Aliases & Classifications for Berylliosis

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Aliases & Descriptions for Berylliosis:

Name: Berylliosis 11 13 37
 
Beryllium Poisoning 11

Classifications:



External Ids:

Disease Ontology11 DOID:10322
ICD1028 J63.2
SNOMED-CT60 8247009
MeSH37 D001607

Summaries for Berylliosis

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Disease Ontology:11 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as beryllium poisoning, is related to chronic beryllium disease and beryllium disease. An important gene associated with Berylliosis is IFNG (Interferon Gamma), and among its related pathways are Downstream signaling in naive CD8+ T cells and Th2 Differentiation Pathway. Affiliated tissues include lungs, lung and t cells.

Wikipedia:69 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

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Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1chronic beryllium disease11.7
2beryllium disease11.7
3lymphocytic colitis10.5HLA-DRB1, IFNG
4chronic polyneuropathy10.5HLA-DRB1, IFNG
5hernia of ovary and fallopian tube10.5HLA-DRB1, IFNG
6orbit alveolar rhabdomyosarcoma10.5HLA-DRB1, IFNG
7aseptic osteitis10.5HLA-DRB1, IFNG
8duodenal benign neoplasm10.5HLA-DRB1, IFNG
9sensorineural hearing loss10.4HLA-DRB1, IFNG
10mastocytosis cutaneous with short stature conductive hearing loss and microtia10.4HLA-DRB1, IFNG
11hemophagocytic lymphohistiocytosis10.4HLA-DRB1, IFNG
12fibrous histiocytoma10.4HLA-DRB1, IFNG
13smooth muscle tumor10.4HLA-DRB1, IFNG
14bile duct signet ring cell carcinoma10.4HLA-DRB1, IFNG
15vitreoretinochoroidopathy dominant10.4HLA-DRB1, IL2
16reproductive system disease10.4HLA-DRB1, IFNG
17skin sarcoidosis10.4HLA-DRB1, IL2
18respiratory system disease10.4HLA-DRB1, IL2
19dermatitis herpetiformis, familial10.4HLA-DRB1, IFNG
20bulbospinal polio10.4IFNG, IL2
21dentinogenesis imperfecta10.4HLA-DRB1, IFNG
22graft-versus-host disease, protection against10.4IFNG, IL2
23thomsen and becker disease10.4IFNG, IL2
24addison's disease10.4IFNG, IL2
25amyotrophic lateral sclerosis type 410.4IFNG, IL2
26renovascular hypertension10.4HLA-DRB1, IL2
27iridocyclitis10.3HLA-DRB1, IL2
28calcifying epithelial odontogenic tumor10.3IFNG, IL2
29potter's syndrome10.3IFNG, IL2
30pneumonic tularemia10.3IFNG, IL2
31bolivian hemorrhagic fever10.3IFNG, IL2
32collagen disease10.3IFNG, IL2
33bartter disease10.3HLA-DRB1, IFNG
34hypospadias10.3IFNG, IL2
35lacrimal system cancer10.3IFNG, IL2
36parsonage turner syndrome10.3HLA-DPB1, HLA-DRB1
37myopathy-growth delay-intellectual disability-hypospadias syndrome10.3HLA-DPB1, HLA-DRB1
38pulmonary systemic sclerosis10.3HLA-DRB1, IFNG
39cd3zeta deficiency10.3IFNG, IL2
40louping ill10.3IFNG, IL2
41x-linked intellectual disability, siderius type10.3IFNG, IL2
42subendocardial infarction acute myocardial infarction10.3IFNG, IL2
43common cold10.3IFNG, IL2
44esophagus melanoma10.3IFNG, IL2
45bacteriuria10.3IFNG, IL2
46jejunal somatostatinoma10.3IFNG, IL2
47heart leiomyosarcoma10.3IFNG, IL2
48dengue disease10.3IFNG, IL2
49gastric ulcer10.3IFNG, IL2
50toxic maculopathy10.3IFNG, IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1MesalaminePhase 1, Phase 215689-57-6
2
infliximabPhase 1, Phase 2364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
3
Heparin7799005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
4calcium heparin779

Interventional clinical trials:

idNameStatusNCT IDPhase
1Targeting Oxidative Stress in Chronic Beryllium DiseaseCompletedNCT01088243Phase 1, Phase 2
2Beryllium Infliximab Study: Clinical Interventional TrialTerminatedNCT00111917Phase 1, Phase 2
3Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and SarcoidosisCompletedNCT00560989
4The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)RecruitingNCT02596347
5Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)RecruitingNCT02604693

Search NIH Clinical Center for Berylliosis


Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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MalaCards organs/tissues related to Berylliosis:

34
Lung, T cells, Testes, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

17
Lungs

Animal Models for Berylliosis or affiliated genes

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Publications for Berylliosis

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Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (11405518)
2001
6
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
7
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
8
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
9
Chronic berylliosis of the lung: report of a case. (16892748)
1996
10
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
11
Berylliosis. (2138073)
1990
12
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
13
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
14
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
15
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
16
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
17
Berylliosis. (7381961)
1980
18
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
19
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
20
Experimental aerogenic pulmonary berylliosis in rabbits. (147415)
1978
21
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
22
Chronic berylliosis. (4526035)
1974
23
Immunologic aspects of chronic berylliosis. (4540228)
1973
24
Chronic berylliosis. (4274186)
1973
25
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
26
Immunoglobulin levels in berylliosis. (4129664)
1970
27
The role of immunologic reactions in pulmonary berylliosis. (5527729)
1970
28
Pulmonary berylliosis: a case report. (6083249)
1967
29
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
30
Chronic berylliosis. (14498247)
1962
31
The mineral content of the lung in chronic berylliosis. (13991590)
1962
32
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. (13761591)
1961
33
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
34
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
35
BERYLLIOSIS. (13316118)
1956
36
Berylliosis. (14371570)
1955
37
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
38
Berylliosis; a real but preventable industrial disease. (13196701)
1954
39
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
40
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
41
Chronic berylliosis in the neon sign industry. (14837525)
1951
42
Berylliosis and silicosis. (14841360)
1951
43
Some aspects of berylliosis. (14819024)
1951
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
46
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
47
Non-occupational berylliosis. (18141686)
1949
48
Berylliosis. (18102274)
1948
49
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
50
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IFNG, IL2
29.6IFNG, IL2
3
Show member pathways
9.6IFNG, IL2
49.6IFNG, IL2
59.6IFNG, IL2
69.6IFNG, IL2
79.6IFNG, IL2
89.6IFNG, IL2
9
Show member pathways
9.6IFNG, IL2
109.6IFNG, IL2
119.6IFNG, IL2
129.3HLA-DPB1, HLA-DRB1
13
Show member pathways
9.1HLA-DRB1, IFNG, IL2
149.1HLA-DRB1, IFNG, IL2
159.1HLA-DRB1, IFNG, IL2
16
Show member pathways
8.9HLA-DPB1, HLA-DRB1, IFNG
17
Show member pathways
8.9HLA-DPB1, HLA-DRB1, IFNG
188.9HLA-DPB1, HLA-DRB1, IFNG
198.9HLA-DPB1, HLA-DRB1, IFNG
208.9HLA-DPB1, HLA-DRB1, IFNG
21
Show member pathways
8.9HLA-DPB1, HLA-DRB1, IL2
228.9HLA-DPB1, HLA-DRB1, IL2
238.8IFNG, IL2, POMC
24
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2
25
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2
26
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2

GO Terms for genes affiliated with Berylliosis

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Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.7HLA-DPB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.7HLA-DPB1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:00306699.6HLA-DPB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125079.6HLA-DPB1, HLA-DRB1
5trans-Golgi network membraneGO:00325889.4HLA-DPB1, HLA-DRB1
6endocytic vesicle membraneGO:00306669.3HLA-DPB1, HLA-DRB1
7transport vesicle membraneGO:00306589.2HLA-DPB1, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:00483049.9IFNG, IL2
2positive regulation of interferon-gamma productionGO:00327299.8HLA-DPB1, IL2
3T cell costimulationGO:00312959.3HLA-DPB1, HLA-DRB1
4interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DPB1, HLA-DRB1, IFNG
5T cell receptor signaling pathwayGO:00508528.9HLA-DPB1, HLA-DRB1, IFNG
6positive regulation of T cell proliferationGO:00421028.7HLA-DPB1, IFNG, IL2

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.3HLA-DPB1, HLA-DRB1

Sources for Berylliosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet