MCID: BLD034
MIFTS: 48

Bile Duct Carcinoma malady

Rare diseases, Cancer diseases, Liver diseases categories
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Summaries for Bile Duct Carcinoma

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MedlinePlus:33 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards based summary: Bile Duct Carcinoma, also known as bile duct cancer, is related to gallbladder cancer and cholangiocarcinoma. An important gene associated with Bile Duct Carcinoma is TAS1R3 (taste receptor, type 1, member 3), and among its related pathways are Carbohydrate digestion and absorption and Taste transduction. The compounds aspartame and deoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and skin, and related mouse phenotypes are taste/olfaction and limbs/digits/tail.

Disease Ontology:8 A bile duct cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

Wikipedia:65 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

Aliases & Classifications for Bile Duct Carcinoma

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Bile Duct Carcinoma, Aliases & Descriptions:

Name: Bile Duct Carcinoma 8 62
Bile Duct Cancer 42 44 33
Carcinoma of Extrahepatic Bile Duct 62
 
Extrahepatic Bile Duct Carcinoma 10
Bile Duct Extrahepatic Carcinoma 44
Extrahepatic Bile Duct Cancer 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology8 DOID:4897
MeSH34 D001650
SNOMED-CT57 70179006
NCIt39 C27814
ICD1025 C24.0

Related Diseases for Bile Duct Carcinoma

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Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.7MUC2, CDX2
2cholangiocarcinoma30.2EBAG9, CDX2, MUC2
3adenocarcinoma29.9EBAG9, MUC2, CDKN1C, CDX2
4hepatitis10.7
5ulcerative colitis10.6
6colitis10.6
7cholangitis10.6
8sclerosing cholangitis10.5
9adenosquamous bile duct carcinoma10.5
10squamous cell bile duct carcinoma10.4
11bile duct carcinoma in situ10.4
12obstructive jaundice10.3
13extrahepatic bile duct small cell adenocarcinoma10.3
14klatskin's tumor10.3
15intrahepatic cholangiocarcinoma10.3
16pancreatitis10.3
17primary sclerosing cholangitis10.3
18alpha 1-antitrypsin deficiency10.2
19hepatitis b10.2
20liver disease10.2
21situs inversus10.2
22choledochal cyst10.2
23inflammatory myofibroblastic tumor10.2
24portal vein thrombosis10.2
25choledocholithiasis10.2
26liver carcinoma in situ10.2
27cholecystolithiasis10.2
28bile duct adenocarcinoma10.2
29extrahepatic bile duct adenocarcinoma10.2
30in situ carcinoma10.2
31neuroma10.2
32peritonitis10.2
33retinoblastoma10.2
34sarcoidosis10.2
35congenital hepatic fibrosis10.2
36ileus10.2
37mucinous adenocarcinoma10.2
38lynch syndrome10.2
39autoimmune pancreatitis10.2
40microinvasive gastric cancer10.0MUC2, CDX2
41pseudomyxoma peritonei10.0CDX2, MUC2
42bronchiolo-alveolar adenocarcinoma10.0MUC2, CDX2
43cervical adenocarcinoma10.0CDX2, EBAG9
44tubular adenocarcinoma10.0CDX2, MUC2
45barrett's esophagus10.0MUC2, CDX2
46pancreatic cancer9.9CDX2, MUC2
47familial adenomatous polyposis9.8MUC2, CDX2
48gastric adenocarcinoma9.8MUC2, CDX2
49stomach cancer9.7EBAG9, CDX2, MUC2
50ovarian cancer9.7MUC2, EBAG9, CDX2

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Symptoms for Bile Duct Carcinoma

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Drugs & Therapeutics for Bile Duct Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

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Anatomical Context for Bile Duct Carcinoma

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MalaCards organs/tissues related to Bile Duct Carcinoma:

32
Liver, Small intestine, Skin, Lymph node, Pancreas, Brain, Colon, Lung

Animal Models for Bile Duct Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Bile Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3TAS1R1, TAS1R3, TAS1R2
2MP:00053718.7CDKN1C, CDX2, KRT9
3MP:00053797.8CDKN1C, CDX2, TAS1R1, MUC2
4MP:00053847.6MUC2, KRT9, TAS1R1, CDX2, CDKN1C

Publications for Bile Duct Carcinoma

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Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
A novel technique for endoscopic transpapillary "mapping biopsy specimens" of superficial intraductal spread of bile duct carcinoma (with videos). (24674353)
2014
2
Pancreaticobiliary maljunction is associated with common bile duct carcinoma: a meta-analysis. (24489507)
2013
3
Characterization of two novel cell lines with distinct heterogeneity derived from a single human bile duct carcinoma. (23382894)
2013
4
Adenocarcinoma with pyloric gland phenotype of the extrahepatic bile ducts: a previously unrecognized and distinctive morphologic variant of extrahepatic bile duct carcinoma. (22795356)
2012
5
Photodynamic therapy using talaporfin sodium (LaserphyrinAr) for bile duct carcinoma: a preliminary clinical trial. (23155262)
2012
6
Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma. (21360081)
2011
7
Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas. (20459570)
2010
8
The ratio between metastatic and examined lymph nodes is an independent prognostic factor for patients with resectable middle and distal bile duct carcinoma. (19596119)
2010
9
A novel approach for treatment of unresectable extrahepatic bile duct carcinoma: design of radioactive stents and an experimental trial in healthy pigs. (19231492)
2009
10
Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma. (19054142)
2009
11
67-kDa laminin receptor in human bile duct carcinoma. (19182490)
2009
12
An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma. (18473424)
2008
13
p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance. (17385050)
2007
14
Numerical Calculations of Heating Patterns around a Coaxial-Slot Antenna for Microwave Hyperthermia - Aiming at Treatment of Brain Tumor and Bile Duct Carcinoma-. (17282220)
2005
15
Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics. (15138129)
2004
16
Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma. (15138553)
2004
17
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma. (15238704)
2004
18
The expression and significance of human telomerase reverse transcriptase protein and gene in bile duct carcinomas and their adjacent tissues]. (15059327)
2004
19
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response. (14756433)
2003
20
Intraluminal low-dose-rate 192Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable extrahepatic bile duct carcinoma. (14630274)
2003
21
Surgical treatment of hilar bile duct carcinoma: experience with 25 consecutive hepatectomies. (12127130)
2002
22
Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma. (11815973)
2002
23
Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis. (12685548)
2002
24
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
25
Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma. (10707878)
2000
26
Establishment and characterization of human hilar bile duct carcinoma cell line and cell strain. (11180864)
2000
27
Surgical treatment and postoperative outcomes for middle and lower bile duct carcinoma in Japan--experience of a single institute. (10919005)
2000
28
ets-1 expression in extrahepatic bile duct carcinoma and cholangiocellular carcinoma. (10765128)
2000
29
Extrahepatic bile duct carcinoma: a western experience with 118 consecutive patients. (10791187)
2000
30
Limitation of cholangiography in assessing longitudinal spread of extrahepatic bile duct carcinoma to the hepatic side. (10440214)
1999
31
Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma. (9701213)
1998
32
Extended right trisegmentectomy for hilar bile duct carcinoma. (9261589)
1997
33
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma. (9369143)
1997
34
Bile duct carcinoma without jaundice: clues to early diagnosis. (9356876)
1997
35
The role of urokinase type plasminogen activator in invasion of bile duct carcinoma]. (9275473)
1996
36
Combined liver transplantation and pancreatoduodenectomy for irresectable hilar bile duct carcinoma. (8665214)
1996
37
Bile duct carcinoma arising from the anastomotic site of hepaticojejunostomy after the excision of congenital biliary dilatation: a case report. (8644016)
1996
38
Intraluminal brachytherapy in the treatment of pancreas and bile duct carcinoma. (7538501)
1995
39
Case of bile duct carcinoma of the hepatic hilus with segmental obstructive cholangitis. (8751205)
1995
40
Synchronous carcinoma of the gall-bladder in patients with bile duct carcinoma. (8031336)
1993
41
Clinicopathologic studies on perineural invasion of bile duct carcinoma. (1558415)
1992
42
Radiation therapy in extrahepatic bile duct carcinoma. (1866463)
1991
43
Preoperative TNM classification of proximal extrahepatic bile duct carcinoma by endosonography. (2162563)
1990
44
The infiltration of bile duct carcinoma along the bile duct wall. (2840410)
1988
45
Bile duct carcinoma in an adolescent. (4003379)
1985
46
Surgical management of primary bile-duct carcinoma. (6205739)
1984
47
Management of high bile duct carcinoma. (6203447)
1984
48
The diagnosis of primary bile duct carcinoma (cholangiocarcinoma) in the jaundiced patient. (6263536)
1981
49
Prognostic factors in bile duct carcinoma: analysis of 96 cases. (7283506)
1981
50
Bile duct carcinoma mimicking chronic liver disease. (183615)
1976

Variations for Bile Duct Carcinoma

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Expression for genes affiliated with Bile Duct Carcinoma

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Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

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Compounds for genes affiliated with Bile Duct Carcinoma

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame44 24 1111.6TAS1R3, TAS1R2
2deoxycholic acid44 28 24 1112.1CDX2, MUC2
35-aza-2deoxycytidine448.2CDKN1C, CDX2, MUC2

GO Terms for genes affiliated with Bile Duct Carcinoma

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Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of umami tasteGO:0509179.7TAS1R1, TAS1R3
2detection of chemical stimulus involved in sensory perception of sweet tasteGO:0015829.6TAS1R3, TAS1R2
3sensory perception of sweet tasteGO:0509169.4TAS1R3, TAS1R2

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sweet taste receptor activityGO:0330419.4TAS1R3, TAS1R2
2protein heterodimerization activityGO:0469829.3TAS1R1, TAS1R3, TAS1R2
3taste receptor activityGO:0085279.2TAS1R1, TAS1R3, TAS1R2

Products for genes affiliated with Bile Duct Carcinoma

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Sources for Bile Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet