MCID: BLD033
MIFTS: 48

Bile Duct Adenoma malady

Cancer diseases, Liver diseases categories

Summaries for Bile Duct Adenoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 An adenoma and biliary tract cancer that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards: Bile Duct Adenoma, also known as adenoma bile duct, is related to adenoma and cholangiocarcinoma. An important gene associated with Bile Duct Adenoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Signal transduction JNK pathway and LKB1 signaling events. The compounds ddp-cr and taxane have been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, liver and pancreas, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Bile Duct Adenoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct adenoma 9 11 63
adenoma bile duct 46
cholangioadenoma 9


External Ids:

Disease Ontology9 DOID:5381
NCIt41 C2942
MeSH36 D002759

Related Diseases for Bile Duct Adenoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.2SMAD4, TP63, AMACR, KRT7, KRT20, KRT19
2cholangiocarcinoma30.1KRT7, KRT20, TP53, SMAD4, ERBB2, KRT19
3adenocarcinoma29.9TP63, ERBB2, KRT19, MSLN, KRT20, AMACR
4intrahepatic bile duct adenoma10.7
5extrahepatic bile duct adenoma10.5
6pancreatitis10.5
7cholangitis10.4
8hepatitis10.4
9choledochal cyst10.2
10acute cholangitis10.2
11angiomyolipoma10.2
12cavernous hemangioma10.2
13hemangioma10.2
14metanephric adenoma10.1KRT7
15syringoma10.1KRT19
16nephrogenic adenoma10.1AMACR, KRT7
17pseudomyxoma peritonei10.1KRT20, KRT7
18spindle cell sarcoma10.1DES, KRT7
19bladder adenocarcinoma10.1KRT20, KRT7
20signet ring cell adenocarcinoma10.1KRT7, KRT20
21ovarian brenner tumor10.1KRT20, KRT7
22sex cord-gonadal stromal tumor10.1KRT7, DES
23bronchiolo-alveolar adenocarcinoma10.1KRT20, KRT7
24cervical adenocarcinoma10.1KRT20, KRT7
25lipoma10.1DES, AMACR
26embryonal rhabdomyosarcoma10.1SMAD4, DES
27benign mesothelioma10.1TP53, MSLN
28bowen syndrome10.1KRT19, KRT7
29gallbladder cancer10.1SMAD4, KRT7
30bladder transitional cell carcinoma10.1KRT20, TP53
31thymus cancer10.1KRT7, TP63
32adenoameloblastoma10.1KRT7, KRT19
33renal clear cell carcinoma10.1AMACR, KRT7
34abrikosov's tumor10.0KRT20, KRT7, DES
35wilms tumor10.0AMACR, KRT7, DES
36mucinous cystadenocarcinoma10.0KRT7, KRT20, SMAD4
37pancreatic ductal carcinoma10.0SMAD4, KRT20, KRT7
38uterine fibroid10.0DES, AMACR
39mucoepidermoid carcinoma10.0TP63, KRT7
40liposarcoma10.0TP53, DES
41chordoma10.0DES, KRT7, KRT19
42kidney cancer10.0KRT7, AMACR, TP53
43synovial sarcoma10.0DES, KRT7, KRT19
44actinic keratosis10.0TP53, TP63
45spindle cell carcinoma10.0DES, TP63, AMACR
46pancreatic cancer10.0KRT19, MSLN, SMAD4
47adrenocortical carcinoma10.0TP53, SMAD4
48biliary tract neoplasm10.0ERBB2, SMAD4
49nasopharynx carcinoma10.0AMACR, SMAD4, TP53
50skin benign neoplasm10.0TP63, KRT20

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to bile duct adenoma

Symptoms for Bile Duct Adenoma

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Drugs & Therapeutics for Bile Duct Adenoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Adenoma

Drug clinical trials:

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Search NIH Clinical Center for Bile Duct Adenoma

Search CenterWatch for Bile Duct Adenoma

Genetic Tests for Bile Duct Adenoma

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Anatomical Context for Bile Duct Adenoma

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Bile Duct Adenoma:

34
Liver, Pancreas

FMA organs/tissues related to Bile Duct Adenoma:

15
A fibrous stroma

Animal Models for Bile Duct Adenoma or affiliated genes

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38MGI
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Publications for Bile Duct Adenoma

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53PubMed
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Articles related to Bile Duct Adenoma:

(show all 31)
idTitleAuthorsYear
1
Intrahepatic bile duct adenoma with oncocytic features. (22891770)
2013
2
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. (23666160)
2013
3
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24043970)
2013
4
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. (24125022)
2013
5
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. (22933260)
2012
6
Incidental removal of distal common bile duct adenoma after plastic stent placement. (22396252)
2012
7
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. (23687608)
2012
8
A case of very large intrahepatic bile duct adenoma followed for 7 years. (22574289)
2012
9
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. (20808701)
2010
10
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. (20679879)
2010
11
Common bile duct adenoma: case report and brief review of literature. (21150400)
2010
12
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. (18417685)
2008
13
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
14
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. (16937485)
2006
15
Bile duct adenoma with oncocytic features. (16918984)
2006
16
Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. (15725808)
2005
17
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. (12603542)
2003
18
Acute cholangitis secondary to a common bile duct adenoma. (12845956)
2003
19
Bile duct adenoma: management by subtotal excision. (14603832)
2003
20
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. (12207078)
2002
21
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. (11766641)
2001
22
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. (11420469)
2001
23
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. (10524847)
1999
24
The so-called bile duct adenoma is a peribiliary gland hamartoma. (8669534)
1996
25
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. (8608764)
1995
26
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. (7757293)
1995
27
Bile duct adenoma. A study of 152 cases. (3046396)
1988
28
Bile duct adenoma. (2990370)
1985
29
The bile duct adenoma. A lesion distinct from Meyenburg complex. (6548370)
1984
30
Surgical importance of bile duct adenoma of liver. (13545501)
1958
31
Multiple bile duct adenoma. (20986272)
1946

Variations for Bile Duct Adenoma

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Expression for genes affiliated with Bile Duct Adenoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for genes affiliated with Bile Duct Adenoma

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 5Cell Signaling Technology
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Pathways related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, SMAD4
29.8TP53, SMAD4
3
Show member pathways
9.8TP53, TP63
49.6KRT19, TP53
59.5ERBB2, TP53, SMAD4
6
Show member pathways
9.5ERBB2, TP53, SMAD4
7
Show member pathways
Signal transduction PTEN pathway61
9.5ERBB2, TP53, SMAD4
89.5ERBB2, TP53, SMAD4
9
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.5SMAD4, TP53, ERBB2
109.4TP63, TP53, ERBB2
119.4KRT19, KRT7
129.1DES, KRT7, KRT19

Compounds for genes affiliated with Bile Duct Adenoma

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1ddp-cr4610.2ERBB2, AMACR
2taxane4610.0ERBB2, TP53
3noxa4610.0TP53, TP63
4reticulin4610.0KRT7, DES
5exotoxin-a4610.0ERBB2, MSLN
6radicicol46 62 1211.9TP53, ERBB2
7biotin46 25 1211.9ERBB2, AMACR, DES
8crcs469.9TP53, SMAD4
9guanine46 25 1211.8TP53, AMACR, ERBB2
10n-(4-hydroxyphenyl)retinamide469.8ERBB2, TP53
11p002469.7DES, ERBB2, KRT19
12bromodeoxyuridine469.7DES, TP63, KRT19
13p005469.5TP63, KRT19
14suberoylanilide hydroxamic acid469.5ERBB2, TP53
15lactate469.4DES, SMAD4, ERBB2, KRT19
16oligonucleotide469.3SMAD4, TP53, AMACR, MSLN
17adriamycin469.3KRT19, ERBB2, TP53, DES
18matrigel469.3KRT19, KRT7, TP63
19retinoid469.3TP53, KRT7, KRT19
20paclitaxel46 52 1211.2KRT19, ERBB2, TP53
21cisplatin46 52 62 1212.2KRT19, ERBB2, TP53, TP63
22streptavidin469.2KRT20, KRT7, AMACR, DES
23mucicarmine469.1DES, TP63, KRT7, KRT20
24steroid469.1DES, SMAD4, TP63, ERBB2, KRT19
25thymidine46 2510.0DES, SMAD4, TP63, TP53, KRT19
26hyaluronic acid46 2510.0KRT19, KRT20, MSLN, DES
27doxorubicin46 52 1210.9DES, TP63, TP53, ERBB2, KRT20
28glucose468.9DES, SMAD4, AMACR, KRT7, KRT19
29serine468.8DES, SMAD4, TP53, ERBB2, KRT19
30glutamate468.8TP63, AMACR, ERBB2, BDH1
31arginine468.7DES, SMAD4, TP63, TP53, ERBB2, KRT7
32iron46 259.6DES, SMAD4, KRT7, KRT20, KRT19
33formaldehyde46 259.6DES, ERBB2, KRT7, KRT20, KRT19
34retinoic acid46 259.6DES, TP63, TP53, AMACR, KRT7, KRT19
35hematoxylin468.4DES, TP63, AMACR, KRT7, KRT20, KRT19
36b 723468.2DES, TP63, MSLN, KRT7, KRT20, KRT19
37testosterone46 62 25 1210.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
38tyrosine467.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
39progesterone46 30 62 25 1211.6DES, TP63, TP53, AMACR, ERBB2, KRT7
40paraffin467.3KRT19, DES, SMAD4, TP63, TP53, AMACR
41vegf467.1DES, SMAD4, TP63, TP53, MSLN, ERBB2
42estrogen466.9DES, SMAD4, TP63, TP53, AMACR, MSLN

GO Terms for genes affiliated with Bile Duct Adenoma

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17Gene Ontology
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Cellular components related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.2KRT19, KRT20, KRT7, DES
2cytoplasmGO:0057377.3SMAD4, TP63, TP53, AMACR, ERBB2, KRT7

Biological processes related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP53, TP63
3response to X-rayGO:0101659.9TP53, TP63
4cell agingGO:0075699.8TP53, TP63
5response to gamma radiationGO:0103329.8TP63, TP53
6neuron apoptotic processGO:0514029.8TP53, TP63
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP53, TP63
8cellular response to UVGO:0346449.5TP53, TP63

Molecular functions related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.7TP53, SMAD4
2damaged DNA bindingGO:0036849.5TP53, TP63
3transcription regulatory region DNA bindingGO:0442129.5SMAD4, TP63, TP53
4chromatin bindingGO:0036829.5TP53, TP63, SMAD4
5structural constituent of cytoskeletonGO:0052009.1KRT19, KRT20, DES
6identical protein bindingGO:0428029.0DES, SMAD4, TP63, TP53, ERBB2
7protein bindingGO:0055156.5KRT19, DES, CYS1, SMAD4, KRT20, KRT7

Products for genes affiliated with Bile Duct Adenoma

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  • Antibodies
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Sources for Bile Duct Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet