MCID: BLT006
MIFTS: 48

Bilateral Breast Cancer malady

Cancer diseases category
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Summaries for Bilateral Breast Cancer

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Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and gynecomastia. An important gene associated with Bilateral Breast Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and FOXM1 transcription factor network. The compounds daidzein and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and small intestine, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Bilateral Breast Cancer

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt
See all sources

Bilateral Breast Cancer, Aliases & Descriptions:

Name: Bilateral Breast Cancer 8 44 62
 
Bilateral Breast Carcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:6741
NCIt39 C8287

Related Diseases for Bilateral Breast Cancer

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Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.8BRCA2, BRCA1, PGR
2gynecomastia30.4BRCA2, BRCA1, PGR
3ductal carcinoma in situ30.1PGR, BRCA2, BRCA1
4li-fraumeni syndrome30.1BRCA1, PGR, BRCA2
5prostate cancer29.6BRCA1, CHEK2, BRCA2, ATM, RAD51
6adenocarcinoma29.4BRCA2, BRCA1, PGR, CHEK2, RAD51
7ataxia telangiectasia29.3CHEK2, BRCA1, BRCA2, ATM, RAD51
8leukemia29.2RAD51, CHEK2, BRCA1, BRCA2, ATM
9synchronous bilateral breast carcinoma10.6
10cystadenoma10.4BRCA1
11breast-ovarian cancer, familial, 110.4BRCA2
12peutz-jeghers syndrome10.3
13prostatitis10.3
14brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
15fallopian tube cancer10.2BRCA1, BRCA2
16peritoneal carcinoma10.2BRCA1, BRCA2
17familial colorectal cancer10.2BRCA2, BRCA1
18dysgerminoma10.2BRCA1, BRCA2
19cowden disease10.2BRCA2, BRCA1
20lynch syndrome10.2BRCA2, BRCA1
21breast ductal carcinoma10.2PGR, BRCA1
22non-hodgkin lymphoma10.1
23endometrial adenocarcinoma10.1
24acute lymphoblastic leukemia10.1
25asthma10.1
26burns10.1
27gastric cancer10.1
28hepatocellular carcinoma10.1
29papillary serous adenocarcinoma10.1
30klinefelter's syndrome10.1
31diffuse scleroderma10.1
32graves' disease10.1
33sporadic breast cancer10.1
34duodenitis10.1
35crest syndrome10.1
36angiosarcoma10.1
37dermatomyositis10.1
38lymphoblastic leukemia10.1
39osteosarcoma10.1
40peritonitis10.1
41scleroderma10.1
42kindler syndrome10.1
43malignant mixed mullerian tumor10.1
44ataxia10.1
45paraneoplastic syndromes10.1
46male breast cancer10.0BRCA2, BRCA1, PGR
47papillary carcinoma10.0PGR, BRCA2
48werner syndrome10.0ATM, BRCA1
49aplastic anemia10.0BRCA1, BRCA2, RAD51
50endometrial carcinoma10.0BRCA1, BRCA2, PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Symptoms for Bilateral Breast Cancer

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Drugs & Therapeutics for Bilateral Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

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Anatomical Context for Bilateral Breast Cancer

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MalaCards organs/tissues related to Bilateral Breast Cancer:

32
Breast, Prostate, Small intestine, Lung, Ovary, Testes, Cervix, Pituitary

Animal Models for Bilateral Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Bilateral Breast Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0PGR, BRCA2, BRCA1
2MP:00053798.1PGR, BRCA2, ATM, BRCA1
3MP:00020067.9ATM, BRCA2, BRCA1, CHEK2, PGR
4MP:00053897.9ATM, PGR, BRCA2, BRCA1
5MP:00053977.8ATM, BRCA2, BRCA1, PGR, CHEK2
6MP:00053877.7ATM, BRCA2, BRCA1, PGR, CHEK2
7MP:00053807.7PGR, BRCA2, ATM, RAD51, BRCA1
8MP:00053847.3CHEK2, RAD51, PGR, BRCA1, BRCA2, ATM
9MP:00107687.2CHEK2, RAD51, PGR, BRCA1, BRCA2, ATM

Publications for Bilateral Breast Cancer

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Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer. (24498881)
2014
2
Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. (25007962)
2014
3
Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. (25112434)
2014
4
Synchronous bilateral breast cancer in a male. (24319497)
2013
5
Histo-biological comparative analysis of bilateral breast cancer. (24062258)
2013
6
The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. (23296702)
2013
7
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. (23104382)
2013
8
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer. (24382440)
2013
9
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (21989022)
2011
10
Bilateral breast cancer in a survivor of acute lymphoblastic leukemia: a case report. (19472087)
2010
11
A novel de novo BRCA2 mutation of paternal origin identified in a Spanish woman with early onset bilateral breast cancer. (19649703)
2010
12
Cumulative survival in early-onset unilateral and bilateral breast cancer: an analysis of 1907 Taiwanese women. (19190627)
2009
13
Prognosis of synchronous bilateral breast cancer. (19283743)
2009
14
Synchronous bilateral breast cancer in a male patient following hormone therapy for prostate cancer. (19593618)
2009
15
Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study. (18432183)
2009
16
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (19153073)
2009
17
Oncoplastic surgery after mammary reduction and mastopexy for bilateral breast cancer lesions: report of a case. (18368323)
2008
18
Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan. (16544057)
2006
19
A case of metachronous bilateral breast cancer with bilateral radiation pneumonitis after breast-conserving therapy. (16929127)
2006
20
A comparison of bilateral breast cancers in BRCA carriers. (15941968)
2005
21
A case of bilateral breast cancer and Graves' disease. (15656338)
2004
22
BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients. (15319244)
2004
23
Paclitaxel chemotherapy in a pregnant patient with bilateral breast cancer. (15507181)
2004
24
Biopathological profile of multiple synchronous homolateral and bilateral breast cancers. (15157045)
2004
25
Molecular pathogenesis of bilateral breast cancer. (12609703)
2003
26
Bilateral breast cancer associated with diffuse scleroderma. (14659331)
2003
27
Synchronous, bilateral breast cancer: prognostic value and incidence. (14659335)
2003
28
The long-term outcome of synchronous bilateral breast cancer is worse than metachronous or unilateral tumours. (12099647)
2002
29
Prognostic significance of synchronous and metachronous bilateral breast cancer. (11571945)
2001
30
BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age. (11389159)
2001
31
Bilateral breast cancer--under age 20 years. (11287255)
2001
32
Diet and premenopausal bilateral breast cancer: a case-control study. (9065608)
1997
33
Early-stage bilateral breast cancer treated with breast-conserving surgery and definitive irradiation: the University of Pennsylvania experience. (9276360)
1997
34
Clonal analysis of bilateral breast cancer. (9816225)
1996
35
Bilateral breast cancer: early detection with mammography. (7617856)
1995
36
Clinical epidemiology of bilateral breast cancer. (8252478)
1993
37
Absence of p53 germ-line mutations in bilateral breast cancer patients. (1587536)
1992
38
Genetic epidemiology of bilateral breast cancer: a linkage analysis using the affected-pedigree-member method. (2328913)
1990
39
Possible heterogeneity in the segregation pattern of breast cancer in families with bilateral breast cancer. (3402724)
1988
40
Bilateral breast cancer: the frequency of undiagnosed cancers. (3017110)
1986
41
Bilateral breast cancer in patients with initial stage I and II disease. (7104963)
1982
42
Bilateral breast cancer in a Chinese male. (6274288)
1981
43
Bilateral breast cancer and familial aggregations. (674108)
1978
44
Simultaneous bilateral breast cancer. (852934)
1977
45
Bilateral breast cancer: biopsy of the opposite breast. (907998)
1977
46
Bilateral breast cancer what about the other breast? (1012550)
1976
47
Bilateral breast cancer. (5389668)
1969
48
Bilateral breast cancer in relation to the menses. (5811574)
1969
49
Bilateral breast cancer. (13176685)
1954
50
Bilateral breast cancer. (18143507)
1949

Variations for Bilateral Breast Cancer

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Expression for genes affiliated with Bilateral Breast Cancer

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Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

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Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.6CHEK2, BRCA1
29.5CHEK2, BRCA2
39.4RAD51, BRCA1
4
Show member pathways
9.3BRCA2, RAD51
59.2BRCA1, ATM
69.2BRCA1, ATM
79.2BRCA1, ATM
8
Show member pathways
Cell cycle37
9.2CHEK2, ATM
9
Show member pathways
9.2CHEK2, ATM
10
Show member pathways
p53 pathway37
9.2CHEK2, ATM
11
Show member pathways
9.2ATM, CHEK2
129.1PGR, ATM
138.9RAD51, BRCA1, BRCA2
14
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.8ATM, BRCA1, CHEK2
15
Show member pathways
8.8BRCA1, ATM, CHEK2
168.8CHEK2, BRCA1, ATM
178.8CHEK2, BRCA1, ATM
18
Show member pathways
8.8BRCA1, CHEK2, ATM
19
Show member pathways
Signaling Pathways in Glioblastoma37
8.7BRCA2, BRCA1, ATM
20
Show member pathways
8.7BRCA2, ATM, BRCA1
218.6RAD51, BRCA1, ATM
22
Show member pathways
Homologous recombination37
8.5ATM, BRCA2, RAD51
23
Show member pathways
8.2CHEK2, ATM, RAD51, BRCA1
24
Show member pathways
ATM Signaling Pathway37
8.2CHEK2, BRCA1, ATM, RAD51
25
Show member pathways
DNA damage response37
8.2CHEK2, RAD51, BRCA1, ATM
26
Show member pathways
8.1BRCA2, BRCA1, RAD51, ATM
27
Show member pathways
8.1BRCA2, ATM, RAD51, BRCA1
28
Show member pathways
8.1RAD51, ATM, BRCA2, BRCA1
29
Show member pathways
7.6CHEK2, BRCA1, ATM, BRCA2, RAD51
307.6BRCA2, BRCA1, CHEK2, RAD51, ATM
317.6RAD51, ATM, BRCA2, BRCA1, CHEK2
32
Show member pathways
7.6ATM, BRCA2, BRCA1, CHEK2, RAD51
33
Show member pathways
7.6RAD51, CHEK2, BRCA1, BRCA2, ATM
347.6ATM, BRCA2, BRCA1, RAD51, CHEK2

Compounds for genes affiliated with Bilateral Breast Cancer

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Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1daidzein449.9BRCA2, BRCA1
28-oxoguanine449.9BRCA2, BRCA1
3lycopene44 2410.8BRCA2, BRCA1
4indole-3-carbinol449.8BRCA1, BRCA2
517beta-hydroxysteroid449.7PGR, BRCA1
6o6-methylguanine449.6RAD51, BRCA2
7nocodazole44 1110.6CHEK2, BRCA1
8neocarzinostatin449.6ATM, CHEK2
9topotecan44 1110.5BRCA1, ATM
104-hydroxytamoxifen449.4PGR, BRCA2, BRCA1
11resveratrol44 61 24 1112.4PGR, BRCA2, BRCA1
12docetaxel44 50 61 1112.4PGR, BRCA1, BRCA2
13folate449.4PGR, BRCA1, BRCA2
14gemcitabine44 50 1111.4CHEK2, BRCA1, RAD51
15methotrexate50 44 1111.4BRCA1, BRCA2, PGR
16methylmethanesulfonate449.3BRCA2, BRCA1, RAD51
17tamoxifen44 50 28 1112.3BRCA2, BRCA1, PGR
18gold449.3BRCA1, RAD51, BRCA2
19estradiol44 24 1111.3PGR, BRCA2, BRCA1
20adpribose449.2BRCA2, BRCA1
21bpde449.2BRCA1, ATM, CHEK2
22progesterone44 28 61 24 1113.1BRCA1, PGR, BRCA2
23bleomycin44 1110.1ATM, BRCA2, BRCA1
24thymidine44 2410.1RAD51, BRCA1, BRCA2
25testosterone44 61 24 1112.0PGR, BRCA1, BRCA2
26adriamycin449.0BRCA2, PGR, CHEK2, BRCA1
27h2o2449.0RAD51, BRCA1, BRCA2
28steroid448.9PGR, BRCA2, BRCA1
29retinoic acid44 249.9BRCA2, BRCA1, CHEK2, PGR
30wortmannin448.8RAD51, ATM, CHEK2
31oligonucleotide448.8CHEK2, BRCA1, BRCA2, RAD51
32paclitaxel44 50 1110.8BRCA1, PGR, RAD51, BRCA2
33alanine448.8PGR, BRCA1, RAD51, CHEK2
34cycloheximide448.8PGR, BRCA1, RAD51, BRCA2
35doxorubicin44 50 1110.7CHEK2, ATM, BRCA1, PGR
36phosphatidylinositol448.6BRCA2, BRCA1, CHEK2, ATM
37aphidicolin448.6ATM, BRCA1, CHEK2, RAD51
38paraffin448.6BRCA2, BRCA1, ATM, PGR
39glutamine448.6BRCA2, BRCA1, ATM, PGR
40caffeine44 28 2 50 24 1113.6BRCA1, ATM, RAD51, CHEK2
41mitomycin c448.5BRCA2, ATM, BRCA1, RAD51
42polyacrylamide448.5ATM, BRCA1, RAD51, BRCA2
43atp44 289.5BRCA1, ATM, RAD51, CHEK2
44tyrosine448.3RAD51, BRCA1, CHEK2, ATM
45genistein44 28 61 2 24 1113.2BRCA1, PGR, CHEK2, BRCA2, ATM
46hydroxyurea44 50 1110.1BRCA1, RAD51, CHEK2, BRCA2, ATM
47camptothecin44 61 1110.1RAD51, CHEK2, BRCA2, BRCA1, ATM
48etoposide44 50 61 1111.1RAD51, BRCA1, CHEK2, BRCA2, ATM
49cisplatin44 50 61 1111.1ATM, BRCA1, BRCA2, RAD51, CHEK2
50estrogen448.0PGR, BRCA2, BRCA1, ATM, RAD51

GO Terms for genes affiliated with Bilateral Breast Cancer

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Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.4RAD51, CHEK2
2chromosome, telomeric regionGO:0007818.9CHEK2, ATM
3nucleoplasmGO:0056547.0RAD51, ATM, BRCA2, BRCA1, PGR, CHEK2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.6BRCA1, BRCA2
2response to gamma radiationGO:0103329.5BRCA2, CHEK2
3DNA damage induced protein phosphorylationGO:0069759.3CHEK2, ATM
4replicative senescenceGO:0903999.3CHEK2, ATM
5positive regulation of transcription, DNA-templatedGO:0458939.1CHEK2, BRCA1, BRCA2
6intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.0ATM, BRCA1, CHEK2
7response to ionizing radiationGO:0102128.9BRCA1, ATM
8reciprocal meiotic recombinationGO:0071318.9RAD51, ATM
9cellular response to DNA damage stimulusGO:0069748.4ATM, BRCA1, CHEK2, RAD51
10double-strand break repair via homologous recombinationGO:0007248.3ATM, BRCA2, BRCA1, RAD51
11DNA repairGO:0062818.3RAD51, BRCA1, BRCA2, ATM
12double-strand break repairGO:0063027.9RAD51, CHEK2, BRCA1, BRCA2, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.3RAD51, BRCA2
2protein bindingGO:0055156.8RAD51, CHEK2, PGR, BRCA1, BRCA2, ATM

Products for genes affiliated with Bilateral Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Bilateral Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet