MCID: BNG041
MIFTS: 43

Benign Metastasizing Leiomyoma malady

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Summaries for Benign Metastasizing Leiomyoma

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MalaCards: Benign Metastasizing Leiomyoma is related to leiomyoma and leiomyomatosis. An important gene associated with Benign Metastasizing Leiomyoma is DES (desmin), and among its related pathways are Aurora B signaling and Ovarian Infertility Genes. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and spinal cord, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Benign Metastasizing Leiomyoma

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43NIH Rare Diseases
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Classifications:

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Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

benign metastasizing leiomyoma 43


Related Diseases for Benign Metastasizing Leiomyoma

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17GeneCards, 18GeneDecks
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Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyoma31.5VIM, ESR1, PGR, CYP19A1, DES, LGALS1
2leiomyomatosis31.0ESR1, PGR
3lymphangioleiomyomatosis30.7DES, PGR, ESR1
4myoma30.3CYP19A1, PGR, ESR1
5lung cancer30.3LGALS1, BCL2, KRT7
6intravenous leiomyomatosis10.4
7mediastinitis10.2
8pancreatitis10.2
9infantile myofibromatosis10.1DES
10metanephric adenoma10.1KRT7
11fasciitis10.1ACTC1
12cystadenoma10.1KRT7
13pseudomyxoma peritonei10.1KRT7
14cerebral meningioma10.1PGR
15adenomatoid tumor10.1VIM
16desmoid tumor10.1DES, ACTC1
17cutaneous fibrous histiocytoma10.1DES, ACTC1
18embryonal rhabdomyosarcoma10.1DES, ACTC1
19sertoli-leydig cell tumor10.1PGR, KRT7
20mucoepidermoid carcinoma10.1KRT7, ACTC1
21mesenchymal chondrosarcoma10.1DES, VIM
22ductal carcinoma in situ10.1PGR, ESR1
23secretory meningioma10.1VIM, KRT7
24estrogen excess10.1CYP19A1, PGR
25alveolar soft part sarcoma10.1DES, VIM
26meningioma10.1PGR, ESR1
27cribriform carcinoma10.1PGR, ESR1
28progesterone resistance10.1PGR, ESR1
29bilateral breast cancer10.1PGR, ESR1
30adenosquamous carcinoma10.1PGR, KRT7
31granular cell tumor10.1DES, VIM
32male breast cancer10.0PGR, ESR1
33myoepithelioma10.0VIM, ACTC1
34li-fraumeni syndrome10.0PGR, ESR1
35epithelioid sarcoma10.0VIM, KRT7
36endocrine gland cancer10.0CYP19A1, ESR1
37uterine fibroid10.0PGR, ESR1
38inflammatory breast carcinoma10.0ESR1, PGR
39phyllode tumor10.0PGR, VIM
40angiosarcoma10.0ACTC1, VIM
41breast fibroadenoma10.0ESR1, PGR
42malignant peripheral nerve sheath tumor10.0VIM, ACTC1
43ovarian disease10.0ESR1, CYP19A1
44leydig cell tumor10.0LGALS1, CYP19A1
45teratoma10.0KRT7, ACTC1
46neurofibroma10.0VIM, ACTC1
47epithelioid leiomyosarcoma10.0ACTC1, VIM, DES
48pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
49osteoporosis, postmenopausal10.0ESR1, CYP19A1
50dermatofibrosarcoma protuberans10.0DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Symptoms for Benign Metastasizing Leiomyoma

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Drugs & Therapeutics for Benign Metastasizing Leiomyoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Benign Metastasizing Leiomyoma

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Anatomical Context for Benign Metastasizing Leiomyoma

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MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

33
Lung, Uterus, Spinal cord, Ovary, Lymph node, Breast, Skeletal muscle

Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3BCL2, LGALS1, ESR1, PGR, CYP19A1
2MP:00053857.9DES, CYP19A1, PGR, ESR1, VIM, ACTC1
3MP:00053897.9CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
4MP:00053767.7DES, CYP19A1, PGR, ESR1, VIM, ACTC1
5MP:00053867.7DES, CYP19A1, PGR, ESR1, VIM, LGALS1
6MP:00053877.5CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
7MP:00107687.5DES, PGR, ESR1, VIM, LGALS1, ACTC1
8MP:00053697.4BCL2, DES, CYP19A1, PGR, ESR1, VIM
9MP:00053847.3CYP19A1, PGR, ESR1, VIM, ACTC1, BCL2

Publications for Benign Metastasizing Leiomyoma

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52PubMed
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Articles related to Benign Metastasizing Leiomyoma:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis. (24272622)
2014
2
Benign metastasizing leiomyoma of the lung: report of a case. (23117336)
2013
3
A rare pancreatic tumor in a 52-year-old Chinese woman. Pancreatic benign metastasizing leiomyoma. (23333466)
2013
4
Pulmonary benign metastasizing leiomyoma: report of three cases. (24139514)
2013
5
Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review. (23465706)
2013
6
Elevated 99mTc 3PRGD2 activity in benign metastasizing leiomyoma. (23334126)
2013
7
Benign metastasizing leiomyoma : Case report and review of the literature. (23903362)
2013
8
Multifocal osteolytic lesions within lumbar spine in a middle-aged Chinese woman: a benign metastasizing leiomyoma? (21857396)
2012
9
Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. (22632533)
2012
10
Favorable response to antigonadal therapy for a benign metastasizing leiomyoma. (22270431)
2012
11
Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. (23234399)
2012
12
Benign metastasizing leiomyoma of the lung. (21959195)
2012
13
FDG-PET/CT finding of benign metastasizing leiomyoma of the lung. (23986835)
2012
14
Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. (21811430)
2011
15
Serial spread of benign metastasizing leiomyoma to the thoracic spine. (21658956)
2011
16
Pulmonary and retroperitoneal benign metastasizing leiomyoma. (22384439)
2011
17
Benign metastasizing leiomyoma - case report and review of literature. (21835535)
2011
18
Benign metastasizing leiomyoma of external iliac vessels: an unusual case report. (20800337)
2011
19
Benign metastasizing leiomyoma identified using 18F-FDG PET/CT. (20435308)
2010
20
Pathogenesis of benign metastasizing leiomyoma: a review. (20214834)
2010
21
Benign metastasizing leiomyoma: report of two cases and literature review. (21163149)
2010
22
Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle. (20103256)
2010
23
A benign metastasizing leiomyoma involving a nodule in the pulmonary artery: case and literature review. (21077481)
2010
24
Benign metastasizing leiomyoma of the lung: PET findings. (19242303)
2009
25
A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole. (18523791)
2009
26
Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma? (19331193)
2009
27
Benign metastasizing leiomyoma: report of 2 cases and review of the literature. (19771765)
2009
28
Benign metastasizing leiomyoma of the lung: potential role of low-grade malignancy. (19330762)
2009
29
Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy. (18259767)
2008
30
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. (18382364)
2008
31
Benign metastasizing leiomyoma of the uterus. (17198463)
2007
32
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. (16357844)
2006
33
Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature. (16343217)
2005
34
Pulmonary benign metastasizing leiomyoma from the uterus in a postmenopausal woman: report of a case. (14714229)
2004
35
Benign metastasizing leiomyoma and lymphangioleiomyomatosis: sex-specific diseases? (15099894)
2004
36
Benign metastasizing leiomyoma to skull base and spine: a report of two cases. (12860509)
2003
37
Benign metastasizing leiomyoma causing spinal cord compression. (14670684)
2003
38
Benign metastasizing leiomyoma. (11972229)
2002
39
Benign metastasizing leiomyoma of the lung: a case report. (11155751)
2000
40
Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. (11037349)
2000
41
Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. (10506455)
1999
42
Pulmonary leiomyomatosis in women after hysterectomy for uterine myoma. Benign metastasizing leiomyoma? (10439097)
1999
43
Benign metastasizing leiomyoma in the lung. (9599398)
1998
44
Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. (8739468)
1996
45
Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. (21594362)
1996
46
Fine needle aspiration diagnosis of benign metastasizing leiomyoma of the lung. A case report. (8191830)
1994
47
Benign metastasizing leiomyoma. (3800475)
1987
48
Use of LHRH analogue to obtain reversible castration in a patient with benign metastasizing leiomyoma. (3085706)
1986
49
Benign metastasizing leiomyoma. (6703252)
1984
50
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. (7242600)
1981

Variations for Benign Metastasizing Leiomyoma

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Expression for genes affiliated with Benign Metastasizing Leiomyoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Metastasizing Leiomyoma

Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 60Thomson Reuters, 30KEGG, 53QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Benign Metastasizing Leiomyoma

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45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1orcein459.8VIM, ACTC1, DES
2s 100459.8VIM, DES, ACTC1
3idoxifene459.7CYP19A1, PGR, ESR1
4estradiol benzoate459.6PGR, ESR1, CYP19A1
5nandrolone45 2410.6CYP19A1, PGR, ESR1
6goserelin45 29 1111.6ESR1, PGR, CYP19A1
7megestrol acetate459.6CYP19A1, ESR1, PGR
8leuprolide acetate459.6CYP19A1, PGR, ESR1
9exemestane45 51 61 1112.6ESR1, CYP19A1, PGR
10anastrozole45 51 1111.5PGR, CYP19A1, ESR1
11bisphenol a459.5CYP19A1, ESR1, PGR
12lapatinib45 51 1111.5PGR, CYP19A1, ESR1
13clomiphene citrate459.5CYP19A1, PGR, ESR1
14toremifene45 1110.5ESR1, PGR, CYP19A1
15tibolone459.4ESR1, CYP19A1, PGR
16danazol45 24 1111.4CYP19A1, ESR1, PGR
17fulvestrant45 51 29 1112.4ESR1, CYP19A1, PGR
18letrozole45 51 61 1112.3ESR1, CYP19A1, PGR
19levonorgestrel45 61 29 1112.3CYP19A1, PGR, ESR1
20procollagen459.3VIM, DES, LGALS1, ACTC1
21adriamycin459.2DES, PGR, VIM, BCL2
224-hydroxytamoxifen459.2ESR1, PGR, VIM, CYP19A1
23taxane459.2CYP19A1, BCL2, ESR1, PGR
24n-(4-hydroxyphenyl)retinamide459.1BCL2, VIM, ESR1, CYP19A1
25reticulin459.1VIM, ACTC1, KRT7, DES
26mucicarmine459.1KRT7, ACTC1, VIM, DES
27b 723459.0KRT7, ACTC1, VIM, DES
28hematoxylin459.0DES, KRT7, ACTC1, VIM
29docetaxel45 51 61 1112.0ESR1, CYP19A1, BCL2, PGR
30progestin459.0CYP19A1, PGR, ESR1, VIM, DES
31dihydrotestosterone45 29 24 1111.9CYP19A1, DES, PGR, VIM, ESR1
32flutamide45 61 1110.9PGR, CYP19A1, ESR1
33estradiol45 24 1110.9DES, CYP19A1, PGR, ESR1, VIM
34cyclophosphamide45 51 1110.8ESR1, CYP19A1, BCL2, PGR
35tamoxifen45 51 29 1111.7CYP19A1, ESR1, BCL2, VIM, PGR
36paclitaxel45 51 1110.7BCL2, VIM, ESR1, CYP19A1, PGR
37genistein45 29 61 3 24 1113.7CYP19A1, PGR, VIM, BCL2, ESR1
38formaldehyde45 249.7DES, CYP19A1, VIM, ACTC1, KRT7
39doxorubicin45 51 1110.5BCL2, DES, VIM, CYP19A1, ESR1, PGR
40dexamethasone45 51 29 1111.4BCL2, CYP19A1, PGR, ACTC1, VIM, LGALS1
41methotrexate51 45 1110.4KRT7, VIM, ESR1, PGR, CYP19A1
42cycloheximide458.4PGR, ESR1, BCL2, VIM, CYP19A1
435-aza-2deoxycytidine458.3ESR1, VIM, KRT7, PGR
44retinoid457.8PGR, ESR1, VIM, KRT7, BCL2, LGALS1
45testosterone45 61 24 1110.8VIM, ACTC1, KRT7, ESR1, PGR, CYP19A1
46vegf457.7KRT7, ESR1, DES, BCL2, PGR, VIM
47progesterone45 29 61 24 1111.4KRT7, VIM, BCL2, DES, CYP19A1, PGR
48retinoic acid45 248.4PGR, ESR1, KRT7, VIM, ACTC1, CYP19A1
49paraffin457.2DES, VIM, KRT7, PGR, BCL2, ACTC1
50estrogen456.9DES, CYP19A1, PGR, ESR1, VIM, LGALS1

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

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16Gene Ontology
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Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT7, VIM, DES

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.6ESR1, CYP19A1
2muscle filament slidingGO:0300499.5ACTC1, VIM, DES
3negative regulation of neuron projection developmentGO:0109779.2LGALS1, VIM
4response to drugGO:0424939.2BCL2, ACTC1, LGALS1
5apoptotic processGO:0069158.7VIM, LGALS1, ACTC1, BCL2

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.6ESR1, PGR
2steroid bindingGO:0054969.5PGR, ESR1
3glycoprotein bindingGO:0019489.2LGALS1, VIM
4identical protein bindingGO:0428028.8BCL2, VIM, ESR1, DES

Products for genes affiliated with Benign Metastasizing Leiomyoma

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Sources for Benign Metastasizing Leiomyoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet