MCID: BLD034
MIFTS: 52

Bile Duct Carcinoma malady

Cancer diseases, Liver diseases categories

Summaries for Bile Duct Carcinoma

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards: Bile Duct Carcinoma, also known as bile duct cancer, is related to gallbladder cancer and cholangiocarcinoma. An important gene associated with Bile Duct Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Class C/3 (Metabotropic glutamate/pheromone receptors) and O-linked glycosylation of mucins. The compounds aspartame and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and skin, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that starts in the bile duct.

Wikipedia:63 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

Aliases & Classifications for Bile Duct Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct carcinoma 8 60
bile duct cancer 42 44 33
carcinoma of extrahepatic bile duct 60
extrahepatic bile duct carcinoma 10
bile duct extrahepatic carcinoma 44
extrahepatic bile duct cancer 42


External Ids:

Disease Ontology8 DOID:4897
MeSH34 D001650
SNOMED-CT56 70179006
NCIt39 C27814
ICD1025 C24.0

Related Diseases for Bile Duct Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Bile Duct Carcinoma family:

Common Bile Duct Neoplasm Bile Duct Carcinoma in Situ

Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.8MUC2, CDX2
2cholangiocarcinoma30.5EBAG9, MUC2, CDX2, SLPI
3adenocarcinoma30.5FSCN1, SYP, EBAG9, MUC2, CDKN1C, MUC6
4neuroendocrine carcinoma30.2FSCN1, SYP, CDX2
5hepatocellular carcinoma30.2MGAT3, EBAG9, MUC2, CDX2, CDKN1C
6pancreatic cancer30.2MUC2, MUC6, CDX2, SYP
7hepatitis10.7
8ulcerative colitis10.6
9cholangitis10.6
10bile duct carcinoma in situ10.5
11adenosquamous carcinoma10.5
12sclerosing cholangitis10.4
13adenosquamous bile duct carcinoma10.4
14squamous cell bile duct carcinoma10.4
15bile duct adenocarcinoma10.4
16bile duct disease10.4
17in situ carcinoma10.4
18small cell carcinoma10.3
19obstructive jaundice10.3
20extrahepatic bile duct small cell adenocarcinoma10.3
21klatskin's tumor10.3
22bladder carcinoma10.3
23extrahepatic bile duct adenocarcinoma10.3
24pancreatitis10.3
25bone carcinoma10.1
26cholecystolithiasis10.1
27liver carcinoma in situ10.1
28portal vein thrombosis10.1
29choledocholithiasis10.1
30situs inversus10.1
31hepatitis b10.1
32choledochal cyst10.1
33alpha 1-antitrypsin deficiency10.1
34hepatitis a10.1
35gastric adenocarcinoma10.1
36intrahepatic cholangiocarcinoma10.1
37liver disease10.1
38neuroma10.1
39peritonitis10.1
40retinoblastoma10.1
41sarcoidosis10.1
42viral hepatitis10.1
43congenital hepatic fibrosis10.1
44common bile duct neoplasm10.1
45mucinous adenocarcinoma10.1
46bile duct mucinous adenocarcinoma10.1
47gallbladder adenocarcinoma10.1
48lymph node cancer10.1
49lynch syndrome10.1
50esophagitis10.0CDX2

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Clinical Features for Bile Duct Carcinoma

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Drugs & Therapeutics for Bile Duct Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Search CenterWatch for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

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Anatomical Context for Bile Duct Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Bile Duct Carcinoma:

32
Liver, Small intestine, Skin, Pancreas, Lymph node, Bone, Brain, Lung, Colon

Animal Models for Bile Duct Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bile Duct Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.3TAS1R1, TAS1R2, TAS1R3
2MP:000537910.0SDC1, GALNT3, POSTN, MUC2, CDX2, CDKN1C
3MP:00020069.9MGAT3, POSTN, MUC2, CDX2, CEBPB, SDC1
4MP:00053899.8GALNT3, CDX2, CDKN1C, TAS1R1, CEBPB
5MP:00053849.7MGAT3, POSTN, MUC2, CDX2, CDKN1C, TAS1R1

Publications for Bile Duct Carcinoma

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50PubMed
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Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 351)
idTitleAuthorsYear
1
Hepatocellular Carcinoma Presenting As Bile Duct Tumor: A Case Report. (24408273)
2014
2
Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma. (23269460)
2013
3
Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma. (22835954)
2013
4
Extended right hepatectomy for hilar bile duct carcinoma using the modified liver hanging maneuver. (22683977)
2012
5
Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma. (21360081)
2011
6
Post-cholecystectomy amputation neuroma mimicking common bile duct carcinoma. (21861328)
2011
7
Pancreatoduodenectomy for local intrapancreatic recurrence after bile duct resection of mid bile duct carcinoma. (21410028)
2010
8
A novel approach for treatment of unresectable extrahepatic bile duct carcinoma: design of radioactive stents and an experimental trial in healthy pigs. (19231492)
2009
9
Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma. (19054142)
2009
10
Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma. (19420730)
2009
11
Main bile duct carcinoma management. Our experience on 38 cases. (19681291)
2009
12
Small cell carcinoma of extrahepatic bile duct presenting with hemobilia]. (19844156)
2009
13
An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma. (18473424)
2008
14
Minimally invasive papillary carcinoma of the extrahepatic bile ducts. (18940127)
2008
15
Distal bile duct carcinoma: prognostic factors after curative surgery. A series of 112 cases. (17176983)
2007
16
Promoter hypermethylation of the p16 gene and loss of its protein expression is correlated with tumor progression in extrahepatic bile duct carcinomas. (16390235)
2006
17
Preoperative staging accuracy of multidetector row computed tomography for extrahepatic bile duct carcinoma. (16778607)
2006
18
MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. (16857800)
2006
19
Thermo-chemo-radiotherapy for advanced bile duct carcinoma. (16015690)
2005
20
Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma. (15138553)
2004
21
The expression and significance of human telomerase reverse transcriptase protein and gene in bile duct carcinomas and their adjacent tissues]. (15059327)
2004
22
Severe high-grade dysplasia and in-situ carcinoma of the common bile duct and pancreatic duct. (12788411)
2003
23
RCAS1 expression as a prognostic factor after curative surgery for extrahepatic bile duct carcinoma. (11986191)
2002
24
Destruction of a bile duct carcinoma by intraductal high intensity ultrasound during ERCP. (11375595)
2001
25
A rare case of primary adenoendocrine cell carcinoma of lower bile duct with anomalous creatine kinase isoenzyme and extremely high serum level of neuron specific enolase]. (11573275)
2001
26
Establishment and characterization of human hilar bile duct carcinoma cell line and cell strain. (11180864)
2000
27
ets-1 expression in extrahepatic bile duct carcinoma and cholangiocellular carcinoma. (10765128)
2000
28
Intraductal US in assessing the effects of radiation therapy and prediction of patency of metallic stents in extrahepatic bile duct carcinoma. (10744810)
2000
29
Fas-Fas ligand pathway does not actively work in extrahepatic bile duct carcinoma. (10928141)
2000
30
Limitations of three-dimensional intraductal ultrasonography in the assessment of longitudinal spread of extrahepatic bile duct carcinoma. (11573728)
2000
31
Arterial dynamic appearance of common bile duct carcinoma by helical CT on angiography (angio-HCT): four operated cases. (10050811)
1999
32
DNA quantitation of distal bile duct carcinoma measured by image and flow cytometry. (10560507)
1999
33
Staging of bile duct carcinoma by EUS and IDUS. (9765105)
1998
34
The role of urokinase type plasminogen activator in invasion of bile duct carcinoma]. (9275473)
1996
35
Definitive radiation therapy for extrahepatic bile duct carcinoma. (7784581)
1995
36
Right or left trisegment portal vein embolization before hepatic trisegmentectomy for hilar bile duct carcinoma. (7778031)
1995
37
Concomitant adenosquamous carcinoma of the common bile duct and early adenocarcinoma of the gall-bladder. (8280849)
1993
38
Insemination of bile duct carcinoma to the liver after insertion of percutaneous biliary endoprosthesis. (1752399)
1991
39
High-dose-rate intraluminal brachytherapy for bile duct carcinoma after surgery. (1712977)
1991
40
Assessment of serum and bile levels of CA19-9 and CA125 in cholangitis and bile duct carcinoma. (1657243)
1991
41
Preoperative TNM classification of proximal extrahepatic bile duct carcinoma by endosonography. (2162563)
1990
42
Bile duct carcinoma simulating choledocholithiasis. (2304664)
1990
43
The role of radiotherapy in the treatment of bile duct carcinoma. (2153649)
1990
44
Definitive radiation therapy in bile duct carcinoma. (2843489)
1988
45
Bile duct carcinoma in an adolescent. (4003379)
1985
46
Analysis of failure following curative irradiation of gallbladder and extrahepatic bile duct carcinoma. (6436203)
1984
47
Radiotherapy of high bile duct carcinoma using intra-catheter iridium 192 wire. (6207904)
1984
48
A study on multiple bile duct carcinoma. (6267146)
1981
49
Bile duct carcinoma associated with chronic ulcerative colitis. (7472101)
1981
50
Bile duct carcinoma in a goat. (919247)
1977

Genetic Variations for Bile Duct Carcinoma

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Expression for genes affiliated with Bile Duct Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

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53Reactome, 29KEGG
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Pathways related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3TAS1R1, TAS1R2, TAS1R3
2
Hide members
10.3MUC6, MUC2, GALNT3

Compounds for genes affiliated with Bile Duct Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame44 11 2412.5TAS1R3, TAS1R2
2hematoxylin4410.3SYP, MUC2, SLPI
3paraffin4410.3CDX2, SYP, MUC2, MUC6, FSCN1
4oligonucleotide4410.1MUC2, MUC6, CDX2, SLPI, CEBPB
5progesterone44 59 28 11 2414.0SYP, MUC2, MUC6, CDX2, CEBPB
6retinoic acid44 2411.0CEBPB, SLPI, FSCN1, MUC2, SYP, MGAT3
7calcium44 49 11 2412.9CDX2, FSCN1, MUC6, SLPI, MUC2, POSTN
8cholesterol44 28 11 2412.8SYP, MUC2, MUC6, CDKN1C, SLPI

GO Terms for genes affiliated with Bile Duct Carcinoma

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16Gene Ontology
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Cellular components related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.3SDC1, MUC6, MUC2

Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1detection of chemical stimulus involved in sensory perception of sweet tasteGO:00158210.4TAS1R2, TAS1R3
2sensory perception of umami tasteGO:05091710.4TAS1R1, TAS1R3
3post-translational protein modificationGO:04368710.2GALNT3, MGAT3, MUC2, MUC6
4O-glycan processingGO:01626610.2GALNT3, MUC2, MUC6
5sensory perception of sweet tasteGO:05091610.1TAS1R2, TAS1R3

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.2CEBPB, TAS1R1, TAS1R2, TAS1R3
2taste receptor activityGO:00852710.2TAS1R1, TAS1R2, TAS1R3
3sweet taste receptor activityGO:03304110.1TAS1R2, TAS1R3

Products for genes affiliated with Bile Duct Carcinoma

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  • Antibodies
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Sources for Bile Duct Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet