MCID: BRY001
MIFTS: 51

Berylliosis malady

Rare diseases, Respiratory diseases categories
Download this MalaCard

Summaries for Berylliosis

About this section


Fully expand this MalaCard
Disease Ontology:8 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and capillary leak syndrome. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are Immune response IL 2 activation and signaling pathway and IL2 signaling events mediated by PI3K. The compounds r-il-2 and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and testes, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:65 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Aliases & Classifications for Berylliosis

About this section

Berylliosis, Aliases & Descriptions:

Name: Berylliosis 8 42
Subacute Berylliosis 42 62
Acute Berylliosis 42 62
 
Chronic Pulmonary Berylliosis 42
Reversible Berylliosis 42
Beryllium Poisoning 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:10322
MeSH34 D001607
SNOMED-CT57 8247009
ICD1025 J63.2

Related Diseases for Berylliosis

About this section

Diseases in the Berylliosis family:

Chronic Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1chronic berylliosis10.7
2capillary leak syndrome10.5IL2
3ulcerative colitis10.4ALB
4thyroiditis10.4HLA-DRB1
5silicosis10.3
6t-cell large granular lymphocyte leukemia10.2IL2, IL2RB
7gamma chain deficiency10.2IL2, IL2RB
8common variable immunodeficiency10.2IL2, IL2RB
9leprosy10.2IL2, HLA-DRB1
10hairy cell leukemia10.2IL2, IL2RB
11uveitis10.2IFNG
12mycosis fungoides10.2IL2RB, IL2
13acquired immunodeficiency syndrome10.2IL2, ALB
14lipoid nephrosis10.2IL2RB, ALB
15leukopenia10.2IL2, ALB
16asbestosis10.2
17kidney rhabdoid cancer10.2IL2, IL2RB
18cork-handlers' disease10.2ALB, IL2
19diphtheria10.2IL2RB, IL2
20polymyalgia rheumatica10.2HLA-DRB1, IL2RB
21diarrhea10.1ALB, IL2
22juvenile rheumatoid arthritis10.1HLA-DRB1, IL2RB
23lepromatous leprosy10.1IL2, IFNG
24chronic lymphocytic leukemia10.1IL2RB, IL2
25toxic shock syndrome10.1IL2, IFNG
26factor vii deficiency10.1IL2, IFNG
27myasthenia gravis10.1IFNG, IL2
28hypertension10.0
29pulmonary hypertension10.0
30rheumatic fever10.0
31pneumoconiosis10.0
32klebsiella10.0
33precursor t-cell acute lymphoblastic leukemia10.0IL2, IL2RB
34type 1 diabetes mellitus10.0IFNG, HLA-DRB1
35plasmodium falciparum malaria10.0HLA-DRB1, IFNG
36skin disease10.0IL2, HLA-DRB1, ALB
37connective tissue disease10.0HLA-DRB1, IL2, ALB
38hypersensitivity reaction type ii disease10.0ALB, IL2, HLA-DRB1
39systemic scleroderma10.0IL2RB, HLA-DRB1
40non-hodgkin lymphoma10.0IL2RB, IL2, HLA-DRB1
41idiopathic pulmonary fibrosis10.0IL2RB, IFNG
42hepatitis9.9HLA-DRB1, IL2RB, ALB
43primary biliary cirrhosis9.9HLA-DRB1, IL2RB, ALB
44thrombocytopenia9.9ALB, IL2
45tropical spastic paraparesis9.9IFNG, IL2, IL2RB
46acute graft versus host disease9.9IFNG, IL2RB, IL2
47sezary's disease9.9IL2RB, IL2, IFNG
48pulmonary sarcoidosis9.9IFNG, IL2, IL2RB
49lymphopenia9.9IFNG, IL2RB, IL2
50cutaneous t cell lymphoma9.9IFNG, IL2RB, IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

About this section

Drugs & Therapeutics for Berylliosis

About this section

Drug clinical trials:

Search ClinicalTrials for Berylliosis

Search NIH Clinical Center for Berylliosis

Genetic Tests for Berylliosis

About this section

Anatomical Context for Berylliosis

About this section

MalaCards organs/tissues related to Berylliosis:

32
Lung, Testes, T cells, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

14
Lungs

Animal Models for Berylliosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Berylliosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ALB, IL2RB, IL2, IFNG
2MP:00053707.9ALB, IL2RB, IL2, IFNG

Publications for Berylliosis

About this section

Articles related to Berylliosis:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
7
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
8
Chronic berylliosis of the lung: report of a case. (16892748)
1996
9
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
10
Berylliosis. (2138073)
1990
11
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
12
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
13
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
14
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
15
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
16
Berylliosis. (7381961)
1980
17
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
18
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
19
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
20
Research into what happens in berylliosis. (1048889)
1976
21
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
22
Chronic berylliosis. (4274186)
1973
23
Immunologic aspects of chronic berylliosis. (4540228)
1973
24
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
25
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
26
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
27
Immunoglobulin levels in berylliosis. (4129664)
1970
28
Pulmonary berylliosis: a case report. (6083249)
1967
29
Chronic berylliosis and calcospherite deposition. (5901642)
1966
30
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
31
Chronic berylliosis. (14498247)
1962
32
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
33
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
34
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
35
Beryllium and berylliosis. (13580272)
1958
36
Berylliosis. (14371570)
1955
37
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
38
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
39
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
40
Berylliosis; a new disease. (14933466)
1952
41
Berylliosis and silicosis. (14841360)
1951
42
Some aspects of berylliosis. (14819024)
1951
43
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Berylliosis. (14771889)
1950
46
Non-occupational berylliosis. (18141686)
1949
47
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
48
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
49
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948
50
Berylliosis. (18102274)
1948

Variations for Berylliosis

About this section

Expression for genes affiliated with Berylliosis

About this section
Expression patterns in normal tissues for genes affiliated with Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

About this section

Pathways related to Berylliosis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.6IL2RB, IL2
2
Show member pathways
IL2 signaling events mediated by STAT537
9.6IL2RB, IL2
3
Show member pathways
9.6IL2RB, IL2
49.4IL2, IFNG
59.4IL2, IFNG
69.4IL2, IFNG
79.4IL2, IFNG
89.4IFNG, IL2
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4IFNG, IL2
109.4IFNG, IL2
11
Show member pathways
IL27-mediated signaling events37
9.4IFNG, IL2
12
Show member pathways
9.4HLA-DRB1, HLA-DPA1
139.4HLA-DRB1, HLA-DPA1
14
Show member pathways
9.4HLA-DRB1, HLA-DPA1
159.4HLA-DRB1, HLA-DPA1
16
Show member pathways
9.4HLA-DRB1, HLA-DPA1
17
Show member pathways
thioredoxin pathway37
9.0ALB, IFNG
18
Show member pathways
9.0HLA-DPA1, HLA-DRB1, IL2
19
Show member pathways
9.0IL2RB, IL2, IFNG
20
Show member pathways
Type III interferon signaling37
9.0IL2RB, IL2, IFNG
219.0IL2RB, IL2, IFNG
22
Show member pathways
9.0IFNG, IL2, IL2RB
23
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.0IFNG, IL2, IL2RB
24
Show member pathways
IL-2 Signaling pathway37
9.0IL2RB, IL2, IFNG
25
Show member pathways
9.0IL2RB, IL2, IFNG
268.9IL2, IFNG, HLA-DRB1
278.9HLA-DRB1, IFNG, IL2
288.8IFNG, HLA-DRB1, HLA-DPA1
298.8HLA-DPA1, HLA-DRB1, IFNG
308.8HLA-DPA1, HLA-DRB1, IFNG
31
Show member pathways
8.8HLA-DPA1, HLA-DRB1, IFNG
32
Show member pathways
8.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
338.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
34
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.6HLA-DPA1, HLA-DRB1, IL2, IL2RB
35
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.5IL2RB, IL2, IFNG, HLA-DRB1
36
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
37
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
38
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
39
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
40
Show member pathways
7.9IL2RB, IL2, IFNG, HLA-DRB1, HLA-DPA1

Compounds for genes affiliated with Berylliosis

About this section

Compounds related to Berylliosis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1r-il-24410.0IL2RB, IL2
2denileukin diftitox44 50 1112.0IL2RB, IL2
3ctla4-ig4410.0IL2, IL2RB
4daclizumab44 1111.0IL2RB, IL2
5basiliximab44 1110.9IL2RB, IL2
6alemtuzumab44 1110.9IL2RB, IL2
7levamisole44 1110.9IL2, IL2RB
8chromium449.9IL2RB, IL2
9interferon gamma449.8IL2, IFNG
10dpa 1449.8HLA-DPA1, HLA-DRB1
11bucillamine449.8IFNG, IL2
12alpha-galactosylceramide449.8IL2, IFNG
13taurine chloramine449.8IL2, IFNG
14pirfenidone44 6110.7IL2, IFNG
15fumarate44 1110.7IFNG, IL2
16il-12449.7IL2, IFNG
17piroxicam44 1110.6ALB, IL2
18zoledronic acid449.5IL2, IFNG
19sulfamethoxazole50 44 1111.4ALB, IL2
20gm-csf44 2810.4IFNG, IL2
21polyinosinic-polycytidylic acid449.4IL2, IFNG
22okt3449.4IL2RB, IL2, IFNG
23con a449.4IL2RB, IL2, IFNG
242,5-oligoadenylate449.4IFNG, IL2, IL2RB
25gamma globulin449.4ALB, IFNG
26il 10449.4IFNG, IL2, IL2RB
27pentoxifylline44 1110.4IFNG, IL2, IL2RB
28ifn-alpha449.4IL2RB, IL2, IFNG
29neopterin449.4IL2RB, IL2, IFNG
30gold sodium thiomalate449.4HLA-DRB1, IFNG, IL2
31glatiramer acetate44 1110.4HLA-DRB1, IFNG, IL2
32ionomycin449.4IFNG, IL2, IL2RB
33polysulfone449.3IL2RB, ALB
34triptolide449.3IFNG, IL2
35rantes449.3IFNG, IL2, IL2RB
36aminoguanidine44 28 1111.3ALB, IFNG
37mycophenolic acid44 50 1111.2IL2, IL2RB, ALB
38naloxone44 28 50 1112.2ALB, IL2RB, IL2
39l-tryptophan50 28 44 24 1113.2ALB, IFNG
40rapamycin449.1IL2RB, IL2, IFNG
41methotrexate50 44 1111.0HLA-DRB1, IL2RB, ALB
42ivig449.0ALB, IL2RB, IFNG
43calcitriol44 61 24 1112.0ALB, IL2, IFNG
44indomethacin44 28 61 1111.9IFNG, IL2, ALB
45genistein44 28 61 2 24 1113.7IL2RB, IL2, IFNG
46auranofin28 44 61 1111.6ALB, IL2RB, IL2, IFNG
47mycophenolate mofetil44 50 1110.6IFNG, IL2, IL2RB, ALB
48prednisolone44 28 1110.6ALB, IL2RB, IL2, IFNG
49tacrolimus44 50 1110.6ALB, IL2RB, IL2, IFNG
50histamine44 28 2410.6ALB, IL2RB, IL2, IFNG

GO Terms for genes affiliated with Berylliosis

About this section

Cellular components related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.6HLA-DRB1, HLA-DPA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DRB1, HLA-DPA1
3clathrin-coated endocytic vesicle membraneGO:0306699.5HLA-DPA1, HLA-DRB1
4transport vesicle membraneGO:0306589.4HLA-DRB1, HLA-DPA1
5endocytic vesicle membraneGO:0306669.4HLA-DRB1, HLA-DPA1
6ER to Golgi transport vesicle membraneGO:0125079.3HLA-DRB1, HLA-DPA1
7trans-Golgi network membraneGO:0325889.1HLA-DRB1, HLA-DPA1
8external side of plasma membraneGO:0098979.1IL2RB, IFNG, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IFNG
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.4HLA-DRB1, HLA-DPA1
3T cell costimulationGO:0312959.3HLA-DPA1, HLA-DRB1
4T cell receptor signaling pathwayGO:0508529.1HLA-DRB1, HLA-DPA1
5immune responseGO:0069559.1HLA-DPA1, HLA-DRB1, IL2
6interferon-gamma-mediated signaling pathwayGO:0603339.0HLA-DPA1, HLA-DRB1, IFNG
7negative regulation of apoptotic processGO:0430668.8ALB, IL2RB, IL2
8cytokine-mediated signaling pathwayGO:0192218.5IL2RB, IFNG, HLA-DRB1, HLA-DPA1

Molecular functions related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.4HLA-DRB1, HLA-DPA1

Products for genes affiliated with Berylliosis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Berylliosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet