MCID: BNG041
MIFTS: 30

Benign Metastasizing Leiomyoma malady

Cancer diseases category

Summaries for Benign Metastasizing Leiomyoma

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32MalaCards
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MalaCards: Benign Metastasizing Leiomyoma is related to leiomyoma and leiomyomatosis. An important gene associated with Benign Metastasizing Leiomyoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Ovarian Infertility Genes and Estrogen biosynthesis. The compounds orcein and s 100 have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and homeostasis/metabolism.

Aliases & Classifications for Benign Metastasizing Leiomyoma

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42NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

benign metastasizing leiomyoma 42


Related Diseases for Benign Metastasizing Leiomyoma

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17GeneCards, 18GeneDecks
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Diseases related to Benign Metastasizing Leiomyoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyoma31.6ESR1, LGALS1, ACTC1, PGR, CYP19A1, DES
2leiomyomatosis30.8PGR, ESR1
3lymphangioleiomyomatosis30.6ESR1, PGR, DES
4lung cancer30.2BCL2, KRT7
5myoma30.2CYP19A1, PGR, ESR1
6lung leiomyoma10.8
7intravenous leiomyomatosis10.4
8breast leiomyoma10.2
9mediastinitis10.2
10pancreatitis10.2
11pulmonary embolism10.2
12papilloma10.0ACTC1
13fasciitis10.0ACTC1
14hemangioma10.0ACTC1
15seminoma10.0LGALS1
16thyroid cancer10.0LGALS1
17infantile myofibromatosis10.0DES
18cystadenoma10.0KRT7
19rheumatoid arthritis10.0LGALS1
20lipoma10.0DES
21hypertrophic cardiomyopathy10.0ACTC1
22synovial sarcoma10.0KRT7
23metanephric adenoma10.0KRT7
24mixed cell type cancer10.0KRT7
25craniopharyngioma10.0LGALS1
26thymus cancer10.0KRT7
27atherosclerosis10.0LGALS1
28adenomatoid tumor10.0VIM
29tuberous sclerosis10.0VIM
30cerebral meningioma10.0PGR
31pseudomyxoma peritonei10.0KRT7
32oxyphilic adenoma10.0KRT7
33astrocytoma10.0VIM
34myopathy10.0DES
35desmoid tumor10.0ACTC1, DES
36teratoma10.0KRT7, ACTC1
37cryptorchidism10.0CYP19A1
38perineurioma10.0VIM
39aromatase deficiency10.0CYP19A1
40cervical cancer10.0BCL2
41sertoli-leydig cell tumor10.0PGR, KRT7
42cutaneous fibrous histiocytoma10.0DES, ACTC1
43medulloblastoma10.0ACTC1, DES
44angiosarcoma10.0ACTC1, VIM
45myoepithelioma10.0VIM, ACTC1
46epidermolysis bullosa simplex10.0DES
47stomach cancer10.0BCL2
48osteosarcoma10.0ESR1, LGALS1
49chondrosarcoma10.0VIM, DES
50embryonal rhabdomyosarcoma10.0ACTC1, DES

Graphical network of the top 20 diseases related to Benign Metastasizing Leiomyoma:



Diseases related to benign metastasizing leiomyoma

Clinical Features for Benign Metastasizing Leiomyoma

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Drugs & Therapeutics for Benign Metastasizing Leiomyoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Benign Metastasizing Leiomyoma

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Genetic Tests for Benign Metastasizing Leiomyoma

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Anatomical Context for Benign Metastasizing Leiomyoma

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Animal Models for Benign Metastasizing Leiomyoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Benign Metastasizing Leiomyoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.0BCL2
2MP:00053768.7DES, PGR, ACTC1, ESR1
3MP:00053698.5ESR1, LGALS1, ACTC1, CYP19A1
4MP:00053857.8VIM, DES, CYP19A1, PGR, ACTC1, ESR1
5MP:00053867.7ESR1, LGALS1, PGR, CYP19A1, DES, VIM
6MP:00053847.4VIM, CYP19A1, PGR, KRT7, ACTC1, ESR1

Publications for Benign Metastasizing Leiomyoma

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Genetic Variations for Benign Metastasizing Leiomyoma

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Expression for genes affiliated with Benign Metastasizing Leiomyoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Metastasizing Leiomyoma

Search GEO for disease gene expression data for Benign Metastasizing Leiomyoma.

Pathways for genes affiliated with Benign Metastasizing Leiomyoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PGR, CYP19A1
2
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9.5ESR1, CYP19A1
3
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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9.5BCL2, ESR1
49.5BCL2, ESR1
5
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9.5ACTC1, DES, VIM
69.1CYP19A1, ESR1, BCL2
79.0VIM, DES, KRT7, ACTC1

Compounds for genes affiliated with Benign Metastasizing Leiomyoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1orcein449.9ACTC1, DES, VIM
2s 100449.9VIM, DES, ACTC1
3idoxifene449.6CYP19A1, PGR, ESR1
4Chlorotrianisene119.6CYP19A1, ESR1
5Ethynodiol Diacetate119.6ESR1, PGR
6nandrolone44 2410.6PGR, CYP19A1, ESR1
7estradiol benzoate449.6PGR, ESR1, CYP19A1
8megestrol acetate449.6ESR1, PGR, CYP19A1
9anastrozole44 1110.6PGR, CYP19A1, ESR1
10leuprolide acetate449.6PGR, CYP19A1, ESR1
11dexamethasone44 49 28 1112.5BCL2, LGALS1
12exemestane49 44 59 1112.5CYP19A1, ESR1, PGR
13bisphenol a449.5ESR1, CYP19A1, PGR
14lapatinib44 49 1111.5CYP19A1, PGR, ESR1
15clomiphene citrate449.5ESR1, PGR, CYP19A1
16toremifene44 1110.5PGR, CYP19A1, ESR1
17ici 164384449.5PGR, ESR1
18tibolone449.5ESR1, CYP19A1, PGR
19fulvestrant44 49 28 1112.5CYP19A1, ESR1, PGR
20danazol44 11 2411.4CYP19A1, ESR1, PGR
21reticulin449.4ACTC1, VIM, DES, KRT7
22mucicarmine449.4KRT7, DES, VIM, ACTC1
23letrozole44 49 59 1112.4ESR1, CYP19A1, PGR
24b 723449.4ACTC1, VIM, DES, KRT7
25levonorgestrel44 59 28 1112.4CYP19A1, ESR1, PGR
26hematoxylin449.4ACTC1, KRT7, VIM, DES
27flutamide44 59 1111.3CYP19A1, PGR, ESR1
28adriamycin449.3BCL2, PGR, VIM, DES
29nolvadex449.2ESR1, CYP19A1
304-hydroxytamoxifen449.2VIM, CYP19A1, ESR1, PGR
31taxane449.2BCL2, PGR, CYP19A1, ESR1
32n-(4-hydroxyphenyl)retinamide449.1VIM, BCL2, CYP19A1, ESR1
33paclitaxel44 49 1111.1CYP19A1, PGR, BCL2, ESR1
34docetaxel44 49 59 1112.0ESR1, BCL2, CYP19A1, PGR
35formaldehyde44 2410.0CYP19A1, DES, KRT7, ACTC1, VIM
36progestin448.9VIM, ESR1, PGR, CYP19A1, DES
37dihydrotestosterone44 28 11 2411.9ESR1, VIM, DES, CYP19A1, PGR
38cyclophosphamide44 49 1110.9CYP19A1, PGR, BCL2, ESR1
39estradiol44 11 2410.8VIM, PGR, ESR1, DES, CYP19A1
40tamoxifen44 49 28 1111.7CYP19A1, ESR1, VIM, BCL2, PGR
415-aza-2deoxycytidine448.7KRT7, PGR, VIM, ESR1
42methotrexate44 49 1110.7VIM, CYP19A1, PGR, KRT7, ESR1
43genistein44 28 59 2 11 2413.6VIM, PGR, ESR1, BCL2, CYP19A1
44doxorubicin44 49 1110.5DES, VIM, BCL2, ESR1, PGR, CYP19A1
45testosterone44 59 11 2411.1VIM, KRT7, ESR1, ACTC1, CYP19A1, PGR
46vegf448.1ESR1, VIM, DES, KRT7, ACTC1, BCL2
47retinoid447.9VIM, BCL2, LGALS1, PGR, KRT7, ESR1
48progesterone44 59 28 11 2411.7PGR, KRT7, ESR1, BCL2, ACTC1, CYP19A1
49retinoic acid44 248.7DES, PGR, KRT7, CYP19A1, ACTC1, VIM
50paraffin447.3KRT7, BCL2, PGR, VIM, DES, ESR1

GO Terms for genes affiliated with Benign Metastasizing Leiomyoma

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16Gene Ontology
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Cellular components related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3KRT7, DES, VIM

Biological processes related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5ACTC1, DES, VIM
2androgen metabolic processGO:0082099.4ESR1, CYP19A1
3negative regulation of neuron projection developmentGO:0109779.0VIM, LGALS1
4apoptotic processGO:0069158.5BCL2, LGALS1, ACTC1, VIM

Molecular functions related to Benign Metastasizing Leiomyoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.6ESR1, PGR
2identical protein bindingGO:0428028.5BCL2, ESR1, DES, VIM

Products for genes affiliated with Benign Metastasizing Leiomyoma

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  • Antibodies
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Sources for Benign Metastasizing Leiomyoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet