MCID: BRY001
MIFTS: 51

Berylliosis malady

Rare diseases, Respiratory diseases categories

Summaries for Berylliosis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards: Berylliosis, also known as subacute berylliosis, is related to chronic berylliosis and silicosis. An important gene associated with Berylliosis is IL2 (interleukin 2), and among its related pathways are Immune response IL 2 activation and signaling pathway and IL2 signaling events mediated by PI3K. The compounds r-il-2 and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and testes, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:66 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Aliases & Classifications for Berylliosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

berylliosis 9 44
subacute berylliosis 44 63
acute berylliosis 44 63
chronic pulmonary berylliosis 44
reversible berylliosis 44
beryllium poisoning 9


External Ids:

Disease Ontology9 DOID:10322
MeSH36 D001607
SNOMED-CT59 8247009
ICD1026 J63.2

Related Diseases for Berylliosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Berylliosis family:

Chronic Berylliosis

Diseases related to Berylliosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1chronic berylliosis10.7
2silicosis10.3
3asbestosis10.2
4capillary leak syndrome10.1IL2
5ulcerative colitis10.1ALB
6thyroiditis10.1HLA-DRB1
7t-cell large granular lymphocyte leukemia10.1IL2RB, IL2
8immunodeficiency, common variable, 710.1IL2, IL2RB
9gamma chain deficiency10.1IL2RB, IL2
10common variable immune deficiency10.1IL2, IL2RB
11leprosy10.1IL2, HLA-DRB1
12hairy cell leukemia10.1IL2RB, IL2
13uveitis10.0IFNG
14acquired immunodeficiency syndrome10.0IL2, ALB
15mycosis fungoides10.0IL2, IL2RB
16lipoid nephrosis10.0ALB, IL2RB
17leukopenia10.0IL2, ALB
18cork-handlers' disease10.0IL2, ALB
19kidney rhabdoid cancer10.0IL2, IL2RB
20diphtheria10.0IL2RB, IL2
21polymyalgia rheumatica10.0IL2RB, HLA-DRB1
22diarrhea10.0ALB, IL2
23juvenile rheumatoid arthritis10.0HLA-DRB1, IL2RB
24lepromatous leprosy10.0IFNG, IL2
25b-cell chronic lymphocytic leukemia10.0IL2RB, IL2
26rheumatic fever10.0
27hypertension10.0
28pneumoconiosis10.0
29klebsiella10.0
30toxic shock syndrome10.0IFNG, IL2
31factor vii deficiency10.0IL2, IFNG
32myasthenia gravis10.0IL2, IFNG
33precursor t-cell acute lymphoblastic leukemia10.0IL2RB, IL2
34type 1 diabetes mellitus10.0IFNG, HLA-DRB1
35plasmodium falciparum malaria10.0IFNG, HLA-DRB1
36encephalomyelitis10.0IL2, IFNG
37skin disease10.0HLA-DRB1, IL2, ALB
38connective tissue disease10.0ALB, IL2, HLA-DRB1
39hypersensitivity reaction type ii disease10.0ALB, IL2, HLA-DRB1
40non-hodgkin lymphoma10.0IL2RB, IL2, HLA-DRB1
41idiopathic pulmonary fibrosis10.0IL2RB, IFNG
42systemic scleroderma10.0IL2RB, HLA-DRB1
43hepatitis10.0HLA-DRB1, IL2RB, ALB
44primary biliary cirrhosis10.0ALB, IL2RB, HLA-DRB1
45thrombocytopenia10.0IL2, ALB
46tropical spastic paraparesis10.0IL2RB, IL2, IFNG
47acute graft versus host disease10.0IFNG, IL2, IL2RB
48sezary's disease10.0IFNG, IL2, IL2RB
49pulmonary sarcoidosis10.0IL2RB, IL2, IFNG
50lymphopenia10.0IL2RB, IL2, IFNG

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Berylliosis

Drug clinical trials:

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Search NIH Clinical Center for Berylliosis

Search CenterWatch for Berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Berylliosis:

34
Lung, Testes, T cells, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

15
Lungs

Animal Models for Berylliosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Berylliosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ALB, IL2RB, IL2, IFNG
2MP:00053707.9ALB, IL2RB, IL2, IFNG

Publications for Berylliosis

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Sources:
53PubMed
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Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
6
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
7
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
8
Chronic berylliosis of the lung: report of a case. (16892748)
1996
9
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
10
Berylliosis. (2138073)
1990
11
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
12
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
13
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
14
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
15
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
16
Berylliosis. (7381961)
1980
17
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
18
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
19
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
20
Research into what happens in berylliosis. (1048889)
1976
21
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
22
Chronic berylliosis. (4274186)
1973
23
Immunologic aspects of chronic berylliosis. (4540228)
1973
24
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
25
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
26
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
27
Immunoglobulin levels in berylliosis. (4129664)
1970
28
Pulmonary berylliosis: a case report. (6083249)
1967
29
Chronic berylliosis and calcospherite deposition. (5901642)
1966
30
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
31
Chronic berylliosis. (14498247)
1962
32
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
33
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960
34
Berylliosis, bones, and behavior: an illustrative case report. (13738917)
1960
35
Beryllium and berylliosis. (13580272)
1958
36
Berylliosis. (14371570)
1955
37
An unusual case of joint pains and fever; berylliosis and pulmonary hypertension mistaken for rheumatic fever. (13172869)
1954
38
Berylliosis; summary and survey of all clinical types observed in a twelve-year period. (13057385)
1953
39
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (14940683)
1952
40
Chronic berylliosis in the neon sign industry. (14837525)
1951
41
Berylliosis and silicosis. (14841360)
1951
42
Some aspects of berylliosis. (14819024)
1951
43
Chronic pulmonary berylliosis in workers using fluorescent powders containing beryllium. (15426337)
1950
44
Berylliosis; brief discussion and presentation of a case with pulmonary, digital and axillary node involvement. (14780026)
1950
45
Berylliosis. (14771889)
1950
46
Non-occupational berylliosis. (18141686)
1949
47
The value of beryllium determinations in the diagnosis of berylliosis. (18114454)
1949
48
Berylliosis; acute pneumonitis and pulmonary granulomatosis of beryllium workers. (18113769)
1948
49
Berylliosis; observations and report of clinical study of 70 cases of chronic disease. (18208267)
1948
50
Berylliosis. (18102274)
1948

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Berylliosis

Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 55R&D Systems, 31KEGG
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Pathways related to Berylliosis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 3 activation and signaling pathway61
9.6IL2RB, IL2
2
Show member pathways
IL2 signaling events mediated by STAT539
9.6IL2RB, IL2
3
Show member pathways
9.6IL2RB, IL2
49.4IL2, IFNG
59.4IL2, IFNG
69.4IL2, IFNG
79.4IL2, IFNG
89.4IFNG, IL2
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.4IFNG, IL2
109.4IFNG, IL2
11
Show member pathways
IL27-mediated signaling events39
9.4IFNG, IL2
12
Show member pathways
9.4HLA-DRB1, HLA-DPA1
139.4HLA-DRB1, HLA-DPA1
14
Show member pathways
9.4HLA-DRB1, HLA-DPA1
159.4HLA-DRB1, HLA-DPA1
16
Show member pathways
9.4HLA-DRB1, HLA-DPA1
17
Show member pathways
thioredoxin pathway39
9.0ALB, IFNG
18
Show member pathways
9.0HLA-DPA1, HLA-DRB1, IL2
19
Show member pathways
9.0IL2RB, IL2, IFNG
20
Show member pathways
Type III interferon signaling39
9.0IL2RB, IL2, IFNG
219.0IL2RB, IL2, IFNG
22
Show member pathways
9.0IFNG, IL2, IL2RB
23
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0IFNG, IL2, IL2RB
24
Show member pathways
IL-2 Signaling pathway39
9.0IL2RB, IL2, IFNG
25
Show member pathways
9.0IL2RB, IL2, IFNG
268.9IL2, IFNG, HLA-DRB1
278.9HLA-DRB1, IFNG, IL2
288.8IFNG, HLA-DRB1, HLA-DPA1
298.8HLA-DPA1, HLA-DRB1, IFNG
308.8HLA-DPA1, HLA-DRB1, IFNG
31
Show member pathways
8.8HLA-DPA1, HLA-DRB1, IFNG
32
Show member pathways
8.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
338.6IL2RB, IL2, HLA-DRB1, HLA-DPA1
34
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
8.6HLA-DPA1, HLA-DRB1, IL2, IL2RB
35
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.5IL2RB, IL2, IFNG, HLA-DRB1
36
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
37
Show member pathways
8.4HLA-DPA1, HLA-DRB1, IFNG, IL2
38
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
39
Show member pathways
7.9HLA-DPA1, HLA-DRB1, IFNG, IL2, IL2RB
40
Show member pathways
7.9IL2RB, IL2, IFNG, HLA-DRB1, HLA-DPA1

Compounds for genes affiliated with Berylliosis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Berylliosis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1r-il-24610.0IL2RB, IL2
2denileukin diftitox46 52 1212.0IL2RB, IL2
3ctla4-ig4610.0IL2, IL2RB
4daclizumab46 1211.0IL2RB, IL2
5basiliximab46 1210.9IL2RB, IL2
6alemtuzumab46 1210.9IL2RB, IL2
7levamisole46 1210.9IL2, IL2RB
8chromium469.9IL2RB, IL2
9interferon gamma469.8IL2, IFNG
10dpa 1469.8HLA-DPA1, HLA-DRB1
11bucillamine469.8IFNG, IL2
12alpha-galactosylceramide469.8IL2, IFNG
13taurine chloramine469.8IL2, IFNG
14pirfenidone46 6210.7IL2, IFNG
15fumarate46 1210.7IFNG, IL2
16il-12469.7IL2, IFNG
17piroxicam46 1210.6ALB, IL2
18zoledronic acid469.5IL2, IFNG
19sulfamethoxazole52 46 1211.4ALB, IL2
20gm-csf46 3010.4IFNG, IL2
21polyinosinic-polycytidylic acid469.4IL2, IFNG
22okt3469.4IL2RB, IL2, IFNG
23con a469.4IL2RB, IL2, IFNG
242,5-oligoadenylate469.4IFNG, IL2, IL2RB
25gamma globulin469.4ALB, IFNG
26il 10469.4IFNG, IL2, IL2RB
27pentoxifylline46 1210.4IFNG, IL2, IL2RB
28ifn-alpha469.4IL2RB, IL2, IFNG
29neopterin469.4IL2RB, IL2, IFNG
30gold sodium thiomalate469.4HLA-DRB1, IFNG, IL2
31glatiramer acetate46 1210.4HLA-DRB1, IFNG, IL2
32ionomycin469.4IFNG, IL2, IL2RB
33polysulfone469.3IL2RB, ALB
34triptolide469.3IFNG, IL2
35rantes469.3IFNG, IL2, IL2RB
36aminoguanidine46 30 1211.3ALB, IFNG
37mycophenolic acid46 52 1211.2IL2, IL2RB, ALB
38naloxone46 30 52 1212.2ALB, IL2RB, IL2
39l-tryptophan52 30 46 25 1213.2ALB, IFNG
40rapamycin469.1IL2RB, IL2, IFNG
41methotrexate52 46 1211.0HLA-DRB1, IL2RB, ALB
42ivig469.0ALB, IL2RB, IFNG
43calcitriol46 62 25 1212.0ALB, IL2, IFNG
44indomethacin46 30 62 1211.9IFNG, IL2, ALB
45genistein46 30 62 3 25 1213.7IL2RB, IL2, IFNG
46auranofin30 46 62 1211.6ALB, IL2RB, IL2, IFNG
47mycophenolate mofetil46 52 1210.6IFNG, IL2, IL2RB, ALB
48prednisolone46 30 1210.6ALB, IL2RB, IL2, IFNG
49tacrolimus46 52 1210.6ALB, IL2RB, IL2, IFNG
50histamine46 30 2510.6ALB, IL2RB, IL2, IFNG

GO Terms for genes affiliated with Berylliosis

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Sources:
17Gene Ontology
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Cellular components related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.6HLA-DRB1, HLA-DPA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.5HLA-DRB1, HLA-DPA1
3clathrin-coated endocytic vesicle membraneGO:0306699.5HLA-DPA1, HLA-DRB1
4transport vesicle membraneGO:0306589.4HLA-DRB1, HLA-DPA1
5endocytic vesicle membraneGO:0306669.4HLA-DRB1, HLA-DPA1
6ER to Golgi transport vesicle membraneGO:0125079.3HLA-DRB1, HLA-DPA1
7trans-Golgi network membraneGO:0325889.1HLA-DRB1, HLA-DPA1
8external side of plasma membraneGO:0098979.1IL2RB, IFNG, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IFNG
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.4HLA-DRB1, HLA-DPA1
3T cell costimulationGO:0312959.3HLA-DPA1, HLA-DRB1
4T cell receptor signaling pathwayGO:0508529.1HLA-DRB1, HLA-DPA1
5immune responseGO:0069559.1HLA-DPA1, HLA-DRB1, IL2
6interferon-gamma-mediated signaling pathwayGO:0603339.0HLA-DPA1, HLA-DRB1, IFNG
7negative regulation of apoptotic processGO:0430668.8ALB, IL2RB, IL2
8cytokine-mediated signaling pathwayGO:0192218.5IL2RB, IFNG, HLA-DRB1, HLA-DPA1

Molecular functions related to Berylliosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.4HLA-DRB1, HLA-DPA1

Products for genes affiliated with Berylliosis

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  • Antibodies
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Sources for Berylliosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet