MCID: BRB001
MIFTS: 43

Beriberi malady

Metabolic diseases category

Summaries for Beriberi

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63Wikipedia, 32MalaCards
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Wikipedia:63 Beriberi refers to a cluster of symptoms caused primarily by a nutritional deficit in Vitamin B1... more...

MalaCards: Beriberi, also known as thiamine deficiency, is related to wernicke-korsakoff syndrome and polyneuropathy. An important gene associated with Beriberi is DPYS (dihydropyrimidinase). The drugs thiamine and thiamine mononitrate and the compounds thymine and pyrimidine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver.

Aliases & Classifications for Beriberi

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

beriberi 8 42 10 44 60
thiamine deficiency 42 44 60
vitamin b1 deficiency 42


External Ids:

Disease Ontology8 DOID:13725
MeSH34 D001602
NCIt39 C34418
ICD9CM27 265.0
ICD1025 E51, E51.1, E51.9

Related Diseases for Beriberi

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Beriberi:



Diseases related to beriberi

Clinical Features for Beriberi

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Drugs & Therapeutics for Beriberi

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Beriberi

Drug clinical trials:

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Search NIH Clinical Center for Beriberi

Search CenterWatch for Beriberi

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Beriberi

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Anatomical Context for Beriberi

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Sources:
32MalaCards
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MalaCards organs/tissues related to Beriberi:

32
Heart, Brain, Liver, Endothelial

Animal Models for Beriberi or affiliated genes

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Publications for Beriberi

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Sources:
50PubMed
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Articles related to Beriberi:

(show top 50)    (show all 243)
idTitleAuthorsYear
1
An eating disorder leading to wet beriberi heart failure in a 30-year-old woman. (23158607)
2013
2
A case of Shoshin Beriberi: lessons old and new for the psychiatrist. (22658327)
2013
3
A case of cardiac beriberi: a forgotten but memorable disease. (24044018)
2013
4
Case of beriberi showing improved cerebral blood flow after thiamine treatment. (22998382)
2012
5
Increase of serum vascular endothelial growth factors in wet beriberi: two case reports. (22504253)
2012
6
Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery. (22525460)
2012
7
Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi? (21941485)
2011
8
Shoshin beriberi mimicking central line sepsis in a child with short bowel syndrome. (20127217)
2010
9
British India and the "beriberi problem", 1798-1942. (20592882)
2010
10
Dry beriberi mimicking the Guillain-Barre syndrome. (19608771)
2009
11
Rapidly developing weakness mimicking Guillain-BarrAc syndrome in beriberi neuropathy: two case reports. (18440777)
2008
12
The skinny on a growing problem: dry beriberi after bariatric surgery. (19047041)
2008
13
Loop diuretic precipitated beriberi in a patient after pancreaticoduodenectomy: a case report. (18004099)
2007
14
The great disease enemy, Kak'ke (beriberi) and the Imperial Japanese Army. (16673750)
2006
15
Iatrogenic infantile beriberi. (17151409)
2006
16
Increased troponin I in "wet" beriberi. (16644891)
2006
17
Postgastrectomy polyneuropathy with thiamine deficiency is identical to beriberi neuropathy. (15561484)
2004
18
Occidental beriberi and sudden death. (15166742)
2004
19
Outbreak of beriberi among illegal mainland Chinese immigrants at a detention center in Taiwan. (12604765)
2003
20
Gene-environment interactions in wet beriberi: effects of thiamine depletion in CD36-defect rats. (12969879)
2003
21
Dietary and socio-economic factors associated with beriberi in breastfed Lao infants. (14567833)
2003
22
Cerebral beriberi (Wernicke's encephalopathy). (9678741)
1998
23
Beriberi unexpected. (9136259)
1997
24
Subclinical beriberi polyneuropathy in the low income group: an investigation with special tools on possible patients with suspected complaints. (8863016)
1996
25
Experimentally induced beriberi polyneuropathy in chickens. (7737017)
1995
26
Beriberi, vitamin B1 and world food policy, 1925-1970. (7877405)
1995
27
Acute pernicious or fulminating beriberi heart disease. A report of 6 patients. (7783822)
1995
28
Beriberi heart disease in a schizophrenic with an unusual diet. (2096166)
1990
29
Beriberi secondary to tooth decay. (2567829)
1989
30
Shoshin beriberi: an unusual complication of prolonged parenteral nutrition. (3080618)
1986
31
Thiamine-dependent beriberi. (3969105)
1985
32
Shoshin beriberi: report of two successfully treated patients with hemodynamic documentation. (6720597)
1984
33
A protection against beriberi. (7357326)
1980
34
Beriberi neuropathy. Morphometric study of sural nerve. (7365498)
1980
35
Beriberi. (824828)
1976
36
Axonal degeneration in beriberi neuropathy. (187157)
1976
37
Clinical and biochemical studies of adult beriberi. (5504957)
1970
38
Beriberi heart disease in London. (5822083)
1969
39
Hemodynamic studies in beriberi heart disease. (5912298)
1966
40
Therapeutic use of vitamin B1 in diseases other than beriberi. (14009959)
1962
41
Infantile beriberi associated with Wernicke's encephalopathy. (13542085)
1958
42
Recollections of the beriberi-preventing substance. (13087883)
1953
43
Beriberi heart disease. (13080162)
1953
44
Cardiac beriberi simulating arteriosclerotic heart disease. (14885076)
1951
45
Observations on beriberi heart disease. (20262638)
1947
46
Description of an outbreak of beriberi; with special reference to the aetiology of beriberi and epidemic dropsy. (20988937)
1946
47
BERIBERI heart failure. (20985914)
1946
48
Beriberi and other Food-deficiency Diseases in New-foundland and Labrador. (20475070)
1930
49
THREE CASES OF BERIBERI. (18737310)
1917
50
CONTRIBUTION TO THE STUDY OF BERIBERI. (19599698)
1911

Genetic Variations for Beriberi

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Expression for genes affiliated with Beriberi

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Beriberi

Search GEO for disease gene expression data for Beriberi.

Pathways for genes affiliated with Beriberi

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Compounds for genes affiliated with Beriberi

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Sources:
44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 28IUPHAR
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Compounds related to Beriberi according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1thymine44 2410.3DPYS, TKT
2pyrimidine44 2410.3TKT, DPYS
3thiamin diphosphate449.2TPK1, TKT
4thiamine monophosphate44 2410.2TPK1, TKT
5alpha-ketoglutarate449.1TKT, TPK1
6cytosine44 2410.1TKT, DPYS
7pyruvate449.0TKT, TPK1
8thiamine pyrophosphate44 249.7TPK1, TKT, HACL1
9thiamine44 2 11 2411.7HACL1, TPK1, TKT
10magnesium44 11 2410.5TKT, HACL1, TPK1
11atp44 289.2FHL1, TPK1, TKT

GO Terms for genes affiliated with Beriberi

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16Gene Ontology
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Cellular components related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057778.8TKT, HACL1
2cytosolGO:0058298.1TPK1, TKT, DPYS, FHL1

Biological processes related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442818.1TPK1, TKT, DPYS, HACL1

Molecular functions related to Beriberi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cofactor bindingGO:0480379.1TKT, HACL1

Products for genes affiliated with Beriberi

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Beriberi

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet