Bilateral Breast Cancer malady

Disease Ontology: A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.⁶

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and synchronous bilateral breast carcinoma. An important gene associated with Bilateral Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are Pancreatic cancer and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds mitomycin c and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and pituitary, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

bilateral breast cancer 6 8 32 43 bilateral breast carcinoma 6

Diseases related to bilateral breast cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 338)

id	Related Disease	Score	Top Affiliating Genes
1	breast cancer	36.8	RAD51, CHEK2, ATM
2	synchronous bilateral breast carcinoma	33.9	BRCA2, PGR
3	prostate cancer	29.0	GSTP1, PTEN, KLK3
4	ataxia telangiectasia	27.7	PIK3CA, BRCA1, BRCA2, RAD51, CHEK2, ATM
5	angiosarcoma	27.6	BRCA1, CDKN3, ESR1, ERBB2, TP53, PTEN
6	ataxia	26.3	PIK3CA, BRCA1, BRCA2, RAD51, CHEK2, ATM
7	breast carcinoma	25.6	PIK3CA, BRCA1, BRCA2, RAD51, CHEK2, ATM
8	carcinoma	24.5	PIK3CA, KIF22, NBR1, BRCA1, BRCA2, RAD51
9	prostatitis	21.0	PIK3CA, BRCA1, BRCA2, RAD51, CHEK2, ATM
10	lynch syndrome	13.7	BRCA1, BRCA2
11	brca1 and brca2 hereditary breast and ovarian cancer	13.7	BRCA1, BRCA2
12	vulvar syringoma	13.7	ESR1, PGR
13	cribriform carcinoma	13.6	ESR1, PGR
14	catamenial pneumothorax	13.6	ESR1, PGR
15	progesterone resistance	13.6	ESR1, PGR
16	gender identity disorder	13.5	ESR1, PGR
17	cellular leiomyoma	13.4	ESR1, PGR
18	trigonitis	13.4	CDKN3, ESR1, PGR
19	breast cancer, somatic	13.4	PIK3CA, BRCA1, ATM
20	bubonic plague	13.4	CDKN3, ACP1
21	li-fraumeni-like syndrome	13.3	BRCA2, TP53
22	comedo carcinoma	13.3	ESR1, ERBB2
23	bannayan-riley-ruvalcaba syndrome	13.3	CDKN3, PTEN
24	apocrine adenosis of breast	13.3	ERBB2, PGR
25	fallopian tube carcinoma	13.3	BRCA1, BRCA2, ERBB2
26	tic disorder	13.3	DRD2, ACP1
27	uterine adnexa cancer	13.2	MLH1, ESR1
28	glassy cell carcinoma of the cervix	13.2	ESR1, ERBB2, PGR
29	progesterone-receptor positive breast cancer	13.2	ESR1, ERBB2, PGR
30	mammary paget's disease	13.2	ESR1, ERBB2, PGR
31	progesterone-receptor negative breast cancer	13.2	ESR1, ERBB2, PGR
32	microglandular adenosis	13.2	ESR1, ERBB2, PGR
33	ovarian cancer	13.2	BRCA1, ERBB2, PGR
34	mutagen sensitivity	13.2	BRCA1, BRCA2, TP53
35	t-cell prolymphocytic leukemia	13.2	CHEK2, ATM, TP53
36	hereditary pancreatitis	13.2	BRCA1, BRCA2, RAD51, ATM, GSTP1
37	serous cystadenocarcinoma	13.1	ESR1, TP53, PGR
38	brain cancer	13.1	BRCA2, RAD51, PTEN
39	balanitis	13.1	PIK3CA, ATM, ESR1, PGR
40	malignant mixed mullerian tumor	13.1	ESR1, PGR
41	tubular adenocarcinoma	13.1	ESR1, ERBB2, PGR
42	pulmonary neuroendocrine tumor	13.1	ESR1, TP53, PGR
43	prolymphocytic leukemia	13.1	CHEK2, ATM, TP53
44	breast fibroadenoma	13.1	ESR1, ERBB2, PGR
45	hereditary breast ovarian cancer	13.1	BRCA1, BRCA2, CHEK2, TP53
46	rectum sarcomatoid carcinoma	13.1	ESR1, ERBB2, PGR
47	leopard syndrome	13.1	PIK3CA, CDKN3, ACP1
48	papillary serous adenocarcinoma	13.1	ERBB2, PGR
49	meningioma	13.0	ESR1, PGR
50	ovarian cancer, somatic	13.0	PIK3CA, ERBB2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to bilateral breast cancer:

²²

MGI Mouse Phenotypes related to bilateral breast cancer:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	BRCA1, BRCA2
2	hematopoietic system phenotype	MP:0005397	9.5	FHIT, ATM, CHEK2, BRCA2, BRCA1, NBR1
3	limbs/digits/tail phenotype	MP:0005371	9.2	DRD2, ERBB2, ESR1, BRCA2, BRCA1, NBR1
4	adipose tissue phenotype	MP:0005375	8.6	DRD2, TP53, ESR1, BRCA1, PIK3CA, PTEN
5	reproductive system phenotype	MP:0005389	8.5	PRL, DRD2, ERBB2, MLH1, BRCA2, BRCA1
6	behavior/neurological phenotype	MP:0005386	8.4	PGR, PRL, PTEN, DRD2, ATM, BRCA2
7	embryogenesis phenotype	MP:0005380	8.2	PGR, PRL, HIC1, ERBB2, ATM, RAD51
8	skeleton phenotype	MP:0005390	8.0	PGR, HIC1, PTEN, DRD2, TP53, ERBB2
9	immune system phenotype	MP:0005387	7.9	PRL, HIC1, ACP1, DRD2, TP53, FHIT
10	digestive/alimentary phenotype	MP:0005381	7.8	HIC1, PTEN, DRD2, TP53, ERBB2, ESR1
11	muscle phenotype	MP:0005369	7.6	PGR, PTEN, DRD2, TP53, ERBB2, ESR1
12	mortality/aging	MP:0010768	7.2	FHIT, TP53, DRD2, PTEN, HIC1, CDH13
13	integument phenotype	MP:0010771	6.9	PGR, PRL, HIC1, PTEN, DRD2, TP53
14	growth/size phenotype	MP:0005378	6.7	HIC1, ACP1, PTEN, DRD2, TP53, ERBB2
15	cellular phenotype	MP:0005384	6.5	ESR1, ERBB2, TP53, DRD2, PTEN, ACP1
16	homeostasis/metabolism phenotype	MP:0005376	6.2	ERBB2, TP53, DRD2, PTEN, PRL, PGR
17	tumorigenesis	MP:0002006	5.6	PIK3CA, PGR, PRL, HIC1, PTEN, DRD2

Articles related to bilateral breast cancer:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (21989022)	Garcia-Casado Z.... Lopez-Guerrero J.A.	2011	BRCA1, NBR1, RND2
2	A novel de novo BRCA2 mutation of paternal origin ide ntified in a Spanish woman with early onset bilateral breast cancer. (19649703)	Diez O.... BalmaA+a J.	2010	BRCA1, BRCA2
3	Characterization of BRCA1 and BRCA2 deleterious mutat ions and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study. (20104584)	Borg A.... Bernstein J.L.	2010	BRCA1, BRCA2
4	Accuracy of the BRCAPRO model among women with bilateral breast cancer. (19127556)	Ready K.J.... Arun B.	2009	BRCA1, BRCA2
5	Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls. (19124502)	Fletcher O.... Peto J.	2009	CHEK2
6	Cutaneous angiosarcoma after breast conserving treatm ent for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case repo rt and review of the literature. (19736894)	Williams S.B.... Reed M.	2009	BRCA1
7	Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer. (19372713)	Skasko E.... PieA8kowski T.	2009	CHEK2, BRCA1, BRCA2
8	Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (19153073)	Flanagan J.M.... Petronis A.	2009	GSTP1, ATM, ESR1
9	Identification of a de novo BRCA1 mutation in a woman with early onset bilateral breast cancer. (19629752)	Edwards E.... Eccles D.	2009	BRCA1
10	A novel mutation of the PTEN gene in a Japanese patie nt with Cowden syndrome and bilateral breast cancer. (18558293)	Tate G.... Mitsuya T.	2008	PTEN, PIK3CA, ACP1
11	Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia. (17333477)	Sokolenko A.P.... Imyanitov E.N.	2007	CHEK2, BRCA1, BRCA2
12	Bilateral breast cancer: differential diagnosis using histological and biological parameters. (17673471)	Gong S.J.... Chung H.C.	2007	ERBB2, PGR
13	A comparison of bilateral breast cancers in BRCA carriers. (15941968)	Weitzel J.N.... Narod S.A.	2005	ESR1
14	Association of common ATM polymorphism with bilateral breast cancer. (15756685)	Heikkinen K.... Winqvist R.	2005	ATM
15	BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients. (15319244)	Rogozinska-Szczepka J.... Wojciechowska-L/acka A.	2004	BRCA1, BRCA2
16	ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer. (14562025)	Bernstein J.L.... Haile R.W.	2003	ATM
17	BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age. (11389159)	Bergthorsson J.T.... Niebuhr E.	2001	BRCA1, BRCA2
18	Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male. (11434671)	Forloni F.... Beck-Peccoz P.	2001	PRL
19	Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer. (11556836)	Steinmann D.... Dork T.	2001	BRCA1, BRCA2
20	A male case of primary bilateral breast cancers during estrogen therapy for prostate cancer (11766369)	Emoto A.... Wada M.	2001	KLK3
21	Loss of heterozygosity in bilateral breast cancer. (11200774)	Kollias J.... Brook J.D.	2000	TP53, FHIT
22	Identification of Rad51 alteration in patients with bilateral breast cancer. (10807537)	Kato M.... Miki Y.	2000	RAD51
23	BRCA1 and BRCA2 founder mutations in patients with bilateral breast cancer. (10573018)	Gershoni-Baruch R.... ROBINSON E.	1999	BRCA1, BRCA2
24	Clonal analysis of bilateral breast cancer. (9816225)	Shibata A.... Ross R.K.	1996	TP53
25	Estrogen and progesterone receptor content in bilateral breast cancer. (7651928)	BrankoviA8-MagiA8 M.... SpuziA8 I.	1995	PGR
26	Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer. (8221639)	Cortessis V.... Haile R.W.	1993	DRD2
27	Absence of p53 germ-line mutations in bilateral breast cancer patients. (1587536)	Lidereau R.... Soussi T.	1992	TP53
28	Bilateral breast cancer: one disease or two? (1663803)	Dawson P.J.... Wolman S.R.	1991	ESR1

Genes related to bilateral breast cancer according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	CHEK2	checkpoint kinase 2	11.0	Publications
2	BRCA2	breast cancer 2, early onset	11.0	Publications
3	BRCA1	breast cancer 1, early onset	11.0	Publications
4	RAD51	RAD51 homolog (S. cerevisiae)	11.0	Publications
5	ATM	ataxia telangiectasia mutated	11.0	Publications
6	ESR1	estrogen receptor 1	11.0	Publications
7	PGR	progesterone receptor	11.0	Publications
8	FHIT	fragile histidine triad	11.0	Publications
9	RPL21P4	ribosomal protein L21 pseudogene 4	11.0	Publications
10	BRCA1P1	BRCA1 pseudogene 1	11.0	Publications
11	TMEM106A	transmembrane protein 106A	11.0	Publications
12	NBR2	neighbor of BRCA1 gene 2 (non-protein coding)	11.0	Publications
13	RND2	Rho family GTPase 2	11.0	Publications
14	HIC1	hypermethylated in cancer 1	11.0	Publications
15	KIF22	kinesin family member 22	11.0
16	NBR1	neighbor of BRCA1 gene 1	11.0	Publications
17	ACP1	acid phosphatase 1, soluble	11.0	Publications
18	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
19	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications
20	DRD2	dopamine receptor D2	11.0	Publications
21	PTEN	phosphatase and tensin homolog	11.0	Publications
22	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
23	GSTP1	glutathione S-transferase pi 1	11.0	Publications
24	PRL	prolactin	11.0	Publications
25	TP53	tumor protein p53	11.0	Publications
26	CDH13	cadherin 13, H-cadherin (heart)	11.0	Publications
27	KLK3	kallikrein-related peptidase 3	11.0	Publications
28	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications

Pathways related to bilateral breast cancer according to GeneDecks:

(show all 36)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.7	BRCA2
2	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.5	ATM, CHEK2
3	G2/M DNA damage checkpoint38	10.2	CHEK2, ATM
4	Fanconis Anaemia Pathway36	10.2	ATM, RAD51, BRCA2, BRCA1
5	Development VEGF signaling and activation10	10.0	PIK3CA
6	DNA Damage Induced 14-3-3Sigma Signaling36	9.9	TP53, ATM, BRCA1
7	Cell cycle Role of 14-3-3 proteins in cell cycle regulation10	9.9	TP53, ATM, CHEK2
8	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation41	9.9	CHEK2, ATM, TP53
9	DNA damage_DNA-damage-induced responses41	9.9	TP53, ATM, CHEK2, BRCA1
10	DNA damage DNA-damage-induced responses10	9.9	TP53, ATM, CHEK2, BRCA1
11	DNA Damage3	9.9	TP53, CHEK2, BRCA2, BRCA1
12	GADD45 Pathway36	9.9	BRCA1, ATM, TP53
13	Development_EGFR signaling via PIP341	9.9	PTEN, ERBB2
14	Busulfan Pathway, Pharmacodynamics34	9.8	GSTP1, MLH1, CHEK2
15	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.8	BRCA1, CHEK2, ATM, TP53
16	Chks in Checkpoint Regulation36	9.8	TP53, ATM, CHEK2, BRCA1
17	Development_VEGF signaling and activation41	9.8	PIK3CA, BRCA1, ESR1
18	G2-M Phase Transition36	9.8	CHEK2, ATM, TP53
19	ATM Pathway36	9.7	TP53, ATM, CHEK2, RAD51, BRCA1
20	p53 signaling pathway20	9.6	CHEK2, ATM, TP53, PTEN
21	BRCA1 Pathway36	9.6	TP53, ATM, CHEK2, RAD51, BRCA2, BRCA1
22	DNA Repair Mechanisms36	9.6	TP53, ATM, CHEK2, RAD51, BRCA2, BRCA1
23	p53 Signaling36	9.5	BRCA1, CHEK2, ATM, TP53, PTEN
24	Development EGFR signaling via PIP310	9.5	PTEN, ERBB2, PIK3CA
25	Small cell lung cancer20	9.3	PIK3CA, FHIT, TP53, PTEN
26	DNA damage Role of Brca1 and Brca2 in DNA repair10	9.3	BRCA1, TP53, BRCA2, RAD51, CHEK2, ATM
27	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.3	TP53, MLH1, ATM, CHEK2, RAD51, BRCA2
28	p53 Mediated Apoptosis36	9.3	PTEN, TP53, ATM, CHEK2
29	Molecular Mechanisms of Cancer36	9.3	PTEN, TP53, ATM, CHEK2, BRCA1
30	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.2	PIK3CA, ERBB2, TP53
31	Non-small cell lung cancer20	9.2	TP53, ERBB2, FHIT, PIK3CA
32	Signal transduction PTEN pathway10	8.9	PIK3CA, TP53, PTEN
33	Cell Cycle / Checkpoint Control3	8.9	TP53, GSTP1, MLH1, ATM, CHEK2, RAD51
34	Endometrial cancer20	8.8	PTEN, TP53, ERBB2, MLH1, PIK3CA
35	Pathways in cancer20	8.4	PTEN, TP53, ERBB2, GSTP1, RAD51, BRCA2
36	Prostate cancer20	7.9	KLK3, PTEN, TP53, ERBB2, GSTP1, PIK3CA

Compounds related to bilateral breast cancer according to GeneDecks:

(show top 50)    (show all 149)

id	Compound	Score	Top Affiliating Genes
1	mitomycin c32	10.2	RAD51, BRCA2, BRCA1, ATM
2	h2o232	10.1	BRCA2, RAD51, CDKN3, BRCA1
3	rapamycin32 42	11.1	CHEK2, ACP1
4	vincristine32 34 9 9	12.9	KLK3
5	4-hydroxytamoxifen32	9.7	ERBB2, BRCA2, BRCA1
6	sodium bisulfite32	9.6	MLH1, FHIT, GSTP1, BRCA1
7	ly29400232	9.6	ERBB2, PIK3CA, CDKN3
8	aphidicolin32	9.6	BRCA1, TP53, RAD51, FHIT, ATM, CHEK2
9	hydroxyurea32 9 9	11.5	CHEK2, TP53, ATM, RAD51, BRCA1, BRCA2
10	bpde32	9.5	TP53, BRCA1, CHEK2, GSTP1, ATM
11	agar32	9.3	ERBB2, PGR, BRCA1, PIK3CA, FHIT
12	o6-methylguanine32	9.3	MLH1, RAD51, GSTP1, TP53, BRCA2
13	toremifene32 9 9	11.3	ESR1, PRL, PGR, ERBB2
14	lycopene32 18	10.1	GSTP1, KLK3
15	bleomycin32 9 9	11.1	BRCA1, BRCA2, ATM, GSTP1, CDKN3, TP53
16	crcs32	9.1	TP53, PTEN, PIK3CA, MLH1, FHIT
17	leuprolide acetate32	9.1	ESR1, PGR, KLK3, PRL
18	megestrol acetate32	9.0	PGR, KLK3, ERBB2, ESR1
19	topotecan32 9 9	11.0	TP53, BRCA1, ERBB2, GSTP1, ATM
20	trastuzumab32 34 9 9	11.9	ERBB2, ESR1, PTEN, PIK3CA, CDKN3, PGR
21	oxaliplatin32 34 9 9	11.8	ERBB2, MLH1, TP53, GSTP1, BRCA1
22	resveratrol32 9 18 9	11.8	ESR1, ERBB2, TP53, PGR, BRCA2, PIK3CA
23	adriamycin32	8.8	BRCA1, BRCA2, CHEK2, ERBB2, TP53, PGR
24	gemcitabine32 34 9 9	11.7	PTEN, TP53, ERBB2, MLH1, CHEK2, RAD51
25	indole-3-carbinol32	8.7	BRCA1, ESR1, KLK3, PTEN, TP53, BRCA2
26	thymidylate32	8.7	GSTP1, BRCA1, RAD51, ERBB2, MLH1, TP53
27	wortmannin32 42	9.5	CHEK2, ACP1, ERBB2, PIK3CA, RAD51, ATM
28	folate32	8.5	BRCA1, MLH1, BRCA2, PGR, ERBB2, GSTP1
29	taxane32	8.3	PTEN, TP53, PGR, KLK3, ESR1, ERBB2
30	gefitinib32 34 9 9	11.2	KLK3, PIK3CA, CDKN3, ESR1, ERBB2, PTEN
31	carboplatin32 34 9 9	11.2	TP53, ERBB2, MLH1, KLK3, BRCA1
32	tamoxifen32 34 9 9	11.0	BRCA2, TP53, PGR, PRL, PTEN, ERBB2
33	docetaxel32 34 9 9	11.0	BRCA1, BRCA2, GSTP1, ESR1, ERBB2, KLK3
34	5fluorouracil32	7.9	BRCA1, MLH1, GSTP1, ERBB2, TP53, PTEN
35	alanine32	7.9	PGR, ACP1, PTEN, ERBB2, MLH1, CHEK2
36	5-aza-2deoxycytidine32	7.8	FHIT, MLH1, CDH13, ESR1, TP53, PTEN
37	camptothecin32 42 9 9	10.8	MLH1, CDKN3, ATM, RAD51, BRCA2, CHEK2
38	genistein32 9 18 9	10.8	CDKN3, GSTP1, PGR, ACP1, PTEN, ERBB2
39	cycloheximide32	7.3	PGR, ACP1, KLK3, TP53, BRCA2, ERBB2
40	steroid32	7.2	BRCA1, BRCA2, MLH1, FHIT, PIK3CA, PGR
41	testosterone32 9 18 9	10.0	ERBB2, BRCA1, PIK3CA, BRCA2, CDKN3, GSTP1
42	progesterone32 42 9 18 9	11.0	PGR, ERBB2, ESR1, FHIT, TP53, PTEN
43	retinoic acid32 42 18	8.8	ESR1, GSTP1, PIK3CA, BRCA1, BRCA2, CDH13
44	etoposide32 42 9 9	9.8	PTEN, TP53, ERBB2, GSTP1, MLH1, CDKN3
45	paclitaxel32 34 9 9	9.7	PIK3CA, BRCA1, BRCA2, RAD51, MLH1, FHIT
46	doxorubicin32 34 9 9	9.6	GSTP1, PIK3CA, BRCA1, CHEK2, PGR, ACP1
47	paraffin32	6.4	ESR1, GSTP1, FHIT, MLH1, CDH13, ATM
48	cisplatin32 34 9 9	9.4	DRD2, PTEN, ACP1, HIC1, TP53, PIK3CA
49	vegf32	6.1	PGR, BRCA1, RAD51, CDKN3, MLH1, GSTP1
50	estrogen32	5.5	ATM, PIK3CA, FHIT, BRCA1, BRCA2, MLH1

Cellular components related to bilateral breast cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:016605	9.0	RAD51, CHEK2, TP53, PTEN
2	nucleoplasm	GO:005654	8.9	TP53, ESR1, ATM, CHEK2, RAD51, BRCA2

Biological processes related to bilateral breast cancer according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	double-strand break repair via homologous recombination	GO:000724	10.1	ATM, RAD51, BRCA2, BRCA1
2	DNA damage response, signal transduction resulting in induction of apoptosis	GO:008630	10.0	HIC1, ATM, CHEK2, BRCA1
3	DNA damage induced protein phosphorylation	GO:006975	9.9	CHEK2, ATM
4	replicative senescence	GO:090399	9.8	CHEK2, ATM, TP53
5	neuron-neuron synaptic transmission	GO:007270	9.8	DRD2, PTEN
6	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.8	TP53, BRCA2, BRCA1
7	response to gamma radiation	GO:010332	9.7	BRCA2, CHEK2, TP53
8	DNA repair	GO:006281	9.6	ATM, RAD51, BRCA2, BRCA1, KIF22
9	double-strand break repair	GO:006302	9.4	BRCA1, BRCA2, RAD51, CHEK2, ATM, TP53
10	response to DNA damage stimulus	GO:006974	9.4	TP53, ATM, CHEK2, BRCA1
11	endothelial cell migration	GO:043542	9.2	PIK3CA, CDH13, PTEN

Molecular functions related to bilateral breast cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	9.1	BRCA1, ESR1, TP53, PTEN, PGR
2	protein binding	GO:005515	4.0	PIK3CA, ERBB2, TP53, DRD2, PTEN, RND2