MCID: BRB001
MIFTS: 40

Beriberi malady

Metabolic category

Summaries for Beriberi

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Beriberi refers to a cluster of symptoms caused primarily by a nutritional deficit in Vitamin B1... more...

MalaCards: Beriberi, also known as thiamine deficiency, is related to wernicke-korsakoff syndrome and wernicke encephalopathy. An important gene associated with Beriberi is DPYS (dihydropyrimidinase). The drugs thiamine and thiamine mononitrate and the compounds thymine and pyrimidine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart.

Aliases & Classifications for Beriberi

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

beriberi 8 43 10 45 61
thiamine deficiency 43 45 61
vitamin b1 deficiency 43


External Ids:

Disease Ontology8 DOID:13725
MeSH35 D001602
NCIt40 C34418
ICD9CM27 265.0
ICD1025 E51, E51.1, E51.9

Related Diseases for Beriberi

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Beriberi:



Diseases related to beriberi

Clinical Features for Beriberi

Drugs & Therapeutics for Beriberi

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Beriberi

Drug clinical trials:

Search ClinicalTrials for Beriberi

Search NIH Clinical Center for Beriberi

Search CenterWatch for Beriberi

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Beriberi

Anatomical Context for Beriberi

Sources:
33MalaCards
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MalaCards organs/tissues related to Beriberi:

33
Liver, Brain, Heart, Endothelial

Animal Models for Beriberi or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Beriberi

Sources:
51PubMed
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Articles related to Beriberi:

(show top 50)    (show all 245)
idTitleAuthorsYear
1
Acute dilated cardiomyopathy in a patient with beriberi and cryoglobulinaemic vasculitis: an unusual potential complication of two rare disorders. (24429381)
2014
2
Kanehiro Takaki and the control of beriberi in the Japanese Navy. (23897451)
2013
3
Case of beriberi showing improved cerebral blood flow after thiamine treatment. (22998382)
2012
4
Beriberi disease: is it still present in the United States? (22800868)
2012
5
Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency. (22136604)
2012
6
Outbreak of beriberi in the state of MaranhALo, Brazil: revisiting the mycotoxin aetiologic hypothesis. (20305104)
2010
7
Severe anasarca due to beriberi heart disease and diabetic nephropathy. (19459028)
2009
8
Pediatric cardiac beriberi: 3 different presentations. (19253515)
2008
9
Beriberi epidemic in MaranhALo State, Brazil]. (18545746)
2008
10
ST-segment elevation of electrocardiogram in a patient with Shoshin beriberi. (16020883)
2005
11
Histopathological changes of biopsied myocardium in Shoshin beriberi. (16157967)
2005
12
The rise of scientific medicine in Japan: Beriberi as the driving force in the quest for specific causes and the introduction of bacteriology. (15212048)
2004
13
Shoshin beriberi with vasospastic angina pectoris possible mechanism of mid-ventricular obstruction: possible mechanism of mid-ventricular obstruction. (12419944)
2002
14
Early recognition of acute cardiovascular beriberi by interpretation of hemodynamics. (11377164)
2001
15
Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage. (9417174)
1998
16
TPN-induced fulminant beriberi: a report on our experience and a review of the literature. (8897674)
1996
17
Bontius and Tulp on beriberi polyneuropathy. (8201344)
1994
18
Beriberi cardiomyopathy. (1313764)
1992
19
Neuropathic beriberi and carbamazepine. (2844112)
1988
20
The search for the cause of beriberi in the Malay Peninsula: the contribution of Dr. W. L. Braddon. (11617395)
1988
21
Beriberi heart disease in Durban. A retrospective study. (3616806)
1987
22
Beriberi can complicate TPN. (3114687)
1987
23
Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. (3921738)
1985
24
Shoshin beriberi: a rare diagnostic problem. (6508970)
1984
25
Thiamine-dependent beriberi in the "thiamine-responsive anemia syndrome". (6472386)
1984
26
Fulminant cardiac beriberi with severe acidosis. (7175406)
1982
27
The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: substrate beriberi. (7062860)
1982
28
Dry beriberi: a clinical report from north-west Ethiopia. (520297)
1979
29
Malaria and beriberi: unresolved military medical problems contributing to the fall of Cambodia. (107479)
1979
30
Beriberi heart disease. (4260190)
1972
31
Tropical malnutrition. 1. Food requirements and nutritional syndromes; beriberi. (5905851)
1966
32
Experimental studies on the beriberi heart. II. Effect of starvation and role of vagus nerve. (14009299)
1962
33
Beriberi heart disease in the elderly patient. (14400982)
1960
34
Fulminating beriberi. (13515212)
1958
35
Beriberi heart disease. (13368221)
1956
36
POLYNEURITIS beriberi due to a deficiency of vitamin B1. (14371243)
1955
37
Beriberi heart disease. (13097096)
1953
38
The world beriberi problem today. (13130700)
1953
39
Condition of the heart following beriberi and malnutrition. (14914214)
1952
40
A case of acute beriberi complicating polyserositis in Britain. (14896122)
1952
41
Cardiac beriberi simulating arteriosclerotic heart disease. (14885076)
1951
42
Infantile beriberi; human milk intoxication due to B avitaminosis. (14869053)
1951
43
Artificial enrichment of white rice as a solution to endemic beriberi; report of field trials in Bataan, Philippines. (14804156)
1950
44
Studies on beriberi in an endemic sub-tropical area. (18892936)
1948
45
A fatal case of beriberi in a child in England. (20994689)
1946
46
Beriberi; etiological and clinical considerations. (20282927)
1946
47
THE EFFECT OF COCARBOXYLASE UPON METABOLISM AND NEURO-PSYCHIATRIC PHENOMENA IN PELLAGRINS WITH BERIBERI. (17829078)
1939
48
The pre-Beriberi Condition: With special reference to its existence in Japan. (20474966)
1928
49
A Note on the Temporary Spontaneous Disappearance of Typical "Beriberi" Symptoms in Pigeons Fed on Diets Deficient in Vitamin B. (16743906)
1927
50
Glyoxalase in Avian Beriberi. (16742958)
1921

Genetic Variations for Beriberi

Expression for genes affiliated with Beriberi

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Beriberi

Search GEO for disease gene expression data for Beriberi.

Pathways for genes affiliated with Beriberi

Compounds for genes affiliated with Beriberi

Sources:
45Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Beriberi according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1thymine45 2410.3TKT, DPYS
2pyrimidine45 2410.3TKT, DPYS
3thiamin diphosphate459.2TKT, TPK1
4thiamine monophosphate45 2410.2TKT, TPK1
5alpha-ketoglutarate459.1TKT, TPK1
6cytosine45 2410.1DPYS, TKT
7pyruvate459.0TPK1, TKT
8thiamine pyrophosphate45 249.7TPK1, TKT, HACL1
9thiamine45 2 11 2411.7TPK1, TKT, HACL1
10magnesium45 11 2410.5TPK1, TKT, HACL1
11atp45 299.2TPK1, TKT, FHL1

GO Terms for genes affiliated with Beriberi

Sources:
16Gene Ontology
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Cellular components related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057778.8TKT, HACL1
2cytosolGO:0058298.1TPK1, TKT, DPYS, FHL1

Biological processes related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1TPK1, TKT, DPYS, HACL1

Molecular functions related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cofactor bindingGO:0480379.1TKT, HACL1

Products for genes affiliated with Beriberi

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Beriberi

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet