MCID: BLD033
MIFTS: 41

Bile Duct Adenoma malady

Liver diseases category

Aliases & Classifications for Bile Duct Adenoma

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Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 55SNOMED-CT, 33MeSH, 38NCIt
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Bile Duct Adenoma, Aliases & Descriptions:

Name: Bile Duct Adenoma 9 11 60
Adenoma Bile Duct 43
 
Cholangioadenoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


External Ids:

Disease Ontology9 DOID:5381
MeSH33 D002759
NCIt38 C2942

Summaries for Bile Duct Adenoma

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Disease Ontology:9 An adenoma and biliary tract cancer that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards based summary: Bile Duct Adenoma, also known as adenoma bile duct, is related to adenoma and cholangiocarcinoma. An important gene associated with Bile Duct Adenoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Signal transduction JNK pathway and LKB1 signaling events. The compounds ddp-cr and taxane have been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, liver and pancreas, and related mouse phenotypes are muscle and tumorigenesis.

Related Diseases for Bile Duct Adenoma

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Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.6SMAD4, TP63, TP53, AMACR, KRT7, KRT20
2cholangiocarcinoma29.5SMAD4, TP53, ERBB2, KRT7, KRT20, KRT19
3adenocarcinoma28.7SMAD4, TP63, TP53, AMACR, MSLN, ERBB2
4intrahepatic bile duct adenoma10.8
5extrahepatic bile duct adenoma10.5
6metanephric adenoma10.5KRT7
7hepatitis10.5
8pancreatitis10.5
9syringoma10.4KRT19
10nephrogenic adenoma10.4AMACR, KRT7
11cholangitis10.4
12pseudomyxoma peritonei10.4KRT20, KRT7
13spindle cell sarcoma10.4KRT7, DES
14bladder adenocarcinoma10.4KRT20, KRT7
15ovarian brenner tumor10.3KRT20, KRT7
16signet ring cell adenocarcinoma10.3KRT20, KRT7
17sex cord-gonadal stromal tumor10.3DES, KRT7
18bronchiolo-alveolar adenocarcinoma10.3KRT7, KRT20
19cervical adenocarcinoma10.3KRT7, KRT20
20lipoma10.3DES, AMACR
21embryonal rhabdomyosarcoma10.3DES, SMAD4
22benign mesothelioma10.3TP53, MSLN
23bowen syndrome10.3KRT19, KRT7
24gallbladder cancer10.2KRT7, SMAD4
25hemangioma10.2
26cholangiolocellular carcinoma10.2
27choledochal cyst10.2
28acute cholangitis10.2
29angiomyolipoma10.2
30cavernous hemangioma10.2
31bladder transitional cell carcinoma10.2KRT20, TP53
32thymic carcinoma10.2KRT7, TP63
33ameloblastoma10.2KRT7, KRT19
34renal clear cell carcinoma10.2AMACR, KRT7
35gastrointestinal carcinoma10.2KRT20, KRT19
36abrikosov's tumor10.2KRT20, KRT7, DES
37wilms tumor10.2KRT7, AMACR, DES
38mucinous cystadenocarcinoma10.2KRT20, KRT7, SMAD4
39pancreatic ductal carcinoma10.2SMAD4, KRT7, KRT20
40uterine fibroid10.2DES, AMACR
41mucoepidermoid carcinoma10.2TP63, KRT7
42liposarcoma10.2DES, TP53
43renal cell carcinoma10.2KRT7, AMACR, TP53
44chordoma10.2DES, KRT7, KRT19
45sarcoma, synovial10.1KRT19, KRT7, DES
46actinic keratosis10.1TP63, TP53
47pancreatic cancer10.1SMAD4, MSLN, KRT19
48spindle cell carcinoma10.1AMACR, TP63, DES
49adrenocortical carcinoma10.1TP53, SMAD4
50biliary tract neoplasm10.1ERBB2, SMAD4

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to bile duct adenoma

Symptoms for Bile Duct Adenoma

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Drugs & Therapeutics for Bile Duct Adenoma

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Drug clinical trials:

Search ClinicalTrials for Bile Duct Adenoma

Search NIH Clinical Center for Bile Duct Adenoma

Genetic Tests for Bile Duct Adenoma

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Anatomical Context for Bile Duct Adenoma

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MalaCards organs/tissues related to Bile Duct Adenoma:

31
Liver, Pancreas

FMA organs/tissues related to Bile Duct Adenoma:

14
A fibrous stroma

Animal Models for Bile Duct Adenoma or affiliated genes

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Publications for Bile Duct Adenoma

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Articles related to Bile Duct Adenoma:

(show all 38)
idTitleAuthorsYear
1
Bile duct adenoma should not be designated as a reactive process. (25727261)
2015
2
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: Pathogenesis and histological characteristics. (25329860)
2014
3
RE: Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24843248)
2014
4
Cytopathologic, histopathologic, and immunohistochemical features of intrahepatic clear cell bile duct adenoma: a case report and review of the literature. (24955270)
2014
5
Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. (24487593)
2014
6
Bile duct adenoma with oncocytic features. (24592348)
2014
7
Bile duct adenoma: a case report and literature review. (24767257)
2014
8
Intrahepatic bile duct adenoma with oncocytic features. (22891770)
2013
9
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. (23666160)
2013
10
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24043970)
2013
11
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. (24125022)
2013
12
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. (22933260)
2012
13
Incidental removal of distal common bile duct adenoma after plastic stent placement. (22396252)
2012
14
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. (23687608)
2012
15
A case of very large intrahepatic bile duct adenoma followed for 7 years. (22574289)
2012
16
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. (20808701)
2010
17
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. (20679879)
2010
18
Common bile duct adenoma: case report and brief review of literature. (21150400)
2010
19
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. (18417685)
2008
20
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
21
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. (16937485)
2006
22
Bile duct adenoma with oncocytic features. (16918984)
2006
23
Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. (15725808)
2005
24
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. (12603542)
2003
25
Acute cholangitis secondary to a common bile duct adenoma. (12845956)
2003
26
Bile duct adenoma: management by subtotal excision. (14603832)
2003
27
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. (12207078)
2002
28
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. (11766641)
2001
29
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. (11420469)
2001
30
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. (10524847)
1999
31
The so-called bile duct adenoma is a peribiliary gland hamartoma. (8669534)
1996
32
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. (8608764)
1995
33
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. (7757293)
1995
34
Bile duct adenoma. A study of 152 cases. (3046396)
1988
35
Bile duct adenoma. (2990370)
1985
36
The bile duct adenoma. A lesion distinct from Meyenburg complex. (6548370)
1984
37
Surgical importance of bile duct adenoma of liver. (13545501)
1958
38
Multiple bile duct adenoma. (20986272)
1946

Variations for Bile Duct Adenoma

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Expression for genes affiliated with Bile Duct Adenoma

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Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for genes affiliated with Bile Duct Adenoma

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Pathways related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, SMAD4
29.8TP53, SMAD4
3
Show member pathways
9.8TP53, TP63
49.6KRT19, TP53
59.5ERBB2, TP53, SMAD4
6
Show member pathways
9.5ERBB2, TP53, SMAD4
7
Show member pathways
Signal transduction PTEN pathway58
9.5ERBB2, TP53, SMAD4
89.5ERBB2, TP53, SMAD4
9
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.5SMAD4, TP53, ERBB2
109.4TP63, TP53, ERBB2
119.4KRT19, KRT7
129.1DES, KRT7, KRT19

Compounds for genes affiliated with Bile Duct Adenoma

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Compounds related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1ddp-cr4310.2ERBB2, AMACR
2taxane4310.0ERBB2, TP53
3noxa4310.0TP53, TP63
4reticulin4310.0KRT7, DES
5exotoxin-a4310.0ERBB2, MSLN
6radicicol43 59 1211.9TP53, ERBB2
7biotin43 24 1211.9ERBB2, AMACR, DES
8crcs439.9TP53, SMAD4
9guanine43 24 1211.8TP53, AMACR, ERBB2
10n-(4-hydroxyphenyl)retinamide439.8ERBB2, TP53
11p002439.7DES, ERBB2, KRT19
12bromodeoxyuridine439.7DES, TP63, KRT19
13p005439.5TP63, KRT19
14suberoylanilide hydroxamic acid439.5ERBB2, TP53
15lactate439.4DES, SMAD4, ERBB2, KRT19
16oligonucleotide439.3SMAD4, TP53, AMACR, MSLN
17adriamycin439.3KRT19, ERBB2, TP53, DES
18matrigel439.3KRT19, KRT7, TP63
19retinoid439.3TP53, KRT7, KRT19
20paclitaxel43 49 1211.2KRT19, ERBB2, TP53
21cisplatin43 49 59 1212.2KRT19, ERBB2, TP53, TP63
22streptavidin439.2KRT20, KRT7, AMACR, DES
23mucicarmine439.1DES, TP63, KRT7, KRT20
24steroid439.1DES, SMAD4, TP63, ERBB2, KRT19
25thymidine43 2410.0DES, SMAD4, TP63, TP53, KRT19
26hyaluronic acid43 2410.0KRT19, KRT20, MSLN, DES
27doxorubicin43 49 1210.9DES, TP63, TP53, ERBB2, KRT20
28glucose438.9DES, SMAD4, AMACR, KRT7, KRT19
29serine438.8DES, SMAD4, TP53, ERBB2, KRT19
30glutamate438.8TP63, AMACR, ERBB2, BDH1
31arginine438.7DES, SMAD4, TP63, TP53, ERBB2, KRT7
32iron43 249.6DES, SMAD4, KRT7, KRT20, KRT19
33formaldehyde43 249.6DES, ERBB2, KRT7, KRT20, KRT19
34retinoic acid43 249.6DES, TP63, TP53, AMACR, KRT7, KRT19
35hematoxylin438.4DES, TP63, AMACR, KRT7, KRT20, KRT19
36b 723438.2DES, TP63, MSLN, KRT7, KRT20, KRT19
37testosterone43 59 24 1210.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
38tyrosine437.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
39progesterone43 28 59 24 1211.6DES, TP63, TP53, AMACR, ERBB2, KRT7
40paraffin437.3KRT19, DES, SMAD4, TP63, TP53, AMACR
41vegf437.1DES, SMAD4, TP63, TP53, MSLN, ERBB2
42estrogen436.9DES, SMAD4, TP63, TP53, AMACR, MSLN

GO Terms for genes affiliated with Bile Duct Adenoma

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Cellular components related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058828.2KRT19, KRT20, KRT7, DES
2cytoplasmGO:00057377.3SMAD4, TP63, TP53, AMACR, ERBB2, KRT7

Biological processes related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:003157110.0TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.9TP53, TP63
3response to X-rayGO:00101659.9TP53, TP63
4cell agingGO:00075699.8TP53, TP63
5response to gamma radiationGO:00103329.8TP63, TP53
6neuron apoptotic processGO:00514029.8TP53, TP63
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.7TP53, TP63
8cellular response to UVGO:00346449.5TP53, TP63

Molecular functions related to Bile Duct Adenoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:00010859.7TP53, SMAD4
2damaged DNA bindingGO:00036849.5TP53, TP63
3transcription regulatory region DNA bindingGO:00442129.5SMAD4, TP63, TP53
4chromatin bindingGO:00036829.5TP53, TP63, SMAD4
5structural constituent of cytoskeletonGO:00052009.1KRT19, KRT20, DES
6identical protein bindingGO:00428029.0DES, SMAD4, TP63, TP53, ERBB2
7protein bindingGO:00055156.5KRT19, DES, CYS1, SMAD4, KRT20, KRT7

Products for genes affiliated with Bile Duct Adenoma

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Sources for Bile Duct Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet