MCID: BLD036
MIFTS: 48

Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Disease

MalaCards integrated aliases for Bile Duct Disease:

Name: Bile Duct Disease 12 14
Bile Duct Diseases 41 42 69
Bile Duct Disorder Nos 12
Disorder of Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4138
MeSH 42 D001649
NCIt 47 C96716
SNOMED-CT 64 118926004 197455006
UMLS 69 C0005395

Summaries for Bile Duct Disease

MedlinePlus : 41 your liver makes a digestive juice called bile. your gallbladder stores it between meals. when you eat, your gallbladder pushes the bile into tubes called bile ducts. they carry the bile to your small intestine. the bile helps break down fat. it also helps the liver get rid of toxins and wastes. different diseases can block the bile ducts and cause a problem with the flow of bile: gallstones, which can increase pressure in the gallbladder and cause a gallbladder attack. the pain usually lasts from one to several hours. cancer infections birth defects, such as biliary atresia. it is the most common reason for liver transplants in children in the united states. inflammation, which can cause scarring. over time, this can lead to liver failure. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Bile Duct Disease, also known as bile duct diseases, is related to cholestasis, benign recurrent intrahepatic and common bile duct disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Bile Duct Disease is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Etomidate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia : 72 A bile duct is any of a number of long tube-like structures that carry bile, and is present in most... more...

Related Diseases for Bile Duct Disease

Diseases related to Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 cholestasis, benign recurrent intrahepatic 29.8 ABCB11 ABCB4 ATP8B1 GGT1 NR1H4 SLC10A2
2 common bile duct disease 12.2
3 cholangitis 11.2
4 caroli disease 10.8
5 alport syndrome and thin basement membrane nephropathy 10.7 ABCB11 ATP8B1 NR1H4
6 cholestasis, intrahepatic, of pregnancy, 3 10.7 ABCB11 ABCB4 ATP8B1
7 cholestasis, intrahepatic, of pregnancy, 1 10.7 ABCB11 ATP8B1
8 kohler's disease 10.7 ABCB4 ALB GPT
9 bardet-biedl syndrome 6 10.6 ABCB11 ABCB4 ATP8B1
10 cholestasis, benign recurrent intrahepatic, 2 10.6 ABCB11 ABCB4 ATP8B1 NR1H4
11 congenital hypoplastic anemia 10.5 ALB GPT SLC25A13
12 malignant fibrous histiocytoma of bone 10.5 CYP7A1 NR1H4 NR1I2
13 aneurysm, intracranial berry, 9 10.5 CYP7A1 NR1H4 NR1I2
14 intussusception 10.5 ALB CCK
15 autoimmune disease of cardiovascular system 10.5 ABCB4 ALB GGT2
16 tolosa-hunt syndrome 10.5 GGT1 GGT2
17 alzheimer disease 6 10.5 ABCC2 ABCC3 ABCC4
18 anhidrosis 10.5 ABCB4 CCK
19 fallopian tube leiomyosarcoma 10.5 ABCB4 ALB CCK GPT
20 malignant visceral pleura tumor 10.4 GGT1 GGT2
21 acute cholangitis 10.4 ABCB11 ABCB4 ALB NR1I2
22 intraorbital meningioma 10.4 CCK GGT2
23 female infertility of uterine origin 10.4 ALB GPT
24 limb ischemia 10.4 GGT1 GGT2
25 noninfectious dermatoses of eyelid 10.3 ALB GGT1 GPT
26 paranasal sinus sarcoma 10.3 ALB GGT1 GPT SLC25A13
27 pyelitis 10.3 ABCC2 ALB GGT1 GPT
28 microcephaly, progressive, seizures, and cerebral and cerebellar atrophy 10.3 ABCB4 GGT1 GPT NR1I2
29 prostate cancer, progression and metastasis of 10.3 ABCB4 ALB GGT1 NR1H4
30 hereditary hemorrhagic telangiectasia 10.2 ALB GGT1 GPT SLC10A1
31 pancreatic cystadenocarcinoma 10.2 ALB GGT1 GGT2 GPT
32 chorioangioma 10.2 GGT1 GGT2
33 isthmus cancer 10.2 ABCB11 ABCB4 ALB GGT1 GPT
34 dermatomyositis 10.1 ABCB4 ALB CCK CYP7A1 GPT NR1H4
35 patent foramen ovale 10.0 ABCB11 ALB GPT NR1H4 SLC10A1 SLC10A2
36 perforation of bile duct 10.0
37 cholestasis 10.0
38 sclerosing cholangitis 9.9
39 stenosis of lacrimal punctum 9.9 GGT1 GGT2
40 tuberculum sellae meningioma 9.7 ABCB11 ALB CCK GGT1 GGT2 NR1I2
41 campylobacteriosis 9.7 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1 GPT
42 echinococcosis 9.7
43 intrahepatic cholangiocarcinoma 9.7
44 lymphoblastic lymphoma 9.7 ABCB11 ABCB4 ALB ATP8B1 GGT1 GPT
45 chronic rheumatic pericarditis 8.8 ABCB11 ABCB4 ABCC2 ALB ATP8B1 GGT1
46 eclampsia 8.2 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
47 hemorrhoid 6.5 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB
48 orbital cancer 6.4 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB

Graphical network of the top 20 diseases related to Bile Duct Disease:



Diseases related to Bile Duct Disease

Symptoms & Phenotypes for Bile Duct Disease

UMLS symptoms related to Bile Duct Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Bile Duct Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.99 SLC51B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.99 NR1I2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.99 ABCC3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.99 SLC51B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.99 SLC51B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.99 NR1I2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.99 GGT2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.99 ABCC3 GGT1 GGT2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.99 GGT2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.99 NR1I2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.99 NR1I2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.99 GGT1 GGT2 ABCB11 ABCC3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.99 ABCC3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.99 SLC51B SLC10A2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.99 SLC51B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.99 NR1I2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.99 GGT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.99 NR1I2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.99 ABCC3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.99 ABCC3 SLC51B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.99 SLC10A2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.99 NR1I2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.99 SLC51B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.99 ABCC3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.99 ABCB11
26 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.99 GGT2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.99 SLC51B
28 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.99 SLC10A2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.99 ABCB11
30 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.99 SLC10A2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.99 GGT1 GGT2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.99 SLC51B
33 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.99 SLC10A2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.99 ABCB11
35 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.99 ABCB11
36 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.99 SLC51B NR1I2 SLC10A2
37 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.99 SLC51B

MGI Mouse Phenotypes related to Bile Duct Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB
2 digestive/alimentary MP:0005381 9.7 ABCB4 ABCC4 ALB CYP7A1 CYP8B1 NR1H4
3 liver/biliary system MP:0005370 9.4 NR1H4 NR1I2 SLC10A2 SLC25A13 ABCB11 ABCB4

Drugs & Therapeutics for Bile Duct Disease

Drugs for Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 397)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etomidate Approved Phase 4 33125-97-2 36339 667484
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2 2078-54-8 4943
5
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
6
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
7
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
8
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
9
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128-13-2 31401
10
Pancrelipase Approved Phase 4,Phase 2,Phase 1 53608-75-6
11
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
12
Secretin Approved, Investigational Phase 4 108153-74-8
13
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1 443-48-1 4173
14
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
15
Meperidine Approved Phase 4 57-42-1 4058
16
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
17
Vancomycin Approved Phase 4,Phase 3,Phase 1 1404-90-6 441141 14969
18
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
19
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
20
Ofloxacin Approved Phase 4 82419-36-1 4583
21 Pinaverium Approved Phase 4 59995-65-2
22
Abatacept Approved Phase 4 332348-12-6 10237
23
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
24
Sorbitol Approved Phase 4 50-70-4 5780
25
Choline Approved, Nutraceutical Phase 4 62-49-7 305
26 Coconut Approved, Nutraceutical Phase 4
27 Tocopherol Approved, Nutraceutical Phase 4
28
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
29
Butyric Acid Experimental Phase 4 107-92-6 264
30 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Nootropic Agents Phase 4
36 Polyene phosphatidylcholine Phase 4
37 Adjuvants, Anesthesia Phase 4,Phase 3
38 Anesthetics Phase 4,Phase 3,Phase 2
39 Anesthetics, General Phase 4,Phase 2
40 Anesthetics, Intravenous Phase 4,Phase 2
41 Anti-Anxiety Agents Phase 4,Phase 3
42 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
44 Cortisol succinate Phase 4
45 GABA Agents Phase 4,Phase 3
46 GABA Modulators Phase 4
47 Hydrocortisone 17-butyrate 21-propionate Phase 4
48 Hydrocortisone acetate Phase 4
49 Hydrocortisone-17-butyrate Phase 4
50 Hypnotics and Sedatives Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 547)

id Name Status NCT ID Phase Drugs
1 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
2 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
3 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
4 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
5 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
6 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
7 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
8 Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography Unknown status NCT00155376 Phase 4 morphine and glucagon
9 Radiofrequency Ablation Versus Hepatic Resection for the Treatment of Hepatocellular Carcinomas Smaller Than 2 cm Unknown status NCT01351194 Phase 4
10 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
11 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
12 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
13 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
14 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
15 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
16 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
17 Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Completed NCT01256034 Phase 4
18 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
19 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
20 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
21 Spy II Clinical Registry Completed NCT00751998 Phase 4
22 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
23 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
24 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Recruiting NCT02605213 Phase 4 Vancomycin;Placebo
25 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Recruiting NCT02703077 Phase 4
26 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Recruiting NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
27 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
28 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
29 A Pilot Study to Characterize Bile Acid Metabolism and Dysbiosis in Primary Sclerosing Cholangitis Active, not recruiting NCT02464020 Phase 4 Vancomycin
30 Preventing Cholestasis Using SMOFLipid® Active, not recruiting NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
31 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
32 Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer Enrolling by invitation NCT01111591 Phase 4 Cox2 inhibitor (Celecoxib)
33 Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders Terminated NCT01373918 Phase 4 Intralipid;Intralipid
34 Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions Terminated NCT02633384 Phase 4
35 The INFECIR-2 Albumin Prevention Study Terminated NCT02034279 Phase 4 Albumin
36 Compare the Knob-tipped Knife With the Needle Knife in Difficult Biliary Cannulation Unknown status NCT01745978 Phase 3
37 RCT of Steroids Following Kasai Portoenterostomy for Biliary Atresia. Unknown status NCT00539565 Phase 3 prednisolone;placebo
38 Probiotics in Patients With Primary Sclerosing Cholangitis Unknown status NCT00161148 Phase 3 Probiotics
39 Minimization of IntraLipid Versus Omegaven Unknown status NCT01247012 Phase 2, Phase 3
40 Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis Unknown status NCT01398917 Phase 3
41 Comparison of Endoscopic Radiofrequency Ablation Versus Photodynamic Therapy for Inoperable Cholangiocarcinoma Unknown status NCT01739465 Phase 2, Phase 3
42 Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy Unknown status NCT00809081 Phase 3
43 RFA RCT for Pancreatic or Bile Duct Cancer Unknown status NCT02166190 Phase 3
44 Newly Designed Fully Covered Metal Stent for the Benign Biliary Stricture Completed NCT00945516 Phase 3
45 Drotaverine Hydrochloride Versus Hyoscine-N-butylbromide for Duodenal Antimotility During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT00731198 Phase 3 Drotaverine hydrochloride;Hyoscine-N-butylbromide
46 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
47 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
48 Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction Completed NCT00453076 Phase 3
49 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
50 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid

Search NIH Clinical Center for Bile Duct Disease

Cochrane evidence based reviews: bile duct diseases

Genetic Tests for Bile Duct Disease

Anatomical Context for Bile Duct Disease

MalaCards organs/tissues related to Bile Duct Disease:

39
Liver, Lung, Kidney, Pancreas, Small Intestine, Testes, Breast

Publications for Bile Duct Disease

Articles related to Bile Duct Disease:

(show all 16)
id Title Authors Year
1
CHOLANGIOSCOPY IN BILE DUCT DISEASE: a case series. ( 25296087 )
2014
2
Comparative MRI analysis of morphologic patterns of bile duct disease in IgG4-related systemic disease versus primary sclerosing cholangitis. ( 24555589 )
2014
3
Echinococcosis mimicking autoimmune or malignant bile duct disease. ( 24022203 )
2013
4
Peripheral intrahepatic cholangiocarcinoma occurring in patients without cirrhosis or chronic bile duct diseases: epidemiology and histopathology of distant nontumoral liver in 57 White patients. ( 23085575 )
2013
5
Single-operator cholangioscopy in patients requiring evaluation of bile duct disease or therapy of biliary stones (with videos). ( 21762903 )
2011
6
Biliary cytokeratin expression but not CD56 (N-CAM) expression aids in the differential diagnosis of non-neoplastic bile duct diseases. ( 20538416 )
2010
7
Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E- NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases. ( 15072822 )
2004
8
Treatment of extrahepatic bile duct disease in infancy and early childhood. ( 11847446 )
2002
9
Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period. ( 8201224 )
1994
10
Rejection of murine congenic bile ducts: a model for immune-mediated bile duct disease. ( 1537528 )
1992
11
Bile duct disease: prospective comparison of ERCP, CT, and fat suppression MRI. ( 1426853 )
1992
12
Primary sclerosing cholangitis, a vanishing bile duct disease. ( 3658059 )
1987
13
Radiomanometry in the diagnosis of common bile duct disease. ( 4445925 )
1974
14
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. ( 5058873 )
1972
15
Gallbladder and bile duct disease. ( 14392255 )
1955
16
The incidence of common bile duct disease following surgical exploration. ( 14352652 )
1955

Variations for Bile Duct Disease

Expression for Bile Duct Disease

Search GEO for disease gene expression data for Bile Duct Disease.

Pathways for Bile Duct Disease

Pathways related to Bile Duct Disease according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 ABCB11 ABCB4 ABCC3 ALB CYP7A1 CYP8B1
2
Show member pathways
13.25 ABCB4 ABCC2 ABCC3 ABCC4 ALB ATP8B1
3
Show member pathways
12.22 ABCB11 ABCC3 ALB CYP7A1 CYP8B1 NR1H4
4 11.99 ABCC2 ABCC3 ABCC4 GGT1 GGT2
5
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLC10A1 SLCO1A2
6 11.75 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
7
Show member pathways
11.73 ABCB11 ABCC2 ABCC4 SLCO1A2
8
Show member pathways
11.62 ABCC2 ABCC3 ABCC4
9 11.19 ABCC2 ABCC3 ABCC4
10 11.07 ABCC2 ABCC3 ABCC4
11 11.01 ABCB11 ABCB4 CYP7A1 CYP8B1 NR1H4 SLC10A1
12
Show member pathways
10.97 ABCC2 ABCC3 ABCC4 SLCO1A2
13 10.95 GGT1 GGT2
14 10.89 ABCC2 ABCC3 ABCC4
15 10.84 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
16 10.77 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 CYP8B1
17 10.74 ABCC3 NR1I2
18 10.67 ABCC2 NR1I2
19 10.54 ABCC2 ABCC3

GO Terms for Bile Duct Disease

Cellular components related to Bile Duct Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
2 apical plasma membrane GO:0016324 9.56 ABCB4 ABCC2 ATP8B1 SLC10A2
3 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
4 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2
5 integral component of membrane GO:0016021 10.13 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Biological processes related to Bile Duct Disease according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
2 bile acid biosynthetic process GO:0006699 9.61 ABCB11 CYP7A1 CYP8B1
3 xenobiotic transport GO:0042908 9.58 ABCB4 ABCC3 NR1I2
4 phospholipid translocation GO:0045332 9.56 ABCB4 ATP8B1
5 organic anion transport GO:0015711 9.55 ABCC2 SLCO1A2
6 bile acid metabolic process GO:0008206 9.54 ATP8B1 NR1H4
7 zymogen activation GO:0031638 9.52 GGT1 GGT2
8 glutathione catabolic process GO:0006751 9.51 GGT1 GGT2
9 drug export GO:0046618 9.49 ABCB4 NR1I2
10 response to antineoplastic agent GO:0097327 9.48 ABCB4 ABCC2
11 regulation of bile acid biosynthetic process GO:0070857 9.46 CYP7A1 NR1H4
12 drug transmembrane transport GO:0006855 9.46 ABCB4 ABCC2 ABCC3 ATP8B1
13 canalicular bile acid transport GO:0015722 9.32 ABCB11 ABCC2
14 bile acid and bile salt transport GO:0015721 9.28 ABCB11 ABCC3 ALB ATP8B1 NR1H4 SLC10A1
15 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.26 ABCB11 ABCC2 ABCC3 ABCC4
16 transport GO:0006810 10.03 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ALB

Molecular functions related to Bile Duct Disease according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.65 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
2 transporter activity GO:0005215 9.55 ABCB11 ABCC2 ABCC3 SLC25A13 SLC51B
3 organic anion transmembrane transporter activity GO:0008514 9.5 ABCC2 ABCC3 SLCO1A2
4 bile acid transmembrane transporter activity GO:0015125 9.49 SLC10A1 SLCO1A2
5 glutathione hydrolase activity GO:0036374 9.48 GGT1 GGT2
6 thyroid hormone receptor activity GO:0004887 9.46 NR1H4 NR1I2
7 xenobiotic-transporting ATPase activity GO:0008559 9.43 ABCB4 ABCC3
8 bile acid:sodium symporter activity GO:0008508 9.4 SLC10A1 SLC10A2
9 bile acid-exporting ATPase activity GO:0015432 9.37 ABCB11 ABCC3
10 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.13 ABCC2 ABCC3 ABCC4
11 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Bile Duct Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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