MCID: BRY001
MIFTS: 42

Berylliosis malady

Respiratory diseases, Rare diseases categories

Aliases & Classifications for Berylliosis

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Aliases & Descriptions for Berylliosis:

Name: Berylliosis 10 12 36
Subacute Berylliosis 65
 
Beryllium Poisoning 10
Acute Berylliosis 65


Classifications:



External Ids:

Disease Ontology10 DOID:10322
MeSH36 D001607
SNOMED-CT59 8247009
ICD1027 J63.2

Summaries for Berylliosis

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Disease Ontology:10 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as subacute berylliosis, is related to pneumoconiosis and chronic berylliosis. An important gene associated with Berylliosis is IFNG (Interferon, Gamma), and among its related pathways are Glucocorticoid receptor regulatory network and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include lungs, lung and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Related Diseases for Berylliosis

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Diseases in the Berylliosis family:

Chronic Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis30.5IFNG, IL2, TNF
2chronic berylliosis10.7
3post-infectious myocarditis10.4HLA-DPA1, HLA-DPB1
4beryllium disease10.4
5chromosome 8-derived supernumerary ring /marker10.4HLA-DPB1, IFNG
6visceral neuropathy familial10.3IL2, IL2RB
7tucker syndrome10.3HLA-DQB1, HLA-DRB1
8intellectual disability-obesity-prognathism-eye and skin anomalies syndrome10.3HLA-DQB1, IFNG
9interstitial keratitis10.3HLA-DRB1, IFNG, IL2
10separation anxiety disorder10.3CD4, IL2
11testicular monophasic choriocarcinoma10.3HLA-DQB1, HLA-DRB1
12hepatic tuberculosis10.3IL2, TNF
13silicosis10.3
14red cell phospholipid defect with hemolysis10.3HLA-DQB1, HLA-DRB1, IL2
15pulmonary nodular lymphoid hyperplasia10.3HLA-DQB1, HLA-DRB1, IFNG
16benign paroxysmal positional nystagmus10.3CTSA, TNF
17lichen planus pemphigoides10.3HLA-DQB1, HLA-DRB1
18stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IFNG, TNF
19lens subluxation10.3CD4, HLA-DRB1
20tibial neuropathy10.3HLA-DRB1, IFNG, IL2
21heavy chain deposition disease10.3HLA-DQB1, HLA-DRB1
22endometrial adenocarcinoma10.3IL2, IL2RB, POMC
23alternating esotropia10.3CD4, IFNG, IL2
24opisthorchiasis10.3IFNG, IL2, TNF
25hypobetalipoproteinaemia ataxia hearing loss10.3ACE, POMC
26shipyard eye10.3CD4, IFNG, POMC
27neonatal thyrotoxicosis10.3IFNG, IL2, TNF
28histidinemia10.3HLA-DQB1, HLA-DRB1, POMC
29hyperinsulinemic hypoglycemia10.3CD4, IFNG, IL2
30autoimmune oophoritis10.3IFNG, TNF
31irf6-related disorders10.3CD4, IFNG, IL2
32hemolytic anemia10.3IFNG, IL2, TNF
33powassan encephalitis10.3IFNG, IL2, TNF
34acute leukemia of ambiguous lineage10.3IFNG, IL2, TNF
35herpangina10.3IFNG, IL2, TNF
36congenital nasal pyriform aperture stenosis with holoprosencephaly10.2ACE, TNF
37spotted fever10.2IFNG, IL2, TNF
38ectropion10.2HLA-DRB1, IFNG, TNF
39hemorrhoid10.2HLA-DRB1, IFNG, TNF
40microsomia hemifacial radial defects10.2HLA-DQB1, HLA-DRB1, TNF
41bubonic plague10.2IFNG, IL2, TNF
42congenital coronary artery aneurysm10.2CD4, POMC
43soft palate cancer10.2IFNG, IL2, TNF
44cd3delta deficiency10.2HLA-DRB1, IFNG, TNF
45splenic sequestration10.2IFNG, IL2, TNF
46bullous retinoschisis10.2ACE, TNF
47focal chorioretinitis10.2IFNG, IL2, TNF
48human spumaretrovirus infection10.2HLA-DQB1, HLA-DRB1, IFNG, IL2
49moderately severe hemophilia a10.2HLA-DQB1, HLA-DRB1, TNF
50degenerative disc disease10.2IFNG, IL2, TNF

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
InfliximabapprovedPhase 1, Phase 2327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
2MesalaminePhase 1, Phase 214689-57-6
3
Acetylcysteineapproved280616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
 
Flumucetin
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Mercapturic acid
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
Sodium 2-acetamido-3-mercaptopropionate
4
Heparinapproved, investigational6729005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
5N-monoacetylcystine280
6Expectorants320
7calcium heparin672
8cysteineNutraceutical143

Interventional clinical trials:

idNameStatusNCT IDPhase
1Targeting Oxidative Stress in Chronic Beryllium DiseaseCompletedNCT01088243Phase 1, Phase 2
2Beryllium Infliximab Study: Clinical Interventional TrialTerminatedNCT00111917Phase 1, Phase 2
3Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and SarcoidosisCompletedNCT00560989
4The Effect of an Oral Antioxidant, N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary SarcoidosisCompletedNCT01587001
5The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)RecruitingNCT02596347
6Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)RecruitingNCT02604693

Search NIH Clinical Center for Berylliosis


Cochrane evidence based reviews: Berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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MalaCards organs/tissues related to Berylliosis:

33
Lung, T cells, Testes, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

16
Lungs

Animal Models for Berylliosis or affiliated genes

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MGI Mouse Phenotypes related to Berylliosis:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5ALPL, CTSA, CTSK, GBA, HLA-DQB1, IFNG
2MP:00053818.5ALPL, CD4, HGS, HLA-DQB1, IFNG, IL2
3MP:00053708.4ACE, CTSA, GBA, HLA-DQB1, IFNG, IL2
4MP:00053797.9ACE, ALPL, CTSK, HLA-DQB1, IFNG, IL2
5MP:00053767.7ACE, ALPL, CD4, CTSA, CTSK, GBA
6MP:00053857.6ACE, ALPL, CTSA, GBA, HGS, HLA-DQB1
7MP:00053866.9ACE, ALPL, CTSA, GBA, HGS, HLA-DQB1
8MP:00053846.7ACE, ALPL, CD4, CTSA, CTSK, GBA
9MP:00053896.7ACE, ALPL, ALPP, CTSA, HGS, HLA-DQB1
10MP:00053876.7ACE, ALPL, CD4, CTSA, CTSK, GBA
11MP:00053976.6ACE, ALPL, CD4, CTSA, CTSK, GBA
12MP:00107686.4ACE, ALPL, ALPP, CD4, CTSA, GBA
13MP:00053786.1ACE, ALPL, ALPP, CD4, CTSA, CTSK

Publications for Berylliosis

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Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
7
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
8
Chronic berylliosis of the lung: report of a case. (16892748)
1996
9
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
10
Berylliosis. (2138073)
1990
11
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
12
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
13
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
14
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
15
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
16
Berylliosis. (7381961)
1980
17
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
18
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
19
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
20
Research into what happens in berylliosis. (1048889)
1976
21
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
22
Chronic berylliosis. (4274186)
1973
23
Immunologic aspects of chronic berylliosis. (4540228)
1973
24
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
25
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
26
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
27
Immunoglobulin levels in berylliosis. (4129664)
1970
28
Pulmonary berylliosis: a case report. (6083249)
1967
29
Chronic berylliosis and calcospherite deposition. (5901642)
1966
30
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
31
Chronic berylliosis. (14498247)
1962
32
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
33
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
34
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
35
Beryllium and berylliosis. (13580272)
1958
36
Berylliosis. (14371570)
1955
37
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
38
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
39
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
40
Chronic berylliosis in the neon sign industry. (14837525)
1951
41
Berylliosis and silicosis. (14841360)
1951
42
Some aspects of berylliosis. (14819024)
1951
43
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Berylliosis. (14771889)
1950
46
Non-occupational berylliosis. (18141686)
1949
47
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
48
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
49
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948
50
Berylliosis. (18102274)
1948

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL2, POMC
29.8IFNG, IL2, TNF
3
Show member pathways
9.8IFNG, IL2, TNF
49.7CD4, HLA-DRB1, TNF
59.6CD4, HLA-DRB1, IFNG, IL2
69.6IFNG, IL2, IL2RB
7
Show member pathways
9.5CD4, IFNG, IL2, TNF
89.4HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
99.3CD4, HLA-DRB1, IFNG, IL2, TNF
109.3CD4, HLA-DPA1, HLA-DQB1, HLA-DRB1
11
Show member pathways
9.3IFNG, IL2, IL2RB, TNF
12
Show member pathways
9.3IFNG, IL2, IL2RB, TNF
139.2ALPL, ALPP, ALPPL2
14
Show member pathways
9.2ALPL, ALPP, ALPPL2
15
Show member pathways
9.2HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
169.2HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
179.2CD4, HGS, HLA-DRB1
18
TCR signaling (REACTOME)
Show member pathways
9.1CD4, HGS, HLA-DRB1
19
Show member pathways
9.1CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
20
Show member pathways
9.1CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
21
Show member pathways
9.1CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
229.1CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
23
Show member pathways
9.1CD4, HLA-DRB1, IFNG, IL2, IL2RB
249.0CD4, IFNG, IL2, IL2RB, TNF
258.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG, TNF
26
Show member pathways
8.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG, TNF
27
TNF Signaling (sino)
Show member pathways
8.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG, TNF
288.8CTSA, CTSK, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
298.6CTSK, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
30
Show member pathways
8.6CD4, HLA-DPA1, HLA-DQB1, HLA-DRB1, IL2, IL2RB
318.6HGS, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
32
Show member pathways
8.4CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
33
Show member pathways
8.4CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL2
34
Show member pathways
8.4HLA-DPA1, HLA-DQB1, HLA-DRB1, IFNG, IL2, IL2RB
358.4HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL2, IL2RB
36
Show member pathways
8.2HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG, IL2
37
Show member pathways
7.0CD4, CTSA, CTSK, HLA-DPA1, HLA-DPB1, HLA-DQB1

GO Terms for genes affiliated with Berylliosis

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Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.0HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.0HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
4endocytic vesicle membraneGO:00306669.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
5clathrin-coated endocytic vesicle membraneGO:00306699.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:00325889.9HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
7transport vesicle membraneGO:00306589.8HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
8lysosomal membraneGO:00057659.4GBA, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
9external side of plasma membraneGO:00098979.2ACE, CD4, HLA-DRB1, IFNG, IL2RB, TNF
10extracellular spaceGO:00056158.7ACE, ALPL, CTSK, IFNG, IL2, POMC
11cell surfaceGO:00099868.4ALPP, CD4, HLA-DPA1, HLA-DPB1, HLA-DRB1, TNF
12plasma membraneGO:00058866.3ACE, ALPL, ALPP, ALPPL2, CD4, HLA-DPA1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.7IFNG, TNF
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.6HLA-DQB1, HLA-DRB1
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IFNG, TNF
4humoral immune response mediated by circulating immunoglobulinGO:000245510.6HLA-DQB1, HLA-DRB1
5positive regulation of chemokine biosynthetic processGO:004508010.6IFNG, TNF
6positive regulation of isotype switching to IgG isotypesGO:004830410.5IFNG, IL2
7antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.0HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
8positive regulation of T cell activationGO:00508709.9CD4, HLA-DPA1, HLA-DPB1
9positive regulation of interferon-gamma productionGO:00327299.9HLA-DPA1, HLA-DPB1, IL2, TNF
10response to glucocorticoidGO:00513849.8ALPL, GBA, TNF
11interferon-gamma-mediated signaling pathwayGO:00603339.7HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
12antigen processing and presentationGO:00198829.6HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG
13T cell costimulationGO:00312959.5CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
14T cell receptor signaling pathwayGO:00508529.5CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
15antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.5HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
16positive regulation of T cell proliferationGO:00421029.3HLA-DPA1, HLA-DPB1, IFNG, IL2
17cytokine-mediated signaling pathwayGO:00192218.7HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG, IL2RB
18immune responseGO:00069558.0CD4, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.8HLA-DPA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426059.4HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1
3alkaline phosphatase activityGO:00040359.1ALPL, ALPP, ALPPL2

Sources for Berylliosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet