MCID: BLR006
MIFTS: 46

Biliary Tract Disease malady

Gastrointestinal category

Summaries for Biliary Tract Disease

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to hepatitis b and acute pancreatitis. An important gene associated with Biliary Tract Disease is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Drug Induction of Bile Acid Pathway. The compounds pregnanedione and androstanol have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Biliary Tract Disease

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

biliary tract disease 8
biliary tract diseases 61


External Ids:

Disease Ontology8 DOID:9741
ICD9CM27 576.9
NCIt40 C2899
MeSH35 D001660
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b30.1TERT
2acute pancreatitis30.1SPINK1, SOD1
3vascular disease30.1NR1H2, NR1H4, SOD1, INS
4sickle cell disease10.4
5obstructive jaundice10.3
6sickle cell anemia10.2
7bacteriuria10.1
8cystadenoma10.1
9cystic fibrosis10.1
10beta thalassemia10.1
11portal hypertension10.1
12eosinophilic gastroenteritis10.1
13acquired immunodeficiency syndrome10.1
14hepatitis d10.1
15sclerosing cholangitis10.1
16n syndrome10.1
17cholelithiasis10.1
18hepatitis a10.1
19thalassemia10.1
20nodular regenerative hyperplasia10.1
21pancreatitis, chronic10.1
22astrocytoma10.0NR1I3
23rickets10.0NR1H2
24colon adenocarcinoma10.0NR1I2
25biliary atresia10.0NR1H4
26lung cancer10.0KRT19
27addison's disease10.0NR1H2
28maturity-onset diabetes of the young10.0INS
29esophagitis10.0GAST
30gastrinoma10.0GAST
31blindness10.0INS
32gastric ulcer10.0GAST
33coronary heart disease10.0INS
34stomach cancer10.0GAST
35glucagonoma10.0GAST
36skin cancer10.0NR1H2
37glioblastoma multiforme10.0TERT
38cerebrotendinous xanthomatosis10.0NR1I2, NR1H4
39idiopathic pulmonary fibrosis10.0TERT
40osteoarthritis10.0NR1H4, NR1H2
41hepatoblastoma10.0NR1H2, NR1H4
42asthma10.0NR1H2, NR1I2
43meningioma10.0TERT
44pancreas disease10.0GAST, SPINK1
45multinodular goiter10.0KRT19
46hyperparathyroidism10.0NR1I3, GAST
47primary sclerosing cholangitis10.0KRT19, NR1I2
48gastrointestinal system disease10.0GAST, NR1I2
49pancreatic islet cell tumors10.0GAST
50primary hyperparathyroidism10.0NR1I3, GAST

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Clinical Features for Biliary Tract Disease

Drugs & Therapeutics for Biliary Tract Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Biliary Tract Disease

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Search CenterWatch for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

Anatomical Context for Biliary Tract Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Biliary Tract Disease:

33
Liver, Lung, Heart, Testis, T cells, B cells

Animal Models for Biliary Tract Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Biliary Tract Disease

Sources:
51PubMed
See all sources

Articles related to Biliary Tract Disease:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Patterns of initial disease recurrence after resection of biliary tract cancer. (22777276)
2012
2
Imaging of biliary tract disease. (21940525)
2011
3
Management of biliary tract disease during pregnancy: a decision analysis. (17713817)
2008
4
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. (17063088)
2006
5
Imaging the spectrum of biliary tract disease. (12479714)
2002
6
Endoscopic therapy for biliary tract disease before orthotopic liver transplantation. (11175974)
2001
7
Management of biliary tract disease in heart and lung transplant patients. (11015098)
2000
8
Endoscopic and surgical integration in the approach to biliary tract disease. (10192603)
1999
9
A prospective comparison of magnetic resonance cholangiopancreatography with endoscopic retrograde cholangiopancreatography in the evaluation of patients with suspected biliary tract disease. (10484218)
1999
10
The use of magnetic resonance cholangiopancreatography in the management of biliary tract disease in pregnancy. (15512428)
1999
11
Surgical considerations in the contemporary management of biliary tract disease in the postpartum period. (9776152)
1998
12
Surgical biliary bypass for benign and malignant extrahepatic biliary tract disease. (9112898)
1997
13
Endoscopic retrograde cholangiopancreatography (ERCP) in biliary tract disease of infants less than one year old. (9149341)
1997
14
Risk of recurrent biliary tract disease after cholecystectomy in patients with duodenal diverticula. (8857907)
1996
15
Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsymptomatic biliary tract disease. (8322833)
1993
16
Experimental reovirus type 3-induced murine biliary tract disease. (1640330)
1992
17
Calculus biliary tract disease in beta-thalassemia trait. (2638339)
1989
18
Significance of asymptomatic biliary tract disease in heart transplant recipients. (2795282)
1989
19
Medical and surgical aspects of biliary tract disease. (3433101)
1987
20
Radiologic approaches to the treatment of benign and malignant biliary tract disease. (2448881)
1987
21
Dextropropoxyphene induced hepatotoxicity mimicking biliary tract disease. (3957112)
1986
22
Choledochoduodenostomy for calculous biliary tract disease. (3977591)
1985
23
Relationship between perivaterian diverticulum and biliary tract disease. (3936742)
1985
24
Sphincteroplasty in the treatment of biliary tract disease. A prospective study of 46 cases. (6200743)
1984
25
Investigation and management of biliary tract disease. (6647217)
1983
26
Intra-operative pathologic diagnosis of biliary tract disease. (6798332)
1982
27
A trial of glucagon in the treatment of painful biliary tract disease. (6751455)
1982
28
Radionuclide hepatobiliary imaging in the detection of traumatic biliary tract disease in children. (7110762)
1982
29
Ultrasonography and computed tomography in the evaluation of biliary tract disease. (7054617)
1982
30
Biliary scintigraphy: comparison with other modern techniques for evaluation of biliary tract disease. (6812035)
1982
31
"The choledocho-pancreatic long common channel disorders" in relation to the etiology of congenital biliary dilatation and other biliary tract disease. (6178349)
1981
32
Choledochoduodenostomy in calculous biliary tract disease. (7296244)
1981
33
Endoscopic diagnosis and treatment of biliary tract disease. (7025295)
1981
34
The incidence and causes of death following surgery for nonmalignant biliary tract disease. (7362293)
1980
35
Evaluation of ultrasound in the diagnosis of acute and chronic biliary tract disease. (637721)
1978
36
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease. (576886)
1977
37
Benign biliary tract disease in the patient over 80. (937854)
1976
38
Detection of biliary tract disease at operation. (4200402)
1973
39
IgM type II dysimmunoglobulinemia associated with chronic biliary tract disease. Report of a case with a brief review of literature. (4668295)
1972
40
Comparative evaluation of preoperative and operative radiology in biliary-tract disease. (5014524)
1972
41
Surgical treatment of biliary tract disease associated with acute pancreatitis. (5456922)
1970
42
Surgical timing in biliary tract disease. (6022302)
1967
43
The confluence stone. A hazardous complication of biliary tract disease. (6021450)
1967
44
Biliary tract disease among the Navajos. (6072604)
1967
45
INTRAVENOUS CHOLANGIOGRAPHY USED IN POSTCHOLECYSTECTOMY BILIARY TRACT DISEASE. (14220649)
1965
46
SURGICAL TREATMENT OF BILIARY TRACT DISEASE. (14142440)
1964
47
Biliary tract disease; a review of 369 consecutive surgical cases. (13356210)
1956
48
Surgical treatment of noncalculous biliary tract disease. (13242402)
1955
49
Function tests in the diagnosis of biliary tract disease using sodium dehydrocholate or secretin. (14840586)
1951
50
Chronic biliary tract disease. (20289549)
1947

Genetic Variations for Biliary Tract Disease

Expression for genes affiliated with Biliary Tract Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

Sources:
50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome
See all sources

Compounds for genes affiliated with Biliary Tract Disease

Sources:
29IUPHAR, 45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pregnanedione2910.2NR1I3, NR1I2
2androstanol4510.2NR1I3, NR1I2
3androstenol4510.0NR1I2, NR1I3
4t 09013176010.0NR1H2, NR1H4
5gw 3965 hydrochloride6010.0NR1H2, NR1H4
6fexaramine60 29 1112.0NR1H2, NR1H4
77alpha-hydroxy-4-cholesten-3-one459.9NR1H2, NR1I2
8citco45 2910.8NR1H2, NR1I2, NR1I3
9dmes459.8NR1H2, NR1I3, NR1I2
10N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE119.8NR1H2, NR1I2
11gw 406445 6010.8NR1H4, NR1H2, NR1I2
12steroidal459.7NR1H4, NR1I3, NR1H2
13pregnane459.7NR1I3, NR1I2
14lg 100268459.7NR1H4, NR1H2
15ursodeoxycholic acid45 11 2411.7NR1H2, NR1H4, NR1I2
16rifampicin45 29 6011.7NR1H2, NR1I3, NR1I2
17omeprazole45 29 50 11 2413.6GAST, NR1I3, NR1I2
18calcium gluconate459.6INS, GAST
19tocopherol459.6NR1I2, NR1H2, SOD1
20taurocholate459.5NR1H2, NR1H4, GAST
21lithocholic acid45 29 2411.5NR1I3, NR1I2, NR1H2, NR1H4
22androstane459.5NR1I2, NR1H2, NR1H4, NR1I3
23chenodeoxycholic acid45 29 11 2412.5NR1H2, NR1H4, NR1I2, NR1I3
24sterol459.4NR1H4, NR1H2, NR1I3, NR1I2
25phenobarbital45 29 1111.4NR1H2, NR1I2, NR1I3
26betacarotene459.4NR1H2, NR1I2, SOD1
27smcc459.4KRT19, NR1H2
28dhea459.2INS, NR1H4, NR1I3, NR1I2
29dexamethasone45 50 29 1112.2NR1I3, NR1I2, NR1H2, INS
30arsenite45 2410.1NR1I2, SOD1, TERT, NR1H2
31paclitaxel45 50 1111.0TERT, NR1I3, KRT19
32acetaminophen45 2 50 11 2413.0GAST, NR1I2, NR1I3
33hydrocortisone45 2 60 1112.0INS, GAST, NR1H2, NR1I2
34thyroxine45 2410.0INS, NR1H2, NR1I2, GAST
35vitamin d458.9NR1H4, NR1H2, NR1I3, NR1I2, GAST
36retinoid458.8NR1I2, NR1H4, NR1H2, KRT19
37steroid458.8NR1H2, NR1I3, NR1H4, KRT19
38glucose458.8NR1I2, KRT19, GAST, NR1H4
39cholesterol45 29 11 2411.7NR1H4, INS, NR1H2, NR1I2, NR1I3
40progesterone45 60 29 11 2412.5KRT19, NR1I3, NR1H4, NR1I2, NR1H2
41calcitriol45 60 11 2411.5TERT, NR1H4, NR1H2, NR1I2, GAST, NR1I3
42cisplatin45 50 60 1111.2KRT19, NR1I2, SOD1, GAST, TERT
43arginine458.2SOD1, NR1I3, NR1H2, TERT, INS, NR1H4
44retinoic acid45 249.1NR1H4, KRT19, NR1H2, TERT, NR1I3, NR1I2
45thymidine45 249.1NR1I2, GAST, TERT, KRT19, NR1H4, NR1I3
46creatinine458.1INS, KRT19, SPINK1, SOD1, GAST
47lipid457.8INS, NR1H4, SOD1, TERT, NR1H2, NR1I3
48tyrosine457.4TERT, NR1I2, KRT19, GAST, NR1H4, NR1I3
49serine457.1NR1H2, NR1I2, GAST, INS, KRT19, TERT
50testosterone45 60 11 2410.1KRT19, NR1I2, TERT, INS, NR1H4, NR1H2

GO Terms for genes affiliated with Biliary Tract Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6TERT, NR1H4, NR1H2, NR1I3, NR1I2

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.5NR1I3, NR1H4, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.3INS, NR1H2
3negative regulation of proteolysisGO:0458619.1INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.0NR1H4, NR1I2, NR1I3, NR1H2
5gene expressionGO:0104679.0NR1I3, NR1H2, NR1H4, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1H4, NR1I3
2retinoid X receptor bindingGO:0469659.7NR1H4, NR1H2
3steroid hormone receptor activityGO:0037079.5NR1I2, NR1H2, NR1H4
4transcription coactivator activityGO:0037139.4NR1H4, NR1I3, NR1I2
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H4, NR1H2, NR1I3, NR1I2
6sequence-specific DNA bindingGO:0435658.9NR1I2, NR1I3, NR1H2, NR1H4
7zinc ion bindingGO:0082708.2SOD1, NR1I2, NR1I3, NR1H2, NR1H4
8protein bindingGO:0055156.2SOD1, GAST, NR1I2, NR1H2, NR1H4, INS

Products for genes affiliated with Biliary Tract Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Biliary Tract Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet