MCID: BNG071
MIFTS: 38

Benign Schwannoma malady

Neuronal, Cancer categories

Summaries for Benign Schwannoma

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33MalaCards
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MalaCards: Benign Schwannoma, also known as neurilemmoma, is related to acoustic neuroma and adenoma. An important gene associated with Benign Schwannoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Hypertrophic cardiomyopathy (HCM). The compounds glycogen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and colon, and related mouse phenotypes are behavior/neurological and mortality/aging.

Aliases & Classifications for Benign Schwannoma

Sources:
49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
benign schwannoma:
Prevalence: 1-9/100000


Aliases & Descriptions:

benign schwannoma 49 61
neurilemmoma 49 61
peripheral fibroblastoma 49
neurolemmoma 49
neurilemoma 49


Related Diseases for Benign Schwannoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the adult malignant schwannoma family:

benign schwannoma

Diseases related to Benign Schwannoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma30.1NF1, NF2
2adenoma30.0ACTC1, CDH1
3spindle cell sarcoma29.9ACTC1, DES, S100B
4ganglioneuroma29.8S100B
5pleomorphic adenoma29.8S100B, DES, ACTC1
6neurofibromatosis29.8NF1, NF2
7n syndrome10.4
8sympathetic neurilemmoma10.3
9tarsal tunnel syndrome10.2
10plexiform schwannoma10.2
11neurilemmoma of the fifth cranial nerve10.2
12neurilemmomatosis10.2
13macrocystic neurilemmoma10.1
14neurilemmoma of the pleura10.1
15benign mediastinal psammomatous neurilemmoma10.1
16mediastinal melanocytic neurilemmoma10.1
17thoracic outlet syndrome10.1
18horner's syndrome10.1
19benign dermal neurilemmoma10.0
20cellular schwannoma10.0
21epidermolysis bullosa acquisita10.0
22carney complex10.0
23epithelioid malignant peripheral nerve sheath tumor10.0
24benign mediastinal neurilemmoma10.0
25benign peripheral nerve sheath tumor10.0
26rubinstein-taybi syndrome10.0
27xeroderma pigmentosum10.0
28osteomalacia10.0
29fasciitis10.0ACTC1
30perineurioma10.0S100B
31angiosarcoma10.0ACTC1
32teratoma10.0ACTC1
33papilloma10.0ACTC1
34syringoma10.0S100B
35lymphangioleiomyomatosis10.0DES
36infantile myofibromatosis10.0DES
37liposarcoma10.0DES
38benign mesothelioma10.0NF2
39endometrial carcinoma10.0CDH1
40ganglioglioma10.0S100B
41myoepithelioma10.0ACTC1, S100B
42fibrous meningioma10.0NF2, S100B
43pheochromocytoma10.0NF1
44glomus tumor10.0ACTC1, DES
45angiomyolipoma10.0ACTC1, DES
46fibromatosis10.0ACTC1, DES
47hemangioblastoma10.0S100B
48microphthalmia10.0ACTC1, S100B
49epithelioid leiomyosarcoma10.0ACTC1, DES
50anaplastic ependymoma10.0S100B, NF2

Graphical network of the top 20 diseases related to Benign Schwannoma:



Diseases related to benign schwannoma

Clinical Features for Benign Schwannoma

Drugs & Therapeutics for Benign Schwannoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Benign Schwannoma

Drug clinical trials:

Search ClinicalTrials for Benign Schwannoma

Search NIH Clinical Center for Benign Schwannoma

Search CenterWatch for Benign Schwannoma

Genetic Tests for Benign Schwannoma

Anatomical Context for Benign Schwannoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Benign Schwannoma:

33
Heart, Small intestine, Colon, Liver, Lung, Pancreas, Salivary gland, Breast, Tonsil, Tongue

Animal Models for Benign Schwannoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Benign Schwannoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.7NF1, NF2, DES, CTNNA2, S100B
2MP:00107686.9ACTC1, CTNNA2, DES, NF2, NF1, CDH1

Publications for Benign Schwannoma

Sources:
51PubMed
See all sources

Articles related to Benign Schwannoma:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Recurrent benign schwannoma of the scalp: Case report. (23123417)
2013
2
A case of giant, benign schwannoma associated with total lung collapse by bloody effusion. (24023560)
2013
3
Retroperitoneoscopic resection of a lower posterior mediastinal benign schwannoma using a transdiaphragmatic approach. (23652068)
2013
4
Mediastinal mass diagnosed as a benign schwannoma. (21947156)
2011
5
Pancreatic benign schwannoma: combined with hemorrhage in an internal cyst. (21401900)
2011
6
Benign schwannoma of the hepatoduodenal ligament. (21590600)
2011
7
A case report of benign schwannoma of the liver. (20686285)
2010
8
Benign schwannoma of the tonsil. (22767561)
2010
9
Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. (20934169)
2010
10
Concurrent benign schwannoma of oesophagus and posterior mediastinum. (19770133)
2009
11
Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties. (17705894)
2008
12
Retroperitoneal benign schwannoma in the suprapancreatic area. (18166471)
2008
13
Benign schwannoma of the liver: a case report. (18756066)
2008
14
Giant benign schwannoma on scalp causing 'double-head'. (18564825)
2008
15
Growth of benign and malignant schwannoma xenografts in severe combined immunodeficiency mice. (17075413)
2006
16
Benign hybrid perineurioma-schwannoma in the colon. A case report. (17126257)
2006
17
Benign schwannoma with perineurioma-like areas: A clinicopathologic study of 11 cases. (17041195)
2006
18
Pancreatic benign schwannoma treated by simple enucleation: case report and review of literature. (16163062)
2005
19
Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex. (12848884)
2003
20
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. (14762614)
2003
21
Retroperitoneal benign schwannoma: report of three cases and analysis of clinico-radiologic findings. (12962406)
2003
22
Primary benign schwannoma of the heart. (14507580)
2003
23
Endoscopic endonasal approach for the treatment of benign schwannoma of the sinonasal tract and pterygopalatine fossa. (12030357)
2002
24
Coexistence of benign schwannoma and lymphoma in a nasal polyp. (12437849)
2002
25
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. (11465777)
2001
26
Benign schwannoma in the porta hepatis. (11517064)
2001
27
Benign schwannoma. (10800357)
2000
28
Benign schwannoma of the obturator nerve: a case report. (9757997)
1998
29
Benign schwannoma simulating a ciliary body melanoma. (9614541)
1998
30
Case report: magnetic resonance imaging (MRI) appearances of benign schwannoma of the larynx. (9022589)
1997
31
Benign schwannoma of the small intestine: an unusual cause of gastrointestinal bleeding. (7636397)
1995
32
Benign schwannoma of the liver: a case report. (7575085)
1994
33
Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. (8095064)
1993
34
A case of benign schwannoma of the thoracic wall mimicking a malignant tumor. (8289436)
1993
35
Benign schwannoma in the hepatoduodenal ligament: report of a case. (7681709)
1993
36
Benign schwannoma of the retroperitoneal space: case report. (8510246)
1993
37
Benign schwannoma of the esophagus presenting as a giant fibrovascular polyp. (1731684)
1992
38
Benign schwannoma of the pancreas. (1503050)
1992
39
Benign schwannoma and parathyroid adenoma occurring in the nonradiated neck: report of two cases. (2325424)
1990
40
Pathologic quiz case 1. Benign schwannoma of the parapharyngeal space. (2306361)
1990
41
Solitary benign schwannoma in the psoas muscle. (2191923)
1990
42
Benign schwannoma of the foot. (2746488)
1989
43
Benign neurilemmoma (schwannoma) masquerading as a pleomorphic adenoma of the submandibular salivary gland. (2555990)
1989
44
Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study. (3126126)
1988
45
Malignant epithelioid peripheral nerve sheath tumor arising in a benign schwannoma. (3686324)
1987
46
Malignant epithelioid schwannoma arising in a benign schwannoma. A case report. (3995488)
1985
47
Benign schwannoma. Clinical and histopathologic findings. (4009467)
1985
48
Benign schwannoma involving the infratemporal fossa and orbit. (6823192)
1983
49
Recurrence of benign orbital neurilemmoma (schwannoma) after 22 years. (7165843)
1982
50
Benign schwannoma: demonstration of Verocay bodies using fine needle aspiration. (266346)
1977

Genetic Variations for Benign Schwannoma

Expression for genes affiliated with Benign Schwannoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Schwannoma

Search GEO for disease gene expression data for Benign Schwannoma.

Pathways for genes affiliated with Benign Schwannoma

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN
See all sources

Compounds for genes affiliated with Benign Schwannoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Benign Schwannoma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1glycogen45 2411.5ACTC1
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.7S100B, DES
3orcein459.6S100B, DES, ACTC1
4s 100459.6ACTC1, DES, S100B
5reticulin459.6S100B, DES, ACTC1
6mucicarmine459.5ACTC1, DES, S100B
7imatinib45 50 1111.5ACTC1, DES, S100B
8acetaldehyde45 29 2411.4DES, CDH1
9ccl445 2910.2DES, S100B
10iron45 2410.2ACTC1, DES, S100B
11proline459.0CDH1, DES, S100B
12b 723459.0S100B, DES, CDH1, ACTC1
13methionine458.9NF1, DES, S100B
14hematoxylin458.9ACTC1, CDH1, DES, S100B
15lactate458.9CDH1, DES, S100B
16formaldehyde45 249.9S100B, DES, CDH1, ACTC1
17cytochalasin d45 609.9NF2, NF1, CDH1
18creatinine458.9ACTC1, CDH1, DES, S100B
19testosterone45 60 11 2411.8S100B, DES, CDH1, ACTC1
20vegf458.8ACTC1, CDH1, DES, S100B
21rapamycin458.8CDH1, NF1, NF2
22steroid458.6ACTC1, NF1, DES, S100B
23fatty acid458.6S100B, DES, NF1
24adenylate458.4S100B, DES, NF1, CDH1
25cyclic amp45 249.4CDH1, NF1, DES, S100B
26arginine458.3S100B, DES, NF1, CDH1
27estrogen458.1ACTC1, CDH1, NF1, DES, S100B
28retinoic acid45 249.1S100B, DES, NF1, CDH1, ACTC1
29cysteine458.0S100B, DES, NF2, NF1, CDH1
30serine457.9S100B, DES, NF2, NF1, CDH1
31calcium45 50 11 2410.9ACTC1, CDH1, NF1, DES, S100B
32paraffin457.7ACTC1, CDH1, NF1, NF2, DES, S100B
33progesterone45 60 29 11 2411.7ACTC1, CDH1, NF1, NF2, DES, S100B
34tyrosine457.6ACTC1, CDH1, NF1, NF2, DES, S100B

GO Terms for genes affiliated with Benign Schwannoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:0059139.2CTNNA2, CDH1
2adherens junctionGO:0059129.2CTNNA2, NF2
3cytoplasmGO:0057377.3S100B, CTNNA2, NF2, NF1, CDH1, ACTC1

Biological processes related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5DES, ACTC1
2negative regulation of cell-cell adhesionGO:0224089.4CDH1, NF2
3cell-cell junction organizationGO:0452169.4CDH1, NF2
4negative regulation of cell-matrix adhesionGO:0019539.3NF1, NF2
5negative regulation of MAPK cascadeGO:0434099.3NF1, NF2
6negative regulation of protein kinase activityGO:0064698.9NF1, NF2

Molecular functions related to Benign Schwannoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletal protein bindingGO:0080929.5NF2, DES

Products for genes affiliated with Benign Schwannoma

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  • Proteins
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  • Antibodies

Sources for Benign Schwannoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet