MCID: BNG071
MIFTS: 42

Benign Schwannoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Summaries for Benign Schwannoma

About this section


MalaCards based summary: Benign Schwannoma, also known as neurilemmoma, is related to perineurioma and fibroma. An important gene associated with Benign Schwannoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Adherens junction. The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and colon, and related mouse phenotypes are hearing/vestibular/ear and integument.

Aliases & Classifications for Benign Schwannoma

About this section
Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Benign Schwannoma, Aliases & Descriptions:

Name: Benign Schwannoma 47 60
Neurilemmoma 47 60
Peripheral Fibroblastoma 47
 
Neurolemmoma 47
Neurilemoma 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
benign schwannoma:
Prevalence: 1-9/100000 (Europe)


External Ids:

Orphanet47 252164
UMLS via Orphanet61 C0027809, C0854906

Related Diseases for Benign Schwannoma

About this section

Diseases in the Benign Schwannoma family:

Adult Malignant Schwannoma

Diseases related to Benign Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma31.0S100B
2fibroma30.5ACTC1, DES
3leiomyoma30.3DES, ACTC1, S100B
4spindle cell sarcoma30.2S100B, ACTC1, DES
5acoustic neuroma30.2NF1, NF2
6neurilemmoma30.2NF1, NF2
7pleomorphic adenoma30.1DES, ACTC1, S100B
8malignant peripheral nerve sheath tumor30.1S100B, NF2, NF1
9leiomyosarcoma30.1DES, ACTC1, S100B
10neurofibroma30.0ACTC1, S100B, NF2, NF1
11hemangioma30.0NF1, ACTC1
12neurofibromatosis29.9NF1, NF2
13breast cancer29.8CDH1, NF2, ACTC1
14astrocytoma29.6S100B, NF2, NF1
15sarcoma29.4DES, ACTC1, S100B, NF2, NF1
16melanoma29.0DES, ACTC1, S100B, NF2, NF1, CDH1
17fasciitis10.5ACTC1
18infantile myofibromatosis10.5DES
19syringoma10.4S100B
20histiocytosis10.4S100B
21ganglioglioma10.4S100B
22papilloma10.4ACTC1
23ductal carcinoma in situ10.3CDH1
24glomus tumor10.3DES, ACTC1
25epithelioid leiomyosarcoma10.3DES, ACTC1
26mediastinal neurilemmoma10.3
27melanotic neurilemmoma10.3
28pseudosarcomatous fibromatosis10.3DES, ACTC1
29spindle cell carcinoma10.3ACTC1, DES
30desmoid disease, hereditary10.3DES, ACTC1
31adenosarcoma10.3DES, ACTC1
32endometrial stromal sarcoma10.3ACTC1, DES
33rhabdoid tumor10.3DES, ACTC1
34pancreatitis10.3
35angiomyolipoma10.3DES, ACTC1
36embryonal rhabdomyosarcoma10.3ACTC1, DES
37myoepithelioma10.3ACTC1, S100B
38fibromatosis10.3DES, ACTC1
39abrikosov's tumor10.3DES, ACTC1
40granular cell tumor10.3DES, S100B
41sex cord-gonadal stromal tumor10.3S100B, DES
42fibrous meningioma10.2NF2, S100B
43chordoma10.2S100B, DES
44neurilemmoma of the fifth cranial nerve10.2
45sympathetic neurilemmoma10.2
46anaplastic ependymoma10.2NF2, S100B
47mediastinitis10.2
48microphthalmia10.2ACTC1, S100B
49tubular adenocarcinoma10.2CDH1, ACTC1
50neurilemmoma of the pleura10.2

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to benign schwannoma

Symptoms for Benign Schwannoma

About this section

Drugs & Therapeutics for Benign Schwannoma

About this section

Drug clinical trials:

Search ClinicalTrials for Benign Schwannoma

Search NIH Clinical Center for Benign Schwannoma

Genetic Tests for Benign Schwannoma

About this section

Anatomical Context for Benign Schwannoma

About this section

MalaCards organs/tissues related to Benign Schwannoma:

31
Liver, Breast, Colon, Pancreas, Lymph node, Heart, Small intestine, Lung, Thyroid, Tonsil, Tongue

Animal Models for Benign Schwannoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Benign Schwannoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6CTNNA2, NF1, NF2
2MP:00107718.1S100B, NF2, NF1, CDH1
3MP:00028737.9ACTC1, S100B, NF1, CDH1
4MP:00053867.9DES, S100B, NF2, NF1, CTNNA2
5MP:00053787.7CTNNA2, CDH1, NF1, NF2, ACTC1
6MP:00053767.6CDH1, NF1, NF2, ACTC1, DES
7MP:00107687.4CTNNA2, CDH1, NF1, NF2, ACTC1, DES

Publications for Benign Schwannoma

About this section

Articles related to Benign Schwannoma:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Recurrent benign schwannoma of the scalp: Case report. (23123417)
2013
2
Rare retro-orbital intraconal occurrence of benign schwannoma - a case report. (24551692)
2013
3
A case of giant, benign schwannoma associated with total lung collapse by bloody effusion. (24023560)
2013
4
Benign Schwannoma Mimicking Metastatic Lesion on F-18 FDG PET/CT in Differentiated Thyroid Cancer. (24900096)
2013
5
Mediastinal mass diagnosed as a benign schwannoma. (21947156)
2011
6
A case report of benign schwannoma of the liver. (20686285)
2010
7
Benign schwannoma of the tonsil. (22767561)
2010
8
A Case of Benign Schwannoma of the Transverse Colon with Granulation Tissue. (20651976)
2009
9
Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. (17705894)
2008
10
Benign schwannoma of the left cervical phrenic nerve. (17416444)
2008
11
Retroperitoneal benign schwannoma in the suprapancreatic area. (18166471)
2008
12
Benign schwannoma of the liver: a case report. (18756066)
2008
13
Benign schwannoma of the gingiva. (18490606)
2008
14
Primary benign schwannoma of the left ventricle coursing under the left anterior descending artery. (18001365)
2007
15
Clinical challenges and images in GI. Benign schwannoma of the pancreatic head. (17261290)
2007
16
Benign mesenchymal stromal tumor of the breast simulating benign schwannoma in an 81-year-old male--a case report]. (17171974)
2006
17
Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. (16163062)
2005
18
A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. (15322875)
2004
19
Solitary benign schwannoma of the external oblique muscle. (15114187)
2004
20
Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. (13679444)
2003
21
Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex. (12848884)
2003
22
Endoscopic endonasal approach for the treatment of benign schwannoma of the sinonasal tract and pterygopalatine fossa. (12030357)
2002
23
Coexistence of benign schwannoma and lymphoma in a nasal polyp. (12437849)
2002
24
Benign schwannoma. (10800357)
2000
25
Gigantic benign schwannoma in the lateral peroneal nerve. (10050692)
1999
26
Laparoscopic treatment of retroperitoneal benign schwannoma. (10226815)
1999
27
Benign schwannoma of the liver with cystic changes misinterpreted as hydatid disease. (9840143)
1998
28
Benign schwannoma of the obturator nerve: a case report. (9757997)
1998
29
Benign schwannoma surrounding and obstructing the ureteropelvic junction. First case report. (9266244)
1997
30
Epidermolysis bullosa acquisita and benign schwannoma. (8784289)
1996
31
Benign schwannoma of the small intestine: an unusual cause of gastrointestinal bleeding. (7636397)
1995
32
Benign schwannoma of the esophagus: report of two cases with immunohistochemical and ultrastructural studies. (8055113)
1994
33
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
34
A case of benign schwannoma of the thoracic wall mimicking a malignant tumor. (8289436)
1993
35
Benign schwannoma in the hepatoduodenal ligament: report of a case. (7681709)
1993
36
Benign schwannoma of the esophagus presenting as a giant fibrovascular polyp. (1731684)
1992
37
Benign schwannoma of the pancreas. (1503050)
1992
38
Thoracoscopic resection of benign schwannoma. (1412391)
1992
39
Benign schwannoma of the cecum shown radiologically. (1631698)
1992
40
Pathologic quiz case 1. Benign Schwannoma of tongue. (1892627)
1991
41
Primary intrapulmonary benign schwannoma. A case with ultrastructural and immunohistochemical confirmation. (2178968)
1990
42
Benign schwannoma and parathyroid adenoma occurring in the nonradiated neck: report of two cases. (2325424)
1990
43
Benign schwannoma of the foot. (2746488)
1989
44
Benign schwannoma of the pterygopalatine fossa with intracranial extension: a case report. (3329510)
1987
45
Solitary benign schwannoma in the psoas muscle. (3560343)
1987
46
Malignant epithelioid schwannoma arising in a benign schwannoma. A case report. (3995488)
1985
47
Benign schwannoma. Clinical and histopathologic findings. (4009467)
1985
48
Solitary benign schwannoma of the brachial plexus. (6879406)
1983
49
Benign schwannoma of the phrenic nerve: case report. (112501)
1979
50
Benign schwannoma: demonstration of Verocay bodies using fine needle aspiration. (266346)
1977

Variations for Benign Schwannoma

About this section

Expression for genes affiliated with Benign Schwannoma

About this section
Search GEO for disease gene expression data for Benign Schwannoma.

Pathways for genes affiliated with Benign Schwannoma

About this section

Compounds for genes affiliated with Benign Schwannoma

About this section

Compounds related to Benign Schwannoma according to GeneCards Suite gene sharing:

(show all 41)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.9S100B, DES
2ccl443 2810.8S100B, DES
3procollagen439.8DES, ACTC1
4acetaldehyde28 43 2411.7CDH1, DES
5orcein439.7DES, ACTC1, S100B
6s 100439.7S100B, ACTC1, DES
7reticulin439.6DES, ACTC1, S100B
8mucicarmine439.6S100B, ACTC1, DES
9imatinib43 49 1211.6S100B, ACTC1, DES
10hydroxyapatite439.5CDH1, S100B
11iron43 2410.5S100B, ACTC1, DES
12azathioprine43 2 49 1212.4CDH1, DES
13silver439.3CDH1, DES
14proline439.3DES, S100B, CDH1
15colchicine43 59 2 28 1213.2NF1, S100B
16lactate439.2DES, S100B, CDH1
17progestin439.1CDH1, DES
18heparin43 28 24 1212.1CDH1, S100B, DES
19methionine439.1NF1, S100B, DES
20b 723439.0DES, ACTC1, S100B, CDH1
21hematoxylin439.0CDH1, S100B, ACTC1, DES
22fatty acid439.0DES, S100B, NF1
23formaldehyde43 2410.0DES, ACTC1, S100B, CDH1
24glycogen43 2410.0CDH1, S100B, ACTC1, DES
25creatinine439.0DES, ACTC1, S100B, CDH1
26testosterone43 59 24 1212.0DES, ACTC1, S100B, CDH1
27vegf438.9CDH1, S100B, ACTC1, DES
28cytochalasin d43 599.9CDH1, NF1, NF2
29rapamycin438.8CDH1, NF1, NF2
30steroid438.8DES, ACTC1, S100B, NF1
31adenylate438.5CDH1, NF1, S100B, DES
32cyclic amp43 249.5DES, S100B, NF1, CDH1
33arginine438.5DES, S100B, NF1, CDH1
34estrogen438.2DES, ACTC1, S100B, NF1, CDH1
35retinoic acid43 249.2CDH1, NF1, S100B, ACTC1, DES
36calcium43 49 24 1211.1DES, ACTC1, S100B, NF1, CDH1
37cysteine438.0DES, S100B, NF2, NF1, CDH1
38serine438.0DES, S100B, NF2, NF1, CDH1
39paraffin437.7CDH1, NF1, NF2, S100B, ACTC1, DES
40progesterone43 28 59 24 1211.7CDH1, NF1, NF2, S100B, ACTC1, DES
41tyrosine437.7DES, ACTC1, S100B, NF2, NF1, CDH1

GO Terms for genes affiliated with Benign Schwannoma

About this section

Cellular components related to Benign Schwannoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:00059139.2CDH1, CTNNA2
2adherens junctionGO:00059129.1CTNNA2, NF2
3perinuclear region of cytoplasmGO:00484718.9CDH1, NF2, S100B
4cytoplasmGO:00057377.2CTNNA2, CDH1, NF1, NF2, S100B, ACTC1

Biological processes related to Benign Schwannoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.8ACTC1, DES
2negative regulation of cell-cell adhesionGO:00224089.5CDH1, NF2
3axonogenesisGO:00074099.4CTNNA2, S100B
4negative regulation of cell-matrix adhesionGO:00019539.3NF1, NF2
5cell-cell junction organizationGO:00452169.3CDH1, NF2
6cell-cell adhesionGO:00163379.3CTNNA2, CDH1
7negative regulation of MAPK cascadeGO:00434099.3NF1, NF2
8negative regulation of protein kinase activityGO:00064699.2NF2, NF1
9negative regulation of cell migrationGO:00303368.8NF1, NF2

Molecular functions related to Benign Schwannoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.5CTNNA2, DES
2protein bindingGO:00055156.8CTNNA2, CDH1, NF1, NF2, S100B, DES

Products for genes affiliated with Benign Schwannoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Benign Schwannoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet