MCID: BRY001
MIFTS: 43

Berylliosis malady

Rare diseases, Respiratory diseases categories

Aliases & Classifications for Berylliosis

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Berylliosis, Aliases & Descriptions:

Name: Berylliosis 9 41
Subacute Berylliosis 41 60
Acute Berylliosis 41 60
 
Chronic Pulmonary Berylliosis 41
Reversible Berylliosis 41
Beryllium Poisoning 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:10322
MeSH33 D001607
SNOMED-CT55 8247009
ICD1025 J63.2

Summaries for Berylliosis

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Disease Ontology:9 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and capillary leak syndrome. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are Immune response IL 2 activation and signaling pathway and IL2 signaling events mediated by PI3K. The compounds r-il-2 and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and testes, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:63 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

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Diseases in the Berylliosis family:

Chronic Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1chronic berylliosis10.7
2capillary leak syndrome10.5IL2
3ulcerative colitis10.4ALB
4thyroiditis10.4HLA-DRB1
5silicosis10.3
6complete atrioventricular canal10.3
7t-cell large granular lymphocyte leukemia10.2IL2, IL2RB
8severe combined immunodeficiency, x-linked10.2IL2, IL2RB
9common variable immunodeficiency10.2IL2, IL2RB
10hcl-v10.2IL2, IL2RB
11leprosy10.2IL2, HLA-DRB1
12uveitis10.2IFNG
13mycosis fungoides10.2IL2RB, IL2
14acquired immunodeficiency syndrome10.2IL2, ALB
15asbestosis10.2
16lipoid nephrosis10.2IL2RB, ALB
17leukopenia10.2IL2, ALB
18kidney cancer10.2IL2, IL2RB
19cork-handlers' disease10.2ALB, IL2
20diphtheria10.1IL2RB, IL2
21polymyalgia rheumatica10.1HLA-DRB1, IL2RB
22diarrhea10.1ALB, IL2
23juvenile rheumatoid arthritis10.1HLA-DRB1, IL2RB
24lepromatous leprosy10.1IL2, IFNG
25nutritional deficiency disease10.1IL2RB, ALB
26chronic lymphocytic leukemia10.1IL2RB, IL2
27toxic shock syndrome10.1IL2, IFNG
28factor vii deficiency10.1IL2, IFNG
29myasthenia gravis10.1IFNG, IL2
30pulmonary hypertension10.0
31rheumatic fever10.0
32pneumoconiosis10.0
33precursor t-cell acute lymphoblastic leukemia10.0IL2, IL2RB
34diabetes mellitus, insulin-dependent10.0IFNG, HLA-DRB1
35plasmodium falciparum malaria10.0HLA-DRB1, IFNG
36skin disease10.0IL2, HLA-DRB1, ALB
37connective tissue disease10.0HLA-DRB1, IL2, ALB
38hypersensitivity reaction type ii disease10.0ALB, IL2, HLA-DRB1
39lymphoma, non-hodgkin10.0IL2RB, IL2, HLA-DRB1
40systemic scleroderma10.0IL2RB, HLA-DRB1
41pulmonary fibrosis, idiopathic10.0IL2RB, IFNG
42hepatitis9.9HLA-DRB1, IL2RB, ALB
43primary biliary cirrhosis9.9HLA-DRB1, IL2RB, ALB
44thrombocytopenia9.9ALB, IL2
45tropical spastic paraparesis9.9IFNG, IL2, IL2RB
46acute graft versus host disease9.9IFNG, IL2RB, IL2
47sezary's disease9.9IL2RB, IL2, IFNG
48pulmonary sarcoidosis9.9IFNG, IL2, IL2RB
49lymphopenia9.9IFNG, IL2RB, IL2
50cutaneous t cell lymphoma9.9IFNG, IL2RB, IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Drug clinical trials:

Search ClinicalTrials for Berylliosis

Search NIH Clinical Center for Berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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MalaCards organs/tissues related to Berylliosis:

31
Lung, Testes, T cells, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

14
Lungs

Animal Models for Berylliosis or affiliated genes

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MGI Mouse Phenotypes related to Berylliosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ALB, IL2RB, IL2, IFNG
2MP:00053707.9ALB, IL2RB, IL2, IFNG

Publications for Berylliosis

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Articles related to Berylliosis:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. (10954202)
2000
7
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
8
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
9
Chronic berylliosis of the lung: report of a case. (16892748)
1996
10
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
11
Berylliosis. (2138073)
1990
12
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
13
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
14
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
15
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
16
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
17
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
18
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
19
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
20
Research into what happens in berylliosis. (1048889)
1976
21
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
22
Immunologic aspects of chronic berylliosis. (4540228)
1973
23
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
24
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
25
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
26
Immunoglobulin levels in berylliosis. (4129664)
1970
27
Pulmonary berylliosis: a case report. (6083249)
1967
28
Chronic berylliosis and calcospherite deposition. (5901642)
1966
29
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
30
Chronic berylliosis. (14498247)
1962
31
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
32
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
33
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
34
Beryllium and berylliosis. (13580272)
1958
35
Berylliosis. (14371570)
1955
36
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
37
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
38
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
39
Berylliosis; a new disease. (14933466)
1952
40
Chronic berylliosis in the neon sign industry. (14837525)
1951
41
Berylliosis and silicosis. (14841360)
1951
42
Some aspects of berylliosis. (14819024)
1951
43
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Berylliosis. (14771889)
1950
46
Non-occupational berylliosis. (18141686)
1949
47
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
48
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
49
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948
50
Berylliosis. (18102274)
1948

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.6IL2RB, IL2
2
Show member pathways
IL2 signaling events mediated by STAT536
9.6IL2RB, IL2
3
Show member pathways
9.6IL2RB, IL2
49.4IL2, IFNG
59.4IL2, IFNG
69.4IL2, IFNG
79.4IL2, IFNG
89.4IFNG, IL2
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4IFNG, IL2
109.4IFNG, IL2
11
Show member pathways
IL27-mediated signaling events36
9.4IFNG, IL2
12
Show member pathways
9.4HLA-DRB1, HLA-DPA1
139.4HLA-DRB1, HLA-DPA1
14
Show member pathways
9.4HLA-DRB1, HLA-DPA1
159.4HLA-DRB1, HLA-DPA1
16
Show member pathways
9.4HLA-DRB1, HLA-DPA1
17
Show member pathways
thioredoxin pathway36
9.0ALB, IFNG
18
Show member pathways
9.0HLA-DPA1, HLA-DRB1, IL2
19
Show member pathways
9.0IL2RB, IL2, IFNG
20
Show member pathways
Type III interferon signaling36
9.0IL2RB, IL2, IFNG
219.0IL2RB, IL2, IFNG
22
Show member pathways
9.0IFNG, IL2, IL2RB
23
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0IFNG, IL2, IL2RB
24
Show member pathways
IL-2 Signaling pathway36
9.0IL2RB, IL2, IFNG
25
Show member pathways
9.0IL2RB, IL2, IFNG
268.9IL2, IFNG, HLA-DRB1
278.9HLA-DRB1, IFNG, IL2
288.8IFNG, HLA-DRB1, HLA-DPA1
298.8HLA-DPA1, HLA-DRB1, IFNG
308.8HLA-DPA1, HLA-DRB1, IFNG
31
Show member pathways
8.8HLA-DPA1, HLA-DRB1, IFNG
32
Show member pathways
8.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
338.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
34
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
8.6HLA-DPA1, HLA-DRB1, IL2, IL2RB
35
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.5IL2RB, IL2, IFNG, HLA-DRB1
36
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
37
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
38
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
39
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
40
Show member pathways
7.9IL2RB, IL2, IFNG, HLA-DRB1, HLA-DPA1

Compounds for genes affiliated with Berylliosis

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Compounds related to Berylliosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1r-il-24310.0IL2RB, IL2
2denileukin diftitox43 49 1212.0IL2RB, IL2
3ctla4-ig4310.0IL2, IL2RB
4daclizumab43 1211.0IL2RB, IL2
5basiliximab43 1210.9IL2RB, IL2
6alemtuzumab43 1210.9IL2RB, IL2
7levamisole43 1210.9IL2, IL2RB
8chromium439.9IL2RB, IL2
9interferon gamma439.8IL2, IFNG
10dpa 1439.8HLA-DPA1, HLA-DRB1
11bucillamine439.8IFNG, IL2
12alpha-galactosylceramide439.8IL2, IFNG
13taurine chloramine439.8IL2, IFNG
14pirfenidone43 5910.7IL2, IFNG
15fumarate43 1210.7IFNG, IL2
16il-12439.7IL2, IFNG
17piroxicam43 1210.6ALB, IL2
18zoledronic acid439.5IL2, IFNG
19sulfamethoxazole49 43 1211.4ALB, IL2
20gm-csf43 2810.4IFNG, IL2
21polyinosinic-polycytidylic acid439.4IL2, IFNG
22okt3439.4IL2RB, IL2, IFNG
23con a439.4IL2RB, IL2, IFNG
242,5-oligoadenylate439.4IFNG, IL2, IL2RB
25gamma globulin439.4ALB, IFNG
26il 10439.4IFNG, IL2, IL2RB
27pentoxifylline43 1210.4IFNG, IL2, IL2RB
28ifn-alpha439.4IL2RB, IL2, IFNG
29neopterin439.4IL2RB, IL2, IFNG
30gold sodium thiomalate439.4HLA-DRB1, IFNG, IL2
31glatiramer acetate43 1210.4HLA-DRB1, IFNG, IL2
32ionomycin439.4IFNG, IL2, IL2RB
33polysulfone439.3IL2RB, ALB
34triptolide439.3IFNG, IL2
35rantes439.3IFNG, IL2, IL2RB
36aminoguanidine43 28 1211.3ALB, IFNG
37mycophenolic acid43 49 1211.2IL2, IL2RB, ALB
38naloxone43 28 49 1212.2ALB, IL2RB, IL2
39l-tryptophan49 28 43 24 1213.2ALB, IFNG
40rapamycin439.1IL2RB, IL2, IFNG
41methotrexate49 43 1211.0HLA-DRB1, IL2RB, ALB
42ivig439.0ALB, IL2RB, IFNG
43calcitriol43 59 24 1212.0ALB, IL2, IFNG
44indomethacin43 28 59 1211.9IFNG, IL2, ALB
45genistein43 28 59 2 24 1213.7IL2RB, IL2, IFNG
46auranofin28 43 59 1211.6ALB, IL2RB, IL2, IFNG
47mycophenolate mofetil43 49 1210.6IFNG, IL2, IL2RB, ALB
48prednisolone43 28 1210.6ALB, IL2RB, IL2, IFNG
49tacrolimus43 49 1210.6ALB, IL2RB, IL2, IFNG
50histamine43 28 2410.6ALB, IL2RB, IL2, IFNG

GO Terms for genes affiliated with Berylliosis

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Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.6HLA-DRB1, HLA-DPA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.5HLA-DRB1, HLA-DPA1
3clathrin-coated endocytic vesicle membraneGO:00306699.5HLA-DPA1, HLA-DRB1
4transport vesicle membraneGO:00306589.4HLA-DRB1, HLA-DPA1
5endocytic vesicle membraneGO:00306669.4HLA-DRB1, HLA-DPA1
6ER to Golgi transport vesicle membraneGO:00125079.3HLA-DRB1, HLA-DPA1
7trans-Golgi network membraneGO:00325889.1HLA-DRB1, HLA-DPA1
8external side of plasma membraneGO:00098979.1IL2RB, IFNG, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:00483049.6IL2, IFNG
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.4HLA-DRB1, HLA-DPA1
3T cell costimulationGO:00312959.3HLA-DPA1, HLA-DRB1
4T cell receptor signaling pathwayGO:00508529.1HLA-DRB1, HLA-DPA1
5immune responseGO:00069559.1HLA-DPA1, HLA-DRB1, IL2
6interferon-gamma-mediated signaling pathwayGO:00603339.0HLA-DPA1, HLA-DRB1, IFNG
7negative regulation of apoptotic processGO:00430668.8ALB, IL2RB, IL2
8cytokine-mediated signaling pathwayGO:00192218.5IL2RB, IFNG, HLA-DRB1, HLA-DPA1

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.4HLA-DRB1, HLA-DPA1

Products for genes affiliated with Berylliosis

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Sources for Berylliosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet