MCID: BLR013
MIFTS: 44

Biliary Tract Cancer malady

Cancer category

Summaries for Biliary Tract Cancer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial... more...

MalaCards: Biliary Tract Cancer is related to oral cancer and biliary tract disease. An important gene associated with Biliary Tract Cancer is MTAP (methylthioadenosine phosphorylase), and among its related pathways are Apoptosis Pathway and TGF Beta Signaling Pathway. The compounds crcs and 5-methylthioadenosine have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and small intestine, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Biliary Tract Cancer

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

biliary tract cancer 43 45 61


Related Diseases for Biliary Tract Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Biliary Tract Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer30.4EGFR
2biliary tract disease10.4
3wilms tumor10.4
4hepatitis c10.1
5hepatitis b10.1
6sclerosing cholangitis10.1
7cholelithiasis10.1
8bile duct adenoma10.1
9bile duct carcinoma10.1
10vascular cancer10.1
11primary sclerosing cholangitis10.1
12hepatitis c virus10.1
13hepatitis b virus infection10.1
14insulin resistance10.1
15pancreatitis10.0SMAD4
16meningioma10.0PSG2
17cholangiocarcinoma10.0PSG2, MET, MUC4, ERBB2, SMAD4
18thyroid cancer10.0MET
19endometriosis10.0PSG2
20sarcoma10.0MET, MLH1, MTAP, WNT1
21kidney cancer10.0EGFR, MET
22adenoma10.0MET, PSG2, XRCC3, TGFBR2, SMAD4, CLDN4
23gastric adenocarcinoma10.0SMAD4, ERBB2, CLDN4, MUC4, TYMS, DPYD
24leukemia10.0PSG2, MLH1, MTAP, DCTD, TYMS
25hepatocellular carcinoma10.0PSG2, MET, MTAP, DPYD, WNT1, SMAD4
26stomach cancer10.0ERBB2
27lung benign neoplasm10.0PSG2, MET, EGFR, DPYD, MUC4, SMAD4
28squamous cell carcinoma of the head and neck10.0MET, EGFR, MLH1, DPYD, TYMS, ERBB2
29non-small cell lung carcinoma10.0MET, EGFR, TYMS, MUC4, ERBB2, TGFBR2
30benign mesothelioma10.0PSG2, MET, MTAP, TYMS, WNT1
31colorectal cancer10.0PSG2, MET, EGFR, MLH1, DPYD, TYMS
32colon cancer10.0PSG2, MET, EGFR, MLH1, DPYD, TYMS
33malignant mesothelioma10.0MET, TYMS
34lung cancer10.0PSG2, MET, EGFR, TYMS, MUC4, ERBB2
35ovarian cancer10.0PSG2, MET, EGFR, MLH1, TYMS, CLDN4
36mucoepidermoid carcinoma10.0PSG2, EGFR, MUC4, TGFBR2
37retinoblastoma10.0CCNH, EGFR, TYMS, ERBB2, SMAD4, TGFBR2
38cervical cancer10.0EGFR, DPYD, TYMS, ERBB2, SMAD4, TGFBR2
39bladder carcinoma10.0XRCC3, PSG2, EGFR, MLH1, MTAP, DPYD
40melanoma10.0XRCC3, PSG2, MET, MLH1, MTAP, MUC4
41lung adenocarcinoma10.0MET, EGFR, MUC4, ERBB2, SMAD4, TGFBR2
42neutropenia10.0ERBB2, TYMS, DPYD, EGFR
43pancreatic cancer10.0TGFBR2, SMAD4, MUC4, DPYD, EGFR
44breast cancer10.0PSG2, MET, EGFR, DPYD, TYMS, MUC4
45factor vii deficiency10.0ERBB2, TYMS, EGFR, PSG2
46osteosarcoma10.0CCNH, MET, TYMS, SMAD4
47transitional cell carcinoma10.0EGFR, MLH1, DPYD, ERBB2, TGFBR2
48esophageal cancer10.0TGFBR2, SMAD4, MUC4, PSG2
49myeloma10.0PSG2, MET
50squamous cell carcinoma10.0XRCC3, PSG2, MET, TGFBR2, SMAD4, ERBB2

Graphical network of the top 20 diseases related to Biliary Tract Cancer:



Diseases related to biliary tract cancer

Clinical Features for Biliary Tract Cancer

Drugs & Therapeutics for Biliary Tract Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Biliary Tract Cancer

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Cancer

Search NIH Clinical Center for Biliary Tract Cancer

Search CenterWatch for Biliary Tract Cancer

Genetic Tests for Biliary Tract Cancer

Anatomical Context for Biliary Tract Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Biliary Tract Cancer:

33
Liver, Lymph node, Small intestine, Pancreas, Breast, Testis, T cells, B cells, Temporal lobe

Animal Models for Biliary Tract Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Biliary Tract Cancer

Sources:
51PubMed
See all sources

Articles related to Biliary Tract Cancer:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort. (23720454)
2013
2
Aberrant expression of the PHF14 gene in biliary tract cancer cells. (23833654)
2013
3
A phase II FOLFOX-4 regimen as second-line treatment in advanced biliary tract cancer refractory to gemcitabine/cisplatin. (24070164)
2013
4
Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. (23479678)
2013
5
Biliary tract cancer incidence in the United States-Demographic and temporal variations by anatomic site. (23504585)
2013
6
Photodynamic therapy for pancreatic and biliary tract cancer: the United Kingdom experience. (23055216)
2012
7
Safety and effectiveness of gemcitabine in 260 patients with biliary tract cancer in a Japanese clinical practice based on post-marketing surveillance in Japan. (23042772)
2012
8
The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer. (21946948)
2012
9
Adjuvant chemotherapy for resectable biliary tract cancer: current status and future direction. (22262202)
2012
10
Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part II: multidisciplinary management. (22488601)
2012
11
Poor evidence to standardize adjuvant treatment for patients with biliary tract cancer. (23071221)
2012
12
Trends in the incidence and management of biliary tract cancer: a French population-based study. (21056501)
2011
13
Review article: surgical, neo-adjuvant and adjuvant management strategies in biliary tract cancer. (21933219)
2011
14
A combination of serum leucine-rich I+-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures. (21970875)
2011
15
Phase 1 trial of Wilms tumor 1 (WT1) peptide vaccine and gemcitabine combination therapy in patients with advanced pancreatic or biliary tract cancer. (21150717)
2011
16
A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer. (20811895)
2011
17
Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC). (20578980)
2011
18
Time to move to targeted drugs in biliary tract cancer? (20164655)
2010
19
Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer. (19707761)
2010
20
In-hospital mortality after resection of biliary tract cancer in the United States. (20495647)
2010
21
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. (20678012)
2010
22
A step forward in the treatment of advanced biliary tract cancer. (20375411)
2010
23
Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells. (19509244)
2009
24
Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan. (19110652)
2009
25
Features of gemcitabine-related severe pulmonary toxicity: patients with pancreatic or biliary tract cancer. (19893461)
2009
26
Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. (18296645)
2008
27
Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. (18676870)
2008
28
Targeted medical therapy of biliary tract cancer: recent advances and future perspectives. (19084910)
2008
29
Prognostic relevance of carbohydrate antigen 19-9 levels in patients with advanced biliary tract cancer. (17932358)
2007
30
CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression. (17465213)
2007
31
Gallstones and the risk of biliary tract cancer: a population-based study in China. (18000509)
2007
32
Bile acid analysis in biliary tract cancer. (17191311)
2006
33
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. (16439986)
2006
34
Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: a case-cohort study. (16830349)
2006
35
CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. (16381022)
2006
36
Cryptosporidiosis of the biliary tract mimicking pancreatic cancer in an AIDS patient. (15094908)
2004
37
Mitomycin C in combination with capecitabine or biweekly high-dose gemcitabine in patients with advanced biliary tract cancer: a randomised phase II trial. (14998852)
2004
38
Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers. (15596046)
2004
39
Phase II trial of the use of gemcitabine and 5-fluorouracil in the treatment of advanced pancreatic and biliary tract cancer. (12714886)
2003
40
Self-expandable metallic stents for malignant duodenal obstruction caused by biliary tract cancer. (12872088)
2003
41
Epidemiological studies on the distribution and determinants of biliary tract cancer. (21432389)
2003
42
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. (12374683)
2002
43
Phase II trial of cisplatin, interferon alpha-2b, doxorubicin, and 5-fluorouracil for biliary tract cancer. (11705850)
2001
44
Biliary tract cancer mortality rates by prefectures in Japan. (11210170)
2000
45
Killing effects of 5-fluorouracil on human biliary tract cancer cell lines. (9917499)
1999
46
Geographic clustering patterns in mortality from biliary tract cancer in Japan. (9510468)
1998
47
Biliary tract cancer. (7534623)
1994
48
Breast cancer-associated protein pS2 expression in tumors of the biliary tract. (1928043)
1991
49
Biliary tract cancer and occupation in Sweden. (3964574)
1986
50
Adriamycin, BCNU, ftorafur chemotherapy of pancreatic and biliary tract cancer. (389404)
1979

Genetic Variations for Biliary Tract Cancer

Expression for genes affiliated with Biliary Tract Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Biliary Tract Cancer

Search GEO for disease gene expression data for Biliary Tract Cancer.

Pathways for genes affiliated with Biliary Tract Cancer

Sources:
60Tocris Bioscience, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome, 50PharmGKB, 53R&D Systems, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Biliary Tract Cancer according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MET, TGFBR2
210.5WNT1, SMAD4
310.5TGFBR2, EGFR
4
Development TGF-beta receptor signaling
Hide members
10.5TGFBR2, SMAD4, ERBB2
510.5DCTD, TYMS
610.5XRCC3, TYMS
710.4ERBB2, EGFR, MET
810.4ERBB2, EGFR, MET
910.4EGFR, MET, ERBB2
1010.4SMAD4, OCLN, TGFBR2
11
Hide members
10.4ERBB2, SMAD4, TGFBR2, EGFR
12
Hide members
10.4EGFR, ERBB2, SMAD4, MLH1
13
Translation Insulin regulation of translation
Hide members
10.4MET, TGFBR2, EGFR, ERBB2
1410.4SMAD4, ERBB2, TYMS, EGFR
15
Hide members
10.4DCTD, TYMS, DPYD
16
Hide members
10.4TYMS, DCTD, DPYD
17
Hide members
10.4DPYD, TYMS, XRCC3
1810.4TGFBR2, SMAD4, EGFR, XRCC3
1910.4WNT1, ERBB2, EGFR, MET
20
Transcription Androgen Receptor nuclear signaling
Hide members
10.4TGFBR2, ERBB2, WNT1, EGFR
21
Hide members
10.4MLH1, CCNH, DPYD, TYMS
22
Hide members
10.4MET, EGFR, ERBB2, TGFBR2, CCNH
2310.4EGFR, MET, MLH1, WNT1, ERBB2, SMAD4
2410.4CLDN2, CLDN4, OCLN, EGFR

Compounds for genes affiliated with Biliary Tract Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Biliary Tract Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1crcs4510.9MET, TGFBR2, SMAD4, DPYD, MLH1
25-methylthioadenosine4510.9ERBB2, MTAP, EGFR, TYMS
3leucovorin45 50 1112.9PSG2, EGFR, ERBB2, TYMS, DPYD
4capecitabine45 50 1112.9EGFR, TYMS, ERBB2, DPYD
5oxaliplatin45 50 1112.9DPYD, MLH1, EGFR, ERBB2, TYMS
6gemcitabine45 50 1112.9TYMS, DPYD, DCTD, EGFR, ERBB2, MLH1
7thymidine45 2411.9SMAD4, TYMS, DPYD, DCTD, MLH1, MET
8idurd4510.9TYMS, DPYD, MLH1
9thymidylate4510.9MLH1, DCTD, DPYD, TYMS, ERBB2, EGFR
10taxane4510.9ERBB2, TYMS, DPYD, EGFR
11irinotecan45 50 1112.8ERBB2, DPYD, MLH1, EGFR, TYMS
12sn 3845 6011.8DPYD, EGFR, TYMS, MLH1
13paraffin4510.8PSG2, MET, EGFR, SMAD4, ERBB2, DPYD
14agar4510.8EGFR, SMAD4, ERBB2, WNT1, MTAP, MET
15vegf4510.8MLH1, DPYD, TGFBR2, ERBB2, SMAD4, EGFR
165fluorouracil4510.8DPYD, EGFR, ERBB2, PSG2, TYMS, MLH1
17fudr4510.8PSG2, TYMS, DPYD
18progesterone45 60 29 11 2414.8CLDN4, MUC4, DPYD, MLH1, WNT1, EGFR
19carboplatin45 50 1112.8EGFR, MLH1, TYMS, ERBB2
20tegafur-uracil4510.8TYMS, DPYD
21gefitinib45 50 1112.8MET, EGFR, TYMS, ERBB2
22doxorubicin45 50 1112.8EGFR, ERBB2, PSG2, MET, TYMS, MLH1
23vinorelbine45 1111.8ERBB2, TYMS, EGFR
24eniluracil4510.8DPYD, TYMS
25folate4510.8XRCC3, MLH1, TYMS, ERBB2, DPYD
26adriamycin4510.8PSG2, TYMS
27p0024510.8PSG2, MET, MLH1, ERBB2
28cisplatin45 50 60 1113.8XRCC3, EGFR, MLH1, DPYD, TYMS, ERBB2
29paclitaxel45 50 1112.8DPYD, EGFR, MLH1, TYMS, ERBB2
30tyrosine4510.8CLDN4, MUC4, DPYD, MET, EGFR, MLH1
31docetaxel45 50 60 1113.8DPYD, ERBB2, TYMS, EGFR
32cetuximab45 50 1112.8ERBB2, TYMS, EGFR
33camptothecin45 60 1112.8DPYD, XRCC3, MLH1, TYMS
342-deoxyuridine-5-monophosphate4510.8TYMS, DPYD
35pyrimidine analogues5010.7TYMS, DPYD
36Afatinib1110.7ERBB2, EGFR
37retinoic acid45 2411.7MUC4, CCNH, MET, WNT1, EGFR, MLH1
38erlotinib45 50 1112.7TYMS, ERBB2, EGFR
39oligonucleotide4510.7SMAD4, TGFBR2, MUC4, MET, DPYD, WNT1
40topotecan45 1111.7EGFR, TYMS, ERBB2
41bvdu4510.7TYMS, DPYD
425-fluoro-2-deoxyuridine-5-monophosphate4510.6TYMS, DPYD
43pd1587804510.6EGFR, ERBB2
44serine4510.6MET, TGFBR2, CLDN4, CCNH, TYMS, EGFR
45jnj 28871063 hydrochloride6010.6EGFR, ERBB2
46iressa6010.5ERBB2, EGFR
47ag 1478 hydrochloride6010.5ERBB2, EGFR
48threonine4510.4CCNH, TGFBR2, MET, SMAD4, MTAP, MLH1
49ag 4906010.4ERBB2, EGFR
50pertuzumab45 50 1112.2EGFR, ERBB2

GO Terms for genes affiliated with Biliary Tract Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Biliary Tract Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:00592310.4CLDN2, CLDN4, OCLN
2apicolateral plasma membraneGO:01632710.1CLDN4, OCLN

Biological processes related to Biliary Tract Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pyrimidine nucleobase metabolic processGO:00620610.6DCTD, TYMS, DPYD
2organ regenerationGO:03110010.6WNT1, TYMS, TGFBR2
3pyrimidine nucleoside biosynthetic processGO:04613410.5DCTD, TYMS
4axon guidanceGO:00741110.4EGFR, SMAD4, MET, ERBB2
5nucleobase-containing small molecule metabolic processGO:05508610.4TYMS, DPYD, DCTD
6positive regulation of protein phosphorylationGO:00193410.3ERBB2, WNT1, EGFR
7DNA repairGO:00628110.1TYMS, CCNH, XRCC3, RAD23B

Molecular functions related to Biliary Tract Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.6EGFR, ERBB2
2protein phosphatase bindingGO:01990310.6MET, ERBB2, EGFR
3identical protein bindingGO:04280210.5EGFR, SMAD4, ERBB2, CLDN2, CLDN4
4receptor signaling protein tyrosine kinase activityGO:00471610.5EGFR, ERBB2
5transmembrane signaling receptor activityGO:00488810.4ERBB2, EGFR, CLDN4
6ATP bindingGO:00552410.3XRCC3, MET, EGFR, MLH1, CDK10, ERBB2
7protein tyrosine kinase activityGO:00471310.1EGFR, MET, ERBB2

Products for genes affiliated with Biliary Tract Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Biliary Tract Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet