MCID: BLD034
MIFTS: 48

Bile Duct Carcinoma malady

Rare diseases, Cancer diseases, Liver diseases categories

Summaries for Bile Duct Carcinoma

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your liver makes a substance called bile that helps with digestion. your gallbladder stores it until you need it to digest fat. then your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. bile duct cancer is rare. it can happen in the part of the bile duct that is outside or inside the liver. cancer of the bile duct outside of the liver is much more common. risk factors include inflammation of the bile duct, older age, some liver diseases, and exposure to certain chemicals. symptoms can include jaundice itchy skin fever abdominal pain weight loss treatments include surgery, radiation therapy, and chemotherapy.

MalaCards: Bile Duct Carcinoma, also known as bile duct cancer, is related to gallbladder cancer and cholangiocarcinoma. An important gene associated with Bile Duct Carcinoma is TAS1R3 (taste receptor, type 1, member 3), and among its related pathways are Carbohydrate digestion and absorption and Taste transduction. The compounds aspartame and deoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and skin, and related mouse phenotypes are taste/olfaction and limbs/digits/tail.

Disease Ontology:9 A carcinoma that starts in the bile duct.

Wikipedia:66 Cholangiocarcinoma is a form of cancer that is composed of mutated epithelial cells (or cells showing... more...

Aliases & Classifications for Bile Duct Carcinoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

bile duct carcinoma 9 63
bile duct cancer 44 46 35
carcinoma of extrahepatic bile duct 63
extrahepatic bile duct carcinoma 11
bile duct extrahepatic carcinoma 46
extrahepatic bile duct cancer 44


External Ids:

Disease Ontology9 DOID:4897
NCIt41 C27814
SNOMED-CT59 70179006
MeSH36 D001650
ICD1026 C24.0

Related Diseases for Bile Duct Carcinoma

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18GeneCards, 19GeneDecks
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Diseases in the Bile Duct Carcinoma family:

Common Bile Duct Neoplasm Bile Duct Carcinoma in Situ

Diseases related to Bile Duct Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1gallbladder cancer30.7CDX2, MUC2
2cholangiocarcinoma30.6EBAG9, MUC2, CDX2
3adenocarcinoma30.4CDKN1C, CDX2, MUC2, EBAG9
4hepatitis10.7
5ulcerative colitis10.6
6cholangitis10.6
7sclerosing cholangitis10.5
8squamous cell bile duct carcinoma10.4
9bile duct carcinoma in situ10.4
10adenosquamous bile duct carcinoma10.4
11obstructive jaundice10.3
12extrahepatic bile duct small cell adenocarcinoma10.3
13klatskin's tumor10.3
14pancreatitis10.3
15primary sclerosing cholangitis10.3
16portal vein thrombosis10.2
17choledocholithiasis10.2
18situs inversus10.2
19hepatitis b10.2
20choledochal cyst10.2
21cholecystolithiasis10.2
22liver carcinoma in situ10.2
23alpha 1-antitrypsin deficiency10.2
24in situ carcinoma10.2
25intrahepatic cholangiocarcinoma10.2
26liver disease10.2
27neuroma10.2
28peritonitis10.2
29retinoblastoma10.2
30sarcoidosis10.2
31congenital hepatic fibrosis10.2
32inflammatory myofibroblastic tumor10.2
33ileus10.2
34mucinous adenocarcinoma10.2
35lynch syndrome10.2
36autoimmune pancreatitis10.2
37microinvasive gastric cancer10.0CDX2, MUC2
38pseudomyxoma peritonei10.0CDX2, MUC2
39bronchiolo-alveolar adenocarcinoma10.0CDX2, MUC2
40cervical adenocarcinoma10.0EBAG9, CDX2
41tubular adenocarcinoma10.0CDX2, MUC2
42barrett's esophagus10.0CDX2, MUC2
43pancreatic cancer10.0CDX2, MUC2
44familial adenomatous polyposis10.0MUC2, CDX2
45gastric adenocarcinoma9.9MUC2, CDX2
46stomach cancer9.9EBAG9, MUC2, CDX2
47ovarian cancer9.9CDX2, MUC2, EBAG9
48non-small cell lung carcinoma9.9EBAG9, MUC2, CDX2
49adenoma9.9CDKN1C, CDX2, MUC2, EBAG9
50hepatocellular carcinoma9.9EBAG9, MUC2, CDX2, CDKN1C

Graphical network of the top 20 diseases related to Bile Duct Carcinoma:



Diseases related to bile duct carcinoma

Symptoms for Bile Duct Carcinoma

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Drugs & Therapeutics for Bile Duct Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bile Duct Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bile Duct Carcinoma

Search NIH Clinical Center for Bile Duct Carcinoma

Search CenterWatch for Bile Duct Carcinoma

Genetic Tests for Bile Duct Carcinoma

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Anatomical Context for Bile Duct Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Bile Duct Carcinoma:

34
Liver, Small intestine, Skin, Lymph node, Pancreas, Bone, Brain, Colon, Lung

Animal Models for Bile Duct Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bile Duct Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3TAS1R1, TAS1R3, TAS1R2
2MP:00053718.7CDKN1C, CDX2, KRT9
3MP:00053797.8CDKN1C, CDX2, TAS1R1, MUC2
4MP:00053847.6MUC2, KRT9, TAS1R1, CDX2, CDKN1C

Publications for Bile Duct Carcinoma

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53PubMed
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Articles related to Bile Duct Carcinoma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Characterization of two novel cell lines with distinct heterogeneity derived from a single human bile duct carcinoma. (23382894)
2013
2
Adenocarcinoma with pyloric gland phenotype of the extrahepatic bile ducts: a previously unrecognized and distinctive morphologic variant of extrahepatic bile duct carcinoma. (22795356)
2012
3
Photodynamic therapy using talaporfin sodium (LaserphyrinAr) for bile duct carcinoma: a preliminary clinical trial. (23155262)
2012
4
Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma. (21360081)
2011
5
Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas. (20459570)
2010
6
The ratio between metastatic and examined lymph nodes is an independent prognostic factor for patients with resectable middle and distal bile duct carcinoma. (19596119)
2010
7
A novel approach for treatment of unresectable extrahepatic bile duct carcinoma: design of radioactive stents and an experimental trial in healthy pigs. (19231492)
2009
8
Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma. (19054142)
2009
9
67-kDa laminin receptor in human bile duct carcinoma. (19182490)
2009
10
Three-dimensional cholangiography applying C-arm computed tomography in bile duct carcinoma: a new radiological technique. (19621666)
2009
11
An autopsy case of granulocyte-colony-stimulating-factor-producing extrahepatic bile duct carcinoma. (18473424)
2008
12
p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance. (17385050)
2007
13
Numerical Calculations of Heating Patterns around a Coaxial-Slot Antenna for Microwave Hyperthermia - Aiming at Treatment of Brain Tumor and Bile Duct Carcinoma-. (17282220)
2005
14
Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics. (15138129)
2004
15
Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma. (15138553)
2004
16
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma. (15238704)
2004
17
The expression and significance of human telomerase reverse transcriptase protein and gene in bile duct carcinomas and their adjacent tissues]. (15059327)
2004
18
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response. (14756433)
2003
19
Intraluminal low-dose-rate 192Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable extrahepatic bile duct carcinoma. (14630274)
2003
20
Primary bile duct carcinoma in histocompatibility antigen-identical twins. (12653905)
2003
21
Surgical treatment of hilar bile duct carcinoma: experience with 25 consecutive hepatectomies. (12127130)
2002
22
Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma. (11815973)
2002
23
Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: its relationship with tumor progression and prognosis. (12685548)
2002
24
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
25
Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma. (10707878)
2000
26
Establishment and characterization of human hilar bile duct carcinoma cell line and cell strain. (11180864)
2000
27
Surgical treatment and postoperative outcomes for middle and lower bile duct carcinoma in Japan--experience of a single institute. (10919005)
2000
28
ets-1 expression in extrahepatic bile duct carcinoma and cholangiocellular carcinoma. (10765128)
2000
29
Extrahepatic bile duct carcinoma: a western experience with 118 consecutive patients. (10791187)
2000
30
Limitation of cholangiography in assessing longitudinal spread of extrahepatic bile duct carcinoma to the hepatic side. (10440214)
1999
31
Liver regeneration after extended right hemihepatectomy in patients with hilar or diffuse bile duct carcinoma. (10228823)
1999
32
Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma. (9701213)
1998
33
Extended right trisegmentectomy for hilar bile duct carcinoma. (9261589)
1997
34
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma. (9369143)
1997
35
Bile duct carcinoma without jaundice: clues to early diagnosis. (9356876)
1997
36
The role of urokinase type plasminogen activator in invasion of bile duct carcinoma]. (9275473)
1996
37
Combined liver transplantation and pancreatoduodenectomy for irresectable hilar bile duct carcinoma. (8665214)
1996
38
Bile duct carcinoma arising from the anastomotic site of hepaticojejunostomy after the excision of congenital biliary dilatation: a case report. (8644016)
1996
39
Intraluminal brachytherapy in the treatment of pancreas and bile duct carcinoma. (7538501)
1995
40
Case of bile duct carcinoma of the hepatic hilus with segmental obstructive cholangitis. (8751205)
1995
41
Synchronous carcinoma of the gall-bladder in patients with bile duct carcinoma. (8031336)
1993
42
Clinicopathologic studies on perineural invasion of bile duct carcinoma. (1558415)
1992
43
Radiation therapy in extrahepatic bile duct carcinoma. (1866463)
1991
44
Preoperative TNM classification of proximal extrahepatic bile duct carcinoma by endosonography. (2162563)
1990
45
The infiltration of bile duct carcinoma along the bile duct wall. (2840410)
1988
46
Bile duct carcinoma in an adolescent. (4003379)
1985
47
Management of high bile duct carcinoma. (6203447)
1984
48
The diagnosis of primary bile duct carcinoma (cholangiocarcinoma) in the jaundiced patient. (6263536)
1981
49
Prognostic factors in bile duct carcinoma: analysis of 96 cases. (7283506)
1981
50
Bile duct carcinoma mimicking chronic liver disease. (183615)
1976

Variations for Bile Duct Carcinoma

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Expression for genes affiliated with Bile Duct Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bile Duct Carcinoma

Search GEO for disease gene expression data for Bile Duct Carcinoma.

Pathways for genes affiliated with Bile Duct Carcinoma

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51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters
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Compounds for genes affiliated with Bile Duct Carcinoma

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR
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Compounds related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aspartame46 25 1211.6TAS1R3, TAS1R2
2deoxycholic acid46 30 25 1212.1CDX2, MUC2
35-aza-2deoxycytidine468.2CDKN1C, CDX2, MUC2

GO Terms for genes affiliated with Bile Duct Carcinoma

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17Gene Ontology
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Biological processes related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of umami tasteGO:0509179.7TAS1R1, TAS1R3
2detection of chemical stimulus involved in sensory perception of sweet tasteGO:0015829.6TAS1R3, TAS1R2
3sensory perception of sweet tasteGO:0509169.4TAS1R3, TAS1R2

Molecular functions related to Bile Duct Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sweet taste receptor activityGO:0330419.4TAS1R3, TAS1R2
2protein heterodimerization activityGO:0469829.3TAS1R1, TAS1R3, TAS1R2
3taste receptor activityGO:0085279.2TAS1R1, TAS1R3, TAS1R2

Products for genes affiliated with Bile Duct Carcinoma

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Sources for Bile Duct Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet