MCID: BRY001
MIFTS: 38

Berylliosis malady

Categories: Respiratory diseases

Aliases & Classifications for Berylliosis

Aliases & Descriptions for Berylliosis:

Name: Berylliosis 12 42 14
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
ICD10 33 J63.2
MeSH 42 D001607
SNOMED-CT 64 8247009
UMLS 69 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to chronic beryllium disease and beryllium disease. An important gene associated with Berylliosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes.

Wikipedia : 71 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 chronic beryllium disease 11.8
2 beryllium disease 11.7
3 paralytic poliomyelitis 10.2 IFNG IL2
4 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG IL2
5 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL2
6 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 IFNG IL2
7 plantar wart 10.2 IFNG IL2
8 amyotrophic lateral sclerosis type 14 10.2 IFNG IL2
9 parametritis 10.2 IFNG IL2
10 spastic paraplegia 19 10.2 IFNG IL2
11 cyclosporiasis 10.2 IFNG IL2
12 elephantiasis 10.2 IFNG POMC
13 chronic thromboembolic pulmonary hypertension 10.2 IFNG IL2
14 venezuelan hemorrhagic fever 10.2 IFNG IL2
15 tularemia 10.2 IFNG IL2
16 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL2
17 microcephaly 10.2 IFNG IL2
18 strawberry gallbladder 10.1 IFNG IL2
19 oropharynx cancer 10.1 IFNG IL2
20 orbital osteomyelitis 10.1 IFNG IL2
21 janus kinase-3 deficiency 10.1 IFNG IL2
22 autosomal recessive congenital methemoglobinemia 10.1 IFNG IL2
23 generalized anxiety disorder 10.1 IL2 POMC
24 myiasis 10.1 IFNG IL2
25 nasopharyngitis 10.1 IFNG IL2
26 causalgia 10.1 IFNG IL2
27 mansonelliasis 10.1 IFNG IL2
28 albinism 10.1 HLA-DRB1 IFNG
29 eye carcinoma in situ 10.1 IFNG IL2
30 retinal ischemia 10.1 IFNG IL2
31 tracheitis 10.1 IFNG IL2
32 myofibroma 10.1 HLA-DRB1 IFNG
33 periodontosis 10.1 IFNG IL2
34 acanthoma 10.1 HLA-DRB1 IFNG
35 kcnq3-related disorders 10.1 IFNG IL2
36 pancreatic signet ring cell adenocarcinoma 10.1 HLA-DRB1 IFNG
37 thyroid hyalinizing trabecular adenoma 10.1 IFNG IL2
38 bickerstaff brainstem encephalitis 10.1 HLA-DRB1 IFNG
39 hereditary alpha tryptasemia syndrome 10.1 HLA-DRB1 IFNG
40 autoimmune hemolytic anemia 10.1 IFNG IL2
41 benign deep fibrous histiocytoma 10.1 HLA-DRB1 IFNG
42 dengue hemorrhagic fever 10.1 IFNG IL2
43 plummer's disease 10.1 HLA-DRB1 IFNG
44 anterior foramen magnum meningioma 10.1 IFNG IL2
45 liver inflammatory pseudotumor 10.1 IFNG IL2
46 disease of mental health 10.1 HLA-DRB1 IFNG
47 renal agenesis meningomyelocele mullerian defect 10.1 HLA-DRB1 IL2
48 blue toe syndrome 10.1 IFNG IL2
49 nonspecific interstitial pneumonia 10.1 IFNG IL2
50 stiff-person syndrome 10.1 HLA-DRB1 IFNG

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Analgesics Phase 1, Phase 2
3 Analgesics, Non-Narcotic Phase 1, Phase 2
4 Anti-Inflammatory Agents Phase 1, Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
6 Antirheumatic Agents Phase 1, Phase 2
7 Mesalamine Phase 1, Phase 2 89-57-6
8 Peripheral Nervous System Agents Phase 1, Phase 2
9 Dermatologic Agents Phase 1, Phase 2
10 Gastrointestinal Agents Phase 1, Phase 2
11
Heparin Approved, Investigational 9005-49-6 772 46507594
12 calcium heparin
13 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2
2 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2
3 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
4 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

MalaCards organs/tissues related to Berylliosis:

39
Lung, T Cells, Testes, Monocytes, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Berylliosis:

18
Lungs

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 73)
id Title Authors Year
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. ( 19191908 )
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. ( 15778396 )
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. ( 16098233 )
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. ( 16315779 )
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. ( 11423174 )
2001
6
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. ( 11405518 )
2001
7
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. ( 10954202 )
2000
8
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. ( 9877510 )
1998
9
Interaction of genetic and exposure factors in the prevalence of berylliosis. ( 9258386 )
1997
10
Beryllium induces IL-2 and IFN-gamma in berylliosis. ( 8977230 )
1997
11
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. ( 9230733 )
1997
12
Chronic berylliosis of the lung: report of a case. ( 16892748 )
1996
13
The computed tomographic appearances in chronic berylliosis. ( 8428413 )
1993
14
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. ( 1599873 )
1992
15
Berylliosis. ( 2138073 )
1990
16
A study of immunological indices for diagnosis of chronic berylliosis. ( 2604898 )
1989
17
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. ( 3168359 )
1988
18
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. ( 3328191 )
1987
19
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. ( 7103279 )
1982
20
Inhalant granulomas: silicosis, asbestosis, berylliosis. ( 7133715 )
1982
21
Pulmonary berylliosis: report on a fatal case. ( 7126443 )
1982
22
Berylliosis. ( 7381961 )
1980
23
Non-bony uptake of technetium-99m MDP in berylliosis. ( 7437734 )
1980
24
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. ( 436529 )
1979
25
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. ( 159411 )
1979
26
Experimental aerogenic pulmonary berylliosis in rabbits. ( 147415 )
1978
27
Concentration of immunoglobulins in berylliosis. ( 564365 )
1977
28
Berylliosis as an auto-immune disorder. ( 942183 )
1976
29
Research into what happens in berylliosis. ( 1048889 )
1976
30
Case report. Pulmonary berylliosis following exposure to beryllium-copper. ( 1063889 )
1976
31
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. ( 4533844 )
1974
32
Chronic berylliosis. ( 4526035 )
1974
33
A study of the immunologic aspects of chronic berylliosis. ( 4690875 )
1973
34
Immunologic aspects of chronic berylliosis. ( 4540228 )
1973
35
Chronic berylliosis. ( 4274186 )
1973
36
Immunity to pulmonary berylliosis in guinea pigs. ( 5036157 )
1972
37
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. ( 5061834 )
1972
38
Immunoglobulin concentrationsn berylliosis. ( 4191591 )
1970
39
Immunoglobulin levels in berylliosis. ( 4129664 )
1970
40
The role of immunologic reactions in pulmonary berylliosis. ( 5527729 )
1970
41
Serological reactions of berylliosis patients to extracts of lung tissue. ( 5644743 )
1968
42
Pulmonary berylliosis: a case report. ( 6083249 )
1967
43
Chronic berylliosis and calcospherite deposition. ( 5901642 )
1966
44
PROBABLE BERYLLIOSIS FROM BERYLLIUM ALLOYS. ( 14185553 )
1964
45
Berylliosis: report of two cases, with special reference to the patch test. ( 13938965 )
1963
46
The mineral content of the lung in chronic berylliosis. ( 13991590 )
1962
47
Chronic berylliosis. ( 14498247 )
1962
48
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. ( 13761591 )
1961
49
Chronic pulmonary berylliosis in a female chemist. ( 13773748 )
1961
50
Berylliosis, bones, and behavior: an illustrative case report. ( 13738917 )
1960

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 33)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
2
Show member pathways
12.88 HLA-DPB1 HLA-DRB1 IFNG IL2 POMC
3
Show member pathways
12.52 HLA-DPB1 HLA-DRB1 IFNG IL2
4
Show member pathways
12.43 HLA-DPB1 HLA-DRB1 IFNG IL2
5
Show member pathways
12.23 HLA-DPB1 HLA-DRB1 IFNG
6 12.13 HLA-DPB1 HLA-DRB1 IL2
7
Show member pathways
12.12 HLA-DPB1 HLA-DRB1 IFNG IL2
8 12.01 HLA-DPB1 HLA-DRB1 IFNG
9
Show member pathways
11.99 HLA-DPB1 HLA-DRB1 IFNG IL2
10
Show member pathways
11.96 HLA-DPB1 HLA-DRB1 IFNG
11 11.92 HLA-DPB1 HLA-DRB1 IFNG
12
Show member pathways
11.69 HLA-DRB1 IFNG IL2
13 11.67 HLA-DPB1 HLA-DRB1
14 11.64 HLA-DPB1 HLA-DRB1
15 11.62 IL2 POMC
16 11.55 IFNG IL2
17 11.53 HLA-DPB1 HLA-DRB1 IFNG
18
Show member pathways
11.52 IFNG IL2
19 11.51 IFNG IL2
20 11.45 IFNG IL2
21 11.44 IFNG IL2
22
Show member pathways
11.42 IFNG IL2
23 11.41 IFNG IL2 POMC
24
Show member pathways
11.4 IFNG IL2
25 11.35 HLA-DPB1 HLA-DRB1
26 11.31 IFNG IL2
27 11.27 IFNG IL2
28 11.26 IFNG IL2
29
Show member pathways
11.18 IFNG IL2
30 11.08 IFNG IL2
31 10.95 IFNG IL2
32 10.61 HLA-DRB1 IFNG IL2
33 10.25 HLA-DRB1 IFNG IL2

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.4 HLA-DPB1 HLA-DRB1
2 endocytic vesicle membrane GO:0030666 9.37 HLA-DPB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DPB1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.26 HLA-DPB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DPB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DPB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.62 HLA-DPB1 HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.65 HLA-DPB1 HLA-DRB1 IL2
2 immune response GO:0006955 9.56 HLA-DPB1 HLA-DRB1 IFNG IL2
3 T cell receptor signaling pathway GO:0050852 9.54 HLA-DPB1 HLA-DRB1 IFNG
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.51 HLA-DPB1 HLA-DRB1
5 T cell costimulation GO:0031295 9.49 HLA-DPB1 HLA-DRB1
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IFNG IL2
7 positive regulation of interferon-gamma production GO:0032729 9.43 HLA-DPB1 IL2
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DPB1 HLA-DRB1
9 interferon-gamma-mediated signaling pathway GO:0060333 9.33 HLA-DPB1 HLA-DRB1 IFNG
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 IFNG IL2
11 positive regulation of T cell proliferation GO:0042102 9.13 HLA-DPB1 IFNG IL2
12 antigen processing and presentation GO:0019882 8.8 HLA-DPB1 HLA-DRB1 IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DPB1 HLA-DRB1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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