MCID: BLT006
MIFTS: 53

Bilateral Breast Cancer malady

Categories: Cancer diseases

Aliases & Classifications for Bilateral Breast Cancer

Aliases & Descriptions for Bilateral Breast Cancer:

Name: Bilateral Breast Cancer 12 52 14 69
Bilateral Breast Carcinoma 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:6741
NCIt 47 C8287
UMLS 69 C0281267

Summaries for Bilateral Breast Cancer

Disease Ontology : 12 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards based summary : Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to synchronous bilateral breast carcinoma and breast cancer. An important gene associated with Bilateral Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. The drugs Dexamethasone and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and lung, and related phenotypes are Decreased homologous recombination repair frequency and cellular

Related Diseases for Bilateral Breast Cancer

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
id Related Disease Score Top Affiliating Genes
1 synchronous bilateral breast carcinoma 12.1
2 breast cancer 10.7
3 aorto-ventricular tunnel 10.3 BRCA1 BRCA2
4 burn scar 10.3 BRCA1 BRCA2
5 lethal congenital contracture syndrome 7 10.3 BRCA1 BRCA2
6 chronic endophthalmitis 10.3 BRCA1 BRCA2
7 neuropathy, distal hereditary motor, type viib 10.2 BRCA1 BRCA2
8 eccrine sweat gland neoplasm 10.2 BRCA1 BRCA2
9 frontal sinusitis 10.2 BRCA1 BRCA2
10 bacteremia 10.2 BRCA1 BRCA2
11 progesterone resistance 10.2 ATM CHEK2
12 syndromic x-linked intellectual disability 14 10.2 BRCA1 BRCA2
13 mouth disease 10.1 ERBB2 PGR
14 mucoepidermoid thyroid carcinoma 10.1 ERBB2 PGR
15 triple-receptor negative breast cancer 10.1 ERBB2 PGR
16 skin sarcoma 10.1 ERBB2 PGR
17 peroxisome biogenesis disorder 5b 10.1 ATM BRCA1 CHEK2
18 kunjin encephalitis 10.1 BRCA1 BRCA2 ERBB2
19 autoimmune disease of cardiovascular system 10.1 BRCA1 BRCA2 PGR
20 benign breast phyllodes tumor 10.1 PGR PTEN
21 lung clear cell-sugar-tumor 10.1 BRCA1 BRCA2 ERBB2
22 heart malignant hemangiopericytoma 10.1 BRCA1 BRCA2 PGR
23 breast pericanalicular fibroadenoma 10.1 BRCA1 BRCA2 PGR
24 intestinal neuroendocrine benign tumor 10.1 ERBB2 PGR
25 bladder colloid adenocarcinoma 10.1 BRCA1 BRCA2 ERBB2
26 epidermolysis bullosa, nonspecific, autosomal recessive 10.1 ATM BRCA1 CHEK2
27 nemaline myopathy 8, autosomal recessive 10.1 BRCA1 BRCA2 ERBB2
28 pneumonia 10.1 BRCA1 BRCA2 PGR
29 basaloid squamous cell carcinoma 10.1 ERBB2 PGR
30 infiltrating angiolipoma 10.1 ERBB2 PGR
31 breast ductal carcinoma 10.1 PGR PTEN
32 ulnar neuropathy 10.0 PGR PTEN
33 childhood teratocarcinoma of the testis 10.0 BRCA1 BRCA2 PTEN
34 bartholin's gland benign neoplasm 10.0 ESR1 PGR
35 rapsn-related fetal akinesia deformation sequence 10.0 BRCA2 CHEK2 PTEN
36 cardiovascular organ benign neoplasm 10.0 ESR1 PGR
37 appendix leiomyoma 10.0 ESR1 PGR
38 bronchus adenoma 10.0 ESR1 PGR
39 ovarian benign neoplasm 10.0 ESR1 PGR
40 plexiform neurofibroma 10.0 ESR1 PGR
41 paranasal sinus disease 10.0 ESR1 PGR
42 deafness, autosomal recessive 21 10.0 ESR1 PGR
43 hereditary breast ovarian cancer 10.0 ERBB2 ESR1
44 atypical lipomatous tumor 10.0 ESR1 PGR
45 pediatric intraocular retinoblastoma 10.0 ESR1 PGR
46 congenital disorder of glycosylation, type ic 10.0 ESR1 PGR
47 intestinal perforation 10.0 ESR1 PGR
48 perlman syndrome 10.0 ESR1 PGR
49 bladder adenocarcinoma 10.0 ESR1 PGR
50 anal neuroendocrine tumor 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to Bilateral Breast Cancer

Symptoms & Phenotypes for Bilateral Breast Cancer

GenomeRNAi Phenotypes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.62 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.62 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.62 BRCA2 PGR RAD51 BRCA1
4 Decreased homologous recombination repair frequency GR00236-A-2 10.62 BRCA2 PGR RAD51 ATM BRCA1
5 Decreased homologous recombination repair frequency GR00236-A-3 10.62 BRCA1 BRCA2 RAD51
6 Decreased viability GR00221-A-1 10.47 ESR1
7 Decreased viability GR00221-A-2 10.47 BRCA1 CHEK2 ESR1
8 Decreased viability GR00221-A-3 10.47 ATM BRCA1 CHEK2 ERBB2
9 Decreased viability GR00221-A-4 10.47 ATM CHEK2 ERBB2 ESR1
10 Decreased viability GR00301-A 10.47 BRCA1
11 Decreased viability GR00342-S-2 10.47 CHEK2
12 Decreased viability in esophageal squamous lineage GR00235-A 9.97 BRCA1 BRCA2 CHEK2 ERBB2 ESR1 PGR
13 Apoptosis resistance GR00093-A-0 9.65 ATM CHEK2 PTEN
14 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 ATM BRCA1 BRCA2 CHEK2 PTEN
15 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 ATM BRCA1 BRCA2 CHEK2 PTEN RAD51
16 Decreased viability after ionizing radiation GR00232-A-2 9.58 ATM BRCA1 BRCA2
17 Increased cell death HMECs cells GR00103-A-0 9.56 BRCA1 PGR PTEN RAD51
18 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.55 ATM BRCA1 BRCA2 CHEK2 RAD51
19 Decreased viability with cisplatin GR00101-A-4 9.5 BRCA1 BRCA2 RAD51
20 Synthetic lethal with cisplatin GR00101-A-1 9.13 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

44 (show all 19)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
2 embryo MP:0005380 10.15 ATM BRCA1 BRCA2 ERBB2 ESR1 PGR
3 endocrine/exocrine gland MP:0005379 10.14 CHEK2 ERBB2 ESR1 PGR PTEN ATM
4 behavior/neurological MP:0005386 10.13 ATM BRCA1 BRCA2 ERBB2 ESR1 PGR
5 homeostasis/metabolism MP:0005376 10.1 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
6 growth/size/body region MP:0005378 10.07 ATM BRCA1 BRCA2 ERBB2 ESR1 PTEN
7 mortality/aging MP:0010768 10.06 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
8 cardiovascular system MP:0005385 10.05 ATM BRCA1 ERBB2 ESR1 PGR PTEN
9 hematopoietic system MP:0005397 10.05 ATM BRCA1 BRCA2 CHEK2 ESR1 PGR
10 immune system MP:0005387 10.02 BRCA1 BRCA2 CHEK2 ESR1 PGR PTEN
11 integument MP:0010771 10 ATM BRCA1 BRCA2 ERBB2 ESR1 PGR
12 digestive/alimentary MP:0005381 9.96 BRCA1 BRCA2 ESR1 PTEN ERBB2
13 neoplasm MP:0002006 9.92 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
14 limbs/digits/tail MP:0005371 9.91 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN
15 nervous system MP:0003631 9.8 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
16 muscle MP:0005369 9.77 BRCA1 ERBB2 ESR1 PGR PTEN
17 normal MP:0002873 9.63 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN
18 reproductive system MP:0005389 9.5 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN
19 skeleton MP:0005390 9.1 BRCA1 BRCA2 ERBB2 ESR1 PGR PTEN

Drugs & Therapeutics for Bilateral Breast Cancer

Drugs for Bilateral Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
3
Diazepam Approved, Illicit, Vet_approved Phase 4,Phase 2 439-14-5 3016
4
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
5
Tamoxifen Approved Phase 4,Phase 3,Phase 2 10540-29-1 2733526
6
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
8
Trastuzumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 180288-69-1 9903
9
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
10
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
11
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1 56420-45-2 41867
12
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
13
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
14
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
15
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
16
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
17
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
18
Exemestane Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 107868-30-4 60198
19
Remifentanil Approved Phase 4 132875-61-7 60815
20
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
21
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
22
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
23
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
24 Parecoxib Approved Phase 4 198470-84-7
25
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
26
Aprepitant Approved, Investigational Phase 4,Phase 3 170729-80-3 151165 6918365
27
Fosaprepitant Approved Phase 4,Phase 3 172673-20-0 219090
28
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
29
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
30 tannic acid Approved, Nutraceutical Phase 4
31
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
32
Docetaxel Approved May 1996, Investigational Phase 4,Phase 2,Phase 3,Phase 1 114977-28-5 148124 9877265
33
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3,Phase 1 31703
34
Substance P Investigational Phase 4,Phase 3 33507-63-0 44359816
35 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
36 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
38 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
39
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Selective Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2
41
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
42 Serotonin Agents Phase 4,Phase 3,Phase 2
43 Serotonin Antagonists Phase 4,Phase 3,Phase 2
44 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
47 Albumin-Bound Paclitaxel Phase 4,Phase 3,Phase 2,Phase 1
48 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Early Phase 1
49 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 832)
id Name Status NCT ID Phase
1 Study the Role of Positron Emission Mammography in Pre-surgical Planning for Breast Cancer Unknown status NCT00484614 Phase 4
2 Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation Unknown status NCT01216254 Phase 4
3 COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined Completed NCT01361789 Phase 4
4 Sentinel Lymph Node Mapping Post-Injection Site Pain Completed NCT02065232 Phase 4
5 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
6 Opioid Free Anesthesia: What About Patient Comfort? Completed NCT02882035 Phase 4
7 Carotene and Retinol Efficacy Trial Completed NCT00712647 Phase 4
8 TAP Block in DIEP or Free MS-TRAM Donor Site: A RCT Completed NCT01398982 Phase 4
9 Infusion of a Local Anaesthetic in the Surgical After Modified Radical Mastectomy With Expander Completed NCT01389934 Phase 4
10 Exercise and Phytoestrogens: Effect on Factors Predisposing to Cardiovascular Disease(CVD) in Postmenopausal Women Completed NCT01048606 Phase 4
11 Breast Reconstruction With Acellular Dermal Matrix in the Setting of Breast Cancer Treatment Recruiting NCT02061527 Phase 4
12 Safety and Efficacy of Trastuzumab as Part of Breast Cancer Treatment Regimen Recruiting NCT02419742 Phase 4
13 Huaier Granule in Treating Women With Triple Negative Breast Cancer Recruiting NCT02615457 Phase 4
14 Clinical Utility Study of a Low-Cost Hand-Held Breast Scanner Recruiting NCT02597452 Phase 4
15 Tomosynthesis Versus Digital Mammography in a Population-based Screening Program Recruiting NCT02590315 Phase 4
16 Neoadjuvant Chemotherapy With or Without Huaier Granule in Treating Women With Locally Advanced Breast Cancer That Can Be Removed By Surgery Recruiting NCT02627248 Phase 4
17 Intraoperative Ketamine on Chronic Pain After Mastectomy Recruiting NCT02729805 Phase 4
18 A Clinical Trial About the Contribution of Manual Lymph Drainage in Complex Physical Therapy for Patients With Lymphoedema Secondary to Mastectomy Recruiting NCT01152099 Phase 4
19 Prevention of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients. Active, not recruiting NCT01913990 Phase 4
20 Breast Cancer Screening With MRI in Women Aged 50-75 Years With Extremely Dense Breast Tissue: the DENSE Trial Active, not recruiting NCT01315015 Phase 4
21 A Study to Evaluate Exemestane Tablets Combined With Ovarian Function Suppression/Ablation in Treatment of Premenopausal Breast Cancer Patients With CYP2D6*10 Mutations (STEP) Not yet recruiting NCT03137368 Phase 4
22 Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn Not yet recruiting NCT03007381 Phase 4
23 Histamine Receptor 2 Antagonists as Enhancers of Anti-Tumour Immunity Not yet recruiting NCT03145012 Phase 4
24 Contrast-Enhanced Digital Mammography (CEDM) for Identifying a Change in Management of Women With Newly Diagnosed Breast Cancer Terminated NCT01303419 Phase 4
25 Correlation Between Genetic Variants and Long-term Cardiac Effects Induced by Doxorubicin in Breast Cancer Patients Unknown status NCT02078388 Phase 2, Phase 3
26 Adjuvant Hormone Therapy in Treating Women With Operable Breast Cancer Unknown status NCT00002460 Phase 3
27 Resource-sparing Post-mastectomy Radiotherapy in Breast Cancer Unknown status NCT01452672 Phase 3
28 Trial of Concurrent Versus Sequential Tamoxifen With Radiotherapy in Breast Cancer Patients Unknown status NCT00896155 Phase 3
29 Standard Versus Continuous Capecitabine in Advanced Breast Cancer Unknown status NCT00418028 Phase 2, Phase 3
30 Cognitive Behavioral Therapy (CBT) and Physical Exercise for Climacteric Symptoms in Breast Cancer Patients Experiencing Treatment-Induced Menopause: a Multicenter Randomized Trial Unknown status NCT00582244 Phase 3
31 Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates Unknown status NCT01236781 Phase 2, Phase 3
32 Study of Suitable Schedule of Docetaxel,Anthracycline and Cyclophosphamide in Adjuvant Therapy of Beast Cancer Unknown status NCT00525642 Phase 2, Phase 3
33 Trastuzumab or Lapatinib Ditosylate in Treating Women With Early Breast Cancer Unknown status NCT01104571 Phase 3
34 Partnership for Healthy Seniors Unknown status NCT00379743 Phase 3
35 Vinorelbine Versus Gemcitabine Plus Vinorelbine in Metastatic Breast Cancer Patients Completed NCT00128310 Phase 3
36 Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Docetaxel (AC-Doc) Versus Dose-Dense Doxorubicin and Docetaxel (ADoc) in Breast Cancer Completed NCT00793377 Phase 3
37 Efficacy and Safety of Gadobutrol 1.0 Molar (Gadovist) for Breast MRI Completed NCT01067976 Phase 3
38 Efficacy and Safety of Gadobutrol 1.0 Molar (Gadovist) for Breast Magnetic Resonance Imaging (MRI) Completed NCT01104584 Phase 3
39 Effect of GM1 in Prevention of Taxanes Induced Neurotoxicity in Operable Breast Cancer Completed NCT02468739 Phase 3
40 Bevacizumab + Endocrine Treatment vs Endocrine Treatment as First Line Treatment in Postmenopausal Patients With Advanced or Metastatic Breast Cancer Completed NCT00545077 Phase 3
41 Adjuvant Epirubicin/Cytoxan Followed By A Taxane VS. Epirubicin/Taxane As Treatment For Node-Positive Breast Cancer Completed NCT00140075 Phase 3
42 Study Comparing Concomitant Docetaxel + Gemcitabine to Sequential Therapy of Docetaxel Followed by Gemcitabine Completed NCT00294385 Phase 3
43 Prognostic Study of Sentinel Lymph Node and Bone Marrow Metastases in Women With Stage I or Stage IIA Breast Cancer Completed NCT00003854 Phase 3
44 A Study to Compare ETC vs. EC-TX and Ibandronate vs. Observation in Patients With Node-positive Primary Breast Cancer (GAIN) Completed NCT00196872 Phase 3
45 BREAST CANCER AND EXERCISE Completed NCT00639210 Phase 3
46 Diet and Breast Cancer Prevention Trial Completed NCT00148057 Phase 3
47 EC (Epirubicin, Cyclophosphamide) Followed by T (Docetaxel) Versus ET (Epirubicin, Docetaxel) Followed by X (Capecitabine) as Adjuvant Chemotherapy for Node Positive Operable Breast Cancer Patients Completed NCT00129935 Phase 3
48 Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy Completed NCT00115713 Phase 3
49 A Study of Vinflunine Plus Gemcitabine Versus Paclitaxel Plus Gemcitabine in Patients With Advanced Breast Cancer Completed NCT02054338 Phase 3
50 PET and MRI in the Follow-up of Neoadjuvant Chemotherapy of Breast Cancer Completed NCT00236275 Phase 3

Search NIH Clinical Center for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

Genetic tests related to Bilateral Breast Cancer:

id Genetic test Affiliating Genes
1 Bilateral Breast Carcinoma 29

Anatomical Context for Bilateral Breast Cancer

MalaCards organs/tissues related to Bilateral Breast Cancer:

39
Breast, Prostate, Lung, Testes, Cervix, Ovary, Pituitary

Publications for Bilateral Breast Cancer

Articles related to Bilateral Breast Cancer:

(show top 50) (show all 205)
id Title Authors Year
1
pCR rates in patients with bilateral breast cancer after neoadjuvant anthracycline-taxane based-chemotherapy - A retrospective pooled analysis of individual patients data of four German neoadjuvant trials. ( 28063331 )
2017
2
BILATERAL BREAST CANCER: DIAGNOSIS AND PROGNOSIS. ( 27483711 )
2016
3
Helical tomotherapy for bilateral breast cancer: Clinical experience. ( 27253152 )
2016
4
Unilateral Arm Urticaria Presenting as a Paraneoplastic Manifestation of Metachronous Bilateral Breast Cancer. ( 26933416 )
2016
5
Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls. ( 27284253 )
2016
6
Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. ( 27539136 )
2016
7
Femoral Placement of Totally Implantable Venous Access Ports in Patients with Bilateral Breast Cancer. ( 26855441 )
2016
8
Co-existence of a giant cell tumour of the tendon sheath and schwannoma in a patient with bilateral breast cancer: A potential cause of false positive findings in (18)F-FDG PET/CT studies. ( 27329560 )
2016
9
Disease evolution and heterogeneity in bilateral breast cancer. ( 27904775 )
2016
10
Bilateral breast cancer resection performed under the bilateral transversus thoracic muscle plane block. ( 27555202 )
2016
11
A case of synchronous multiple bilateral breast cancer after breast augmentation. ( 26722625 )
2015
12
Impact of bilateral breast cancer on prognosis: synchronous versus metachronous tumors. ( 25735321 )
2015
13
Breast-Conserving Surgery in Bilateral Breast Cancer. ( 26265365 )
2015
14
Bilateral breast cancer, synchronous and metachronous; differences and outcome. ( 26268697 )
2015
15
Surgical management for early-stage bilateral breast cancer patients in china. ( 25874699 )
2015
16
Use of tomotherapy in treatment of synchronous bilateral breast cancer: dosimetric comparison study. ( 25605345 )
2015
17
Metabolic flare phenomenon on 18 fluoride-fluorodeoxy glucose positron emission tomography-computed tomography scans in a patient with bilateral breast cancer treated with second-line chemotherapy and bevacizumab. ( 25829734 )
2015
18
Multifocal Bilateral Breast Cancer and Breast Follicular Lymphoma: A Simple Coincidence? ( 26472982 )
2015
19
Bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection: A case report. ( 26137129 )
2015
20
Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer. ( 26399280 )
2015
21
Bilateral breast cancer with a unilateral carcinoma within a fibroadenoma: A case report. ( 26622700 )
2015
22
Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient: a random association? ( 26399842 )
2015
23
A rare recurrence of bilateral breast cancer in the esophagus coincidentally associated with primary gastric cancer: a case report. ( 24533645 )
2014
24
Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer. ( 25112434 )
2014
25
Primary synchronous bilateral breast cancer. ( 25494117 )
2014
26
Prognosis of synchronous bilateral breast cancer: a review and meta-analysis of observational studies. ( 25007962 )
2014
27
Periductal stromal tumor of the breast with synchronous bilateral breast cancer. ( 24982380 )
2014
28
Morphoimmunohistochemical characteristics of synchronous bilateral breast cancer. ( 25257431 )
2014
29
Primary Squamous Cell Carcinoma of the Breast After Cured Bilateral Breast Cancer. ( 25398815 )
2014
30
A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer. ( 24498881 )
2014
31
A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors. ( 24736632 )
2014
32
The molecular and clinicopathologic characteristics of bilateral breast cancer. ( 24005135 )
2013
33
Case report of small bowel obstruction caused by small intestinal metastasis of bilateral breast cancer. ( 24137245 )
2013
34
Synchronous bilateral breast cancer in a male. ( 24319497 )
2013
35
Histo-biological comparative analysis of bilateral breast cancer. ( 24062258 )
2013
36
Value of bilateral breast cancer for identification of rare recessive at-risk alleles: evidence for the role of homozygous GEN1 c.2515_2519delAAGTT mutation. ( 23104382 )
2013
37
A case of synchronous bilateral breast cancer with different pathological responses to neoadjuvant chemotherapy with different biological character. ( 23875131 )
2013
38
The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. ( 23296702 )
2013
39
A young woman with bilateral breast cancer: identifying a genetic cause and implications for management. ( 23667202 )
2013
40
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer. ( 24382440 )
2013
41
Synchronous bilateral breast cancer in a patient with kindler syndrome. ( 22054710 )
2012
42
Dosimetric advantages of generalised equivalent uniform dose-based optimisation on dose-volume objectives in intensity-modulated radiotherapy planning for bilateral breast cancer. ( 23091290 )
2012
43
Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature. ( 22672556 )
2012
44
Clinicopathological features in bilateral breast cancer. ( 23167382 )
2012
45
Increased risks of third primary cancers of non-breast origin among women with bilateral breast cancer. ( 22713658 )
2012
46
Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand. ( 22799341 )
2012
47
Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer. ( 22520019 )
2012
48
Dermatomyositis as paraneoplastic syndrome of peritoneal and ovarian relapse after long-term complete remission in patient with metastatic bilateral breast cancer. ( 22816241 )
2012
49
Ductal carcinoma in situ that involves sclerosing adenosis: high frequency of bilateral breast cancer occurrence. ( 23083502 )
2012
50
Papillary-serous adenocarcinoma of the uterine cervix during tamoxifen therapy after bilateral breast cancer. ( 23155282 )
2012

Variations for Bilateral Breast Cancer

Expression for Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for Bilateral Breast Cancer

Pathways related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 ATM BRCA1 CHEK2 ERBB2 ESR1 PTEN
2
Show member pathways
13.59 ATM BRCA1 CHEK2 ERBB2 ESR1 PGR
3
Show member pathways
13.23 ATM BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
13.04 ATM BRCA1 BRCA2 CHEK2 RAD51
5
Show member pathways
12.79 ATM BRCA1 CHEK2 PTEN
6
Show member pathways
12.74 ATM BRCA1 BRCA2 CHEK2 RAD51
7
Show member pathways
12.66 ATM BRCA1 BRCA2 ERBB2 ESR1 PGR
8 12.51 BRCA2 ERBB2 PTEN RAD51
9
Show member pathways
12.41 ATM BRCA1 BRCA2 CHEK2 ESR1 RAD51
10 12.37 ATM BRCA1 ERBB2 PTEN
11
Show member pathways
12.35 ATM BRCA1 BRCA2 RAD51
12 12.32 ATM BRCA1 BRCA2 CHEK2 RAD51
13
Show member pathways
12.21 ATM BRCA1 CHEK2
14
Show member pathways
12.17 ATM BRCA1 CHEK2 PTEN RAD51
15
Show member pathways
12.16 ATM BRCA1 BRCA2 RAD51
16
Show member pathways
12.11 ATM BRCA1 CHEK2 PTEN
17
Show member pathways
12.07 BRCA1 CHEK2 ESR1 PGR
18
Show member pathways
11.98 ATM BRCA1 BRCA2 RAD51
19
Show member pathways
11.96 BRCA2 ERBB2 RAD51
20 11.94 ATM CHEK2 PTEN
21 11.86 ATM ERBB2 PTEN
22
Show member pathways
11.81 ERBB2 ESR1 PGR
23 11.75 BRCA1 BRCA2 RAD51
24
Show member pathways
11.67 ATM BRCA1 CHEK2 RAD51
25 11.62 ATM BRCA1 ERBB2
26
Show member pathways
11.47 ATM BRCA1 BRCA2 CHEK2 RAD51
27 11.37 ATM BRCA1 CHEK2
28 11.35 ATM BRCA1 BRCA2 CHEK2 ESR1 PTEN
29 11.33 ATM BRCA1 CHEK2 PTEN
30 11.25 BRCA2 CHEK2 ESR1
31 11.24 ESR1 PTEN
32 11.17 ATM BRCA1
33 11.17 ATM BRCA1 CHEK2 ERBB2 PTEN
34 11.16 ATM PGR
35 11.12 ATM BRCA1 RAD51
36 11.02 ATM CHEK2
37 10.99 ATM PTEN
38 10.93 ATM BRCA1

GO Terms for Bilateral Breast Cancer

Cellular components related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.91 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
2 nucleoplasm GO:0005654 9.56 ATM BRCA1 BRCA2 CHEK2 ESR1 PGR
3 nuclear chromosome, telomeric region GO:0000784 9.5 ATM BRCA2 RAD51
4 condensed nuclear chromosome GO:0000794 9.4 BRCA1 RAD51
5 condensed chromosome GO:0000793 9.37 BRCA1 RAD51
6 PML body GO:0016605 9.33 CHEK2 PTEN RAD51
7 lateral element GO:0000800 8.8 BRCA1 BRCA2 RAD51

Biological processes related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.94 ATM BRCA1 CHEK2 PTEN
2 cell cycle GO:0007049 9.93 ATM BRCA1 BRCA2 CHEK2
3 positive regulation of transcription, DNA-templated GO:0045893 9.91 BRCA1 BRCA2 CHEK2 ESR1
4 cellular response to DNA damage stimulus GO:0006974 9.85 ATM BRCA1 BRCA2 CHEK2 RAD51
5 heart development GO:0007507 9.81 ATM ERBB2 PTEN
6 regulation of apoptotic process GO:0042981 9.8 ATM BRCA1 CHEK2 ESR1
7 protein autophosphorylation GO:0046777 9.77 ATM CHEK2 ERBB2
8 DNA repair GO:0006281 9.77 ATM BRCA1 BRCA2 CHEK2 RAD51
9 regulation of signal transduction by p53 class mediator GO:1901796 9.74 ATM BRCA1 CHEK2
10 DNA recombination GO:0006310 9.72 BRCA1 BRCA2 RAD51
11 double-strand break repair GO:0006302 9.69 BRCA1 BRCA2 CHEK2
12 response to gamma radiation GO:0010332 9.63 BRCA2 CHEK2
13 telomere maintenance via recombination GO:0000722 9.62 BRCA2 RAD51
14 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.62 BRCA2 CHEK2
15 reciprocal meiotic recombination GO:0007131 9.61 ATM RAD51
16 female gonad development GO:0008585 9.6 ATM BRCA2
17 response to X-ray GO:0010165 9.58 BRCA2 RAD51
18 DNA double-strand break processing GO:0000729 9.58 ATM BRCA1
19 cellular response to gamma radiation GO:0071480 9.58 ATM CHEK2 RAD51
20 replicative senescence GO:0090399 9.56 ATM CHEK2
21 double-strand break repair via homologous recombination GO:0000724 9.56 ATM BRCA1 BRCA2 RAD51
22 DNA damage induced protein phosphorylation GO:0006975 9.54 ATM CHEK2
23 chromosome organization involved in meiotic cell cycle GO:0070192 9.52 ATM RAD51
24 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.5 BRCA1 BRCA2 CHEK2
25 chordate embryonic development GO:0043009 9.48 BRCA1 BRCA2
26 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 ATM BRCA1 BRCA2 CHEK2
27 mitotic recombination-dependent replication fork processing GO:1990426 9.43 BRCA2 RAD51
28 DNA synthesis involved in DNA repair GO:0000731 9.26 ATM BRCA1 BRCA2 RAD51
29 strand displacement GO:0000732 8.92 ATM BRCA1 BRCA2 RAD51

Molecular functions related to Bilateral Breast Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.8 ATM BRCA1 BRCA2 ESR1 PGR RAD51
2 nucleotide binding GO:0000166 9.46 ATM CHEK2 ERBB2 RAD51
3 protein C-terminus binding GO:0008022 9.43 BRCA2 ERBB2 RAD51
4 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.4 ESR1 PGR
5 steroid binding GO:0005496 9.37 ESR1 PGR
6 enzyme binding GO:0019899 9.26 BRCA1 ESR1 PGR PTEN
7 identical protein binding GO:0042802 9.02 CHEK2 ERBB2 ESR1 PTEN RAD51

Sources for Bilateral Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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