MCID: BNG002
MIFTS: 34

Benign Meningioma

Categories: Neuronal diseases, Rare diseases, Cancer diseases, Genetic diseases

Aliases & Classifications for Benign Meningioma

MalaCards integrated aliases for Benign Meningioma:

Name: Benign Meningioma 12 51 14 69
Meningioma, Benign 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4587
MeSH 41 D008579
NCIt 46 C4055
UMLS 69 C0281784

Summaries for Benign Meningioma

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to meningioma, familial and lung meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Hydroxyurea and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain and lung, and related phenotypes are Increased cell death HMECs cells and Increased Nanog expression

Related Diseases for Benign Meningioma

Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 29.9 CTSL EPB41L3 MKI67 NF2 PCNA PGR
2 lung meningioma 10.4 NF2 PGR
3 olfactory groove meningioma 10.4 NF2 PGR
4 benign ependymoma 10.4 EPB41L3 NF2
5 chordoid glioma 10.4 NF2 PGR
6 anterior cranial fossa meningioma 10.3 NF2 PGR
7 intraventricular meningioma 10.3 NF2 TERT
8 spinal canal and spinal cord meningioma 10.3 NF2 PGR
9 spinal meningioma 10.3 NF2 PGR
10 peritoneal mesothelioma 10.3 NF2 PGR
11 benign breast phyllodes tumor 10.3 MKI67 PGR
12 endometrial mucinous adenocarcinoma 10.3 MKI67 PGR
13 adenosarcoma 10.3 MKI67 PGR
14 spinal cord ependymoma 10.3 EPB41L3 NF2
15 clear cell ependymoma 10.2 EPB41L3 NF2
16 spermatocele 10.2 PGR TERT
17 soft tissue sarcoma 10.2 MKI67 TERT
18 malignant peritoneal mesothelioma 10.2 BIRC5 NF2
19 panophthalmitis 10.2 CTSL TERT
20 meninges hemangiopericytoma 10.2 EPB41L3 TERT
21 neurofibromatosis, type ii 10.1 EPB41L3 NF2
22 cervical carcinosarcoma 10.1 BIRC5 PGR
23 ependymoma 10.1 MKI67 NF2
24 purulent endophthalmitis 10.1 CTSL TERT
25 organ system benign neoplasm 10.1 NF2 PGR
26 keratocystic odontogenic tumor 10.0 BIRC5 MKI67
27 lymphangiomatosis 10.0 PCNA PGR
28 bizarre leiomyoma 10.0 PCNA PGR
29 serous cystadenocarcinoma 10.0 BIRC5 PGR
30 squamous cell carcinoma of the larynx 10.0 MKI67 PCNA
31 bladder adenocarcinoma 10.0 MKI67 PCNA
32 bowen's disease 10.0 MKI67 PCNA
33 acoustic neuroma 9.9 NF2 PCNA
34 oral leukoplakia 9.9 MKI67 PCNA
35 prostatic hypertrophy 9.9 PCNA PGR
36 inverted papilloma 9.9 MKI67 PCNA
37 leukoplakia 9.9 MKI67 PCNA
38 juvenile nasopharyngeal angiofibroma 9.9 PCNA PGR
39 hydrops, lactic acidosis, and sideroblastic anemia 9.9
40 brain edema 9.9
41 cervical intraepithelial neoplasia 9.8 BIRC5 MKI67 TERT
42 wilms tumor 1 9.8 BIRC5 PGR TERT
43 hemangiopericytoma, malignant 9.8
44 aging 9.8
45 endometrial adenocarcinoma 9.8 MKI67 PGR
46 salivary gland adenoid cystic carcinoma 9.8 MKI67 PCNA
47 cerebral amyloid angiopathy, cst3-related 9.6
48 cerebritis 9.6
49 ameloblastoma 9.6 PCNA TERT

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to Benign Meningioma

Symptoms & Phenotypes for Benign Meningioma

GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.26 BIRC5 CTSL PCNA PGR
2 Increased Nanog expression GR00371-A-1 9.02 BIRC5 MKI67 PCNA
3 Increased Nanog expression GR00371-A-3 9.02 BIRC5
4 Increased Nanog expression GR00371-A-5 9.02 BIRC5

MGI Mouse Phenotypes related to Benign Meningioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 BIRC5 EPB41L3 NF2 PCNA PGR TERT
2 normal MP:0002873 9.1 BIRC5 EPB41L3 HSD17B13 MKI67 PGR TERT

Drugs & Therapeutics for Benign Meningioma

Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2 127-07-1 3657
2 Nucleic Acid Synthesis Inhibitors Phase 2
3 Anti-Infective Agents Phase 2
4 Antiviral Agents Phase 2
5 Interferon-alpha Phase 2
6 interferons Phase 2
7 Iron-Dextran Complex Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proton/Photon Rt - Benign Meningiomas(P92-13) Completed NCT02947984 Phase 3
2 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
3 S9811 Hydroxyurea in Treating Patients With Unresectable Benign Meningioma Completed NCT00003590 Phase 2 hydroxyurea
4 Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant Meningiomas Completed NCT00002965 Phase 2
5 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

MalaCards organs/tissues related to Benign Meningioma:

38
Brain, Lung

Publications for Benign Meningioma

Articles related to Benign Meningioma:

(show all 45)
# Title Authors Year
1
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. ( 27815026 )
2017
2
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. ( 27284345 )
2016
3
Review of controversies in management of non-benign meningioma. ( 27338209 )
2016
4
The role and regulatory mechanism of IL-1I^ on the methylation of the NF2 gene in benign meningiomas and leptomeninges. ( 26840621 )
2016
5
Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma. ( 26385916 )
2015
6
A case of benign meningioma presented with subdural hemorrhage. ( 25977904 )
2015
7
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. ( 24813096 )
2014
8
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. ( 24751409 )
2014
9
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. ( 23840654 )
2013
10
Impaired survival and long-term neurological problems in benign meningioma. ( 22406926 )
2012
11
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. ( 22285662 )
2012
12
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. ( 23285163 )
2012
13
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. ( 22420586 )
2012
14
Is a benign meningioma always an indolent tumor? ( 21486754 )
2011
15
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. ( 20819539 )
2010
16
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. ( 20428925 )
2010
17
Benign meningioma developing late lung metastases: case report and review of the literature. ( 19919820 )
2009
18
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. ( 21509301 )
2009
19
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. ( 19122989 )
2008
20
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. ( 18586307 )
2008
21
Gamma Knife surgery for benign meningioma. ( 17695387 )
2007
22
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? ( 17961045 )
2007
23
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. ( 16465773 )
2006
24
PCNA, Ki-67 and hTERT in residual benign meningiomas. ( 16634530 )
2006
25
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. ( 15980114 )
2006
26
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. ( 16029801 )
2005
27
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. ( 15965488 )
2005
28
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. ( 15952201 )
2005
29
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. ( 15832773 )
2005
30
Expression of extracellular matrix markers in benign meningiomas. ( 14719542 )
2003
31
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. ( 12706880 )
2003
32
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. ( 12224136 )
2002
33
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. ( 12416559 )
2002
34
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. ( 11928726 )
2002
35
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. ( 12391463 )
2002
36
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. ( 11299001 )
2001
37
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. ( 11121635 )
2000
38
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? ( 10701525 )
2000
39
An iatrogenic epidemic of benign meningioma. ( 10670551 )
2000
40
Radiotherapy in the treatment of benign meningioma of the skull base. ( 10223446 )
1999
41
Images in pathology. Benign meningioma. ( 10458841 )
1999
42
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. ( 9919906 )
1998
43
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. ( 10066099 )
1998
44
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. ( 9352816 )
1997
45
Benign meningioma with a short latency period following irradiation. ( 1440212 )
1992

Variations for Benign Meningioma

Expression for Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for Benign Meningioma

Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 CTSL MKI67 PCNA

GO Terms for Benign Meningioma

Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 telomere maintenance GO:0000723 8.96 PCNA TERT
2 response to cadmium ion GO:0046686 8.62 PCNA TERT

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 BIRC5 PCNA PGR
2 cytoskeletal protein binding GO:0008092 8.62 EPB41L3 NF2

Sources for Benign Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....