MCID: BRY001
MIFTS: 47

Berylliosis malady

Respiratory diseases category

Summaries for Berylliosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and hypertension. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are Cytokines and Inflammatory Response and IL2 signaling events mediated by PI3K. The compounds prednisolone and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and testes, and related mouse phenotype liver/biliary system.

Wikipedia:63 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Aliases & Classifications for Berylliosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

berylliosis 8 42
subacute berylliosis 42 60
acute berylliosis 42 60
chronic pulmonary berylliosis 42
reversible berylliosis 42
beryllium poisoning 8


External Ids:

Disease Ontology8 DOID:10322
MeSH34 D001607
SNOMED-CT56 8247009
ICD1025 J63.2

Related Diseases for Berylliosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Clinical Features for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Berylliosis

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Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Berylliosis:

32
Lung, Testes, T cells, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

14
Lungs

Animal Models for Berylliosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Berylliosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2ALB, IL2, IL2RB, IFNG

Publications for Berylliosis

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50PubMed
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Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (11405518)
2001
7
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. (10954202)
2000
8
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
9
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
10
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
11
Interaction of genetic and exposure factors in the prevalence of berylliosis. (9258386)
1997
12
The computed tomographic appearances in chronic berylliosis. (8428413)
1993
13
Berylliosis. (2138073)
1990
14
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
15
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
16
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
17
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
18
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
19
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. (159411)
1979
20
Experimental aerogenic pulmonary berylliosis in rabbits. (147415)
1978
21
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
22
Research into what happens in berylliosis. (1048889)
1976
23
Chronic berylliosis. (4526035)
1974
24
Chronic berylliosis. (4274186)
1973
25
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
26
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
27
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
28
Immunoglobulin levels in berylliosis. (4129664)
1970
29
The role of immunologic reactions in pulmonary berylliosis. (5527729)
1970
30
PROBABLE BERYLLIOSIS FROM BERYLLIUM ALLOYS. (14185553)
1964
31
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
32
Chronic berylliosis. (14498247)
1962
33
The mineral content of the lung in chronic berylliosis. (13991590)
1962
34
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
35
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
36
Beryllium and berylliosis. (13580272)
1958
37
BERYLLIOSIS. (13316118)
1956
38
Berylliosis. (14371570)
1955
39
Berylliosis: a case report. (14378588)
1955
40
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
41
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
42
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
43
Berylliosis; a new disease. (14933466)
1952
44
Berylliosis; case report. (14958532)
1952
45
Chronic berylliosis in the neon sign industry. (14837525)
1951
46
Some aspects of berylliosis. (14819024)
1951
47
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
48
Berylliosis. (14771889)
1950
49
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
50
Berylliosis. (18102274)
1948

Genetic Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 53Reactome
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Pathways related to Berylliosis according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-DRB1
2
Hide members
9.7IL2, IL2RB
39.5HLA-DPB1, HLA-DPA1
49.5IFNG, IL2
5
Hide members
9.5IL2, IFNG
69.5IL2, IFNG
79.5IL2, IFNG
89.1IFNG, IL2RB, IL2
99.1IFNG, IL2RB, IL2
10
Hide members
9.1IFNG, IL2RB, IL2
11
Hide members
9.1IFNG, IL2RB, IL2
129.1IFNG, IL2RB, IL2
139.0HLA-DPA1, HLA-DPB1, HLA-DRB1
14
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
15
Immune response ICOS pathway in T-helper cell
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9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
169.0HLA-DRB1, HLA-DPB1, HLA-DPA1
17
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
189.0HLA-DRB1, HLA-DPB1, HLA-DPA1
199.0HLA-DRB1, HLA-DPB1, HLA-DPA1
20
Immune response NFAT in immune response
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9.0HLA-DPA1, HLA-DPB1, HLA-DRB1
219.0HLA-DRB1, HLA-DPB1, HLA-DPA1
22
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
239.0HLA-DRB1, HLA-DPB1, HLA-DPA1
24
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
25
Immune response Antigen presentation by MHC class II
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9.0HLA-DPA1, HLA-DPB1, HLA-DRB1
269.0IL2, HLA-DRB1, IFNG
27
Hide members
8.6IL2, IL2RB, HLA-DRB1, HLA-DPA1
28
Hide members
8.5IFNG, HLA-DRB1, IL2RB, IL2
29
Hide members
8.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
308.4IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1
318.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
32
Hide members
8.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
338.2HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
348.2IL2, IL2RB, HLA-DRB1, HLA-DPB1, HLA-DPA1
35
Hide members
8.0IL2, IL2RB, HLA-DRB1, HLA-DPA1, IFNG
36
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
37
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
38
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2

Compounds for genes affiliated with Berylliosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Berylliosis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.5IL2RB
2pentoxifylline44 1111.5IL2RB
3r-il-24410.1IL2, IL2RB
4denileukin diftitox44 49 1112.1IL2, IL2RB
5ctla4-ig4410.1IL2, IL2RB
6daclizumab44 1111.0IL2RB, IL2
7basiliximab44 1111.0IL2, IL2RB
8alemtuzumab44 1111.0IL2, IL2RB
9levamisole44 1111.0IL2RB, IL2
10chromium449.9IL2RB, IL2
11interferon gamma449.9IFNG, IL2
12gm-csf44 2810.9IFNG
13bucillamine449.8IL2, IFNG
14alpha-galactosylceramide449.8IFNG, IL2
15taurine chloramine449.8IL2, IFNG
16fumarate44 1110.8IFNG, IL2
17il-12449.7IL2, IFNG
18zoledronic acid449.6IL2, IFNG
19piroxicam44 1110.6ALB, IL2
20sulfamethoxazole44 49 1111.6IL2, ALB
21triptolide449.5IFNG, IL2
22okt3449.5IL2, IL2RB, IFNG
23con a449.5IFNG, IL2RB, IL2
242,5-oligoadenylate449.5IL2, IL2RB, IFNG
25il 10449.5IL2, IL2RB, IFNG
26ifn-alpha449.5IL2, IL2RB, IFNG
27neopterin449.5IL2, IL2RB, IFNG
28etanercept44 49 1111.4IL2RB, IFNG
29ionomycin449.4IL2, IL2RB, IFNG
30dpa 1449.4HLA-DRB1, HLA-DPB1, HLA-DPA1
31glatiramer acetate44 1110.4IFNG, HLA-DRB1, IL2
32gold sodium thiomalate449.4IFNG, HLA-DRB1, IL2
33polysulfone449.4ALB, IL2RB
34mycophenolic acid44 49 1111.3ALB, IL2, IL2RB
35aminoguanidine44 28 1111.3IFNG, ALB
36naloxone44 49 28 1112.3IL2RB, IL2, ALB
37rantes449.3IL2, IL2RB, IFNG
38l-tryptophan44 28 11 2412.2IFNG, ALB
39polyinosinic-polycytidylic acid449.2IL2, IFNG
40ivig449.0IFNG, IL2RB, ALB
41methotrexate44 49 1111.0ALB, IL2RB, HLA-DRB1
42calcitriol44 59 11 2412.0IFNG, IL2, ALB
43rapamycin449.0IL2, IL2RB, IFNG
44auranofin44 59 28 1111.7ALB, IL2, IL2RB, IFNG
45mycophenolate mofetil44 49 1110.7IFNG, IL2RB, IL2, ALB
46tacrolimus44 49 1110.7IFNG, IL2RB, IL2, ALB
47histamine44 28 2410.6IFNG, IL2RB, IL2, ALB

GO Terms for genes affiliated with Berylliosis

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16Gene Ontology
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Cellular components related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.2HLA-DRB1, HLA-DPB1, HLA-DPA1
2clathrin-coated endocytic vesicle membraneGO:0306699.2HLA-DRB1, HLA-DPB1, HLA-DPA1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.1HLA-DPA1, HLA-DPB1, HLA-DRB1
4transport vesicle membraneGO:0306589.1HLA-DPA1, HLA-DPB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.0HLA-DPA1, HLA-DPB1, HLA-DRB1
6trans-Golgi network membraneGO:0325889.0HLA-DRB1, HLA-DPB1, HLA-DPA1
7lysosomal membraneGO:0057659.0HLA-DRB1, HLA-DPB1, HLA-DPA1
8endocytic vesicle membraneGO:0306668.9HLA-DPA1, HLA-DPB1, HLA-DRB1
9external side of plasma membraneGO:0098978.6IL2RB, HLA-DRB1, IFNG

Biological processes related to Berylliosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:0483049.5IL2, IFNG
2immune responseGO:0069559.1IL2, HLA-DRB1, HLA-DPA1
3T cell costimulationGO:0312959.0HLA-DPA1, HLA-DPB1, HLA-DRB1
4T cell receptor signaling pathwayGO:0508528.9HLA-DRB1, HLA-DPB1, HLA-DPA1
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.7HLA-DPA1, HLA-DPB1, HLA-DRB1
6interferon-gamma-mediated signaling pathwayGO:0603338.5IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1
7cytokine-mediated signaling pathwayGO:0192218.1IL2RB, HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG

Molecular functions related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.4HLA-DRB1, HLA-DPA1

Products for genes affiliated with Berylliosis

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Sources for Berylliosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet