MCID: BLT006
MIFTS: 50

Bilateral Breast Cancer malady

Cancer diseases category

Summaries for Bilateral Breast Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and male breast cancer. An important gene associated with Bilateral Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are FOXM1 transcription factor network and Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. The compounds cycloheximide and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and ovary, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Bilateral Breast Cancer

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

bilateral breast cancer 8 44 60
bilateral breast carcinoma 8


External Ids:

Disease Ontology8 DOID:6741
NCIt39 C8287

Related Diseases for Bilateral Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7PGR, ESR1, ACP1, BRCA2, BRCA1
2male breast cancer30.8PGR, BRCA2, BRCA1, ESR1
3gynecomastia30.3BRCA2, BRCA1, PGR, ESR1
4prostate cancer30.3ATM, GSTP1, ACP1, CHEK2, FHIT
5endometrial carcinoma30.0MLH1, PGR, ESR1
6osteosarcoma30.0ESR1, CHEK2
7li-fraumeni syndrome30.0ESR1, PGR
8ductal carcinoma in situ30.0BRCA2, ESR1, BRCA1, PGR
9acute leukemia30.0ACP1, ATM, GSTP1, FHIT
10ataxia telangiectasia30.0CHEK2, BRCA1, RAD51, ATM, BRCA2, DRD2
11lung cancer30.0GSTP1, ATM, FHIT, CHEK2
12hepatocellular carcinoma30.0ACP1, HIC1, FHIT, BRCA2, GSTP1
13ovarian cancer30.0ESR1, MLH1, GSTP1, FHIT, BRCA2, BRCA1
14leukemia30.0BRCA1, GSTP1, ACP1, RAD51, CHEK2, ATM
15adenocarcinoma30.0FHIT, BRCA2, MLH1, BRCA1, CHEK2, HIC1
16breast disease10.5
17peutz-jeghers syndrome10.3
18prostatitis10.2
19non-hodgkin lymphoma10.1
20breast lymphoma10.1
21endometrial adenocarcinoma10.1
22burns10.0
23breast reconstruction10.0
24papillary serous adenocarcinoma10.0
25diffuse scleroderma10.0
26klinefelter's syndrome10.0
27breast osteosarcoma10.0
28sporadic breast cancer10.0
29synchronous bilateral breast carcinoma10.0
30sclerosing adenosis of breast10.0
31duodenitis10.0
32graves' disease10.0
33breast angiosarcoma10.0
34angiosarcoma10.0
35asthma10.0
36breast adenocarcinoma10.0
37breast carcinoma in situ10.0
38dermatomyositis10.0
39in situ carcinoma10.0
40intestinal obstruction10.0
41lymphoblastic leukemia10.0
42papillary adenocarcinoma10.0
43peritonitis10.0
44pituitary cancer10.0
45scleroderma10.0
46small intestine cancer10.0
47deficiency anemia10.0BRCA1
48breast-ovarian cancer, familial, 210.0BRCA2
49infertility10.0ESR1
50thyroid cancer10.0FHIT

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Clinical Features for Bilateral Breast Cancer

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Drugs & Therapeutics for Bilateral Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bilateral Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Search CenterWatch for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Bilateral Breast Cancer:

32
Breast, Prostate, Ovary, Testes, Pituitary, Lymph node, Small intestine, Lung, Cervix

Animal Models for Bilateral Breast Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bilateral Breast Cancer:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.2PGR, KIF22
2MP:00053719.8BRCA2, DRD2, HIC1, NBR1
3MP:00020069.6PGR, HIC1, CHEK2, MLH1, DRD2, FHIT
4MP:00107719.6BRCA1, BRCA2, FHIT, DRD2, HIC1, GSTP1
5MP:00053799.4BRCA1, BRCA2, DRD2, MLH1, ATM
6MP:00053909.1NBR1, ESR1, PGR, HIC1, DRD2, BRCA2
7MP:00053819.1BRCA1, BRCA2, FHIT, DRD2, MLH1, HIC1
8MP:00053978.9BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
9MP:00107688.5BRCA1, BRCA2, FHIT, DRD2, MLH1, ATM
10MP:00053878.5BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
11MP:00053848.5ATM, MLH1, DRD2, BRCA2, BRCA1, CHEK2

Publications for Bilateral Breast Cancer

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50PubMed
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Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. (23104382)
2013
2
One-staged silicone implant breast reconstruction following bilateral nipple-sparing prophylactic mastectomy in patients at high risk for breast cancer. (23860821)
2013
3
A novel, validated method to quantify breast cancer-related lymphedema (BCRL) following bilateral breast surgery. (24354105)
2013
4
Application of immediate breast reconstruction with silicon prosthetic implantation following bilateral mammary gland excision in treatment of young patients with early breast cancer. (23825759)
2013
5
A case of Muir-Torre syndrome with multiple cancers of bilateral eyelids and breast. (23730114)
2013
6
Increased risks of third primary cancers of non-breast origin among women with bilateral breast cancer. (22713658)
2012
7
Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience. (21193967)
2012
8
Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer. (22520019)
2012
9
Papillary-serous adenocarcinoma of the uterine cervix during tamoxifen therapy after bilateral breast cancer. (23155282)
2012
10
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (21989022)
2011
11
Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. (20665107)
2011
12
Bilateral breast cancer: a male patient. (21954546)
2011
13
Bilateral breast cancer in a survivor of acute lymphoblastic leukemia: a case report. (19472087)
2010
14
Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women. (19190627)
2009
15
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation. (19955943)
2009
16
Accuracy of the BRCAPRO model among women with bilateral breast cancer. (19127556)
2009
17
Identification of a de novo BRCA1 mutation in a woman with early onset bilateral breast cancer. (19629752)
2009
18
Unilateral and bilateral breast cancer in women surviving pediatric Hodgkin's disease. (18722264)
2008
19
Bilateral breast cancer in a male patient with hepatocellular carcinoma. A case report. (18727274)
2008
20
Co-occurrence of atypical endometriosis, subserous uterine leiomyomata, sactosalpinx, serous cystadenoma and bilateral hemorrhagic corpora lutea in a perimenopausal adipose patient taking tamoxifen (20 mg/day) for invasive lobular breast cancer. (18645252)
2008
21
Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group. (18250348)
2008
22
Incidental discovery of bilateral breast cancer in a 24-year-old man presenting with gynecomastia. (17522493)
2007
23
Survival after bilateral breast cancer: results from a population-based study. (17186359)
2007
24
Bilateral breast cancer: differential diagnosis using histological and biological parameters. (17673471)
2007
25
A case of metachronous bilateral breast cancer with bilateral radiation pneumonitis after breast-conserving therapy. (16929127)
2006
26
A comparison of bilateral breast cancers in BRCA carriers. (15941968)
2005
27
Breast-conserving therapy in patients with bilateral breast cancer: do today's treatment choices burn bridges for tomorrow? (15890578)
2005
28
Synchronous bilateral breast cancer in an elderly man. (15730469)
2005
29
Phenotypic similarities in bilateral breast cancer. (15111764)
2004
30
Bilateral breast cancer associated with diffuse scleroderma. (14659331)
2003
31
BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age. (11389159)
2001
32
Bilateral male breast cancer and prostate cancer: a case report. (10830988)
2000
33
Mammographic and ultrasonographic findings in bilateral breast cancer: a comparative study. (9569339)
1998
34
Early-stage bilateral breast cancer treated with breast-conserving surgery and definitive irradiation: the University of Pennsylvania experience. (9276360)
1997
35
Bilateral breast cancer: early detection with mammography. (7617856)
1995
36
Early adult body weight, body mass index, and premenopausal bilateral breast cancer: data from a case-control study. (7749135)
1995
37
Prognostic factors in bilateral breast cancer. (7870220)
1994
38
A linkage analysis of D17S74 (CMM86) in thirty-five families with premenopausal bilateral breast cancer. (8417809)
1993
39
Bilateral breast cancer: one disease or two? (1663803)
1991
40
Bilateral breast cancer. (2218824)
1990
41
Possible heterogeneity in the segregation pattern of breast cancer in families with bilateral breast cancer. (3402724)
1988
42
Primary bilateral breast cancer. (3025460)
1986
43
Bilateral familial breast cancer. (3026993)
1986
44
Age at first primary as a determinant of the incidence of bilateral breast cancer. Cumulative and relative risks in a population-based case-control study. (3965112)
1985
45
Survival in bilateral breast cancer. (3971312)
1985
46
Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol No. 4). XI. Bilateral breast cancer. (6498774)
1984
47
Bilateral breast cancer what about the other breast? (1012550)
1976
48
Bilateral breast cancer at the Johns Hopkins Hospital. A discussion of the dilemma of contralateral breast cancer. (5156944)
1971
49
Bilateral breast cancer. (5389668)
1969
50
CASE REPORTS FROM THE COMMITTEE ON CANCER; SIMULTANEOUS BILATERAL BREAST CANCER. (14302876)
1965

Genetic Variations for Bilateral Breast Cancer

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Expression for genes affiliated with Bilateral Breast Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

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Sources:
37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 29KEGG, 49PharmGKB, 4Cell Signaling Technology
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Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CHEK2, BRCA2
2
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10.2CHEK2, ATM
3
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10.2RAD51, BRCA2
4
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10.2ATM, BRCA1
5
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10.0BRCA1, ATM, CHEK2
610.0BRCA1, ATM, CHEK2
7
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10.0CHEK2, ATM, BRCA1
810.0BRCA1, ATM, CHEK2
9
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10.0BRCA1, BRCA2, ATM
10
Hide members
10.0RAD51, ATM, BRCA2
1110.0MLH1, ATM, PGR
1210.0MLH1, CHEK2, GSTP1
139.9BRCA1, ATM, HIC1
14
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9.9RAD51, CHEK2, ATM, BRCA1
159.9RAD51, CHEK2, ATM, BRCA1
16
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
17
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
18
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
19
Cell cycle Cell cycle (generic schema)
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9.9ESR1, PGR, CHEK2, BRCA1
209.8RAD51, MLH1, BRCA2, BRCA1
219.8GSTP1, RAD51, MLH1, BRCA2
229.7BRCA1, BRCA2, ATM, CHEK2, RAD51
23
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9.7BRCA1, BRCA2, MLH1, ATM, RAD51
24
Hide members
9.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
259.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
269.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
27
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.6RAD51, CHEK2, ATM, MLH1, BRCA2, BRCA1
28
Hide members
9.6BRCA1, BRCA2, MLH1, ATM, CHEK2, RAD51

Compounds for genes affiliated with Bilateral Breast Cancer

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5BRCA1, BRCA2
2ici 1643844410.5ESR1, PGR
3Ethynodiol Diacetate1110.5ESR1, PGR
4resveratrol44 59 11 2413.5BRCA2, PGR
5Allylestrenol1110.4ESR1, PGR
6adriamycin4410.4PGR, GSTP1, CHEK2
7Etonogestrel1110.4PGR, ESR1
8daidzein4410.4BRCA2, ESR1, BRCA1
9idoxifene4410.4ESR1, PGR
10droloxifene4410.4ESR1, PGR, GSTP1
11nomegestrol acetate4410.3GSTP1, ESR1, PGR
12lycopene44 2411.3BRCA1, BRCA2, GSTP1
13h2o24410.3RAD51, ACP1
14bpde4410.3GSTP1, BRCA1, ATM, CHEK2
154-hydroxytamoxifen4410.2ESR1, PGR, BRCA2, BRCA1
16o6-methylguanine4410.2GSTP1, RAD51, MLH1, BRCA2
17bleomycin44 1111.2ATM, GSTP1, BRCA2, BRCA1
18gemcitabine44 49 1112.2CHEK2, MLH1, BRCA1, RAD51
19caffeine44 49 28 2 11 2415.2BRCA1, RAD51, CHEK2, ATM
20sodium bisulfite4410.2MLH1, BRCA1, FHIT, GSTP1
21hydroxyurea44 49 1112.2BRCA1, BRCA2, ATM, RAD51, CHEK2
22platinum44 4911.2GSTP1, BRCA1, MLH1
23triphenylethylene4410.2PGR, ESR1
24indole-3-carbinol4410.1BRCA1, BRCA2, ESR1
25aphidicolin4410.1RAD51, BRCA1, FHIT, ATM, CHEK2
26thymidylate4410.1GSTP1, RAD51, BRCA1, MLH1
27mitomycin c4410.1RAD51, ATM, BRCA2, GSTP1, BRCA1
28neocarzinostatin4410.1ATM, CHEK2
29docetaxel44 49 59 1113.1GSTP1, PGR, ESR1, BRCA1, BRCA2
30methotrexate44 49 1112.1BRCA1, BRCA2, ESR1, GSTP1, PGR
31methylmethanesulfonate4410.0RAD51, BRCA2, BRCA1
32folate4410.0PGR, MLH1, BRCA2, BRCA1, GSTP1
335fluorouracil4410.0MLH1, PGR, ESR1, BRCA1, GSTP1
34cyclophosphamide44 49 1112.0GSTP1, PGR, ESR1, BRCA1
35polyacrylamide449.9MLH1, FHIT, BRCA2, BRCA1, RAD51, ATM
36steroid449.9ESR1, FHIT, BRCA2, BRCA1
37adenine44 11 2411.9RAD51, MLH1, BRCA1, ACP1
38camptothecin44 59 1111.8RAD51, ATM, CHEK2, MLH1, BRCA2, BRCA1
39progesterone44 59 28 11 2413.7ESR1, MLH1, PGR, BRCA1, BRCA2, FHIT
40topotecan44 1110.7GSTP1, BRCA1, ATM
415-aza-2deoxycytidine449.6ESR1, GSTP1, BRCA1, PGR, FHIT, HIC1
42paclitaxel44 49 1111.6GSTP1, PGR, MLH1, BRCA2, BRCA1, FHIT
43paraffin449.6BRCA2, GSTP1, ESR1, BRCA1, PGR, ATM
44alanine449.6PGR, MLH1, CHEK2, GSTP1, BRCA1, RAD51
45etoposide44 49 59 1112.5RAD51, MLH1, ATM, CHEK2, BRCA2, BRCA1
46genistein44 28 59 2 11 2414.5GSTP1, ESR1, CHEK2, ACP1, ATM, BRCA2
47doxorubicin44 49 1111.5BRCA1, MLH1, ATM, PGR, ACP1, GSTP1
48vegf449.4DRD2, RAD51, GSTP1, ACP1, BRCA1, PGR
49retinoic acid44 2410.3ESR1, GSTP1, PGR, CHEK2, MLH1, BRCA2
50cisplatin44 49 59 1111.9BRCA2, GSTP1, BRCA1, FHIT, DRD2, MLH1

GO Terms for genes affiliated with Bilateral Breast Cancer

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16Gene Ontology
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Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4ESR1, RAD51, PGR, CHEK2, ATM, BRCA2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.3ATM, CHEK2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3reciprocal meiotic recombinationGO:00713110.1RAD51, ATM, MLH1
4double-strand break repair via homologous recombinationGO:00072410.1RAD51, ATM, BRCA2, BRCA1
5replicative senescenceGO:09039910.1CHEK2, ATM
6regulation of stress-activated MAPK cascadeGO:03287210.0GSTP1, NBR1
7response to DNA damage stimulusGO:00697410.0BRCA1, ATM, CHEK2, RAD51
8double-strand break repairGO:00630210.0BRCA1, BRCA2, ATM, CHEK2, RAD51
9DNA repairGO:0062819.9BRCA1, BRCA2, ATM, KIF22, RAD51
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.8HIC1, CHEK2, ATM, MLH1, BRCA1
11positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435179.8HIC1, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.7BRCA2, MLH1, RAD51
2identical protein bindingGO:0428029.6ESR1, RAD51, CHEK2, DRD2, FHIT
3protein bindingGO:0055157.5GSTP1, BRCA1, BRCA2, FHIT, DRD2, MLH1

Products for genes affiliated with Bilateral Breast Cancer

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  • Antibodies
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Sources for Bilateral Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet