MCID: BNG071
MIFTS: 38

Benign Schwannoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Benign Schwannoma

Aliases & Descriptions for Benign Schwannoma:

Name: Benign Schwannoma 50 56 69
Neurilemmoma 50 56 69
Peripheral Fibroblastoma 50 56
Neurilemoma 50 56
Neurolemmoma 50

Characteristics:

Orphanet epidemiological data:

56
benign schwannoma
Prevalence: 1-9/100000 (Europe);

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA252164
UMLS via Orphanet 70 C0027809 C0854906

Summaries for Benign Schwannoma

NIH Rare Diseases : 50 schwannomas are tumors of the tissue that covers the nerves (nerve sheath). these tumors develop from a type of cell called a schwann cell, which gives these tumors their name. they are usually benign (not cancerous). although schwannomas can arise from any nerve in the body, the most common areas include the nerves of the head and neck and those involved with moving the arms and legs. common symptoms include a slow-growing mass and tinel's sign (an electric-like shock when the affected area is touched). the cause of schwannomas is unknown, but they sometimes occur in people with certain disorders including some types of neurofibromatosis. benign schwannomas are typically treated with surgery. last updated: 3/9/2015

MalaCards based summary : Benign Schwannoma, also known as neurilemmoma, is related to neurilemmoma and mediastinal neurilemmoma, and has symptoms including vertigo, facial palsy and hearing abnormality. An important gene associated with Benign Schwannoma is DES (Desmin). The drugs Anti-Bacterial Agents and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and bone.

Related Diseases for Benign Schwannoma

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to Benign Schwannoma

Symptoms & Phenotypes for Benign Schwannoma

Human phenotypes related to Benign Schwannoma:

56 32 (show all 26)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 vertigo 56 32 Frequent (79-30%) HP:0002321
2 facial palsy 56 32 Frequent (79-30%) HP:0010628
3 hearing abnormality 56 32 Frequent (79-30%) HP:0000364
4 morphological abnormality of the central nervous system 56 32 Occasional (29-5%) HP:0002011
5 intestinal polyposis 56 32 Occasional (29-5%) HP:0200008
6 nasal polyposis 56 32 Occasional (29-5%) HP:0100582
7 abnormality of the liver 56 32 Occasional (29-5%) HP:0001392
8 abnormality of the adrenal glands 56 32 Occasional (29-5%) HP:0000834
9 abnormality of the larynx 56 32 Occasional (29-5%) HP:0001600
10 abnormality of the fibula 56 32 Occasional (29-5%) HP:0002991
11 abnormality of parotid gland 56 32 Occasional (29-5%) HP:0000197
12 abnormality of the breast 56 32 Occasional (29-5%) HP:0000769
13 acute episodes of neuropathic symptoms 56 32 Occasional (29-5%) HP:0003489
14 vestibular schwannoma 56 32 Very frequent (99-80%) HP:0009588
15 peripheral schwannoma 56 32 Very frequent (99-80%) HP:0009593
16 abnormality of the temporal bone 56 32 Very frequent (99-80%) HP:0009911
17 abnormality of the twelfth cranial nerve 56 32 Occasional (29-5%) HP:0010826
18 abnormality of peripheral nervous system electrophysiology 56 32 Very frequent (99-80%) HP:0030177
19 allodynia 56 32 Frequent (79-30%) HP:0012533
20 scleral schwannoma 56 32 Very frequent (99-80%) HP:0100011
21 pain 56 Occasional (29-5%)
22 abnormality of the cranial nerves 56 Very frequent (99-80%)
23 abnormality of the esophagus 56 Occasional (29-5%)
24 schwannoma 56 Very frequent (99-80%)
25 neurofibrosarcoma 56 Excluded (0%)
26 abnormality of esophagus morphology 32 HP:0002031

Drugs & Therapeutics for Benign Schwannoma

Drugs for Benign Schwannoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
2 Gentamicins Phase 4
3 Anti-Infective Agents Phase 4,Phase 2,Phase 1,Early Phase 1
4
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
5
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
6
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
9
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
10
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
11 Alkylating Agents Phase 3,Phase 2,Phase 1
12 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
13 Protein Kinase Inhibitors Phase 2, Phase 3,Early Phase 1
14 Isophosphamide mustard Phase 3,Phase 2
15 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
17 Prednisolone acetate Phase 3
18 Imatinib Mesylate Phase 2, Phase 3 123596
19 glucocorticoids Phase 3
20 Gastrointestinal Agents Phase 3
21 Neuroprotective Agents Phase 3
22 Hormone Antagonists Phase 3
23 Hormones Phase 3
24 Peripheral Nervous System Agents Phase 3,Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
26 Prednisolone hemisuccinate Phase 3
27 Prednisolone phosphate Phase 3
28 Protective Agents Phase 3,Phase 2
29 Antiemetics Phase 3
30 Anti-Inflammatory Agents Phase 3,Phase 2
31 Methylprednisolone acetate Phase 3
32 Methylprednisolone Hemisuccinate Phase 3
33 Autonomic Agents Phase 3
34 Antineoplastic Agents, Hormonal Phase 3
35
Etoposide Approved Phase 2 33419-42-0 36462
36
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
37
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
38
Dacarbazine Approved, Investigational Phase 2,Phase 1 4342-03-4 5351166
39
Everolimus Approved Phase 2,Phase 1,Early Phase 1 159351-69-6 6442177
40
Lenograstim Approved Phase 2 135968-09-1
41
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
42
Sirolimus Approved, Investigational Phase 2,Phase 1,Early Phase 1 53123-88-9 5284616 6436030 46835353
43
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
44
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
45
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
46
Pembrolizumab Approved Phase 2 1374853-91-4
47
nivolumab Approved Phase 2 946414-94-4
48
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
49
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
50
Xylometazoline Approved Phase 1, Phase 2 526-36-3 5709

Interventional clinical trials:

(show top 50) (show all 88)
id Name Status NCT ID Phase
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4
3 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Enrolling by invitation NCT02884154 Phase 4
4 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
5 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
6 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3
7 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
8 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
9 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
10 Imatinib Mesylate Treatment of Patients With Malignant Peripheral Nerve Sheath Tumors Terminated NCT00427583 Phase 2, Phase 3
11 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
12 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2
13 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2
14 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2
15 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2
16 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
17 S0330 Erlotinib in Treating Patients With Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumor Completed NCT00068367 Phase 2
18 Sorafenib and Dacarbazine in Soft Tissue Sarcoma Completed NCT00837148 Phase 2
19 Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors Completed NCT00304083 Phase 2
20 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
21 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
22 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Recruiting NCT01345136 Phase 2
23 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2
24 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
25 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2
26 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2
27 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Recruiting NCT02831257 Phase 2
28 A Study of Pembrolizumab in Patients With Malignant Peripheral Nerve Sheath Tumor (MPNST), Not Eligible for Curative Surgery Recruiting NCT02691026 Phase 2
29 PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors Recruiting NCT02584647 Phase 1, Phase 2
30 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Recruiting NCT02601209 Phase 1, Phase 2
31 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
32 Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2
33 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
34 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2
35 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
36 SARC023: Ganetespib and Sirolimos in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors) Active, not recruiting NCT02008877 Phase 1, Phase 2
37 SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath Tumors Active, not recruiting NCT01661283 Phase 2
38 Alisertib in Treating Patients With Advanced or Metastatic Sarcoma Active, not recruiting NCT01653028 Phase 2
39 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
40 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2
41 Study of Aspirin in Patients With Vestibular Schwannoma Not yet recruiting NCT03079999 Phase 2
42 Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors Not yet recruiting NCT02986919 Phase 2
43 PTC299 for Treatment of Neurofibromatosis Type 2 Suspended NCT00911248 Phase 2
44 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2
45 Antineoplaston Therapy in Treating Patients With Neurofibroma and Schwannoma Terminated NCT02988726 Phase 2
46 Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the Neoadjuvant Treatment of Soft Tissue Sarcoma (STS) Terminated NCT01418001 Phase 1, Phase 2
47 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
48 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
49 An Implant for Hearing Loss Due to Removal of Neurofibromatosis 2 Tumors Completed NCT00030043 Phase 1
50 Vaccine Therapy in Treating Patients With Malignant Peripheral Nerve Sheath Tumor That is Recurrent or Cannot Be Removed by Surgery Recruiting NCT02700230 Phase 1

Search NIH Clinical Center for Benign Schwannoma

Genetic Tests for Benign Schwannoma

Anatomical Context for Benign Schwannoma

MalaCards organs/tissues related to Benign Schwannoma:

39
Liver, Breast, Bone, Adrenal Gland, Colon, Pancreas, Tonsil

Publications for Benign Schwannoma

Articles related to Benign Schwannoma:

(show top 50) (show all 87)
id Title Authors Year
1
Benign schwannoma of the maxillary antrum. ( 27095911 )
2016
2
Laparoscopic resection of benign schwannoma in the hepatoduodenal ligament: A case report and review of the literature. ( 27123115 )
2016
3
Retroperitoneal schwannomas: advantages of laparoscopic resection. Review of the literature and case presentation of a large paracaval benign schwannoma (with video). ( 25598061 )
2015
4
Primary intraparotid peripheral nerve sheath tumour with characteristics of benign schwannoma in a horse. ( 24529508 )
2014
5
Benign schwannoma in supraclavicular region: a false-positive lymph node recurrence of breast cancer suspected by PET scan. ( 24744055 )
2014
6
Benign schwannoma masquerading as a malignant metastatic lesion in a patient with renal cell carcinoma. ( 25276269 )
2014
7
Recurrent benign schwannoma of the scalp: Case report. ( 23123417 )
2013
8
Rare retro-orbital intraconal occurrence of benign schwannoma - a case report. ( 24551692 )
2013
9
Elastographic and contrast-enhanced ultrasound features of a benign schwannoma of the common fibular nerve. ( 24432165 )
2013
10
A case of giant, benign schwannoma associated with total lung collapse by bloody effusion. ( 24023560 )
2013
11
Benign Schwannoma Mimicking Metastatic Lesion on F-18 FDG PET/CT in Differentiated Thyroid Cancer. ( 24900096 )
2013
12
Retroperitoneoscopic resection of a lower posterior mediastinal benign schwannoma using a transdiaphragmatic approach. ( 23652068 )
2013
13
A case of benign schwannoma of the ascending colon treated with laparoscopic-assisted wedge resection. ( 24229016 )
2013
14
Primary hepatic benign schwannoma. ( 22530081 )
2012
15
Isolated benign schwannoma of the supraorbital nerve presenting as an asymptomatic palpable mass. ( 23172454 )
2012
16
Benign schwannoma of the hepatoduodenal ligament. ( 21590600 )
2011
17
Mediastinal mass diagnosed as a benign schwannoma. ( 21947156 )
2011
18
Pancreatic benign schwannoma: combined with hemorrhage in an internal cyst. ( 21401900 )
2011
19
A case report of benign schwannoma of the liver. ( 20686285 )
2010
20
Benign schwannoma of the tonsil. ( 22767561 )
2010
21
A case of benign schwannoma of the breast: mammographic, ultrasonographic and color Doppler ultrasonographic findings. ( 19601947 )
2009
22
Concurrent benign schwannoma of oesophagus and posterior mediastinum. ( 19770133 )
2009
23
A Case of Benign Schwannoma of the Transverse Colon with Granulation Tissue. ( 20651976 )
2009
24
Retroperitoneal benign schwannoma in the suprapancreatic area. ( 18166471 )
2008
25
Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. ( 17705894 )
2008
26
Benign schwannoma of the left cervical phrenic nerve. ( 17416444 )
2008
27
Benign schwannoma of the gingiva. ( 18490606 )
2008
28
Laparoscopic resection of retroperitoneal benign schwannoma. ( 18503376 )
2008
29
Giant benign schwannoma on scalp causing 'double-head'. ( 18564825 )
2008
30
Benign schwannoma of the liver: a case report. ( 18756066 )
2008
31
Re: a benign schwannoma of the digital nerve distal to the proximal interphalangeal joint. ( 18443067 )
2008
32
Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. ( 18001365 )
2007
33
Clinical challenges and images in GI. Benign schwannoma of the pancreatic head. ( 17261290 )
2007
34
Benign schwannoma with perineurioma-like areas: A clinicopathologic study of 11 cases. ( 17041195 )
2006
35
[Benign mesenchymal stromal tumor of the breast simulating benign schwannoma in an 81-year-old male--a case report]. ( 17171974 )
2006
36
Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. ( 16163062 )
2005
37
Benign schwannoma of the pancreas. ( 15694826 )
2005
38
Solitary benign schwannoma of the external oblique muscle. ( 15114187 )
2004
39
A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. ( 15322875 )
2004
40
Primary benign schwannoma of the heart. ( 14507580 )
2003
41
Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. ( 13679444 )
2003
42
Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex. ( 12848884 )
2003
43
Retroperitoneal benign schwannoma: report of three cases and analysis of clinico-radiologic findings. ( 12962406 )
2003
44
Coexistence of benign schwannoma and lymphoma in a nasal polyp. ( 12437849 )
2002
45
Expression of E-cadherin-catenin complex in human benign schwannomas. ( 11813884 )
2002
46
Endoscopic endonasal approach for the treatment of benign schwannoma of the sinonasal tract and pterygopalatine fossa. ( 12030357 )
2002
47
Benign schwannoma in the porta hepatis. ( 11517064 )
2001
48
Benign schwannoma of the esophagus removed by enucleation: report of a case. ( 10648085 )
2000
49
Benign schwannoma. ( 10800357 )
2000
50
Laparoscopic treatment of retroperitoneal benign schwannoma. ( 10226815 )
1999

Variations for Benign Schwannoma

Expression for Benign Schwannoma

Search GEO for disease gene expression data for Benign Schwannoma.

Pathways for Benign Schwannoma

GO Terms for Benign Schwannoma

Cellular components related to Benign Schwannoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.62 DES S100A1

Biological processes related to Benign Schwannoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of heart contraction GO:0008016 8.62 DES S100A1

Molecular functions related to Benign Schwannoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.62 DES S100A1

Sources for Benign Schwannoma

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34 ICD10 via Orphanet
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43 MESH via Orphanet
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