MCID: BNG016
MIFTS: 40

Benign Migratory Glossitis malady

Gastrointestinal category

Summaries for Benign Migratory Glossitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Geographic tongue is a condition that causes lesions on the tongue that resemble psoriasis of the skin. the lesions may also occasionally occur in the mucosa of the mouth and labia; this condition is called areata migrans. the lesions typically disappear from one area and move to another. last updated: 7/9/2013

MalaCards: Benign Migratory Glossitis, also known as geographic tongue, is related to lyme disease and acrodermatitis. An important gene associated with Benign Migratory Glossitis is IL1B (interleukin 1, beta), and among its related pathways are Legionellosis and Tuberculosis. The compounds troglitazone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include skin and tongue.

Wikipedia:64 Geographic tongue (also known as benign migratory glossitis,BMG, erythema migrans,erythema migrans... more...

Description from OMIM:47 137400

Aliases & Classifications for Benign Migratory Glossitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 47OMIM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

benign migratory glossitis 8 43
geographic tongue 8 43
erythema migrans 43 61
glossitis areata exfoliativa 8
glossitis, benign migratory 61
ectopic geographic tongue 43
premature cardiac complex 61
pityriasis linguae 8


External Ids:

Disease Ontology8 DOID:1455
ICD9CM27 529.1
MeSH35 D005929
OMIM47 137400
NCIt40 C84588
ICD1025 K14.1

Related Diseases for Benign Migratory Glossitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Benign Migratory Glossitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1lyme disease10.6
2acrodermatitis10.6
3fissured tongue10.4
4lichen planus10.3
5median rhomboid glossitis10.3
6bronchitis10.3
7hairy tongue10.2
8stomatitis10.2
9aseptic meningitis10.1
10ectopia pupillae10.1
11pituitary stalk interruption syndrome10.1
12cushing syndrome due to ectopic acth secretion10.1
13melkersson-rosenthal syndrome10.1
14uveitis10.0TNF
15ankylosing spondylitis10.0TNF
16vasculitis10.0TNF
17encephalomyelitis10.0TNF
18degenerative disc disease10.0IL1B
19bacterial vaginosis10.0IL1B
20gingival overgrowth10.0IL1B
21mastitis10.0IL1B
22toxic encephalopathy10.0IL1B
23otitis media10.0IL1B
24gastritis10.0IL1B
25gout10.0IL1B
26malaria10.0TNF
27encephalitis10.0IL1B
28pulmonary fibrosis10.0IL1B
29glomerulonephritis10.0IL1B
30ulcerative colitis10.0TNF
31gingivitis10.0IL1B
32pleurisy10.0IL1B
33leukopenia10.0IL6
34periodontitis10.0IL1B
35acute pancreatitis10.0IL6
36thrombocytopenia10.0IL6
37coronary heart disease10.0IL6
38kaposi's sarcoma10.0IL6
39toxic shock syndrome10.0TNF, IL1B
40arthropathy10.0IL1B, TNF
41familial mediterranean fever10.0IL1B, TNF
42interstitial lung disease10.0IL1B, TNF
43blau syndrome10.0IL1B, TNF
44sarcoidosis10.0IL1B, TNF
45psoriatic arthritis10.0IL1B, TNF
46cerebral malaria10.0IL1B, TNF
47aids dementia complex10.0TNF, IL1B
48crohn's disease10.0TNF
49periodontal disease10.0TNF, IL6
50poems syndrome10.0IL6, IL1B

Graphical network of the top 20 diseases related to Benign Migratory Glossitis:



Diseases related to benign migratory glossitis

Clinical Features for Benign Migratory Glossitis

Sources:
47OMIM
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Clinical features from OMIM:

137400

Drugs & Therapeutics for Benign Migratory Glossitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Benign Migratory Glossitis

Drug clinical trials:

Search ClinicalTrials for Benign Migratory Glossitis

Search NIH Clinical Center for Benign Migratory Glossitis

Search CenterWatch for Benign Migratory Glossitis

Genetic Tests for Benign Migratory Glossitis

Anatomical Context for Benign Migratory Glossitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Benign Migratory Glossitis:

33
Skin, Tongue

Animal Models for Benign Migratory Glossitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Benign Migratory Glossitis

Sources:
51PubMed
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Articles related to Benign Migratory Glossitis:

(show all 24)
idTitleAuthorsYear
1
Benign migratory glossitis. (24413515)
2013
2
Benign migratory glossitis with fissured tongue. (22918106)
2012
3
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. (21802154)
2011
4
Predisposition of allergy in patients with benign migratory glossitis. (20674406)
2010
5
Oral pathology. Benign migratory glossitis. (20806635)
2010
6
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. (19138635)
2009
7
Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. (19575124)
2009
8
Successful treatment with cyclosporin administration for persistent benign migratory glossitis. (17408445)
2007
9
Investigation of functional gene polymorphisms: IL-1B, IL-6 and TNFA in benign migratory glossitis in Brazilian individuals. (17850436)
2007
10
Painful geographic tongue (benign migratory glossitis) in a child. (15482313)
2004
11
Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. (12517366)
2002
12
Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. (8949427)
1996
13
Symptomatic benign migratory glossitis: report of two cases and literature review. (1303549)
1992
14
Case #5. Benign migratory glossitis. (1887082)
1991
15
Differential diagnosis in dentistry: benign migratory glossitis. (3216128)
1988
16
Benign migratory glossitis in patients with juvenile diabetes. (3468467)
1987
17
Salicylic acid in alcohol in the treatment of benign superficial migratory glossitis. (6592304)
1984
18
Benign migratory glossitis and allergy. (6963406)
1982
19
Benign migratory glossitis--a cause for worry? (7334963)
1981
20
Atypical benign migratory glossitis. Report of a case with histologic and electron microscopic evaluations. (1069222)
1976
21
Benign migratory glossitis. (1054669)
1975
22
Benign migratory glossitis associated with lichen planus. (4524269)
1974
23
Hereditary component in the etiology of benign migratory glossitis. (5016506)
1972
24
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. (13088005)
1953

Genetic Variations for Benign Migratory Glossitis

Expression for genes affiliated with Benign Migratory Glossitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Benign Migratory Glossitis

Search GEO for disease gene expression data for Benign Migratory Glossitis.

Pathways for genes affiliated with Benign Migratory Glossitis

Sources:
30KEGG, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Benign Migratory Glossitis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL1B
29.7TNF
39.3IL1B, IL6
4
Hide members
9.3IL6, IL1B
59.3IL6, IL1B
6
Hide members
9.3IL1B, IL6
79.3IL6, IL1B
89.1IL1B, TNF
99.1IL1B, TNF
109.1IL1B, TNF
119.1IL1B, TNF
129.0TNF, IL6
139.0IL6, TNF
14
Hide members
8.5IL6, IL1B, TNF
15
Hide members
8.5TNF, IL1B, IL6
16
Hide members
8.5TNF, IL1B, IL6
17
Hide members
8.5IL6, IL1B, TNF
188.5IL6, IL1B, TNF
198.5TNF, IL1B, IL6
208.5TNF, IL1B, IL6
218.5TNF, IL1B, IL6
22
Immune response Bacterial infections in normal airways
Hide members
8.5IL6, IL1B, TNF
23
Hide members
8.5TNF, IL1B, IL6
248.5TNF, IL1B, IL6
258.5TNF, IL1B, IL6
26
Hide members
8.5TNF, IL1B, IL6
27
Hide members
8.5IL6, IL1B, TNF
28
Hide members
8.5TNF, IL1B, IL6
298.5IL6, IL1B, TNF
30
Development PDGF signaling via STATs and NF-kB
Hide members
8.5IL6, IL1B, TNF
318.5TNF, IL1B, IL6
328.5TNF, IL1B, IL6
338.5IL6, IL1B, TNF
34
Hide members
8.5TNF, IL1B, IL6

Compounds for genes affiliated with Benign Migratory Glossitis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Benign Migratory Glossitis according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1troglitazone45 29 60 1113.3IL1B
2gm-csf45 2911.1TNF
3actinomycin4510.1IL1B
4muramyl tripeptide phosphatidylethanolamine459.7IL1B, IL6
5turpentine459.7IL6, IL1B
6bucillamine459.6IL6, IL1B
7hbd2459.5IL6, IL1B
8n,n-dimethylsphingosine45 6010.4IL1B, TNF
9tocilizumab45 1110.4IL6, TNF
10abatacept45 1110.4IL6, TNF
11cicaprost45 2910.4IL1B, TNF
12cdp571459.4IL6, TNF
13toxin-1459.3IL1B, TNF
14helenalin459.2IL6, IL1B
15gold sodium thiomalate459.1TNF, IL1B
16anakinra45 1110.0IL6, TNF, IL1B
17taurine chloramine459.0IL1B, IL6, TNF
18vesnarinone459.0IL6, TNF, IL1B
19mip 1alpha459.0IL6, IL1B, TNF
20il-12459.0TNF, IL6, IL1B
21tpck459.0IL6, IL1B, TNF
22polymyxin b458.9IL1B, IL6, TNF
23leflunomide50 45 1110.9IL6, IL1B, TNF
24groalpha458.9IL6, TNF, IL1B
25triptolide458.9IL6, IL1B, TNF
26ciglitazone45 299.9IL6, TNF, IL1B
27lipoteichoic acid458.9TNF, IL1B, IL6
28polyinosinic-polycytidylic acid458.9TNF, IL1B, IL6
29etanercept45 50 1110.9IL6, IL1B, TNF
30poly(i-c)458.9IL6, IL1B, TNF
31il 10458.9TNF, IL6, IL1B
32infliximab45 50 1110.9IL1B, IL6, TNF
33peptidoglycan45 299.9TNF, IL6, IL1B
34ccl345 299.9TNF, IL1B, IL6
35neopterin458.9IL6, TNF, IL1B
3615-deoxy-delta-12,14-prostaglandin j2458.9TNF, IL1B, IL6
37pdtc458.9IL6, TNF, IL1B
38thalidomide45 50 60 1111.9TNF, IL6, IL1B
39anisomycin45 119.9TNF, IL1B, IL6
40leukotriene b445 60 2410.9IL6, TNF, IL1B
41sp 60012545 609.8IL1B, IL6, TNF
42tgf beta1458.8IL1B, TNF, IL6
43herbimycin a45 609.8TNF, IL6, IL1B
44curcumin458.8IL6, IL1B, TNF
45prostaglandin458.8TNF, IL1B, IL6
46calcitriol45 60 11 2411.7IL6, TNF, IL1B
47methotrexate45 50 1110.7IL6, IL1B, TNF
48rantes458.6IL6, IL1B, TNF
49indomethacin45 60 29 1111.5IL1B, IL6, TNF
50n acetylcysteine458.2IL1B, IL6, TNF

GO Terms for genes affiliated with Benign Migratory Glossitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Benign Migratory Glossitis according to GeneCards/GeneDecks:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell proliferationGO:0421029.6IL1B, IL6
2sequestering of triglycerideGO:0307309.6IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:0341169.5IL1B, TNF
5positive regulation of fever generationGO:0316229.5IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:0450809.5IL1B, TNF
7regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.5IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.5TNF, IL1B
9negative regulation of lipid catabolic processGO:0509959.5IL1B, TNF
10positive regulation of NF-kappaB import into nucleusGO:0423469.5TNF, IL1B
11negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1B, TNF
12lipopolysaccharide-mediated signaling pathwayGO:0316639.5IL1B, TNF
13positive regulation of mitosisGO:0458409.5IL1B, TNF
14cellular response to organic cyclic compoundGO:0714079.5TNF, IL1B
15protein kinase B signaling cascadeGO:0434919.5IL1B, TNF
16positive regulation of interferon-gamma productionGO:0327299.4IL1B, TNF
17epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
18negative regulation of lipid storageGO:0108889.4TNF, IL6
19positive regulation of chemokine productionGO:0327229.4IL6, TNF
20positive regulation of JNK cascadeGO:0463309.4IL1B, TNF
21negative regulation of fat cell differentiationGO:0455999.4IL6, TNF
22defense response to Gram-positive bacteriumGO:0508309.3TNF, IL6
23positive regulation of smooth muscle cell proliferationGO:0486619.3IL6, TNF
24humoral immune responseGO:0069599.3IL6, TNF
25MAPK cascadeGO:0001659.3TNF, IL1B
26response to mechanical stimulusGO:0096129.3TNF, IL6
27positive regulation of peptidyl-serine phosphorylationGO:0331389.2IL6, TNF
28regulation of insulin secretionGO:0507969.2TNF, IL1B
29response to glucocorticoid stimulusGO:0513849.2IL6, TNF
30positive regulation of protein kinase B signaling cascadeGO:0518979.1IL6, TNF
31positive regulation of protein phosphorylationGO:0019349.0TNF, IL1B
32positive regulation of ERK1 and ERK2 cascadeGO:0703749.0IL6, TNF
33positive regulation of nitric oxide biosynthetic processGO:0454298.9IL6, IL1B, TNF
34positive regulation of interleukin-6 productionGO:0327558.9TNF, IL1B, IL6
35positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9TNF, IL1B, IL6
36positive regulation of NF-kappaB transcription factor activityGO:0510928.9TNF, IL1B, IL6
37inflammatory responseGO:0069548.9TNF, IL1B, IL6
38negative regulation of cell proliferationGO:0082858.8TNF, IL1B, IL6
39activation of MAPK activityGO:0001878.8IL1B, TNF
40positive regulation of transcription, DNA-dependentGO:0458938.8TNF, IL1B, IL6
41positive regulation of transcription from RNA polymerase II promoterGO:0459448.5IL6, IL1B, TNF

Molecular functions related to Benign Migratory Glossitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5IL6, IL1B, TNF

Products for genes affiliated with Benign Migratory Glossitis

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  • Lysates
  • Antibodies

Sources for Benign Migratory Glossitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet