MCID: BLT006
MIFTS: 48

Bilateral Breast Cancer malady

Cancer diseases category
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Summaries for Bilateral Breast Cancer

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and gynecomastia. An important gene associated with Bilateral Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and FOXM1 transcription factor network. The compounds daidzein and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include breast, small intestine and lung, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Bilateral Breast Cancer

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

bilateral breast cancer 8 45 62
bilateral breast carcinoma 8


External Ids:

Disease Ontology8 DOID:6741
NCIt40 C8287

Related Diseases for Bilateral Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7BRCA2, BRCA1, PGR
2gynecomastia30.3BRCA2, BRCA1, PGR
3ductal carcinoma in situ30.1PGR, BRCA2, BRCA1
4li-fraumeni syndrome30.1BRCA1, PGR, BRCA2
5adenocarcinoma29.9BRCA2, BRCA1, PGR, CHEK2, RAD51
6ataxia telangiectasia29.9CHEK2, BRCA1, BRCA2, ATM, RAD51
7prostate cancer29.9BRCA1, CHEK2, BRCA2, ATM, RAD51
8leukemia29.9RAD51, CHEK2, BRCA1, BRCA2, ATM
9synchronous bilateral breast carcinoma10.6
10peutz-jeghers syndrome10.3
11cystadenoma10.1BRCA1
12breast-ovarian cancer, familial, 210.1BRCA2
13endometrial adenocarcinoma10.1
14burns10.1
15klinefelter's syndrome10.1
16diffuse scleroderma10.1
17papillary serous adenocarcinoma10.1
18sporadic breast cancer10.1
19duodenitis10.1
20graves' disease10.1
21angiosarcoma10.1
22asthma10.1
23dermatomyositis10.1
24hepatocellular carcinoma10.1
25lymphoblastic leukemia10.1
26osteosarcoma10.1
27peritonitis10.1
28prostatitis10.1
29scleroderma10.1
30kindler syndrome10.1
31malignant mixed mullerian tumor10.1
32ataxia10.1
33paraneoplastic syndromes10.1
34brca1 and brca2 hereditary breast and ovarian cancer10.1BRCA2, BRCA1
35fallopian tube cancer10.0BRCA1, BRCA2
36peritoneal carcinoma10.0BRCA1, BRCA2
37familial colorectal cancer10.0BRCA2, BRCA1
38dysgerminoma10.0BRCA1, BRCA2
39cowden disease10.0BRCA2, BRCA1
40lynch syndrome10.0BRCA2, BRCA1
41male breast cancer10.0BRCA2, BRCA1, PGR
42papillary carcinoma10.0PGR, BRCA2
43werner syndrome10.0ATM, BRCA1
44aplastic anemia10.0BRCA1, BRCA2, RAD51
45endometrial carcinoma10.0BRCA1, BRCA2, PGR
46retinoblastoma10.0BRCA1, CHEK2, BRCA2
47nijmegen breakage syndrome10.0BRCA1, CHEK2, ATM
48ovarian cancer10.0BRCA1, PGR, BRCA2
49stomach cancer10.0BRCA1, CHEK2, BRCA2
50breast cancer, invasive ductal10.0PGR, ATM, BRCA1

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Symptoms for Bilateral Breast Cancer

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Drugs & Therapeutics for Bilateral Breast Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

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Sources:
33MalaCards
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MalaCards organs/tissues related to Bilateral Breast Cancer:

33
Breast, Small intestine, Lung, Ovary, Prostate, Testes, Cervix, Pituitary

Animal Models for Bilateral Breast Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bilateral Breast Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0PGR, BRCA1, BRCA2
2MP:00053798.1PGR, BRCA1, BRCA2, ATM
3MP:00020067.9CHEK2, PGR, BRCA1, BRCA2, ATM
4MP:00053897.9ATM, BRCA2, BRCA1, PGR
5MP:00053977.8ATM, BRCA2, BRCA1, PGR, CHEK2
6MP:00053877.7ATM, BRCA2, BRCA1, PGR, CHEK2
7MP:00053807.7ATM, BRCA2, BRCA1, PGR, RAD51
8MP:00053847.3ATM, BRCA2, BRCA1, PGR, CHEK2, RAD51
9MP:00107687.2ATM, BRCA2, BRCA1, PGR, CHEK2, RAD51

Publications for Bilateral Breast Cancer

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Sources:
52PubMed
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Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 170)
idTitleAuthorsYear
1
Synchronous bilateral breast cancer in a male. (24319497)
2013
2
Histo-biological comparative analysis of bilateral breast cancer. (24062258)
2013
3
The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. (23296702)
2013
4
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. (23104382)
2013
5
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer. (24382440)
2013
6
A case of synchronous bilateral breast cancer with different pathological responses to neoadjuvant chemotherapy with different biological character. (23875131)
2013
7
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (21989022)
2011
8
Bilateral breast cancer in a survivor of acute lymphoblastic leukemia: a case report. (19472087)
2010
9
A novel de novo BRCA2 mutation of paternal origin identified in a Spanish woman with early onset bilateral breast cancer. (19649703)
2010
10
Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women. (19190627)
2009
11
Prognosis of synchronous bilateral breast cancer. (19283743)
2009
12
Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study. (18432183)
2009
13
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (19153073)
2009
14
Oncoplastic surgery after mammary reduction and mastopexy for bilateral breast cancer lesions: report of a case. (18368323)
2008
15
Clinical course of 771 patients with bilateral breast cancer: characteristics associated with overall and recurrence-free survival. (18269777)
2007
16
Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. (16544057)
2006
17
A case of metachronous bilateral breast cancer with bilateral radiation pneumonitis after breast-conserving therapy. (16929127)
2006
18
A comparison of bilateral breast cancers in BRCA carriers. (15941968)
2005
19
A case of bilateral breast cancer and Graves' disease. (15656338)
2004
20
BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients. (15319244)
2004
21
Paclitaxel chemotherapy in a pregnant patient with bilateral breast cancer. (15507181)
2004
22
Biopathological profile of multiple synchronous homolateral and bilateral breast cancers. (15157045)
2004
23
Molecular pathogenesis of bilateral breast cancer. (12609703)
2003
24
Bilateral breast cancer associated with diffuse scleroderma. (14659331)
2003
25
Synchronous, bilateral breast cancer: prognostic value and incidence. (14659335)
2003
26
Malignant mixed mullerian tumor of the ovary and bilateral breast cancer: an argument for BRCA3, or a coincidental cluster of unconnected cancers? (14599878)
2003
27
The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. (12099647)
2002
28
Prognostic significance of synchronous and metachronous bilateral breast cancer. (11571945)
2001
29
BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age. (11389159)
2001
30
Bilateral breast cancer--under age 20 years. (11287255)
2001
31
Diet and premenopausal bilateral breast cancer: a case-control study. (9065608)
1997
32
Early-stage bilateral breast cancer treated with breast-conserving surgery and definitive irradiation: the University of Pennsylvania experience. (9276360)
1997
33
Clonal analysis of bilateral breast cancer. (9816225)
1996
34
Bilateral breast cancer: early detection with mammography. (7617856)
1995
35
Clinical epidemiology of bilateral breast cancer. (8252478)
1993
36
Absence of p53 germ-line mutations in bilateral breast cancer patients. (1587536)
1992
37
Genetic epidemiology of bilateral breast cancer: a linkage analysis using the affected-pedigree-member method. (2328913)
1990
38
Possible heterogeneity in the segregation pattern of breast cancer in families with bilateral breast cancer. (3402724)
1988
39
Bilateral breast cancer: the frequency of undiagnosed cancers. (3017110)
1986
40
Bilateral breast cancer in northern Alberta: risk factors and survival patterns. (6322952)
1984
41
Bilateral breast cancer in patients with initial stage I and II disease. (7104963)
1982
42
Bilateral breast cancer in a Chinese male. (6274288)
1981
43
Bilateral breast cancer and familial aggregations. (674108)
1978
44
Simultaneous bilateral breast cancer. (852934)
1977
45
Bilateral breast cancer: biopsy of the opposite breast. (907998)
1977
46
Bilateral breast cancer what about the other breast? (1012550)
1976
47
Bilateral breast cancer. (5389668)
1969
48
Bilateral breast cancer in relation to the menses. (5811574)
1969
49
Bilateral breast cancer. (13176685)
1954
50
Bilateral breast cancer. (18143507)
1949

Variations for Bilateral Breast Cancer

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Expression for genes affiliated with Bilateral Breast Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53QIAGEN, 55Reactome, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.6BRCA1, CHEK2
29.5CHEK2, BRCA2
39.4RAD51, BRCA1
4
Show member pathways
9.3RAD51, BRCA2
59.2BRCA1, ATM
69.2BRCA1, ATM
79.2BRCA1, ATM
8
Show member pathways
Cell cycle38
9.2CHEK2, ATM
9
Show member pathways
9.2CHEK2, ATM
10
Show member pathways
p53 pathway38
9.2ATM, CHEK2
11
Show member pathways
9.2CHEK2, ATM
129.1ATM, PGR
138.9RAD51, BRCA1, BRCA2
14
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
8.8ATM, BRCA1, CHEK2
15
Show member pathways
8.8CHEK2, BRCA1, ATM
16
Show member pathways
8.8CHEK2, BRCA1, ATM
178.8ATM, BRCA1, CHEK2
188.8ATM, BRCA1, CHEK2
19
Show member pathways
8.7ATM, BRCA2, BRCA1
20
Show member pathways
Signaling Pathways in Glioblastoma38
8.7ATM, BRCA2, BRCA1
218.6RAD51, BRCA1, ATM
22
Show member pathways
Homologous recombination38
8.5RAD51, BRCA2, ATM
23
Show member pathways
8.2ATM, BRCA1, CHEK2, RAD51
24
Show member pathways
DNA damage response38
8.2RAD51, CHEK2, BRCA1, ATM
25
Show member pathways
ATM Signaling Pathway38
8.2RAD51, CHEK2, BRCA1, ATM
26
Show member pathways
8.1ATM, BRCA2, BRCA1, RAD51
27
Show member pathways
8.1ATM, BRCA2, BRCA1, RAD51
28
Show member pathways
8.1RAD51, BRCA1, BRCA2, ATM
297.6RAD51, CHEK2, BRCA1, BRCA2, ATM
30
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51
317.6RAD51, CHEK2, BRCA1, BRCA2, ATM
32
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51
337.6ATM, BRCA2, BRCA1, CHEK2, RAD51
34
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51

Compounds for genes affiliated with Bilateral Breast Cancer

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 3BitterDB
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Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1daidzein459.9BRCA1, BRCA2
28-oxoguanine459.9BRCA1, BRCA2
3lycopene45 2410.8BRCA1, BRCA2
4indole-3-carbinol459.8BRCA2, BRCA1
517beta-hydroxysteroid459.7PGR, BRCA1
6o6-methylguanine459.6RAD51, BRCA2
7nocodazole45 1110.6CHEK2, BRCA1
8neocarzinostatin459.6ATM, CHEK2
9topotecan45 1110.5BRCA1, ATM
104-hydroxytamoxifen459.4PGR, BRCA1, BRCA2
11resveratrol45 61 24 1112.4PGR, BRCA1, BRCA2
12docetaxel45 51 61 1112.4BRCA2, BRCA1, PGR
13folate459.4BRCA2, BRCA1, PGR
14gemcitabine45 51 1111.4RAD51, CHEK2, BRCA1
15methotrexate51 45 1111.4PGR, BRCA1, BRCA2
16methylmethanesulfonate459.3BRCA2, BRCA1, RAD51
17tamoxifen45 51 29 1112.3BRCA2, BRCA1, PGR
18gold459.3RAD51, BRCA1, BRCA2
19estradiol45 24 1111.3PGR, BRCA1, BRCA2
20adpribose459.2BRCA1, BRCA2
21bpde459.2ATM, BRCA1, CHEK2
22progesterone45 29 61 24 1113.1PGR, BRCA1, BRCA2
23bleomycin45 1110.1BRCA1, BRCA2, ATM
24thymidine45 2410.1BRCA2, BRCA1, RAD51
25testosterone45 61 24 1112.0BRCA2, BRCA1, PGR
26adriamycin459.0BRCA2, BRCA1, PGR, CHEK2
27h2o2459.0RAD51, BRCA1, BRCA2
28steroid458.9PGR, BRCA1, BRCA2
29retinoic acid45 249.9BRCA2, BRCA1, PGR, CHEK2
30wortmannin458.8ATM, CHEK2, RAD51
31oligonucleotide458.8RAD51, CHEK2, BRCA1, BRCA2
32paclitaxel45 51 1110.8RAD51, PGR, BRCA1, BRCA2
33alanine458.8BRCA1, PGR, CHEK2, RAD51
34cycloheximide458.8BRCA2, BRCA1, PGR, RAD51
35doxorubicin45 51 1110.7ATM, BRCA1, PGR, CHEK2
36phosphatidylinositol458.6ATM, BRCA2, BRCA1, CHEK2
37aphidicolin458.6ATM, BRCA1, CHEK2, RAD51
38paraffin458.6ATM, BRCA2, BRCA1, PGR
39glutamine458.6ATM, BRCA2, BRCA1, PGR
40caffeine45 29 3 51 24 1113.6RAD51, CHEK2, BRCA1, ATM
41mitomycin c458.5RAD51, BRCA1, BRCA2, ATM
42polyacrylamide458.5RAD51, BRCA1, BRCA2, ATM
43atp45 299.5ATM, BRCA1, CHEK2, RAD51
44tyrosine458.3ATM, BRCA1, CHEK2, RAD51
45genistein45 29 61 3 24 1113.2ATM, BRCA2, BRCA1, PGR, CHEK2
46hydroxyurea45 51 1110.1RAD51, CHEK2, BRCA1, BRCA2, ATM
47camptothecin45 61 1110.1ATM, BRCA2, BRCA1, CHEK2, RAD51
48etoposide45 51 61 1111.1RAD51, CHEK2, BRCA1, BRCA2, ATM
49cisplatin45 51 61 1111.1ATM, BRCA2, BRCA1, CHEK2, RAD51
50estrogen458.0ATM, BRCA2, BRCA1, PGR, RAD51

GO Terms for genes affiliated with Bilateral Breast Cancer

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16Gene Ontology
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Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.4RAD51, CHEK2
2chromosome, telomeric regionGO:0007818.9CHEK2, ATM
3nucleoplasmGO:0056547.0RAD51, ATM, BRCA2, BRCA1, PGR, CHEK2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.6BRCA1, BRCA2
2response to gamma radiationGO:0103329.5BRCA2, CHEK2
3DNA damage induced protein phosphorylationGO:0069759.3CHEK2, ATM
4replicative senescenceGO:0903999.3CHEK2, ATM
5positive regulation of transcription, DNA-templatedGO:0458939.1CHEK2, BRCA1, BRCA2
6intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.0ATM, BRCA1, CHEK2
7response to ionizing radiationGO:0102128.9BRCA1, ATM
8reciprocal meiotic recombinationGO:0071318.9RAD51, ATM
9cellular response to DNA damage stimulusGO:0069748.4ATM, BRCA1, CHEK2, RAD51
10double-strand break repair via homologous recombinationGO:0007248.3ATM, BRCA2, BRCA1, RAD51
11DNA repairGO:0062818.3RAD51, BRCA1, BRCA2, ATM
12double-strand break repairGO:0063027.9RAD51, CHEK2, BRCA1, BRCA2, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.3RAD51, BRCA2
2protein bindingGO:0055156.8RAD51, CHEK2, PGR, BRCA1, BRCA2, ATM

Products for genes affiliated with Bilateral Breast Cancer

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  • Antibodies
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  • Antibodies

Sources for Bilateral Breast Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet