MCID: BRY001
MIFTS: 38

Berylliosis

Categories: Respiratory diseases

Aliases & Classifications for Berylliosis

MalaCards integrated aliases for Berylliosis:

Name: Berylliosis 12 42 14
Beryllium Poisoning 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10322
ICD10 33 J63.2
MeSH 42 D001607
SNOMED-CT 64 8247009
UMLS 69 C0005138

Summaries for Berylliosis

Disease Ontology : 12 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary : Berylliosis, also known as beryllium poisoning, is related to chronic beryllium disease and beryllium disease. An important gene associated with Berylliosis is HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Infliximab and Mesalamine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes.

Wikipedia : 72 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
id Related Disease Score Top Affiliating Genes
1 chronic beryllium disease 11.8
2 beryllium disease 11.6
3 posterior column ataxia 10.4 HLA-DPA1 HLA-DPB1
4 bulbospinal polio 10.2 IFNG IL2
5 autoimmune polyglandular syndrome type 3 10.2 IFNG IL2
6 graft-versus-host disease, protection against 10.2 IFNG IL2
7 x-linked intellectual disability, van esch type 10.2 IFNG IL2
8 plantar wart 10.2 IFNG IL2
9 amyotrophic lateral sclerosis type 10 10.2 IFNG IL2
10 parametritis 10.2 IFNG IL2
11 chronic graft versus host disease 10.2 IFNG IL2
12 cyclosporiasis 10.2 IFNG IL2
13 tularemia 10.2 IFNG IL2
14 gonadal disease 10.2 IFNG IL2
15 bolivian hemorrhagic fever 10.2 IFNG IL2
16 hemophagocytic lymphohistiocytosis 10.2 IFNG IL2
17 acute monoblastic leukemia 10.2 IFNG IL2
18 cd3zeta deficiency 10.2 IFNG IL2
19 acute necrotizing encephalopathy type 1 10.2 IFNG IL2
20 hypospadias 10.2 IFNG IL2
21 membranoproliferative glomerulonephritis 10.2 IFNG IL2
22 louping ill 10.2 IFNG IL2
23 orbital osteomyelitis 10.2 IFNG IL2
24 sezary's disease 10.2 IFNG IL2
25 abnormal retinal correspondence 10.2 IFNG IL2
26 central nervous system origin vertigo 10.2 IFNG IL2
27 esophagus melanoma 10.1 IFNG IL2
28 legionellosis 10.1 IFNG IL2
29 myelitis 10.1 IFNG IL2
30 heart sarcoma 10.1 IFNG IL2
31 erythema infectiosum 10.1 IFNG IL2
32 corneal intraepithelial neoplasm 10.1 IFNG IL2
33 gastric ulcer 10.1 IFNG IL2
34 acute interstitial pneumonia 10.1 IFNG IL2
35 fuchs' heterochromic uveitis 10.1 IFNG IL2
36 intestinal disaccharidase deficiency 10.1 IFNG IL2
37 renal tubular acidosis 10.1 IFNG IL2
38 cloacogenic carcinoma 10.1 IFNG IL2
39 opportunistic bacterial infectious disease 10.1 IFNG IL2
40 mucocutaneous leishmaniasis 10.1 IFNG IL2
41 blue toe syndrome 10.1 IFNG IL2
42 malignant hyperthermia 10.1 IFNG IL2
43 ovarian surface papilloma 10.1 HLA-DPA1 HLA-DRB1
44 lymphoma 10.1 IFNG IL2
45 uterus interstitial leiomyoma 10.1 IFNG IL2
46 childhood testicular mixed germ cell tumor 10.1 IFNG IL2
47 hyperpigmentation of eyelid 10.0 IFNG IL2
48 acral lentiginous melanoma 10.0 IFNG IL2
49 biemond syndrome 10.0 HLA-DPB1 HLA-DRB1
50 hypereosinophilic syndrome 10.0 HLA-DRB1 IFNG

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to Berylliosis

Symptoms & Phenotypes for Berylliosis

Drugs & Therapeutics for Berylliosis

Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 1, Phase 2 170277-31-3
2 Mesalamine Phase 1, Phase 2 89-57-6
3 Analgesics Phase 1, Phase 2
4 Analgesics, Non-Narcotic Phase 1, Phase 2
5 Peripheral Nervous System Agents Phase 1, Phase 2
6 Anti-Inflammatory Agents Phase 1, Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
8 Antirheumatic Agents Phase 1, Phase 2
9 Gastrointestinal Agents Phase 1, Phase 2
10 Dermatologic Agents Phase 1, Phase 2
11
Heparin Approved, Investigational 9005-49-6 772 46507594
12 calcium heparin
13 Pharmaceutical Solutions

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
2 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
3 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
4 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
5 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693

Search NIH Clinical Center for Berylliosis

Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

Anatomical Context for Berylliosis

MalaCards organs/tissues related to Berylliosis:

39
Lung, T Cells, Testes, Bone, Monocytes

Publications for Berylliosis

Articles related to Berylliosis:

(show top 50) (show all 73)
id Title Authors Year
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. ( 19191908 )
2009
2
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. ( 16315779 )
2005
3
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. ( 15778396 )
2005
4
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. ( 16098233 )
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. ( 11423174 )
2001
6
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. ( 11405518 )
2001
7
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. ( 10954202 )
2000
8
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. ( 9877510 )
1998
9
Interaction of genetic and exposure factors in the prevalence of berylliosis. ( 9258386 )
1997
10
Beryllium induces IL-2 and IFN-gamma in berylliosis. ( 8977230 )
1997
11
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. ( 9230733 )
1997
12
Chronic berylliosis of the lung: report of a case. ( 16892748 )
1996
13
The computed tomographic appearances in chronic berylliosis. ( 8428413 )
1993
14
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. ( 1599873 )
1992
15
Berylliosis. ( 2138073 )
1990
16
A study of immunological indices for diagnosis of chronic berylliosis. ( 2604898 )
1989
17
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. ( 3168359 )
1988
18
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. ( 3328191 )
1987
19
Inhalant granulomas: silicosis, asbestosis, berylliosis. ( 7133715 )
1982
20
Pulmonary berylliosis: report on a fatal case. ( 7126443 )
1982
21
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. ( 7103279 )
1982
22
Berylliosis. ( 7381961 )
1980
23
Non-bony uptake of technetium-99m MDP in berylliosis. ( 7437734 )
1980
24
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. ( 436529 )
1979
25
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. ( 159411 )
1979
26
Experimental aerogenic pulmonary berylliosis in rabbits. ( 147415 )
1978
27
Concentration of immunoglobulins in berylliosis. ( 564365 )
1977
28
Berylliosis as an auto-immune disorder. ( 942183 )
1976
29
Research into what happens in berylliosis. ( 1048889 )
1976
30
Case report. Pulmonary berylliosis following exposure to beryllium-copper. ( 1063889 )
1976
31
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. ( 4533844 )
1974
32
Chronic berylliosis. ( 4526035 )
1974
33
Chronic berylliosis. ( 4274186 )
1973
34
Immunologic aspects of chronic berylliosis. ( 4540228 )
1973
35
A study of the immunologic aspects of chronic berylliosis. ( 4690875 )
1973
36
Immunity to pulmonary berylliosis in guinea pigs. ( 5036157 )
1972
37
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. ( 5061834 )
1972
38
Immunoglobulin levels in berylliosis. ( 4129664 )
1970
39
The role of immunologic reactions in pulmonary berylliosis. ( 5527729 )
1970
40
Immunoglobulin concentrationsn berylliosis. ( 4191591 )
1970
41
Serological reactions of berylliosis patients to extracts of lung tissue. ( 5644743 )
1968
42
Pulmonary berylliosis: a case report. ( 6083249 )
1967
43
Chronic berylliosis and calcospherite deposition. ( 5901642 )
1966
44
PROBABLE BERYLLIOSIS FROM BERYLLIUM ALLOYS. ( 14185553 )
1964
45
Berylliosis: report of two cases, with special reference to the patch test. ( 13938965 )
1963
46
The mineral content of the lung in chronic berylliosis. ( 13991590 )
1962
47
Chronic berylliosis. ( 14498247 )
1962
48
Chronic pulmonary berylliosis in a female chemist. ( 13773748 )
1961
49
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. ( 13761591 )
1961
50
Berylliosis, bones, and behavior: an illustrative case report. ( 13738917 )
1960

Variations for Berylliosis

Expression for Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for Berylliosis

Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
2
Show member pathways
13.06 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
3
Show member pathways
12.93 HLA-DPA1 HLA-DRB1 IFNG IL2
4
Show member pathways
12.46 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
5
Show member pathways
12.35 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
6
Show member pathways
12.33 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
7 12.22 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
8
Show member pathways
12.18 HLA-DPA1 HLA-DRB1 IL2
9
Show member pathways
12.14 HLA-DPA1 HLA-DPB1 HLA-DRB1
10
Show member pathways
12.11 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
11 12.09 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
12
Show member pathways
12.03 HLA-DPA1 HLA-DPB1 HLA-DRB1
13
Show member pathways
12.01 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
14 11.96 HLA-DPA1 HLA-DPB1 HLA-DRB1
15 11.93 HLA-DPA1 HLA-DPB1 HLA-DRB1
16 11.92 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
17
Show member pathways
11.81 HLA-DRB1 IFNG IL2
18
Show member pathways
11.79 HLA-DPA1 HLA-DPB1 HLA-DRB1
19 11.76 HLA-DPA1 HLA-DPB1 HLA-DRB1
20 11.75 HLA-DPA1 HLA-DPB1 HLA-DRB1
21
Show member pathways
11.72 IFNG IL2
22 11.72 HLA-DPA1 HLA-DPB1 HLA-DRB1
23
Show member pathways
11.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
24 11.6 IFNG IL2
25 11.58 IFNG IL2
26
Show member pathways
11.56 IFNG IL2
27
Show member pathways
11.56 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
28 11.55 IFNG IL2
29 11.52 HLA-DPA1 HLA-DRB1
30 11.49 IFNG IL2
31
Show member pathways
11.46 IFNG IL2
32 11.45 HLA-DPA1 HLA-DPB1 HLA-DRB1
33
Show member pathways
11.44 IFNG IL2
34 11.36 IFNG IL2
35 11.33 IFNG IL2
36 11.32 IFNG IL2
37
Show member pathways
11.24 IFNG IL2
38 11.21 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
39 11.15 IFNG IL2
40 11.11 HLA-DRB1 IFNG IL2
41 11.04 IFNG IL2
42 11.03 HLA-DRB1 IFNG IL2

GO Terms for Berylliosis

Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.7 HLA-DPA1 HLA-DPB1 HLA-DRB1
2 endosome GO:0005768 9.69 HLA-DPA1 HLA-DPB1 HLA-DRB1
3 cell surface GO:0009986 9.67 HLA-DPA1 HLA-DPB1 HLA-DRB1
4 lysosome GO:0005764 9.65 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 lysosomal membrane GO:0005765 9.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
6 endosome membrane GO:0010008 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
7 trans-Golgi network membrane GO:0032588 9.58 HLA-DPA1 HLA-DPB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.54 HLA-DPA1 HLA-DPB1 HLA-DRB1
9 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DPA1 HLA-DPB1 HLA-DRB1
10 transport vesicle membrane GO:0030658 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DPA1 HLA-DPB1 HLA-DRB1
13 MHC class II protein complex GO:0042613 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 HLA-DPA1 HLA-DPB1 HLA-DRB1 IL2
2 immune response GO:0006955 9.72 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG IL2
3 T cell receptor signaling pathway GO:0050852 9.67 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.63 HLA-DPA1 HLA-DPB1 HLA-DRB1
5 T cell costimulation GO:0031295 9.61 HLA-DPA1 HLA-DPB1 HLA-DRB1
6 positive regulation of interferon-gamma production GO:0032729 9.58 HLA-DPA1 HLA-DPB1 IL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNG IL2
8 positive regulation of T cell activation GO:0050870 9.51 HLA-DPA1 HLA-DPB1
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.49 IFNG IL2
10 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DPA1 HLA-DPB1 HLA-DRB1
12 positive regulation of T cell proliferation GO:0042102 9.26 HLA-DPA1 HLA-DPB1 IFNG IL2
13 antigen processing and presentation GO:0019882 8.92 HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DPA1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-DPA1 HLA-DPB1 HLA-DRB1

Sources for Berylliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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