MCID: BRB001
MIFTS: 41

Beriberi malady

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Beriberi

Aliases & Descriptions for Beriberi:

Name: Beriberi 12 50 52 42 14 69
Thiamine Deficiency 50 52 69
Vitamin B1 Deficiency 50

Classifications:



External Ids:

Disease Ontology 12 DOID:13725
ICD9CM 35 265.0
MeSH 42 D001602
NCIt 47 C34418
UMLS 69 C0005122

Summaries for Beriberi

NIH Rare Diseases : 50 beriberi is a condition that occurs in people who are deficient in thiamine (vitamin b1). there are two major types of beriberi: wet beriberi which affects the cardiovascular system and dry beriberi which affects the nervous system. people with wet beriberi may experience increased heart rate, shortness of breath, and swelling of the lower legs. signs and symptoms of dry beriberi include difficulty walking; loss of feeling in the hands and/or feet; paralysis of the lower legs; mental confusion; speech difficulty; pain; and/or vomiting. beriberi is rare in the united states since many foods are now vitamin enriched; however, alcohol abuse, dialysis and taking high doses of diuretics increases the risk of developing the condition. in most cases, beriberi occurs sporadically in people with no family history of the condition. a rare condition known as genetic beriberi is inherited (passed down through families) and is associated with an inability to absorb thiamine from foods. treatment generally includes thiamine supplementation, given by injection or taken by mouth. last updated: 11/17/2015

MalaCards based summary : Beriberi, also known as thiamine deficiency, is related to cerebral beriberi and wernicke-korsakoff syndrome. An important gene associated with Beriberi is TKT (Transketolase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Vitamin digestion and absorption. The drugs Zinc and Copper have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and liver, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Beriberi refers to a cluster of symptoms caused primarily by thiamine (vitamin B1) deficiency. Beriberi... more...

Related Diseases for Beriberi

Graphical network of the top 20 diseases related to Beriberi:



Diseases related to Beriberi

Symptoms & Phenotypes for Beriberi

GenomeRNAi Phenotypes related to Beriberi according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.29 KALRN EPHA3
2 Decreased viability GR00107-A-1 10.29 TPK1
3 Decreased viability GR00173-A 10.29 TPK1
4 Decreased viability GR00221-A-1 10.29 KALRN
5 Decreased viability GR00221-A-2 10.29 KALRN
6 Decreased viability GR00221-A-3 10.29 TPK1
7 Decreased viability GR00221-A-4 10.29 KALRN TPK1 EPHA3
8 Decreased viability GR00240-S-1 10.29 TPK1
9 Decreased viability GR00301-A 10.29 KALRN EPHA3
10 Decreased viability GR00342-S-1 10.29 KALRN TPK1 EPHA3
11 Decreased viability GR00342-S-2 10.29 KALRN TPK1
12 Decreased viability GR00342-S-3 10.29 KALRN TPK1
13 Decreased viability GR00381-A-1 10.29 TPK1 KALRN
14 Decreased substrate adherent cell growth GR00193-A-2 8.96 EPHA3 KALRN

MGI Mouse Phenotypes related to Beriberi:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 EPHA3 KALRN SLC19A2 SLC19A3 TKT

Drugs & Therapeutics for Beriberi

Drugs for Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
2
Copper Approved Phase 4,Phase 3,Phase 2 15158-11-9, 7440-50-8 27099
3
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
4
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
5
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
6
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
7
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 65-23-6 1054
8
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
9
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
10
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
11
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 83-88-5 493570
12
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-81-7 5785 54670067
13
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936
14
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-43-8 1130
15
Pyridoxal Approved, Nutraceutical Phase 4,Phase 3,Phase 2 66-72-8 1050
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
17
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 68-19-9 44176380
18
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
19
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
20
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
21 vitamin d Phase 4,Phase 3,Phase 2
22
Iodine Phase 4,Phase 3,Phase 2 7553-56-2 807
23 Nicotinic Acids Phase 4,Phase 3,Phase 2
24 Tocopherols Phase 4,Phase 3
25 Tocotrienols Phase 4,Phase 3
26 Dermatologic Agents Phase 4,Phase 3
27 Trace Elements Phase 4,Phase 3,Phase 1,Phase 2
28 Vitamin B 12 Phase 4,Phase 3,Phase 2
29 Vitamin B 6 Phase 4,Phase 3,Phase 2
30 Vitamin B Complex Phase 4,Phase 3,Phase 1,Phase 2
31 Vitamins Phase 4,Phase 3,Phase 1,Phase 2
32 Photosensitizing Agents Phase 4,Phase 3
33 Retinol palmitate Phase 4,Phase 3,Phase 2
34 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2
35 cadexomer iodine Phase 4,Phase 3,Phase 2
36 Hematinics Phase 4,Phase 3,Phase 2
37 Vasodilator Agents Phase 4
38 Ergocalciferols Phase 4
39 Hypolipidemic Agents Phase 4
40 Ferrous fumarate Phase 4,Phase 2
41 Protective Agents Phase 4,Phase 3
42 Liver Extracts Phase 4
43 Lipid Regulating Agents Phase 4
44 Antimetabolites Phase 4
45 Bone Density Conservation Agents Phase 4,Phase 3
46 Antioxidants Phase 4,Phase 3
47 Folate Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
48 Vitamin B12 Nutraceutical Phase 4,Phase 3,Phase 2
49 Tocopherol Nutraceutical Phase 4,Phase 3
50 Tocotrienol Nutraceutical Phase 4,Phase 3

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4
2 Prevention of Renal Complications of Diabetes With Thiamine Unknown status NCT01725412 Phase 4
3 A Trial of Thiamin Supplementation in Patients With Heart Failure Completed NCT00959075 Phase 4
4 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
5 Effect of Prenatal Nutritional Supplementation on Birth Outcome in Hounde District, Burkina Faso Completed NCT00909974 Phase 4
6 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
7 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4
8 Thiamin Deficiency in Obese Thai Children Recruiting NCT02464865 Phase 4
9 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4
10 Trace Element Replenishment Study in Hemodialysis Patients Completed NCT01473914 Phase 3
11 Antenatal Micronutrient Supplementation and Infant Survival Completed NCT00860470 Phase 3
12 Trial of Vitamins Among Children of HIV-infected Women Completed NCT00197730 Phase 3
13 Trial of Vitamins in HIV Progression and Transmission Completed NCT00197743 Phase 3
14 A Trial of Vitamins and HAART in HIV Disease Progression Completed NCT00383669 Phase 3
15 Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes Active, not recruiting NCT01665378 Phase 3
16 Thiamine as a Metabolic Resuscitator in Septic Shock Completed NCT01070810 Phase 1, Phase 2
17 Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Not yet recruiting NCT02974257 Phase 2
18 NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes Not yet recruiting NCT02959125 Phase 2
19 Thiamin Fortified Fish Sauce as a Means of Combating Infantile Beriberi in Rural Cambodia Completed NCT02221063 Phase 1
20 Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants Completed NCT01864057 Phase 1
21 Thiamine Supplementation in Patients With Septic Shock Recruiting NCT03122678 Phase 1
22 Study of Dry Beriberi in Mayotte, Comoro Archipelago Unknown status NCT00934349
23 Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients Unknown status NCT02164487
24 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207
25 Multiple Nutritional Deficiencies Causing Dementia of the Alzheimer Type Unknown status NCT01479855
26 The Effectiveness of Micronutrient Supplements on Growth and Educational Achievement of Schoolchildren in Bangladesh Unknown status NCT00859911
27 Complications After Bariatric Surgery - a Clinical Trial Unknown status NCT01930838
28 Nutritional Status of Patients Victims of Haemorragic Accidents With Antivitamins K Unknown status NCT01742871
29 The Prevalence of Thiamin Deficiency in Ambulatory Patients With Heart Failure Completed NCT00953823
30 Thiamine Supplement in Patients With Severe Hyperthyroidism Completed NCT02767245
31 Iron Absorption From a Micronutrient Powder Containing Galacto-oligosaccharides (GOS) Completed NCT02666417
32 In Utero Capacity Formation and Socio-economic Outcomes Completed NCT01412580
33 Iron and Prebiotics Fortification in Kenyan Infants Completed NCT02118402
34 Evaluation of the Dietary Supplement Refill Bypass to Reduce Nutritional Deficiencies of Patients Who Underwent Bariatric Surgery Completed NCT02440087
35 Changes in Microbiota and Iron Status After Iron Fortification of Complementary Foods Completed NCT01111864
36 Assessing the Quality of Breast Milk Completed NCT02756026
37 Vitamin B Therapy for Hyperlactatemia Completed NCT00031057
38 Vitamin and Mineral Supplementation Improves Micronutrient Status in Older Adults Recruiting NCT03061409
39 Comparison of Two Nutrition Interventions in Young Children in El Salvador Recruiting NCT02567981
40 Effect of Timing of Micronutrient Powder Consumption on Iron Absorption in Infants Active, not recruiting NCT02989311
41 Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation Active, not recruiting NCT02428647
42 A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs Withdrawn NCT00037063

Search NIH Clinical Center for Beriberi

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: beriberi

Genetic Tests for Beriberi

Anatomical Context for Beriberi

MalaCards organs/tissues related to Beriberi:

39
Heart, Endothelial, Liver, Brain

Publications for Beriberi

Articles related to Beriberi:

(show top 50) (show all 266)
id Title Authors Year
1
Cranial Ultrasonography in Infantile Encephalitic Beriberi: A Useful First-Line Imaging Tool for Screening and Diagnosis in Suspected Cases. ( 27056426 )
2016
2
Case report: pericardial effusion with constrictive physiology in a patient with wet beriberi. ( 27059308 )
2016
3
Acute Abdominal Pain as a Presenting Symptom of Beriberi in a Pediatric Patient. ( 27329387 )
2016
4
An unusual case of cardiogenic shock in which thiamine administration led to reversal of lactic acidosis and heart function recovery: Shoshin beriberi in an adolescent. ( 27505323 )
2016
5
Beriberi Induced Cardiomyopathy Requiring Salvage Venoarterial Extracorporeal Membrane Oxygenation. ( 28050289 )
2016
6
Wernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar. ( 26697247 )
2015
7
Beriberi in Cambodia. ( 26744150 )
2015
8
Shoshin Beriberi in Critically-Ill patients: case series. ( 25982313 )
2015
9
Infantile encephalitic beriberi: magnetic resonance imaging findings. ( 26286085 )
2015
10
Elevated Lactate Secondary to Gastrointestinal Beriberi. ( 25876741 )
2015
11
Shoshin Beriberi With Low Cardiac Output and Hemodynamic Deterioration Treated Dramatically by Thiamine Administration. ( 26346515 )
2015
12
Beriberi (thiamine deficiency) and high infant mortality in northern laos. ( 25781926 )
2015
13
Beriberi in Cambodia. ( 25837026 )
2015
14
Dry beriberi preceded Wernicke's encephalopathy: Thiamine deficiency after laparoscopic sleeve gastrectomy. ( 26557183 )
2015
15
High-Output Heart Failure Caused by Thyrotoxicosis and Beriberi. ( 26567494 )
2015
16
Beriberi: an uncommon complication of Sleeve gastrectomy. ( 26499354 )
2015
17
A case of shoshin beriberi presenting as cardiogenic shock with diffuse ST-segment elevation, which dramatically improved after a single dose of thiamine. ( 25625639 )
2014
18
Acute dilated cardiomyopathy in a patient with beriberi and cryoglobulinaemic vasculitis: an unusual potential complication of two rare disorders. ( 24429381 )
2014
19
Christmas Island over 100 years: from beriberi to nutritional deficiencies of a different kind. ( 24890491 )
2014
20
Clinical history and colliquative myocytolysis are keys to the diagnosis of shoshin beriberi. ( 24891966 )
2014
21
Beriberi, a severe complication after metabolic surgery - review of the literature. ( 25095897 )
2014
22
Shoshin beriberi induced by long-term administration of diuretics: a case report. ( 25105030 )
2014
23
Total parenteral nutrition caused Wernicke's encephalopathy accompanied by wet beriberi. ( 24516692 )
2014
24
Analysis of thiamine transporter genes in sporadic beriberi. ( 24607307 )
2014
25
A case of cardiac beriberi: a forgotten but memorable disease. ( 24044018 )
2013
26
Inducible intrapulmonary arteriovenous shunt in a patient with beriberi heart. ( 23378443 )
2013
27
A case of Shoshin Beriberi: lessons old and new for the psychiatrist. ( 22658327 )
2013
28
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
29
Use of central venous saturation monitoring in a patient with pediatric cardiac beriberi. ( 24303502 )
2013
30
Adolphe Vorderman's 1897 study on beriberi: an example of scrupulous efforts to avoid bias. ( 23481433 )
2013
31
An eating disorder leading to wet beriberi heart failure in a 30-year-old woman. ( 23158607 )
2013
32
Beriberi in a dialysis patient: do we need more thiamine? ( 23399344 )
2013
33
Altered and unstable: wet beriberi, a clinical review. ( 23849362 )
2013
34
Kanehiro Takaki and the control of beriberi in the Japanese Navy. ( 23897451 )
2013
35
Thiamine deficiency, beriberi, and maternal and child health: why pharmacokinetics matter. ( 23902781 )
2013
36
Thiamine deficiency in Cambodian infants with and without beriberi. ( 22703952 )
2012
37
Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery. ( 22525460 )
2012
38
Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency. ( 22136604 )
2012
39
Case of beriberi showing improved cerebral blood flow after thiamine treatment. ( 22998382 )
2012
40
Beriberi disease: is it still present in the United States? ( 22800868 )
2012
41
Subacute myeloa89optic neuropathy, beriberi, and HTLVa89Ia89associated myelopathy: elucidation of some neurological diseases in Japan. ( 23222550 )
2012
42
Increase of serum vascular endothelial growth factors in wet beriberi: two case reports. ( 22504253 )
2012
43
Clinical correlates and outcome of shoshin beriberi. ( 23112976 )
2012
44
Shoshin beriberi mimicking a high-risk non-ST-segment elevation acute coronary syndrome with cardiogenic shock: when the arteries are not guilty. ( 18930369 )
2011
45
A retrospective investigation of thiamin and energy intakes following an outbreak of beriberi in The Gambia. ( 22254079 )
2011
46
Cardiac beriberi: morphological findings in two fatal cases. ( 21244717 )
2011
47
Cardiovascular magnetic resonance in wet beriberi. ( 21838901 )
2011
48
Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi? ( 21941485 )
2011
49
Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberi. ( 21364976 )
2011
50
Outbreak of beriberi among African Union troops in Mogadishu, Somalia. ( 22205947 )
2011

Variations for Beriberi

Expression for Beriberi

Search GEO for disease gene expression data for Beriberi.

Pathways for Beriberi

GO Terms for Beriberi

Biological processes related to Beriberi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.5 EPHA3 KALRN TPK1
2 ephrin receptor signaling pathway GO:0048013 9.26 EPHA3 KALRN
3 thiamine transmembrane transport GO:0071934 9.16 SLC19A2 SLC19A3
4 thiamine transport GO:0015888 8.96 SLC19A2 SLC19A3
5 thiamine-containing compound metabolic process GO:0042723 8.8 SLC19A2 SLC19A3 TPK1

Molecular functions related to Beriberi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.46 EPHA3 KALRN TKT TPK1
2 kinase activity GO:0016301 9.43 EPHA3 KALRN TPK1
3 thiamine transmembrane transporter activity GO:0015234 8.96 SLC19A2 SLC19A3
4 thiamine uptake transmembrane transporter activity GO:0015403 8.62 SLC19A2 SLC19A3

Sources for Beriberi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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