MCID: BLR006
MIFTS: 49

Biliary Tract Disease malady

Gastrointestinal diseases category

Summaries for Biliary Tract Disease

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32MalaCards
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MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to pancreatitis and acute pancreatitis. An important gene associated with Biliary Tract Disease is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Drug Induction of Bile Acid Pathway. The compounds pregnanedione and androstanol have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Biliary Tract Disease

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

biliary tract disease 8
biliary tract diseases 60


External Ids:

Disease Ontology8 DOID:9741
ICD9CM27 576.9
NCIt39 C2899
MeSH34 D001660
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Clinical Features for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Biliary Tract Disease

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Search CenterWatch for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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32MalaCards
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MalaCards organs/tissues related to Biliary Tract Disease:

32
Liver, Testes, Heart, Lung, Testis, T cells

Animal Models for Biliary Tract Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Biliary Tract Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7KRT19
2MP:00053898.2NR1I2, NR1I3, NR1H2, KRT19, TERT
3MP:00053707.9SOD1, NR1I2, NR1I3, NR1H2, NR1H4, INS
4MP:00053817.5SPINK1, TERT, KRT19, INS, GAST
5MP:00053877.2SOD1, GAST, NR1H2, NR1H4, INS, TERT
6MP:00053797.0SOD1, GAST, NR1H2, INS, KRT19, TERT
7MP:00053766.8SOD1, GAST, NR1I2, NR1I3, NR1H2, NR1H4
8MP:00053846.6SOD1, NR1I2, NR1I3, NR1H2, NR1H4, INS
9MP:00107686.0SPINK1, SOD1, GAST, NR1I2, NR1I3, NR1H2

Publications for Biliary Tract Disease

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50PubMed
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Articles related to Biliary Tract Disease:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Predominant association of Raoultella bacteremia with diseases of the biliary tract. (24325334)
2014
2
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
3
Impact of an acute care surgery model with a dedicated daytime operating room on outcomes and timeliness of care in patients with biliary tract disease. (23756774)
2013
4
Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases. (22253524)
2012
5
Peroral cholangioscopy for diagnosis and therapy of biliary tract disease using an ultra-slim gastroscope. (21823068)
2011
6
Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children. (20101777)
2010
7
Lymphoplasmacytic chronic cholecystitis and biliary tract disease in patients with lymphoplasmacytic sclerosing pancreatitis. (12657928)
2003
8
Helicobacter pylori and the risk of benign and malignant biliary tract disease. (12879485)
2003
9
MR and ultrasound in screening of patients with suspected biliary tract disease. (11972468)
2002
10
The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. (10222553)
1999
11
Gallbladder and biliary tract disease in AIDS. (9187927)
1997
12
Laparoscopic management of complicated biliary tract disease in children. (8808562)
1996
13
The utility of the CCK DISIDA scan in the treatment of occult biliary tract disease. (7887533)
1995
14
Revised estimates of diagnostic test sensitivity and specificity in suspected biliary tract disease. (7979854)
1994
15
Biliary tract disease in the aged. (1855163)
1991
16
Hospitalizations for biliary tract disease, 1990. (1763278)
1991
17
Endoscopic retrograde sphincterotomy in the treatment of biliary tract disease. (3389588)
1988
18
Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiography. Report of a case without biliary tract disease. (3304890)
1987
19
Current attitudes in the management of obstructive biliary tract disease. (3082266)
1986
20
Choledochoduodenostomy in the treatment of benign biliary tract disease. (3739506)
1986
21
Biliary excretion of aztreonam in patients with biliary tract disease. (6539092)
1984
22
Obstructive biliary tract disease. (7051569)
1982
23
Endoscopic papillotomy in the geriatric patient with complicated biliary-tract disease. (7462544)
1981
24
Acute biliary tract disease associated with echovirus 11 infection. (7256335)
1981
25
Endoscopic papillotomy in the treatment of biliary tract disease: 258 procedures and results. (7307851)
1981
26
Application of gray-scale ultrasonography in the patient with suspected biliary tract disease. (6995023)
1980
27
Pancreatic abscess and its relation to biliary tract disease. (7429805)
1980
28
Endoscopic papillotomy in the high-risk and aging patient with biliary tract disease. (7347368)
1980
29
Pancreatic enzyme levels in bile of patients with extrahepatic biliary tract disease. (434320)
1979
30
Endoscopic sphincterotomy in the management of biliary tract disease. (581750)
1978
31
Routine preoperative upper gastrointestinal series (UGIS) in patients with biliary tract disease: a plea for more selectivity. (888099)
1977
32
Route of infection in extrahepatic biliary tract disease. II: Bacterial recovery from gallbladder bile and gallbladder wall in human biliary tract disease. (1064133)
1976
33
Biliary tract disease and sickle cell anaemia in Korle Bu Teaching Hospital, Accra. (1234677)
1975
34
Endoscopic pancreatocholangiography in the diagnosis of biliary tract disease. (4591875)
1973
35
Biliary-tract disease in Malaya. (5124853)
1971
36
Biliary tract disease in sickle cell anemia: surgical considerations. (5098228)
1971
37
Pancreatic cystadenoma and biliary tract disease. (5504218)
1970
38
Calculous biliary tract disease. (5763325)
1969
39
Indications for operation in biliary tract disease among the elderly. (5797468)
1969
40
The mortality and morbidity of surgery or biliary tract disease. (4239025)
1969
41
The significance of biliary tract disease in the diabetic--its unique features. (13948816)
1963
42
Mitral stenosis and biliary tract disease. (13828428)
1960
43
Intravenous cholangiography in biliary tract disease. (14407448)
1960
44
Progress in gallbladder and biliary tract disease. (13626913)
1959
45
Experience with unusual biliary tract disease. (13631460)
1959
46
Medical problems in biliary tract disease. (13545215)
1958
47
Reevaluation. IX. Problems in the management of biliary tract disease. (13469761)
1957
48
Biliary tract disease. (13365291)
1956
49
The electrocardiogram in biliary tract disease and during experimental biliary distention; clinical observations on 26 patients. (18910943)
1948
50
Oration in Surgery: Indications for Operation in Biliary Tract Disease. (20893002)
1941

Genetic Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Biliary Tract Disease

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Sources:
28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pregnanedione2810.2NR1I3, NR1I2
2androstanol4410.2NR1I3, NR1I2
3androstenol4410.0NR1I2, NR1I3
4t 09013175910.0NR1H2, NR1H4
5gw 3965 hydrochloride5910.0NR1H2, NR1H4
6fexaramine59 28 1112.0NR1H2, NR1H4
77alpha-hydroxy-4-cholesten-3-one449.9NR1H2, NR1I2
8citco44 2810.8NR1H2, NR1I2, NR1I3
9dmes449.8NR1H2, NR1I3, NR1I2
10N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE119.8NR1H2, NR1I2
11gw 406444 5910.8NR1H4, NR1H2, NR1I2
12steroidal449.7NR1H4, NR1I3, NR1H2
13pregnane449.7NR1I3, NR1I2
14lg 100268449.7NR1H4, NR1H2
15ursodeoxycholic acid44 11 2411.7NR1H2, NR1H4, NR1I2
16rifampicin44 28 5911.7NR1H2, NR1I3, NR1I2
17omeprazole44 28 49 11 2413.6GAST, NR1I3, NR1I2
18calcium gluconate449.6INS, GAST
19tocopherol449.6NR1I2, NR1H2, SOD1
20taurocholate449.5NR1H2, NR1H4, GAST
21lithocholic acid44 28 2411.5NR1I3, NR1I2, NR1H2, NR1H4
22androstane449.5NR1I2, NR1H2, NR1H4, NR1I3
23chenodeoxycholic acid44 28 11 2412.5NR1H2, NR1H4, NR1I2, NR1I3
24sterol449.4NR1H4, NR1H2, NR1I3, NR1I2
25phenobarbital44 28 1111.4NR1H2, NR1I2, NR1I3
26betacarotene449.4NR1H2, NR1I2, SOD1
27smcc449.4KRT19, NR1H2
28dhea449.2INS, NR1H4, NR1I3, NR1I2
29dexamethasone44 49 28 1112.2NR1I3, NR1I2, NR1H2, INS
30arsenite44 2410.1NR1I2, SOD1, TERT, NR1H2
31paclitaxel44 49 1111.0TERT, NR1I3, KRT19
32acetaminophen44 2 49 11 2413.0GAST, NR1I2, NR1I3
33hydrocortisone44 2 59 1112.0INS, GAST, NR1H2, NR1I2
34thyroxine44 2410.0INS, NR1H2, NR1I2, GAST
35vitamin d448.9NR1H4, NR1H2, NR1I3, NR1I2, GAST
36retinoid448.8NR1I2, NR1H4, NR1H2, KRT19
37steroid448.8NR1H2, NR1I3, NR1H4, KRT19
38glucose448.8NR1I2, KRT19, GAST, NR1H4
39cholesterol44 28 11 2411.7NR1H4, INS, NR1H2, NR1I2, NR1I3
40progesterone44 59 28 11 2412.5KRT19, NR1I3, NR1H4, NR1I2, NR1H2
41calcitriol44 59 11 2411.5TERT, NR1H4, NR1H2, NR1I2, GAST, NR1I3
42cisplatin44 49 59 1111.2KRT19, NR1I2, SOD1, GAST, TERT
43arginine448.2SOD1, NR1I3, NR1H2, TERT, INS, NR1H4
44retinoic acid44 249.1NR1H4, KRT19, NR1H2, TERT, NR1I3, NR1I2
45thymidine44 249.1NR1I2, GAST, TERT, KRT19, NR1H4, NR1I3
46creatinine448.1INS, KRT19, SPINK1, SOD1, GAST
47lipid447.8INS, NR1H4, SOD1, TERT, NR1H2, NR1I3
48tyrosine447.4TERT, NR1I2, KRT19, GAST, NR1H4, NR1I3
49serine447.1NR1H2, NR1I2, GAST, INS, KRT19, TERT
50testosterone44 59 11 2410.1KRT19, NR1I2, TERT, INS, NR1H4, NR1H2

GO Terms for genes affiliated with Biliary Tract Disease

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16Gene Ontology
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Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6TERT, NR1H4, NR1H2, NR1I3, NR1I2

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.5NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.3NR1H2, INS
3negative regulation of proteolysisGO:0458619.1INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.0NR1H4, NR1H2, NR1I3, NR1I2
5gene expressionGO:0104679.0NR1H4, NR1H2, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1H4, NR1I3
2retinoid X receptor bindingGO:0469659.7NR1H4, NR1H2
3steroid hormone receptor activityGO:0037079.5NR1I2, NR1H2, NR1H4
4transcription coactivator activityGO:0037139.4NR1H4, NR1I3, NR1I2
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H4, NR1H2, NR1I3, NR1I2
6sequence-specific DNA bindingGO:0435658.9NR1I2, NR1I3, NR1H2, NR1H4
7zinc ion bindingGO:0082708.2SOD1, NR1I2, NR1I3, NR1H2, NR1H4
8protein bindingGO:0055156.2SOD1, GAST, NR1I2, NR1H2, NR1H4, INS

Products for genes affiliated with Biliary Tract Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Biliary Tract Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet