MCID: BNG002
MIFTS: 40

Benign Meningioma malady

Genetic diseases, Cancer diseases, Rare diseases, Neuronal diseases, Endocrine diseases categories
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Summaries for Benign Meningioma

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MalaCards based summary: Benign Meningioma, also known as meningioma, benign, is related to neurofibromatosis and meningioma. An important gene associated with Benign Meningioma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Id Signaling Pathway. The compounds topotecan and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include brain and lung, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Benign Meningioma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 39NCIt
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Benign Meningioma, Aliases & Descriptions:

Name: Benign Meningioma 8 10 44 62
 
Meningioma, Benign 8


Classifications:



External Ids:

Disease Ontology8 DOID:4587
MeSH34 D008579
NCIt39 C4055

Related Diseases for Benign Meningioma

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Diseases in the Meningioma family:

benign meningioma Familial Meningioma
Meningioma, Sis-Related

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.3EPB41L3, NF2
2meningioma30.3TERT, EPB41L3, CST3, NF2, CTSB
3brain edema10.3
4hemangiopericytoma10.2
5malignant peripheral nerve sheath tumor10.2TERT, NF2
6laryngeal benign neoplasm10.1CCNA2, TERT
7laryngeal squamous cell carcinoma10.1CCNA2, TERT
8aneurysm10.0
9grade iii astrocytoma10.0CCNA2, CTSB
10amyloid tumor10.0CTSB, CST3
11glioblastoma multiforme10.0CCNA2, TERT
12sarcoma10.0TERT, CCNA2, NF2
13amyloidosis10.0CST3, CTSB
14brain cancer9.9NF2, EPB41L3, TERT
15non-small cell lung carcinoma9.9CCNA2, EPB41L3, TERT
16bladder carcinoma9.9CCNA2, TERT
17astrocytoma9.9CCNA2, NF2, CTSB
18oral cancer9.8TERT, CCNA2, CTSB
19cervical cancer9.8CTSB, CCNA2, TERT
20lung cancer9.8TERT, CCNA2, CTSB
21lung benign neoplasm9.8TERT, EPB41L3, CTSB
22glioblastoma9.8TERT, CCNA2, CTSB
23adenoma9.7CTSB, CCNA2, TERT
24malignant glioma9.7TERT, NF2, CTSB
25stomach cancer9.7CTSB, CCNA2, TERT
26alzheimer's disease9.6CCNA2, CST3, CTSB
27rheumatoid arthritis9.6CTSB, CST3, TERT
28colonic benign neoplasm9.6CTSB, CCNA2, TERT
29osteosarcoma9.6CTSB, NF2, CCNA2, TERT
30breast cancer9.6TERT, CCNA2, NF2, CTSB
31ovarian cancer9.6TERT, CCNA2, NF2, CTSB
32colorectal cancer9.6TERT, CST3, NF2, CTSB
33tongue squamous cell carcinoma9.6TERT, CCNA2, CST3, CTSB
34adenocarcinoma9.4TERT, EPB41L3, CCNA2, NF2, CTSB
35melanoma9.4TERT, CCNA2, CST3, NF2, CTSB
36prostate cancer9.4TERT, CCNA2, CST3, NF2, CTSB

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Symptoms for Benign Meningioma

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Drugs & Therapeutics for Benign Meningioma

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Drug clinical trials:

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Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

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Anatomical Context for Benign Meningioma

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MalaCards organs/tissues related to Benign Meningioma:

32
Brain, Lung

Animal Models for Benign Meningioma or affiliated genes

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MGI Mouse Phenotypes related to Benign Meningioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.8TERT, EPB41L3, NF2, CTSB
2MP:00107687.6CTSB, NF2, CCNA2, EPB41L3, TERT
3MP:00020067.6CTSB, NF2, CST3, EPB41L3, TERT
4MP:00036317.5TERT, EPB41L3, CST3, NF2, CTSB

Publications for Benign Meningioma

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Articles related to Benign Meningioma:

(show all 39)
idTitleAuthorsYear
1
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. (24813096)
2014
2
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. (24751409)
2014
3
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
4
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
5
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
6
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
7
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
8
Is a benign meningioma always an indolent tumor? (21486754)
2011
9
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
10
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. (20819539)
2010
11
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
12
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. (21509301)
2009
13
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
14
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
15
Gamma Knife surgery for benign meningioma. (17695387)
2007
16
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)
2007
17
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. (15980114)
2006
18
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
19
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
20
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
21
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
22
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
23
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
24
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
25
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
26
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. (12391463)
2002
27
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
28
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
29
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. (12224136)
2002
30
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
31
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. (11121635)
2000
32
An iatrogenic epidemic of benign meningioma. (10670551)
2000
33
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
34
Images in pathology. Benign meningioma. (10458841)
1999
35
Radiotherapy in the treatment of benign meningioma of the skull base. (10223446)
1999
36
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
37
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
38
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. (9352816)
1997
39
Benign meningioma with a short latency period following irradiation. (1440212)
1992

Variations for Benign Meningioma

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Expression for genes affiliated with Benign Meningioma

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Expression patterns in normal tissues for genes affiliated with Benign Meningioma

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Pathways for genes affiliated with Benign Meningioma

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Compounds for genes affiliated with Benign Meningioma

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Compounds related to Benign Meningioma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1topotecan44 1110.8CST3, CCNA2
2depsipeptide449.7TERT, CCNA2
3homocysteine44 2410.6CCNA2, CST3
4adpribose449.6TERT, CCNA2
5eb 108944 6110.6CTSB, CCNA2
6actinidin449.5CST3, CTSB
7thymidylate449.5CCNA2, TERT
8vitamin b6449.5CTSB, CST3
9leupeptin449.5CTSB, CST3
10pyridoxal 5-phosphate449.4CTSB, CST3
11tripeptide449.4CTSB, CST3
12kininogen449.4CTSB, CST3
13rapamycin449.4TERT, CCNA2, NF2
14aprotinin44 1110.4CTSB, CST3
15progesterone44 28 61 24 1113.3EPB41L3, CCNA2, NF2
16urea44 24 1111.1CTSB, CST3
17gold449.1CTSB, CST3, CCNA2
18cyclosporin a44 28 6111.0CTSB, CST3, CCNA2
19hydrogen44 2410.0CCNA2, CST3, CTSB
20camptothecin44 61 1111.0CTSB, CCNA2, TERT
215fluorouracil449.0TERT, CCNA2, CTSB
22aspartate449.0CCNA2, CST3, CTSB
23etoposide44 50 61 1112.0CTSB, CCNA2, TERT
24paclitaxel44 50 1111.0CTSB, CCNA2, TERT
25ly294002448.9CTSB, CCNA2, TERT
26doxorubicin44 50 1110.9TERT, CCNA2, CTSB
27dexamethasone44 50 28 1111.9CTSB, CST3, CCNA2
28h2o2448.8CTSB, CCNA2, TERT
29zinc44 249.6TERT, CCNA2, CTSB
30paraffin448.6TERT, CCNA2, NF2, CTSB
31nitric oxide44 24 1110.6CTSB, CCNA2, TERT
32cysteine448.5TERT, CST3, NF2, CTSB
33thymidine44 249.5CTSB, CCNA2, EPB41L3, TERT
34cisplatin44 50 61 1111.5TERT, CCNA2, CST3, CTSB
35vegf448.5TERT, CCNA2, CST3, CTSB
36arginine448.5CTSB, CST3, CCNA2, TERT
37tyrosine448.4CTSB, NF2, CCNA2, TERT
38alanine448.4CTSB, CST3, CCNA2
39threonine448.1CTSB, NF2, CST3, CCNA2, TERT
40serine448.1CTSB, NF2, CST3, CCNA2, TERT
41calcium44 50 24 1111.0TERT, CCNA2, CST3, CTSB

GO Terms for genes affiliated with Benign Meningioma

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Cellular components related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of membraneGO:0198989.5NF2, EPB41L3

Molecular functions related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1CTSB, NF2, CST3, CCNA2, EPB41L3, TERT

Products for genes affiliated with Benign Meningioma

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  • Antibodies
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Sources for Benign Meningioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet