MCID: BLD034
MIFTS: 49

Bile Duct Carcinoma malady

Cancer, Liver categories

Summaries for Bile Duct Carcinoma

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards: Bile Duct Carcinoma, also known as bile duct cancer, is related to adenocarcinoma and neuroendocrine carcinoma. An important gene associated with Bile Duct Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Class C/3 (Metabotropic glutamate/pheromone receptors) and O-linked glycosylation of mucins. The compounds aspartame and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and small intestine, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that starts in the bile duct.

Wikipedia:64 Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial... more...

Aliases & Classifications for Bile Duct Carcinoma

Sources:
8Disease Ontology, 61UMLS, 43NIH Rare Diseases, 45Novoseek, 34MedlinePlus, 10DISEASES, 35MeSH, 40NCIt, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Aliases & Descriptions:

bile duct carcinoma 8 61
bile duct cancer 43 45 34
carcinoma of extrahepatic bile duct 61
extrahepatic bile duct carcinoma 10
bile duct extrahepatic carcinoma 45
extrahepatic bile duct cancer 43


External Ids:

Disease Ontology8 DOID:4897
MeSH35 D001650
SNOMED-CT57 70179006
NCIt40 C27814
ICD1025 C24.0

Related Diseases for Bile Duct Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6SYP, EBAG9, MUC2, MUC6, CDX2, CDKN1C
2neuroendocrine carcinoma30.2SYP, CDX2, FSCN1
3pancreatic ductal carcinoma30.2MUC6, MUC2
4pancreatitis, chronic30.2FSCN1, MUC6, MUC2
5ulcerative colitis10.6
6adenosquamous carcinoma10.5
7bile duct carcinoma in situ10.5
8sclerosing cholangitis10.5
9adenosquamous bile duct carcinoma10.4
10squamous cell bile duct carcinoma10.4
11klatskin's tumor10.4
12bile duct adenocarcinoma10.4
13bile duct disease10.4
14small cell carcinoma10.4
15hepatitis c10.3
16obstructive jaundice10.3
17extrahepatic bile duct small cell adenocarcinoma10.3
18hepatitis b10.3
19hepatitis d10.3
20bladder carcinoma10.3
21primary sclerosing cholangitis10.3
22common bile duct neoplasm10.2
23mucinous adenocarcinoma10.2
24bile duct mucinous adenocarcinoma10.2
25autoimmune pancreatitis10.2
26bone carcinoma10.2
27hepatitis e10.2
28cholecystolithiasis10.2
29liver carcinoma in situ10.2
30portal vein thrombosis10.2
31choledocholithiasis10.2
32situs inversus10.2
33choledochal cyst10.2
34viral hepatitis10.2
35congenital hepatic fibrosis10.2
36bile duct cysts10.2
37inflammatory myofibroblastic tumor10.2
38hepatitis c virus10.2
39ileus10.2
40peritoneal carcinoma10.2
41congenital pancreatic cyst10.2
42esophagitis10.0CDX2
43lung cancer10.0SYP
44gallbladder cancer10.0CDX2, MUC2
45colon adenocarcinoma10.0MUC2
46gastritis10.0CDX2, MUC6
47pseudomyxoma peritonei10.0MUC2, MUC6, CDX2
48bronchiolo-alveolar adenocarcinoma10.0MUC2, MUC6, CDX2
49colon cancer10.0FSCN1, CDX2, MUC2
50tubular adenocarcinoma10.0SYP, MUC2, CDX2

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Clinical Features for Bile Duct Carcinoma

Drugs & Therapeutics for Bile Duct Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bile Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Search CenterWatch for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

Anatomical Context for Bile Duct Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bile Duct Carcinoma:

33
Lymph node, Brain, Small intestine, Colon, Liver, Lung, Pancreas, Adrenal gland, Skin, T cells, B cells

Animal Models for Bile Duct Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bile Duct Carcinoma

Sources:
51PubMed
See all sources

Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 353)
idTitleAuthorsYear
1
Biliary tumor fragment of hepatocellular carcinoma containing lipiodol mimicking a bile duct stone. (24405219)
2014
2
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case. (22623519)
2013
3
Photodynamic therapy using talaporfin sodium (LaserphyrinAr) for bile duct carcinoma: a preliminary clinical trial. (23155262)
2012
4
Well-differentiated endocrine carcinoma originating from the bile duct in association with a congenital choledochal cyst. (23294072)
2012
5
Bile aspiration cytology in diagnosis of bile duct carcinoma: factors associated with positive yields. (21785970)
2012
6
Extensively spreading intraepithelial bile duct carcinoma causing multiple bile duct strictures: report of three cases. (21969205)
2011
7
Efficacy and safety of capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated pancreatic, gallbladder, and bile duct carcinoma. (20224968)
2010
8
Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature. (19669289)
2008
9
Bile duct carcinoma in a gelding. (18310563)
2008
10
Bile-reflux into the pancreatic ducts is associated with the development of intraductal papillary carcinoma in hamsters. (16863651)
2006
11
Composite large cell neuroendocrine carcinoma and adenocarcinoma of the common bile duct. (16394290)
2006
12
Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma. (16723853)
2006
13
A case of small cell carcinoma of the common bile duct. (15816436)
2005
14
Bile duct carcinoma and nasal adenocarcinoma in a guinea pig. (15759833)
2005
15
Histological characteristics of tumor cells and stromal cells in vessels and lymph nodes are important prognostic parameters of extrahepatic bile duct carcinoma: a prospective study. (16021572)
2005
16
Role of hepatectomy in the treatment of hilar bile duct carcinoma. (15108077)
2004
17
Tumor-associated focal chronic pancreatitis from invasion of the pancreatic duct by common bile duct carcinoma: radiologic-pathologic correlation. (12719908)
2003
18
Hepatectomy for proximal bile duct carcinoma in a patient with situs inversus; a case report. (14571715)
2003
19
Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma. (12737162)
2003
20
Surgical treatment of hilar bile duct carcinoma: experience with 25 consecutive hepatectomies. (12127130)
2002
21
Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma. (11815973)
2002
22
Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis. (12685548)
2002
23
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
24
Transpapillary intraductal US prior to biliary drainage in the assessment of longitudinal spread of extrahepatic bile duct carcinoma. (11231387)
2001
25
A case of clear cell carcinoma of the hepatic bile duct with production of alpha-fetoprotein (AFP)]. (10934880)
2000
26
Chemotherapy for bile duct carcinoma in the light of adjuvant chemotherapy to surgery. (10919004)
2000
27
Alterations of retinoblastoma protein and p16INK4 protein expression in extrahepatic bile duct carcinomas. (11100316)
2000
28
Metastatic seeding of bile duct carcinoma in the transhepatic catheter tract: report of a case. (10639708)
1999
29
Preoperative assessment of extrahepatic bile duct carcinoma using three-dimensional intraductal US. (10502180)
1999
30
Limitations of percutaneous transhepatic cholangioscopy for the diagnosis of the intramural extension of bile duct carcinoma. (9615877)
1998
31
Extended right trisegmentectomy for hilar bile duct carcinoma. (9261589)
1997
32
Regression of a distal bile duct carcinoma after treatment with octreotide for 6 months. (9324171)
1997
33
Does bile spillage during an operation present a risk for peritoneal metastasis in bile duct carcinoma? (9413052)
1997
34
Combined liver transplantation and pancreatoduodenectomy for irresectable hilar bile duct carcinoma. (8665214)
1996
35
Bacteriological studies of bile from the gallbladder in patients with carcinoma of the gallbladder, cholelithiasis, common bile duct stones and no gallstones disease. (7948355)
1994
36
Composite glandular-endocrine cell carcinoma of the extrahepatic bile duct: immunohistochemical study. (8316508)
1993
37
Long-term survival of a patient with bile duct carcinoma by endoscopic biliary drainage. (8420257)
1993
38
Lack of increase in heterozygous alpha 1-antitrypsin deficiency phenotypes among patients with hepatocellular and bile duct carcinoma. (1312055)
1992
39
A case of cutaneous metastasis of bile duct carcinoma. (1666397)
1991
40
Bile duct carcinoma and biliary tract dysplasia in chronic ulcerative colitis. (2705876)
1989
41
Treatment of inoperable bile duct carcinoma. (2482991)
1989
42
The development and extension of hepatohilar bile duct carcinoma. A three-dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system. (2545324)
1989
43
Surgical management of primary bile-duct carcinoma. (6205739)
1984
44
Endocrine cells in extrahepatic bile duct carcinoma. (6150939)
1984
45
Newer techniques in the diagnosis and treatment of proximal bile duct carcinoma--an analysis of 41 consecutive patients. (7330164)
1981
46
Percutaneous transhepatic portography in bile duct carcinoma. Correlation with percutaneous transhepatic cholangiography and angiography. (225246)
1979
47
Bile duct carcinoma associated with an anomaly in the bile duct. (429187)
1979
48
Metastatic colon carcinoma simulating primary bile duct carcinoma via endoscopic cholangiography. (615806)
1977
49
Small-bowel metastasis from bile duct carcinoma with coincidental congenital absence of gallbladder. (1264889)
1976
50
Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma. (5929253)
1966

Genetic Variations for Bile Duct Carcinoma

Expression for genes affiliated with Bile Duct Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

Sources:
54Reactome, 30KEGG
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Pathways related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3TAS1R1, TAS1R2, TAS1R3
2
Hide members
10.3MUC6, MUC2, GALNT3

Compounds for genes affiliated with Bile Duct Carcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
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Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame45 11 2412.5TAS1R3, TAS1R2
2hematoxylin4510.3SYP, MUC2, SLPI
3paraffin4510.3CDX2, SYP, MUC2, MUC6, FSCN1
4oligonucleotide4510.1MUC2, MUC6, CDX2, SLPI, CEBPB
5progesterone45 60 29 11 2414.0SYP, MUC2, MUC6, CDX2, CEBPB
6retinoic acid45 2411.0CEBPB, SLPI, FSCN1, MUC2, SYP, MGAT3
7calcium45 50 11 2412.9CDX2, FSCN1, MUC6, SLPI, MUC2, POSTN
8cholesterol45 29 11 2412.8SYP, MUC2, MUC6, CDKN1C, SLPI

GO Terms for genes affiliated with Bile Duct Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.3SDC1, MUC6, MUC2

Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1detection of chemical stimulus involved in sensory perception of sweet tasteGO:00158210.4TAS1R2, TAS1R3
2sensory perception of umami tasteGO:05091710.4TAS1R1, TAS1R3
3post-translational protein modificationGO:04368710.2GALNT3, MGAT3, MUC2, MUC6
4O-glycan processingGO:01626610.2GALNT3, MUC2, MUC6
5sensory perception of sweet tasteGO:05091610.1TAS1R2, TAS1R3

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.2CEBPB, TAS1R1, TAS1R2, TAS1R3
2taste receptor activityGO:00852710.2TAS1R1, TAS1R2, TAS1R3
3sweet taste receptor activityGO:03304110.1TAS1R2, TAS1R3

Products for genes affiliated with Bile Duct Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bile Duct Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet