MCID: BLD005
MIFTS: 32

Bile Duct Mucoepidermoid Carcinoma

Categories: Cancer diseases, Oral diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Bile Duct Mucoepidermoid Carcinoma

MalaCards integrated aliases for Bile Duct Mucoepidermoid Carcinoma:

Name: Bile Duct Mucoepidermoid Carcinoma 12 14
Extrahepatic Bile Duct Mucoepidermoid Carcinoma 69
Mucoepidermoid Carcinoma of the Bile Duct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4681
NCIt 47 C5862
UMLS 69 C1332552

Summaries for Bile Duct Mucoepidermoid Carcinoma

MalaCards based summary : Bile Duct Mucoepidermoid Carcinoma, also known as extrahepatic bile duct mucoepidermoid carcinoma, is related to papilloma and situs inversus, and has symptoms including abdominal pain, icterus and nausea. An important gene associated with Bile Duct Mucoepidermoid Carcinoma is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and liver.

Related Diseases for Bile Duct Mucoepidermoid Carcinoma

Diseases related to Bile Duct Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 papilloma 10.5 MUC1 MUC4
2 situs inversus 10.4 MUC1 MUC2
3 tuberculous salpingitis 10.4 MUC1 MUC5B
4 urinary system disease 10.4 MUC1 MUC2
5 tabes dorsalis 10.4 MUC1 MUC2
6 pyloric antrum cancer 10.4 CEACAM5 MUC2
7 stricture or kinking of ureter 10.4 MUC1 MUC2
8 bronchus adenoma 10.4 KRT5 MUC1
9 pleomorphic rhabdomyosarcoma 10.4 MUC1 MUC5B
10 gastroesophageal junction adenocarcinoma 10.3 KRT5 MUC1
11 penis squamous cell carcinoma 10.3 CEACAM5 KRT5
12 bile duct clear cell adenocarcinoma 10.3 MUC2 MUC5AC
13 migraine with aura 10.3 MUC1 MUC2
14 lung squamous cell carcinoma 10.3 CEACAM5 MUC1
15 urethra clear cell adenocarcinoma 10.3 CEACAM5 KRT5
16 polysyndactyly with cardiac malformation 10.3 MUC2 MUC5AC
17 cribriform carcinoma 10.3 KRT5 MUC1
18 ureter adenocarcinoma 10.3 MUC1 MUC2
19 gastric papillary adenocarcinoma 10.3 CEACAM5 MUC1
20 anal canal squamous cell carcinoma 10.3 CEACAM5 KRT5
21 chondroblastoma 10.3 KRT5 MUC1
22 cecum adenocarcinoma 10.2 MUC1 MUC2
23 mitochondrial myopathy with lactic acidosis 10.2 KRT5 MUC1
24 sphenoid sinusitis 10.2 MUC5AC MUC5B
25 secondary syphilis 10.2 CEACAM5 MUC1
26 choriocarcinoma 10.2 MUC1 MUC2
27 testicular infarct 10.2 MUC5AC MUC5B
28 epilepsy with generalized tonic-clonic seizures 10.2 CEACAM5 MUC1
29 linitis plastica 10.2 KRT5 MUC1
30 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.1 MUC2 MUC5AC
31 tricuspid valve insufficiency 10.1 CEACAM5 MUC5AC
32 fallopian tube leiomyosarcoma 10.1 MUC1 MUC2
33 advanced sleep phase syndrome 10.1 MUC1 MUC2 MUC4
34 condrodisplasia punctata rizomélica 10.1 MUC1 MUC5AC
35 struma ovarii 10.1 MUC1 MUC2 MUC4
36 cervical adenitis 10.1 KRT5 KRT7
37 endometrial disease 10.1 KRT5 KRT7
38 acantholytic acanthoma 10.1 KRT5 KRT7
39 sebaceous adenocarcinoma 10.0 KRT5 MUC1 MUC4
40 idiopathic central precocious puberty 10.0 MUC2 MUC4 MUC5AC
41 kidney clear cell sarcoma 10.0 KRT5 KRT7
42 mucoepidermoid thyroid carcinoma 10.0 CEACAM5 KRT7
43 diffuse pulmonary fibrosis 10.0 KRT5 KRT7
44 synovitis 10.0 CEACAM5 KRT7
45 superior mesenteric artery syndrome 10.0 KRT5 KRT7
46 trachea adenoid cystic carcinoma 10.0 CEACAM5 KRT7
47 estrogen-receptor negative breast cancer 10.0 KRT5 MUC1
48 chronic neutrophilic leukemia 10.0 KRT7 MUC1
49 vulva squamous cell carcinoma 10.0 CEACAM5 KRT7
50 diffuse lipomatosis 10.0 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Bile Duct Mucoepidermoid Carcinoma:



Diseases related to Bile Duct Mucoepidermoid Carcinoma

Symptoms & Phenotypes for Bile Duct Mucoepidermoid Carcinoma

UMLS symptoms related to Bile Duct Mucoepidermoid Carcinoma:


abdominal pain, icterus, nausea, pruritus, vomiting, malaise

Drugs & Therapeutics for Bile Duct Mucoepidermoid Carcinoma

Drugs for Bile Duct Mucoepidermoid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
3 Adjuvants, Anesthesia Phase 3
4 Analgesics Phase 3
5 Analgesics, Opioid Phase 3
6 Anesthetics Phase 3
7 Anesthetics, General Phase 3
8 Anesthetics, Intravenous Phase 3
9 Central Nervous System Depressants Phase 3
10 Liver Extracts Phase 3,Phase 1,Phase 2
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Cola Nutraceutical Phase 3,Phase 1
14
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
15
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
16
Epirubicin Approved Phase 1, Phase 2 56420-45-2 41867
17 Anti-Bacterial Agents Phase 1, Phase 2
18 Antibiotics, Antitubercular Phase 1, Phase 2
19 Antimetabolites Phase 1, Phase 2
20 Antimetabolites, Antineoplastic Phase 1, Phase 2
21 Topoisomerase Inhibitors Phase 1, Phase 2
22
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
23
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
24
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
25
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
26
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
27
7-hydroxystaurosporine Experimental Phase 1 112953-11-4 72271
28
Camptothecin Experimental Phase 1 7689-03-4
29 Staurosporine Experimental Phase 1 62996-74-1
30
tipifarnib Investigational Phase 1 192185-72-1 159324
31
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
32 Adjuvants, Immunologic Phase 1
33 Albumin-Bound Paclitaxel Phase 1
34 Angiogenesis Inhibitors Phase 1
35 Angiogenesis Modulating Agents Phase 1
36 Antimitotic Agents Phase 1
37 Antineoplastic Agents, Phytogenic Phase 1
38 Interleukin-12 Phase 1
39 Protein Kinase Inhibitors Phase 1
40 topoisomerase I inhibitors Phase 1
41 Antibodies Phase 1
42 Antibodies, Monoclonal Phase 1
43
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
44 Immunoglobulins Phase 1
45 Anti-Infective Agents Phase 1
46 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2 capecitabine;carboplatin;epirubicin hydrochloride
3 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
4 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
5 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
6 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
7 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1 capecitabine;cisplatin
8 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide

Search NIH Clinical Center for Bile Duct Mucoepidermoid Carcinoma

Genetic Tests for Bile Duct Mucoepidermoid Carcinoma

Anatomical Context for Bile Duct Mucoepidermoid Carcinoma

MalaCards organs/tissues related to Bile Duct Mucoepidermoid Carcinoma:

39
Breast, Lung, Liver

Publications for Bile Duct Mucoepidermoid Carcinoma

Variations for Bile Duct Mucoepidermoid Carcinoma

Expression for Bile Duct Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Bile Duct Mucoepidermoid Carcinoma.

Pathways for Bile Duct Mucoepidermoid Carcinoma

GO Terms for Bile Duct Mucoepidermoid Carcinoma

Cellular components related to Bile Duct Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.8 CEACAM5 KRT5 MUC1 MUC2 MUC4 MUC5AC
2 extracellular exosome GO:0070062 9.7 CEACAM5 KRT5 KRT7 MUC1 MUC4 MUC5AC
3 Golgi lumen GO:0005796 9.02 MUC1 MUC2 MUC4 MUC5AC MUC5B
4 mucus layer GO:0070701 8.96 MUC5AC MUC5B

Biological processes related to Bile Duct Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.35 MUC1 MUC2 MUC4 MUC5AC MUC5B
2 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC4
3 O-glycan processing GO:0016266 9.02 MUC1 MUC2 MUC4 MUC5AC MUC5B

Sources for Bile Duct Mucoepidermoid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....