MCID: BLD033
MIFTS: 48

Bile Duct Adenoma malady

Cancer diseases, Liver diseases categories
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Summaries for Bile Duct Adenoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 An adenoma and biliary tract cancer that results in a small firm white nodule with multiple bile ducts that are located in a fibrous stroma.

MalaCards: Bile Duct Adenoma, also known as adenoma bile duct, is related to adenoma and cholangiocarcinoma. An important gene associated with Bile Duct Adenoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Signal transduction JNK pathway and LKB1 signaling events. The compounds ddp-cr and taxane have been mentioned in the context of this disorder. Affiliated tissues include a fibrous stroma, liver and pancreas, and related mouse phenotypes are muscle and tumorigenesis.

Aliases & Classifications for Bile Duct Adenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct adenoma 8 10 62
adenoma bile duct 45
cholangioadenoma 8


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Disease Ontology8 DOID:5381
NCIt40 C2942
MeSH35 D002759

Related Diseases for Bile Duct Adenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bile Duct Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.2SMAD4, TP63, AMACR, KRT7, KRT20, KRT19
2cholangiocarcinoma30.1KRT7, KRT20, TP53, SMAD4, ERBB2, KRT19
3adenocarcinoma29.9TP63, ERBB2, KRT19, MSLN, KRT20, AMACR
4intrahepatic bile duct adenoma10.7
5extrahepatic bile duct adenoma10.5
6pancreatitis10.5
7cholangitis10.4
8hepatitis10.4
9choledochal cyst10.2
10acute cholangitis10.2
11angiomyolipoma10.2
12cavernous hemangioma10.2
13hemangioma10.2
14metanephric adenoma10.1KRT7
15syringoma10.1KRT19
16nephrogenic adenoma10.1AMACR, KRT7
17pseudomyxoma peritonei10.1KRT20, KRT7
18spindle cell sarcoma10.1DES, KRT7
19bladder adenocarcinoma10.1KRT20, KRT7
20signet ring cell adenocarcinoma10.1KRT7, KRT20
21ovarian brenner tumor10.1KRT20, KRT7
22sex cord-gonadal stromal tumor10.1KRT7, DES
23bronchiolo-alveolar adenocarcinoma10.1KRT20, KRT7
24cervical adenocarcinoma10.1KRT20, KRT7
25lipoma10.1DES, AMACR
26embryonal rhabdomyosarcoma10.1SMAD4, DES
27benign mesothelioma10.1TP53, MSLN
28bowen syndrome10.1KRT19, KRT7
29gallbladder cancer10.1SMAD4, KRT7
30bladder transitional cell carcinoma10.1KRT20, TP53
31thymus cancer10.1KRT7, TP63
32adenoameloblastoma10.1KRT7, KRT19
33renal clear cell carcinoma10.1AMACR, KRT7
34abrikosov's tumor10.0KRT20, KRT7, DES
35wilms tumor10.0AMACR, KRT7, DES
36mucinous cystadenocarcinoma10.0KRT7, KRT20, SMAD4
37pancreatic ductal carcinoma10.0SMAD4, KRT20, KRT7
38uterine fibroid10.0DES, AMACR
39mucoepidermoid carcinoma10.0TP63, KRT7
40liposarcoma10.0TP53, DES
41chordoma10.0DES, KRT7, KRT19
42kidney cancer10.0KRT7, AMACR, TP53
43synovial sarcoma10.0DES, KRT7, KRT19
44actinic keratosis10.0TP53, TP63
45spindle cell carcinoma10.0DES, TP63, AMACR
46pancreatic cancer10.0KRT19, MSLN, SMAD4
47adrenocortical carcinoma10.0TP53, SMAD4
48biliary tract neoplasm10.0ERBB2, SMAD4
49nasopharynx carcinoma10.0AMACR, SMAD4, TP53
50skin benign neoplasm10.0TP63, KRT20

Graphical network of the top 20 diseases related to Bile Duct Adenoma:



Diseases related to bile duct adenoma

Symptoms for Bile Duct Adenoma

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Drugs & Therapeutics for Bile Duct Adenoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bile Duct Adenoma

Search NIH Clinical Center for Bile Duct Adenoma

Genetic Tests for Bile Duct Adenoma

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Anatomical Context for Bile Duct Adenoma

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Bile Duct Adenoma:

33
Liver, Pancreas

FMA organs/tissues related to Bile Duct Adenoma:

14
A fibrous stroma

Animal Models for Bile Duct Adenoma or affiliated genes

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37MGI
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Publications for Bile Duct Adenoma

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52PubMed
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Articles related to Bile Duct Adenoma:

(show all 31)
idTitleAuthorsYear
1
Intrahepatic bile duct adenoma with oncocytic features. (22891770)
2013
2
Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. (23666160)
2013
3
Diffusion-weighted MRI in intrahepatic bile duct adenoma arising from the cirrhotic liver. (24043970)
2013
4
Bile duct adenoma (hamartoma of peribiliary glands): Importance of an adequate diagnosis. (24125022)
2013
5
Bile duct adenoma causing recurrent cholangitis: diagnosis and management with targeted Spyglass access and radiofrequency ablation. (22933260)
2012
6
Incidental removal of distal common bile duct adenoma after plastic stent placement. (22396252)
2012
7
A combination of snare polypectomy and apc therapy for prolapsing common bile duct adenoma. (23687608)
2012
8
A case of very large intrahepatic bile duct adenoma followed for 7 years. (22574289)
2012
9
Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. (20808701)
2010
10
An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. (20679879)
2010
11
Common bile duct adenoma: case report and brief review of literature. (21150400)
2010
12
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. (18417685)
2008
13
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
14
Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. (16937485)
2006
15
Bile duct adenoma with oncocytic features. (16918984)
2006
16
Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. (15725808)
2005
17
Extra-hepatic bile duct adenoma in a patient with a choledochal cyst. (12603542)
2003
18
Acute cholangitis secondary to a common bile duct adenoma. (12845956)
2003
19
Bile duct adenoma: management by subtotal excision. (14603832)
2003
20
Mucin-secreting bile duct adenoma--clinicopathological resemblance to intraductal papillary mucinous tumor of the pancreas. (12207078)
2002
21
Concomitant occurrence of angiomyolipoma, focal nodular hyperplasia, bile duct adenoma, and cavernous hemangioma in the liver]. (11766641)
2001
22
Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. (11420469)
2001
23
Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. (10524847)
1999
24
The so-called bile duct adenoma is a peribiliary gland hamartoma. (8669534)
1996
25
Incarcerated bile duct adenoma as a rare cause of acute cholestatic pancreatitis. (8608764)
1995
26
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. (7757293)
1995
27
Bile duct adenoma. A study of 152 cases. (3046396)
1988
28
Bile duct adenoma. (2990370)
1985
29
The bile duct adenoma. A lesion distinct from Meyenburg complex. (6548370)
1984
30
Surgical importance of bile duct adenoma of liver. (13545501)
1958
31
Multiple bile duct adenoma. (20986272)
1946

Variations for Bile Duct Adenoma

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Expression for genes affiliated with Bile Duct Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Adenoma

Search GEO for disease gene expression data for Bile Duct Adenoma.

Pathways for genes affiliated with Bile Duct Adenoma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 5Cell Signaling Technology
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Pathways related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TP53, SMAD4
29.8TP53, SMAD4
3
Show member pathways
9.8TP53, TP63
49.6KRT19, TP53
59.5ERBB2, TP53, SMAD4
6
Show member pathways
9.5ERBB2, TP53, SMAD4
7
Show member pathways
Signal transduction PTEN pathway60
9.5ERBB2, TP53, SMAD4
89.5ERBB2, TP53, SMAD4
9
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.5SMAD4, TP53, ERBB2
109.4TP63, TP53, ERBB2
119.4KRT19, KRT7
129.1DES, KRT7, KRT19

Compounds for genes affiliated with Bile Duct Adenoma

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45Novoseek, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1ddp-cr4510.2ERBB2, AMACR
2taxane4510.0ERBB2, TP53
3noxa4510.0TP53, TP63
4reticulin4510.0KRT7, DES
5exotoxin-a4510.0ERBB2, MSLN
6radicicol45 61 1111.9TP53, ERBB2
7biotin45 24 1111.9ERBB2, AMACR, DES
8crcs459.9TP53, SMAD4
9guanine45 24 1111.8TP53, AMACR, ERBB2
10n-(4-hydroxyphenyl)retinamide459.8ERBB2, TP53
11p002459.7DES, ERBB2, KRT19
12bromodeoxyuridine459.7DES, TP63, KRT19
13p005459.5TP63, KRT19
14suberoylanilide hydroxamic acid459.5ERBB2, TP53
15lactate459.4DES, SMAD4, ERBB2, KRT19
16oligonucleotide459.3SMAD4, TP53, AMACR, MSLN
17adriamycin459.3KRT19, ERBB2, TP53, DES
18matrigel459.3KRT19, KRT7, TP63
19retinoid459.3TP53, KRT7, KRT19
20paclitaxel45 51 1111.2KRT19, ERBB2, TP53
21cisplatin45 51 61 1112.2KRT19, ERBB2, TP53, TP63
22streptavidin459.2KRT20, KRT7, AMACR, DES
23mucicarmine459.1DES, TP63, KRT7, KRT20
24steroid459.1DES, SMAD4, TP63, ERBB2, KRT19
25thymidine45 2410.0DES, SMAD4, TP63, TP53, KRT19
26hyaluronic acid45 2410.0KRT19, KRT20, MSLN, DES
27doxorubicin45 51 1110.9DES, TP63, TP53, ERBB2, KRT20
28glucose458.9DES, SMAD4, AMACR, KRT7, KRT19
29serine458.8DES, SMAD4, TP53, ERBB2, KRT19
30glutamate458.8TP63, AMACR, ERBB2, BDH1
31arginine458.7DES, SMAD4, TP63, TP53, ERBB2, KRT7
32iron45 249.6DES, SMAD4, KRT7, KRT20, KRT19
33formaldehyde45 249.6DES, ERBB2, KRT7, KRT20, KRT19
34retinoic acid45 249.6DES, TP63, TP53, AMACR, KRT7, KRT19
35hematoxylin458.4DES, TP63, AMACR, KRT7, KRT20, KRT19
36b 723458.2DES, TP63, MSLN, KRT7, KRT20, KRT19
37testosterone45 61 24 1110.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
38tyrosine457.7DES, SMAD4, TP63, AMACR, ERBB2, KRT7
39progesterone45 29 61 24 1111.6DES, TP63, TP53, AMACR, ERBB2, KRT7
40paraffin457.3KRT19, DES, SMAD4, TP63, TP53, AMACR
41vegf457.1DES, SMAD4, TP63, TP53, MSLN, ERBB2
42estrogen456.9DES, SMAD4, TP63, TP53, AMACR, MSLN

GO Terms for genes affiliated with Bile Duct Adenoma

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16Gene Ontology
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Cellular components related to Bile Duct Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.2KRT19, KRT20, KRT7, DES
2cytoplasmGO:0057377.3SMAD4, TP63, TP53, AMACR, ERBB2, KRT7

Biological processes related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9TP53, TP63
3response to X-rayGO:0101659.9TP53, TP63
4cell agingGO:0075699.8TP53, TP63
5response to gamma radiationGO:0103329.8TP63, TP53
6neuron apoptotic processGO:0514029.8TP53, TP63
7intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.7TP53, TP63
8cellular response to UVGO:0346449.5TP53, TP63

Molecular functions related to Bile Duct Adenoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor bindingGO:0010859.7TP53, SMAD4
2damaged DNA bindingGO:0036849.5TP53, TP63
3transcription regulatory region DNA bindingGO:0442129.5SMAD4, TP63, TP53
4chromatin bindingGO:0036829.5TP53, TP63, SMAD4
5structural constituent of cytoskeletonGO:0052009.1KRT19, KRT20, DES
6identical protein bindingGO:0428029.0DES, SMAD4, TP63, TP53, ERBB2
7protein bindingGO:0055156.5KRT19, DES, CYS1, SMAD4, KRT20, KRT7

Products for genes affiliated with Bile Duct Adenoma

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  • Antibodies
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Sources for Bile Duct Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet