MCID: BNG071
MIFTS: 34

Benign Schwannoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Benign Schwannoma

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32MalaCards
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MalaCards: Benign Schwannoma, also known as neurilemmoma, is related to neurilemmoma and neurofibroma. An important gene associated with Benign Schwannoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Hypertrophic cardiomyopathy (HCM). The compounds glycogen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and mortality/aging.

Aliases & Classifications for Benign Schwannoma

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
benign schwannoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

benign schwannoma 48 60
neurilemmoma 48 60
peripheral fibroblastoma 48
neurolemmoma 48
neurilemoma 48


External Ids:

SNOMED-CT via Orphanet57 404022001, 985004

Related Diseases for Benign Schwannoma

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17GeneCards, 18GeneDecks
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Diseases in the Benign Schwannoma family:

Adult Malignant Schwannoma

Diseases related to Benign Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1neurilemmoma31.7NF1, NF2
2neurofibroma30.3S100B, NF2, NF1, ACTC1
3meningioma30.2S100B, NF2, NF1
4perineurioma30.2S100B
5leiomyoma30.0ACTC1, DES, S100B
6acoustic neuroma30.0NF1, NF2
7adenoma30.0ACTC1, CDH1
8malignant peripheral nerve sheath tumor29.9S100B, NF2, NF1
9melanoma29.9S100B, DES, NF2, NF1, CDH1, ACTC1
10spindle cell sarcoma29.9ACTC1, DES, S100B
11sarcoma29.9ACTC1, NF1, NF2, DES, S100B
12ganglioneuroma29.8S100B
13hemangioma29.8NF1, ACTC1
14leiomyosarcoma29.8S100B, DES, ACTC1
15pleomorphic adenoma29.8S100B, DES, ACTC1
16neurofibromatosis29.8NF1, NF2
17breast cancer29.7CDH1, NF1, NF2
18sympathetic neurilemmoma10.3
19mediastinal neurilemmoma10.3
20thyroiditis10.3
21pancreatitis10.2
22melanotic neurilemmoma10.2
23mediastinitis10.1
24tarsal tunnel syndrome10.1
25plexiform schwannoma10.1
26neurilemmoma of the fifth cranial nerve10.1
27neurilemmomatosis10.1
28peptic ulcer10.1
29choroiditis10.0
30macrocystic neurilemmoma10.0
31neurilemmoma of the pleura10.0
32benign mediastinal psammomatous neurilemmoma10.0
33mediastinal melanocytic neurilemmoma10.0
34thoracic outlet syndrome10.0
35horner's syndrome10.0
36benign dermal neurilemmoma10.0
37cellular schwannoma10.0
38epidermolysis bullosa acquisita10.0
39carney complex10.0
40epithelioid malignant peripheral nerve sheath tumor10.0
41tonsillitis10.0
42benign mediastinal neurilemmoma10.0
43cervicitis10.0
44epidermolysis bullosa10.0
45esophagitis10.0
46hepatitis10.0
47liver disease10.0
48parathyroid adenoma10.0
49peripheral nerve schwannoma10.0
50fasciitis10.0ACTC1

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to benign schwannoma

Clinical Features for Benign Schwannoma

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Drugs & Therapeutics for Benign Schwannoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Benign Schwannoma

Drug clinical trials:

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Search NIH Clinical Center for Benign Schwannoma

Search CenterWatch for Benign Schwannoma

Genetic Tests for Benign Schwannoma

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Anatomical Context for Benign Schwannoma

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Animal Models for Benign Schwannoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Benign Schwannoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.7NF1, NF2, DES, CTNNA2, S100B
2MP:00107686.9ACTC1, CTNNA2, DES, NF2, NF1, CDH1

Publications for Benign Schwannoma

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Genetic Variations for Benign Schwannoma

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Expression for genes affiliated with Benign Schwannoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Schwannoma

Search GEO for disease gene expression data for Benign Schwannoma.

Pathways for genes affiliated with Benign Schwannoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Benign Schwannoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.5ACTC1
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7S100B, DES
3orcein449.6ACTC1, DES, S100B
4s 100449.6ACTC1, DES, S100B
5reticulin449.6ACTC1, S100B, DES
6mucicarmine449.5ACTC1, S100B, DES
7imatinib44 49 1111.5ACTC1, S100B, DES
8acetaldehyde44 28 2411.4DES, CDH1
9ccl444 2810.2S100B, DES
10iron44 2410.2ACTC1, DES, S100B
11proline449.0CDH1, S100B, DES
12b 723449.0ACTC1, CDH1, DES, S100B
13methionine448.9S100B, DES, NF1
14hematoxylin448.9S100B, ACTC1, DES, CDH1
15lactate448.9S100B, DES, CDH1
16formaldehyde44 249.9S100B, ACTC1, CDH1, DES
17cytochalasin d44 599.9NF1, CDH1, NF2
18creatinine448.9CDH1, S100B, ACTC1, DES
19testosterone44 59 11 2411.8ACTC1, S100B, CDH1, DES
20vegf448.8S100B, CDH1, ACTC1, DES
21rapamycin448.8NF1, NF2, CDH1
22steroid448.6DES, NF1, S100B, ACTC1
23fatty acid448.6DES, S100B, NF1
24adenylate448.4S100B, DES, CDH1, NF1
25cyclic amp44 249.4NF1, S100B, CDH1, DES
26arginine448.3S100B, NF1, CDH1, DES
27estrogen448.1S100B, DES, CDH1, ACTC1, NF1
28retinoic acid44 249.1S100B, DES, ACTC1, CDH1, NF1
29cysteine448.0NF1, NF2, DES, S100B, CDH1
30serine447.9NF2, NF1, CDH1, DES, S100B
31calcium44 49 11 2410.9CDH1, ACTC1, DES, NF1, S100B
32paraffin447.7CDH1, S100B, NF2, DES, ACTC1, NF1
33progesterone44 59 28 11 2411.7S100B, DES, NF1, CDH1, ACTC1, NF2
34tyrosine447.6NF2, S100B, DES, NF1, CDH1, ACTC1

GO Terms for genes affiliated with Benign Schwannoma

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16Gene Ontology
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Cellular components related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:0059139.2CTNNA2, CDH1
2adherens junctionGO:0059129.2CTNNA2, NF2
3cytoplasmGO:0057377.3S100B, CTNNA2, NF2, NF1, CDH1, ACTC1

Biological processes related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5DES, ACTC1
2negative regulation of cell-cell adhesionGO:0224089.4CDH1, NF2
3cell-cell junction organizationGO:0452169.4CDH1, NF2
4negative regulation of cell-matrix adhesionGO:0019539.3NF1, NF2
5negative regulation of MAPK cascadeGO:0434099.3NF2, NF1
6negative regulation of protein kinase activityGO:0064698.9NF2, NF1

Molecular functions related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletal protein bindingGO:0080929.5NF2, DES

Products for genes affiliated with Benign Schwannoma

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Sources for Benign Schwannoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet