MCID: BNG041
MIFTS: 31

Benign Metastasizing Leiomyoma malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Benign Metastasizing Leiomyoma

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Aliases & Descriptions for Benign Metastasizing Leiomyoma:

Name: Benign Metastasizing Leiomyoma 45
 
Benign Metastasizing Leiomyoma of Uterus 65

Classifications:



External Ids:

UMLS65 C0346201

Summaries for Benign Metastasizing Leiomyoma

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MalaCards based summary: Benign Metastasizing Leiomyoma, also known as benign metastasizing leiomyoma of uterus, is related to leiomyoma and melanoma. An important gene associated with Benign Metastasizing Leiomyoma is DES (Desmin), and among its related pathways are Ovarian Infertility Genes and Aurora B signaling. Affiliated tissues include uterus, breast and kidney, and related mouse phenotypes are cardiovascular system and cellular.

Related Diseases for Benign Metastasizing Leiomyoma

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Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyoma30.4CYP19A1, PGR
2melanoma30.2ACTC1, DES, VIM
3fibromatosis multiple non ossifying10.4DES, PGR
4pulmonary venous return anomaly10.4ACTC1, DES
5retroperitoneal sarcoma10.4CYP19A1, PGR
6sciatic neuropathy10.4CYP19A1, PGR
7deep leiomyoma10.4ACTC1, PGR
8suppurative thyroiditis10.4CYP19A1, PGR
9uveal diseases10.4CYP19A1, DES
10benign deep fibrous histiocytoma10.4ACTC1, DES
11gingival hypertrophy10.3DES, VIM
12prostatic cyst10.3CYP19A1, PGR
13spindle cell variant squamous cell breast carcinoma10.3DES, VIM
14proliferative fasciitis10.3ACTC1, DES
15grayson-wilbrandt corneal dystrophy10.3ACTC1, PGR
16vulvar angiokeratoma10.3DES, VIM
17breast papillomatosis10.3PGR, VIM
18rectum mucinous adenocarcinoma10.3PGR, VIM
19progesterone-receptor negative breast cancer10.3CYP19A1, PGR
20uterine corpus adenocarcinofibroma10.3DES, VIM
21autosomal dominant charcot-marie-tooth disease type 2a210.3ACTC1, DES
22papillary carcinoma10.3PGR, VIM
23breast leiomyoma10.3CYP19A1, PGR
24transverse vaginal septum10.3ACTC1, DES
25absence of fingerprints congenital milia10.3ACTC1, VIM
2646xy sex reversal 510.3DES, VIM
27familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement10.3ACTC1, VIM
28renal tubular acidosis, distal, autosomal recessive10.3DES, VIM
29hyperuricemia10.3CYP19A1, PGR
30uterine corpus adenosarcoma10.3BCL2, PGR
31ovarian mucinous cystadenocarcinoma10.3ACTC1, VIM
32cellular schwannoma10.3DES, VIM
33desmoplastic infantile astrocytoma10.2ACTC1, DES
34hypothyroidism due to deficient transcription factors involved in pituitary development or function10.2ACTC1, VIM
35estrogen-receptor negative breast cancer10.2CYP19A1, PGR
36leptospirosis10.2CYP19A1, PGR
37childhood choriocarcinoma of the ovary10.2KRT7, PGR
38spondylitis10.2KRT7, PGR
39cervical adenoid cystic carcinoma10.2BCL2, PGR
40vulvar alveolar soft part sarcoma10.2KRT7, PGR
41pancreatic cystadenoma10.2KRT7, PGR
42follicular basal cell carcinoma10.2KRT7, PGR
43hepatitis10.2
44dermatitis10.2
45cavernous sinus thrombosis10.2
46leydig cell tumor10.2CYP19A1, PGR
47pancreatic invasive mucinous cystadenocarcinoma10.2KRT7, PGR
48estrogen-receptor positive breast cancer10.2CYP19A1, PGR
49uterine carcinosarcoma10.2KRT7, PGR
50thymus lipoma10.2ACTC1, DES, PGR

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Symptoms for Benign Metastasizing Leiomyoma

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Drugs & Therapeutics for Benign Metastasizing Leiomyoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Establishment of Fibroid Tissue BankCompletedNCT00710346

Search NIH Clinical Center for Benign Metastasizing Leiomyoma

Genetic Tests for Benign Metastasizing Leiomyoma

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Anatomical Context for Benign Metastasizing Leiomyoma

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MalaCards organs/tissues related to Benign Metastasizing Leiomyoma:

33
Uterus, Breast, Kidney, Lung, Pancreas, Spleen, T cells

Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

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MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.0ACTC1, BCL2, CYP19A1, DES, PGR, VIM
2MP:00053847.5ACTC1, BCL2, CYP19A1, DES, KRT7, PGR
3MP:00053696.9ACTC1, BCL2, CYP19A1, DES, LGALS1, PGR
4MP:00053766.5ACTC1, BCL2, CYP19A1, DES, KRT7, LGALS1

Publications for Benign Metastasizing Leiomyoma

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Articles related to Benign Metastasizing Leiomyoma:

(show top 50)    (show all 98)
idTitleAuthorsYear
1
An analysis of different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia: a single-centre experience. (25727927)
2015
2
Application of Ga(68) -DOTA-exendin-4 PET/CT to localise an occult insulinoma. (26562613)
2015
3
Torsin 1A and the pathomechanism of torsion dystonia type 1]. (26281352)
2015
4
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. (24736845)
2014
5
Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. (24999486)
2014
6
Differentiation of Crohn's disease from intestinal tuberculosis by clinical and CT enterographic models. (24694791)
2014
7
Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome. (25365257)
2014
8
Induction of T helper 2 responses against human apolipoprotein B100 does not affect atherosclerosis in ApoE-/- mice. (24866382)
2014
9
Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome. (24782504)
2014
10
Allele-specific characterization of alanine: glyoxylate aminotransferase variants associated with primary hyperoxaluria. (24718375)
2014
11
Recurrence and outcome after complete tumour removal and hyperthermic intraperitoneal chemotherapy in 512 patients with pseudomyxoma peritonei from perforated appendiceal mucinous tumours. (25216980)
2014
12
Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. (23606532)
2013
13
Association between reduced kidney function and clinical outcomes after ischaemic stroke with atrial fibrillation. (24237478)
2013
14
A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. (23983255)
2013
15
Long-term follow-up of bilateral botulinum toxin injections versus bilateral recessions of the medial rectus muscles for treatment of infantile esotropia. (22681945)
2012
16
SOX9 regulates endocrine cell differentiation during human fetal pancreas development. (21983268)
2012
17
Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces. (22396152)
2012
18
An unusual cause of dysphagia: pericardial effusion after implantable cardioverter-defibrillator placement. (22137154)
2012
19
Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs. (21605442)
2011
20
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells. (20100890)
2010
21
Re: one-stage management of ankylosis of the temporomandibular joint with a custom-made total joint replacement system. (20004048)
2010
22
The nature of hyperthermia in neuroleptic malignant syndrome and the use of bromocriptine. (20361363)
2010
23
Recent trends in the management of antiphospholipid syndrome (Hughes syndrome). (20200695)
2010
24
Lyme disease as a cause of acropapular dermatitis of childhood. (19840337)
2009
25
Elovl6: a new player in fatty acid metabolism and insulin sensitivity. (19259639)
2009
26
The genetics of Crohn's disease. (19453248)
2009
27
Signet ring cell plasmacytoma: a rare morphological variant. (18604751)
2008
28
Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons. (17986231)
2008
29
Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults. (17684217)
2007
30
betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG. (17283186)
2007
31
Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau. (17526496)
2007
32
Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. (18038872)
2007
33
Prognostic significance of homozygous deletions and multiple duplications at the CDKN2A (p16INK4a)/ARF (p14ARF) locus in urinary bladder cancer. (17060081)
2006
34
Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)--induced oxidative damage in Leydig cells. (16298753)
2005
35
Primary desmoplastic small round cell tumor of bone: report of a case with cytogenetic confirmation. (15642398)
2005
36
Quantification of yessotoxin using the fluorescence polarization technique and study of the adequate extraction procedure. (16061192)
2005
37
Sex steroid-dependent angiogenesis in uterine endometrial cancers. (15860258)
2005
38
Just how happy is the happy puppet? An emotion signaling and kinship theory perspective on the behavioral phenotype of children with Angelman syndrome. (15288352)
2004
39
Mechanosensitive induction of apoptosis in fibroblasts is regulated by thrombospondin-1 and integrin associated protein (CD47). (12370491)
2002
40
Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. (10964924)
2000
41
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (10548550)
1999
42
Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. (9790530)
1998
43
Idiopathic cervical dystonia: Report of discordance in a pair of monozygotic twins. (18591071)
1997
44
Plasmapheresis maintained renal function in an allograft with recurrent membranoproliferative glomerulonephritis type I. (7503148)
1995
45
Imaging techniques for breast disease. (7842561)
1994
46
Reduced expression of apoptosis-related antigens in thymuses from patients with myasthenia gravis. (7516912)
1994
47
The action of ticlopidine on human platelets. Studies on aggregation, secretion, calcium mobilization and membrane glycoproteins. (2274920)
1990
48
Surgical treatment of idiopathic hyperinsulinemic hypoglycemia in children. First successful subtotal pancreatectomy with preservation of spleen reported by Evarts A. Graham (1934). (6387297)
1984
49
Traumatic hemopericardium and chronic constrictive pericarditis. (849027)
1977
50
Occult endemic encephalitozoonosis of the central nervous system of mice (Swiss-Bagg-O'Grady strain). (13956571)
1962

Variations for Benign Metastasizing Leiomyoma

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Expression for genes affiliated with Benign Metastasizing Leiomyoma

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Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

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Pathways related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8CYP19A1, PGR
2
Show member pathways
9.7DES, VIM
39.3ACTC1, DES, VIM
4
Show member pathways
9.1DES, KRT7, VIM
59.0BCL2, MIR221, VIM

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

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Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:00451119.7DES, VIM

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.5ACTC1, VIM
2regulation of apoptotic processGO:00429819.1BCL2, LGALS1

Sources for Benign Metastasizing Leiomyoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet