MCID: BNG002
MIFTS: 45

Benign Meningioma malady

Summaries for Benign Meningioma

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MalaCards: Benign Meningioma, also known as meningioma, benign, is related to meningioma and hemangiopericytoma. An important gene associated with Benign Meningioma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Cell Cycle and Lagging Strand Synthesis. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and pituitary, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Benign Meningioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

benign meningioma 8 10 44 60
meningioma, benign 8


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Disease Ontology8 DOID:4587
MeSH34 D008579
NCIt39 C4055

Related Diseases for Benign Meningioma

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17GeneCards, 18GeneDecks
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Diseases in the Meningioma family:

benign meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma31.1PGR, PCNA, MKI67
2hemangiopericytoma30.2MDM2
3brain meningioma10.3
4brain edema10.2
5ductal carcinoma in situ10.0PGR
6malignant mesothelioma10.0NF2
7tongue cancer10.0TERT
8pancreatitis10.0CTSB
9gingivitis10.0CST3
10cholangiocarcinoma10.0TERT
11uterine sarcoma10.0MDM2
12fibromatosis10.0PGR
13wilms tumor10.0PTN
14hepatitis c10.0CTSB
15papilloma10.0PCNA
16spinal meningioma10.0NF2
17hepatoblastoma10.0BIRC5
18testicular cancer10.0CCNA2
19myoma10.0PGR
20neurofibromatosis10.0NF2
21leiomyosarcoma10.0PGR, MDM2
22teratocarcinoma10.0PLAU
23hepatitis b10.0TERT, CTSB
24actinic keratosis10.0PCNA
25endometriosis10.0PLAU, PGR
26myelodysplastic syndromes10.0BIRC5
27psoriasis10.0CTSL
28cervical adenocarcinoma10.0PGR
29keratoacanthoma10.0PCNA, MKI67
30galactosemia10.0PCNA
31chondrosarcoma10.0PLAU, MDM2
32leukoplakia10.0PCNA, MKI67
33arthritis10.0CTSB, CTSL
34ependymoma10.0MDM2, NF2, MKI67
35myeloma10.0CCNA2, CST3, BIRC5
36cervical intraepithelial neoplasia10.0TERT, BIRC5, MKI67
37phyllode tumor10.0PGR, MKI67, CCNA2
38hemangioma10.0SLC2A1, ETS1
39myeloid leukemia10.0CCNA2, BIRC5
40gastrointestinal stromal tumor10.0NF2, MKI67, PCNA
41fibrous meningioma10.0NF2, EGFL6
42malignant peripheral nerve sheath tumor10.0TERT, NF2, MDM2
43ataxia telangiectasia10.0MDM2, ETS1
44gastritis10.0PCNA
45anaplastic ependymoma10.0MDM2, NF2
46adenosarcoma10.0PGR
47ischemia10.0ETS1, NF2, CST3
48malignant fibroxanthoma10.0CCNA2, MDM2, MKI67
49dementia10.0CST3
50leiomyoma10.0PGR, PCNA, MKI67

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Clinical Features for Benign Meningioma

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Drugs & Therapeutics for Benign Meningioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Benign Meningioma

Drug clinical trials:

Search ClinicalTrials for Benign Meningioma

Search NIH Clinical Center for Benign Meningioma

Search CenterWatch for Benign Meningioma

Genetic Tests for Benign Meningioma

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Anatomical Context for Benign Meningioma

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32MalaCards
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MalaCards organs/tissues related to Benign Meningioma:

32
Brain, Lung, Pituitary

Animal Models for Benign Meningioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Benign Meningioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8CTSL, NF2, EPB41L3, TERT
2MP:00053899.5CTSL, NF2, PCNA, PLAU, TERT, PTN
3MP:00020069.5CST3, CTSB, MDM2, NF2, EPB41L3, PGR
4MP:00053809.5MDM2, NF2, ETS1, PGR, BIRC5, SLC2A1
5MP:00036319.4CSTB, CST3, CTSL, NF2, EPB41L3, SLC2A1
6MP:00053769.3CST3, CTSL, CTSB, NF2, ETS1, PGR
7MP:00053978.8CCNA2, CTSL, MDM2, ETS1, PCNA, MCM7
8MP:00053788.7CSTB, CTSL, CTSB, MDM2, NF2, ETS1
9MP:00053868.7CSTB, CTSL, CTSB, MDM2, NF2, EPB41L3
10MP:00053878.6CCNA2, CSTB, CTSL, CTSB, MDM2, NF2
11MP:00107688.4ETS1, NF2, MDM2, CTSB, CTSL, CCNA2
12MP:00053848.2PTN, CCNA2, CSTB, CTSL, CTSB, MDM2

Publications for Benign Meningioma

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50PubMed
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Articles related to Benign Meningioma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
2
Benign spinal meningioma without dural attachment presenting delayed CSF dissemination and malignant transformation. (22915133)
2013
3
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
4
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
5
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
6
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
7
Meningial perineurioma: a benign peripheral nerve sheath tumor in a previously unrecognized central nervous system location, mimicking meningioma. (21831532)
2011
8
Stereotactic radiosurgery and radiotherapy in benign intracranial meningioma. (22776812)
2011
9
Usefulness of quantitative proton MR spectroscopy in the differentiation of benign and malignant meningioma. (22295694)
2011
10
Is a benign meningioma always an indolent tumor? (21486754)
2011
11
Seeding metastases of a benign intraventricular meningioma along the surgical track. (20036547)
2010
12
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
13
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. (20819539)
2010
14
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
15
Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas. (18418552)
2008
16
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
17
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
18
MIB-1 immunolabeling: a valuable marker in prediction of benign recurring meningiomas. (18018472)
2007
19
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)
2007
20
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. (15980114)
2006
21
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
22
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
23
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
24
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
25
Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression. (15540215)
2005
26
Chromosomal and genetic abnormalities in benign and malignant meningiomas using DNA microarray. (16197812)
2005
27
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
28
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
29
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
30
Hormone receptors in benign intracranial meningiomas. (17415829)
2004
31
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
32
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
33
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
34
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
35
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
36
Meningioma: a cytogenetic model of a complex benign human tumor, including data on 394 karyotyped cases. (11528114)
2001
37
Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas. (11567227)
2001
38
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. (11121635)
2000
39
An iatrogenic epidemic of benign meningioma. (10670551)
2000
40
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
41
p53 and PCNA expression in benign, atypical and malignant meningiomas. (10647228)
1999
42
Images in pathology. Benign meningioma. (10458841)
1999
43
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
44
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
45
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. (9352816)
1997
46
Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. (8607065)
1996
47
Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas. (8867694)
1995
48
Benign brain tumors. Meningiomas, pituitary tumors, and acoustic neuromas. (8584005)
1995
49
Benign meningioma with a short latency period following irradiation. (1440212)
1992
50
Osseous metastases from a benign intraventricular meningioma. Case report. (1414521)
1992

Genetic Variations for Benign Meningioma

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Expression for genes affiliated with Benign Meningioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for genes affiliated with Benign Meningioma

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Benign Meningioma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Benign Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CTSL
2resveratrol44 59 11 2413.5PGR
3diazomethane4410.2SLC2A1, CTSB, CTSL
4etoposide44 49 59 1113.1CCNA2, TERT, CTSB, MDM2
5paclitaxel44 49 1112.1CCNA2, TERT, BIRC5, MDM2, CTSB, PGR
6h2o24410.0PTN, CCNA2, ETS1, PCNA, CTSB
7arsenite44 2411.0PGR, PCNA, MDM2, TERT, BIRC5, CCNA2
8adpribose4410.0BIRC5, MDM2, CCNA2, PCNA, TERT
9kininogen4410.0CSTB, CTSL, CTSB, PLAU, CST3
10camptothecin44 59 1111.9CTSB, PCNA, BIRC5, MDM2, TERT, CCNA2
11thymidylate449.9TERT, BIRC5, PCNA, MKI67, CCNA2, MDM2
12adriamycin449.9PLAU, PGR, MDM2, TERT, BIRC5
13actinidin449.9CTSB, CTSL, CST3
14agar449.8PTN, MDM2, NF2, PGR, BIRC5, SLC2A1
15thapsigargin44 5910.8PLAU, SLC2A1, PCNA, MDM2, CTSB, CCNA2
16dexamethasone44 49 28 1112.8SLC2A1, CCNA2, BIRC5, PCNA, MDM2, CTSL
17leupeptin449.8PLAU, CST3, CTSL, CTSB
18methotrexate44 49 1111.8BIRC5, PGR, CCNA2, MDM2, MKI67, PCNA
19pd 98,059449.8SLC2A1, PLAU, BIRC5, ETS1, TERT, MDM2
20docetaxel44 49 59 1112.8PGR, BIRC5, MDM2, CCNA2, PLAU
21doxorubicin44 49 1111.7CTSB, MDM2, MKI67, CCNA2, TERT, PLAU
22tamoxifen44 49 28 1112.7PGR, HSD17B13, PLAU, BIRC5, PCNA, MKI67
23matrigel449.7CST3, CTSL, CTSB, PTN, ETS1, PLAU
24ly294002449.7PTN, PLAU, SLC2A1, MDM2, CTSB, TERT
25genistein44 28 59 2 11 2414.6MDM2, PCNA, PGR, BIRC5, SLC2A1, PLAU
26cyclosporin a44 28 5911.6CTSB, CCNA2, CTSL, ETS1, PCNA, PGR
27wortmannin449.6TERT, SLC2A1, PLAU, PTN, BIRC5, MDM2
28serine449.6MKI67, NF2, CTSB, CTSL, CSTB, CCNA2
29glucose449.6BIRC5, SLC2A1, CTSB, CST3, HSD17B13, ETS1
30steroid449.5BIRC5, PLAU, HSD17B13, MKI67, CCNA2, MDM2
31aspartate449.5PGR, PLAU, PCNA, MDM2, CCNA2, CTSB
32threonine449.5NF2, TERT, BIRC5, ETS1, MKI67, MDM2
33lactate449.5SLC2A1, CST3, HSD17B13, CTSB, MKI67, BIRC5
345fluorouracil449.5PCNA, TERT, SLC2A1, BIRC5, PGR, CTSB
35testosterone44 59 11 2412.5MDM2, TERT, BIRC5, PGR, PCNA, MKI67
36dutp449.5MDM2, MKI67, PCNA, BIRC5
37estradiol44 11 2411.5HSD17B13, CCNA2, PLAU, BIRC5, PGR, PCNA
38arginine449.4ETS1, PCNA, PLAU, TERT, MDM2, CTSB
39phosphatidylinositol449.4SLC2A1, PTN, ETS1, PLAU, BIRC5, CCNA2
40oligonucleotide449.3CCNA2, TERT, BIRC5, PTN, PCNA, ETS1
41nitric oxide44 11 2411.3ETS1, BIRC5, TERT, MKI67, PTN, CCNA2
42paraffin449.3MDM2, PCNA, PGR, BIRC5, PLAU, TERT
43alanine449.1BIRC5, PLAU, CTSL, PGR, PCNA, ETS1
44cisplatin44 49 59 1112.1CCNA2, CST3, TERT, SLC2A1, PLAU, BIRC5
45thymidine44 2410.1ETS1, PLAU, BIRC5, EPB41L3, PCNA, PTN
46retinoic acid44 2410.1CTSB, CCNA2, CTSL, MKI67, ETS1, PCNA
47cysteine449.0CST3, MDM2, CTSB, CTSL, CSTB, TERT
48progesterone44 59 28 11 2412.9MDM2, PCNA, NF2, BIRC5, PGR, EPB41L3
49tyrosine448.7CTSB, PTN, TERT, SLC2A1, PLAU, BIRC5
50vegf448.7PTN, CTSL, CTSB, MDM2, PLAU, MKI67

GO Terms for genes affiliated with Benign Meningioma

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16Gene Ontology
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Cellular components related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.0CTSL, CTSB
2female pronucleusGO:0019399.9SLC2A1, CCNA2
3nucleoplasmGO:0056549.5TERT, PGR, MCM7, PCNA, MDM2, CCNA2
4nucleolusGO:0057309.2TERT, PGR, PCNA, MKI67, NF2, MDM2

Biological processes related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to thyroid hormone stimulusGO:09706710.1CTSB, CTSL
2negative regulation of peptidase activityGO:0104669.9CST3, CSTB

Molecular functions related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase inhibitor activityGO:00486910.0BIRC5, CST3, CSTB
2protein bindingGO:0055157.5TERT, CCNA2, CST3, CTSL, CTSB, MDM2

Products for genes affiliated with Benign Meningioma

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Sources for Benign Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet