MCID: BNG002
MIFTS: 32

Benign Meningioma malady

Categories: Genetic diseases, Cancer diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Benign Meningioma

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Aliases & Descriptions for Benign Meningioma:

Name: Benign Meningioma 11 50 13 68
 
Meningioma, Benign 11

Classifications:



External Ids:

Disease Ontology11 DOID:4587
MeSH39 D008579
NCIt45 C4055

Summaries for Benign Meningioma

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MalaCards based summary: Benign Meningioma, also known as meningioma, benign, is related to meningioma, familial and extramedullary plasmacytoma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways is Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include brain and lung, and related mouse phenotypes are Increased Nanog expression and Increased cell death HMECs cells.

Related Diseases for Benign Meningioma

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Diseases in the Benign Meningioma family:

Meningioma, Familial

Diseases related to Benign Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma, familial10.9
2extramedullary plasmacytoma10.3MKI67, PCNA
3brachydactyly small stature face anomalies10.2MKI67, PCNA
4oro-mandibular-limb hypogenesis syndrome10.2MKI67, PCNA
5central nervous system tuberculosis10.2MKI67, PGR
6pericardium leiomyoma10.2PCNA, PGR
7lymphomatous thyroiditis10.2PCNA, PGR
8bladder adenocarcinoma10.2MKI67, PGR
9spinal cord oligodendroglioma10.2MKI67, PCNA
10uterine hypoplasia10.2MKI67, PGR
11lichen planus pigmentosus10.2MKI67, PCNA
12cavernous hemangioma of colon10.2NF2, PGR
13classic congenital mesoblastic nephroma10.2NF2, PGR
14rectal neoplasm10.2MKI67, PGR
15porokeratosis10.2NF2, PGR
16ulnar neuropathy10.2NF2, PGR
17leiomyoma10.2NF2, PCNA
18seminoma10.2NF2, PGR
19diphtheria10.2NF2, PGR
20external ear disease10.2NF2, TERT
21his bundle tachycardia10.2MKI67, PGR
22spastic paraplegia 110.2MKI67, TERT
23epidural abscess10.2NF2, PGR
24lung adenoid cystic carcinoma10.1MKI67, PCNA
25struma ovarii10.1MKI67, PGR
26nutmeg liver10.1CTSL, TERT
27immunodeficiency due to a classical component pathway complement deficiency10.1BIRC5, NF2
28trachea sarcoma10.1PGR, TERT
29vaginal adenosarcoma10.1BIRC5, PGR
30glycerol kinase deficiency, adult form10.1PCNA, PGR
31connective tissue cancer10.1NF2, PCNA
32pelvic varices10.1CTSL, TERT
33endocervicitis10.1BIRC5, PGR
34statin toxicity10.1BIRC5, MKI67
35gallbladder papillomatosis10.0BIRC5, PGR
36epimetaphyseal dysplasia cataract10.0MKI67, NF2
37charcot-marie-tooth disease type 2n10.0BIRC5, MKI67, TERT
38kidney benign neoplasm9.9BIRC5, PGR
39nodular cutaneous amyloidosis9.9BIRC5, TERT
40brain edema9.8
41orofaciodigital syndrome iv9.6CTSL, MKI67, NF2, PCNA, PGR, TERT
42cerebral amyloid angiopathy9.6
43cerebritis9.6
44common bile duct neoplasm8.8ARHGAP28, BIRC5, CTSL, HSD17B13, MKI67, NF2

Graphical network of the top 20 diseases related to Benign Meningioma:



Diseases related to benign meningioma

Symptoms & Phenotypes for Benign Meningioma

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GenomeRNAi Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00371-A-59.7BIRC5, MKI67, PCNA
2GR00103-A-09.3BIRC5, CTSL, PCNA, PGR

MGI Mouse Phenotypes related to Benign Meningioma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.5ARHGAP28, BIRC5, HSD17B13, MKI67, PGR, TERT

Drugs & Therapeutics for Benign Meningioma

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Drugs for Benign Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
HydroxyureaapprovedPhase 2223127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
2
Lapatinibapproved, investigational, Approved March 2007Phase 2301231277-92-2, 388082-78-8208908, 9941095
Synonyms:
1xkk
231277-92-2
388082-78-8
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
AB1004631
AC-1314
AC1L4LL4
AKOS005145766
CHEBI:49603
CHEMBL1201179
CHEMBL554
CID11557040
CID208908
D04024
D08108
DB01259
DB02584
EN002712
FMM
GSK 572016
GSK572016
GW 572016
GW 572016X
GW-2016
GW-572016
GW-572016F
GW2016
GW572016
HMS2089H10
I01-1247
 
Kinome_3684
Kinome_3685
LAPATINIB DITOSYLATE MONOHYDRATE
LS-187029
LS-187771
Lapatinib
Lapatinib (INN)
Lapatinib Ditosylate
Lapatinib [INN]
Lapatinib ditosylate
Lapatinib ditosylate (USAN)
Lapatinib tosilate hydrate
Lapatinib tosilate hydrate (JAN)
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
NCGC00167507-01
NSC745750
TL80090051
Tycerb
Tykerb
Tykerb (TN)
Tyverb
UNII-0VUA21238F
lapatinib
lapatinib ditosylate
nchembio866-comp20
3Iron-Dextran ComplexPhase 275
4Protein Kinase InhibitorsPhase 23689
5interferonsPhase 22175
6Nucleic Acid Synthesis InhibitorsPhase 24962
7Interferon-alphaPhase 21152
8Anti-Infective AgentsPhase 222062
9Antiviral AgentsPhase 29967
10
Pioglitazoneapproved, investigationalPhase 1441111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
11Hypoglycemic AgentsPhase 15896

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain TumorsUnknown statusNCT00517959Phase 3
2Proton/Photon Rt - Benign Meningiomas(P92-13)CompletedNCT02947984Phase 3
3Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by SurgeryTerminatedNCT00104936Phase 3
4S9811 Hydroxyurea in Treating Patients With Unresectable Benign MeningiomaCompletedNCT00003590Phase 2
5Interferon Alfa in Treating Patients With Recurrent Unresectable Meningiomas and Malignant MeningiomasCompletedNCT00002965Phase 2
6Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related TumorsCompletedNCT00973739Phase 2
7Multisession Radiosurgery for Optic Nerve Sheath MeningiomasRecruitingNCT02594709Phase 2
8Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain TumorsCompletedNCT01151670Phase 1
9Analysis of NF2 Mutations in Radiation-Related Neural TumorsCompletedNCT00340496
10A Family Study of Adults With GliomaCompletedNCT00339352
11A Case-Referent Study of Brain Tumors in AdultsCompletedNCT00339300
12Multisession Radiosurgery in Large MeningiomasActive, not recruitingNCT02974127
13Stereotactic Body Radiotherapy for Spine TumorsActive, not recruitingNCT01347307
14Risk Factors for Adult-Onset Brain TumorsTerminatedNCT00592865

Search NIH Clinical Center for Benign Meningioma

Genetic Tests for Benign Meningioma

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Anatomical Context for Benign Meningioma

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MalaCards organs/tissues related to Benign Meningioma:

36
Brain, Lung

Publications for Benign Meningioma

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Articles related to Benign Meningioma:

(show all 44)
idTitleAuthorsYear
1
Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. (27815026)
2017
2
Review of controversies in management of non-benign meningioma. (27338209)
2016
3
Invasive benign meningioma: Clinical characteristics, surgical strategies and outcomes from a single neurosurgical institute. (27284345)
2016
4
A case of benign meningioma presented with subdural hemorrhage. (25977904)
2015
5
Cerebral amyloid angiopathy-related infarcts imitating high-grade differentiation of a benign meningioma. (26385916)
2015
6
Stereotactic radiotherapy of benign meningioma in the elderly: clinical outcome and toxicity in 121 patients. (24813096)
2014
7
Stereotactic radiation therapy for benign meningioma: long-term outcome in 318 patients. (24751409)
2014
8
Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. (23840654)
2013
9
Analysis of gene expression profiling in meningioma: deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum. (23285163)
2012
10
Impaired survival and long-term neurological problems in benign meningioma. (22406926)
2012
11
Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. (22285662)
2012
12
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. (22420586)
2012
13
Is a benign meningioma always an indolent tumor? (21486754)
2011
14
Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. (20428925)
2010
15
Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging. (20819539)
2010
16
Benign meningioma developing late lung metastases: case report and review of the literature. (19919820)
2009
17
How a Brain Tumour took over my Life: Diagnosis and removal of a benign meningioma. (21509301)
2009
18
Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence. (18586307)
2008
19
Iatrogenic metastasis of a benign meningioma to the periosteum at the site of previous craniotomy: a case report. (19122989)
2008
20
Gamma Knife surgery for benign meningioma. (17695387)
2007
21
Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? (17961045)
2007
22
Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. (15980114)
2006
23
Protein p62 common in invaginations in benign meningiomas--a possible predictor of malignancy. (16465773)
2006
24
PCNA, Ki-67 and hTERT in residual benign meningiomas. (16634530)
2006
25
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. (16029801)
2005
26
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas. (15832773)
2005
27
Proliferation and progesterone receptor status in benign meningiomas are not age dependent. (15952201)
2005
28
Establishment of a benign meningioma cell line by hTERT-mediated immortalization. (15965488)
2005
29
Expression of extracellular matrix markers in benign meningiomas. (14719542)
2003
30
Expression of the inhibitor of apoptosis protein survivin in benign meningiomas. (12706880)
2003
31
Overexpression of mdm2 and p53 and association with progesterone receptor expression in benign meningiomas. (12416559)
2002
32
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein. (11928726)
2002
33
Benign meningioma metastasizing through CSF pathways: a case report and review of literature. (12391463)
2002
34
The impact of progesterone receptor expression on relapse in the long-term clinical course of 93 benign meningiomas. (12224136)
2002
35
Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence. (11299001)
2001
36
Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? (10701525)
2000
37
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. (11121635)
2000
38
An iatrogenic epidemic of benign meningioma. (10670551)
2000
39
Images in pathology. Benign meningioma. (10458841)
1999
40
Radiotherapy in the treatment of benign meningioma of the skull base. (10223446)
1999
41
Increased proliferative activity due to necroses induced by pre-operative embolization in benign meningiomas. (10066099)
1998
42
Hemangiopericytoma arising at the site of a dural graft 13 years after total removal of a benign meningioma--case report. (9919906)
1998
43
Prediction of recurrence in histologically benign meningiomas: proliferating cell nuclear antigen and Ki-67 immunohistochemical study. (9352816)
1997
44
Benign meningioma with a short latency period following irradiation. (1440212)
1992

Variations for Benign Meningioma

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Expression for genes affiliated with Benign Meningioma

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Search GEO for disease gene expression data for Benign Meningioma.

Pathways for genes affiliated with Benign Meningioma

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Pathways related to Benign Meningioma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.0CTSL, MKI67, PCNA

GO Terms for genes affiliated with Benign Meningioma

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Biological processes related to Benign Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein stabilityGO:003164710.2NF2, TERT
2response to cadmium ionGO:00466869.9PCNA, TERT
3telomere maintenanceGO:00007239.4PCNA, TERT

Molecular functions related to Benign Meningioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.0BIRC5, PCNA, PGR

Sources for Benign Meningioma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet