MCID: BRB001
MIFTS: 42

Beriberi malady

Rare diseases category
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Summaries for Beriberi

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65Wikipedia, 33MalaCards
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Wikipedia:65 \"Beri Beri\" redirects here. For the African ethnic group, please see Kanuri people more...

MalaCards: Beriberi, also known as thiamine deficiency, is related to wernicke-korsakoff syndrome and polyneuropathy. An important gene associated with Beriberi is TKT (transketolase), and among its related pathways is Metabolism. The drugs thiamine and thiamine mononitrate and the compounds thymine and pyrimidine have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain.

Aliases & Classifications for Beriberi

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

beriberi 8 43 10 45 62
thiamine deficiency 43 45 62
vitamin b1 deficiency 43


External Ids:

Disease Ontology8 DOID:13725
MeSH35 D001602
NCIt40 C34418
ICD9CM27 265.0
ICD1025 E51, E51.1, E51.9

Related Diseases for Beriberi

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Beriberi:



Diseases related to beriberi

Symptoms for Beriberi

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Drugs & Therapeutics for Beriberi

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Beriberi

Search NIH Clinical Center for Beriberi

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Beriberi

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Anatomical Context for Beriberi

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33MalaCards
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MalaCards organs/tissues related to Beriberi:

33
Heart, Liver, Brain, Endothelial

Animal Models for Beriberi or affiliated genes

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Publications for Beriberi

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Sources:
52PubMed
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Articles related to Beriberi:

(show top 50)    (show all 241)
idTitleAuthorsYear
1
Use of central venous saturation monitoring in a patient with pediatric cardiac beriberi. (24303502)
2013
2
Adolphe Vorderman's 1897 study on beriberi: an example of scrupulous efforts to avoid bias. (23481433)
2013
3
Case of beriberi showing improved cerebral blood flow after thiamine treatment. (22998382)
2012
4
Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi? (21941485)
2011
5
Outbreak of beriberi in the state of MaranhALo, Brazil: revisiting the mycotoxin aetiologic hypothesis. (20305104)
2010
6
Rapidly progressive polyneuropathy due to dry beriberi in a man: a case report. (21176139)
2010
7
Outbreak of beriberi in a prison in CA'te d'Ivoire. (17974361)
2007
8
The great disease enemy, Kak'ke (beriberi) and the Imperial Japanese Army. (16673750)
2006
9
Gastrointestinal beriberi: a previously unrecognized syndrome. (15583247)
2004
10
Postgastrectomy polyneuropathy with thiamine deficiency is identical to beriberi neuropathy. (15561484)
2004
11
Outbreak of beriberi among illegal mainland Chinese immigrants at a detention center in Taiwan. (12604765)
2003
12
Shoshin beriberi with vasospastic angina pectoris possible mechanism of mid-ventricular obstruction: possible mechanism of mid-ventricular obstruction. (12419944)
2002
13
Early recognition of acute cardiovascular beriberi by interpretation of hemodynamics. (11377164)
2001
14
Experimentally induced beriberi polyneuropathy in chickens. (7737017)
1995
15
A case of beriberi accompanying short bowel. (7754775)
1995
16
Cardiac beriberi (shoshin beriberi) caused by excessive intake of isotonic drink. (1414337)
1992
17
Shoshin beriberi in an infant of a thiamine-deficient mother. (1421919)
1992
18
Clinical diagnosis of cardiac beriberi. (2305319)
1990
19
Beriberi secondary to tooth decay. (2567829)
1989
20
Beriberi--another Asia-Pacific connection. (3052543)
1988
21
Neuropathic beriberi and carbamazepine. (2844112)
1988
22
Shoshin beriberi: an underdiagnosed condition? (3771918)
1986
23
Thiamine-dependent beriberi. (3969105)
1985
24
Shoshin beriberi: a rare diagnostic problem. (6508970)
1984
25
The beriberi analogy to myocardial infarction. (6341793)
1983
26
Shoshin beriberi. (6952848)
1982
27
Shoshin beriberi. (6123912)
1982
28
Alcoholic cardiac beriberi. (6807459)
1982
29
A protection against beriberi. (7357326)
1980
30
Swellengrebel lecture. Beriberi. (7210153)
1980
31
Atrophic beriberi. A complication of jejunoileal bypass surgery for morbid obesity. (210663)
1978
32
A possible case of beriberi heart failure in a chronic hemodialyzed patient. (124021)
1975
33
Cardiac beriberi: two modes of presentation. (5571454)
1971
34
Persistence of low cardiac output after relief of high output by thiamine in a case of alcoholic beriberi and cardiac myopathy. (5426825)
1970
35
Blood transketolase activity in beriberi heart disease. A useful diagnostic index. (5694078)
1968
36
Therapeutic use of vitamin B1 in diseases other than beriberi. (14009959)
1962
37
Beriberi heart disease in the elderly patient. (14400982)
1960
38
Beriberi heart disease. (13524621)
1958
39
John Blackall's observations on the relation between nutritional deprivation and wet beriberi. (13348836)
1956
40
POLYNEURITIS beriberi due to a deficiency of vitamin B1. (14371243)
1955
41
Beriberi heart disease. (13097096)
1953
42
The world beriberi problem today. (13130700)
1953
43
Cardiac beriberi simulating arteriosclerotic heart disease. (14885076)
1951
44
Artificial enrichment of white rice as a solution to endemic beriberi; preliminary report of field trials. (18140048)
1949
45
Cardiovascular manifestations of beriberi based on a study of ten patients. (15391541)
1949
46
Beriberi heart disease. (21017512)
1946
47
THE EFFECT OF COCARBOXYLASE UPON METABOLISM AND NEURO-PSYCHIATRIC PHENOMENA IN PELLAGRINS WITH BERIBERI. (17829078)
1939
48
Beriberi and other Food-deficiency Diseases in New-foundland and Labrador. (20475070)
1930
49
Studies on beriberi: VIII. The relationship of beriberi to glands of internal secretion. (16993223)
1914
50
UNCURED RICE AS A CAUSE OF BERIBERI. (20764688)
1909

Variations for Beriberi

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Expression for genes affiliated with Beriberi

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Beriberi

Search GEO for disease gene expression data for Beriberi.

Pathways for genes affiliated with Beriberi

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50PathCards, 55Reactome, 30KEGG
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Pathways related to Beriberi according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.0TKT, DPYS, TPK1, HACL1

Compounds for genes affiliated with Beriberi

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Sources:
45Novoseek, 24HMDB, 3BitterDB, 11DrugBank
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Compounds related to Beriberi according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1thymine45 2410.5TKT, DPYS
2pyrimidine45 2410.4TKT, DPYS
3thiamine monophosphate45 2410.4TPK1, TKT
4cytosine45 2410.3DPYS, TKT
5thiamin diphosphate459.3TPK1, TKT
6thymidine45 2410.3TKT, DPYS
7alpha-ketoglutarate459.2TKT, TPK1
8pyruvate459.0TKT, TPK1
95fluorouracil459.0TKT, DPYS
10thiamine pyrophosphate45 249.9TKT, TPK1, HACL1
11thiamine45 3 24 1111.8TKT, TPK1, HACL1
12magnesium45 24 1110.8HACL1, TPK1, TKT

GO Terms for genes affiliated with Beriberi

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16Gene Ontology
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Cellular components related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.1TKT, HACL1
2cytosolGO:0058298.5TKT, DPYS, TPK1

Biological processes related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.0TKT, DPYS, TPK1, HACL1

Molecular functions related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cofactor bindingGO:0480379.4TKT, HACL1

Products for genes affiliated with Beriberi

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Beriberi

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet