MCID: BNG041
MIFTS: 43

Benign Metastasizing Leiomyoma malady

Rare diseases, Cancer diseases categories

Summaries for Benign Metastasizing Leiomyoma

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Benign Metastasizing Leiomyoma is related to leiomyoma and leiomyomatosis. An important gene associated with Benign Metastasizing Leiomyoma is DES (desmin), and among its related pathways are Aurora B signaling and Ovarian Infertility Genes. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and spinal cord, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Benign Metastasizing Leiomyoma

About this section
Sources:
44NIH Rare Diseases
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

benign metastasizing leiomyoma 44


Related Diseases for Benign Metastasizing Leiomyoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyoma31.5VIM, ESR1, PGR, CYP19A1, DES, LGALS1
2leiomyomatosis31.0ESR1, PGR
3lymphangioleiomyomatosis30.7DES, PGR, ESR1
4myoma30.3CYP19A1, PGR, ESR1
5lung cancer30.3LGALS1, BCL2, KRT7
6intravenous leiomyomatosis10.4
7mediastinitis10.2
8pancreatitis10.2
9infantile myofibromatosis10.1DES
10metanephric adenoma10.1KRT7
11fasciitis10.1ACTC1
12cystadenoma10.1KRT7
13pseudomyxoma peritonei10.1KRT7
14cerebral meningioma10.1PGR
15adenomatoid tumor10.1VIM
16desmoid tumor10.1DES, ACTC1
17cutaneous fibrous histiocytoma10.1DES, ACTC1
18embryonal rhabdomyosarcoma10.1DES, ACTC1
19sertoli-leydig cell tumor10.1PGR, KRT7
20mucoepidermoid carcinoma10.1KRT7, ACTC1
21mesenchymal chondrosarcoma10.1DES, VIM
22ductal carcinoma in situ10.1PGR, ESR1
23secretory meningioma10.1VIM, KRT7
24estrogen excess10.1CYP19A1, PGR
25alveolar soft part sarcoma10.1DES, VIM
26meningioma10.1PGR, ESR1
27cribriform carcinoma10.1PGR, ESR1
28progesterone resistance10.1PGR, ESR1
29bilateral breast cancer10.1PGR, ESR1
30adenosquamous carcinoma10.1PGR, KRT7
31granular cell tumor10.1DES, VIM
32male breast cancer10.0PGR, ESR1
33myoepithelioma10.0VIM, ACTC1
34li-fraumeni syndrome10.0PGR, ESR1
35epithelioid sarcoma10.0VIM, KRT7
36endocrine gland cancer10.0CYP19A1, ESR1
37uterine fibroid10.0PGR, ESR1
38inflammatory breast carcinoma10.0ESR1, PGR
39phyllode tumor10.0PGR, VIM
40angiosarcoma10.0ACTC1, VIM
41breast fibroadenoma10.0ESR1, PGR
42malignant peripheral nerve sheath tumor10.0VIM, ACTC1
43ovarian disease10.0ESR1, CYP19A1
44leydig cell tumor10.0LGALS1, CYP19A1
45teratoma10.0KRT7, ACTC1
46neurofibroma10.0VIM, ACTC1
47epithelioid leiomyosarcoma10.0ACTC1, VIM, DES
48pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
49osteoporosis, postmenopausal10.0ESR1, CYP19A1
50dermatofibrosarcoma protuberans10.0DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Symptoms for Benign Metastasizing Leiomyoma

About this section

Drugs & Therapeutics for Benign Metastasizing Leiomyoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Benign Metastasizing Leiomyoma

Drug clinical trials:

Search ClinicalTrials for Benign Metastasizing Leiomyoma

Search NIH Clinical Center for Benign Metastasizing Leiomyoma

Search CenterWatch for Benign Metastasizing Leiomyoma

Genetic Tests for Benign Metastasizing Leiomyoma

About this section

Anatomical Context for Benign Metastasizing Leiomyoma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

34
Lung, Uterus, Spinal cord, Ovary, Lymph node, Breast, Skeletal muscle

Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3BCL2, LGALS1, ESR1, PGR, CYP19A1
2MP:00053857.9DES, CYP19A1, PGR, ESR1, VIM, ACTC1
3MP:00053897.9CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
4MP:00053767.7DES, CYP19A1, PGR, ESR1, VIM, ACTC1
5MP:00053867.7DES, CYP19A1, PGR, ESR1, VIM, LGALS1
6MP:00053877.5CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
7MP:00107687.5DES, PGR, ESR1, VIM, LGALS1, ACTC1
8MP:00053697.4BCL2, DES, CYP19A1, PGR, ESR1, VIM
9MP:00053847.3CYP19A1, PGR, ESR1, VIM, ACTC1, BCL2

Publications for Benign Metastasizing Leiomyoma

About this section
Sources:
53PubMed
See all sources

Articles related to Benign Metastasizing Leiomyoma:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis. (24272622)
2014
2
Benign metastasizing leiomyoma of the lung: report of a case. (23117336)
2013
3
A rare pancreatic tumor in a 52-year-old Chinese woman. Pancreatic benign metastasizing leiomyoma. (23333466)
2013
4
Pulmonary benign metastasizing leiomyoma: report of three cases. (24139514)
2013
5
Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review. (23465706)
2013
6
Elevated 99mTc 3PRGD2 activity in benign metastasizing leiomyoma. (23334126)
2013
7
Benign metastasizing leiomyoma : Case report and review of the literature. (23903362)
2013
8
Multifocal osteolytic lesions within lumbar spine in a middle-aged Chinese woman: a benign metastasizing leiomyoma? (21857396)
2012
9
Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. (22632533)
2012
10
Favorable response to antigonadal therapy for a benign metastasizing leiomyoma. (22270431)
2012
11
Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. (23234399)
2012
12
Benign metastasizing leiomyoma of the lung. (21959195)
2012
13
FDG-PET/CT finding of benign metastasizing leiomyoma of the lung. (23986835)
2012
14
Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. (21811430)
2011
15
Serial spread of benign metastasizing leiomyoma to the thoracic spine. (21658956)
2011
16
Pulmonary and retroperitoneal benign metastasizing leiomyoma. (22384439)
2011
17
Benign metastasizing leiomyoma - case report and review of literature. (21835535)
2011
18
Benign metastasizing leiomyoma of external iliac vessels: an unusual case report. (20800337)
2011
19
Benign metastasizing leiomyoma identified using 18F-FDG PET/CT. (20435308)
2010
20
Pathogenesis of benign metastasizing leiomyoma: a review. (20214834)
2010
21
Benign metastasizing leiomyoma: report of two cases and literature review. (21163149)
2010
22
Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle. (20103256)
2010
23
A benign metastasizing leiomyoma involving a nodule in the pulmonary artery: case and literature review. (21077481)
2010
24
Benign metastasizing leiomyoma of the lung: PET findings. (19242303)
2009
25
A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole. (18523791)
2009
26
Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma? (19331193)
2009
27
Benign metastasizing leiomyoma: report of 2 cases and review of the literature. (19771765)
2009
28
Benign metastasizing leiomyoma of the lung: potential role of low-grade malignancy. (19330762)
2009
29
Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy. (18259767)
2008
30
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. (18382364)
2008
31
Benign metastasizing leiomyoma of the uterus. (17198463)
2007
32
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. (16357844)
2006
33
Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature. (16343217)
2005
34
Pulmonary benign metastasizing leiomyoma from the uterus in a postmenopausal woman: report of a case. (14714229)
2004
35
Benign metastasizing leiomyoma and lymphangioleiomyomatosis: sex-specific diseases? (15099894)
2004
36
Benign metastasizing leiomyoma to skull base and spine: a report of two cases. (12860509)
2003
37
Benign metastasizing leiomyoma causing spinal cord compression. (14670684)
2003
38
Benign metastasizing leiomyoma. (11972229)
2002
39
Benign metastasizing leiomyoma of the lung: a case report. (11155751)
2000
40
Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. (11037349)
2000
41
Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. (10506455)
1999
42
Pulmonary leiomyomatosis in women after hysterectomy for uterine myoma. Benign metastasizing leiomyoma? (10439097)
1999
43
Benign metastasizing leiomyoma in the lung. (9599398)
1998
44
Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. (8739468)
1996
45
Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. (21594362)
1996
46
Fine needle aspiration diagnosis of benign metastasizing leiomyoma of the lung. A case report. (8191830)
1994
47
Benign metastasizing leiomyoma. (3800475)
1987
48
Use of LHRH analogue to obtain reversible castration in a patient with benign metastasizing leiomyoma. (3085706)
1986
49
Benign metastasizing leiomyoma. (6703252)
1984
50
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. (7242600)
1981

Variations for Benign Metastasizing Leiomyoma

About this section

Expression for genes affiliated with Benign Metastasizing Leiomyoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Benign Metastasizing Leiomyoma

Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 61Thomson Reuters, 31KEGG, 54QIAGEN, 5Cell Signaling Technology
See all sources

Compounds for genes affiliated with Benign Metastasizing Leiomyoma

About this section
Sources:
46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1orcein469.8VIM, ACTC1, DES
2s 100469.8VIM, DES, ACTC1
3idoxifene469.7CYP19A1, PGR, ESR1
4estradiol benzoate469.6PGR, ESR1, CYP19A1
5nandrolone46 2510.6CYP19A1, PGR, ESR1
6goserelin46 30 1211.6ESR1, PGR, CYP19A1
7megestrol acetate469.6CYP19A1, ESR1, PGR
8leuprolide acetate469.6CYP19A1, PGR, ESR1
9exemestane46 52 62 1212.6ESR1, CYP19A1, PGR
10anastrozole46 52 1211.5PGR, CYP19A1, ESR1
11bisphenol a469.5CYP19A1, ESR1, PGR
12lapatinib46 52 1211.5PGR, CYP19A1, ESR1
13clomiphene citrate469.5CYP19A1, PGR, ESR1
14toremifene46 1210.5ESR1, PGR, CYP19A1
15tibolone469.4ESR1, CYP19A1, PGR
16danazol46 25 1211.4CYP19A1, ESR1, PGR
17fulvestrant46 52 30 1212.4ESR1, CYP19A1, PGR
18letrozole46 52 62 1212.3ESR1, CYP19A1, PGR
19levonorgestrel46 62 30 1212.3CYP19A1, PGR, ESR1
20procollagen469.3VIM, DES, LGALS1, ACTC1
21adriamycin469.2DES, PGR, VIM, BCL2
224-hydroxytamoxifen469.2ESR1, PGR, VIM, CYP19A1
23taxane469.2CYP19A1, BCL2, ESR1, PGR
24n-(4-hydroxyphenyl)retinamide469.1BCL2, VIM, ESR1, CYP19A1
25reticulin469.1VIM, ACTC1, KRT7, DES
26mucicarmine469.1KRT7, ACTC1, VIM, DES
27b 723469.0KRT7, ACTC1, VIM, DES
28hematoxylin469.0DES, KRT7, ACTC1, VIM
29docetaxel46 52 62 1212.0ESR1, CYP19A1, BCL2, PGR
30progestin469.0CYP19A1, PGR, ESR1, VIM, DES
31dihydrotestosterone46 30 25 1211.9CYP19A1, DES, PGR, VIM, ESR1
32flutamide46 62 1210.9PGR, CYP19A1, ESR1
33estradiol46 25 1210.9DES, CYP19A1, PGR, ESR1, VIM
34cyclophosphamide46 52 1210.8ESR1, CYP19A1, BCL2, PGR
35tamoxifen46 52 30 1211.7CYP19A1, ESR1, BCL2, VIM, PGR
36paclitaxel46 52 1210.7BCL2, VIM, ESR1, CYP19A1, PGR
37genistein46 30 62 3 25 1213.7CYP19A1, PGR, VIM, BCL2, ESR1
38formaldehyde46 259.7DES, CYP19A1, VIM, ACTC1, KRT7
39doxorubicin46 52 1210.5BCL2, DES, VIM, CYP19A1, ESR1, PGR
40dexamethasone46 52 30 1211.4BCL2, CYP19A1, PGR, ACTC1, VIM, LGALS1
41methotrexate52 46 1210.4KRT7, VIM, ESR1, PGR, CYP19A1
42cycloheximide468.4PGR, ESR1, BCL2, VIM, CYP19A1
435-aza-2deoxycytidine468.3ESR1, VIM, KRT7, PGR
44retinoid467.8PGR, ESR1, VIM, KRT7, BCL2, LGALS1
45testosterone46 62 25 1210.8VIM, ACTC1, KRT7, ESR1, PGR, CYP19A1
46vegf467.7KRT7, ESR1, DES, BCL2, PGR, VIM
47progesterone46 30 62 25 1211.4KRT7, VIM, BCL2, DES, CYP19A1, PGR
48retinoic acid46 258.4PGR, ESR1, KRT7, VIM, ACTC1, CYP19A1
49paraffin467.2DES, VIM, KRT7, PGR, BCL2, ACTC1
50estrogen466.9DES, CYP19A1, PGR, ESR1, VIM, LGALS1

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT7, VIM, DES

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.6ESR1, CYP19A1
2muscle filament slidingGO:0300499.5ACTC1, VIM, DES
3negative regulation of neuron projection developmentGO:0109779.2LGALS1, VIM
4response to drugGO:0424939.2BCL2, ACTC1, LGALS1
5apoptotic processGO:0069158.7VIM, LGALS1, ACTC1, BCL2

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.6ESR1, PGR
2steroid bindingGO:0054969.5PGR, ESR1
3glycoprotein bindingGO:0019489.2LGALS1, VIM
4identical protein bindingGO:0428028.8BCL2, VIM, ESR1, DES

Products for genes affiliated with Benign Metastasizing Leiomyoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Benign Metastasizing Leiomyoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet