MCID: BLD034
MIFTS: 52

Bile Duct Carcinoma malady

Cancer diseases, Liver diseases categories

Summaries for Bile Duct Carcinoma

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards: Bile Duct Carcinoma, also known as bile duct cancer, is related to gallbladder cancer and cholangiocarcinoma. An important gene associated with Bile Duct Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Class C/3 (Metabotropic glutamate/pheromone receptors) and O-linked glycosylation of mucins. The compounds aspartame and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and skin, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that starts in the bile duct.

Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

Aliases & Classifications for Bile Duct Carcinoma

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8Disease Ontology, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 33MedlinePlus, 10DISEASES, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct carcinoma 8 60
bile duct cancer 42 44 33
carcinoma of extrahepatic bile duct 60
extrahepatic bile duct carcinoma 10
bile duct extrahepatic carcinoma 44
extrahepatic bile duct cancer 42


External Ids:

Disease Ontology8 DOID:4897
MeSH34 D001650
SNOMED-CT56 70179006
NCIt39 C27814
ICD1025 C24.0

Related Diseases for Bile Duct Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Bile Duct Carcinoma family:

Common Bile Duct Neoplasm Bile Duct Carcinoma in Situ

Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.8MUC2, CDX2
2cholangiocarcinoma30.5EBAG9, MUC2, CDX2, SLPI
3adenocarcinoma30.5FSCN1, SYP, EBAG9, MUC2, CDKN1C, MUC6
4neuroendocrine carcinoma30.2FSCN1, SYP, CDX2
5hepatocellular carcinoma30.2MGAT3, EBAG9, MUC2, CDX2, CDKN1C
6pancreatic cancer30.2MUC2, MUC6, CDX2, SYP
7hepatitis10.7
8ulcerative colitis10.6
9cholangitis10.6
10bile duct carcinoma in situ10.5
11adenosquamous carcinoma10.5
12sclerosing cholangitis10.4
13adenosquamous bile duct carcinoma10.4
14squamous cell bile duct carcinoma10.4
15bile duct adenocarcinoma10.4
16bile duct disease10.4
17in situ carcinoma10.4
18small cell carcinoma10.3
19obstructive jaundice10.3
20extrahepatic bile duct small cell adenocarcinoma10.3
21klatskin's tumor10.3
22bladder carcinoma10.3
23extrahepatic bile duct adenocarcinoma10.3
24pancreatitis10.3
25bone carcinoma10.1
26cholecystolithiasis10.1
27liver carcinoma in situ10.1
28portal vein thrombosis10.1
29choledocholithiasis10.1
30situs inversus10.1
31hepatitis b10.1
32choledochal cyst10.1
33alpha 1-antitrypsin deficiency10.1
34hepatitis a10.1
35gastric adenocarcinoma10.1
36intrahepatic cholangiocarcinoma10.1
37liver disease10.1
38neuroma10.1
39peritonitis10.1
40retinoblastoma10.1
41sarcoidosis10.1
42viral hepatitis10.1
43congenital hepatic fibrosis10.1
44common bile duct neoplasm10.1
45mucinous adenocarcinoma10.1
46bile duct mucinous adenocarcinoma10.1
47gallbladder adenocarcinoma10.1
48lymph node cancer10.1
49lynch syndrome10.1
50esophagitis10.0CDX2

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Clinical Features for Bile Duct Carcinoma

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Drugs & Therapeutics for Bile Duct Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Search CenterWatch for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

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Anatomical Context for Bile Duct Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Bile Duct Carcinoma:

32
Liver, Small intestine, Skin, Pancreas, Lymph node, Bone, Brain, Colon, Lung

Animal Models for Bile Duct Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bile Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.3TAS1R1, TAS1R2, TAS1R3
2MP:000537910.0SDC1, GALNT3, POSTN, MUC2, CDX2, CDKN1C
3MP:00020069.9MGAT3, POSTN, MUC2, CDX2, CEBPB, SDC1
4MP:00053899.8GALNT3, CDX2, CDKN1C, TAS1R1, CEBPB
5MP:00053849.7MGAT3, POSTN, MUC2, CDX2, CDKN1C, TAS1R1

Publications for Bile Duct Carcinoma

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50PubMed
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Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 351)
idTitleAuthorsYear
1
Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review. (23901240)
2013
2
Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma. (24102845)
2013
3
Multimodal treatment of hepatic metastasis in the form of a bile duct tumor thrombus from pancreatic acinar cell carcinoma: case report of successful resection after chemoradiation therapy. (22949891)
2012
4
Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. (20185162)
2010
5
Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma. (19521656)
2010
6
67-kDa laminin receptor in human bile duct carcinoma. (19182490)
2009
7
Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features. (18204917)
2009
8
Port-site metastasis of extrahepatic bile duct carcinoma after laparoscopic cholecystectomy without evidence of a primary tumour. (19241938)
2008
9
Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-. (17361208)
2007
10
Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts. (16984622)
2006
11
The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. (16525641)
2006
12
Neuroendocrine differentiation in extrahepatic bile duct carcinomas and its prognostic significance. (16084941)
2005
13
Anicteric early bile duct carcinoma detection with magnetic resonance cholangiopancreatography. (15816438)
2005
14
Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics. (15138129)
2004
15
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma. (15238704)
2004
16
Multiple stenting in hilar bile duct carcinoma: three-branched partial stent-in-stent deployment with the JOSTENT SelfX. (15326581)
2004
17
Primary bile duct carcinoma in histocompatibility antigen-identical twins. (12653905)
2003
18
One-step insertion of an expandable metallic stent for unresectable common bile duct carcinoma. (12802381)
2003
19
Expression of bile duct-type cytokeratin in noncancerous hepatocytes in patients with hepatitis B virus-related hepatocellular carcinoma. (12845990)
2003
20
Expression of Fas and induction of apoptosis by anti-Fas monoclonal antibody in human bile duct carcinoma cells, and enhancement of induction of apoptosis by IFN-gamma]. (12484048)
2002
21
Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma. (12378647)
2002
22
Critical role of type IV collagens in the growth of bile duct carcinoma. In vivo and in vitro studies. (11569922)
2001
23
Mutated SEA-D227A-conjugated antibodies greatly enhance antitumor activity against MUC1-expressing bile duct carcinoma. (11776376)
2001
24
Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma. (10707878)
2000
25
Surgical treatment and postoperative outcomes for middle and lower bile duct carcinoma in Japan--experience of a single institute. (10919005)
2000
26
Diagnosis and non-surgical treatment of bile duct carcinoma: developments in the past decade. (10832665)
2000
27
Limitation of cholangiography in assessing longitudinal spread of extrahepatic bile duct carcinoma to the hepatic side. (10440214)
1999
28
Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis. (10502315)
1999
29
Prognosis and treatment of bile duct carcinoma. (9764692)
1998
30
Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma. (9869516)
1998
31
Adenosquamous carcinoma of the bile duct: cytologic features of brush specimens from two cases. (8982588)
1996
32
Case of bile duct carcinoma of the hepatic hilus with segmental obstructive cholangitis. (8751205)
1995
33
Clear cell carcinomas of the gallbladder and extrahepatic bile ducts. (7802141)
1995
34
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1. (8693487)
1995
35
Three synchronous carcinomas of the papilla of Vater, common bile duct and pancreas. (8044300)
1994
36
Cholesterosis in bile duct carcinoma. (8163149)
1994
37
An immunohistochemical study of p53 protein in gallbladder and extrahepatic bile duct/ampullary carcinomas. (7520348)
1994
38
Synchronous carcinoma of the gall-bladder in patients with bile duct carcinoma. (8031336)
1993
39
Definitive postoperative irradiation of bile duct carcinoma with charged particles and/or photons. (8365945)
1993
40
Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. (1312319)
1992
41
Bile duct carcinoma in Egypt: possible etiological factors. (1657750)
1991
42
Diagnostic value of brush cytology in the diagnosis of bile duct carcinoma: a study in 65 patients with bile duct strictures. (2210678)
1990
43
The development and extension of hepatohilar bile duct carcinoma. A three-dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system. (2545324)
1989
44
The infiltration of bile duct carcinoma along the bile duct wall. (2840410)
1988
45
Bile duct carcinoma associated with multiple von Meyenburg complexes in the liver. (3793090)
1986
46
A palliative percutaneous drainage procedure for proximal bile duct carcinoma. (6203054)
1984
47
Canine bile duct carcinoma. (6266117)
1981
48
Bile duct carcinoma in dogs. (986381)
1976
49
Bile duct carcinoma associated with ulcerative colitis. (940978)
1976
50
Bile duct carcinoma in a goat, with metastasis in the lungs. (4311235)
1969

Genetic Variations for Bile Duct Carcinoma

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Expression for genes affiliated with Bile Duct Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

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53Reactome, 29KEGG
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Pathways related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3TAS1R1, TAS1R2, TAS1R3
2
Hide members
10.3MUC6, MUC2, GALNT3

Compounds for genes affiliated with Bile Duct Carcinoma

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame44 11 2412.5TAS1R2, TAS1R3
2hematoxylin4410.3SYP, MUC2, SLPI
3paraffin4410.3FSCN1, CDX2, MUC6, MUC2, SYP
4oligonucleotide4410.1CEBPB, SLPI, CDX2, MUC6, MUC2
5progesterone44 59 28 11 2414.0SYP, MUC2, MUC6, CDX2, CEBPB
6retinoic acid44 2411.0MGAT3, SYP, MUC2, FSCN1, SLPI, CEBPB
7calcium44 49 11 2412.9GALNT3, SYP, POSTN, MUC2, MUC6, CDX2
8cholesterol44 28 11 2412.8SYP, MUC2, MUC6, CDKN1C, SLPI

GO Terms for genes affiliated with Bile Duct Carcinoma

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16Gene Ontology
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Cellular components related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.3SDC1, MUC6, MUC2

Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1detection of chemical stimulus involved in sensory perception of sweet tasteGO:00158210.4TAS1R2, TAS1R3
2sensory perception of umami tasteGO:05091710.4TAS1R1, TAS1R3
3post-translational protein modificationGO:04368710.2MUC6, MUC2, MGAT3, GALNT3
4O-glycan processingGO:01626610.2GALNT3, MUC2, MUC6
5sensory perception of sweet tasteGO:05091610.1TAS1R2, TAS1R3

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.2CEBPB, TAS1R1, TAS1R2, TAS1R3
2taste receptor activityGO:00852710.2TAS1R1, TAS1R2, TAS1R3
3sweet taste receptor activityGO:03304110.1TAS1R2, TAS1R3

Products for genes affiliated with Bile Duct Carcinoma

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  • Antibodies
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Sources for Bile Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet