MCID: BNG071
MIFTS: 49

Benign Schwannoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Benign Schwannoma

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MalaCards based summary: Benign Schwannoma, also known as neurilemmoma, is related to perineurioma and fibroma. An important gene associated with Benign Schwannoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Adherens junction. The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are hearing/vestibular/ear and integument.

Aliases & Classifications for Benign Schwannoma

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Benign Schwannoma, Aliases & Descriptions:

Name: Benign Schwannoma 48 62
Neurilemmoma 48 62
Neurilemoma 48 62
 
Peripheral Fibroblastoma 48
Neurolemmoma 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
benign schwannoma:
Prevalence: 1-9/100000


External Ids:

UMLS via Orphanet63 C0027809, C0854906

Related Diseases for Benign Schwannoma

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Diseases in the Benign Schwannoma family:

Adult Malignant Schwannoma

Diseases related to Benign Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma31.0S100B
2fibroma30.5ACTC1, DES
3acoustic neuroma30.4NF1, NF2
4spindle cell sarcoma30.2ACTC1, DES, S100B
5neurilemmoma30.2NF1, NF2
6meningioma30.1S100B, NF2, NF1
7pleomorphic adenoma30.1DES, ACTC1, S100B
8leiomyosarcoma30.1S100B, ACTC1, DES
9leiomyoma30.1ACTC1, DES, S100B
10hemangioma30.0ACTC1, NF1
11neurofibroma29.9NF1, S100B, ACTC1, NF2
12neurofibromatosis29.9NF2, NF1
13breast cancer29.8ACTC1, CDH1, NF2
14malignant peripheral nerve sheath tumor29.7NF1, S100B, NF2
15astrocytoma29.6NF2, S100B, NF1
16sarcoma29.4S100B, NF1, NF2, ACTC1, DES
17melanoma29.0NF2, CDH1, S100B, ACTC1, NF1, DES
18fasciitis10.5ACTC1
19infantile myofibromatosis10.5DES
20syringoma10.4S100B
21histiocytosis10.4S100B
22ganglioglioma10.4S100B
23papilloma10.4ACTC1
24ductal carcinoma in situ10.3CDH1
25epithelioid leiomyosarcoma10.3ACTC1, DES
26pseudosarcomatous fibromatosis10.3DES, ACTC1
27spindle cell carcinoma10.3ACTC1, DES
28mediastinal neurilemmoma10.3
29desmoid tumor10.3ACTC1, DES
30adenosarcoma10.3DES, ACTC1
31endometrial stromal sarcoma10.3ACTC1, DES
32rhabdoid tumor10.3DES, ACTC1
33angiomyolipoma10.3ACTC1, DES
34pancreatitis10.3
35embryonal rhabdomyosarcoma10.3DES, ACTC1
36fibromatosis10.3ACTC1, DES
37myoepithelioma10.3ACTC1, S100B
38neurilemmoma of the fifth cranial nerve10.3
39melanotic neurilemmoma10.3
40abrikosov's tumor10.3ACTC1, DES
41granular cell tumor10.3DES, S100B
42sex cord-gonadal stromal tumor10.3DES, S100B
43fibrous meningioma10.3NF2, S100B
44chordoma10.2DES, S100B
45anaplastic ependymoma10.2NF2, S100B
46sympathetic neurilemmoma10.2
47benign dermal neurilemmoma10.2
48benign mediastinal neurilemmoma10.2
49mediastinitis10.2
50microphthalmia10.2S100B, ACTC1

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to benign schwannoma

Symptoms for Benign Schwannoma

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Drugs & Therapeutics for Benign Schwannoma

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Drug clinical trials:

Search ClinicalTrials for Benign Schwannoma

Search NIH Clinical Center for Benign Schwannoma

Genetic Tests for Benign Schwannoma

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Anatomical Context for Benign Schwannoma

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MalaCards organs/tissues related to Benign Schwannoma:

32
Liver, Breast, Colon, Pancreas, Lymph node, Heart, Small intestine, Lung, Thyroid, Tonsil, Tongue

Animal Models for Benign Schwannoma or affiliated genes

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MGI Mouse Phenotypes related to Benign Schwannoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6CTNNA2, NF1, NF2
2MP:00107718.1S100B, NF2, NF1, CDH1
3MP:00028737.9ACTC1, S100B, NF1, CDH1
4MP:00053867.9DES, S100B, NF2, NF1, CTNNA2
5MP:00053787.7CTNNA2, CDH1, NF1, NF2, ACTC1
6MP:00053767.6CDH1, NF1, NF2, ACTC1, DES
7MP:00107687.4CTNNA2, CDH1, NF1, NF2, ACTC1, DES

Publications for Benign Schwannoma

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Articles related to Benign Schwannoma:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Recurrent benign schwannoma of the scalp: Case report. (23123417)
2013
2
Rare retro-orbital intraconal occurrence of benign schwannoma - a case report. (24551692)
2013
3
A case of giant, benign schwannoma associated with total lung collapse by bloody effusion. (24023560)
2013
4
Benign Schwannoma Mimicking Metastatic Lesion on F-18 FDG PET/CT in Differentiated Thyroid Cancer. (24900096)
2013
5
Mediastinal mass diagnosed as a benign schwannoma. (21947156)
2011
6
A case report of benign schwannoma of the liver. (20686285)
2010
7
Benign schwannoma of the tonsil. (22767561)
2010
8
A Case of Benign Schwannoma of the Transverse Colon with Granulation Tissue. (20651976)
2009
9
Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. (17705894)
2008
10
Benign schwannoma of the left cervical phrenic nerve. (17416444)
2008
11
Retroperitoneal benign schwannoma in the suprapancreatic area. (18166471)
2008
12
Benign schwannoma of the liver: a case report. (18756066)
2008
13
Benign schwannoma of the gingiva. (18490606)
2008
14
Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. (18001365)
2007
15
Clinical challenges and images in GI. Benign schwannoma of the pancreatic head. (17261290)
2007
16
Benign mesenchymal stromal tumor of the breast simulating benign schwannoma in an 81-year-old male--a case report]. (17171974)
2006
17
Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. (16163062)
2005
18
A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. (15322875)
2004
19
Solitary benign schwannoma of the external oblique muscle. (15114187)
2004
20
Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. (13679444)
2003
21
Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex. (12848884)
2003
22
Endoscopic endonasal approach for the treatment of benign schwannoma of the sinonasal tract and pterygopalatine fossa. (12030357)
2002
23
Coexistence of benign schwannoma and lymphoma in a nasal polyp. (12437849)
2002
24
Benign schwannoma. (10800357)
2000
25
Gigantic benign schwannoma in the lateral peroneal nerve. (10050692)
1999
26
Laparoscopic treatment of retroperitoneal benign schwannoma. (10226815)
1999
27
Benign schwannoma of the liver with cystic changes misinterpreted as hydatid disease. (9840143)
1998
28
Benign schwannoma of the obturator nerve: a case report. (9757997)
1998
29
Benign schwannoma surrounding and obstructing the ureteropelvic junction. First case report. (9266244)
1997
30
Epidermolysis bullosa acquisita and benign schwannoma. (8784289)
1996
31
Benign schwannoma of the small intestine: an unusual cause of gastrointestinal bleeding. (7636397)
1995
32
Benign schwannoma of the esophagus: report of two cases with immunohistochemical and ultrastructural studies. (8055113)
1994
33
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
34
A case of benign schwannoma of the thoracic wall mimicking a malignant tumor. (8289436)
1993
35
Benign schwannoma in the hepatoduodenal ligament: report of a case. (7681709)
1993
36
Benign schwannoma of the esophagus presenting as a giant fibrovascular polyp. (1731684)
1992
37
Benign schwannoma of the pancreas. (1503050)
1992
38
Thoracoscopic resection of benign schwannoma. (1412391)
1992
39
Benign schwannoma of the cecum shown radiologically. (1631698)
1992
40
Pathologic quiz case 1. Benign Schwannoma of tongue. (1892627)
1991
41
Primary intrapulmonary benign schwannoma. A case with ultrastructural and immunohistochemical confirmation. (2178968)
1990
42
Benign schwannoma and parathyroid adenoma occurring in the nonradiated neck: report of two cases. (2325424)
1990
43
Benign schwannoma of the foot. (2746488)
1989
44
Benign schwannoma of the pterygopalatine fossa with intracranial extension: a case report. (3329510)
1987
45
Solitary benign schwannoma in the psoas muscle. (3560343)
1987
46
Malignant epithelioid schwannoma arising in a benign schwannoma. A case report. (3995488)
1985
47
Benign schwannoma. Clinical and histopathologic findings. (4009467)
1985
48
Solitary benign schwannoma of the brachial plexus. (6879406)
1983
49
Benign schwannoma of the phrenic nerve: case report. (112501)
1979
50
Benign schwannoma: demonstration of Verocay bodies using fine needle aspiration. (266346)
1977

Variations for Benign Schwannoma

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Expression for genes affiliated with Benign Schwannoma

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Expression patterns in normal tissues for genes affiliated with Benign Schwannoma

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Pathways for genes affiliated with Benign Schwannoma

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Compounds for genes affiliated with Benign Schwannoma

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Compounds related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9S100B, DES
2ccl444 2810.8S100B, DES
3procollagen449.8DES, ACTC1
4acetaldehyde28 44 2411.7CDH1, DES
5orcein449.7DES, ACTC1, S100B
6s 100449.7S100B, ACTC1, DES
7reticulin449.6DES, ACTC1, S100B
8mucicarmine449.6S100B, ACTC1, DES
9imatinib44 50 1111.6S100B, ACTC1, DES
10hydroxyapatite449.5CDH1, S100B
11iron44 2410.5S100B, ACTC1, DES
12azathioprine44 2 50 1112.4CDH1, DES
13silver449.3CDH1, DES
14proline449.3DES, S100B, CDH1
15colchicine44 61 2 28 1113.2NF1, S100B
16lactate449.2DES, S100B, CDH1
17progestin449.1CDH1, DES
18heparin44 28 24 1112.1CDH1, S100B, DES
19methionine449.1NF1, S100B, DES
20b 723449.0DES, ACTC1, S100B, CDH1
21hematoxylin449.0CDH1, S100B, ACTC1, DES
22fatty acid449.0DES, S100B, NF1
23formaldehyde44 2410.0DES, ACTC1, S100B, CDH1
24glycogen44 2410.0CDH1, S100B, ACTC1, DES
25creatinine449.0DES, ACTC1, S100B, CDH1
26testosterone44 61 24 1112.0DES, ACTC1, S100B, CDH1
27vegf448.9CDH1, S100B, ACTC1, DES
28cytochalasin d44 619.9CDH1, NF1, NF2
29rapamycin448.8CDH1, NF1, NF2
30steroid448.8DES, ACTC1, S100B, NF1
31adenylate448.5CDH1, NF1, S100B, DES
32cyclic amp44 249.5DES, S100B, NF1, CDH1
33arginine448.5DES, S100B, NF1, CDH1
34estrogen448.2DES, ACTC1, S100B, NF1, CDH1
35retinoic acid44 249.2CDH1, NF1, S100B, ACTC1, DES
36calcium44 50 24 1111.1DES, ACTC1, S100B, NF1, CDH1
37cysteine448.0DES, S100B, NF2, NF1, CDH1
38serine448.0DES, S100B, NF2, NF1, CDH1
39paraffin447.7CDH1, NF1, NF2, S100B, ACTC1, DES
40progesterone44 28 61 24 1111.7CDH1, NF1, NF2, S100B, ACTC1, DES
41tyrosine447.7DES, ACTC1, S100B, NF2, NF1, CDH1

GO Terms for genes affiliated with Benign Schwannoma

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Cellular components related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:0059139.2CDH1, CTNNA2
2adherens junctionGO:0059129.1CTNNA2, NF2
3perinuclear region of cytoplasmGO:0484718.9CDH1, NF2, S100B
4cytoplasmGO:0057377.2CTNNA2, CDH1, NF1, NF2, S100B, ACTC1

Biological processes related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.8ACTC1, DES
2negative regulation of cell-cell adhesionGO:0224089.5CDH1, NF2
3axonogenesisGO:0074099.4CTNNA2, S100B
4negative regulation of cell-matrix adhesionGO:0019539.3NF1, NF2
5cell-cell junction organizationGO:0452169.3CDH1, NF2
6cell-cell adhesionGO:0163379.3CTNNA2, CDH1
7negative regulation of MAPK cascadeGO:0434099.3NF1, NF2
8negative regulation of protein kinase activityGO:0064699.2NF2, NF1
9negative regulation of cell migrationGO:0303368.8NF1, NF2

Molecular functions related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5CTNNA2, DES
2protein bindingGO:0055156.8CTNNA2, CDH1, NF1, NF2, S100B, DES

Products for genes affiliated with Benign Schwannoma

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Sources for Benign Schwannoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet