MCID: BRB001
MIFTS: 36

Beriberi

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Beriberi

MalaCards integrated aliases for Beriberi:

Name: Beriberi 12 50 52 42 14 69
Thiamine Deficiency 50 52 69
Vitamin B1 Deficiency 50

Classifications:



External Ids:

Disease Ontology 12 DOID:13725
ICD9CM 35 265.0
MeSH 42 D001602
NCIt 47 C34418
UMLS 69 C0005122

Summaries for Beriberi

NIH Rare Diseases : 50 beriberi is a condition that occurs in people who are deficient in thiamine (vitamin b1). there are two major types of beriberi: wet beriberi which affects the cardiovascular system and dry beriberi which affects the nervous system. people with wet beriberi may experience increased heart rate, shortness of breath, and swelling of the lower legs. signs and symptoms of dry beriberi include difficulty walking; loss of feeling in the hands and/or feet; paralysis of the lower legs; mental confusion; speech difficulty; pain; and/or vomiting. beriberi is rare in the united states since many foods are now vitamin enriched; however, alcohol abuse, dialysis and taking high doses of diuretics increases the risk of developing the condition. in most cases, beriberi occurs sporadically in people with no family history of the condition. a rare condition known as genetic beriberi is inherited (passed down through families) and is associated with an inability to absorb thiamine from foods. treatment generally includes thiamine supplementation, given by injection or taken by mouth. last updated: 11/17/2015

MalaCards based summary : Beriberi, also known as thiamine deficiency, is related to cerebral beriberi and wernicke-korsakoff syndrome. An important gene associated with Beriberi is TKT (Transketolase), and among its related pathways/superpathways is Vitamin digestion and absorption. The drugs Folic Acid and Thiamine have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and liver, and related phenotype is behavior/neurological.

Wikipedia : 72 Beriberi refers to symptoms caused by thiamine (vitamin B1) deficiency. Beriberi has conventionally been... more...

Related Diseases for Beriberi

Diseases related to Beriberi via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 cerebral beriberi 11.9
2 wernicke-korsakoff syndrome 11.2
3 heart disease 10.4
4 encephalopathy 10.1
5 polyneuropathy 10.1
6 neuropathy 10.0
7 lactic acidosis 10.0
8 cardiomyopathy 10.0
9 cardiogenic shock 9.8
10 cerebritis 9.8
11 pulmonary hypertension 9.8
12 metabolic acidosis 9.8
13 guillain-barre syndrome 9.8
14 angina pectoris 9.6
15 myopathy 9.6
16 dilated cardiomyopathy 9.6
17 vasculitis 9.6
18 morbid obesity 9.6
19 eating disorder 9.6
20 jejunoileitis 9.6
21 short bowel syndrome 9.6
22 endotheliitis 9.6
23 pericardial effusion 9.6
24 schizophrenia 9.6
25 critical illness polyneuropathy 9.6
26 myocardial infarction 9.6
27 wernicke encephalopathy 9.6
28 malaria 9.6
29 purpura 9.6
30 obesity 9.6
31 specific language impairment 5 9.5 SLC19A2 SLC19A3
32 siberian tick typhus 9.3 SLC19A2 TKT
33 malignant secondary hypertension 7.4 EPHA3 HACL1 SLC19A2 SLC19A3 TKT TRPV3

Graphical network of the top 20 diseases related to Beriberi:



Diseases related to Beriberi

Symptoms & Phenotypes for Beriberi

MGI Mouse Phenotypes related to Beriberi:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 EPHA3 SLC19A2 SLC19A3 TKT TRPV3

Drugs & Therapeutics for Beriberi

Drugs for Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
2
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-43-8 1130
3 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2
4 Trace Elements Phase 4,Phase 3,Phase 1,Phase 2
5 Vitamin B Complex Phase 4,Phase 3,Phase 1,Phase 2
6 Vitamins Phase 4,Phase 3,Phase 1,Phase 2
7 Folate Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
8 Thiamin Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
9 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
10 pyruvate Nutraceutical Phase 2
11
Iron Approved Phase 1 7439-89-6 23925

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
2 Prevention of Renal Complications of Diabetes With Thiamine Unknown status NCT01725412 Phase 4
3 A Trial of Thiamin Supplementation in Patients With Heart Failure Completed NCT00959075 Phase 4
4 Thiamin Deficiency in Obese Thai Children Recruiting NCT02464865 Phase 4 Thiamine 1;Thiamine 2
5 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
6 Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial Not yet recruiting NCT03228030 Phase 3
7 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2 D5W;Thiamine
8 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Recruiting NCT02974257 Phase 2 Thiamine
9 High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation Not yet recruiting NCT03263442 Phase 2 Thiamine;Normal saline
10 Thiamin Fortified Fish Sauce as a Means of Combating Infantile Beriberi in Rural Cambodia Completed NCT02221063 Phase 1
11 Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants Completed NCT01864057 Phase 1 thiamine hydrochloride 100 mg
12 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1 Thiamine;Placebos
13 Study of Dry Beriberi in Mayotte, Comoro Archipelago Unknown status NCT00934349
14 Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients Unknown status NCT02164487
15 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207
16 The Prevalence of Thiamin Deficiency in Ambulatory Patients With Heart Failure Completed NCT00953823
17 Thiamine Supplement in Patients With Severe Hyperthyroidism Completed NCT02767245 Thiamine

Search NIH Clinical Center for Beriberi

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: beriberi

Genetic Tests for Beriberi

Anatomical Context for Beriberi

MalaCards organs/tissues related to Beriberi:

39
Heart, Endothelial, Liver, Brain

Publications for Beriberi

Articles related to Beriberi:

(show top 50) (show all 268)
id Title Authors Year
1
Acute beriberi neuropathy mimicking Guillain-BarrAc syndrome after a strict vegetarian diet. ( 28761634 )
2017
2
Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern India. ( 28228301 )
2017
3
Acute Abdominal Pain as a Presenting Symptom of Beriberi in a Pediatric Patient. ( 27329387 )
2016
4
An unusual case of cardiogenic shock in which thiamine administration led to reversal of lactic acidosis and heart function recovery: Shoshin beriberi in an adolescent. ( 27505323 )
2016
5
Cranial Ultrasonography in Infantile Encephalitic Beriberi: A Useful First-Line Imaging Tool for Screening and Diagnosis in Suspected Cases. ( 27056426 )
2016
6
Case report: pericardial effusion with constrictive physiology in a patient with wet beriberi. ( 27059308 )
2016
7
Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation. ( 28050289 )
2016
8
Elevated Lactate Secondary to Gastrointestinal Beriberi. ( 25876741 )
2015
9
Beriberi (thiamine deficiency) and high infant mortality in northern laos. ( 25781926 )
2015
10
Wernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar. ( 26697247 )
2015
11
Beriberi in Cambodia. ( 25837026 )
2015
12
Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration. ( 26346515 )
2015
13
Dry beriberi preceded Wernicke's encephalopathy: Thiamine deficiency after laparoscopic sleeve gastrectomy. ( 26557183 )
2015
14
High-Output Heart Failure Caused by Thyrotoxicosis and Beriberi. ( 26567494 )
2015
15
Shoshin Beriberi in Critically-Ill patients: case series. ( 25982313 )
2015
16
Infantile encephalitic beriberi: magnetic resonance imaging findings. ( 26286085 )
2015
17
Beriberi: an uncommon complication of Sleeve gastrectomy. ( 26499354 )
2015
18
Beriberi in Cambodia. ( 26744150 )
2015
19
Christmas Island over 100 years: from beriberi to nutritional deficiencies of a different kind. ( 24890491 )
2014
20
Total parenteral nutrition caused Wernicke's encephalopathy accompanied by wet beriberi. ( 24516692 )
2014
21
Analysis of thiamine transporter genes in sporadic beriberi. ( 24607307 )
2014
22
Acute dilated cardiomyopathy in a patient with beriberi and cryoglobulinaemic vasculitis: an unusual potential complication of two rare disorders. ( 24429381 )
2014
23
Beriberi, a severe complication after metabolic surgery - review of the literature. ( 25095897 )
2014
24
Clinical history and colliquative myocytolysis are keys to the diagnosis of shoshin beriberi. ( 24891966 )
2014
25
Shoshin beriberi induced by long-term administration of diuretics: a case report. ( 25105030 )
2014
26
A case of shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after a single dose of thiamine. ( 25625639 )
2014
27
Thiamine deficiency, beriberi, and maternal and child health: why pharmacokinetics matter. ( 23902781 )
2013
28
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
29
A case of Shoshin Beriberi: lessons old and new for the psychiatrist. ( 22658327 )
2013
30
Use of central venous saturation monitoring in a patient with pediatric cardiac beriberi. ( 24303502 )
2013
31
Inducible intrapulmonary arteriovenous shunt in a patient with beriberi heart. ( 23378443 )
2013
32
Altered and unstable: wet beriberi, a clinical review. ( 23849362 )
2013
33
Kanehiro Takaki and the control of beriberi in the Japanese Navy. ( 23897451 )
2013
34
A case of cardiac beriberi: a forgotten but memorable disease. ( 24044018 )
2013
35
An eating disorder leading to wet beriberi heart failure in a 30-year-old woman. ( 23158607 )
2013
36
Adolphe Vorderman's 1897 study on beriberi: an example of scrupulous efforts to avoid bias. ( 23481433 )
2013
37
Beriberi in a dialysis patient: do we need more thiamine? ( 23399344 )
2013
38
Case of beriberi showing improved cerebral blood flow after thiamine treatment. ( 22998382 )
2012
39
Subacute myeloa89optic neuropathy, beriberi, and HTLVa89Ia89associated myelopathy: elucidation of some neurological diseases in Japan. ( 23222550 )
2012
40
Clinical correlates and outcome of shoshin beriberi. ( 23112976 )
2012
41
Thiamine deficiency in Cambodian infants with and without beriberi. ( 22703952 )
2012
42
Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery. ( 22525460 )
2012
43
Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency. ( 22136604 )
2012
44
Increase of serum vascular endothelial growth factors in wet beriberi: two case reports. ( 22504253 )
2012
45
Beriberi disease: is it still present in the United States? ( 22800868 )
2012
46
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. ( 21364976 )
2011
47
Outbreak of beriberi among African Union troops in Mogadishu, Somalia. ( 22205947 )
2011
48
Cardiac beriberi: morphological findings in two fatal cases. ( 21244717 )
2011
49
A retrospective investigation of thiamin and energy intakes following an outbreak of beriberi in The Gambia. ( 22254079 )
2011
50
Cardiovascular magnetic resonance in wet beriberi. ( 21838901 )
2011

Variations for Beriberi

Expression for Beriberi

Search GEO for disease gene expression data for Beriberi.

Pathways for Beriberi

Pathways related to Beriberi according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10 SLC19A2 SLC19A3

GO Terms for Beriberi

Cellular components related to Beriberi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 HACL1 TKT

Biological processes related to Beriberi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 thiamine-containing compound metabolic process GO:0042723 9.16 SLC19A2 SLC19A3
2 thiamine transmembrane transport GO:0071934 8.96 SLC19A2 SLC19A3
3 thiamine transport GO:0015888 8.62 SLC19A2 SLC19A3

Molecular functions related to Beriberi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.16 HACL1 TKT
2 thiamine transmembrane transporter activity GO:0015234 8.96 SLC19A2 SLC19A3
3 thiamine uptake transmembrane transporter activity GO:0015403 8.62 SLC19A2 SLC19A3

Sources for Beriberi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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