MCID: BRB001
MIFTS: 43

Beriberi malady

Metabolic diseases category

Summaries for Beriberi

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63Wikipedia, 32MalaCards
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Wikipedia:63 Beriberi refers to a cluster of symptoms caused primarily by a nutritional deficit in Vitamin B1... more...

MalaCards: Beriberi, also known as thiamine deficiency, is related to wernicke-korsakoff syndrome and polyneuropathy. An important gene associated with Beriberi is DPYS (dihydropyrimidinase). The drugs thiamine and thiamine mononitrate and the compounds thymine and pyrimidine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver.

Aliases & Classifications for Beriberi

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

beriberi 8 42 10 44 60
thiamine deficiency 42 44 60
vitamin b1 deficiency 42


External Ids:

Disease Ontology8 DOID:13725
MeSH34 D001602
NCIt39 C34418
ICD9CM27 265.0
ICD1025 E51, E51.1, E51.9

Related Diseases for Beriberi

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Beriberi:



Diseases related to beriberi

Clinical Features for Beriberi

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Drugs & Therapeutics for Beriberi

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Beriberi

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Beriberi

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Anatomical Context for Beriberi

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32MalaCards
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MalaCards organs/tissues related to Beriberi:

32
Heart, Brain, Liver, Endothelial

Animal Models for Beriberi or affiliated genes

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Publications for Beriberi

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Sources:
50PubMed
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Articles related to Beriberi:

(show top 50)    (show all 243)
idTitleAuthorsYear
1
Clinical correlates and outcome of shoshin beriberi. (23112976)
2012
2
Beriberi disease: is it still present in the United States? (22800868)
2012
3
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. (21364976)
2011
4
Shoshin beriberi mimicking a high-risk non-ST-segment elevation acute coronary syndrome with cardiogenic shock: when the arteries are not guilty. (18930369)
2011
5
A retrospective investigation of thiamin and energy intakes following an outbreak of beriberi in The Gambia. (22254079)
2011
6
Thiamine deficiency and beriberi features in a patient with hyperemesis gravidarum. (15979284)
2005
7
Gastrointestinal beriberi: a previously unrecognized syndrome. (15583247)
2004
8
The rise of scientific medicine in Japan: Beriberi as the driving force in the quest for specific causes and the introduction of bacteriology. (15212048)
2004
9
Shoshin beriberi with vasospastic angina pectoris possible mechanism of mid-ventricular obstruction: possible mechanism of mid-ventricular obstruction. (12419944)
2002
10
Early recognition of acute cardiovascular beriberi by interpretation of hemodynamics. (11377164)
2001
11
Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage. (9417174)
1998
12
A case of beriberi accompanying short bowel. (7754775)
1995
13
Electrophysiologic examination of subclinical beriberi polyneuropathy. (8549435)
1995
14
Shoshin beriberi in an infant of a thiamine-deficient mother. (1421919)
1992
15
Clinical diagnosis of cardiac beriberi. (2305319)
1990
16
Beriberi heart disease in Durban. A retrospective study. (3616806)
1987
17
Myocardial function in alcoholic cardiac beriberi. (3679603)
1987
18
Infantile beriberi presenting as subacute necrotizing encephalomyelopathy. (3585605)
1987
19
Acute pernicious or fulminating beriberi with severe lactic acidosis. A case report. (4071332)
1985
20
Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. (3921738)
1985
21
Beriberi and mycotoxicosis: an historical account. (6400045)
1984
22
The beriberi analogy to myocardial infarction. (6341793)
1983
23
Shoshin beriberi. (6123912)
1982
24
The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: substrate beriberi. (7062860)
1982
25
Blood vitamin B1, transketolase and thiamine pyrophosphate (TPP) effect in beriberi patients, with studies employing discriminant analysis. (7449142)
1980
26
Chronic cardiac beriberi in a former prisoner of the Japanese. (7437412)
1980
27
Dry beriberi: a clinical report from north-west Ethiopia. (520297)
1979
28
Malaria and beriberi: unresolved military medical problems contributing to the fall of Cambodia. (107479)
1979
29
Giant T inversion in cardiac beriberi. (1206261)
1975
30
Wet beriberi in an alcoholic. (1139239)
1975
31
Nutrition classics from The Archives of Internal Medicine 45:1-22, 1930. The beriberi heart. Chester S. Keefer. (4606854)
1974
32
Cardiac beriberi: two modes of presentation. (5571454)
1971
33
Persistence of low cardiac output after relief of high output by thiamine in a case of alcoholic beriberi and cardiac myopathy. (5426825)
1970
34
Blood transketolase activity in beriberi heart disease. A useful diagnostic index. (5694078)
1968
35
Tropical malnutrition. 1. Food requirements and nutritional syndromes; beriberi. (5905851)
1966
36
Beriberi heart disease in the elderly patient. (14400982)
1960
37
Beriberi heart disease. (13629790)
1959
38
Physiological studies on beriberi heart disease by injection of radioactive material. (13618804)
1959
39
Beriberi. (13586354)
1958
40
Prolonged myocardial disease due to beriberi, with necropsy after 18 years. (13458097)
1957
41
POLYNEURITIS beriberi due to a deficiency of vitamin B1. (14371243)
1955
42
Physiologic observations on a case of beriberi heart disease, with a note on the acute effects of thiamine. (13016605)
1953
43
A case of acute beriberi complicating polyserositis in Britain. (14896122)
1952
44
The most typical symptom of infantile beriberi; preliminary report. (14922405)
1951
45
Beriberi and pyruvic acid. (14922407)
1951
46
Cardiovascular beriberi. (14868379)
1951
47
Artificial enrichment of white rice as a solution to endemic beriberi; report of field trials in Bataan, Philippines. (14804156)
1950
48
Cardiovascular manifestations of beriberi based on a study of ten patients. (15391541)
1949
49
A fatal case of beriberi in a child in England. (20994689)
1946
50
The pre-Beriberi Condition: With special reference to its existence in Japan. (20474966)
1928

Genetic Variations for Beriberi

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Expression for genes affiliated with Beriberi

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Beriberi

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Pathways for genes affiliated with Beriberi

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Compounds for genes affiliated with Beriberi

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 28IUPHAR
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Compounds related to Beriberi according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1thymine44 2410.3TKT, DPYS
2pyrimidine44 2410.3TKT, DPYS
3thiamin diphosphate449.2TKT, TPK1
4thiamine monophosphate44 2410.2TKT, TPK1
5alpha-ketoglutarate449.1TKT, TPK1
6cytosine44 2410.1DPYS, TKT
7pyruvate449.0TPK1, TKT
8thiamine pyrophosphate44 249.7TPK1, TKT, HACL1
9thiamine44 2 11 2411.7TPK1, TKT, HACL1
10magnesium44 11 2410.5TPK1, TKT, HACL1
11atp44 289.2TPK1, TKT, FHL1

GO Terms for genes affiliated with Beriberi

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16Gene Ontology
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Cellular components related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057778.8TKT, HACL1
2cytosolGO:0058298.1TPK1, TKT, DPYS, FHL1

Biological processes related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1TPK1, TKT, DPYS, HACL1

Molecular functions related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cofactor bindingGO:0480379.1TKT, HACL1

Products for genes affiliated with Beriberi

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Beriberi

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet