MCID: BRY001
MIFTS: 40

Berylliosis malady

Respiratory category

Summaries for Berylliosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and silicosis. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are Cytokines and Inflammatory Response and IL2 signaling events mediated by PI3K. The compounds prednisolone and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and monocytes, and related mouse phenotype liver/biliary system.

Wikipedia:64 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Aliases & Classifications for Berylliosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

berylliosis 8 43
subacute berylliosis 43 61
acute berylliosis 43 61
chronic pulmonary berylliosis 43
reversible berylliosis 43
beryllium poisoning 8


External Ids:

Disease Ontology8 DOID:10322
MeSH35 D001607
SNOMED-CT57 8247009
ICD1025 J63.2

Related Diseases for Berylliosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Clinical Features for Berylliosis

Drugs & Therapeutics for Berylliosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Berylliosis

Drug clinical trials:

Search ClinicalTrials for Berylliosis

Search NIH Clinical Center for Berylliosis

Search CenterWatch for Berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Berylliosis:

33
Lung, Monocytes, T cells

FMA organs/tissues related to Berylliosis:

14
Lungs

Animal Models for Berylliosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Berylliosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2ALB, IL2, IL2RB, IFNG

Publications for Berylliosis

Sources:
51PubMed
See all sources

Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
4
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. (10954202)
2000
5
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
6
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
7
Interaction of genetic and exposure factors in the prevalence of berylliosis. (9258386)
1997
8
Chronic berylliosis of the lung: report of a case. (16892748)
1996
9
The computed tomographic appearances in chronic berylliosis. (8428413)
1993
10
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
11
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
12
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. (3168359)
1988
13
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
14
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
15
Berylliosis. (7381961)
1980
16
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
17
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
18
Experimental aerogenic pulmonary berylliosis in rabbits. (147415)
1978
19
Concentration of immunoglobulins in berylliosis. (564365)
1977
20
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
21
Berylliosis as an auto-immune disorder. (942183)
1976
22
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
23
Immunologic aspects of chronic berylliosis. (4540228)
1973
24
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. (5061834)
1972
25
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
26
Serological reactions of berylliosis patients to extracts of lung tissue. (5644743)
1968
27
Pulmonary berylliosis: a case report. (6083249)
1967
28
Chronic berylliosis and calcospherite deposition. (5901642)
1966
29
The mineral content of the lung in chronic berylliosis. (13991590)
1962
30
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
31
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. (13761591)
1961
32
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
33
Beryllium and berylliosis. (13580272)
1958
34
BERYLLIOSIS. (13316118)
1956
35
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
36
Berylliosis; a real but preventable industrial disease. (13196701)
1954
37
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
38
Berylliosis; a new disease. (14933466)
1952
39
Berylliosis: summary and survey of all clinical types in ten year period. (12979086)
1952
40
Berylliosis; case report. (14958532)
1952
41
Chronic berylliosis in the neon sign industry. (14837525)
1951
42
Berylliosis and silicosis. (14841360)
1951
43
Some aspects of berylliosis. (14819024)
1951
44
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
45
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
46
Berylliosis. (14771889)
1950
47
Non-occupational berylliosis. (18141686)
1949
48
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
49
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
50
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948

Genetic Variations for Berylliosis

Expression for genes affiliated with Berylliosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN, 53R&D Systems, 54Reactome
See all sources

Pathways related to Berylliosis according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0HLA-DRB1
2
Hide members
9.7IL2, IL2RB
39.5HLA-DPB1, HLA-DPA1
49.5IFNG, IL2
5
Hide members
9.5IL2, IFNG
69.5IL2, IFNG
79.5IL2, IFNG
89.1IFNG, IL2RB, IL2
99.1IFNG, IL2RB, IL2
10
Hide members
9.1IFNG, IL2RB, IL2
11
Hide members
9.1IFNG, IL2RB, IL2
129.1IFNG, IL2RB, IL2
139.0HLA-DPA1, HLA-DPB1, HLA-DRB1
14
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
15
Immune response ICOS pathway in T-helper cell
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
169.0HLA-DRB1, HLA-DPB1, HLA-DPA1
17
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
189.0HLA-DRB1, HLA-DPB1, HLA-DPA1
199.0HLA-DRB1, HLA-DPB1, HLA-DPA1
20
Immune response NFAT in immune response
Hide members
9.0HLA-DPA1, HLA-DPB1, HLA-DRB1
219.0HLA-DRB1, HLA-DPB1, HLA-DPA1
22
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
239.0HLA-DRB1, HLA-DPB1, HLA-DPA1
24
Hide members
9.0HLA-DRB1, HLA-DPB1, HLA-DPA1
25
Immune response Antigen presentation by MHC class II
Hide members
9.0HLA-DPA1, HLA-DPB1, HLA-DRB1
269.0IL2, HLA-DRB1, IFNG
27
Hide members
8.6IL2, IL2RB, HLA-DRB1, HLA-DPA1
28
Hide members
8.5IFNG, HLA-DRB1, IL2RB, IL2
29
Hide members
8.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
308.4IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1
318.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
32
Hide members
8.4HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG
338.2HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
348.2IL2, IL2RB, HLA-DRB1, HLA-DPB1, HLA-DPA1
35
Hide members
8.0IL2, IL2RB, HLA-DRB1, HLA-DPA1, IFNG
36
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
37
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2
38
Hide members
7.6IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1, IL2RB, IL2

Compounds for genes affiliated with Berylliosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Berylliosis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1prednisolone45 29 1112.5IL2RB
2pentoxifylline45 1111.5IL2RB
3r-il-24510.1IL2, IL2RB
4denileukin diftitox45 50 1112.1IL2, IL2RB
5ctla4-ig4510.1IL2, IL2RB
6daclizumab45 1111.0IL2RB, IL2
7basiliximab45 1111.0IL2, IL2RB
8alemtuzumab45 1111.0IL2, IL2RB
9levamisole45 1111.0IL2RB, IL2
10chromium459.9IL2RB, IL2
11interferon gamma459.9IFNG, IL2
12gm-csf45 2910.9IFNG
13bucillamine459.8IL2, IFNG
14alpha-galactosylceramide459.8IFNG, IL2
15taurine chloramine459.8IL2, IFNG
16fumarate45 1110.8IFNG, IL2
17il-12459.7IL2, IFNG
18zoledronic acid459.6IL2, IFNG
19piroxicam45 1110.6ALB, IL2
20sulfamethoxazole45 50 1111.6IL2, ALB
21triptolide459.5IFNG, IL2
22okt3459.5IL2, IL2RB, IFNG
23con a459.5IFNG, IL2RB, IL2
242,5-oligoadenylate459.5IL2, IL2RB, IFNG
25il 10459.5IL2, IL2RB, IFNG
26ifn-alpha459.5IL2, IL2RB, IFNG
27neopterin459.5IL2, IL2RB, IFNG
28etanercept45 50 1111.4IL2RB, IFNG
29ionomycin459.4IL2, IL2RB, IFNG
30dpa 1459.4HLA-DRB1, HLA-DPB1, HLA-DPA1
31glatiramer acetate45 1110.4IFNG, HLA-DRB1, IL2
32gold sodium thiomalate459.4IFNG, HLA-DRB1, IL2
33polysulfone459.4ALB, IL2RB
34mycophenolic acid45 50 1111.3ALB, IL2, IL2RB
35aminoguanidine45 29 1111.3IFNG, ALB
36naloxone45 50 29 1112.3IL2RB, IL2, ALB
37rantes459.3IL2, IL2RB, IFNG
38l-tryptophan45 29 11 2412.2IFNG, ALB
39polyinosinic-polycytidylic acid459.2IL2, IFNG
40ivig459.0IFNG, IL2RB, ALB
41methotrexate45 50 1111.0ALB, IL2RB, HLA-DRB1
42calcitriol45 60 11 2412.0IFNG, IL2, ALB
43rapamycin459.0IL2, IL2RB, IFNG
44auranofin45 60 29 1111.7ALB, IL2, IL2RB, IFNG
45mycophenolate mofetil45 50 1110.7IFNG, IL2RB, IL2, ALB
46tacrolimus45 50 1110.7IFNG, IL2RB, IL2, ALB
47histamine45 29 2410.6IFNG, IL2RB, IL2, ALB

GO Terms for genes affiliated with Berylliosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.2HLA-DRB1, HLA-DPB1, HLA-DPA1
2clathrin-coated endocytic vesicle membraneGO:0306699.2HLA-DRB1, HLA-DPB1, HLA-DPA1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.1HLA-DPA1, HLA-DPB1, HLA-DRB1
4transport vesicle membraneGO:0306589.1HLA-DPA1, HLA-DPB1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.0HLA-DPA1, HLA-DPB1, HLA-DRB1
6trans-Golgi network membraneGO:0325889.0HLA-DRB1, HLA-DPB1, HLA-DPA1
7lysosomal membraneGO:0057659.0HLA-DRB1, HLA-DPB1, HLA-DPA1
8endocytic vesicle membraneGO:0306668.9HLA-DPA1, HLA-DPB1, HLA-DRB1
9external side of plasma membraneGO:0098978.6IL2RB, HLA-DRB1, IFNG

Biological processes related to Berylliosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:0483049.5IL2, IFNG
2immune responseGO:0069559.1IL2, HLA-DRB1, HLA-DPA1
3T cell costimulationGO:0312959.0HLA-DPA1, HLA-DPB1, HLA-DRB1
4T cell receptor signaling pathwayGO:0508528.9HLA-DRB1, HLA-DPB1, HLA-DPA1
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.7HLA-DPA1, HLA-DPB1, HLA-DRB1
6interferon-gamma-mediated signaling pathwayGO:0603338.5IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1
7cytokine-mediated signaling pathwayGO:0192218.1IL2RB, HLA-DRB1, HLA-DPB1, HLA-DPA1, IFNG

Molecular functions related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.4HLA-DRB1, HLA-DPA1

Products for genes affiliated with Berylliosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Berylliosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet