MCID: BNG041
MIFTS: 45

Benign Metastasizing Leiomyoma malady

Rare diseases, Cancer diseases categories
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Summaries for Benign Metastasizing Leiomyoma

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MalaCards based summary: Benign Metastasizing Leiomyoma, also known as benign metastasising leiomyoma, is related to leiomyomatosis and lymphangioleiomyomatosis. An important gene associated with Benign Metastasizing Leiomyoma is DES (desmin), and among its related pathways are Aurora B signaling and Ovarian Infertility Genes. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, uterus and bone, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Benign Metastasizing Leiomyoma

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Benign Metastasizing Leiomyoma, Aliases & Descriptions:

Name: Benign Metastasizing Leiomyoma 42
 
Benign Metastasising Leiomyoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Benign Metastasizing Leiomyoma

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Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyomatosis31.2PGR, ESR1
2lymphangioleiomyomatosis30.9PGR, ESR1, DES
3leiomyoma30.8CYP19A1, PGR, ESR1, VIM, LGALS1, DES
4myoma30.4ESR1, PGR, CYP19A1
5sarcoma30.2DES, VIM, LGALS1, ACTC1
6lung cancer30.1KRT7, BCL2, LGALS1
7infantile myofibromatosis10.5DES
8metanephric adenoma10.5KRT7
9fasciitis10.5ACTC1
10cystadenoma10.5KRT7
11pseudomyxoma peritonei10.5KRT7
12cerebral meningioma10.4PGR
13adenomatoid tumor10.4VIM
14intravenous leiomyomatosis10.4
15desmoid tumor10.4DES, ACTC1
16cutaneous fibrous histiocytoma10.4DES, ACTC1
17embryonal rhabdomyosarcoma10.3DES, ACTC1
18sertoli-leydig cell tumor10.3PGR, KRT7
19mucoepidermoid carcinoma10.3ACTC1, KRT7
20mesenchymal chondrosarcoma10.3VIM, DES
21secretory meningioma10.3VIM, KRT7
22ductal carcinoma in situ10.2PGR, ESR1
23estrogen excess10.2CYP19A1, PGR
24alveolar soft part sarcoma10.2DES, VIM
25meningioma10.2PGR, ESR1
26cribriform carcinoma10.2PGR, ESR1
27progesterone resistance10.2PGR, ESR1
28bilateral breast cancer10.2PGR, ESR1
29adenosquamous carcinoma10.2PGR, KRT7
30granular cell tumor10.2DES, VIM
31mediastinitis10.2
32pancreatitis10.2
33pneumothorax10.2
34spontaneous pneumothorax10.2
35male breast cancer10.2PGR, ESR1
36li-fraumeni syndrome10.2PGR, ESR1
37myoepithelioma10.2VIM, ACTC1
38endocrine gland cancer10.2CYP19A1, ESR1
39epithelioid sarcoma10.2VIM, KRT7
40uterine fibroid10.2ESR1, PGR
41inflammatory breast carcinoma10.2PGR, ESR1
42phyllode tumor10.2VIM, PGR
43breast ductal carcinoma10.2PGR, ESR1
44angiosarcoma10.2ACTC1, VIM
45breast fibroadenoma10.2ESR1, PGR
46malignant peripheral nerve sheath tumor10.2ACTC1, VIM
47ovarian disease10.2CYP19A1, ESR1
48leydig cell tumor10.2LGALS1, CYP19A1
49teratoma10.2KRT7, ACTC1
50neurofibroma10.1ACTC1, VIM

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Symptoms for Benign Metastasizing Leiomyoma

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Drugs & Therapeutics for Benign Metastasizing Leiomyoma

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Drug clinical trials:

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Search NIH Clinical Center for Benign Metastasizing Leiomyoma

Genetic Tests for Benign Metastasizing Leiomyoma

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Anatomical Context for Benign Metastasizing Leiomyoma

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MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

32
Lung, Uterus, Bone, Lymph node, Spinal cord, Breast, Ovary, Skeletal muscle

Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

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MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3BCL2, LGALS1, ESR1, PGR, CYP19A1
2MP:00053857.9DES, CYP19A1, PGR, ESR1, VIM, ACTC1
3MP:00053897.9CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
4MP:00053767.7DES, CYP19A1, PGR, ESR1, VIM, ACTC1
5MP:00053867.7DES, CYP19A1, PGR, ESR1, VIM, LGALS1
6MP:00053877.5CYP19A1, PGR, ESR1, VIM, LGALS1, BCL2
7MP:00107687.5DES, PGR, ESR1, VIM, LGALS1, ACTC1
8MP:00053697.4BCL2, DES, CYP19A1, PGR, ESR1, VIM
9MP:00053847.3CYP19A1, PGR, ESR1, VIM, ACTC1, BCL2

Publications for Benign Metastasizing Leiomyoma

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Articles related to Benign Metastasizing Leiomyoma:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Incidental benign metastasizing leiomyoma in a patient with bone sarcoma: a case report. (25221682)
2014
2
Pulmonary benign metastasizing leiomyoma: a case report and literature review. (24977035)
2014
3
Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis. (24272622)
2014
4
Benign metastasizing leiomyoma: a rare type of lung metastases-two case reports and review of the literature. (24716049)
2014
5
Benign metastasizing leiomyoma of the lung: report of a case. (23117336)
2013
6
Benign metastasizing leiomyoma of the lung with spontaneous pneumothorax. (25360407)
2013
7
A rare pancreatic tumor in a 52-year-old Chinese woman. Pancreatic benign metastasizing leiomyoma. (23333466)
2013
8
Pulmonary benign metastasizing leiomyoma: report of three cases. (24139514)
2013
9
Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review. (23465706)
2013
10
Elevated 99mTc 3PRGD2 activity in benign metastasizing leiomyoma. (23334126)
2013
11
Benign metastasizing leiomyoma : Case report and review of the literature. (23903362)
2013
12
Multifocal osteolytic lesions within lumbar spine in a middle-aged Chinese woman: a benign metastasizing leiomyoma? (21857396)
2012
13
Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. (22632533)
2012
14
Favorable response to antigonadal therapy for a benign metastasizing leiomyoma. (22270431)
2012
15
Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. (23234399)
2012
16
Benign metastasizing leiomyoma of the lung. (21959195)
2012
17
Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. (21811430)
2011
18
Serial spread of benign metastasizing leiomyoma to the thoracic spine. (21658956)
2011
19
Pulmonary and retroperitoneal benign metastasizing leiomyoma. (22384439)
2011
20
Benign metastasizing leiomyoma - case report and review of literature. (21835535)
2011
21
Benign metastasizing leiomyoma of external iliac vessels: an unusual case report. (20800337)
2011
22
Benign metastasizing leiomyoma identified using 18F-FDG PET/CT. (20435308)
2010
23
Pathogenesis of benign metastasizing leiomyoma: a review. (20214834)
2010
24
Benign metastasizing leiomyoma: report of two cases and literature review. (21163149)
2010
25
Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle. (20103256)
2010
26
A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole. (18523791)
2009
27
Intravenous leiomyomatosis of the uterus with pulmonary metastases or a case with benign metastasizing leiomyoma? (19331193)
2009
28
Benign metastasizing leiomyoma: report of 2 cases and review of the literature. (19771765)
2009
29
Benign metastasizing leiomyoma of the lung: potential role of low-grade malignancy. (19330762)
2009
30
Recurrent benign metastasizing leiomyoma after hysterectomy and bilateral salpingo-oophorectomy. (18259767)
2008
31
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. (18382364)
2008
32
Benign metastasizing leiomyoma of the uterus. (17198463)
2007
33
Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. (16357844)
2006
34
Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature. (16343217)
2005
35
Pulmonary benign metastasizing leiomyoma from the uterus in a postmenopausal woman: report of a case. (14714229)
2004
36
Benign metastasizing leiomyoma to skull base and spine: a report of two cases. (12860509)
2003
37
Benign metastasizing leiomyoma causing spinal cord compression. (14670684)
2003
38
Benign metastasizing leiomyoma in the lung: a case report. (12440822)
2002
39
Benign metastasizing leiomyoma. (11972229)
2002
40
Benign metastasizing leiomyoma of the lung: a case report. (11155751)
2000
41
Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. (11037349)
2000
42
Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. (10506455)
1999
43
Pulmonary leiomyomatosis in women after hysterectomy for uterine myoma. Benign metastasizing leiomyoma? (10439097)
1999
44
Benign metastasizing leiomyoma in the lung. (9599398)
1998
45
Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. (8739468)
1996
46
Efficacy of antiestrogen treatment in a benign metastasizing leiomyoma with paraneoplastic estradiol production. (21594362)
1996
47
Fine needle aspiration diagnosis of benign metastasizing leiomyoma of the lung. A case report. (8191830)
1994
48
Use of LHRH analogue to obtain reversible castration in a patient with benign metastasizing leiomyoma. (3085706)
1986
49
Benign metastasizing leiomyoma. (6703252)
1984
50
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. (7242600)
1981

Variations for Benign Metastasizing Leiomyoma

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Expression for genes affiliated with Benign Metastasizing Leiomyoma

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Expression patterns in normal tissues for genes affiliated with Benign Metastasizing Leiomyoma

Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

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Compounds for genes affiliated with Benign Metastasizing Leiomyoma

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Compounds related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1orcein449.8VIM, ACTC1, DES
2s 100449.8VIM, DES, ACTC1
3idoxifene449.7CYP19A1, PGR, ESR1
4estradiol benzoate449.6PGR, ESR1, CYP19A1
5nandrolone44 2410.6CYP19A1, PGR, ESR1
6goserelin44 28 1111.6ESR1, PGR, CYP19A1
7megestrol acetate449.6CYP19A1, ESR1, PGR
8leuprolide acetate449.6CYP19A1, PGR, ESR1
9exemestane44 50 61 1112.6ESR1, CYP19A1, PGR
10anastrozole44 50 1111.5PGR, CYP19A1, ESR1
11bisphenol a449.5CYP19A1, ESR1, PGR
12lapatinib44 50 1111.5PGR, CYP19A1, ESR1
13clomiphene citrate449.5CYP19A1, PGR, ESR1
14toremifene44 1110.5ESR1, PGR, CYP19A1
15tibolone449.4ESR1, CYP19A1, PGR
16danazol44 24 1111.4CYP19A1, ESR1, PGR
17fulvestrant44 50 28 1112.4ESR1, CYP19A1, PGR
18letrozole44 50 61 1112.3ESR1, CYP19A1, PGR
19levonorgestrel44 61 28 1112.3CYP19A1, PGR, ESR1
20procollagen449.3VIM, DES, LGALS1, ACTC1
21adriamycin449.2DES, PGR, VIM, BCL2
224-hydroxytamoxifen449.2ESR1, PGR, VIM, CYP19A1
23taxane449.2CYP19A1, BCL2, ESR1, PGR
24n-(4-hydroxyphenyl)retinamide449.1BCL2, VIM, ESR1, CYP19A1
25reticulin449.1VIM, ACTC1, KRT7, DES
26mucicarmine449.1KRT7, ACTC1, VIM, DES
27b 723449.0KRT7, ACTC1, VIM, DES
28hematoxylin449.0DES, KRT7, ACTC1, VIM
29docetaxel44 50 61 1112.0ESR1, CYP19A1, BCL2, PGR
30progestin449.0CYP19A1, PGR, ESR1, VIM, DES
31dihydrotestosterone44 28 24 1111.9CYP19A1, DES, PGR, VIM, ESR1
32flutamide44 61 1110.9PGR, CYP19A1, ESR1
33estradiol44 24 1110.9DES, CYP19A1, PGR, ESR1, VIM
34cyclophosphamide44 50 1110.8ESR1, CYP19A1, BCL2, PGR
35tamoxifen44 50 28 1111.7CYP19A1, ESR1, BCL2, VIM, PGR
36paclitaxel44 50 1110.7BCL2, VIM, ESR1, CYP19A1, PGR
37genistein44 28 61 2 24 1113.7CYP19A1, PGR, VIM, BCL2, ESR1
38formaldehyde44 249.7DES, CYP19A1, VIM, ACTC1, KRT7
39doxorubicin44 50 1110.5BCL2, DES, VIM, CYP19A1, ESR1, PGR
40dexamethasone44 50 28 1111.4BCL2, CYP19A1, PGR, ACTC1, VIM, LGALS1
41methotrexate50 44 1110.4KRT7, VIM, ESR1, PGR, CYP19A1
42cycloheximide448.4PGR, ESR1, BCL2, VIM, CYP19A1
435-aza-2deoxycytidine448.3ESR1, VIM, KRT7, PGR
44retinoid447.8PGR, ESR1, VIM, KRT7, BCL2, LGALS1
45testosterone44 61 24 1110.8VIM, ACTC1, KRT7, ESR1, PGR, CYP19A1
46vegf447.7KRT7, ESR1, DES, BCL2, PGR, VIM
47progesterone44 28 61 24 1111.4KRT7, VIM, BCL2, DES, CYP19A1, PGR
48retinoic acid44 248.4PGR, ESR1, KRT7, VIM, ACTC1, CYP19A1
49paraffin447.2DES, VIM, KRT7, PGR, BCL2, ACTC1
50estrogen446.9DES, CYP19A1, PGR, ESR1, VIM, LGALS1

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

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Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.9KRT7, VIM, DES

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.6ESR1, CYP19A1
2muscle filament slidingGO:0300499.5ACTC1, VIM, DES
3negative regulation of neuron projection developmentGO:0109779.2LGALS1, VIM
4response to drugGO:0424939.2BCL2, ACTC1, LGALS1
5apoptotic processGO:0069158.7VIM, LGALS1, ACTC1, BCL2

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.6ESR1, PGR
2steroid bindingGO:0054969.5PGR, ESR1
3glycoprotein bindingGO:0019489.2LGALS1, VIM
4identical protein bindingGO:0428028.8BCL2, VIM, ESR1, DES

Products for genes affiliated with Benign Metastasizing Leiomyoma

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Sources for Benign Metastasizing Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet