Benign Tumors malady

MedlinePlus: Tumors are abnormal growths in your body. they are made up of extra cells. normally, old cells die, and new ones take their place. sometimes, however, this process goes wrong. new cells form even when you don't need them, and old cells don't die when they should. when these extra cells form a mass, it is called a tumor. tumors can be either benign or malignant. benign tumors aren't cancer. malignant ones are. benign tumors grow only in one place. they cannot spread or invade other parts of your body. even so, they can be dangerous if they press on vital organs, such as your brain. treatment often involves surgery. benign tumors usually don't grow back.²³

MalaCards: Benign Tumors, also known as benign neoplasm, is related to skin benign neoplasm and myoma. An important gene associated with Benign Tumors is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase), and among its related pathways are Renal cell carcinoma and Signal transduction_PTEN pathway. The compounds cyclophosphamide and b 723 have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lung, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: A benign tumor is a tumor that lacks the ability to metastasize. Common examples of benign tumors...⁴⁴ more...

benign tumors 17 23 benign neoplasm 43

benign tumor 32

Diseases related to benign tumors by text searches and GeneDecks gene sharing:

(show top 50)    (show all 850)

id	Related Disease	Score	Top Affiliating Genes
1	skin benign neoplasm	31.1	MMP13, FLCN, MAPK1, NF1, KRT13
2	myoma	30.6	PCNA, LEP, FH, GSR, ESR1, HMGA2
3	ovarian cancer	30.6	MUC16, SLC2A1, NME1, PGR
4	lipoma	30.0	VIM, CD34, FLCN, HMGA1, HMGA2, DUSP19
5	sertoli cell tumor	29.3	PCNA, VIM, MUC1, CGB5, DES, STK11
6	hepatic adenoma	29.1	PCNA, CD34, HNF1A, STK11
7	ossifying fibroma	29.0	VIM, MUC16, CD34, ACTC1, TSC1, DES
8	adrenal adenoma	29.0	CDKN1C, GNAS, PRKAR1A, PRL, GAST
9	glomus tumor	29.0	VIM, VHL, SDHB, MUC1, S100B, CD34
10	hereditary leiomyomatosis and renal cell cancer	28.7	SDHB, FH, HIF1A
11	adenofibroma	28.7	MUC16, PTEN, PGR
12	neurofibromatosis	28.7	VHL, SDHB, S100B, MMP13, NF1, NF2
13	breast cancer	28.5	VEGFA, MMP13, FLT1, ESR1, TP53, PTEN
14	pleomorphic adenoma	28.5	PCNA, VIM, MUC1, S100B, FGF1, HMGA1
15	angiomyolipoma	28.5	VIM, CHGA, MUC1, S100B, ESR1, TP53
16	thyroid adenoma	28.2	RASSF1, LGALS3, MUC1, GNAS, TPO, PTEN
17	follicular adenoma	28.2	LGALS3, MKI67, TPO, PTEN
18	choroid plexus papilloma	28.2	MUC1, S100B, GFAP
19	lung benign neoplasm	27.7	PIK3CG, RARB, RASSF1, CHGA, MVP, MST1R
20	hepatitis	27.7	GUSB, GSR, FAS, PDGFB, KRT8, AFP
21	squamous cell carcinoma	27.5	SERPINB3, LGALS3, MKI67, TP73, DAPK1, TOP1
22	prolactinoma	27.3	CHGA, FOS, MKI67, MAPK1, GNAS, ESR1
23	granular cell tumor	27.3	VIM, CHGA, S100B, MKI67, MBP, PTEN
24	parathyroid adenoma	27.1	PCNA, LGALS3, CHGA, MKI67, FLCN, GNAS
25	benign mesothelioma	27.1	VIM, TP53, NF2, DES
26	dermatofibrosarcoma protuberans	27.0	VIM, MUC1, S100B, CD34, MMP11, MMP14
27	dermatofibrosarcoma	27.0	VIM, MUC1, S100B, CD34, MMP11, MMP14
28	cushing's syndrome	26.8	LEP, CHGA, GNAS, PRKAR1A, PRL
29	tuberous sclerosis	26.6	PIK3CG, PCNA, VIM, VHL, VEGFA, MVP
30	neurofibroma	26.5	VIM, VEGFA, MUC1, S100B, CD34, MMP13
31	primary hyperparathyroidism	25.9	LEP, CHGA, GNAS, NF1, ABCB1, PRKAR1A
32	adrenocortical tumor	25.8	VHL, VEGFA, SDHB, CHGA, CDKN1C, MKI67
33	dna topoisomerase i	25.7	MKI67, HPSE, TP53, DUSP19, CTSL1, ABCB1
34	craniopharyngioma	25.4	PCNA, VIM, RARB, LGALS3, LEP, CD34
35	acromegaly	24.8	VEGFA, LEP, CHGA, GNAS, TP53, CTSD
36	leiomyoma	24.8	PCNA, SERPINB3, VIM, BSG, VEGFA, RAD51B
37	endometriosis	21.0	PCNA, SERPINB3, VIM, BSG, VEGFA, LEP
38	epithelial ovarian cancer	20.5	PIK3CG, VIM, BSG, VEGFA, RASSF1, LEP
39	thyroid carcinoma	18.8	PIK3CG, PCNA, SERPINB3, VIM, BSG, VHL
40	ovarian carcinoma	18.2	PIK3CG, PCNA, VIM, BSG, VHL, VEGFA
41	adenoma	16.5	PCNA, VIM, BSG, VHL, VEGFA, RARB
42	angiomatosis	14.1	VHL, CD34, PLAG1, TSC2
43	multiple endocrine neoplasia type 2a	14.0	VHL, NF1, ACTC1, TFF1
44	lymphangioleiomyomatosis	14.0	TSC1, TSC2, DES
45	adenomas, salivary gland pleomorphic	14.0	S100B, HMGA2, PLAG1
46	cowden disease	13.9	DUSP19, TEP1, PTEN, TSC1, TSC2, STK11
47	cystic kidney	13.9	VHL, FH, MAPK1, TSC1, TSC2
48	spindle cell lipoma	13.9	VIM, CD34, ACTC1, DES
49	malignant giant cell tumor of soft parts	13.9	S100B, ACTC1, DES
50	cutaneous fibrous histiocytoma	13.9	VIM, CD34, MMP11, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to benign tumors:

²²

MGI Mouse Phenotypes related to benign tumors:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	PRKAR1A, PDGFB, NF2, NF1, MN1
2	endocrine/exocrine gland phenotype	MP:0005379	10.1	GGT1, AFP, PRKAR1A, NF2, NF1, HMGA2
3	hematopoietic system phenotype	MP:0005397	9.8	PRKAR1A, CD34, MST1R, LGALS3, VHL, PCNA
4	renal/urinary system phenotype	MP:0005367	9.8	DAPK1, PTEN, ESR1, HNF1A, GNAS, MET
5	craniofacial phenotype	MP:0005382	9.7	CDKN1C, MN1, GUSB, GNAS, HMGA2, CSF1
6	embryogenesis phenotype	MP:0005380	9.4	TGFB3, KRT8, NF2, NF1, COPS5, PLAG1
7	other phenotype	MP:0005395	9.1	CSF1, ABCB1, NF1, CTSL1, CTSB, TP73
8	integument phenotype	MP:0010771	8.4	TERC, TP53, HMGA2, GNAS, FAS, GUSB
9	pigmentation phenotype	MP:0001186	8.3	NF1, GGT1, LEP, ITGB1, TP53, TERC
10	no phenotypic analysis	MP:0003012	8.1	MUC1, HMGA1, ESR1, PDGFB, HNF1A, GNAS
11	nervous system phenotype	MP:0003631	7.7	WNT5B, NME1, SLC2A1, CST3, CSF1, SOX2
12	liver/biliary system phenotype	MP:0005370	7.6	SOD1, VEGFA, VHL, MET, CCNG1, PRL
13	hearing/vestibular/ear phenotype	MP:0005377	7.6	MBP, FAS, GUSB, FOS, ITGB1, GPX1
14	limbs/digits/tail phenotype	MP:0005371	7.6	GNAS, FAS, MET, GUSB, MMP14, MMP13
15	normal phenotype	MP:0002873	7.3	HAS2, PGR, SOX2, PRKAR1A, PSCA, STK11
16	reproductive system phenotype	MP:0005389	7.1	STK11, TSC1, KRT8, SKP2, PDGFB, NF2
17	immune system phenotype	MP:0005387	7.0	GGT1, CTSB, CTSD, TERT, TERC, TP53
18	digestive/alimentary phenotype	MP:0005381	6.9	SOX2, PRKAR1A, STK11, TFF1, TGFB3, GFAP
19	tumorigenesis	MP:0002006	6.8	TSC1, HIF1A, NF2, NF1, PLAU, SMARCB1
20	skeleton phenotype	MP:0005390	6.7	TP73, LGALS3, RARB, VEGFA, VHL, PIK3CG
21	behavior/neurological phenotype	MP:0005386	6.4	MMP14, ITGB1, MN1, CDKN1C, S100B, LEP
22	muscle phenotype	MP:0005369	6.3	VHL, VIM, PIK3CG, HAS2, PGR, CST3
23	growth/size phenotype	MP:0005378	5.9	GGT1, HAS2, SLC2A1, SOX2, PRKAR1A, STK11
24	vision/eye phenotype	MP:0005391	5.2	GFAP, TP53, GPX1, MAL, MBP, FAS
25	cardiovascular system phenotype	MP:0005385	4.3	MET, RARB, VEGFA, VHL, VIM, PIK3CG
26	mortality/aging	MP:0010768	4.1	TSC2, PTEN, TPO, TP73, TP53, CAT
27	cellular phenotype	MP:0005384	3.7	FOS, PIK3CG, PCNA, VIM, MMP14, MMP13
28	homeostasis/metabolism phenotype	MP:0005376	1.5	ITGB1, PIK3CG, VIM, MN1, CDKN1C, CD34

Articles related to benign tumors:

(show all 27)

id	Title	Authors	Year	Affiliating Genes
1	Expression of FK506 binding protein 65 (FKBP65) is de creased in epithelial ovarian cancer cells compared to benign tumor cells and t o ovarian epithelium. (21399973)	Henriksen R.... Birkenkamp-Demtroder K.	2011	FKBP10
2	Large cell calcifying Sertoli cell tumor: a clinicopa thologic study of 1 malignant and 3 benign tumors using histomorphology, immuno histochemistry, ultrastructure, comparative genomic hybridization, and polymera se chain reaction analysis of the PRKAR1A gene. (20004940)	Petersson F.... Hes O.	2010	PRKAR1A
3	Detection of tolerance against human chorionic gonado tropin at malignant and benign tumors of female reproduction system. (19578206)	Akhvlediani L.... Dumbadze G.	2009	CGB5
4	Serum sFas, leptin, and VEGF in patients with ovarian cancer and benign tumors. (20396799)	Vysotskii M.M.... Manukhin I.B.	2009	VEGFA, FAS, LEP
5	Expression pattern of MAL in normal epithelial cells , benign tumor, and squamous cell carcinoma of larynx]. (19670627)	Jiang Y.... Alonso M.A.	2009	MAL
6	Comparative evaluation of plasma levels and diagnosti c values of macrophage-colony stimulating factor in patients with breast cancer and benign tumors. (18846980)	A8awicki S.... Szmitkowski M.	2008	CSF1
7	Papillary glioneuronal tumor: not always a benign tumor? (19157003)	Adam C.... Gray F.	2007	GFAP
8	Elevation of CA 19-9 and chromogranin A, in addition to CA 125, are detectable in benign tumors in leiomyomas and endometriosis. (17506483)	Tsao K.C.... Wu J.T.	2007	CHGA, AFP, SERPINB3
9	Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets. (15983380)	Comtesse N.... Meese E.	2005	SOX2, RRP36
10	Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor. (15972578)	Mangioni S.... Di Blasio A.M.	2005	WNT5B
11	Metastasis of benign tumor cells in tuberous sclerosis complex. (14566858)	Henske E.P.	2003	TSC1, TSC2
12	Expression P53 protein and chromosome aberrations in benign tumors and ovarian carcinoma (14674118)	KamiA8ski K.... Oleszczuk J.	2003	TP53
13	Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg- Dube syndrome. (12204536)	Nickerson M.L.... Schmidt L.S.	2002	FLCN
14	Activity of glutathione-metabolizing and antioxidant enzymes in malignant and benign tumors of human lungs. (12447480)	Korotkina R.N.... Karelin A.A.	2002	SOD1, GSR, CAT
15	Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. (10767330)	Rutkowski J.L.... Legius E.	2000	NF1
16	A novel high mobility group protein gene is a candidate for Xp22 abnormalities in uterine leiomyomas and other benign tumors. (11063803)	Blank C.... Bullerdiek J.	2000	HMGA1P1
17	Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors. (10074910)	Kyo S.... Inoue M.	1999	TERC
18	Duodenum-preserving resection of the pancreas head in treatment of benign tumors of the pancreas head (9676366)	Schoenberg M.H.... Beger H.G.	1998	GAST
19	Chromosomal translocations in benign tumors: the HMGI proteins. (9495195)	Hess J.L.	1998	HMGA1, HMGA2
20	Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. (9351565)	Kratzer S.S.... Young R.H.	1997	PCNA
21	v-sis oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumors. (7955050)	Yang D.... McCormick J.J.	1994	PDGFB
22	Enzyme-linked immunosorbent assay of pS2 in breast cancers, benign tumors, and normal breast tissues. Correlation with prognosis and adjuvant hormone therapy. (1544118)	Predine J.... Milgrom E.	1992	TFF1
23	Sialyl-Tn, sialyl-Lewis Xi, CA 19-9, CA 125, carcinoembryonic antigen, and tissue polypeptide antigen in differentiating ovarian cancer from benign tumors. (1346716)	Inoue M.... Tanizawa O.	1992	PSG2
24	P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy. (1682037)	Van der Zee A.G.... de Vries E.G.	1991	ABCB1, TOP1
25	Granular cell tumor. Immunohistochemical analysis of 21 benign tumors and one malignant tumor. (1694654)	Mazur M.T.... Myers J.L.	1990	MBP
26	The hormonal status and steroid receptor system of the endometrium in patients with benign tumors and endometrioid cysts of the ovaries (2278311)	Adamian L.V.... Novikov E.A.	1990	PGR, PRL
27	Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. (2456993)	Guelstein V.I.... Bannikov G.A.	1988	KRT8

Genes related to benign tumors according to GeneCards:

(show top 50)    (show all 112)

id	Symbol	Description	Score	GeneCards Section Context
1	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Summaries
2	PLAG1	pleiomorphic adenoma gene 1	11.0	Expressions
3	FLCN	folliculin	11.0	Publications
4	PSCA	prostate stem cell antigen	11.0
5	CCNG1	cyclin G1	11.0
6	KRT13	keratin 13	11.0
7	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0
8	MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	11.0
9	MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	11.0
10	HMGA1	high mobility group AT-hook 1	11.0	Publications
11	FH	fumarate hydratase	11.0
12	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
13	TFF1	trefoil factor 1	11.0	Publications
14	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0
15	TERC	telomerase RNA component	11.0	Publications
16	TEP1	telomerase-associated protein 1	11.0
17	TSC1	tuberous sclerosis 1	11.0	Publications
18	PRDM2	PR domain containing 2, with ZNF domain	11.0
19	HPSE	heparanase	11.0
20	HMGA2	high mobility group AT-hook 2	11.0	Publications
21	TSC2	tuberous sclerosis 2	11.0	Publications
22	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
23	TGFB3	transforming growth factor, beta 3	11.0
24	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0
25	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0
26	STK11	serine/threonine kinase 11	11.0
27	TOP2A	topoisomerase (DNA) II alpha 170kDa	11.0
28	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0
29	NF2	neurofibromin 2 (merlin)	11.0
30	MVP	major vault protein	11.0
31	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0
32	ACTC1	actin, alpha, cardiac muscle 1	11.0
33	COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	11.0
34	CTSL1	cathepsin L1	11.0
35	DUSP19	dual specificity phosphatase 19	11.0
36	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0
37	CD34	CD34 molecule	11.0
38	PGR	progesterone receptor	11.0	Publications
39	PLAU	plasminogen activator, urokinase	11.0
40	MUC1	mucin 1, cell surface associated	11.0
41	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0
42	PTEN	phosphatase and tensin homolog	11.0
43	FGF1	fibroblast growth factor 1 (acidic)	11.0
44	MKI67	antigen identified by monoclonal antibody Ki-67	11.0
45	RAD51B	RAD51 homolog B (S. cerevisiae)	11.0
46	MAPK3	mitogen-activated protein kinase 3	11.0
47	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0
48	MUC16	mucin 16, cell surface associated	11.0
49	NF1	neurofibromin 1	11.0	Publications
50	CTSD	cathepsin D	11.0

Pathways related to benign tumors according to GeneDecks:

(show top 50)    (show all 103)

id	Pathway	Score	Top Affiliating Genes
1	Renal cell carcinoma20	10.7	PDGFB, TGFB3, MET, HIF1A, FH, VHL
2	Signal transduction_PTEN pathway41	10.7	ITGB1, PCNA, TSC2
3	Breast Cancer Regulation by Stathmin136	10.6	MST1R, FGF1, CCNG1, TGFB3, PDGFB, NUDT6
4	14-3-3 Induced Intracellular Signaling36	10.5	TSC2, TSC1, PDGFB, TP73, MAPK3, MST1R
5	Signal transduction PTEN pathway10	10.5	TSC2, PCNA, ITGB1, MAPK3, MAPK1, PTEN
6	Transcription Receptor-mediated HIF regulation10	10.5	HIF1A, MAPK1, MAPK3, TSC2
7	Glioma Invasiveness36	10.5	NUDT6, ITGB1, FGF1, PLAU, PLAUR, TGFB3
8	Cell adhesion PLAU signaling10	10.5	PLAUR, PLAU, MET, ITGB1
9	mTOR Pathway36	10.5	PDGFB, NUDT6, STK11, TGFB3, TSC2, TSC1
10	Angiogenesis3	10.5	FGF1, MST1R, ITGB1, FLT1, TGFB3, HIF1A
11	Akt Signaling36	10.4	PIK3CG, TSC1, PDGFB, NUDT6, MET, FGF1
12	PPAR Pathway36	10.4	FLT1, FGF1, NUDT6, TGFB3, MAPK1, MET
13	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.4	MAPK3, LEP
14	Cell adhesion_PLAU signaling41	10.3	ITGB1, PLAUR, PLAU, MAPK1, MAPK3, MET
15	Development VEGF-family signaling10	10.3	FLT1, MAPK3, MAPK1, ITGB1, FOS
16	Ras Pathway36	10.3	TGFB3, MET, PDGFB, MAPK1, MAPK3, NUDT6
17	Nanog in Mammalian ESC Pluripotency36	10.2	MAPK3, WNT5B, MST1R, FLT1, FGF1, MET
18	Non-small cell lung cancer20	10.2	RASSF1, PIK3CG, MAPK1
19	Focal adhesion20	10.2	PDGFB, COL1A2, PTEN, PIK3CG, ITGB1, FLT1
20	UPA-UPAR Pathway36	10.2	MAPK1, MMP13, FOS, MMP11, ITGB1, COL1A2
21	Glioblastoma Multiforme36	10.1	PDGFB, NF1, PTEN, TSC2, TP53, MAPK1
22	ILK Signaling36	10.1	NUDT6, VIM, MAPK1, MAPK3, MET, FGF1
23	Estrogen Pathway36	10.1	FOS, FLT1, PDGFB, NUDT6, PRKAR1A, TGFB3
24	Signal transduction_AKT signaling41	10.1	HSP90AA1, MET, PCNA, TSC2, TP53, TSC1
25	Development HGF signaling pathway10	10.1	FAS, MAPK3, MAPK1, PLAU, MET, FOS
26	Melanoma20	10.1	MAPK1, PIK3CG, FGF1, MET, MAPK3, TP53
27	ERK Signaling36	10.1	COL1A2, MST1R, ITGB1, FLT1, MAPK3, MAPK1
28	Telomerase Components in Cell Signaling36	10.0	PDGFB, FLT1, TERT, TEP1, TP53, HSP90AA1
29	GPCR Pathway36	10.0	PRKAR1A, TGFB3, PDGFB, MAPK1, MAPK3, MET
30	HIF1Alpha Pathway36	9.9	SLC2A1, HIF1A, COPS5, TP53, HSP90AA1, MAPK1
31	Pancreatic Adenocarcinoma36	9.9	CCNG1, MAPK1, MET, FGF1, FLT1, MMP13
32	Renin-Angiotensin Pathway36	9.9	FLT1, FGF1, MET, MAPK3, MAPK1, NUDT6
33	Development_HGF signaling pathway41	9.9	MAPK1, MAPK3, FAS, MET, FOS, PLAU
34	Development VEGF signaling and activation10	9.9	FOS, MAPK3, MAPK1, NF1
35	Oxidative Stress Pathway (Erythrocyte)34	9.8	SOD1, GSR, GPX1, CAT
36	Pathway_PA16598033734	9.8	CAT, GPX1, GSR, SOD1
37	Oxidative Stress Pathway (Erythrocyte)34	9.8	SOD1, CAT, GSR, GPX1
38	PTEN Pathway36	9.8	FLT1, FGF1, MET, MAPK1, TP53, PTEN
39	mTOR signaling pathway20	9.8	HIF1A, TSC1, TSC2, STK11, MAPK1, MAPK3
40	Transcription_Receptor-mediated HIF regulation41	9.6	HIF1A, VEGFA, MAPK3, PTEN, MAPK1, TSC2
41	Development_VEGF signaling via VEGFR2 - generic cascades41	9.6	VEGFA, MAPK3, HSPB1, MAPK1, PLAUR, NF1
42	Prostate cancer20	9.6	PDGFB, TP53, HSP90AA1, MAPK3, MAPK1, PIK3CG
43	Rho Family GTPases36	9.6	PDGFB, COL1A2, FGF1, MAPK3, FLT1, ITGB1
44	Molecular Mechanisms of Cancer36	9.5	MET, FGF1, TGFB3, SOX2, NUDT6, TSC2
45	Development_VEGF-family signaling41	9.4	ITGB1, FOS, FLT1, VEGFA, MAPK3, MAPK1
46	MAPK Signaling36	9.4	PRKAR1A, TP53, MAPK1, MAPK3, MET, FGF1
47	Development_VEGF signaling and activation41	9.3	FOS, VEGFA, MAPK3, MAPK1, ESR1, NF1
48	Bladder cancer20	9.2	MAPK1, DAPK1, TP53, MAPK3, RASSF1, VEGFA
49	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.0	TOP2A, CAT, ABCB1, TP53, SOD1, GPX1
50	Pathways in cancer20	8.2	HIF1A, PTEN, DAPK1, SKP2, TGFB3, SLC2A1

Compounds related to benign tumors according to GeneDecks:

(show top 50)    (show all 373)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.9	MVP
2	b 72332	10.0	PCNA, VIM, CHGA, MUC1, MUC16, S100B
3	trastuzumab32 34 9 9	12.9	PIK3CG, MUC1, FAS, MAPK1, HSP90AA1, PTEN
4	egcg32	9.8	PIK3CG, MAPK3, CAT, TOP1, SOD1
5	dmso32	9.7	VIM, SDHB, CHGA, CGB5, TP73, DUSP19
6	dopamine32 9 18 9	12.4	RARB, SDHB, S100B, CGB5, FOS, GUSB
7	tgf beta132	9.4	MMP13, MMP14, MKI67, FLT1, FGF1, FAS
8	hematoxylin32	9.3	PCNA, VIM, LGALS3, CHGA, MUC1, MUC16
9	ascorbic acid32 18	10.3	PIK3CG, PCNA, SDHB, S100B, CGB5, MMP13
10	12-o-tetradecanoylphorbol 13-acetate32	9.3	RARB, CD34, ITGB1, MMP11, MMP13, MMP14
11	rapamycin32 42	10.2	PIK3CG, VIM, VHL, VEGFA, FLT1, FLCN
12	h2o232	9.2	PIK3CG, SDHB, LGALS3, LEP, MUC16, CGB5
13	glycogen32 18	10.1	PIK3CG, VIM, VHL, SDHB, LGALS3, CHGA
14	p00232	9.0	LEP, CHGA, MVP, MMP13, MMP14, MKI67
15	progestin32	8.9	VIM, VEGFA, CGB5, CTSD, PLAU, DES
16	heparin32 9 18 9	11.8	PIK3CG, VIM, BSG, LGALS3, ITGB1, MMP13
17	pge232	8.8	CGB5, MMP13, GSR, FGF1, GNAS, HSP90AA1
18	ly29400232	8.7	PIK3CG, VHL, VEGFA, LEP, MMP14, FOS
19	cysteine32	8.7	PCNA, RARB, SDHB, LGALS3, MUC1, S100B
20	aspartate32	8.5	PCNA, VIM, SDHB, S100B, GUSB, FH
21	glutamate32	8.4	PCNA, VIM, BSG, SDHB, LGALS3, LEP
22	oxygen32 18	9.4	SDHB, LGALS3, CGB5, ITGB1, MMP11, MMP13
23	cyclosporin a32 42	9.4	PIK3CG, BSG, SDHB, LEP, MVP, S100B
24	formaldehyde32 18	9.3	PCNA, VIM, LGALS3, CHGA, MUC1, S100B
25	atp32	8.2	SDHB, LGALS3, MVP, CGB5, ITGB1, FH
26	ribonucleic acid32	8.2	RARB, CHGA, MUC1, CGB5, MMP13, MMP14
27	alanine32	8.2	PCNA, RASSF1, LGALS3, S100B, MMP14, GSTA1
28	progesterone32 42 9 18 9	12.1	PCNA, BSG, RARB, CHGA, MVP, MUC16
29	oligonucleotide32	8.0	PCNA, VIM, VHL, RARB, RASSF1, LGALS3
30	resveratrol32 9 18 9	10.8	PIK3CG, PCNA, BSG, VEGFA, GUSB, FAS
31	epinephrine32 9 18 9	10.7	SDHB, LEP, CHGA, MVP, CGB5, GSR
32	matrigel32	7.7	PIK3CG, VIM, BSG, VEGFA, LGALS3, CHGA
33	phosphatidylinositol32	7.6	PIK3CG, VHL, LGALS3, LEP, MST1R, ITGB1
34	glutamine32	7.6	PIK3CG, PCNA, VIM, LGALS3, S100B, ITGB1
35	adenylate32	7.3	PIK3CG, VIM, RARB, CHGA, S100B, CGB5
36	etoposide32 42 9 9	10.3	PIK3CG, PCNA, LGALS3, CHGA, MVP, S100B
37	forskolin32 42 9 9	10.2	VIM, RARB, CHGA, MUC1, S100B, CGB5
38	adriamycin32	7.2	VIM, MVP, MUC1, GSR, MET, FAS
39	vegf32	7.0	PIK3CG, PCNA, BSG, VHL, SDHB, LGALS3
40	5fluorouracil32	6.8	PIK3CG, PCNA, VEGFA, MVP, MUC1, MKI67
41	arginine32	6.6	RARB, SDHB, LEP, CHGA, S100B, CGB5
42	testosterone32 9 18 9	9.2	PCNA, VIM, RARB, SDHB, LEP, CHGA
43	indomethacin32 9 9	8.1	PCNA, VIM, LEP, CGB5, MMP13, GSR
44	doxorubicin32 34 9 9	8.4	PIK3CG, VIM, VEGFA, MVP, MUC16, CGB5
45	paclitaxel32 34 9 9	8.3	PIK3CG, PCNA, VIM, VEGFA, CHGA, MVP
46	dexamethasone32 42 34 9 9	8.8	PCNA, VIM, VEGFA, RARB, LEP, CHGA
47	tyrosine32	4.7	PIK3CG, BSG, VHL, VEGFA, RARB, SDHB
48	cycloheximide32	4.7	PIK3CG, VIM, VEGFA, RARB, LEP, CHGA
49	serine32	4.5	PIK3CG, SERPINB3, VIM, BSG, VHL, RASSF1
50	cisplatin32 34 9 9	6.9	PCNA, VEGFA, RARB, RASSF1, LGALS3, LEP

Cellular components related to benign tumors according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:042470	10.0	BSG, ITGB1, MMP14, SLC2A1, CTSB, CTSD
2	nuclear chromosome	GO:000228	10.0	HMGA2, TOP2A, TOP1, SMARCB1
3	nucleoplasm	GO:005654	8.6	TERT, TP53, HMGA1, ESR1, MAPK1, MAPK3
4	cell surface	GO:009986	8.4	ABCB1, VEGFA, ITGB1, HSPB1, TPO, PLAU
5	extracellular space	GO:005615	7.5	CTSD, AFP, LEP, VEGFA, MUC16, MMP13
6	nucleus	GO:005634	7.3	FLT1, SOX2, PCNA, HSPB1, HPSE, HNF1A
7	cytosol	GO:005829	7.0	SOD1, SOX2, TSC1, PRKAR1A, NME1, GPX1
8	extracellular region	GO:005576	6.6	FAS, FGF1, HPSE, GNAS, MMP13, MMP11
9	cytoplasm	GO:005737	6.0	SOX2, PTEN, TERT, TEP1, TPO, MVP
10	plasma membrane	GO:005886	5.9	ABCB1, TPO, TGFB3, PSCA, SOD1, CSF1

Biological processes related to benign tumors according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:010629	10.3	PGR, PLAG1, PLAUR, ESR1, CD34
2	activation of MAPK activity	GO:000187	10.1	MET, MAPK3, MAPK1, TGFB3, TP73, SOD1
3	response to wounding	GO:009611	10.1	MET, CTSB, PDGFB, SOX2, GFAP
4	extracellular matrix organization	GO:030198	10.0	LGALS3, MMP11, MMP13, MMP14, COL1A2, GFAP
5	negative regulation of cell proliferation	GO:008285	10.0	TSC1, VHL, RARB, CDKN1C, ITGB1, HMGA1
6	cell cycle arrest	GO:007050	10.0	TSC1, TP73, SOX2, TSC2, STK11, RASSF1
7	negative regulation of protein kinase activity	GO:006469	10.0	NF1, TSC2, NF2, HSPB1, DUSP19
8	heart contraction	GO:060047	10.0	GPX1, ACTC1, SOD1
9	positive regulation of MAPK cascade	GO:043410	10.0	FLT1, DUSP19, SOX2, PDGFB, ITGB1, LEP
10	innate immune response	GO:045087	9.9	CSF1, CTSL1, CTSB, MAPK1, LGALS3, S100B
11	positive regulation of MAP kinase activity	GO:043406	9.8	PDGFB, FLT1, MST1R, VEGFA, PIK3CG
12	female pregnancy	GO:007565	9.7	LEP, PSG2, FLT1, GNAS, TGFB3, PRL
13	positive regulation of transcription, DNA-dependent	GO:045893	9.7	CDKN1C, FOS, HMGA1, TP53, TP73, PDGFB
14	glutathione metabolic process	GO:006749	9.6	GSR, GSTA1, GGT1, GPX1, SOD1
15	positive regulation of gene expression	GO:010628	9.6	PLAUR, CD34, HMGA2, VEGFA, CSF1, PLAG1
16	anti-apoptosis	GO:006916	9.6	DAPK1, SOD1, VHL, TERT, HSPB1, GPX1
17	positive regulation of cell division	GO:051781	9.5	VEGFA, TGFB3, PDGFB, CAT, FGF1
18	positive regulation of cell migration	GO:030335	9.4	FLT1, MMP14, VEGFA, FGF1, PDGFB, CSF1
19	cell proliferation	GO:008283	9.3	MET, TP53, PTEN, SKP2, PRL, CSF1
20	regulation of blood pressure	GO:008217	9.2	SOD1, COL1A2, CD34, CHGA, LEP
21	response to drug	GO:042493	9.0	PDGFB, ITGB1, MET, FAS, ACTC1, MVP
22	positive regulation of apoptotic process	GO:043065	8.8	ITGB1, HMGA2, KNG1, NF1, FAS, RARB
23	platelet activation	GO:030168	8.8	MAPK1, PDGFB, PIK3CG, VEGFA, KNG1, MAPK3
24	positive regulation of cell proliferation	GO:008284	8.7	MST1R, PTEN, PDGFB, HAS2, CSF1, FGF1
25	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	HMGA2, TP73, SMARCB1, TP53, HNF1A, MAPK3
26	response to hypoxia	GO:001666	8.6	TGFB3, PDGFB, HIF1A, NF1, CAT, FAS
27	negative regulation of apoptotic process	GO:043066	8.5	PTEN, TP53, HMGA2, CAT, PLAUR, HSPB1
28	small molecule metabolic process	GO:044281	8.2	GGT1, NME1, SLC2A1, GPX1, BSG, GNAS
29	blood coagulation	GO:007596	7.8	SOD1, PRKAR1A, TGFB3, PDGFB, COL1A2, PLAUR

Molecular functions related to benign tumors according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	9.3	PTEN, VHL, MST1R, ESR1, CAT, HMGA1
2	growth factor activity	GO:008083	8.8	VEGFA, LEP, FGF1, PDGFB, TGFB3, TFF1
3	identical protein binding	GO:042802	8.7	VIM, S100B, FLT1, FAS, HSP90AA1, ESR1
4	protein heterodimerization activity	GO:046982	8.5	VEGFA, ITGB1, MET, TP53, PDGFB, HIF1A
5	protein homodimerization activity	GO:042803	8.2	TSC2, S100B, GSR, HSP90AA1, SOD1, CAT
6	protein binding	GO:005515	3.9	GGT1, PDGFB, NF2, NF1, COPS5, COL1A2