MCID: BLT006
MIFTS: 50

Bilateral Breast Cancer malady

Cancer diseases category

Summaries for Bilateral Breast Cancer

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and male breast cancer. An important gene associated with Bilateral Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are FOXM1 transcription factor network and Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. The compounds cycloheximide and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testes, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Bilateral Breast Cancer

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

bilateral breast cancer 8 44 60
bilateral breast carcinoma 8


External Ids:

Disease Ontology8 DOID:6741
NCIt39 C8287

Related Diseases for Bilateral Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7PGR, ESR1, ACP1, BRCA2, BRCA1
2male breast cancer30.8PGR, BRCA2, BRCA1, ESR1
3gynecomastia30.3BRCA2, BRCA1, PGR, ESR1
4prostate cancer30.3ATM, GSTP1, ACP1, CHEK2, FHIT
5endometrial carcinoma30.0MLH1, PGR, ESR1
6osteosarcoma30.0ESR1, CHEK2
7li-fraumeni syndrome30.0ESR1, PGR
8ductal carcinoma in situ30.0BRCA2, ESR1, BRCA1, PGR
9acute leukemia30.0ACP1, ATM, GSTP1, FHIT
10ataxia telangiectasia30.0CHEK2, BRCA1, RAD51, ATM, BRCA2, DRD2
11lung cancer30.0GSTP1, ATM, FHIT, CHEK2
12hepatocellular carcinoma30.0ACP1, HIC1, FHIT, BRCA2, GSTP1
13ovarian cancer30.0ESR1, MLH1, GSTP1, FHIT, BRCA2, BRCA1
14leukemia30.0BRCA1, GSTP1, ACP1, RAD51, CHEK2, ATM
15adenocarcinoma30.0FHIT, BRCA2, MLH1, BRCA1, CHEK2, HIC1
16breast disease10.5
17peutz-jeghers syndrome10.3
18prostatitis10.2
19non-hodgkin lymphoma10.1
20breast lymphoma10.1
21endometrial adenocarcinoma10.1
22burns10.0
23breast reconstruction10.0
24papillary serous adenocarcinoma10.0
25diffuse scleroderma10.0
26klinefelter's syndrome10.0
27breast osteosarcoma10.0
28sporadic breast cancer10.0
29synchronous bilateral breast carcinoma10.0
30sclerosing adenosis of breast10.0
31duodenitis10.0
32graves' disease10.0
33breast angiosarcoma10.0
34angiosarcoma10.0
35asthma10.0
36breast adenocarcinoma10.0
37breast carcinoma in situ10.0
38dermatomyositis10.0
39in situ carcinoma10.0
40intestinal obstruction10.0
41lymphoblastic leukemia10.0
42papillary adenocarcinoma10.0
43peritonitis10.0
44pituitary cancer10.0
45scleroderma10.0
46small intestine cancer10.0
47deficiency anemia10.0BRCA1
48breast-ovarian cancer, familial, 210.0BRCA2
49infertility10.0ESR1
50thyroid cancer10.0FHIT

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Clinical Features for Bilateral Breast Cancer

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Drugs & Therapeutics for Bilateral Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bilateral Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Search CenterWatch for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Bilateral Breast Cancer:

32
Breast, Prostate, Testes, Ovary, Pituitary, Lymph node, Lung, Small intestine, Cervix

Animal Models for Bilateral Breast Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bilateral Breast Cancer:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.2PGR, KIF22
2MP:00053719.8BRCA2, DRD2, HIC1, NBR1
3MP:00020069.6PGR, HIC1, CHEK2, MLH1, DRD2, FHIT
4MP:00107719.6BRCA1, BRCA2, FHIT, DRD2, HIC1, GSTP1
5MP:00053799.4BRCA1, BRCA2, DRD2, MLH1, ATM
6MP:00053909.1NBR1, ESR1, PGR, HIC1, DRD2, BRCA2
7MP:00053819.1BRCA1, BRCA2, FHIT, DRD2, MLH1, HIC1
8MP:00053978.9BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
9MP:00107688.5BRCA1, BRCA2, FHIT, DRD2, MLH1, ATM
10MP:00053878.5BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
11MP:00053848.5ATM, MLH1, DRD2, BRCA2, BRCA1, CHEK2

Publications for Bilateral Breast Cancer

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50PubMed
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Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Bilateral chylothorax following left supraclavicular lymph node dissection for breast cancer: one case report and treatment. (24417875)
2014
2
One-staged silicone implant breast reconstruction following bilateral nipple-sparing prophylactic mastectomy in patients at high-risk for breast cancer. (23322096)
2013
3
Histo-biological comparative analysis of bilateral breast cancer. (24062258)
2013
4
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer. (24382440)
2013
5
Male breast cancer presenting with bilateral pleural effusion. (23378963)
2013
6
Dermatomyositis as paraneoplastic syndrome of peritoneal and ovarian relapse after long-term complete remission in patient with metastatic bilateral breast cancer. (22816241)
2012
7
Less scarring or more symmetry? Reconstruction following metachronous bilateral breast cancer. (22560454)
2012
8
Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand. (22799341)
2012
9
PALB2 mutations in German and Russian patients with bilateral breast cancer. (21165770)
2011
10
Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. (21093260)
2011
11
Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer. (19372713)
2009
12
An unusual case of advanced bilateral male breast cancer. (18854654)
2008
13
Bilateral male breast cancer with male potential hypogonadism. (17543123)
2007
14
Searching for susceptibility alleles: emphasis on bilateral breast cancer. (17444500)
2007
15
Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. (16544057)
2006
16
Bilateral breast cancer. Incidence, diagnosis and histological patterns. (15900371)
2005
17
Bilateral breast-conserving therapy for bilateral breast cancer: results and consideration of radiation technique. (15858445)
2005
18
Association of common ATM polymorphism with bilateral breast cancer. (15756685)
2005
19
A case of bilateral breast cancer and Graves' disease. (15656338)
2004
20
Synchronous, bilateral breast cancer: prognostic value and incidence. (14659335)
2003
21
Synchronous bilateral breast cancer with Paget's disease and invasive ductal carcinoma: report of a case. (12924421)
2003
22
High and differential expression of HER-2/neu extracellular domain in bilateral ductal fluids from women with unilateral invasive breast cancer. (12576424)
2003
23
The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. (12099647)
2002
24
Primary breast lymphoma, contralateral breast cancer, and bilateral Brenner tumors of the ovary. (12423812)
2002
25
Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer. (11556836)
2001
26
Protein accumulation and gene mutation of p53 in bilateral breast cancer. South-East Sweden Breast Cancer Group. (11321662)
2001
27
Identification of Rad51 alteration in patients with bilateral breast cancer. (10807537)
2000
28
Intention to undergo prophylactic bilateral mastectomy in women at increased risk of developing hereditary breast cancer. (10829045)
2000
29
Feasibility of breast conservation therapy in metachronous or synchronous bilateral breast cancer. (10030422)
1999
30
Diet and premenopausal bilateral breast cancer: a case-control study. (9065608)
1997
31
Clinical epidemiology of bilateral breast cancer. (8252478)
1993
32
Bilateral breast cancer. (8239195)
1993
33
Oral contraceptives and premenopausal bilateral breast cancer: a case-control study. (1391133)
1992
34
Genetic epidemiology of bilateral breast cancer: a linkage analysis using the affected-pedigree-member method. (2328913)
1990
35
A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. II. Linkage analysis. (2766568)
1989
36
Bilateral breast cancer. (2545121)
1989
37
Estrogen receptors in bilateral breast cancer. (3383109)
1988
38
Prognosis in bilateral breast cancer. Effects of time interval between first and second primary tumours. (3166909)
1988
39
Primary synchronous bilateral breast cancer: epidemiological approach. (3228594)
1988
40
Tumor-associated antigens in bilateral breast cancer. (2437406)
1987
41
Bilateral breast cancer: the frequency of undiagnosed cancers. (3017110)
1986
42
Bilaterality in familial breast cancer patients. (2992756)
1985
43
Incidence of lobular carcinoma in bilateral breast cancer. (6293326)
1982
44
Bilateral breast cancer: radiation therapy results and technical considerations. (7275710)
1981
45
Factors influencing survival in bilateral breast cancer. (7253654)
1981
46
Characteristics of familial breast cancer in Sweden: absence of relation to age and unilateral versus bilateral disease. (7284970)
1981
47
Bilateral breast cancer. (356301)
1978
48
Simultaneous bilateral breast cancer. (852934)
1977
49
Bilateral breast cancer: biopsy of the opposite breast. (907998)
1977
50
Bilateral breast cancer. (18143507)
1949

Genetic Variations for Bilateral Breast Cancer

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Expression for genes affiliated with Bilateral Breast Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

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Sources:
37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 29KEGG, 49PharmGKB, 4Cell Signaling Technology
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Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CHEK2, BRCA2
2
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10.2CHEK2, ATM
3
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10.2RAD51, BRCA2
4
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10.2ATM, BRCA1
5
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10.0BRCA1, ATM, CHEK2
610.0BRCA1, ATM, CHEK2
7
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10.0CHEK2, ATM, BRCA1
810.0BRCA1, ATM, CHEK2
9
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10.0BRCA1, BRCA2, ATM
10
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10.0RAD51, ATM, BRCA2
1110.0MLH1, ATM, PGR
1210.0MLH1, CHEK2, GSTP1
139.9BRCA1, ATM, HIC1
14
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9.9RAD51, CHEK2, ATM, BRCA1
159.9RAD51, CHEK2, ATM, BRCA1
16
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9.9BRCA1, BRCA2, ATM, RAD51
17
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9.9BRCA1, BRCA2, ATM, RAD51
18
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
19
Cell cycle Cell cycle (generic schema)
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9.9ESR1, PGR, CHEK2, BRCA1
209.8RAD51, MLH1, BRCA2, BRCA1
219.8GSTP1, RAD51, MLH1, BRCA2
229.7BRCA1, BRCA2, ATM, CHEK2, RAD51
23
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9.7BRCA1, BRCA2, MLH1, ATM, RAD51
24
Hide members
9.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
259.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
269.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
27
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.6RAD51, CHEK2, ATM, MLH1, BRCA2, BRCA1
28
Hide members
9.6BRCA1, BRCA2, MLH1, ATM, CHEK2, RAD51

Compounds for genes affiliated with Bilateral Breast Cancer

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5BRCA1, BRCA2
2ici 1643844410.5ESR1, PGR
3Ethynodiol Diacetate1110.5ESR1, PGR
4resveratrol44 59 11 2413.5BRCA2, PGR
5Allylestrenol1110.4ESR1, PGR
6adriamycin4410.4PGR, GSTP1, CHEK2
7Etonogestrel1110.4PGR, ESR1
8daidzein4410.4BRCA2, ESR1, BRCA1
9idoxifene4410.4ESR1, PGR
10droloxifene4410.4ESR1, PGR, GSTP1
11nomegestrol acetate4410.3GSTP1, ESR1, PGR
12lycopene44 2411.3BRCA1, BRCA2, GSTP1
13h2o24410.3RAD51, ACP1
14bpde4410.3GSTP1, BRCA1, ATM, CHEK2
154-hydroxytamoxifen4410.2ESR1, PGR, BRCA2, BRCA1
16o6-methylguanine4410.2GSTP1, RAD51, MLH1, BRCA2
17bleomycin44 1111.2ATM, GSTP1, BRCA2, BRCA1
18gemcitabine44 49 1112.2CHEK2, MLH1, BRCA1, RAD51
19caffeine44 49 28 2 11 2415.2BRCA1, RAD51, CHEK2, ATM
20sodium bisulfite4410.2MLH1, BRCA1, FHIT, GSTP1
21hydroxyurea44 49 1112.2BRCA1, BRCA2, ATM, RAD51, CHEK2
22platinum44 4911.2GSTP1, BRCA1, MLH1
23triphenylethylene4410.2PGR, ESR1
24indole-3-carbinol4410.1BRCA1, BRCA2, ESR1
25aphidicolin4410.1RAD51, BRCA1, FHIT, ATM, CHEK2
26thymidylate4410.1GSTP1, RAD51, BRCA1, MLH1
27mitomycin c4410.1RAD51, ATM, BRCA2, GSTP1, BRCA1
28neocarzinostatin4410.1ATM, CHEK2
29docetaxel44 49 59 1113.1GSTP1, PGR, ESR1, BRCA1, BRCA2
30methotrexate44 49 1112.1BRCA1, BRCA2, ESR1, GSTP1, PGR
31methylmethanesulfonate4410.0RAD51, BRCA2, BRCA1
32folate4410.0PGR, MLH1, BRCA2, BRCA1, GSTP1
335fluorouracil4410.0MLH1, PGR, ESR1, BRCA1, GSTP1
34cyclophosphamide44 49 1112.0GSTP1, PGR, ESR1, BRCA1
35polyacrylamide449.9MLH1, FHIT, BRCA2, BRCA1, RAD51, ATM
36steroid449.9ESR1, FHIT, BRCA2, BRCA1
37adenine44 11 2411.9RAD51, MLH1, BRCA1, ACP1
38camptothecin44 59 1111.8RAD51, ATM, CHEK2, MLH1, BRCA2, BRCA1
39progesterone44 59 28 11 2413.7ESR1, MLH1, PGR, BRCA1, BRCA2, FHIT
40topotecan44 1110.7GSTP1, BRCA1, ATM
415-aza-2deoxycytidine449.6ESR1, GSTP1, BRCA1, PGR, FHIT, HIC1
42paclitaxel44 49 1111.6GSTP1, PGR, MLH1, BRCA2, BRCA1, FHIT
43paraffin449.6BRCA2, GSTP1, ESR1, BRCA1, PGR, ATM
44alanine449.6PGR, MLH1, CHEK2, GSTP1, BRCA1, RAD51
45etoposide44 49 59 1112.5RAD51, MLH1, ATM, CHEK2, BRCA2, BRCA1
46genistein44 28 59 2 11 2414.5GSTP1, ESR1, CHEK2, ACP1, ATM, BRCA2
47doxorubicin44 49 1111.5BRCA1, MLH1, ATM, PGR, ACP1, GSTP1
48vegf449.4DRD2, RAD51, GSTP1, ACP1, BRCA1, PGR
49retinoic acid44 2410.3ESR1, GSTP1, PGR, CHEK2, MLH1, BRCA2
50cisplatin44 49 59 1111.9BRCA2, GSTP1, BRCA1, FHIT, DRD2, MLH1

GO Terms for genes affiliated with Bilateral Breast Cancer

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16Gene Ontology
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Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4ESR1, RAD51, PGR, CHEK2, ATM, BRCA2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.3ATM, CHEK2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3reciprocal meiotic recombinationGO:00713110.1RAD51, ATM, MLH1
4double-strand break repair via homologous recombinationGO:00072410.1RAD51, ATM, BRCA2, BRCA1
5replicative senescenceGO:09039910.1CHEK2, ATM
6regulation of stress-activated MAPK cascadeGO:03287210.0GSTP1, NBR1
7response to DNA damage stimulusGO:00697410.0BRCA1, ATM, CHEK2, RAD51
8double-strand break repairGO:00630210.0BRCA1, BRCA2, ATM, CHEK2, RAD51
9DNA repairGO:0062819.9BRCA1, BRCA2, ATM, KIF22, RAD51
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.8HIC1, CHEK2, ATM, MLH1, BRCA1
11positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435179.8HIC1, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.7BRCA2, MLH1, RAD51
2identical protein bindingGO:0428029.6ESR1, RAD51, CHEK2, DRD2, FHIT
3protein bindingGO:0055157.5GSTP1, BRCA1, BRCA2, FHIT, DRD2, MLH1

Products for genes affiliated with Bilateral Breast Cancer

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  • Antibodies
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Sources for Bilateral Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet