MCID: BNG002
MIFTS: 41

Benign Meningioma malady

Summaries for Benign Meningioma

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33MalaCards
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MalaCards: Benign Meningioma, also known as meningioma, benign, is related to brain meningioma and brain edema. An important gene associated with Benign Meningioma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Cell Cycle and Lagging Strand Synthesis. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and b cells, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Benign Meningioma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

benign meningioma 8 10 45 61
meningioma, benign 8


External Ids:

Disease Ontology8 DOID:4587
MeSH35 D008579
NCIt40 C4055

Related Diseases for Benign Meningioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the meningioma family:

benign meningioma familial meningioma
meningioma, sis-related

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1brain meningioma10.3
2brain edema10.2
3lung meningioma10.0
4skull base meningioma10.0
5ductal carcinoma in situ10.0PGR
6malignant mesothelioma10.0NF2
7tongue cancer10.0TERT
8pancreatitis10.0CTSB
9gingivitis10.0CST3
10cholangiocarcinoma10.0TERT
11uterine sarcoma10.0MDM2
12fibromatosis10.0PGR
13wilms tumor10.0PTN
14hepatitis c10.0CTSB
15papilloma10.0PCNA
16spinal meningioma10.0NF2
17hepatoblastoma10.0BIRC5
18testicular cancer10.0CCNA2
19myoma10.0PGR
20hemangiopericytoma10.0MDM2
21neurofibromatosis10.0NF2
22leiomyosarcoma10.0PGR, MDM2
23teratocarcinoma10.0PLAU
24hepatitis b10.0TERT, CTSB
25actinic keratosis10.0PCNA
26myelodysplastic syndromes10.0BIRC5
27endometriosis10.0PLAU, PGR
28psoriasis10.0CTSL
29cervical adenocarcinoma10.0PGR
30galactosemia10.0PCNA
31keratoacanthoma10.0PCNA, MKI67
32chondrosarcoma10.0PLAU, MDM2
33leukoplakia10.0PCNA, MKI67
34arthritis10.0CTSB, CTSL
35ependymoma10.0MDM2, NF2, MKI67
36myeloma10.0CCNA2, CST3, BIRC5
37skin cancer10.0PCNA
38cervical intraepithelial neoplasia10.0TERT, BIRC5, MKI67
39phyllode tumor10.0PGR, MKI67, CCNA2
40myeloid leukemia10.0CCNA2, BIRC5
41hemangioma10.0SLC2A1, ETS1
42fibrous meningioma10.0NF2, EGFL6
43ataxia telangiectasia10.0MDM2, ETS1
44gastrointestinal stromal tumor10.0NF2, MKI67, PCNA
45malignant peripheral nerve sheath tumor10.0TERT, NF2, MDM2
46anaplastic ependymoma10.0MDM2, NF2
47gastritis10.0PCNA
48adenosarcoma10.0PGR
49meningioma10.0PGR, PCNA, MKI67
50ischemia10.0ETS1, NF2, CST3

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Clinical Features for Benign Meningioma

Drugs & Therapeutics for Benign Meningioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Benign Meningioma

Drug clinical trials:

Search ClinicalTrials for Benign Meningioma

Search NIH Clinical Center for Benign Meningioma

Search CenterWatch for Benign Meningioma

Genetic Tests for Benign Meningioma

Anatomical Context for Benign Meningioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Benign Meningioma:

33
Brain, Lung, B cells, Pituitary

Animal Models for Benign Meningioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Benign Meningioma

Sources:
51PubMed
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Articles related to Benign Meningioma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Pulmonary and Pleural Metastases from Benign Meningeal Meningioma: A Case Report. (23364223)
2013
2
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
3
A rare case of a large spinal meningioma with mediastinal extension and malignant behavior classified histologically as benign. (22918774)
2013
4
Infratentorial benign cystic meningioma mimicking a hemangioblastoma radiologically and a pilocytic astrocytoma intraoperatively: a case report. (23537099)
2013
5
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
6
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
7
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
8
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
9
Stereotactic radiosurgery and radiotherapy in benign intracranial meningioma. (22776812)
2011
10
Is a benign meningioma always an indolent tumor? (21486754)
2011
11
Seeding metastases of a benign intraventricular meningioma along the surgical track. (20036547)
2010
12
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
13
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
14
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. (21509301)
2009
15
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
16
Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. (17962031)
2008
17
Histologically benign intraventricular meningioma with concurrent pulmonary metastasis: case report and review of the literature. (18282656)
2008
18
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
19
Gamma Knife surgery for benign meningioma. (17695387)
2007
20
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
21
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
22
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
23
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
24
Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression. (15540215)
2005
25
Chromosomal and genetic abnormalities in benign and malignant meningiomas using DNA microarray. (16197812)
2005
26
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
27
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
28
Radiotherapy after surgery for benign cerebral meningioma. (15066300)
2004
29
Hormone receptors in benign intracranial meningiomas. (17415829)
2004
30
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
31
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. (12391463)
2002
32
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
33
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
34
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. (12224136)
2002
35
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
36
Meningioma: a cytogenetic model of a complex benign human tumor, including data on 394 karyotyped cases. (11528114)
2001
37
Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas. (11567227)
2001
38
An iatrogenic epidemic of benign meningioma. (10670551)
2000
39
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
40
p53 and PCNA expression in benign, atypical and malignant meningiomas. (10647228)
1999
41
Images in pathology. Benign meningioma. (10458841)
1999
42
Radiotherapy in the treatment of benign meningioma of the skull base. (10223446)
1999
43
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
44
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
45
Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. (9405679)
1997
46
Primary benign tumors of the orbital cavity: comparative data in a series of patients with optic nerve glioma, sheath meningioma, or neurinoma. (8607065)
1996
47
Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas. (8867694)
1995
48
Benign brain tumors. Meningiomas, pituitary tumors, and acoustic neuromas. (8584005)
1995
49
Benign meningioma with a short latency period following irradiation. (1440212)
1992
50
Osseous metastases from a benign intraventricular meningioma. Case report. (1414521)
1992

Genetic Variations for Benign Meningioma

Expression for genes affiliated with Benign Meningioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Benign Meningioma

Search GEO for disease gene expression data for Benign Meningioma.

Pathways for genes affiliated with Benign Meningioma

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Benign Meningioma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Benign Meningioma according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CTSL
2resveratrol45 60 11 2413.5PGR
3diazomethane4510.2SLC2A1, CTSB, CTSL
4etoposide45 50 60 1113.1CCNA2, TERT, CTSB, MDM2
5paclitaxel45 50 1112.1CCNA2, TERT, BIRC5, MDM2, CTSB, PGR
6h2o24510.0PTN, CCNA2, ETS1, PCNA, CTSB
7arsenite45 2411.0PGR, PCNA, MDM2, TERT, BIRC5, CCNA2
8adpribose4510.0BIRC5, MDM2, CCNA2, PCNA, TERT
9kininogen4510.0CSTB, CTSL, CTSB, PLAU, CST3
10camptothecin45 60 1111.9CTSB, PCNA, BIRC5, MDM2, TERT, CCNA2
11thymidylate459.9TERT, BIRC5, PCNA, MKI67, CCNA2, MDM2
12adriamycin459.9PLAU, PGR, MDM2, TERT, BIRC5
13actinidin459.9CTSB, CTSL, CST3
14agar459.8PTN, MDM2, NF2, PGR, BIRC5, SLC2A1
15thapsigargin45 6010.8PLAU, SLC2A1, PCNA, MDM2, CTSB, CCNA2
16dexamethasone45 50 29 1112.8SLC2A1, CCNA2, BIRC5, PCNA, MDM2, CTSL
17leupeptin459.8PLAU, CST3, CTSL, CTSB
18methotrexate45 50 1111.8BIRC5, PGR, CCNA2, MDM2, MKI67, PCNA
19pd 98,059459.8SLC2A1, PLAU, BIRC5, ETS1, TERT, MDM2
20docetaxel45 50 60 1112.8PGR, BIRC5, MDM2, CCNA2, PLAU
21doxorubicin45 50 1111.7CTSB, MDM2, MKI67, CCNA2, TERT, PLAU
22tamoxifen45 50 29 1112.7PGR, HSD17B13, PLAU, BIRC5, PCNA, MKI67
23matrigel459.7CST3, CTSL, CTSB, PTN, ETS1, PLAU
24ly294002459.7PTN, PLAU, SLC2A1, MDM2, CTSB, TERT
25genistein45 29 60 2 11 2414.6MDM2, PCNA, PGR, BIRC5, SLC2A1, PLAU
26cyclosporin a45 29 6011.6CTSB, CCNA2, CTSL, ETS1, PCNA, PGR
27wortmannin459.6TERT, SLC2A1, PLAU, PTN, BIRC5, MDM2
28serine459.6MKI67, NF2, CTSB, CTSL, CSTB, CCNA2
29glucose459.6BIRC5, SLC2A1, CTSB, CST3, HSD17B13, ETS1
30steroid459.5BIRC5, PLAU, HSD17B13, MKI67, CCNA2, MDM2
31aspartate459.5PGR, PLAU, PCNA, MDM2, CCNA2, CTSB
32threonine459.5NF2, TERT, BIRC5, ETS1, MKI67, MDM2
33lactate459.5SLC2A1, CST3, HSD17B13, CTSB, MKI67, BIRC5
345fluorouracil459.5PCNA, TERT, SLC2A1, BIRC5, PGR, CTSB
35testosterone45 60 11 2412.5MDM2, TERT, BIRC5, PGR, PCNA, MKI67
36dutp459.5MDM2, MKI67, PCNA, BIRC5
37estradiol45 11 2411.5HSD17B13, CCNA2, PLAU, BIRC5, PGR, PCNA
38arginine459.4ETS1, PCNA, PLAU, TERT, MDM2, CTSB
39phosphatidylinositol459.4SLC2A1, PTN, ETS1, PLAU, BIRC5, CCNA2
40oligonucleotide459.3CCNA2, TERT, BIRC5, PTN, PCNA, ETS1
41nitric oxide45 11 2411.3ETS1, BIRC5, TERT, MKI67, PTN, CCNA2
42paraffin459.3MDM2, PCNA, PGR, BIRC5, PLAU, TERT
43alanine459.1BIRC5, PLAU, CTSL, PGR, PCNA, ETS1
44cisplatin45 50 60 1112.1CCNA2, CST3, TERT, SLC2A1, PLAU, BIRC5
45thymidine45 2410.1ETS1, PLAU, BIRC5, EPB41L3, PCNA, PTN
46retinoic acid45 2410.1CTSB, CCNA2, CTSL, MKI67, ETS1, PCNA
47cysteine459.0CST3, MDM2, CTSB, CTSL, CSTB, TERT
48progesterone45 60 29 11 2412.9MDM2, PCNA, NF2, BIRC5, PGR, EPB41L3
49tyrosine458.7CTSB, PTN, TERT, SLC2A1, PLAU, BIRC5
50vegf458.7PTN, CTSL, CTSB, MDM2, PLAU, MKI67

GO Terms for genes affiliated with Benign Meningioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome lumenGO:03602110.0CTSB, CTSL
2female pronucleusGO:0019399.9CCNA2, SLC2A1
3nucleoplasmGO:0056549.5CCNA2, MDM2, PCNA, MCM7, PGR, TERT
4nucleolusGO:0057309.2PGR, CSTB, CTSB, MDM2, NF2, MKI67

Biological processes related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to thyroid hormone stimulusGO:09706710.1CTSB, CTSL
2negative regulation of peptidase activityGO:0104669.9CST3, CSTB

Molecular functions related to Benign Meningioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase inhibitor activityGO:00486910.0CSTB, CST3, BIRC5
2protein bindingGO:0055157.5CCNA2, CST3, CTSL, CTSB, MDM2, NF2

Products for genes affiliated with Benign Meningioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Benign Meningioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet