MCID: BLD033
MIFTS: 45

Bile Duct Adenoma malady

Liver diseases category

Summaries for Bile Duct Adenoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adenoma and biliary tract cancer that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards: Bile Duct Adenoma, also known as adenoma bile duct, is related to adenoma and pancreatitis. An important gene associated with Bile Duct Adenoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are TP53 network and Apoptosis Modulation and Signaling. The compounds adriamycin and ddp-cr have been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, liver and pancreas, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Bile Duct Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct adenoma 8 10 60
adenoma bile duct 44
cholangioadenoma 8


External Ids:

Disease Ontology8 DOID:5381
MeSH34 D002759
NCIt39 C2942

Related Diseases for Bile Duct Adenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.3AMACR, KRT19, KRT7, KRT20, SMAD4, TP63
2pancreatitis30.6SMAD4
3hepatitis30.5AMACR
4angiomyolipoma30.2DES
5cholangiocarcinoma30.2KRT19, KRT7, KRT20, ERBB2, SMAD4, TP53
6adenocarcinoma30.2AMACR, TFF2, KRT19, KRT7, KRT20, MSLN
7intrahepatic bile duct adenoma10.7
8extrahepatic bile duct adenoma10.4
9cholangitis10.3
10clear cell adenoma10.2
11acute pancreatitis10.2
12hemangioma of liver10.2
13choledochal cyst10.2
14acute cholangitis10.2
15hepatitis a10.2
16papillary adenoma10.2
17bile duct adenocarcinoma10.2
18cavernous hemangioma10.2
19hemangioma10.2
20mixed cell type cancer10.0KRT7
21metanephric adenoma10.0KRT7
22malignant pleural mesothelioma10.0MSLN
23teratoma10.0KRT7
24renal oncocytoma10.0KRT7
25sertoli cell tumor10.0DES
26cystadenoma10.0KRT7
27gastrointestinal stromal tumor10.0DES
28inverted papilloma10.0KRT20
29fibromatosis10.0DES
30pancreas disease10.0SMAD4
31rhabdoid tumor10.0DES
32syringoma10.0KRT19
33gallbladder cancer10.0TP53
34thymoma10.0TP63
35nephrogenic adenoma10.0AMACR, KRT7
36ulcerative colitis10.0TP53
37myoepithelioma10.0TP63
38nephroblastoma10.0TP53
39malignant fibroxanthoma10.0TP53
40leiomyoma10.0SMAD4, DES
41neuroblastoma10.0TP53
42seminoma10.0SMAD4
43leukemia10.0TP53
44renal clear cell carcinoma10.0KRT7, AMACR
45cervical adenocarcinoma10.0KRT20, KRT7
46spindle cell sarcoma10.0KRT7, DES
47intestinal neoplasm10.0KRT20, TFF2
48colon adenocarcinoma10.0SMAD4, KRT20
49gastritis10.0TP53, TFF2
50benign mesothelioma10.0MSLN, TP53

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to bile duct adenoma

Clinical Features for Bile Duct Adenoma

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Drugs & Therapeutics for Bile Duct Adenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Adenoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Adenoma

Search NIH Clinical Center for Bile Duct Adenoma

Search CenterWatch for Bile Duct Adenoma

Genetic Tests for Bile Duct Adenoma

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Anatomical Context for Bile Duct Adenoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Bile Duct Adenoma:

32
Liver, Pancreas

FMA organs/tissues related to Bile Duct Adenoma:

14
A fibrous stroma

Animal Models for Bile Duct Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bile Duct Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0AMACR, TFF2, DES, CYS1
2MP:00053798.8TFF2, CYS1, KRT19, TP53
3MP:00020068.8TP53, TP63, SMAD4, ERBB2, KRT19
4MP:00053678.3CYS1, KRT7, SMAD4, TP63, TP53
5MP:00028738.2KRT19, MSLN, ERBB2, SMAD4, TP63, TP53
6MP:00053817.9TP53, TP63, SMAD4, ERBB2, KRT19, CYS1
7MP:00107687.7DES, CYS1, KRT19, ERBB2, SMAD4, TP63

Publications for Bile Duct Adenoma

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50PubMed
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Articles related to Bile Duct Adenoma:

(show all 39)
idTitleAuthorsYear
1
Intrahepatic bile duct adenoma with oncocytic features. (22891770)
2013
2
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. (23666160)
2013
3
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24043970)
2013
4
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. (24125022)
2013
5
Non-invasive intraductal tubular adenoma, pyloric gland type, with malignant foci in the common bile duct. (23335071)
2013
6
Diagnostic value of HMGAs, p53 and I^-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. (23530587)
2013
7
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. (22933260)
2012
8
Incidental removal of distal common bile duct adenoma after plastic stent placement. (22396252)
2012
9
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. (23687608)
2012
10
A case of very large intrahepatic bile duct adenoma followed for 7 years. (22574289)
2012
11
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. (20808701)
2010
12
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. (20679879)
2010
13
Common bile duct adenoma: case report and brief review of literature. (21150400)
2010
14
Tubulovillous adenoma in the common bile duct causing obstructive jaundice. (20163042)
2009
15
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. (18417685)
2008
16
Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum. (18326932)
2008
17
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
18
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. (16937485)
2006
19
Bile duct adenoma with oncocytic features. (16918984)
2006
20
Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. (15725808)
2005
21
Common bile duct papillary adenoma causing obstructive jaundice: case report and review of the literature. (15156955)
2004
22
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. (12603542)
2003
23
Acute cholangitis secondary to a common bile duct adenoma. (12845956)
2003
24
Bile duct adenoma: management by subtotal excision. (14603832)
2003
25
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. (12207078)
2002
26
Papillary adenoma of the bile duct. (11375588)
2001
27
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. (11766641)
2001
28
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. (11420469)
2001
29
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. (10524847)
1999
30
Papillary adenoma of the distal common bile duct. (10452691)
1999
31
The so-called bile duct adenoma is a peribiliary gland hamartoma. (8669534)
1996
32
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. (8608764)
1995
33
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. (7757293)
1995
34
Bile duct adenoma. A study of 152 cases. (3046396)
1988
35
Obstruction of the bile duct by a papillary adenoma of the gallbladder. (3371852)
1988
36
Bile duct adenoma. (2990370)
1985
37
The bile duct adenoma. A lesion distinct from Meyenburg complex. (6548370)
1984
38
Surgical importance of bile duct adenoma of liver. (13545501)
1958
39
Multiple bile duct adenoma. (20986272)
1946

Genetic Variations for Bile Duct Adenoma

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Expression for genes affiliated with Bile Duct Adenoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for genes affiliated with Bile Duct Adenoma

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Sources:
37NCBI BioSystems Database, 59Tocris Bioscience, 29KEGG, 12EMD Millipore
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Pathways related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, TP63
2
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9.8TP53, TP63
3
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9.8TP53, ERBB2
4
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9.5TP53, SMAD4, ERBB2
5
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9.5TP53, SMAD4, ERBB2
6
Hide members
9.5ERBB2, SMAD4, TP53

Compounds for genes affiliated with Bile Duct Adenoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1adriamycin4410.5DES
2ddp-cr4410.2ERBB2, AMACR
3reticulin449.9KRT7, DES
4biotin44 11 2411.8AMACR, DES, ERBB2
5taxane449.8TP53, ERBB2
6p002449.5ERBB2, KRT19, DES
7exotoxin-a449.5ERBB2, MSLN
8bromodeoxyuridine449.5TP63, KRT19, DES
9lactate449.2DES, KRT19, ERBB2, SMAD4
10streptavidin449.0KRT20, KRT7, DES, AMACR
11thymidine44 2410.0DES, KRT19, SMAD4, TP63, TP53
12steroid449.0TP63, SMAD4, ERBB2, KRT19, DES
13cisplatin44 49 59 1112.0KRT19, ERBB2, TP63, TP53
14mucicarmine449.0DES, KRT7, KRT20, TP63
15glucose448.9AMACR, KRT19, KRT7, SMAD4
16arginine448.8DES, KRT7, ERBB2, SMAD4, TP63, TP53
17hyaluronic acid44 249.8MSLN, KRT20, KRT19, DES
18doxorubicin44 49 1110.7DES, KRT20, ERBB2, TP63, TP53
19retinoic acid44 249.6AMACR, DES, KRT19, KRT7, TP63, TP53
20formaldehyde44 249.4DES, KRT19, KRT7, KRT20, ERBB2
21iron44 249.4DES, KRT19, KRT7, KRT20, SMAD4
22hematoxylin448.2AMACR, DES, KRT19, KRT7, KRT20, TP63
23b 723448.1TP63, DES, KRT19, KRT7, KRT20, MSLN
24testosterone44 59 11 2410.6AMACR, DES, KRT19, KRT7, KRT20, ERBB2
25tyrosine447.6AMACR, DES, KRT19, KRT7, KRT20, ERBB2
26progesterone44 59 28 11 2411.5AMACR, DES, KRT19, KRT7, KRT20, ERBB2
27paraffin447.3AMACR, DES, KRT19, KRT7, KRT20, ERBB2
28vegf447.1DES, KRT19, KRT7, KRT20, MSLN, ERBB2

GO Terms for genes affiliated with Bile Duct Adenoma

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16Gene Ontology
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Cellular components related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.4KRT20, KRT7, KRT19, DES

Biological processes related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:0315719.9TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP53, TP63
3response to X-rayGO:0101659.8TP53, TP63
4response to gamma radiationGO:0103329.8TP53, TP63
5intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP63, TP53
6cell agingGO:0075699.5TP53, TP63

Molecular functions related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442129.5TP53, TP63, SMAD4
2identical protein bindingGO:0428028.9SMAD4, ERBB2, DES, TP53, TP63
3structural constituent of cytoskeletonGO:0052008.6KRT20, DES, KRT19
4protein bindingGO:0055155.9CYS1, TFF2, DES, KRT19, KRT7, KRT20

Products for genes affiliated with Bile Duct Adenoma

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Sources for Bile Duct Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet