSB
23stomach cancer9.9CTSB, CCNA2, TERT
24alzheimer's disease9.9CCNA2, CST3, CTSB
25colon cancer9.9CTSB, CCNA2, TERT
26rheumatoid arthritis9.9CTSB, CST3, TERT
27osteosarcoma9.9CTSB, NF2, CCNA2, TERT
28breast cancer9.9TERT, CCNA2, NF2, CTSB
29ovarian cancer9.9TERT, CCNA2, NF2, CTSB
30colorectal cancer9.9TERT, CST3, NF2, CTSB
31tongue squamous cell carcinoma9.9TERT, CCNA2, CST3, CTSB
32adenocarcinoma9.9TERT, EPB41L3, CCNA2, NF2, CTSB
33melanoma9.9TERT, CCNA2, CST3, NF2, CTSB
34prostate cancer9.9TERT, CCNA2, CST3, NF2, CTSB

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Symptoms for Benign Meningioma

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Drugs & Therapeutics for Benign Meningioma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Benign Meningioma

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

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Anatomical Context for Benign Meningioma

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33MalaCards
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MalaCards organs/tissues related to Benign Meningioma:

33
Brain, Lung

Animal Models for Benign Meningioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Benign Meningioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.8TERT, EPB41L3, NF2, CTSB
2MP:00107687.6CTSB, NF2, CCNA2, EPB41L3, TERT
3MP:00020067.6CTSB, NF2, CST3, EPB41L3, TERT
4MP:00036317.5TERT, EPB41L3, CST3, NF2, CTSB

Publications for Benign Meningioma

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52PubMed
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Articles related to Benign Meningioma:

(show all 35)
idTitleAuthorsYear
1
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
2
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
3
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
4
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
5
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
6
Is a benign meningioma always an indolent tumor? (21486754)
2011
7
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
8
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. (20819539)
2010
9
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
10
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. (21509301)
2009
11
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
12
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
13
Gamma Knife surgery for benign meningioma. (17695387)
2007
14
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)
2007
15
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. (15980114)
2006
16
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
17
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
18
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
19
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
20
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
21
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
22
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
23
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
24
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. (12391463)
2002
25
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
26
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
27
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. (12224136)
2002
28
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
29
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
30
Images in pathology. Benign meningioma. (10458841)
1999
31
Radiotherapy in the treatment of benign meningioma of the skull base. (10223446)
1999
32
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
33
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
34
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. (9352816)
1997
35
Benign meningioma with a short latency period following irradiation. (1440212)
1992

Variations for Benign Meningioma

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Expression for genes affiliated with Benign Meningioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for genes affiliated with Benign Meningioma

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50PathCards, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 54R&D Systems
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Compounds for genes affiliated with Benign Meningioma

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45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB
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Compounds related to Benign Meningioma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1topotecan45 1110.8CST3, CCNA2
2depsipeptide459.7TERT, CCNA2
3homocysteine45 2410.6CCNA2, CST3
4adpribose459.6TERT, CCNA2
5eb 108945 6110.6CTSB, CCNA2
6actinidin459.5CST3, CTSB
7thymidylate459.5CCNA2, TERT
8vitamin b6459.5CTSB, CST3
9leupeptin459.5CTSB, CST3
10pyridoxal 5-phosphate459.4CTSB, CST3
11tripeptide459.4CTSB, CST3
12kininogen459.4CTSB, CST3
13rapamycin459.4TERT, CCNA2, NF2
14aprotinin45 1110.4CTSB, CST3
15progesterone45 29 61 24 1113.3EPB41L3, CCNA2, NF2
16urea45 24 1111.1CTSB, CST3
17gold459.1CTSB, CST3, CCNA2
18cyclosporin a45 29 6111.0CTSB, CST3, CCNA2
19hydrogen45 2410.0CCNA2, CST3, CTSB
20camptothecin45 61 1111.0CTSB, CCNA2, TERT
215fluorouracil459.0TERT, CCNA2, CTSB
22aspartate459.0CCNA2, CST3, CTSB
23etoposide45 51 61 1112.0CTSB, CCNA2, TERT
24paclitaxel45 51 1111.0CTSB, CCNA2, TERT
25ly294002458.9CTSB, CCNA2, TERT
26doxorubicin45 51 1110.9TERT, CCNA2, CTSB
27dexamethasone45 51 29 1111.9CTSB, CST3, CCNA2
28h2o2458.8CTSB, CCNA2, TERT
29zinc45 249.6TERT, CCNA2, CTSB
30paraffin458.6TERT, CCNA2, NF2, CTSB
31nitric oxide45 24 1110.6CTSB, CCNA2, TERT
32cysteine458.5TERT, CST3, NF2, CTSB
33thymidine45 249.5CTSB, CCNA2, EPB41L3, TERT
34cisplatin45 51 61 1111.5TERT, CCNA2, CST3, CTSB
35vegf458.5TERT, CCNA2, CST3, CTSB
36arginine458.5CTSB, CST3, CCNA2, TERT
37tyrosine458.4CTSB, NF2, CCNA2, TERT
38alanine458.4CTSB, CST3, CCNA2
39threonine458.1CTSB, NF2, CST3, CCNA2, TERT
40serine458.1CTSB, NF2, CST3, CCNA2, TERT
41calcium45 51 24 1111.0TERT, CCNA2, CST3, CTSB

GO Terms for genes affiliated with Benign Meningioma

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16Gene Ontology
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Cellular components related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:0198989.5NF2, EPB41L3

Molecular functions related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1CTSB, NF2, CST3, CCNA2, EPB41L3, TERT

Products for genes affiliated with Benign Meningioma

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  • Antibodies
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Sources for Benign Meningioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet