MCID: BNG071
MIFTS: 50

Benign Schwannoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Summaries for Benign Schwannoma

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34MalaCards
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MalaCards: Benign Schwannoma, also known as neurilemmoma, is related to neurilemmoma and perineurioma. An important gene associated with Benign Schwannoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Adherens junction. The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are hearing/vestibular/ear and integument.

Aliases & Classifications for Benign Schwannoma

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Sources:
50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
benign schwannoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

benign schwannoma 50 63
neurilemmoma 50 63
peripheral fibroblastoma 50
neurolemmoma 50
neurilemoma 50


External Ids:

SNOMED-CT via Orphanet60 404022001, 985004
UMLS via Orphanet64 C0027809, C0854906

Related Diseases for Benign Schwannoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Benign Schwannoma family:

Adult Malignant Schwannoma

Diseases related to Benign Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1neurilemmoma31.9NF1, NF2
2perineurioma30.4S100B
3neurofibroma30.3NF1, S100B, ACTC1, NF2
4meningioma30.3S100B, NF2, NF1
5fibroma30.2ACTC1, DES
6leiomyoma30.1ACTC1, DES, S100B
7acoustic neuroma30.1NF1, NF2
8spindle cell sarcoma30.0ACTC1, DES, S100B
9pleomorphic adenoma29.9DES, ACTC1, S100B
10leiomyosarcoma29.9S100B, ACTC1, DES
11hemangioma29.9ACTC1, NF1
12neurofibromatosis29.9NF2, NF1
13sarcoma29.8S100B, NF1, NF2, ACTC1, DES
14malignant peripheral nerve sheath tumor29.8NF1, S100B, NF2
15melanoma29.8NF2, CDH1, S100B, ACTC1, NF1, DES
16breast cancer29.8ACTC1, CDH1, NF2
17astrocytoma29.8NF2, S100B, NF1
18thyroiditis10.3
19pancreatitis10.3
20mediastinal neurilemmoma10.3
21melanotic neurilemmoma10.3
22mediastinitis10.2
23tarsal tunnel syndrome10.2
24neurilemmoma of the fifth cranial nerve10.2
25sympathetic neurilemmoma10.2
26fasciitis10.1ACTC1
27infantile myofibromatosis10.1DES
28syringoma10.1S100B
29histiocytosis10.1S100B
30ganglioglioma10.1S100B
31papilloma10.1ACTC1
32ductal carcinoma in situ10.1CDH1
33glomus tumor10.1ACTC1, DES
34epithelioid leiomyosarcoma10.1ACTC1, DES
35pseudosarcomatous fibromatosis10.1DES, ACTC1
36spindle cell carcinoma10.1ACTC1, DES
37desmoid tumor10.1ACTC1, DES
38adenosarcoma10.1DES, ACTC1
39endometrial stromal sarcoma10.1ACTC1, DES
40rhabdoid tumor10.1DES, ACTC1
41angiomyolipoma10.1ACTC1, DES
42embryonal rhabdomyosarcoma10.1DES, ACTC1
43fibromatosis10.1ACTC1, DES
44myoepithelioma10.1ACTC1, S100B
45neurilemmoma of the pleura10.1
46benign mediastinal psammomatous neurilemmoma10.1
47mediastinal melanocytic neurilemmoma10.1
48horner's syndrome10.1
49choroiditis10.1
50plexiform schwannoma10.1

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to benign schwannoma

Symptoms for Benign Schwannoma

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Drugs & Therapeutics for Benign Schwannoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Benign Schwannoma

Drug clinical trials:

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Search NIH Clinical Center for Benign Schwannoma

Search CenterWatch for Benign Schwannoma

Genetic Tests for Benign Schwannoma

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Anatomical Context for Benign Schwannoma

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34MalaCards
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MalaCards organs/tissues related to Benign Schwannoma:

34
Liver, Breast, Colon, Pancreas, Heart, Small intestine, Lung, Tonsil, Tongue

Animal Models for Benign Schwannoma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Benign Schwannoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6CTNNA2, NF1, NF2
2MP:00107718.1S100B, NF2, NF1, CDH1
3MP:00028737.9ACTC1, S100B, NF1, CDH1
4MP:00053867.9DES, S100B, NF2, NF1, CTNNA2
5MP:00053787.7CTNNA2, CDH1, NF1, NF2, ACTC1
6MP:00053767.6CDH1, NF1, NF2, ACTC1, DES
7MP:00107687.4CTNNA2, CDH1, NF1, NF2, ACTC1, DES

Publications for Benign Schwannoma

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53PubMed
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Articles related to Benign Schwannoma:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Recurrent benign schwannoma of the scalp: Case report. (23123417)
2013
2
A case of giant, benign schwannoma associated with total lung collapse by bloody effusion. (24023560)
2013
3
Mediastinal mass diagnosed as a benign schwannoma. (21947156)
2011
4
A case report of benign schwannoma of the liver. (20686285)
2010
5
Benign schwannoma of the tonsil. (22767561)
2010
6
A Case of Benign Schwannoma of the Transverse Colon with Granulation Tissue. (20651976)
2009
7
Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. (17705894)
2008
8
Benign schwannoma of the left cervical phrenic nerve. (17416444)
2008
9
Retroperitoneal benign schwannoma in the suprapancreatic area. (18166471)
2008
10
Benign schwannoma of the liver: a case report. (18756066)
2008
11
Benign schwannoma of the gingiva. (18490606)
2008
12
Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. (18001365)
2007
13
Clinical challenges and images in GI. Benign schwannoma of the pancreatic head. (17261290)
2007
14
Benign mesenchymal stromal tumor of the breast simulating benign schwannoma in an 81-year-old male--a case report]. (17171974)
2006
15
Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. (16163062)
2005
16
A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. (15322875)
2004
17
Solitary benign schwannoma of the external oblique muscle. (15114187)
2004
18
Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. (13679444)
2003
19
Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex. (12848884)
2003
20
Retroperitoneal benign schwannoma: report of three cases and analysis of clinico-radiologic findings. (12962406)
2003
21
Coexistence of benign schwannoma and lymphoma in a nasal polyp. (12437849)
2002
22
Benign schwannoma in the porta hepatis. (11517064)
2001
23
Benign schwannoma. (10800357)
2000
24
Gigantic benign schwannoma in the lateral peroneal nerve. (10050692)
1999
25
Laparoscopic treatment of retroperitoneal benign schwannoma. (10226815)
1999
26
Benign schwannoma of the liver with cystic changes misinterpreted as hydatid disease. (9840143)
1998
27
Benign schwannoma of the obturator nerve: a case report. (9757997)
1998
28
Benign schwannoma surrounding and obstructing the ureteropelvic junction. First case report. (9266244)
1997
29
Epidermolysis bullosa acquisita and benign schwannoma. (8784289)
1996
30
Benign schwannoma of the small intestine: an unusual cause of gastrointestinal bleeding. (7636397)
1995
31
Benign schwannoma of the esophagus: report of two cases with immunohistochemical and ultrastructural studies. (8055113)
1994
32
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
33
A case of benign schwannoma of the thoracic wall mimicking a malignant tumor. (8289436)
1993
34
Benign schwannoma in the hepatoduodenal ligament: report of a case. (7681709)
1993
35
Benign schwannoma of the retroperitoneal space: case report. (8510246)
1993
36
Benign schwannoma of the esophagus presenting as a giant fibrovascular polyp. (1731684)
1992
37
Benign schwannoma of the pancreas. (1503050)
1992
38
Thoracoscopic resection of benign schwannoma. (1412391)
1992
39
Benign schwannoma of the cecum shown radiologically. (1631698)
1992
40
Pathologic quiz case 1. Benign Schwannoma of tongue. (1892627)
1991
41
Primary intrapulmonary benign schwannoma. A case with ultrastructural and immunohistochemical confirmation. (2178968)
1990
42
Pathologic quiz case 1. Benign schwannoma of the parapharyngeal space. (2306361)
1990
43
Benign schwannoma of the foot. (2746488)
1989
44
Benign schwannoma of the pterygopalatine fossa with intracranial extension: a case report. (3329510)
1987
45
Solitary benign schwannoma in the psoas muscle. (3560343)
1987
46
Malignant epithelioid schwannoma arising in a benign schwannoma. A case report. (3995488)
1985
47
Benign schwannoma. Clinical and histopathologic findings. (4009467)
1985
48
Solitary benign schwannoma of the brachial plexus. (6879406)
1983
49
Benign schwannoma of the phrenic nerve: case report. (112501)
1979
50
Benign schwannoma: demonstration of Verocay bodies using fine needle aspiration. (266346)
1977

Variations for Benign Schwannoma

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Expression for genes affiliated with Benign Schwannoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Schwannoma

Search GEO for disease gene expression data for Benign Schwannoma.

Pathways for genes affiliated with Benign Schwannoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 5Cell Signaling Technology, 54QIAGEN, 61Thomson Reuters
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Compounds for genes affiliated with Benign Schwannoma

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46Novoseek, 30IUPHAR, 25HMDB, 52PharmGKB, 12DrugBank, 3BitterDB, 62Tocris Bioscience
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Compounds related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.9S100B, DES
2ccl446 3010.8S100B, DES
3procollagen469.8DES, ACTC1
4acetaldehyde30 46 2511.7CDH1, DES
5orcein469.7DES, ACTC1, S100B
6s 100469.7S100B, ACTC1, DES
7reticulin469.6DES, ACTC1, S100B
8mucicarmine469.6S100B, ACTC1, DES
9imatinib46 52 1211.6S100B, ACTC1, DES
10hydroxyapatite469.5CDH1, S100B
11iron46 2510.5S100B, ACTC1, DES
12azathioprine46 3 52 1212.4CDH1, DES
13silver469.3CDH1, DES
14proline469.3DES, S100B, CDH1
15colchicine46 62 3 30 1213.2NF1, S100B
16lactate469.2DES, S100B, CDH1
17progestin469.1CDH1, DES
18heparin46 30 25 1212.1CDH1, S100B, DES
19methionine469.1NF1, S100B, DES
20b 723469.0DES, ACTC1, S100B, CDH1
21hematoxylin469.0CDH1, S100B, ACTC1, DES
22fatty acid469.0DES, S100B, NF1
23formaldehyde46 2510.0DES, ACTC1, S100B, CDH1
24glycogen46 2510.0CDH1, S100B, ACTC1, DES
25creatinine469.0DES, ACTC1, S100B, CDH1
26testosterone46 62 25 1212.0DES, ACTC1, S100B, CDH1
27vegf468.9CDH1, S100B, ACTC1, DES
28cytochalasin d46 629.9CDH1, NF1, NF2
29rapamycin468.8CDH1, NF1, NF2
30steroid468.8DES, ACTC1, S100B, NF1
31adenylate468.5CDH1, NF1, S100B, DES
32cyclic amp46 259.5DES, S100B, NF1, CDH1
33arginine468.5DES, S100B, NF1, CDH1
34estrogen468.2DES, ACTC1, S100B, NF1, CDH1
35retinoic acid46 259.2CDH1, NF1, S100B, ACTC1, DES
36calcium46 52 25 1211.1DES, ACTC1, S100B, NF1, CDH1
37cysteine468.0DES, S100B, NF2, NF1, CDH1
38serine468.0DES, S100B, NF2, NF1, CDH1
39paraffin467.7CDH1, NF1, NF2, S100B, ACTC1, DES
40progesterone46 30 62 25 1211.7CDH1, NF1, NF2, S100B, ACTC1, DES
41tyrosine467.7DES, ACTC1, S100B, NF2, NF1, CDH1

GO Terms for genes affiliated with Benign Schwannoma

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17Gene Ontology
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Cellular components related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:0059139.2CDH1, CTNNA2
2adherens junctionGO:0059129.1CTNNA2, NF2
3perinuclear region of cytoplasmGO:0484718.9CDH1, NF2, S100B
4cytoplasmGO:0057377.2CTNNA2, CDH1, NF1, NF2, S100B, ACTC1

Biological processes related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.8ACTC1, DES
2negative regulation of cell-cell adhesionGO:0224089.5CDH1, NF2
3axonogenesisGO:0074099.4CTNNA2, S100B
4negative regulation of cell-matrix adhesionGO:0019539.3NF1, NF2
5cell-cell junction organizationGO:0452169.3CDH1, NF2
6cell-cell adhesionGO:0163379.3CTNNA2, CDH1
7negative regulation of MAPK cascadeGO:0434099.3NF1, NF2
8negative regulation of protein kinase activityGO:0064699.2NF2, NF1
9negative regulation of cell migrationGO:0303368.8NF1, NF2

Molecular functions related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5CTNNA2, DES
2protein bindingGO:0055156.8CTNNA2, CDH1, NF1, NF2, S100B, DES

Products for genes affiliated with Benign Schwannoma

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Sources for Benign Schwannoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet