Biliary Tract Cancer malady

Wikipedia: Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial...⁴⁴ more...

MalaCards: Biliary Tract Cancer is related to bile duct adenoma and bile duct cancer. An important gene associated with Biliary Tract Cancer is MTAP (methylthioadenosine phosphorylase), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Adherens junction. The compounds agar and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

biliary tract cancer 30 32 43

Diseases related to biliary tract cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 992)

id	Related Disease	Score	Top Affiliating Genes
1	bile duct adenoma	30.3	ERBB2, TP53, SMAD4, KRT7
2	bile duct cancer	29.3	VEGFA, CDKN2A, IL6, ERBB2, SMAD4, PSG2
3	bile duct carcinoma	28.8	KIT, MUC4, CDKN2A, CD44, CDH1, ERBB2
4	cholangiocarcinoma	23.3	KIT, SERPINA1, VIM, BRAF, VEGFA, BMP6
5	cholesterol	17.8	LRPAP1, SERPINA1, VIM, VEGFA, VCAM1, BMP6
6	hepatocellular carcinoma	16.0	KIT, BTC, SERPINA1, VIM, BRAF, VEGFA
7	pancreatitis	15.6	KIT, BTC, SERPINA1, VIM, BRAF, VEGFA
8	carcinoma	14.8	LRPAP1, KIT, BTC, SERPINA1, VIM, BRAF
9	familial prostate cancer	13.8	MLH1, ERBB2, CYP17A1, RNASEL, SHBG, EGFR
10	adenosquamous carcinoma	13.8	MUC4, MUC5AC, KRT7, EGFR
11	bronchiolo-alveolar adenocarcinoma	13.8	MUC4, MUC5AC, CDH1, KRT7, EGFR
12	thyroid medullary carcinoma	13.8	BRAF, MLH1, ERBB2, KRT7, PSG2
13	small intestine adenocarcinoma	13.7	BRAF, MUC5AC, CTNNB1, SMAD4
14	diffuse gastric cancer	13.7	XRCC3, CDH1, ERBB2, CTNNB1
15	acinar cell carcinoma	13.7	SERPINA1, CTNNB1, KRT7
16	mucoepidermoid carcinoma	13.7	MUC4, MUC5AC, NOS2, KRT7, EGFR, TGFBR2
17	tubular adenocarcinoma	13.7	MUC5AC, CDH1, ERBB2, CTNNB1, KRT7
18	microcystic adenoma	13.7	CDKN2A, CTNNB1, TGFBR2
19	intraocular melanoma	13.7	BRAF, CDKN2A, MET, ANXA5, SMAD4
20	stomach carcinoma	13.7	CDKN2A, CD44, CDH1, MLH1
21	digestive diseases	13.7	GPT, ERBB2, PPARG, PSG2, PRSS1
22	ampulla of vater carcinoma	13.6	KIT, BRAF, MUC5AC, ERBB2, KRT7, EGFR
23	lipoprotein glomerulopathy	13.6	LDLR, APOB, APOE
24	microglandular adenosis	13.6	KIT, ERBB2, EGFR
25	malignant pleural mesothelioma	13.6	MTAP, MET, TYMS, SOD2
26	defective apolipoprotein b-100	13.6	LDLR, APOB, APOE
27	familial melanoma	13.6	BRAF, CDKN2A, MGMT, IFNA1
28	acquired immunodeficiency syndrome	13.6	SERPINA1, CETP, IL16, TJP1, RNASEL, TYMS
29	hyperlipidemia type 3	13.6	LDLR, CETP, APOB, APOE
30	vasomotor rhinitis	13.6	IL10, IL13, IL16
31	cetp deficiency	13.6	LDLR, CETP, APOB, APOE
32	attenuated familial adenomatous polyposis	13.6	APEX1, PTGS2, CTNNB1, OGG1
33	cystic fibrosis lung disease	13.5	MUC5AC, MPO, IL8
34	mycetoma	13.5	IL8, CYP17A1, NOS2, CXCR2
35	myoma	13.5	CDKN2A, CTNNB1, EGFR
36	ethmoid sinusitis	13.5	MUC4, IL1B, IL4, IL8, EGFR
37	hypothyroidism	13.5	CETP, APOB, IFNA1, IFNA2, SHBG
38	gastritis	13.5	MLH1, MGMT, IL8, NOS2
39	proliferative vitreoretinopathy	13.5	BMP6, MET, TGFB1, TGFBR2
40	familial hypercholesterolemia	13.5	LDLR, CETP, APOB, APOE
41	cough variant asthma	13.5	IL10, IL4, IL5
42	papillary adenoma	13.5	VIM, KRT7, OGG1
43	oligodendroglioma	13.5	BRAF, CDKN2A, MGMT, PTEN, EGFR
44	hypereosinophilic syndrome	13.5	KIT, IL5, PDGFRB
45	eosinophilic meningitis	13.5	IL10, IL4, IL5
46	allergic conjunctivitis	13.5	IL13, IL4, IL5
47	hereditary pancreatitis	13.5	SERPINA1, MUC4, MUC5AC, APOB, SMAD4, TGFB1
48	orofacial cleft	13.5	XRCC1, XRCC3, CDH1, APEX1, NOS3, OGG1
49	pseudomyxoma peritonei	13.5	VIM, MUC5AC, CDH1, KRT7, PSG2
50	food allergy	13.4	CETP, IL13, IL4, IL5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to biliary tract cancer:

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MGI Mouse Phenotypes related to biliary tract cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	PLA2G4A, APOE
2	endocrine/exocrine gland phenotype	MP:0005379	10.5	RAD23B, LDLR, RXRB, LRPAP1
3	craniofacial phenotype	MP:0005382	10.1	RAD23B, PDGFRB, KIT, RXRA, RXRB
4	hematopoietic system phenotype	MP:0005397	9.9	SOD2, RUNX3, WNT1, CXCR2, RNASEL, KIT
5	embryogenesis phenotype	MP:0005380	9.2	KIT, VIM, BRAF, RAD23B, PARP1, XRCC1
6	other phenotype	MP:0005395	8.9	NOS2, PLA2G4A, PTGS2, IL13, APOE, SOD2
7	hearing/vestibular/ear phenotype	MP:0005377	8.7	EGFR, WNT1, SOD2, RXRB, IL13, PPARG
8	renal/urinary system phenotype	MP:0005367	8.6	PTEN, APOE, MET, INS, BRAF, KIT
9	limbs/digits/tail phenotype	MP:0005371	8.6	APOE, CTNNB1, RXRA, EGFR, OCLN, CD44
10	nervous system phenotype	MP:0003631	8.5	LRPAP1, KIT, BRAF, PARP1, LDLR, CD44
11	pigmentation phenotype	MP:0001186	8.3	RXRA, PTEN, TP53, CDKN2A, APOE, APOB
12	normal phenotype	MP:0002873	8.2	LRPAP1, SMAD4, CXCR1, RXRA, RXRB, TGFBR2
13	integument phenotype	MP:0010771	8.2	KIT, RUNX3, EGFR, BRAF, RAD23B, PARP1
14	liver/biliary system phenotype	MP:0005370	7.9	KIT, VEGFA, MTAP, INS, MET, IL6
15	immune system phenotype	MP:0005387	7.5	LDLR, RUNX3, MUC5AC, MTAP, IL6, APEX1
16	digestive/alimentary phenotype	MP:0005381	7.4	APOE, OCLN, RUNX3, TGFBR2, TGFB1, ERBB2
17	no phenotypic analysis	MP:0003012	7.2	RUNX3, PPARG, CTNNB1, PTGS2, TP53, EGFR
18	skeleton phenotype	MP:0005390	7.1	KIT, BTC, BRAF, VEGFA, BMP6, CDKN2A
19	reproductive system phenotype	MP:0005389	6.8	MLH1, CDH1, CD44, RAD23B, VEGFA, LRPAP1
20	behavior/neurological phenotype	MP:0005386	6.7	KIT, VIM, PLA2G4A, NOS2, NOS3, RXRA
21	adipose tissue phenotype	MP:0005375	6.2	INS, LDLR, RAD23B, BRAF, TGFBR2, IL6
22	mortality/aging	MP:0010768	5.8	LRPAP1, BTC, BRAF, VEGFA, VCAM1, RAD23B
23	growth/size phenotype	MP:0005378	5.6	PPARD, SMAD4, PLA2G4A, NOS3, PDGFRB, EGFR
24	tumorigenesis	MP:0002006	5.1	TNF, SOD2, PTEN, PTGS2, CTNNB1, PPARG
25	muscle phenotype	MP:0005369	4.7	BTC, VIM, BRAF, VEGFA, LDLR, MPO
26	vision/eye phenotype	MP:0005391	4.5	KIT, VIM, BRAF, VEGFA, RAD23B, LDLR
27	homeostasis/metabolism phenotype	MP:0005376	3.7	XRCC1, MPO, CDKN2A, CD44, CDH1, MLH1
28	cardiovascular system phenotype	MP:0005385	3.3	IL1B, IL6, APEX1, APOB, APOE, ERBB2
29	cellular phenotype	MP:0005384	3.2	KIT, VIM, BRAF, VEGFA, VCAM1, RAD23B

Articles related to biliary tract cancer:

(show all 44)

id	Title	Authors	Year	Affiliating Genes
1	Phase II study of S-1 combined with oxaliplatin as th erapy for patients with metastatic biliary tract cancer: influence of the CYP2A 6 polymorphism on pharmacokinetics and clinical activity. (21326246)	Kim K.P.... Kim T.W.	2011	CYP2A6
2	Active Wnt signalling is associated with low differen tiation and high proliferation in human biliary tract cancer in vitro and in vi vo and is sensitive to pharmacological inhibition. (19956832)	Kiesslich T.... Berr F.	2010	VIM, WNT1
3	Molecular targeted therapy of biliary tract cancer--r esults of the first clinical studies. (20388063)	Wiedmann M.W.... MAPssner J.	2010	EGFR, VEGFA
4	A genetic polymorphism of CYP2C19 is associated with susceptibility to biliary tract cancer. (20549256)	Isomura Y.... Koike K.	2010	CYP2C19
5	Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18- fluorodeoxyglucose PET with clinical outcome: a phase 2 study. (19932054)	Zhu A.X.... Sahani D.V.	2010	GPT
6	Cholesterol Metabolism Gene Polymorphisms and the Ris k of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China. (21062971)	Xu H.L.... Hsing A.W.	2010	LRPAP1, CETP, ABCG8
7	Thymidylate synthase and dihydropyrimidine dehydrogen ase are upregulated in pancreatic and biliary tract cancers. (19571608)	Shimoda M.... Kubota K.	2009	TYMS, DPYD
8	Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers. (19184677)	NAcmeth Z.... Schaff Z.	2009	CDH1, TJP1, OCLN
9	Claudin-1, -2, -3, -4, -7, -8, and -10 protein expression in biliary tract cancers. (18854598)	NAcmeth Z.... Schaff Z.	2009	CLDN4, CLDN2, CLDN10
10	Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. (19168589)	Park S.K.... Hsing A.W.	2009	SHBG
11	Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. (18296645)	Andreotti G.... Hsing A.W.	2008	LDLR, APOE, APOB
12	Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China. (18708406)	Zhang M.... Hsing A.W.	2008	MGMT, CCNH, RAD23B
13	Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. (18854271)	Karamitopoulou E.... Terracciano L.	2008	PTGS2
14	Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. (17984110)	Huang W.Y.... Hsing A.W.	2008	OGG1, APEX1, XRCC1
15	Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. (18676870)	Hsing A.W.... Chanock S.J.	2008	TGFB1, NOS3, PPARG
16	Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. (18375961)	Chang S.C.... Hsing A.W.	2008	RXRA, RXRB, INS
17	Prognostic significance of CD44s expression in biliary tract cancers. (18214619)	Lee S.M.... Lee S.N.	2008	CD44
18	MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. (18475301)	Matull W.R.... Pereira S.P.	2008	MUC4, MUC5AC
19	Inhibition of histone deacetylase for the treatment of biliary tract cancer: a new effective pharmacological approach. (17729398)	Bluethner T.... Wiedmann M.	2007	PARP1
20	Bile duct cyst as precursor to biliary tract cancer. (17187167)	SA... reide J.A.	2007	PTGS2
21	Restoration of RUNX3 enhances transforming growth factor-beta-dependent p21 expression in a biliary tract cancer cell line. (17470130)	Hasegawa K.... Chiba T.	2007	TGFBR2, SMAD4, RUNX3
22	Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers (18159174)	Joo H.H.... Choi Y.K.	2007	MET, ERBB2, IL6
23	CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression. (17465213)	Sato K.... Miyazaki K.	2007	MLH1
24	Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. (16820886)	Sato K.... Miyazaki K.	2006	HDAC9, DPYD
25	Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. (16439986)	Lodi C.... Schaff Z.	2006	KRT7, CLDN4
26	Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. (16361272)	Sakoda L.C.... Hsing A.W.	2006	PTGS2
27	CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. (16381022)	Hou L.... Hsing A.W.	2006	CYP17A1
28	Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. (16926628)	Wiedmann M.... Caca K.	2006	ERBB2, EGFR
29	Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. (16373701)	Karikari C.A.... Maitra A.	2005	MTAP
30	Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. (15892172)	Nakazawa K.... Ooi A.	2005	MET, ERBB2, EGFR
31	Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. (15915369)	Koga Y.... Miyazaki K.	2005	MGMT
32	Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China. (15014024)	Ueki T.... Rashid A.	2004	CDKN2A
33	The V599E BRAF mutation is uncommon in biliary tract cancers. (15181454)	Goldenberg D.... Maitra A.	2004	BRAF
34	Imatinib mesylate (STI571; Glivec)--a new approach in the treatment of biliary tract cancer? (14551510)	Wiedmann M.... Caca K.	2003	PDGFRB, KIT, ANXA5
35	Identification of novel cellular targets in biliary tract cancers using global gene expression technology. (12819026)	Hansel D.E.... Maitra A.	2003	PLA2G4A, DCTD, CTPS1
36	Allelotype analysis of the PTEN, Smad4 and DCC genes in biliary tract cancer. (12168833)	Suto T.... Nakamura S.	2002	PTEN, SMAD4
37	K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. (12374683)	Rashid A.... Hsing A.W.	2002	TGFBR2, TP53
38	Infrequent microsatellite instability in biliary tract cancer. (11223838)	Suto T.... Nakamura S.	2001	MLH1
39	Beta-catenin mutations in biliary tract cancers: a population-based study in China. (11309300)	Rashid A.... Hsing A.W.	2001	CTNNB1
40	Phase II trial of cisplatin, interferon alpha-2b, dox orubicin, and 5-fluorouracil for biliary tract cancer. (11705850)	Patt Y.Z.... Raijman I.	2001	IFNA2
41	Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells. (10842191)	Yazumi S.... Takahashi R.	2000	BMP6
42	Time-resolved immunofluorometric assay of trypsin-1 complexed with alpha(1)-antitrypsin in serum: increased immunoreactivity in patients with biliary tract cancer. (10508123)	Hedstrom J.... Stenman U.H.	1999	SERPINA1, PRSS1
43	Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers. (10425302)	Hida Y.... Katoh H.	1999	MET
44	Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. (7796400)	Yoshida S.... Uchida K.	1995	TP53, IFNA1

Genes related to biliary tract cancer according to GeneCards:

(show top 50)    (show all 86)

id	Symbol	Description	Score	GeneCards Section Context
1	MTAP	methylthioadenosine phosphorylase	11.0	Publications
2	MUC4	mucin 4, cell surface associated	11.0	Publications
3	SMAD4	SMAD family member 4	11.0	Publications
4	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0
5	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
6	DPYD	dihydropyrimidine dehydrogenase	11.0	Publications
7	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
8	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
9	TYMS	thymidylate synthetase	11.0	Publications
10	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
11	EGFR	epidermal growth factor receptor	11.0	Publications
12	CLDN4	claudin 4	11.0	Publications
13	CLDN2	claudin 2	11.0	Publications
14	DCTD	dCMP deaminase	11.0	Publications
15	PRSS1	protease, serine, 1 (trypsin 1)	11.0	Publications
16	OCLN	occludin	11.0	Publications
17	CCNH	cyclin H	11.0	Publications
18	WNT1	wingless-type MMTV integration site family, member 1	11.0	Publications
19	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	11.0	Publications
20	RUNX3	runt-related transcription factor 3	11.0	Publications
21	RAD23B	RAD23 homolog B (S. cerevisiae)	11.0	Publications
22	LRPAP1	low density lipoprotein receptor-related protein associated protein 1	11.0	Publications
23	CLDN10	claudin 10	11.0	Publications
24	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	11.0	Publications
25	RXRB	retinoid X receptor, beta	11.0	Publications
26	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
27	ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	11.0	Publications
28	BTC	betacellulin	11.0
29	CXCR2	chemokine (C-X-C motif) receptor 2	11.0	Publications
30	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
31	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
32	TJP1	tight junction protein 1	11.0	Publications
33	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
34	KRT7	keratin 7	11.0	Publications
35	IL16	interleukin 16	11.0	Publications
36	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
37	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0	Publications
38	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
39	RXRA	retinoid X receptor, alpha	11.0	Publications
40	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
41	PPARD	peroxisome proliferator-activated receptor delta	11.0	Publications
42	SHBG	sex hormone-binding globulin	11.0	Publications
43	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
44	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	11.0	Publications
45	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
46	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
47	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0	Publications
48	ANXA5	annexin A5	11.0	Publications
49	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
50	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications

Pathways related to biliary tract cancer according to GeneDecks:

(show top 50)    (show all 149)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.7	IL16, RXRA
2	Adherens junction20	10.0	SMAD4, CDH1, TGFBR2, EGFR, MET, ERBB2
3	ILK Signaling36	9.8	PTGS2, CTNNB1, KIT, BTC, EGFR, VIM
4	IL-6 Pathway36	9.6	IL8, BMP6, IL16, IL4, IL10, BRAF
5	NFAT Signaling and Lymphocyte Interactions36	9.5	IL13, IL4, IL5, IL1A, IL16, BMP6
6	Endometrial cancer20	9.4	CTNNB1, TP53, CDH1, EGFR, ERBB2, MLH1
7	Thyroid cancer20	9.4	TP53, CDH1, PPARG, RXRA, RXRB, BRAF
8	Epithelial Adherens Junctions36	9.3	CDH1, EGFR, CTNNB1, PTEN, TJP1, ERBB2
9	Melanoma20	9.2	BRAF, PDGFRB, EGFR, PTEN, TP53, MET
10	Selected targets of GCR-alpha10	9.2	CYP2C19, IL4, IL1B, INS, MGMT, IL6
11	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	IL1B, IL13, IL5, IL6, TGFB1, IL4
12	Nanog in Mammalian ESC Pluripotency36	9.2	PDGFRB, EGFR, TGFB1, CTNNB1, BTC, BRAF
13	Regulation of eIF4 and p70S6K36	9.2	IL1A, IL6, IL5, IL4, IL16, IL13
14	PGC1Alpha Pathway36	9.2	IL5, BMP6, IL16, IL1A, IL1B, IL4
15	Bladder cancer20	9.1	ERBB2, BRAF, EGFR, TP53, CDH1, IL8
16	Sertoli-Sertoli Cell Junction Dynamics36	8.9	CTNNB1, CLDN2, CLDN4, CLDN10, CDH1, BRAF
17	Estrogen Pathway36	8.7	HDAC9, BTC, KIT, BRAF, BMP6, MET
18	Pathways in cancer20	8.6	EGFR, CTNNB1, RXRB, RXRA, NOS2, SMAD4
19	Akt Signaling36	8.6	PDGFRB, TNF, KIT, BTC, MET, IL10
20	PPAR Pathway36	8.6	PPARG, RXRA, PDGFRB, KIT, EGFR, BTC
21	Pancreatic Adenocarcinoma36	8.5	PDGFRB, PTGS2, TP53, ERBB2, IL6, CDKN2A
22	p53 Mediated Apoptosis36	8.4	PTEN, TP53, IL6, TGFB1, KIT, BTC
23	Malaria20	8.4	VCAM1, TNF, MET, TGFB1, IL10, IL1B
24	Rho Family GTPases36	8.3	VIM, BTC, IL1A, BMP6, CDH1, MET
25	Hepatitis C20	8.2	BRAF, CLDN2, CLDN4, CLDN10, IL8, IFNA1
26	Molecular Mechanisms of Cancer36	8.2	IL6, IL5, IL16, IL13, MET, CDH1
27	Leishmaniasis20	8.1	IL1B, IL10, IL1A, IL4, TNF, NOS2
28	Colorectal Cancer Metastasis36	8.1	TGFBR2, WNT1, TGFB1, EGFR, CTNNB1, PTGS2
29	Endothelin-1 Signaling Pathway36	8.1	KIT, BRAF, BMP6, IL10, IL13, IL16
30	Glucocorticoid Receptor Signaling36	8.0	HDAC9, BMP6, IL1A, IL8, IL6, IL5
31	TGF-Beta Pathway36	8.0	MET, IL6, IL8, EGFR, IL5, IL4
32	Apoptotic Pathways in Synovial Fibroblasts36	8.0	KIT, EGFR, PDGFRB, TP53, IL6, MET
33	Immune response MIF in innate immunity response10	8.0	IL1B, IL6, IL8, TP53, TNF, PTGS2
34	Immune response_MIF in innate immunity response41	7.9	TP53, IL8, IL6, PTGS2, NOS2, IL1B
35	SOCS Pathway36	7.9	IL1A, IL1B, IL4, IL5, IL6, IL8
36	Cellular Apoptosis Pathway36	7.9	TNF, MET, CDKN2A, IL6, TP53, KIT
37	ERK Signaling36	7.8	EGFR, KIT, BTC, IL4, BRAF, TGFB1
38	MIF Regulation of Innate Immune Cells36	7.4	IL5, IL8, TNF, PTGS2, IL4, IL1B
39	MIF Mediated Glucocorticoid Regulation36	7.4	IL13, BMP6, IL8, IL6, TNF, IL4
40	all-trans-Retinoic Acid Signaling in Brain36	7.3	IL1B, IL16, IL5, IL6, IL8, PTGS2
41	JAK-STAT Pathway36	7.3	IL1A, IL16, IL13, IL10, MET, BMP6
42	STAT3 Pathway36	7.3	BRAF, MET, IL10, IL13, IL16, BMP6
43	Cytokine Network36	7.3	TNF, IFNA2, IFNA1, IL8, IL6, IL5
44	PEDF Induced Signaling36	7.3	IL4, BRAF, BMP6, IL8, IL13, IL16
45	Tec Kinases Signaling36	7.2	IL13, IL8, TNF, PDGFRB, ERBB2, EGFR
46	MAPK Family Pathway36	7.1	TGFBR2, TGFB1, EGFR, IL6, IL5, IL8
47	PAK Pathway36	7.0	BMP6, IL13, IL10, MET, BTC, KIT
48	Antioxidant Action of Vitamin-C36	6.8	KIT, TNF, EGFR, IL1A, IL1B, IL4
49	p38 Signaling36	6.3	IL10, IL5, IL4, IL1B, IL1A, IL16
50	Cytokine-cytokine receptor interaction20	6.2	IL8, IL6, IL5, IL4, IL1B, IL1A

Compounds related to biliary tract cancer according to GeneDecks:

(show top 50)    (show all 462)

id	Compound	Score	Top Affiliating Genes
1	agar32	10.0	HDAC9, WNT1, PDGFRB, SMAD4, CTNNB1, ERBB2
2	hyaluronic acid32 18	10.6	HDAC9, PTEN, GPT, IL13, CDH1, CD44
3	vitamin a32 9 18 9	12.3	KRT7, RXRA, CTNNB1, CYP17A1, IFNA2, GPT
4	retinoid32	9.1	EGFR, SHBG, KRT7, RXRB, RXRA, PPARD
5	azathioprine32 34 9 9	12.1	VIM, CDKN2A, CD44, HDAC9, DPYD, NOS3
6	pge232	9.0	IL1A, IL13, CDH1, MUC5AC, LDLR, VCAM1
7	rapamycin32 42	10.0	KIT, VIM, EGFR, PDGFRB, PLA2G4A, MET
8	pioglitazone32 9 9	11.0	SHBG, PPARG, CYP17A1, CYP2C19, PTGS2, GPT
9	calcitriol32 42 9 18 9	12.9	HDAC9, SOD2, SHBG, PDGFRB, RXRA, PPARD
10	chloramphenicol32 9 9	10.9	VIM, LDLR, CETP, RXRA, SMAD4, CYP17A1
11	progesterone32 42 9 18 9	12.9	HDAC9, WNT1, DPYD, TGFBR2, EGFR, KRT7
12	5-aza-2deoxycytidine32	8.8	CTNNB1, PTEN, TP53, IFNA1, MGMT, MLH1
13	phosphatidylinositol32	8.7	WNT1, CXCR2, CXCR1, EGFR, PDGFRB, NOS3
14	h2o232	8.7	IL5, IL13, MPO, LDLR, SERPINA1, APEX1
15	temozolomide32 9 9	10.5	PARP1, VEGFA, VIM, XRCC1, CDKN2A, EGFR
16	ns 39832 42	9.4	PLA2G4A, PPARD, TNF, IL8, IL1B, IL1A
17	thymidylate32	8.4	XRCC1, VEGFA, VIM, DCTD, DPYD, TYMS
18	matrigel32	8.4	VCAM1, VEGFA, BRAF, VIM, BTC, BMP6
19	gemcitabine32 34 9 9	11.2	HDAC9, DCTD, DPYD, TYMS, EGFR, PDGFRB
20	cysteine32	8.1	MGMT, CDH1, CD44, CDKN2A, MUC5AC, LDLR
21	ciglitazone32	8.1	PPARG, PTGS2, PTEN, TNF, IL8, IL6
22	oxygen32 18	9.0	RNASEL, NOS3, NOS2, PPARD, CYP17A1, CYP2C19
23	fenofibrate32 9 9	10.0	NOS3, PPARD, PPARG, TNF, GPT, APOB
24	oligonucleotide32	7.9	TGFBR2, BMP6, BRAF, VIM, SERPINA1, KIT
25	atorvastatin32 34 9 18 9	11.8	VEGFA, VCAM1, SHBG, NOS3, PPARG, CYP2C19
26	testosterone32 9 18 9	10.8	CYP2C19, CYP2A6, PTEN, ERBB2, APOE, IL5
27	5fluorouracil32	7.5	VEGFA, KIT, CTNNB1, PTEN, TP53, ERBB2
28	tgf beta132	7.3	VCAM1, VIM, BMP6, CDH1, HDAC9, TGFBR2
29	prednisolone32 9 9	9.3	IL13, IL10, CD44, MPO, BMP6, VCAM1
30	rosiglitazone32 9 18 9	10.2	NOS3, PPARD, PPARG, CYP17A1, CYP2C19, CYP2A6
31	glutamine32	7.1	IL5, IL1A, IL13, CDH1, CETP, XRCC1
32	gm-csf32	7.0	TGFB1, TNF, IL8, IL6, IL5, IL4
33	sb 20358032 42	7.9	VEGFA, BRAF, VIM, VCAM1, BMP6, HDAC9
34	simvastatin32 34 42 9 18 9	11.9	LDLR, BMP6, VCAM1, VEGFA, SHBG, NOS3
35	15-deoxy-delta-12,14-prostaglandin j232	6.9	NOS3, NOS2, PPARD, PPARG, CYP17A1, PTGS2
36	hydrocortisone32 9 9	8.9	IL1A, IL13, IL10, INS, BMP6, VIM
37	tamoxifen32 34 9 9	9.7	HDAC9, SOD2, TGFBR2, TYMS, EGFR, SHBG
38	lactate32	6.5	SOD2, PSG2, TGFB1, TYMS, SHBG, SMAD4
39	pdtc32	6.5	SOD2, TGFB1, NOS2, PPARG, PTGS2, TNF
40	nitric oxide32 9 18 9	9.4	CXCR2, IL16, IL13, IL10, MET, MGMT
41	paraffin32	6.3	PTEN, MUC5AC, VCAM1, VEGFA, BRAF, VIM
42	ly29400232	6.2	IL1B, IL13, IL10, CDH1, CD44, VEGFA
43	pd 98,05932	6.2	HDAC9, IL13, MET, CDH1, MUC5AC, PARP1
44	vegf32	6.0	SOD2, PTGS2, TJP1, TP53, ERBB2, APOE
45	curcumin32	5.4	TP53, ERBB2, ANXA5, IL8, IL6, IL1B
46	thymidine32 18	6.4	CTNNB1, CYP17A1, TNF, TP53, IFNA2, IFNA1
47	tyrosine32	5.3	CYP17A1, CYP2C19, PTEN, TJP1, ERBB2, IFNA2
48	actinomycin d32	4.7	SOD2, CXCR1, TGFBR2, TGFB1, NOS3, NOS2
49	serine32	3.9	LRPAP1, CXCR2, OGG1, PRSS1, TGFBR2, TGFB1
50	cycloheximide32	3.0	SOD2, CXCR1, TGFBR2, TGFB1, TYMS, EGFR

Cellular components related to biliary tract cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apical part of cell	GO:045177	9.8	VCAM1, TJP1, CTNNB1, NOS3, CDH1
2	external side of plasma membrane	GO:009897	8.6	TGFBR2, TNF, ANXA5, IL4, IL13, CD44
3	nucleoplasm	GO:005654	8.6	PPARD, RAD23B, OGG1, TYMS, RXRB, RXRA
4	cell surface	GO:009986	8.2	WNT1, CXCR2, TGFB1, TNF, IL1A, CDH1
5	plasma membrane	GO:005886	7.2	CDH1, BTC, EGFR, KIT, LRPAP1, APOE
6	extracellular region	GO:005576	6.8	LRPAP1, IL8, BTC, SERPINA1, VEGFA, CETP
7	cytosol	GO:005829	6.6	OCLN, CTPS1, PPARG, SMAD4, PLA2G4A, NOS3
8	nucleus	GO:005634	6.2	RAD23B, PARP1, APEX1, TGFB1, OGG1, RUNX3
9	cytoplasm	GO:005737	6.2	IL13, IL16, APEX1, APOB, APOE, ANXA5
10	extracellular space	GO:005615	4.8	PRSS1, IL1A, IL16, IL13, IL10, MET

Biological processes related to biliary tract cancer according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular component disassembly involved in apoptotic process	GO:006921	10.3	CDH1, VIM, OCLN, CTNNB1, TJP1
2	response to vitamin D	GO:033280	10.2	TGFB1, RXRA, PLA2G4A, PTGS2, IL1B
3	response to cytokine stimulus	GO:034097	10.1	SERPINA1, CTNNB1, PTGS2, IL4, NOS3, CYP17A1
4	cholesterol homeostasis	GO:042632	10.1	CETP, APOB, LDLR, APOE, ABCG8
5	negative regulation of protein catabolic process	GO:042177	10.1	EGFR, INS, SMAD4, NOS2
6	cholesterol metabolic process	GO:008203	10.0	CETP, IL4, APOB, APOE, LDLR, RXRA
7	DNA repair	GO:006281	10.0	OGG1, XRCC3, RAD23B, PARP1, XRCC1, TYMS
8	positive regulation of cell migration involved in sprouting angiogenesis	GO:090050	10.0	HDAC9, PTGS2, VEGFA
9	response to estradiol stimulus	GO:032355	9.9	IL1B, PTGS2, NOS3, CTNNB1, TGFB1, SERPINA1
10	positive regulation vascular endothelial growth factor production	GO:010575	9.9	IL1A, PTGS2, TGFB1, IL1B
11	phospholipid transport	GO:015914	9.9	LDLR, CETP, ABCG8
12	aging	GO:007568	9.9	TGFB1, RXRA, NOS3, PLA2G4A, VCAM1, IL1B
13	response to organic cyclic compound	GO:014070	9.8	MET, SERPINA1, CYP17A1, OCLN, RXRA, NOS3
14	lipid metabolic process	GO:006629	9.8	LDLR, CETP, PPARG, PPARD, ABCG8, APOB
15	negative regulation of acute inflammatory response	GO:002674	9.8	INS, IL4, PPARG
16	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.7	TNF, IL1B, CD44
17	base-excision repair	GO:006284	9.7	XRCC1, TP53, OGG1, PARP1, APEX1
18	positive regulation of fever generation	GO:031622	9.6	PLA2G4A, IL1B, PTGS2, TNF
19	positive regulation of cell division	GO:051781	9.5	VEGFA, TGFB1, IL1B, IL1A, BTC
20	in utero embryonic development	GO:001701	9.4	TP53, NOS3, APOB, CTNNB1, TGFBR2, SMAD4
21	wound healing	GO:042060	9.4	IL1B, PPARD, ERBB2, IL1A, INS
22	positive regulation of MAP kinase activity	GO:043406	9.3	VEGFA, ERBB2, TNF, PDGFRB, EGFR, TGFB1
23	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IL1B, INS, EGFR, PTGS2, TNF
24	positive regulation of gene expression	GO:010628	9.2	KIT, VEGFA, CD44, MET, BRAF, TGFB1
25	cellular response to organic cyclic compound	GO:071407	9.2	CTNNB1, TNF, TGFB1, IL1B, MGMT, PPARG
26	positive regulation of protein phosphorylation	GO:001934	9.1	VEGFA, ERBB2, WNT1, TGFB1, TNF, IL1B
27	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.1	PDGFRB, TNF, IL1B, IL1A, CD44, BRAF
28	protein kinase B signaling cascade	GO:043491	9.0	TNF, TGFB1, IL1B, PTEN
29	positive regulation of mitosis	GO:045840	9.0	MET, PDGFRB, INS, IL1A, TNF, IL1B
30	positive regulation of smooth muscle cell proliferation	GO:048661	9.0	PDGFRB, IL13, IL6, TNF, PTGS2
31	induction of apoptosis	GO:006917	8.8	TNF, APOE, CDKN2A, TGFB1, PPARG, PTEN
32	cytokine-mediated signaling pathway	GO:019221	8.8	IFNA2, IL6, RNASEL, IL5, IL1B, IL1A
33	response to glucocorticoid stimulus	GO:051384	8.7	RXRA, PLA2G4A, TNF, IL6, IL1B, IL10
34	positive regulation of cytokine secretion	GO:050715	8.7	INS, IL10, TNF, IL1A
35	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.6	TGFB1, CD44, VEGFA, BRAF, MET, IL6
36	positive regulation of apoptotic process	GO:043065	8.5	CTNNB1, PLA2G4A, NOS3, PTGS2, RXRA, IL1B
37	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.5	TP53, IL6, VEGFA, CD44, INS, IL5
38	positive regulation of cell proliferation	GO:008284	8.4	INS, BTC, IL6, PTEN, VEGFA, WNT1
39	anti-apoptosis	GO:006916	8.4	IL10, TNF, NOS3, BRAF, MPO, APOE
40	response to hypoxia	GO:001666	8.2	IL1A, XRCC1, SERPINA1, VCAM1, TGFB1, IL1B
41	small molecule metabolic process	GO:044281	8.1	CD44, PTEN, PTGS2, CYP2A6, CYP2C19, CYP17A1
42	negative regulation of transcription, DNA-dependent	GO:045892	8.1	PPARG, HDAC9, PPARD, TNF, TP53, IFNA2
43	apoptotic process	GO:006915	7.9	TNF, TP53, IL1B, IL1A, VIM, CDH1
44	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	7.9	IL4, WNT1, PPARG, PTEN, TNF, IL6
45	response to drug	GO:042493	7.9	TGFBR2, IL10, CDH1, TGFB1, NOS3, PPARG
46	positive regulation of transcription, DNA-dependent	GO:045893	7.2	IL6, TP53, TNF, CTNNB1, PPARG, PPARD
47	negative regulation of apoptotic process	GO:043066	7.1	TNF, EGFR, SOD2, CD44, WNT1, BRAF
48	negative regulation of cell proliferation	GO:008285	7.0	TGFB1, NOS3, SMAD4, CTNNB1, PTGS2, PTEN
49	inflammatory response	GO:006954	6.7	CXCR2, IL1B, KIT, BMP6, CXCR1, IL10
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	RNASEL, TGFB1, RXRA, RXRB, TNF, PPARG

Molecular functions related to biliary tract cancer according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.0	PPARD, RXRA, RXRB, PPARG
2	receptor signaling protein tyrosine kinase activity	GO:004716	9.9	EGFR, ERBB2, KIT
3	heme binding	GO:020037	9.5	NOS2, MPO, PTGS2, CYP2A6, CYP2C19, CYP17A1
4	enzyme binding	GO:019899	8.7	CYP2C19, CYP2A6, PTGS2, CTNNB1, PPARG, RXRA
5	identical protein binding	GO:042802	8.7	CLDN4, SMAD4, EGFR, TNF, TP53, ERBB2
6	protein heterodimerization activity	GO:046982	8.6	MET, BMP6, BRAF, VEGFA, TGFB1, APOB
7	transcription regulatory region DNA binding	GO:044212	8.6	TP53, CTNNB1, TNF, PPARG, SMAD4, RXRA
8	growth factor activity	GO:008083	8.4	BTC, VEGFA, BMP6, IL1B, IL4, IL5
9	protease binding	GO:002020	8.2	INS, SERPINA1, TNF, KIT, TP53
10	cytokine activity	GO:005125	6.8	IL16, IL10, IL13, IL6, IL1A, IL1B
11	protein binding	GO:005515	2.9	TNF, CTNNB1, PTEN, IL4, IL5, IL8