MCID: BLT006
MIFTS: 40

Bilateral Breast Cancer malady

Cancer diseases category

Aliases & Classifications for Bilateral Breast Cancer

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt
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Bilateral Breast Cancer, Aliases & Descriptions:

Name: Bilateral Breast Cancer 9 43 60
 
Bilateral Breast Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:6741
NCIt38 C8287

Summaries for Bilateral Breast Cancer

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Disease Ontology:9 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and gynecomastia. An important gene associated with Bilateral Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and FOXM1 transcription factor network. The compounds daidzein and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and small intestine, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Related Diseases for Bilateral Breast Cancer

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Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.8PGR, BRCA1, BRCA2
2gynecomastia30.4BRCA2, BRCA1, PGR
3ductal carcinoma in situ30.2BRCA2, BRCA1, PGR
4li-fraumeni syndrome30.1PGR, BRCA1, BRCA2
5hodgkin lymphoma29.9BRCA1, BRCA2, ATM
6prostate cancer29.6ATM, BRCA2, BRCA1, CHEK2, RAD51
7adenocarcinoma29.4RAD51, CHEK2, PGR, BRCA1, BRCA2
8ataxia-telangiectasia29.3ATM, BRCA2, BRCA1, CHEK2, RAD51
9leukemia29.2ATM, BRCA2, BRCA1, CHEK2, RAD51
10synchronous bilateral breast carcinoma10.6
11cystadenoma10.4BRCA1
12hereditary breast ovarian cancer10.4BRCA2
13peutz-jeghers syndrome10.3
14prostatitis10.3
15brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
16fallopian tube cancer10.2BRCA2, BRCA1
17peritoneal carcinoma10.2BRCA1, BRCA2
18dysgerminoma10.2BRCA2, BRCA1
19cowden disease10.2BRCA1, BRCA2
20lynch syndrome10.2BRCA1, BRCA2
21breast ductal carcinoma10.1PGR, BRCA1
22endometrial adenocarcinoma10.1
23hepatocellular carcinoma10.1
24asthma10.1
25kindler syndrome10.1
26burns10.1
27klinefelter's syndrome10.1
28diffuse scleroderma10.1
29papillary serous adenocarcinoma10.1
30sporadic breast cancer10.1
31duodenitis10.1
32graves' disease10.1
33crest syndrome10.1
34angiosarcoma10.1
35dermatomyositis10.1
36lymphoblastic leukemia10.1
37peritonitis10.1
38scleroderma10.1
39malignant mixed mullerian tumor10.1
40ataxia10.1
41paraneoplastic syndromes10.1
42papillary carcinoma10.0PGR, BRCA2
43werner syndrome10.0ATM, BRCA1
44aplastic anemia10.0BRCA2, BRCA1, RAD51
45endometrial cancer10.0PGR, BRCA1, BRCA2
46retinoblastoma9.9BRCA2, BRCA1, CHEK2
47nijmegen breakage syndrome9.9ATM, BRCA1, CHEK2
48ovarian cancer, somatic9.9PGR, BRCA1, BRCA2
49gastric cancer, somatic9.9BRCA2, BRCA1, CHEK2
50chronic lymphocytic leukemia9.9BRCA2, ATM

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Symptoms for Bilateral Breast Cancer

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Drugs & Therapeutics for Bilateral Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

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MalaCards organs/tissues related to Bilateral Breast Cancer:

31
Breast, Prostate, Small intestine, Lung, Ovary, Testes, Cervix, Pituitary

Animal Models for Bilateral Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Bilateral Breast Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0PGR, BRCA1, BRCA2
2MP:00053798.1PGR, BRCA1, BRCA2, ATM
3MP:00020067.9CHEK2, PGR, BRCA1, BRCA2, ATM
4MP:00053897.9ATM, BRCA2, BRCA1, PGR
5MP:00053977.8ATM, BRCA2, BRCA1, PGR, CHEK2
6MP:00053877.7ATM, BRCA2, BRCA1, PGR, CHEK2
7MP:00053807.7ATM, BRCA2, BRCA1, PGR, RAD51
8MP:00053847.3ATM, BRCA2, BRCA1, PGR, CHEK2, RAD51
9MP:00107687.2ATM, BRCA2, BRCA1, PGR, CHEK2, RAD51

Publications for Bilateral Breast Cancer

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Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. (25605345)
2015
2
A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer. (24498881)
2014
3
Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. (25007962)
2014
4
Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. (25112434)
2014
5
Synchronous bilateral breast cancer in a male. (24319497)
2013
6
Histo-biological comparative analysis of bilateral breast cancer. (24062258)
2013
7
The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. (23296702)
2013
8
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. (23104382)
2013
9
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer. (24382440)
2013
10
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (21989022)
2011
11
Bilateral breast cancer in a survivor of acute lymphoblastic leukemia: a case report. (19472087)
2010
12
A novel de novo BRCA2 mutation of paternal origin identified in a Spanish woman with early onset bilateral breast cancer. (19649703)
2010
13
Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women. (19190627)
2009
14
Prognosis of synchronous bilateral breast cancer. (19283743)
2009
15
Synchronous bilateral breast cancer in a male patient following hormone therapy for prostate cancer. (19593618)
2009
16
Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study. (18432183)
2009
17
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (19153073)
2009
18
Oncoplastic surgery after mammary reduction and mastopexy for bilateral breast cancer lesions: report of a case. (18368323)
2008
19
Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. (16544057)
2006
20
A case of metachronous bilateral breast cancer with bilateral radiation pneumonitis after breast-conserving therapy. (16929127)
2006
21
A comparison of bilateral breast cancers in BRCA carriers. (15941968)
2005
22
A case of bilateral breast cancer and Graves' disease. (15656338)
2004
23
BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients. (15319244)
2004
24
Paclitaxel chemotherapy in a pregnant patient with bilateral breast cancer. (15507181)
2004
25
Biopathological profile of multiple synchronous homolateral and bilateral breast cancers. (15157045)
2004
26
Molecular pathogenesis of bilateral breast cancer. (12609703)
2003
27
Bilateral breast cancer associated with diffuse scleroderma. (14659331)
2003
28
Synchronous, bilateral breast cancer: prognostic value and incidence. (14659335)
2003
29
The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. (12099647)
2002
30
Prognostic significance of synchronous and metachronous bilateral breast cancer. (11571945)
2001
31
BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age. (11389159)
2001
32
Bilateral breast cancer--under age 20 years. (11287255)
2001
33
Diet and premenopausal bilateral breast cancer: a case-control study. (9065608)
1997
34
Early-stage bilateral breast cancer treated with breast-conserving surgery and definitive irradiation: the University of Pennsylvania experience. (9276360)
1997
35
Clonal analysis of bilateral breast cancer. (9816225)
1996
36
Bilateral breast cancer: early detection with mammography. (7617856)
1995
37
Clinical epidemiology of bilateral breast cancer. (8252478)
1993
38
Absence of p53 germ-line mutations in bilateral breast cancer patients. (1587536)
1992
39
Genetic epidemiology of bilateral breast cancer: a linkage analysis using the affected-pedigree-member method. (2328913)
1990
40
Bilateral breast cancer: the frequency of undiagnosed cancers. (3017110)
1986
41
Bilateral breast cancer in patients with initial stage I and II disease. (7104963)
1982
42
Bilateral breast cancer in a Chinese male. (6274288)
1981
43
Bilateral breast cancer and familial aggregations. (674108)
1978
44
Simultaneous bilateral breast cancer. (852934)
1977
45
Bilateral breast cancer: biopsy of the opposite breast. (907998)
1977
46
Bilateral breast cancer what about the other breast? (1012550)
1976
47
Bilateral breast cancer. (5389668)
1969
48
Bilateral breast cancer in relation to the menses. (5811574)
1969
49
Bilateral breast cancer. (13176685)
1954
50
Bilateral breast cancer. (18143507)
1949

Variations for Bilateral Breast Cancer

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Expression for genes affiliated with Bilateral Breast Cancer

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Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

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Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.6BRCA1, CHEK2
29.5CHEK2, BRCA2
3
Show member pathways
9.3RAD51, BRCA2
49.2BRCA1, ATM
59.2BRCA1, ATM
69.2BRCA1, ATM
7
Show member pathways
Cell cycle36
9.2CHEK2, ATM
8
Show member pathways
9.2CHEK2, ATM
9
Show member pathways
p53 pathway36
9.2ATM, CHEK2
10
Show member pathways
9.2CHEK2, ATM
119.1ATM, PGR
128.9RAD51, BRCA1, BRCA2
13
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.8ATM, BRCA1, CHEK2
14
Show member pathways
8.8CHEK2, BRCA1, ATM
15
Show member pathways
8.8CHEK2, BRCA1, ATM
168.8ATM, BRCA1, CHEK2
178.8ATM, BRCA1, CHEK2
18
Show member pathways
8.7ATM, BRCA2, BRCA1
19
Show member pathways
Signaling Pathways in Glioblastoma36
8.7ATM, BRCA2, BRCA1
208.6RAD51, BRCA1, ATM
21
Show member pathways
Homologous recombination36
8.5RAD51, BRCA2, ATM
22
Show member pathways
8.2ATM, BRCA1, CHEK2, RAD51
23
Show member pathways
DNA damage response36
8.2RAD51, CHEK2, BRCA1, ATM
24
Show member pathways
ATM Signaling Pathway36
8.2RAD51, CHEK2, BRCA1, ATM
25
Show member pathways
8.1ATM, BRCA2, BRCA1, RAD51
26
Show member pathways
8.1ATM, BRCA2, BRCA1, RAD51
277.6RAD51, CHEK2, BRCA1, BRCA2, ATM
28
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51
297.6RAD51, CHEK2, BRCA1, BRCA2, ATM
30
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51
317.6ATM, BRCA2, BRCA1, CHEK2, RAD51
32
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51

Compounds for genes affiliated with Bilateral Breast Cancer

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Compounds related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1daidzein439.9BRCA1, BRCA2
28-oxoguanine439.9BRCA1, BRCA2
3lycopene43 2410.8BRCA1, BRCA2
4indole-3-carbinol439.8BRCA2, BRCA1
517beta-hydroxysteroid439.7PGR, BRCA1
6o6-methylguanine439.6RAD51, BRCA2
7nocodazole43 1210.6CHEK2, BRCA1
8neocarzinostatin439.6ATM, CHEK2
9topotecan43 1210.5BRCA1, ATM
104-hydroxytamoxifen439.4PGR, BRCA1, BRCA2
11resveratrol43 59 24 1212.4PGR, BRCA1, BRCA2
12docetaxel43 49 59 1212.4BRCA2, BRCA1, PGR
13folate439.4BRCA2, BRCA1, PGR
14gemcitabine43 49 1211.4RAD51, CHEK2, BRCA1
15methotrexate49 43 1211.4PGR, BRCA1, BRCA2
16methylmethanesulfonate439.3BRCA2, BRCA1, RAD51
17tamoxifen43 49 28 1212.3BRCA2, BRCA1, PGR
18gold439.3RAD51, BRCA1, BRCA2
19estradiol43 24 1211.3PGR, BRCA1, BRCA2
20adpribose439.2BRCA1, BRCA2
21bpde439.2ATM, BRCA1, CHEK2
22progesterone43 28 59 24 1213.1PGR, BRCA1, BRCA2
23bleomycin43 1210.1BRCA1, BRCA2, ATM
24thymidine43 2410.1BRCA2, BRCA1, RAD51
25testosterone43 59 24 1212.0BRCA2, BRCA1, PGR
26adriamycin439.0BRCA2, BRCA1, PGR, CHEK2
27h2o2439.0RAD51, BRCA1, BRCA2
28steroid438.9PGR, BRCA1, BRCA2
29retinoic acid43 249.9BRCA2, BRCA1, PGR, CHEK2
30wortmannin438.8ATM, CHEK2, RAD51
31oligonucleotide438.8RAD51, CHEK2, BRCA1, BRCA2
32paclitaxel43 49 1210.8RAD51, PGR, BRCA1, BRCA2
33alanine438.8BRCA1, PGR, CHEK2, RAD51
34cycloheximide438.8BRCA2, BRCA1, PGR, RAD51
35doxorubicin43 49 1210.7ATM, BRCA1, PGR, CHEK2
36phosphatidylinositol438.6ATM, BRCA2, BRCA1, CHEK2
37aphidicolin438.6ATM, BRCA1, CHEK2, RAD51
38paraffin438.6ATM, BRCA2, BRCA1, PGR
39glutamine438.6ATM, BRCA2, BRCA1, PGR
40caffeine43 28 2 49 24 1213.6RAD51, CHEK2, BRCA1, ATM
41mitomycin c438.5RAD51, BRCA1, BRCA2, ATM
42polyacrylamide438.5RAD51, BRCA1, BRCA2, ATM
43atp43 289.5ATM, BRCA1, CHEK2, RAD51
44tyrosine438.3ATM, BRCA1, CHEK2, RAD51
45genistein43 28 59 2 24 1213.2ATM, BRCA2, BRCA1, PGR, CHEK2
46hydroxyurea43 49 1210.1RAD51, CHEK2, BRCA1, BRCA2, ATM
47camptothecin43 59 1210.1ATM, BRCA2, BRCA1, CHEK2, RAD51
48etoposide43 49 59 1211.1RAD51, CHEK2, BRCA1, BRCA2, ATM
49cisplatin43 49 59 1211.1ATM, BRCA2, BRCA1, CHEK2, RAD51
50estrogen438.0ATM, BRCA2, BRCA1, PGR, RAD51

GO Terms for genes affiliated with Bilateral Breast Cancer

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Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166059.4RAD51, CHEK2
2chromosome, telomeric regionGO:00007818.9CHEK2, ATM
3nucleoplasmGO:00056547.0RAD51, ATM, BRCA2, BRCA1, PGR, CHEK2

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.6BRCA1, BRCA2
2response to gamma radiationGO:00103329.5BRCA2, CHEK2
3DNA damage induced protein phosphorylationGO:00069759.3CHEK2, ATM
4replicative senescenceGO:00903999.3CHEK2, ATM
5positive regulation of transcription, DNA-templatedGO:00458939.1CHEK2, BRCA1, BRCA2
6intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.0ATM, BRCA1, CHEK2
7response to ionizing radiationGO:00102128.9BRCA1, ATM
8reciprocal meiotic recombinationGO:00071318.9RAD51, ATM
9cellular response to DNA damage stimulusGO:00069748.4ATM, BRCA1, CHEK2, RAD51
10double-strand break repair via homologous recombinationGO:00007248.3ATM, BRCA2, BRCA1, RAD51
11DNA repairGO:00062818.3RAD51, BRCA1, BRCA2, ATM
12double-strand break repairGO:00063027.9RAD51, CHEK2, BRCA1, BRCA2, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:00036979.3RAD51, BRCA2
2protein bindingGO:00055156.8RAD51, CHEK2, PGR, BRCA1, BRCA2, ATM

Products for genes affiliated with Bilateral Breast Cancer

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  • Antibodies
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  • Proteins
  • Kits and Assays

Sources for Bilateral Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet