MCID: BRY001
MIFTS: 42

Berylliosis

Categories: Respiratory diseases

Aliases & Classifications for Berylliosis

MalaCards integrated aliases for Berylliosis:

Name: Berylliosis 12 72 41 14
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
ICD10 32 J63.2
MeSH 41 D001607
SNOMED-CT 64 8247009
UMLS 69 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to beryllium disease and chronic beryllium disease. An important gene associated with Berylliosis is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and t cells.

Wikipedia : 72 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 beryllium disease 32.4 HLA-DPB1 HLA-DRB1
2 chronic beryllium disease 31.4 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
3 rheumatic fever 29.5 HLA-DRB1 IL2
4 posner-schlossman syndrome 10.2 HLA-DPA1 HLA-DPB1
5 allergic hypersensitivity disease 10.2
6 variola major 10.1 IFNG IL2
7 autoimmune myocarditis 10.1 IFNG IL2
8 immune suppression 10.1 IFNG IL2
9 atopic keratoconjunctivitis 10.1 IFNG IL2
10 clonorchiasis 10.1 IFNG IL2
11 crohn's colitis 10.1 IFNG IL2
12 chronic active epstein-barr virus infection 10.1 IFNG IL2
13 posterior uveitis 10.1 IFNG IL2
14 intermediate uveitis 10.1 IFNG IL2
15 vulvovaginal candidiasis 10.1 IFNG IL2
16 coccidiosis 10.1 IFNG IL2
17 erythema multiforme 10.1 IFNG IL2
18 hematopoietic stem cell transplantation 10.1 IFNG IL2
19 autoimmune disease of endocrine system 10.1 IFNG IL2
20 lepromatous leprosy 10.1 IFNG IL2
21 hypersensitivity reaction type iv disease 10.1 IFNG IL2
22 acute graft versus host disease 10.1 IFNG IL2
23 pleurisy 10.1 IFNG IL2
24 herpes zoster 10.1 IFNG IL2
25 paracoccidioidomycosis 10.1 IFNG IL2
26 vernal conjunctivitis 10.1 IFNG IL2
27 brucellosis 10.1 IFNG IL2
28 leprosy 3 10.1 IFNG IL2
29 tonsillitis 10.1 IFNG IL2
30 tropical spastic paraparesis 10.0 IFNG IL2
31 silicosis 10.0
32 human immunodeficiency virus infectious disease 10.0 IFNG IL2
33 smallpox 10.0 IFNG IL2
34 spondyloarthropathy 10.0 IFNG IL2
35 parasitic protozoa infectious disease 10.0 IFNG IL2
36 conjunctivitis 10.0 IFNG IL2
37 filariasis 10.0 IFNG IL2
38 keratoconjunctivitis 10.0 IFNG IL2
39 pulmonary sarcoidosis 10.0 IFNG IL2
40 thyroiditis 10.0 IFNG IL2
41 primary bacterial infectious disease 10.0 IFNG IL2
42 sezary's disease 10.0 IFNG IL2
43 acute disseminated encephalomyelitis 10.0 HLA-DPA1 HLA-DRB1
44 toxic shock syndrome 10.0 IFNG IL2
45 schistosomiasis 10.0 IFNG IL2
46 alopecia areata 10.0 IFNG IL2
47 lymphopenia 10.0 IFNG IL2
48 trypanosomiasis 10.0 IFNG IL2
49 asbestosis 10.0
50 asbestos intoxication 10.0

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Analgesics Phase 1, Phase 2
3 Analgesics, Non-Narcotic Phase 1, Phase 2
4 Anti-Inflammatory Agents Phase 1, Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
6 Antirheumatic Agents Phase 1, Phase 2
7 Mesalamine Phase 1, Phase 2 89-57-6
8 Peripheral Nervous System Agents Phase 1, Phase 2
9 Dermatologic Agents Phase 1, Phase 2
10 Gastrointestinal Agents Phase 1, Phase 2
11
Heparin Approved, Investigational 9005-49-6 46507594 772
12 calcium heparin
13 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
4 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

The Foundational Model of Anatomy Ontology organs/tissues related to Berylliosis:

18
Lungs

MalaCards organs/tissues related to Berylliosis:

38
Lung, T Cells, Testes, Bone, Monocytes

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 74)
# Title Authors Year
1
Berylliosis (Chronic Beryllium Disease) ( 29261866 )
2017
2
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. ( 19191908 )
2009
3
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. ( 16315779 )
2005
4
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. ( 15778396 )
2005
5
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. ( 16098233 )
2005
6
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. ( 11423174 )
2001
7
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. ( 11405518 )
2001
8
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. ( 10954202 )
2000
9
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. ( 9877510 )
1998
10
Interaction of genetic and exposure factors in the prevalence of berylliosis. ( 9258386 )
1997
11
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. ( 9230733 )
1997
12
Beryllium induces IL-2 and IFN-gamma in berylliosis. ( 8977230 )
1997
13
Chronic berylliosis of the lung: report of a case. ( 16892748 )
1996
14
The computed tomographic appearances in chronic berylliosis. ( 8428413 )
1993
15
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. ( 1599873 )
1992
16
Berylliosis. ( 2138073 )
1990
17
A study of immunological indices for diagnosis of chronic berylliosis. ( 2604898 )
1989
18
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. ( 3168359 )
1988
19
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. ( 3328191 )
1987
20
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. ( 7103279 )
1982
21
Inhalant granulomas: silicosis, asbestosis, berylliosis. ( 7133715 )
1982
22
Pulmonary berylliosis: report on a fatal case. ( 7126443 )
1982
23
Non-bony uptake of technetium-99m MDP in berylliosis. ( 7437734 )
1980
24
Berylliosis. ( 7381961 )
1980
25
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. ( 436529 )
1979
26
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. ( 159411 )
1979
27
Experimental aerogenic pulmonary berylliosis in rabbits. ( 147415 )
1978
28
Concentration of immunoglobulins in berylliosis. ( 564365 )
1977
29
Berylliosis as an auto-immune disorder. ( 942183 )
1976
30
Research into what happens in berylliosis. ( 1048889 )
1976
31
Case report. Pulmonary berylliosis following exposure to beryllium-copper. ( 1063889 )
1976
32
Chronic berylliosis. ( 4526035 )
1974
33
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. ( 4533844 )
1974
34
Chronic berylliosis. ( 4274186 )
1973
35
Immunologic aspects of chronic berylliosis. ( 4540228 )
1973
36
A study of the immunologic aspects of chronic berylliosis. ( 4690875 )
1973
37
Immunity to pulmonary berylliosis in guinea pigs. ( 5036157 )
1972
38
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. ( 5061834 )
1972
39
Immunoglobulin concentrationsn berylliosis. ( 4191591 )
1970
40
Immunoglobulin levels in berylliosis. ( 4129664 )
1970
41
The role of immunologic reactions in pulmonary berylliosis. ( 5527729 )
1970
42
Serological reactions of berylliosis patients to extracts of lung tissue. ( 5644743 )
1968
43
Pulmonary berylliosis: a case report. ( 6083249 )
1967
44
Chronic berylliosis and calcospherite deposition. ( 5901642 )
1966
45
PROBABLE BERYLLIOSIS FROM BERYLLIUM ALLOYS. ( 14185553 )
1964
46
Berylliosis: report of two cases, with special reference to the patch test. ( 13938965 )
1963
47
Chronic berylliosis. ( 14498247 )
1962
48
The mineral content of the lung in chronic berylliosis. ( 13991590 )
1962
49
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. ( 13761591 )
1961
50
Chronic pulmonary berylliosis in a female chemist. ( 13773748 )
1961

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
2
Show member pathways
13.06 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
3
Show member pathways
12.93 HLA-DPA1 HLA-DRB1 IFNG IL2
4
Show member pathways
12.46 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
5
Show member pathways
12.35 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6
Show member pathways
12.33 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
7 12.22 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
8
Show member pathways
12.18 HLA-DPA1 HLA-DRB1 IL2
9
Show member pathways
12.14 HLA-DPA1 HLA-DPB1 HLA-DRB1
10
Show member pathways
12.11 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
11 12.09 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
12
Show member pathways
12.03 HLA-DPA1 HLA-DPB1 HLA-DRB1
13
Show member pathways
12.01 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
14 11.96 HLA-DPA1 HLA-DPB1 HLA-DRB1
15 11.93 HLA-DPA1 HLA-DPB1 HLA-DRB1
16 11.92 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
17
Show member pathways
11.81 HLA-DRB1 IFNG IL2
18
Show member pathways
11.79 HLA-DPA1 HLA-DPB1 HLA-DRB1
19 11.76 HLA-DPA1 HLA-DPB1 HLA-DRB1
20 11.75 HLA-DPA1 HLA-DPB1 HLA-DRB1
21 11.72 HLA-DPA1 HLA-DPB1 HLA-DRB1
22
Show member pathways
11.7 IFNG IL2
23
Show member pathways
11.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
24 11.6 IFNG IL2
25 11.58 IFNG IL2
26
Show member pathways
11.56 IFNG IL2
27
Show member pathways
11.56 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
28 11.54 IFNG IL2
29 11.52 HLA-DPA1 HLA-DRB1
30 11.49 IFNG IL2
31
Show member pathways
11.46 IFNG IL2
32 11.45 HLA-DPA1 HLA-DPB1 HLA-DRB1
33
Show member pathways
11.44 IFNG IL2
34 11.36 IFNG IL2
35 11.33 IFNG IL2
36 11.31 IFNG IL2
37 11.21 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
38
Show member pathways
11.19 IFNG IL2
39 11.15 IFNG IL2
40 11.11 HLA-DRB1 IFNG IL2
41 11.04 IFNG IL2
42 11.03 HLA-DRB1 IFNG IL2

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.7 HLA-DPA1 HLA-DPB1 HLA-DRB1
2 Golgi membrane GO:0000139 9.69 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 cell surface GO:0009986 9.67 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 lysosome GO:0005764 9.65 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 lysosomal membrane GO:0005765 9.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
6 endosome membrane GO:0010008 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
7 trans-Golgi network membrane GO:0032588 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.54 HLA-DPA1 HLA-DPB1 HLA-DRB1
9 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
10 transport vesicle membrane GO:0030658 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
13 MHC class II protein complex GO:0042613 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.76 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
2 T cell receptor signaling pathway GO:0050852 9.65 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 T cell costimulation GO:0031295 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 immune response GO:0006955 9.55 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6 positive regulation of T cell proliferation GO:0042102 9.54 HLA-DPA1 HLA-DPB1 IL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNG IL2
8 positive regulation of T cell activation GO:0050870 9.51 HLA-DPA1 HLA-DPB1
9 positive regulation of interferon-gamma production GO:0032729 9.5 HLA-DPA1 HLA-DPB1 IL2
10 regulation of regulatory T cell differentiation GO:0045589 9.49 IFNG IL2
11 antigen processing and presentation GO:0019882 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
13 interferon-gamma-mediated signaling pathway GO:0060333 8.92 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DPA1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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