MCID: BRY001
MIFTS: 38

Berylliosis malady

Category: Respiratory diseases

Aliases & Classifications for Berylliosis

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Aliases & Descriptions for Berylliosis:

Name: Berylliosis 11 39 13
 
Beryllium Poisoning 11

Classifications:



External Ids:

Disease Ontology11 DOID:10322
ICD1030 J63.2
SNOMED-CT62 8247009
MeSH39 D001607

Summaries for Berylliosis

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Disease Ontology:11 A pneumoconiosis that involves allergic response located in lungs caused by inhalation of beryllium compounds.

MalaCards based summary: Berylliosis, also known as beryllium poisoning, is related to chronic beryllium disease and beryllium disease. An important gene associated with Berylliosis is IFNG (Interferon Gamma), and among its related pathways are Downstream signaling in naive CD8+ T cells and Th2 Differentiation Pathway. Affiliated tissues include lungs, lung and t cells.

Wikipedia:71 Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic... more...

Related Diseases for Berylliosis

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Diseases related to Berylliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1chronic beryllium disease11.8
2beryllium disease11.7
3bulbospinal polio10.4IFNG, IL2
4graft-versus-host disease, protection against10.4IFNG, IL2
5thomsen and becker disease10.4IFNG, IL2
6addison's disease10.4IFNG, IL2
7calcifying epithelial odontogenic tumor10.4IFNG, IL2
8potter's syndrome10.4IFNG, IL2
9pneumonic tularemia10.4IFNG, IL2
10bolivian hemorrhagic fever10.4IFNG, IL2
11collagen disease10.4IFNG, IL2
12hypospadias10.4IFNG, IL2
13lacrimal system cancer10.4IFNG, IL2
14cd3zeta deficiency10.3IFNG, IL2
15louping ill10.3IFNG, IL2
16x-linked intellectual disability, siderius type10.3IFNG, IL2
17subendocardial infarction acute myocardial infarction10.3IFNG, IL2
18common cold10.3IFNG, IL2
19esophagus melanoma10.3IFNG, IL2
20lymphocytic colitis10.3HLA-DRB1, IFNG
21chronic polyneuropathy10.3HLA-DRB1, IFNG
22hernia of ovary and fallopian tube10.3HLA-DRB1, IFNG
23bacteriuria10.3IFNG, IL2
24orbit alveolar rhabdomyosarcoma10.3HLA-DRB1, IFNG
25jejunal somatostatinoma10.3IFNG, IL2
26aseptic osteitis10.3HLA-DRB1, IFNG
27heart leiomyosarcoma10.3IFNG, IL2
28dengue disease10.3IFNG, IL2
29sensorineural hearing loss10.3HLA-DRB1, IFNG
30mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3HLA-DRB1, IFNG
31hemophagocytic lymphohistiocytosis10.3HLA-DRB1, IFNG
32gastric ulcer10.3IFNG, IL2
33toxic maculopathy10.3IFNG, IL2
34fibrous histiocytoma10.3HLA-DRB1, IFNG
35smooth muscle tumor10.3HLA-DRB1, IFNG
36exophthalmos10.3IFNG, IL2
37vitreoretinochoroidopathy dominant10.3HLA-DRB1, IL2
38conventional malignant hemangiopericytoma10.3IFNG, IL2
39bile duct signet ring cell carcinoma10.3HLA-DRB1, IFNG
40seborrheic dermatitis10.3IFNG, IL2
41lung occult large cell carcinoma10.3IFNG, IL2
42skin sarcoidosis10.3HLA-DRB1, IL2
43reproductive system disease10.3HLA-DRB1, IFNG
44renal tubular acidosis10.3IFNG, IL2
45variola minor10.3IFNG, IL2
46respiratory system disease10.3HLA-DRB1, IL2
47opportunistic bacterial infectious disease10.3IFNG, IL2
48idiopathic interstitial pneumonia10.3IFNG, IL2
49dermatitis herpetiformis, familial10.3HLA-DRB1, IFNG
50renovascular hypertension10.2HLA-DRB1, IL2

Graphical network of the top 20 diseases related to Berylliosis:



Diseases related to berylliosis

Symptoms & Phenotypes for Berylliosis

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Drugs & Therapeutics for Berylliosis

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Drugs for Berylliosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
InfliximabapprovedPhase 1, Phase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
2MesalaminePhase 1, Phase 216089-57-6
3AnalgesicsPhase 1, Phase 211287
4Antirheumatic AgentsPhase 1, Phase 210627
5Peripheral Nervous System AgentsPhase 1, Phase 222776
6Analgesics, Non-NarcoticPhase 1, Phase 26260
7Anti-Inflammatory AgentsPhase 1, Phase 210355
8Anti-Inflammatory Agents, Non-SteroidalPhase 1, Phase 24295
9Gastrointestinal AgentsPhase 1, Phase 28109
10Dermatologic AgentsPhase 1, Phase 25674
11
Heparinapproved, investigational8129005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
12Pharmaceutical Solutions7793
13calcium heparin812

Interventional clinical trials:

idNameStatusNCT IDPhase
1Targeting Oxidative Stress in Chronic Beryllium DiseaseCompletedNCT01088243Phase 1, Phase 2
2Beryllium Infliximab Study: Clinical Interventional TrialTerminatedNCT00111917Phase 1, Phase 2
3Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and SarcoidosisCompletedNCT00560989
4The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD)RecruitingNCT02596347
5Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)RecruitingNCT02604693

Search NIH Clinical Center for Berylliosis


Cochrane evidence based reviews: berylliosis

Genetic Tests for Berylliosis

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Anatomical Context for Berylliosis

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MalaCards organs/tissues related to Berylliosis:

36
Lung, T cells, Testes, Bone, Monocytes

FMA organs/tissues related to Berylliosis:

17
Lungs

Publications for Berylliosis

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Articles related to Berylliosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. (19191908)
2009
2
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. (15778396)
2005
3
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (16098233)
2005
4
Role of the berylliosis-associated HLA-DPGlu69 supratypic variant in determining the response to beryllium in a blood T-cells beryllium-stimulated proliferation test. (16315779)
2005
5
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis. (11405518)
2001
6
Beryllium binding to HLA-DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69. (11423174)
2001
7
Analysis of differentially regulated mRNAs in peripheral blood monocytes of berylliosis patients after in vitro stimulation. (10954202)
2000
8
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model. (9877510)
1998
9
Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. (9230733)
1997
10
Beryllium induces IL-2 and IFN-gamma in berylliosis. (8977230)
1997
11
Interaction of genetic and exposure factors in the prevalence of berylliosis. (9258386)
1997
12
Chronic berylliosis of the lung: report of a case. (16892748)
1996
13
The computed tomographic appearances in chronic berylliosis. (8428413)
1993
14
Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model. (1599873)
1992
15
Berylliosis. (2138073)
1990
16
A study of immunological indices for diagnosis of chronic berylliosis. (2604898)
1989
17
Chronic berylliosis. Demonstration by gallium-67 imaging and magnetic resonance imaging. (3168359)
1988
18
Pulmonary berylliosis on corticosteroid therapy, with cavitating lung lesions and aspergillomata--report on a fatal case. (3328191)
1987
19
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis. (7103279)
1982
20
Pulmonary berylliosis: report on a fatal case. (7126443)
1982
21
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
22
Berylliosis. (7381961)
1980
23
Non-bony uptake of technetium-99m MDP in berylliosis. (7437734)
1980
24
Mixed pneumoconiosis: silicosis, asbestosis, talcosis, and berylliosis. (436529)
1979
25
Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity. (159411)
1979
26
Experimental aerogenic pulmonary berylliosis in rabbits. (147415)
1978
27
Concentration of immunoglobulins in berylliosis. (564365)
1977
28
Case report. Pulmonary berylliosis following exposure to beryllium-copper. (1063889)
1976
29
Research into what happens in berylliosis. (1048889)
1976
30
Berylliosis as an auto-immune disorder. (942183)
1976
31
Chronic berylliosis. (4526035)
1974
32
The influence of cutaneous hypersensitivity to beryllium on the development of experimental pulmonary berylliosis. (4533844)
1974
33
Immunologic aspects of chronic berylliosis. (4540228)
1973
34
Chronic berylliosis. (4274186)
1973
35
A study of the immunologic aspects of chronic berylliosis. (4690875)
1973
36
Immunity to pulmonary berylliosis in guinea pigs. (5036157)
1972
37
In vitro demonstration of delayed hypersensitivity in patients with berylliosis. (5061834)
1972
38
Immunoglobulin concentrationsn berylliosis. (4191591)
1970
39
Immunoglobulin levels in berylliosis. (4129664)
1970
40
The role of immunologic reactions in pulmonary berylliosis. (5527729)
1970
41
Serological reactions of berylliosis patients to extracts of lung tissue. (5644743)
1968
42
Pulmonary berylliosis: a case report. (6083249)
1967
43
Chronic berylliosis and calcospherite deposition. (5901642)
1966
44
PROBABLE BERYLLIOSIS FROM BERYLLIUM ALLOYS. (14185553)
1964
45
Berylliosis: report of two cases, with special reference to the patch test. (13938965)
1963
46
Chronic berylliosis. (14498247)
1962
47
The mineral content of the lung in chronic berylliosis. (13991590)
1962
48
Experimental berylliosis. I. Effects of a single intradermal injection of beryllium nitrate into guinea pigs. (13761591)
1961
49
Chronic pulmonary berylliosis in a female chemist. (13773748)
1961
50
The intravenous use of ethylenediamine tetraacetic acid in the treatment of pulmonary berylliosis. A case report. (13768361)
1960

Variations for Berylliosis

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Expression for genes affiliated with Berylliosis

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Search GEO for disease gene expression data for Berylliosis.

Pathways for genes affiliated with Berylliosis

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Pathways related to Berylliosis according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IFNG, IL2
29.6IFNG, IL2
3
Show member pathways
9.6IFNG, IL2
49.6IFNG, IL2
59.6IFNG, IL2
69.6IFNG, IL2
79.6IFNG, IL2
89.6IFNG, IL2
9
Show member pathways
9.6IFNG, IL2
109.6IFNG, IL2
119.6IFNG, IL2
129.3HLA-DPB1, HLA-DRB1
139.1HLA-DRB1, IFNG, IL2
14
Show member pathways
9.1HLA-DRB1, IFNG, IL2
159.1HLA-DRB1, IFNG, IL2
168.9HLA-DPB1, HLA-DRB1, IFNG
17
Show member pathways
8.9HLA-DPB1, HLA-DRB1, IFNG
188.9HLA-DPB1, HLA-DRB1, IFNG
19
Show member pathways
8.9HLA-DPB1, HLA-DRB1, IFNG
208.9HLA-DPB1, HLA-DRB1, IFNG
218.9HLA-DPB1, HLA-DRB1, IL2
228.8IFNG, IL2, POMC
23
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2
24
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2
25
Show member pathways
8.5HLA-DPB1, HLA-DRB1, IFNG, IL2

GO Terms for genes affiliated with Berylliosis

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Cellular components related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.9HLA-DPB1, HLA-DRB1
2endocytic vesicle membraneGO:00306669.9HLA-DPB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.9HLA-DPB1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.9HLA-DPB1, HLA-DRB1
5MHC class II protein complexGO:00426139.9HLA-DPB1, HLA-DRB1
6trans-Golgi network membraneGO:00325889.8HLA-DPB1, HLA-DRB1
7transport vesicle membraneGO:00306589.3HLA-DPB1, HLA-DRB1

Biological processes related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL2
2positive regulation of interferon-gamma productionGO:003272910.0HLA-DPB1, IL2
3T cell costimulationGO:00312959.9HLA-DPB1, HLA-DRB1
4positive regulation of T cell proliferationGO:00421029.6HLA-DPB1, IFNG, IL2
5interferon-gamma-mediated signaling pathwayGO:00603339.5HLA-DPB1, HLA-DRB1, IFNG
6T cell receptor signaling pathwayGO:00508528.9HLA-DPB1, HLA-DRB1, IFNG

Molecular functions related to Berylliosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.3HLA-DPB1, HLA-DRB1

Sources for Berylliosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet