MCID: BLD033
MIFTS: 49

Bile Duct Adenoma malady

Cancer diseases, Liver diseases categories
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Summaries for Bile Duct Adenoma

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Disease Ontology:8 An adenoma and biliary tract cancer that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards based summary: Bile Duct Adenoma, also known as adenoma bile duct, is related to adenoma and cholangiocarcinoma. An important gene associated with Bile Duct Adenoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Signal transduction JNK pathway and LKB1 signaling events. The compounds ddp-cr and taxane have been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, liver and pancreas, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Bile Duct Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 44Novoseek, 39NCIt, 57SNOMED-CT, 34MeSH
See all sources

Bile Duct Adenoma, Aliases & Descriptions:

Name: Bile Duct Adenoma 8 10 62
Adenoma Bile Duct 44
 
Cholangioadenoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology8 DOID:5381
NCIt39 C2942
MeSH34 D002759

Related Diseases for Bile Duct Adenoma

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Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.6SMAD4, TP63, AMACR, KRT7, KRT20, KRT19
2cholangiocarcinoma29.5KRT7, KRT20, TP53, SMAD4, ERBB2, KRT19
3adenocarcinoma28.7TP63, ERBB2, KRT19, MSLN, KRT20, AMACR
4intrahepatic bile duct adenoma10.8
5metanephric adenoma10.5KRT7
6extrahepatic bile duct adenoma10.5
7hepatitis10.5
8pancreatitis10.5
9syringoma10.4KRT19
10nephrogenic adenoma10.4AMACR, KRT7
11cholangitis10.4
12pseudomyxoma peritonei10.4KRT20, KRT7
13spindle cell sarcoma10.4DES, KRT7
14bladder adenocarcinoma10.4KRT20, KRT7
15signet ring cell adenocarcinoma10.4KRT7, KRT20
16ovarian brenner tumor10.4KRT20, KRT7
17sex cord-gonadal stromal tumor10.3KRT7, DES
18bronchiolo-alveolar adenocarcinoma10.3KRT20, KRT7
19cervical adenocarcinoma10.3KRT20, KRT7
20lipoma10.3DES, AMACR
21embryonal rhabdomyosarcoma10.3SMAD4, DES
22benign mesothelioma10.3TP53, MSLN
23bowen syndrome10.3KRT19, KRT7
24gallbladder cancer10.3SMAD4, KRT7
25hemangioma10.2
26cholangiolocellular carcinoma10.2
27acute cholangitis10.2
28choledochal cyst10.2
29angiomyolipoma10.2
30cavernous hemangioma10.2
31bladder transitional cell carcinoma10.2KRT20, TP53
32thymus cancer10.2KRT7, TP63
33ameloblastoma10.2KRT7, KRT19
34renal clear cell carcinoma10.2AMACR, KRT7
35gastrointestinal carcinoma10.2KRT20, KRT19
36abrikosov's tumor10.2KRT20, KRT7, DES
37wilms tumor10.2AMACR, KRT7, DES
38mucinous cystadenocarcinoma10.2KRT7, KRT20, SMAD4
39pancreatic ductal carcinoma10.2SMAD4, KRT20, KRT7
40uterine fibroid10.2DES, AMACR
41mucoepidermoid carcinoma10.2TP63, KRT7
42liposarcoma10.2TP53, DES
43kidney cancer10.2KRT7, AMACR, TP53
44chordoma10.2DES, KRT7, KRT19
45synovial sarcoma10.2DES, KRT7, KRT19
46actinic keratosis10.1TP53, TP63
47pancreatic cancer10.1KRT19, MSLN, SMAD4
48spindle cell carcinoma10.1DES, TP63, AMACR
49adrenocortical carcinoma10.1TP53, SMAD4
50biliary tract neoplasm10.1ERBB2, SMAD4

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to bile duct adenoma

Symptoms for Bile Duct Adenoma

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Drugs & Therapeutics for Bile Duct Adenoma

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Drug clinical trials:

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Search NIH Clinical Center for Bile Duct Adenoma

Genetic Tests for Bile Duct Adenoma

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Anatomical Context for Bile Duct Adenoma

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MalaCards organs/tissues related to Bile Duct Adenoma:

32
Liver, Pancreas

FMA organs/tissues related to Bile Duct Adenoma:

14
A fibrous stroma

Animal Models for Bile Duct Adenoma or affiliated genes

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Publications for Bile Duct Adenoma

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Articles related to Bile Duct Adenoma:

(show all 37)
idTitleAuthorsYear
1
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: Pathogenesis and histological characteristics. (25329860)
2014
2
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24843248)
2014
3
Cytopathologic, histopathologic, and immunohistochemical features of intrahepatic clear cell bile duct adenoma: a case report and review of the literature. (24955270)
2014
4
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. (24487593)
2014
5
Bile duct adenoma with oncocytic features. (24592348)
2014
6
Bile duct adenoma: a case report and literature review. (24767257)
2014
7
Intrahepatic bile duct adenoma with oncocytic features. (22891770)
2013
8
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. (23666160)
2013
9
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24043970)
2013
10
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. (24125022)
2013
11
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. (22933260)
2012
12
Incidental removal of distal common bile duct adenoma after plastic stent placement. (22396252)
2012
13
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. (23687608)
2012
14
A case of very large intrahepatic bile duct adenoma followed for 7 years. (22574289)
2012
15
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. (20808701)
2010
16
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. (20679879)
2010
17
Common bile duct adenoma: case report and brief review of literature. (21150400)
2010
18
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. (18417685)
2008
19
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
20
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. (16937485)
2006
21
Bile duct adenoma with oncocytic features. (16918984)
2006
22
Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. (15725808)
2005
23
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. (12603542)
2003
24
Acute cholangitis secondary to a common bile duct adenoma. (12845956)
2003
25
Bile duct adenoma: management by subtotal excision. (14603832)
2003
26
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. (12207078)
2002
27
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. (11766641)
2001
28
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. (11420469)
2001
29
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. (10524847)
1999
30
The so-called bile duct adenoma is a peribiliary gland hamartoma. (8669534)
1996
31
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. (8608764)
1995
32
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. (7757293)
1995
33
Bile duct adenoma. A study of 152 cases. (3046396)
1988
34
Bile duct adenoma. (2990370)
1985
35
The bile duct adenoma. A lesion distinct from Meyenburg complex. (6548370)
1984
36
Surgical importance of bile duct adenoma of liver. (13545501)
1958
37
Multiple bile duct adenoma. (20986272)
1946

Variations for Bile Duct Adenoma

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Expression for genes affiliated with Bile Duct Adenoma

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Expression patterns in normal tissues for genes affiliated with Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for genes affiliated with Bile Duct Adenoma

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Pathways related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, SMAD4
29.8TP53, SMAD4
3
Show member pathways
9.8TP53, TP63
49.6TP53, KRT19
59.5ERBB2, TP53, SMAD4
6
Show member pathways
9.5ERBB2, SMAD4, TP53
7
Show member pathways
Signal transduction PTEN pathway60
9.5ERBB2, SMAD4, TP53
89.5TP53, ERBB2, SMAD4
9
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.5SMAD4, TP53, ERBB2
109.4TP63, TP53, ERBB2
119.4KRT7, KRT19
129.1KRT19, KRT7, DES

Compounds for genes affiliated with Bile Duct Adenoma

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Compounds related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1ddp-cr4410.2ERBB2, AMACR
2taxane4410.0ERBB2, TP53
3noxa4410.0TP53, TP63
4reticulin4410.0KRT7, DES
5exotoxin-a4410.0ERBB2, MSLN
6radicicol44 61 1111.9TP53, ERBB2
7biotin44 24 1111.9ERBB2, AMACR, DES
8crcs449.9TP53, SMAD4
9guanine44 24 1111.8TP53, AMACR, ERBB2
10n-(4-hydroxyphenyl)retinamide449.8ERBB2, TP53
11p002449.7DES, ERBB2, KRT19
12bromodeoxyuridine449.7DES, TP63, KRT19
13p005449.5TP63, KRT19
14suberoylanilide hydroxamic acid449.5ERBB2, TP53
15lactate449.4DES, SMAD4, ERBB2, KRT19
16oligonucleotide449.3SMAD4, TP53, AMACR, MSLN
17adriamycin449.3KRT19, ERBB2, TP53, DES
18matrigel449.3KRT19, KRT7, TP63
19retinoid449.3TP53, KRT7, KRT19
20paclitaxel44 50 1111.2KRT19, ERBB2, TP53
21cisplatin44 50 61 1112.2KRT19, ERBB2, TP53, TP63
22streptavidin449.2KRT20, KRT7, AMACR, DES
23mucicarmine449.1DES, TP63, KRT7, KRT20
24steroid449.1DES, SMAD4, TP63, ERBB2, KRT19
25thymidine44 2410.0DES, SMAD4, TP63, TP53, KRT19
26hyaluronic acid44 2410.0KRT19, KRT20, MSLN, DES
27doxorubicin44 50 1110.9DES, TP63, TP53, ERBB2, KRT20
28glucose448.9DES, SMAD4, AMACR, KRT7, KRT19
29serine448.8DES, SMAD4, TP53, ERBB2, KRT19
30glutamate448.8TP63, AMACR, ERBB2, BDH1
31arginine448.7DES, SMAD4, TP63, TP53, ERBB2, KRT7
32iron44 249.6DES, SMAD4, KRT7, KRT20, KRT19
33formaldehyde44 249.6DES, ERBB2, KRT7, KRT20, KRT19
34retinoic acid44 249.6DES, TP63, TP53, AMACR, KRT7, KRT19
35hematoxylin448.4DES, TP63, AMACR, KRT7, KRT20, KRT19
36b 723448.2DES, TP63, MSLN, KRT7, KRT20, KRT19
37testosterone44 61 24 1110.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
38tyrosine447.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
39progesterone44 28 61 24 1111.6DES, TP63, TP53, AMACR, ERBB2, KRT7
40paraffin447.3KRT19, DES, SMAD4, TP63, TP53, AMACR
41vegf447.1DES, SMAD4, TP63, TP53, MSLN, ERBB2
42estrogen446.9DES, SMAD4, TP63, TP53, AMACR, MSLN

GO Terms for genes affiliated with Bile Duct Adenoma

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Cellular components related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.2DES, KRT7, KRT20, KRT19
2cytoplasmGO:0057377.3CYS1, SMAD4, TP63, TP53, AMACR, ERBB2

Biological processes related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP53, TP63
3response to X-rayGO:0101659.9TP53, TP63
4cell agingGO:0075699.8TP53, TP63
5response to gamma radiationGO:0103329.8TP63, TP53
6neuron apoptotic processGO:0514029.8TP53, TP63
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP53, TP63
8cellular response to UVGO:0346449.5TP53, TP63

Molecular functions related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.7SMAD4, TP53
2transcription regulatory region DNA bindingGO:0442129.5TP53, TP63, SMAD4
3damaged DNA bindingGO:0036849.5TP63, TP53
4chromatin bindingGO:0036829.5SMAD4, TP63, TP53
5structural constituent of cytoskeletonGO:0052009.1KRT19, KRT20, DES
6identical protein bindingGO:0428029.0ERBB2, DES, SMAD4, TP63, TP53
7protein bindingGO:0055156.5MSLN, KRT20, KRT7, ERBB2, TP53, TP63

Products for genes affiliated with Bile Duct Adenoma

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Sources for Bile Duct Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet