MCID: BRY001
MIFTS: 43

Berylliosis malady

Rare diseases, Respiratory diseases categories

Aliases & Classifications for Berylliosis

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Aliases & Descriptions for Berylliosis:

Name: Berylliosis 8 42
Subacute Berylliosis 42 61
Acute Berylliosis 42 61
 
Chronic Pulmonary Berylliosis 42
Reversible Berylliosis 42
Beryllium Poisoning 8


Classifications:



External Ids:

Disease Ontology8 DOID:10322
MeSH33 D001607
SNOMED-CT56 8247009
ICD1025 J63.2

Summaries for Berylliosis

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Disease Ontology:8 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and capillary leak syndrome. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are IL2 signaling events mediated by PI3K and Immune response IL 2 activation and signaling pathway. The compounds r-il-2 and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and testes, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:64 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

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Diseases in the Berylliosis family:

Chronic Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1chronic berylliosis10.7
2capillary leak syndrome10.5IL2
3ulcerative colitis10.4ALB
4thyroiditis10.4HLA-DRB1
5silicosis10.3
6complete atrioventricular canal10.3
7t-cell large granular lymphocyte leukemia10.2IL2, IL2RB
8severe combined immunodeficiency, x-linked10.2IL2, IL2RB
9common variable immunodeficiency10.2IL2, IL2RB
10hcl-v10.2IL2, IL2RB
11leprosy10.2IL2, HLA-DRB1
12uveitis10.2IFNG
13mycosis fungoides10.2IL2RB, IL2
14acquired immunodeficiency syndrome10.2IL2, ALB
15asbestosis10.2
16lipoid nephrosis10.2IL2RB, ALB
17leukopenia10.2IL2, ALB
18kidney cancer10.2IL2, IL2RB
19cork-handlers' disease10.2ALB, IL2
20diphtheria10.1IL2RB, IL2
21polymyalgia rheumatica10.1HLA-DRB1, IL2RB
22diarrhea10.1ALB, IL2
23juvenile rheumatoid arthritis10.1HLA-DRB1, IL2RB
24lepromatous leprosy10.1IL2, IFNG
25nutritional deficiency disease10.1IL2RB, ALB
26chronic lymphocytic leukemia10.1IL2RB, IL2
27toxic shock syndrome10.1IL2, IFNG
28factor vii deficiency10.1IL2, IFNG
29myasthenia gravis10.1IFNG, IL2
30pulmonary hypertension10.0
31rheumatic fever10.0
32pneumoconiosis10.0
33precursor t-cell acute lymphoblastic leukemia10.0IL2, IL2RB
34diabetes mellitus, insulin-dependent10.0IFNG, HLA-DRB1
35plasmodium falciparum malaria10.0HLA-DRB1, IFNG
36skin disease10.0IL2, HLA-DRB1, ALB
37connective tissue disease10.0HLA-DRB1, IL2, ALB
38hypersensitivity reaction type ii disease10.0ALB, IL2, HLA-DRB1
39lymphoma, non-hodgkin10.0IL2RB, IL2, HLA-DRB1
40systemic scleroderma10.0IL2RB, HLA-DRB1
41pulmonary fibrosis, idiopathic10.0IL2RB, IFNG
42hepatitis9.9HLA-DRB1, IL2RB, ALB
43primary biliary cirrhosis9.9HLA-DRB1, IL2RB, ALB
44thrombocytopenia9.9ALB, IL2
45tropical spastic paraparesis9.9IFNG, IL2, IL2RB
46acute graft versus host disease9.9IFNG, IL2RB, IL2
47sezary's disease9.9IL2RB, IL2, IFNG
48pulmonary sarcoidosis9.9IFNG, IL2, IL2RB
49lymphopenia9.9IFNG, IL2RB, IL2
50cutaneous t cell lymphoma9.9IFNG, IL2RB, IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Drug clinical trials:

Search ClinicalTrials for Berylliosis

Search NIH Clinical Center for Berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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MalaCards organs/tissues related to Berylliosis:

31
Lung, Testes, T cells, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

14
Lungs

Animal Models for Berylliosis or affiliated genes

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MGI Mouse Phenotypes related to Berylliosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ALB, IL2RB, IL2, IFNG
2MP:00053707.9ALB, IL2RB, IL2, IFNG

Publications for Berylliosis

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Articles related to Berylliosis:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. (10954202)
2000
7
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
8
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
9
Chronic berylliosis of the lung: report of a case. (16892748)
1996
10
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
11
Berylliosis. (2138073)
1990
12
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
13
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
14
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
15
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
16
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
17
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
18
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
19
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
20
Research into what happens in berylliosis. (1048889)
1976
21
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
22
Immunologic aspects of chronic berylliosis. (4540228)
1973
23
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
24
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
25
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
26
Immunoglobulin levels in berylliosis. (4129664)
1970
27
Pulmonary berylliosis: a case report. (6083249)
1967
28
Chronic berylliosis and calcospherite deposition. (5901642)
1966
29
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
30
Chronic berylliosis. (14498247)
1962
31
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
32
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
33
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
34
Beryllium and berylliosis. (13580272)
1958
35
Berylliosis. (14371570)
1955
36
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
37
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
38
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
39
Berylliosis; a new disease. (14933466)
1952
40
Chronic berylliosis in the neon sign industry. (14837525)
1951
41
Berylliosis and silicosis. (14841360)
1951
42
Some aspects of berylliosis. (14819024)
1951
43
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Berylliosis. (14771889)
1950
46
Non-occupational berylliosis. (18141686)
1949
47
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
48
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
49
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948
50
Berylliosis. (18102274)
1948

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL2 signaling events mediated by STAT536
9.6IL2, IL2RB
2
Show member pathways
Immune response IL 3 activation and signaling pathway59
9.6IL2, IL2RB
3
Show member pathways
9.6IL2, IL2RB
4
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4IL2, IFNG
59.4IFNG, IL2
6
Show member pathways
IL27-mediated signaling events36
9.4IFNG, IL2
79.4IFNG, IL2
89.4IFNG, IL2
99.4IFNG, IL2
109.4IFNG, IL2
119.4IFNG, IL2
129.4HLA-DRB1, HLA-DPA1
139.4HLA-DRB1, HLA-DPA1
14
Show member pathways
9.4HLA-DRB1, HLA-DPA1
15
Show member pathways
9.4HLA-DPA1, HLA-DRB1
16
Show member pathways
9.4HLA-DRB1, HLA-DPA1
17
Show member pathways
thioredoxin pathway36
9.0ALB, IFNG
18
Show member pathways
9.0HLA-DPA1, HLA-DRB1, IL2
19
Show member pathways
Type III interferon signaling36
9.0IFNG, IL2, IL2RB
20
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0IFNG, IL2, IL2RB
21
Show member pathways
9.0IFNG, IL2, IL2RB
22
Show member pathways
9.0IFNG, IL2, IL2RB
23
Show member pathways
IL-2 Signaling pathway36
9.0IFNG, IL2, IL2RB
24
Show member pathways
9.0IFNG, IL2RB, IL2
259.0IL2RB, IL2, IFNG
268.9IL2, HLA-DRB1, IFNG
278.9IFNG, HLA-DRB1, IL2
288.8HLA-DPA1, IFNG, HLA-DRB1
298.8IFNG, HLA-DRB1, HLA-DPA1
30
Show member pathways
8.8HLA-DRB1, IFNG, HLA-DPA1
318.8IFNG, HLA-DRB1, HLA-DPA1
328.6HLA-DRB1, IL2, HLA-DPA1, IL2RB
33
Show member pathways
8.6HLA-DPA1, HLA-DRB1, IL2RB, IL2
34
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
8.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
35
Show member pathways
Immune response IL 12 induced IFN gamma production59
8.5IL2, IL2RB, HLA-DRB1, IFNG
36
Show member pathways
8.4IFNG, HLA-DRB1, HLA-DPA1, IL2
37
Show member pathways
8.4HLA-DPA1, IL2, IFNG, HLA-DRB1
38
Show member pathways
7.9HLA-DPA1, IL2RB, IL2, IFNG, HLA-DRB1
39
Show member pathways
7.9HLA-DRB1, IFNG, IL2, IL2RB, HLA-DPA1
40
Show member pathways
7.9IL2RB, IFNG, HLA-DPA1, HLA-DRB1, IL2

Compounds for genes affiliated with Berylliosis

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Compounds related to Berylliosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1r-il-24410.0IL2, IL2RB
2denileukin diftitox44 50 1112.0IL2, IL2RB
3ctla4-ig4410.0IL2RB, IL2
4daclizumab44 1111.0IL2, IL2RB
5basiliximab44 1110.9IL2, IL2RB
6alemtuzumab44 1110.9IL2RB, IL2
7levamisole44 1110.9IL2RB, IL2
8chromium449.9IL2RB, IL2
9interferon gamma449.8IFNG, IL2
10dpa 1449.8HLA-DRB1, HLA-DPA1
11bucillamine449.8IL2, IFNG
12alpha-galactosylceramide449.8IL2, IFNG
13taurine chloramine449.8IFNG, IL2
14pirfenidone44 6010.8IFNG, IL2
15fumarate44 1110.7IFNG, IL2
16il-12449.7IL2, IFNG
17piroxicam44 1110.5IL2, ALB
18zoledronic acid449.5IL2, IFNG
19gm-csf44 2810.4IFNG, IL2
20sulfamethoxazole50 44 1111.4IL2, ALB
21polyinosinic-polycytidylic acid449.4IL2, IFNG
22okt3449.4IFNG, IL2, IL2RB
23con a449.4IL2, IL2RB, IFNG
242,5-oligoadenylate449.4IL2, IFNG, IL2RB
25il 10449.4IFNG, IL2RB, IL2
26gamma globulin449.4IFNG, ALB
27pentoxifylline44 1110.4IFNG, IL2, IL2RB
28ifn-alpha449.4IL2RB, IL2, IFNG
29neopterin449.4IL2RB, IL2, IFNG
30glatiramer acetate44 1110.4IL2, IFNG, HLA-DRB1
31gold sodium thiomalate449.4IL2, IFNG, HLA-DRB1
32ionomycin449.4IL2RB, IL2, IFNG
33polysulfone449.3IL2RB, ALB
34triptolide449.3IL2, IFNG
35rantes449.3IL2, IL2RB, IFNG
36aminoguanidine44 28 1111.3IFNG, ALB
37mycophenolic acid44 50 1111.2ALB, IL2, IL2RB
38naloxone44 28 50 1112.2IL2, ALB, IL2RB
39l-tryptophan50 28 44 24 1113.2IFNG, ALB
40rapamycin449.1IL2RB, IFNG, IL2
41methotrexate50 44 1111.0IL2RB, HLA-DRB1, ALB
42ivig449.0IFNG, ALB, IL2RB
43calcitriol44 60 24 1112.0IL2, IFNG, ALB
44indomethacin44 28 60 1111.9IL2, IFNG, ALB
45genistein44 28 60 1 24 1113.7IL2RB, IFNG, IL2
46auranofin28 44 60 1111.6IL2, IL2RB, IFNG, ALB
47mycophenolate mofetil44 50 1110.6IL2, IFNG, ALB, IL2RB
48prednisolone44 28 1110.6IL2, ALB, IL2RB, IFNG
49tacrolimus44 50 1110.6IFNG, IL2, IL2RB, ALB
50histamine44 28 2410.6ALB, IL2RB, IL2, IFNG

GO Terms for genes affiliated with Berylliosis

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Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.6HLA-DRB1, HLA-DPA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.5HLA-DRB1, HLA-DPA1
3clathrin-coated endocytic vesicle membraneGO:00306699.5HLA-DPA1, HLA-DRB1
4transport vesicle membraneGO:00306589.4HLA-DRB1, HLA-DPA1
5endocytic vesicle membraneGO:00306669.4HLA-DRB1, HLA-DPA1
6ER to Golgi transport vesicle membraneGO:00125079.3HLA-DRB1, HLA-DPA1
7trans-Golgi network membraneGO:00325889.1HLA-DRB1, HLA-DPA1
8external side of plasma membraneGO:00098979.1IL2RB, IFNG, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:00483049.6IL2, IFNG
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.4HLA-DRB1, HLA-DPA1
3T cell costimulationGO:00312959.3HLA-DPA1, HLA-DRB1
4T cell receptor signaling pathwayGO:00508529.1HLA-DRB1, HLA-DPA1
5immune responseGO:00069559.1HLA-DPA1, HLA-DRB1, IL2
6interferon-gamma-mediated signaling pathwayGO:00603339.0HLA-DPA1, HLA-DRB1, IFNG
7negative regulation of apoptotic processGO:00430668.8ALB, IL2RB, IL2
8cytokine-mediated signaling pathwayGO:00192218.5IL2RB, IFNG, HLA-DRB1, HLA-DPA1

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.4HLA-DRB1, HLA-DPA1

Sources for Berylliosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet