MCID: BLD034
MIFTS: 52

Bile Duct Carcinoma malady

Cancer diseases, Liver diseases categories

Summaries for Bile Duct Carcinoma

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards: Bile Duct Carcinoma, also known as bile duct cancer, is related to gallbladder cancer and cholangiocarcinoma. An important gene associated with Bile Duct Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Class C/3 (Metabotropic glutamate/pheromone receptors) and O-linked glycosylation of mucins. The compounds aspartame and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and skin, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that starts in the bile duct.

Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

Aliases & Classifications for Bile Duct Carcinoma

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8Disease Ontology, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 33MedlinePlus, 10DISEASES, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct carcinoma 8 60
bile duct cancer 42 44 33
carcinoma of extrahepatic bile duct 60
extrahepatic bile duct carcinoma 10
bile duct extrahepatic carcinoma 44
extrahepatic bile duct cancer 42


External Ids:

Disease Ontology8 DOID:4897
MeSH34 D001650
SNOMED-CT56 70179006
NCIt39 C27814
ICD1025 C24.0

Related Diseases for Bile Duct Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Bile Duct Carcinoma family:

Common Bile Duct Neoplasm Bile Duct Carcinoma in Situ

Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.8MUC2, CDX2
2cholangiocarcinoma30.5EBAG9, MUC2, CDX2, SLPI
3adenocarcinoma30.5FSCN1, SYP, EBAG9, MUC2, CDKN1C, MUC6
4neuroendocrine carcinoma30.2FSCN1, SYP, CDX2
5hepatocellular carcinoma30.2MGAT3, EBAG9, MUC2, CDX2, CDKN1C
6pancreatic cancer30.2MUC2, MUC6, CDX2, SYP
7hepatitis10.7
8ulcerative colitis10.6
9cholangitis10.6
10bile duct carcinoma in situ10.5
11adenosquamous carcinoma10.5
12sclerosing cholangitis10.4
13adenosquamous bile duct carcinoma10.4
14squamous cell bile duct carcinoma10.4
15bile duct adenocarcinoma10.4
16bile duct disease10.4
17in situ carcinoma10.4
18small cell carcinoma10.3
19obstructive jaundice10.3
20extrahepatic bile duct small cell adenocarcinoma10.3
21klatskin's tumor10.3
22bladder carcinoma10.3
23extrahepatic bile duct adenocarcinoma10.3
24pancreatitis10.3
25bone carcinoma10.1
26cholecystolithiasis10.1
27liver carcinoma in situ10.1
28portal vein thrombosis10.1
29choledocholithiasis10.1
30situs inversus10.1
31hepatitis b10.1
32choledochal cyst10.1
33alpha 1-antitrypsin deficiency10.1
34hepatitis a10.1
35gastric adenocarcinoma10.1
36intrahepatic cholangiocarcinoma10.1
37liver disease10.1
38neuroma10.1
39peritonitis10.1
40retinoblastoma10.1
41sarcoidosis10.1
42viral hepatitis10.1
43congenital hepatic fibrosis10.1
44common bile duct neoplasm10.1
45mucinous adenocarcinoma10.1
46bile duct mucinous adenocarcinoma10.1
47gallbladder adenocarcinoma10.1
48lymph node cancer10.1
49lynch syndrome10.1
50esophagitis10.0CDX2

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Clinical Features for Bile Duct Carcinoma

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Drugs & Therapeutics for Bile Duct Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Search CenterWatch for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

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Anatomical Context for Bile Duct Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Bile Duct Carcinoma:

32
Liver, Small intestine, Skin, Pancreas, Lymph node, Bone, Brain, Colon, Lung

Animal Models for Bile Duct Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bile Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.3TAS1R1, TAS1R2, TAS1R3
2MP:000537910.0SDC1, GALNT3, POSTN, MUC2, CDX2, CDKN1C
3MP:00020069.9MGAT3, POSTN, MUC2, CDX2, CEBPB, SDC1
4MP:00053899.8GALNT3, CDX2, CDKN1C, TAS1R1, CEBPB
5MP:00053849.7MGAT3, POSTN, MUC2, CDX2, CDKN1C, TAS1R1

Publications for Bile Duct Carcinoma

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Sources:
50PubMed
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Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 351)
idTitleAuthorsYear
1
Descriptive epidemiology of bile duct carcinoma in Osaka. (24014885)
2013
2
Down-regulation of c-Myc expression inhibits the invasion of bile duct carcinoma cells. (21557726)
2011
3
Three-dimensional cholangiography applying C-arm computed tomography in bile duct carcinoma: a new radiological technique. (19621666)
2009
4
Primary tumor/vessel tumor/nodal tumor classification of extrahepatic bile duct carcinoma. (17900657)
2008
5
Adenosquamous carcinoma of extrahepatic bile duct: clinicopathologic study of 12 cases. (18784802)
2008
6
p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance. (17385050)
2007
7
Impact of lymph node micrometastasis in hilar bile duct carcinoma patients. (16688800)
2006
8
A case of peribiliary cysts accompanying bile duct carcinoma. (16874882)
2006
9
Expression of PPAR-gamma in human hilar bile duct carcinoma cell line QBC939 and the effects of PPAR-Y activated by its ligand on the growth of QBC939]. (17037742)
2006
10
Combined total hepatectomy, orthotopic liver transplantation and pancreatoduodenectomy for unresectable hilar bile duct carcinoma]. (16635386)
2006
11
Early bile duct carcinoma: comparison of imaging features with pathologic findings. (16396837)
2006
12
Numerical Calculations of Heating Patterns around a Coaxial-Slot Antenna for Microwave Hyperthermia - Aiming at Treatment of Brain Tumor and Bile Duct Carcinoma-. (17282220)
2005
13
CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma. (16191504)
2005
14
A resected case of a small hepatocellular carcinoma developing within the bile duct. (15235893)
2004
15
Diagnostic and surgical therapeutic features of extrahepatic bile duct carcinoma without jaundice. (15378794)
2004
16
Sarcomatoid carcinoma of common bile duct: a case report. (15011841)
2004
17
Patterns and relevant factors of tumor recurrence for extrahepatic bile duct carcinoma after radical resection. (15532789)
2004
18
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response. (14756433)
2003
19
Intraluminal low-dose-rate 192Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable extrahepatic bile duct carcinoma. (14630274)
2003
20
Annular pancreas complicated by carcinoma of the bile duct: diagnosis by MR cholangiopancreatography and endoscopic ultrasonography. (12719909)
2003
21
Palliative treatment for bile duct carcinoma. (12828049)
2003
22
Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. (11283934)
2001
23
Abnormal distribution of collagen type IV in extrahepatic bile duct carcinoma. (11107064)
2000
24
Expression and clinical implications of bcl-2 in extrahepatic bile duct carcinoma: its relationship with biological features. (11268472)
2000
25
Undifferentiated spindle cell carcinoma of the extrahepatic bile ducts: a case report. (11100321)
2000
26
Liver regeneration after extended right hemihepatectomy in patients with hilar or diffuse bile duct carcinoma. (10228823)
1999
27
Long-term survival after resection of proximal bile duct carcinoma (Klatskin tumors). (9841770)
1999
28
Obstructive jaundice caused by lymphangitis carcinomatosa of bile duct wall from gastric carcinoma. (9516509)
1998
29
Multiple early bile duct carcinoma associated with congenital choledochal cyst. (9658331)
1998
30
Establishment and characterization of a new human extrahepatic bile duct carcinoma cell line (ICBD-1). (9468580)
1998
31
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma. (9369143)
1997
32
Bile duct carcinoma without jaundice: clues to early diagnosis. (9356876)
1997
33
Bile duct carcinoma arising from the anastomotic site of hepaticojejunostomy after the excision of congenital biliary dilatation: a case report. (8644016)
1996
34
Intraluminal brachytherapy in the treatment of pancreas and bile duct carcinoma. (7538501)
1995
35
Synchronous carcinoma of the gall-bladder in patients with bile duct carcinoma. (8147784)
1994
36
Establishment and characterization of a new human extrahepatic bile duct carcinoma cell line (KMBC). (1312890)
1992
37
Surgical treatment of hilar bile duct carcinoma. Clinical and pathological studies. (1458965)
1992
38
Evaluation of immunoreactivity to erbB-2 protein as a marker of prognosis in bile duct carcinoma]. (1361658)
1992
39
Radiotherapy of postoperative residual tumor of bile duct carcinoma. (1658858)
1991
40
Radiotherapy of bile duct carcinoma using intracatheter 198Au grains. (1658857)
1991
41
Bile duct carcinoma in the elderly. A rationale for surgical management. (1929819)
1991
42
Current status in the management of proximal bile duct carcinoma. (3013639)
1986
43
Bile duct carcinoma. Diagnosis and treatment. (2990361)
1985
44
Anomalous pancreaticobiliary duct union associated with bile duct carcinoma. (6724239)
1984
45
Operative results of extrahepatic bile duct carcinoma. (6290727)
1982
46
Bile duct carcinoma: a late complication of congenital hepatic fibrosis. Case report and review of literature. (6249119)
1980
47
Carcinoma arising in the wall of congenital bile duct cysts. (383269)
1979
48
Intrahepatic bile duct carcinoma with metastasis to bone in a dog. (919241)
1977
49
Gallbladder and extrahepatic bile duct carcinoma. Analysis of 1,808 cases. (5080807)
1972
50
Thorium dioxide angiography causing bile duct carcinoma; a case report with radiological studies. (4311203)
1969

Genetic Variations for Bile Duct Carcinoma

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Expression for genes affiliated with Bile Duct Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

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53Reactome, 29KEGG
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Pathways related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3TAS1R1, TAS1R2, TAS1R3
2
Hide members
10.3MUC6, MUC2, GALNT3

Compounds for genes affiliated with Bile Duct Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame44 11 2412.5TAS1R2, TAS1R3
2hematoxylin4410.3SYP, MUC2, SLPI
3paraffin4410.3FSCN1, CDX2, MUC6, MUC2, SYP
4oligonucleotide4410.1CEBPB, SLPI, CDX2, MUC6, MUC2
5progesterone44 59 28 11 2414.0SYP, MUC2, MUC6, CDX2, CEBPB
6retinoic acid44 2411.0MGAT3, SYP, MUC2, FSCN1, SLPI, CEBPB
7calcium44 49 11 2412.9GALNT3, SYP, POSTN, MUC2, MUC6, CDX2
8cholesterol44 28 11 2412.8SYP, MUC2, MUC6, CDKN1C, SLPI

GO Terms for genes affiliated with Bile Duct Carcinoma

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16Gene Ontology
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Cellular components related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.3SDC1, MUC6, MUC2

Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1detection of chemical stimulus involved in sensory perception of sweet tasteGO:00158210.4TAS1R2, TAS1R3
2sensory perception of umami tasteGO:05091710.4TAS1R1, TAS1R3
3post-translational protein modificationGO:04368710.2MUC6, MUC2, MGAT3, GALNT3
4O-glycan processingGO:01626610.2GALNT3, MUC2, MUC6
5sensory perception of sweet tasteGO:05091610.1TAS1R2, TAS1R3

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.2CEBPB, TAS1R1, TAS1R2, TAS1R3
2taste receptor activityGO:00852710.2TAS1R1, TAS1R2, TAS1R3
3sweet taste receptor activityGO:03304110.1TAS1R2, TAS1R3

Products for genes affiliated with Bile Duct Carcinoma

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  • Antibodies
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Sources for Bile Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet