MCID: BLT006
MIFTS: 47

Bilateral Breast Cancer malady

Cancer category

Summaries for Bilateral Breast Cancer

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to male breast cancer and oral cancer. An important gene associated with Bilateral Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are FOXM1 transcription factor network and Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. The compounds cycloheximide and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include ovary, lymph node and lung, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Bilateral Breast Cancer

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

bilateral breast cancer 8 45 61
bilateral breast carcinoma 8


External Ids:

Disease Ontology8 DOID:6741
NCIt40 C8287

Related Diseases for Bilateral Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the breast cancer family:

bilateral breast cancer familial breast cancer
breast cancer, type 3 breast cancer, early-onset

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1male breast cancer30.8PGR, BRCA2, BRCA1, ESR1
2oral cancer30.3GSTP1, FHIT
3gynecomastia30.3BRCA2, BRCA1, PGR, ESR1
4li-fraumeni syndrome30.1ESR1, PGR
5malignant mixed mullerian tumor30.1PGR, ESR1
6ductal carcinoma in situ30.1BRCA2, ESR1, BRCA1, PGR
7breast cancer, invasive ductal30.1ESR1, PGR, BRCA1, ATM
8acute leukemia30.1ACP1, ATM, GSTP1, FHIT
9ataxia telangiectasia30.1CHEK2, BRCA1, RAD51, ATM, BRCA2, DRD2
10adenocarcinoma30.0FHIT, BRCA2, MLH1, BRCA1, CHEK2, HIC1
11breast cancer, early-onset10.4
12familial breast cancer10.4
13peutz-jeghers syndrome10.3
14peutz–jeghers syndrome10.3
15breast reconstruction10.1
16papillary serous adenocarcinoma10.1
17diffuse scleroderma10.1
18klinefelter's syndrome10.1
19breast osteosarcoma10.1
20sporadic breast cancer10.1
21synchronous bilateral breast carcinoma10.1
22graves' disease10.1
23breast angiosarcoma10.1
24angiosarcoma10.1
25asthma10.1
26breast adenocarcinoma10.1
27kindler syndrome10.1
28ataxia10.1
29breast cancer susceptibility10.1
30breast cancer, lobular10.1
31breast lymphoma10.1
32deficiency anemia10.0BRCA1
33breast-ovarian cancer, familial, 210.0BRCA2
34infertility10.0ESR1
35thyroid cancer10.0FHIT
36leiomyosarcoma10.0PGR
37myeloid leukemia10.0ACP1
38gallbladder cancer10.0MLH1
39osteosarcoma10.0ESR1, CHEK2
40papilloma10.0FHIT
41endometriosis10.0PGR, ESR1
42brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA1, BRCA2
43leiomyoma10.0PGR, ESR1
44peritoneal carcinoma10.0BRCA1, BRCA2
45cerebral meningioma10.0PGR
46cystadenoma10.0BRCA1
47fallopian tube cancer10.0BRCA1, BRCA2
48pancreatitis10.0BRCA2, GSTP1
49meningioma10.0PGR, ESR1
50progesterone resistance10.0ESR1, PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Clinical Features for Bilateral Breast Cancer

Drugs & Therapeutics for Bilateral Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bilateral Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Search CenterWatch for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

Anatomical Context for Bilateral Breast Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bilateral Breast Cancer:

33
Ovary, Lymph node, Lung, Whole blood, Small intestine, Breast, Prostate, Cervix, Pituitary

Animal Models for Bilateral Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bilateral Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Synchronous bilateral breast cancer in a male. (24319497)
2013
2
One-staged silicone implant breast reconstruction following bilateral nipple-sparing prophylactic mastectomy in patients at high-risk for breast cancer. (23322096)
2013
3
One-staged silicone implant breast reconstruction following bilateral nipple-sparing prophylactic mastectomy in patients at high risk for breast cancer. (23860821)
2013
4
A novel, validated method to quantify breast cancer-related lymphedema (BCRL) following bilateral breast surgery. (24354105)
2013
5
Ductal carcinoma in situ that involves sclerosing adenosis: high frequency of bilateral breast cancer occurrence. (23083502)
2012
6
Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer. (22520019)
2012
7
Pregnancy a short time after multimodal therapy for bilateral breast cancer: a case report and review of literature. (20858636)
2011
8
PALB2 mutations in German and Russian patients with bilateral breast cancer. (21165770)
2011
9
A case-match study comparing unilateral with synchronous bilateral breast cancer outcomes. (22105824)
2011
10
A novel de novo BRCA2 mutation of paternal origin identified in a Spanish woman with early onset bilateral breast cancer. (19649703)
2010
11
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation. (19955943)
2009
12
Synchronous bilateral breast cancer in a male patient following hormone therapy for prostate cancer. (19593618)
2009
13
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (19153073)
2009
14
Oncoplastic surgery after mammary reduction and mastopexy for bilateral breast cancer lesions: report of a case. (18368323)
2008
15
Case 32-2007: bilateral breast cancer. (18305276)
2008
16
Bilateral breast cancer in a male patient with hepatocellular carcinoma. A case report. (18727274)
2008
17
Bilateral male breast cancer: too many concerns? (18260745)
2007
18
Incidence and prognosis of synchronous and metachronous bilateral breast cancer. (17878475)
2007
19
Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. (16544057)
2006
20
A case of bilateral breast cancer with Peutz-Jeghers syndrome. (16246518)
2006
21
Breast-conserving therapy in patients with bilateral breast cancer: do today's treatment choices burn bridges for tomorrow? (15890578)
2005
22
Bilateral breast cancer. Incidence, diagnosis and histological patterns. (15900371)
2005
23
Association of common ATM polymorphism with bilateral breast cancer. (15756685)
2005
24
The pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization. (14654965)
2004
25
Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. (14981104)
2004
26
Molecular pathogenesis of bilateral breast cancer. (12609703)
2003
27
Synchronous, bilateral breast cancer: prognostic value and incidence. (14659335)
2003
28
Primary breast lymphoma, contralateral breast cancer, and bilateral Brenner tumors of the ovary. (12423812)
2002
29
Breast-conservation treatment for bilateral breast cancer in five Japanese women. (11956611)
2002
30
A male case of primary bilateral breast cancers during estrogen therapy for prostate cancer]. (11766369)
2001
31
CYP17 polymorphism in the groups of distinct breast cancer susceptibility: comparison of patients with the bilateral disease vs. monolateral breast cancer patients vs. middle-aged female controls vs. elderly tumor-free women. (10840158)
2000
32
Loss of heterozygosity in bilateral breast cancer. (11200774)
2000
33
BRCA1 and BRCA2 founder mutations in patients with bilateral breast cancer. (10573018)
1999
34
Mammographic and ultrasonographic findings in bilateral breast cancer: a comparative study. (9569339)
1998
35
Diet and premenopausal bilateral breast cancer: a case-control study. (9065608)
1997
36
Early-stage bilateral breast cancer treated with breast-conserving surgery and definitive irradiation: the University of Pennsylvania experience. (9276360)
1997
37
Bilateral breast cancer: early detection with mammography. (7617856)
1995
38
Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer. (8221639)
1993
39
Bilateral breast cancer. (1775816)
1991
40
A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. II. Linkage analysis. (2766568)
1989
41
Familial and sporadic breast cancer cases in Iceland: a comparison related to ABO blood groups and risk of bilateral breast cancer. (3170024)
1988
42
Tumor-associated antigens in bilateral breast cancer. (2437406)
1987
43
Elective whole-lung irradiation in osteosarcoma treatment: appearance of bilateral breast cancer in two long-term survivors. (3472355)
1987
44
Bilateral breast cancer and radiotherapy for asthma. (3966732)
1985
45
Bilateral breast cancer. Risk reduction by contralateral biopsy. (4004380)
1985
46
A family with Peutz-Jeghers syndrome and bilateral breast cancer. (7397644)
1980
47
Bilateral breast cancer associated with clomiphene. (73084)
1977
48
Bilateral breast cancer 10 years after an augmentation mammaplasty: case report. (4809558)
1974
49
Bilateral breast cancer. (13176685)
1954
50
Simultaneous bilateral breast cancer; a report of two cases. (13200080)
1954

Genetic Variations for Bilateral Breast Cancer

Expression for genes affiliated with Bilateral Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 56SinoBiological, 52QIAGEN, 30KEGG, 50PharmGKB, 4Cell Signaling Technology
See all sources

Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2BRCA2, CHEK2
2
Hide members
10.2CHEK2, ATM
3
Hide members
10.2BRCA2, RAD51
4
Hide members
10.2BRCA1, ATM
510.0CHEK2, BRCA1, ATM
6
Hide members
10.0ATM, BRCA1, CHEK2
710.0BRCA1, ATM, CHEK2
8
Hide members
10.0ATM, CHEK2, BRCA1
9
Hide members
10.0ATM, BRCA2, BRCA1
10
Hide members
10.0BRCA2, RAD51, ATM
1110.0PGR, MLH1, ATM
1210.0CHEK2, MLH1, GSTP1
139.9ATM, BRCA1, HIC1
149.9RAD51, BRCA1, ATM, CHEK2
15
Hide members
9.9BRCA1, RAD51, CHEK2, ATM
16
Hide members
9.9RAD51, BRCA1, BRCA2, ATM
17
Hide members
9.9RAD51, ATM, BRCA2, BRCA1
18
Hide members
9.9ATM, RAD51, BRCA2, BRCA1
19
Cell cycle Cell cycle (generic schema)
Hide members
9.9PGR, BRCA1, CHEK2, ESR1
209.8BRCA1, BRCA2, MLH1, RAD51
219.8BRCA2, MLH1, RAD51, GSTP1
229.7RAD51, CHEK2, BRCA2, BRCA1, ATM
23
Hide members
9.7RAD51, ATM, MLH1, BRCA2, BRCA1
24
Hide members
9.6BRCA1, ESR1, RAD51, CHEK2, ATM, BRCA2
259.6RAD51, CHEK2, ATM, BRCA2, ESR1, BRCA1
269.6RAD51, ATM, CHEK2, BRCA2, ESR1, BRCA1
27
Hide members
9.6ATM, RAD51, MLH1, BRCA2, BRCA1, CHEK2
28
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.6ATM, CHEK2, RAD51, MLH1, BRCA2, BRCA1

Compounds for genes affiliated with Bilateral Breast Cancer

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5BRCA1, BRCA2
2ici 1643844510.5ESR1, PGR
3Ethynodiol Diacetate1110.5ESR1, PGR
4resveratrol45 60 11 2413.5BRCA2, PGR
5Allylestrenol1110.4ESR1, PGR
6adriamycin4510.4PGR, GSTP1, CHEK2
7Etonogestrel1110.4PGR, ESR1
8daidzein4510.4BRCA2, ESR1, BRCA1
9idoxifene4510.4ESR1, PGR
10droloxifene4510.4ESR1, PGR, GSTP1
11nomegestrol acetate4510.3GSTP1, ESR1, PGR
12lycopene45 2411.3BRCA1, BRCA2, GSTP1
13h2o24510.3RAD51, ACP1
14bpde4510.3GSTP1, BRCA1, ATM, CHEK2
154-hydroxytamoxifen4510.2ESR1, PGR, BRCA2, BRCA1
16o6-methylguanine4510.2GSTP1, RAD51, MLH1, BRCA2
17bleomycin45 1111.2ATM, GSTP1, BRCA2, BRCA1
18gemcitabine45 50 1112.2CHEK2, MLH1, BRCA1, RAD51
19caffeine45 50 29 2 11 2415.2BRCA1, RAD51, CHEK2, ATM
20sodium bisulfite4510.2MLH1, BRCA1, FHIT, GSTP1
21hydroxyurea45 50 1112.2BRCA1, BRCA2, ATM, RAD51, CHEK2
22platinum45 5011.2GSTP1, BRCA1, MLH1
23triphenylethylene4510.2PGR, ESR1
24indole-3-carbinol4510.1BRCA1, BRCA2, ESR1
25aphidicolin4510.1RAD51, BRCA1, FHIT, ATM, CHEK2
26thymidylate4510.1GSTP1, RAD51, BRCA1, MLH1
27mitomycin c4510.1RAD51, ATM, BRCA2, GSTP1, BRCA1
28neocarzinostatin4510.1ATM, CHEK2
29docetaxel45 50 60 1113.1GSTP1, PGR, ESR1, BRCA1, BRCA2
30methotrexate45 50 1112.1BRCA1, BRCA2, ESR1, GSTP1, PGR
31methylmethanesulfonate4510.0RAD51, BRCA2, BRCA1
32folate4510.0PGR, MLH1, BRCA2, BRCA1, GSTP1
335fluorouracil4510.0MLH1, PGR, ESR1, BRCA1, GSTP1
34cyclophosphamide45 50 1112.0GSTP1, PGR, ESR1, BRCA1
35polyacrylamide459.9MLH1, FHIT, BRCA2, BRCA1, RAD51, ATM
36steroid459.9ESR1, FHIT, BRCA2, BRCA1
37adenine45 11 2411.9RAD51, MLH1, BRCA1, ACP1
38camptothecin45 60 1111.8RAD51, ATM, CHEK2, MLH1, BRCA2, BRCA1
39progesterone45 60 29 11 2413.7ESR1, MLH1, PGR, BRCA1, BRCA2, FHIT
40topotecan45 1110.7GSTP1, BRCA1, ATM
415-aza-2deoxycytidine459.6ESR1, GSTP1, BRCA1, PGR, FHIT, HIC1
42paclitaxel45 50 1111.6GSTP1, PGR, MLH1, BRCA2, BRCA1, FHIT
43paraffin459.6BRCA2, GSTP1, ESR1, BRCA1, PGR, ATM
44alanine459.6PGR, MLH1, CHEK2, GSTP1, BRCA1, RAD51
45etoposide45 50 60 1112.5RAD51, MLH1, ATM, CHEK2, BRCA2, BRCA1
46genistein45 29 60 2 11 2414.5GSTP1, ESR1, CHEK2, ACP1, ATM, BRCA2
47doxorubicin45 50 1111.5BRCA1, MLH1, ATM, PGR, ACP1, GSTP1
48vegf459.4DRD2, RAD51, GSTP1, ACP1, BRCA1, PGR
49retinoic acid45 2410.3ESR1, GSTP1, PGR, CHEK2, MLH1, BRCA2
50cisplatin45 50 60 1111.9BRCA2, GSTP1, BRCA1, FHIT, DRD2, MLH1

GO Terms for genes affiliated with Bilateral Breast Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4ESR1, RAD51, PGR, CHEK2, ATM, BRCA2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.3ATM, CHEK2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3reciprocal meiotic recombinationGO:00713110.1RAD51, ATM, MLH1
4double-strand break repair via homologous recombinationGO:00072410.1RAD51, ATM, BRCA2, BRCA1
5replicative senescenceGO:09039910.1CHEK2, ATM
6regulation of stress-activated MAPK cascadeGO:03287210.0NBR1, GSTP1
7response to DNA damage stimulusGO:00697410.0RAD51, BRCA1, ATM, CHEK2
8double-strand break repairGO:00630210.0BRCA1, BRCA2, ATM, CHEK2, RAD51
9DNA repairGO:0062819.9RAD51, BRCA1, BRCA2, ATM, KIF22
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.8HIC1, CHEK2, ATM, MLH1, BRCA1
11positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435179.8HIC1, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.7RAD51, BRCA2, MLH1
2identical protein bindingGO:0428029.6ESR1, RAD51, CHEK2, DRD2, FHIT
3protein bindingGO:0055157.5CHEK2, MLH1, ATM, FHIT, HIC1, RND2

Products for genes affiliated with Bilateral Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bilateral Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet