MCID: BNG041
MIFTS: 39

Benign Metastasizing Leiomyoma malady

Rare diseases, Cancer diseases categories

Summaries for Benign Metastasizing Leiomyoma

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MalaCards based summary: Benign Metastasizing Leiomyoma, also known as benign metastasizing leiomyoma of uterus, is related to leiomyomatosis and lymphangioleiomyomatosis. An important gene associated with Benign Metastasizing Leiomyoma is DES (desmin), and among its related pathways are Aurora B signaling and Ovarian Infertility Genes. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include uterus, lung and bone, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Benign Metastasizing Leiomyoma

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Benign Metastasizing Leiomyoma, Aliases & Descriptions:

Name: Benign Metastasizing Leiomyoma 41
 
Benign Metastasizing Leiomyoma of Uterus 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Benign Metastasizing Leiomyoma

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Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis31.3PGR, ESR1
2lymphangioleiomyomatosis30.9PGR, ESR1, DES
3leiomyoma30.8CYP19A1, PGR, ESR1, VIM, LGALS1, DES
4myoma30.4ESR1, PGR, CYP19A1
5sarcoma30.2DES, VIM, LGALS1, ACTC1
6lung cancer30.1KRT7, BCL2, LGALS1
7infantile myofibromatosis10.5DES
8metanephric adenoma10.5KRT7
9fasciitis10.5ACTC1
10intravenous leiomyomatosis10.5
11cystadenoma10.5KRT7
12pseudomyxoma peritonei10.4KRT7
13cerebral meningioma10.4PGR
14adenomatoid tumor10.4VIM
15desmoid disease, hereditary10.4DES, ACTC1
16cutaneous fibrous histiocytoma10.3DES, ACTC1
17embryonal rhabdomyosarcoma10.3DES, ACTC1
18sertoli-leydig cell tumor10.3PGR, KRT7
19mucoepidermoid carcinoma10.3ACTC1, KRT7
20mesenchymal chondrosarcoma10.2VIM, DES
21secretory meningioma10.2VIM, KRT7
22ductal carcinoma in situ10.2PGR, ESR1
23estrogen excess10.2CYP19A1, PGR
24alveolar soft-part sarcoma10.2DES, VIM
25meningioma, familial10.2PGR, ESR1
26cribriform carcinoma10.2PGR, ESR1
27arteriovenous malformation10.2
28mediastinitis10.2
29pancreatitis10.2
30pneumothorax10.2
31pulmonary arteriovenous malformation10.2
32spontaneous pneumothorax10.2
33progesterone resistance10.2PGR, ESR1
34bilateral breast cancer10.2PGR, ESR1
35adenosquamous carcinoma10.2PGR, KRT7
36granular cell tumor10.2DES, VIM
37breast disease10.2PGR, ESR1
38myoepithelioma10.2VIM, ACTC1
39endocrine gland cancer10.2CYP19A1, ESR1
40epithelioid sarcoma10.2VIM, KRT7
41uterine fibroid10.2ESR1, PGR
42inflammatory breast carcinoma10.2PGR, ESR1
43benign breast phyllodes tumor10.2VIM, PGR
44breast ductal carcinoma10.2PGR, ESR1
45angiosarcoma10.2ACTC1, VIM
46breast fibroadenoma10.2ESR1, PGR
47malignant peripheral nerve sheath tumor10.2ACTC1, VIM
48ovarian disease10.2CYP19A1, ESR1
49leydig cell tumor10.1LGALS1, CYP19A1
50teratoma10.1KRT7, ACTC1

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Symptoms for Benign Metastasizing Leiomyoma

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Drugs & Therapeutics for Benign Metastasizing Leiomyoma

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Drug clinical trials:

Search ClinicalTrials for Benign Metastasizing Leiomyoma

Search NIH Clinical Center for Benign Metastasizing Leiomyoma

Genetic Tests for Benign Metastasizing Leiomyoma

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Anatomical Context for Benign Metastasizing Leiomyoma

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MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

31
Uterus, Lung, Bone, Lymph node, Spinal cord, Breast, Ovary, Skeletal muscle

Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

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MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3ESR1, BCL2, CYP19A1, LGALS1, PGR
2MP:00053857.9CYP19A1, PGR, BCL2, ACTC1, DES, VIM
3MP:00053897.9BCL2, CYP19A1, PGR, ESR1, VIM, LGALS1
4MP:00053767.7VIM, ESR1, BCL2, ACTC1, DES, CYP19A1
5MP:00053867.7DES, PGR, ESR1, VIM, LGALS1, BCL2
6MP:00053877.5LGALS1, CYP19A1, VIM, ESR1, PGR, BCL2
7MP:00107687.5BCL2, LGALS1, ESR1, ACTC1, DES, VIM
8MP:00053697.4PGR, BCL2, CYP19A1, DES, LGALS1, ACTC1
9MP:00053847.3BCL2, CYP19A1, PGR, ESR1, VIM, ACTC1

Publications for Benign Metastasizing Leiomyoma

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Articles related to Benign Metastasizing Leiomyoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
What are MRI findings of Spine Benign Metastasizing Leiomyoma? Case report with literature review. (25632838)
2015
2
Incidental benign metastasizing leiomyoma in a patient with bone sarcoma: a case report. (25221682)
2014
3
Pulmonary benign metastasizing leiomyoma: a case report and literature review. (24977035)
2014
4
Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis. (24272622)
2014
5
Benign metastasizing leiomyoma of the lung: report of a case. (23117336)
2013
6
Benign metastasizing leiomyoma of the lung with spontaneous pneumothorax. (25360407)
2013
7
A rare pancreatic tumor in a 52-year-old Chinese woman. Pancreatic benign metastasizing leiomyoma. (23333466)
2013
8
Pulmonary benign metastasizing leiomyoma: report of three cases. (24139514)
2013
9
Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review. (23465706)
2013
10
Elevated 99mTc 3PRGD2 activity in benign metastasizing leiomyoma. (23334126)
2013
11
Benign metastasizing leiomyoma : Case report and review of the literature. (23903362)
2013
12
Multifocal osteolytic lesions within lumbar spine in a middle-aged Chinese woman: a benign metastasizing leiomyoma? (21857396)
2012
13
Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. (22632533)
2012
14
Favorable response to antigonadal therapy for a benign metastasizing leiomyoma. (22270431)
2012
15
Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. (23234399)
2012
16
Benign metastasizing leiomyoma of the lung. (21959195)
2012
17
Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. (21811430)
2011
18
Serial spread of benign metastasizing leiomyoma to the thoracic spine. (21658956)
2011
19
Pulmonary and retroperitoneal benign metastasizing leiomyoma. (22384439)
2011
20
Benign metastasizing leiomyoma - case report and review of literature. (21835535)
2011
21
Benign metastasizing leiomyoma of external iliac vessels: an unusual case report. (20800337)
2011
22
Benign metastasizing leiomyoma identified using 18F-FDG PET/CT. (20435308)
2010
23
Pathogenesis of benign metastasizing leiomyoma: a review. (20214834)
2010
24
Benign metastasizing leiomyoma: report of two cases and literature review. (21163149)
2010
25
Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle. (20103256)
2010
26
Benign metastasizing leiomyoma of the lung: PET findings. (19242303)
2009
27
A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole. (18523791)
2009
28
Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma? (19331193)
2009
29
Benign metastasizing leiomyoma: report of 2 cases and review of the literature. (19771765)
2009
30
Benign metastasizing leiomyoma of the lung: potential role of low-grade malignancy. (19330762)
2009
31
Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy. (18259767)
2008
32
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. (18382364)
2008
33
Benign metastasizing leiomyoma of the uterus. (17198463)
2007
34
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. (16357844)
2006
35
Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature. (16343217)
2005
36
Pulmonary benign metastasizing leiomyoma from the uterus in a postmenopausal woman: report of a case. (14714229)
2004
37
Benign metastasizing leiomyoma to skull base and spine: a report of two cases. (12860509)
2003
38
Benign metastasizing leiomyoma causing spinal cord compression. (14670684)
2003
39
Benign metastasizing leiomyoma in the lung: a case report. (12440822)
2002
40
Benign metastasizing leiomyoma of the lung: a case report. (11155751)
2000
41
Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. (11037349)
2000
42
Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. (10506455)
1999
43
Pulmonary leiomyomatosis in women after hysterectomy for uterine myoma. Benign metastasizing leiomyoma? (10439097)
1999
44
Benign metastasizing leiomyoma in the lung. (9599398)
1998
45
Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. (8739468)
1996
46
Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. (21594362)
1996
47
Fine needle aspiration diagnosis of benign metastasizing leiomyoma of the lung. A case report. (8191830)
1994
48
Use of LHRH analogue to obtain reversible castration in a patient with benign metastasizing leiomyoma. (3085706)
1986
49
Benign metastasizing leiomyoma. (6703252)
1984
50
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. (7242600)
1981

Variations for Benign Metastasizing Leiomyoma

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Expression for genes affiliated with Benign Metastasizing Leiomyoma

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Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

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Compounds for genes affiliated with Benign Metastasizing Leiomyoma

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Compounds related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1orcein439.8VIM, ACTC1, DES
2s 100439.8VIM, DES, ACTC1
3idoxifene439.7CYP19A1, PGR, ESR1
4estradiol benzoate439.6PGR, ESR1, CYP19A1
5nandrolone43 2410.6CYP19A1, PGR, ESR1
6goserelin43 28 1211.6ESR1, PGR, CYP19A1
7megestrol acetate439.6CYP19A1, ESR1, PGR
8leuprolide acetate439.6CYP19A1, PGR, ESR1
9exemestane43 49 59 1212.6ESR1, CYP19A1, PGR
10anastrozole43 49 1211.5PGR, CYP19A1, ESR1
11bisphenol a439.5CYP19A1, ESR1, PGR
12lapatinib43 49 1211.5PGR, CYP19A1, ESR1
13clomiphene citrate439.5CYP19A1, PGR, ESR1
14toremifene43 1210.5ESR1, PGR, CYP19A1
15tibolone439.4ESR1, CYP19A1, PGR
16danazol43 24 1211.4CYP19A1, ESR1, PGR
17fulvestrant43 49 28 1212.4ESR1, CYP19A1, PGR
18letrozole43 49 59 1212.3ESR1, CYP19A1, PGR
19levonorgestrel43 59 28 1212.3CYP19A1, PGR, ESR1
20procollagen439.3VIM, DES, LGALS1, ACTC1
21adriamycin439.2DES, PGR, VIM, BCL2
224-hydroxytamoxifen439.2ESR1, PGR, VIM, CYP19A1
23taxane439.2CYP19A1, BCL2, ESR1, PGR
24n-(4-hydroxyphenyl)retinamide439.1BCL2, VIM, ESR1, CYP19A1
25reticulin439.1VIM, ACTC1, KRT7, DES
26mucicarmine439.1KRT7, ACTC1, VIM, DES
27b 723439.0KRT7, ACTC1, VIM, DES
28hematoxylin439.0DES, KRT7, ACTC1, VIM
29docetaxel43 49 59 1212.0ESR1, CYP19A1, BCL2, PGR
30progestin439.0CYP19A1, PGR, ESR1, VIM, DES
31dihydrotestosterone43 28 24 1211.9CYP19A1, DES, PGR, VIM, ESR1
32flutamide43 59 1210.9PGR, CYP19A1, ESR1
33estradiol43 24 1210.9DES, CYP19A1, PGR, ESR1, VIM
34cyclophosphamide43 49 1210.8ESR1, CYP19A1, BCL2, PGR
35tamoxifen43 49 28 1211.7CYP19A1, ESR1, BCL2, VIM, PGR
36paclitaxel43 49 1210.7BCL2, VIM, ESR1, CYP19A1, PGR
37genistein43 28 59 2 24 1213.7CYP19A1, PGR, VIM, BCL2, ESR1
38formaldehyde43 249.7DES, CYP19A1, VIM, ACTC1, KRT7
39doxorubicin43 49 1210.5BCL2, DES, VIM, CYP19A1, ESR1, PGR
40dexamethasone43 49 28 1211.4BCL2, CYP19A1, PGR, ACTC1, VIM, LGALS1
41methotrexate49 43 1210.4KRT7, VIM, ESR1, PGR, CYP19A1
42cycloheximide438.4PGR, ESR1, BCL2, VIM, CYP19A1
435-aza-2deoxycytidine438.3ESR1, VIM, KRT7, PGR
44retinoid437.8PGR, ESR1, VIM, KRT7, BCL2, LGALS1
45testosterone43 59 24 1210.8VIM, ACTC1, KRT7, ESR1, PGR, CYP19A1
46vegf437.7KRT7, ESR1, DES, BCL2, PGR, VIM
47progesterone43 28 59 24 1211.4KRT7, VIM, BCL2, DES, CYP19A1, PGR
48retinoic acid43 248.4PGR, ESR1, KRT7, VIM, ACTC1, CYP19A1
49paraffin437.2DES, VIM, KRT7, PGR, BCL2, ACTC1
50estrogen436.9DES, CYP19A1, PGR, ESR1, VIM, LGALS1

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

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Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058828.9KRT7, VIM, DES

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00082099.6ESR1, CYP19A1
2muscle filament slidingGO:00300499.5DES, VIM, ACTC1
3negative regulation of neuron projection developmentGO:00109779.2VIM, LGALS1
4response to drugGO:00424939.2BCL2, ACTC1, LGALS1
5apoptotic processGO:00069158.7BCL2, ACTC1, LGALS1, VIM

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.6PGR, ESR1
2steroid bindingGO:00054969.5PGR, ESR1
3glycoprotein bindingGO:00019489.2VIM, LGALS1
4identical protein bindingGO:00428028.8DES, ESR1, VIM, BCL2

Products for genes affiliated with Benign Metastasizing Leiomyoma

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Sources for Benign Metastasizing Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet