MCID: BLT006
MIFTS: 50

Bilateral Breast Cancer malady

Cancer diseases category

Summaries for Bilateral Breast Cancer

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

MalaCards: Bilateral Breast Cancer, also known as bilateral breast carcinoma, is related to breast cancer and male breast cancer. An important gene associated with Bilateral Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are FOXM1 transcription factor network and Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. The compounds cycloheximide and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and ovary, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Aliases & Classifications for Bilateral Breast Cancer

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

bilateral breast cancer 8 44 60
bilateral breast carcinoma 8


External Ids:

Disease Ontology8 DOID:6741
NCIt39 C8287

Related Diseases for Bilateral Breast Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bilateral Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7PGR, ESR1, ACP1, BRCA2, BRCA1
2male breast cancer30.8PGR, BRCA2, BRCA1, ESR1
3gynecomastia30.3BRCA2, BRCA1, PGR, ESR1
4prostate cancer30.3ATM, GSTP1, ACP1, CHEK2, FHIT
5endometrial carcinoma30.0MLH1, PGR, ESR1
6osteosarcoma30.0ESR1, CHEK2
7li-fraumeni syndrome30.0ESR1, PGR
8ductal carcinoma in situ30.0BRCA2, ESR1, BRCA1, PGR
9acute leukemia30.0ACP1, ATM, GSTP1, FHIT
10ataxia telangiectasia30.0CHEK2, BRCA1, RAD51, ATM, BRCA2, DRD2
11lung cancer30.0GSTP1, ATM, FHIT, CHEK2
12hepatocellular carcinoma30.0ACP1, HIC1, FHIT, BRCA2, GSTP1
13ovarian cancer30.0ESR1, MLH1, GSTP1, FHIT, BRCA2, BRCA1
14leukemia30.0BRCA1, GSTP1, ACP1, RAD51, CHEK2, ATM
15adenocarcinoma30.0FHIT, BRCA2, MLH1, BRCA1, CHEK2, HIC1
16breast disease10.5
17peutz-jeghers syndrome10.3
18prostatitis10.2
19non-hodgkin lymphoma10.1
20breast lymphoma10.1
21endometrial adenocarcinoma10.1
22burns10.0
23breast reconstruction10.0
24papillary serous adenocarcinoma10.0
25diffuse scleroderma10.0
26klinefelter's syndrome10.0
27breast osteosarcoma10.0
28sporadic breast cancer10.0
29synchronous bilateral breast carcinoma10.0
30sclerosing adenosis of breast10.0
31duodenitis10.0
32graves' disease10.0
33breast angiosarcoma10.0
34angiosarcoma10.0
35asthma10.0
36breast adenocarcinoma10.0
37breast carcinoma in situ10.0
38dermatomyositis10.0
39in situ carcinoma10.0
40intestinal obstruction10.0
41lymphoblastic leukemia10.0
42papillary adenocarcinoma10.0
43peritonitis10.0
44pituitary cancer10.0
45scleroderma10.0
46small intestine cancer10.0
47deficiency anemia10.0BRCA1
48breast-ovarian cancer, familial, 210.0BRCA2
49infertility10.0ESR1
50thyroid cancer10.0FHIT

Graphical network of the top 20 diseases related to Bilateral Breast Cancer:



Diseases related to bilateral breast cancer

Clinical Features for Bilateral Breast Cancer

About this section

Drugs & Therapeutics for Bilateral Breast Cancer

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bilateral Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Bilateral Breast Cancer

Search NIH Clinical Center for Bilateral Breast Cancer

Search CenterWatch for Bilateral Breast Cancer

Genetic Tests for Bilateral Breast Cancer

About this section

Anatomical Context for Bilateral Breast Cancer

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Bilateral Breast Cancer:

32
Breast, Prostate, Ovary, Testes, Pituitary, Lymph node, Small intestine, Lung, Cervix

Animal Models for Bilateral Breast Cancer or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Bilateral Breast Cancer:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.2PGR, KIF22
2MP:00053719.8BRCA2, DRD2, HIC1, NBR1
3MP:00020069.6PGR, HIC1, CHEK2, MLH1, DRD2, FHIT
4MP:00107719.6BRCA1, BRCA2, FHIT, DRD2, HIC1, GSTP1
5MP:00053799.4BRCA1, BRCA2, DRD2, MLH1, ATM
6MP:00053909.1NBR1, ESR1, PGR, HIC1, DRD2, BRCA2
7MP:00053819.1BRCA1, BRCA2, FHIT, DRD2, MLH1, HIC1
8MP:00053978.9BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
9MP:00107688.5BRCA1, BRCA2, FHIT, DRD2, MLH1, ATM
10MP:00053878.5BRCA1, BRCA2, FHIT, DRD2, ATM, CHEK2
11MP:00053848.5ATM, MLH1, DRD2, BRCA2, BRCA1, CHEK2

Publications for Bilateral Breast Cancer

About this section
Sources:
50PubMed
See all sources

Articles related to Bilateral Breast Cancer:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Interactions of hormone replacement therapy, body weight and bilateral oophorectomy in breast cancer risk. (24423614)
2014
2
The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. (23296702)
2013
3
A case of synchronous bilateral breast cancer with different pathological responses to neoadjuvant chemotherapy with different biological character. (23875131)
2013
4
The molecular and clinicopathologic characteristics of bilateral breast cancer. (24005135)
2013
5
Case report of small bowel obstruction caused by small intestinal metastasis of bilateral breast cancer. (24137245)
2013
6
A young woman with bilateral breast cancer: identifying a genetic cause and implications for management. (23667202)
2013
7
Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma. (24373500)
2013
8
Synchronous bilateral male breast cancer: a case report. (22807945)
2012
9
Synchronous bilateral breast cancer in a patient with kindler syndrome. (22054710)
2012
10
Clinicopathological features in bilateral breast cancer. (23167382)
2012
11
Multimodel assessment of BRCA1 mutations in Taiwanese (ethnic Chinese) women with early-onset, bilateral or familial breast cancer. (22277901)
2012
12
Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature. (22672556)
2012
13
Detection of bilateral breast cancer at biennial screening mammography in the Netherlands: a population-based study. (21474705)
2011
14
Primary bilateral ovarian and uterine Burkitt's lymphoma following chemotherapy for breast cancer. (19756677)
2010
15
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study. (20104584)
2010
16
Synchronous bilateral breast cancer in an aged male patient. (20502060)
2010
17
Prognosis of synchronous bilateral breast cancer. (19283743)
2009
18
Scintimammography with high resolution dedicated breast camera and mammography in multifocal, multicentric and bilateral breast cancer detection: a comparative study. (18432183)
2009
19
Cutaneous angiosarcoma after breast conserving treatment for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case report and review of the literature. (19736894)
2009
20
Bilateral Nonsynchronous Male Breast Cancer: Two Case Reports. (20824021)
2008
21
Clinical course of 771 patients with bilateral breast cancer: characteristics associated with overall and recurrence-free survival. (18269777)
2007
22
Human leukocyte antigen as a predictive factor of developing bilateral breast cancer in Japanese women. (16959002)
2006
23
On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancer. (16496408)
2006
24
Simultaneous bilateral breast cancer in a male: a case report and review of the literature. (16315841)
2005
25
Paclitaxel chemotherapy in a pregnant patient with bilateral breast cancer. (15507181)
2004
26
Biopathological profile of multiple synchronous homolateral and bilateral breast cancers. (15157045)
2004
27
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer. (14562025)
2003
28
Therapeutic controversies in bilateral breast cancer. (12924462)
2003
29
Molecular cytogenetic investigations of synchronous bilateral breast cancer. (12944548)
2003
30
Bilateral breast cancer--under age 20 years. (11287255)
2001
31
Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male. (11434671)
2001
32
Initial experiences of women from hereditary breast cancer families after bilateral prophylactic mastectomy: a retrospective study. (10873354)
2000
33
Efficacy of Breast Conservation Therapy in Early Stage Bilateral Breast Cancer. (11348254)
1999
34
Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers. (10469748)
1999
35
Clonal analysis of bilateral breast cancer. (9816225)
1996
36
Estrogen and progesterone receptor content in bilateral breast cancer. (7651928)
1995
37
Absence of p53 germ-line mutations in bilateral breast cancer patients. (1587536)
1992
38
Misdiagnosis of bilateral breast cancer. (1498733)
1992
39
A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. I. Segregation analysis. (3472000)
1987
40
Bilateral breast cancer. (4079423)
1985
41
Hypophyseal tumor and gynecomastia preceding bilateral breast cancer development in a man. (6704924)
1984
42
Peutz-Jeghers syndrome. Association of duodenal and bilateral breast cancers in the same patient. (6321116)
1984
43
Bilateral breast cancer in a Chinese male. (6274288)
1981
44
The incidence of bilateral breast cancer: II. A proposed model for the analysis of coincidental tumours. (7248146)
1981
45
Familial bilateral breast cancer. (6265708)
1981
46
Biological and histological characteristics of simultaneous bilateral breast cancer. (6107724)
1980
47
Bilateral breast cancer and familial aggregations. (674108)
1978
48
Bilateral breast cancer-biopsy of contralateral breast. (918120)
1977
49
Bilateral breast cancer, clinical and pathological review. (5028480)
1972
50
Bilateral breast cancer in relation to the menses. (5811574)
1969

Genetic Variations for Bilateral Breast Cancer

About this section

Expression for genes affiliated with Bilateral Breast Cancer

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bilateral Breast Cancer

Search GEO for disease gene expression data for Bilateral Breast Cancer.

Pathways for genes affiliated with Bilateral Breast Cancer

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 29KEGG, 49PharmGKB, 4Cell Signaling Technology
See all sources

Pathways related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CHEK2, BRCA2
2
Hide members
10.2CHEK2, ATM
3
Hide members
10.2RAD51, BRCA2
4
Hide members
10.2ATM, BRCA1
5
Hide members
10.0BRCA1, ATM, CHEK2
610.0BRCA1, ATM, CHEK2
7
Hide members
10.0CHEK2, ATM, BRCA1
810.0BRCA1, ATM, CHEK2
9
Hide members
10.0BRCA1, BRCA2, ATM
10
Hide members
10.0RAD51, ATM, BRCA2
1110.0MLH1, ATM, PGR
1210.0MLH1, CHEK2, GSTP1
139.9BRCA1, ATM, HIC1
14
Hide members
9.9RAD51, CHEK2, ATM, BRCA1
159.9RAD51, CHEK2, ATM, BRCA1
16
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
17
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
18
Hide members
9.9BRCA1, BRCA2, ATM, RAD51
19
Cell cycle Cell cycle (generic schema)
Hide members
9.9ESR1, PGR, CHEK2, BRCA1
209.8RAD51, MLH1, BRCA2, BRCA1
219.8GSTP1, RAD51, MLH1, BRCA2
229.7BRCA1, BRCA2, ATM, CHEK2, RAD51
23
Hide members
9.7BRCA1, BRCA2, MLH1, ATM, RAD51
24
Hide members
9.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
259.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
269.6BRCA1, BRCA2, ATM, CHEK2, RAD51, ESR1
27
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.6RAD51, CHEK2, ATM, MLH1, BRCA2, BRCA1
28
Hide members
9.6BRCA1, BRCA2, MLH1, ATM, CHEK2, RAD51

Compounds for genes affiliated with Bilateral Breast Cancer

About this section
Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5BRCA1, BRCA2
2ici 1643844410.5ESR1, PGR
3Ethynodiol Diacetate1110.5ESR1, PGR
4resveratrol44 59 11 2413.5BRCA2, PGR
5Allylestrenol1110.4ESR1, PGR
6adriamycin4410.4PGR, GSTP1, CHEK2
7Etonogestrel1110.4PGR, ESR1
8daidzein4410.4BRCA2, ESR1, BRCA1
9idoxifene4410.4ESR1, PGR
10droloxifene4410.4ESR1, PGR, GSTP1
11nomegestrol acetate4410.3GSTP1, ESR1, PGR
12lycopene44 2411.3BRCA1, BRCA2, GSTP1
13h2o24410.3RAD51, ACP1
14bpde4410.3GSTP1, BRCA1, ATM, CHEK2
154-hydroxytamoxifen4410.2ESR1, PGR, BRCA2, BRCA1
16o6-methylguanine4410.2GSTP1, RAD51, MLH1, BRCA2
17bleomycin44 1111.2ATM, GSTP1, BRCA2, BRCA1
18gemcitabine44 49 1112.2CHEK2, MLH1, BRCA1, RAD51
19caffeine44 49 28 2 11 2415.2BRCA1, RAD51, CHEK2, ATM
20sodium bisulfite4410.2MLH1, BRCA1, FHIT, GSTP1
21hydroxyurea44 49 1112.2BRCA1, BRCA2, ATM, RAD51, CHEK2
22platinum44 4911.2GSTP1, BRCA1, MLH1
23triphenylethylene4410.2PGR, ESR1
24indole-3-carbinol4410.1BRCA1, BRCA2, ESR1
25aphidicolin4410.1RAD51, BRCA1, FHIT, ATM, CHEK2
26thymidylate4410.1GSTP1, RAD51, BRCA1, MLH1
27mitomycin c4410.1RAD51, ATM, BRCA2, GSTP1, BRCA1
28neocarzinostatin4410.1ATM, CHEK2
29docetaxel44 49 59 1113.1GSTP1, PGR, ESR1, BRCA1, BRCA2
30methotrexate44 49 1112.1BRCA1, BRCA2, ESR1, GSTP1, PGR
31methylmethanesulfonate4410.0RAD51, BRCA2, BRCA1
32folate4410.0PGR, MLH1, BRCA2, BRCA1, GSTP1
335fluorouracil4410.0MLH1, PGR, ESR1, BRCA1, GSTP1
34cyclophosphamide44 49 1112.0GSTP1, PGR, ESR1, BRCA1
35polyacrylamide449.9MLH1, FHIT, BRCA2, BRCA1, RAD51, ATM
36steroid449.9ESR1, FHIT, BRCA2, BRCA1
37adenine44 11 2411.9RAD51, MLH1, BRCA1, ACP1
38camptothecin44 59 1111.8RAD51, ATM, CHEK2, MLH1, BRCA2, BRCA1
39progesterone44 59 28 11 2413.7ESR1, MLH1, PGR, BRCA1, BRCA2, FHIT
40topotecan44 1110.7GSTP1, BRCA1, ATM
415-aza-2deoxycytidine449.6ESR1, GSTP1, BRCA1, PGR, FHIT, HIC1
42paclitaxel44 49 1111.6GSTP1, PGR, MLH1, BRCA2, BRCA1, FHIT
43paraffin449.6BRCA2, GSTP1, ESR1, BRCA1, PGR, ATM
44alanine449.6PGR, MLH1, CHEK2, GSTP1, BRCA1, RAD51
45etoposide44 49 59 1112.5RAD51, MLH1, ATM, CHEK2, BRCA2, BRCA1
46genistein44 28 59 2 11 2414.5GSTP1, ESR1, CHEK2, ACP1, ATM, BRCA2
47doxorubicin44 49 1111.5BRCA1, MLH1, ATM, PGR, ACP1, GSTP1
48vegf449.4DRD2, RAD51, GSTP1, ACP1, BRCA1, PGR
49retinoic acid44 2410.3ESR1, GSTP1, PGR, CHEK2, MLH1, BRCA2
50cisplatin44 49 59 1111.9BRCA2, GSTP1, BRCA1, FHIT, DRD2, MLH1

GO Terms for genes affiliated with Bilateral Breast Cancer

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.4ESR1, RAD51, PGR, CHEK2, ATM, BRCA2

Biological processes related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.3ATM, CHEK2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3reciprocal meiotic recombinationGO:00713110.1RAD51, ATM, MLH1
4double-strand break repair via homologous recombinationGO:00072410.1RAD51, ATM, BRCA2, BRCA1
5replicative senescenceGO:09039910.1CHEK2, ATM
6regulation of stress-activated MAPK cascadeGO:03287210.0GSTP1, NBR1
7response to DNA damage stimulusGO:00697410.0BRCA1, ATM, CHEK2, RAD51
8double-strand break repairGO:00630210.0BRCA1, BRCA2, ATM, CHEK2, RAD51
9DNA repairGO:0062819.9BRCA1, BRCA2, ATM, KIF22, RAD51
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.8HIC1, CHEK2, ATM, MLH1, BRCA1
11positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:0435179.8HIC1, ATM

Molecular functions related to Bilateral Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.7BRCA2, MLH1, RAD51
2identical protein bindingGO:0428029.6ESR1, RAD51, CHEK2, DRD2, FHIT
3protein bindingGO:0055157.5GSTP1, BRCA1, BRCA2, FHIT, DRD2, MLH1

Products for genes affiliated with Bilateral Breast Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bilateral Breast Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet