MCID: BLR006
MIFTS: 51

Biliary Tract Disease malady

Gastrointestinal diseases category
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Summaries for Biliary Tract Disease

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33MalaCards
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MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to pancreatitis and duodenitis. An important gene associated with Biliary Tract Disease is NR1I3 (nuclear receptor subfamily 1, group I, member 3), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Nuclear receptors in lipid metabolism and toxicity. The compounds androstanol and pregnanedione have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are no phenotypic analysis and integument.

Aliases & Classifications for Biliary Tract Disease

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

biliary tract disease 8
biliary tract diseases 62


External Ids:

Disease Ontology8 DOID:9741
MeSH35 D001660
ICD9CM27 576.9
NCIt40 C2899
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

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17GeneCards, 18GeneDecks
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Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.8SPINK1, INS, SOD1
2duodenitis30.6GAST
3obesity30.1NR1H2, NR1H4, NR1I3, INS
4acute pancreatitis30.0SOD1, SPINK1
5cholecystitis10.4
6hepatitis10.3
7sickle cell anemia10.2
8obstructive jaundice10.2
9cerebrotendinous xanthomatosis10.1NR1H4, NR1I2
10pancreas disease10.1GAST, SPINK1
11primary hyperparathyroidism10.1NR1I3, GAST
12gastrointestinal system disease10.1NR1I2, GAST
13cystic fibrosis10.1
14cystadenoma10.1
15bacteriuria10.1
16portal hypertension10.1
17eosinophilic gastroenteritis10.1
18acquired immunodeficiency syndrome10.1
19cholelithiasis10.1
20beta thalassemia10.1
21sclerosing cholangitis10.1
22down syndrome10.1
23cholangitis10.1
24duodenal obstruction10.1
25gastroenteritis10.1
26hypertension10.1
27pancreatic cystadenoma10.1
28thalassemia10.1
29sickle cell disease10.1
30nodular regenerative hyperplasia10.1
31non-a-e hepatitis10.1
32hyperparathyroidism10.1GAST, NR1I3
33hyperinsulinemic hypoglycemia10.1GAST, INS
34primary sclerosing cholangitis10.0NR1I2, KRT19
35gastroparesis10.0INS, GAST
36duodenal ulcer10.0GAST, INS
37autonomic neuropathy10.0INS, GAST
38hypercalcemia10.0SPINK1, NR1I3, GAST
39familial combined hyperlipidemia10.0NR1H2, INS
40gastritis10.0GAST, TERT
41recurrent acute pancreatitis10.0SPINK1, SOD1
42neuroendocrine carcinoma10.0GAST, KRT19
43lipodystrophy10.0NR1H2, INS
44hepatoblastoma10.0NR1H2, NR1H4
45postcholecystectomy syndrome10.0GAST, SOD1
46adenoameloblastoma10.0KRT19, TERT
47infertility10.0NR1H2, INS, SPINK1
48atrophic gastritis10.0SOD1, GAST
49pancreatic cancer10.0GAST, KRT19, SPINK1
50intrahepatic cholestasis10.0NR1H2, NR1H4, NR1I3, NR1I2

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Symptoms for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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33MalaCards
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MalaCards organs/tissues related to Biliary Tract Disease:

33
Liver, Testes, Heart, Lung

Animal Models for Biliary Tract Disease or affiliated genes

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37MGI
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Publications for Biliary Tract Disease

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52PubMed
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Articles related to Biliary Tract Disease:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
2
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. (22828544)
2012
3
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. (17063088)
2006
4
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
5
The role of microorganisms in biliary tract disease. (11900683)
2002
6
Endoscopic management of biliary tract disease. (17023988)
1999
7
The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. (10222553)
1999
8
Surgical considerations in the contemporary management of biliary tract disease in the postpartum period. (9776152)
1998
9
Helicobacters and biliary tract disease. (9547101)
1998
10
Surgical biliary bypass for benign and malignant extrahepatic biliary tract disease. (9112898)
1997
11
Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsymptomatic biliary tract disease. (8322833)
1993
12
Biliary tract disease in the aged. (1855163)
1991
13
Biliary tract disease in AIDS: AIDS vs. nonAIDS. (2401465)
1990
14
Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. (2649414)
1989
15
Biliary tract disease due to Fasciola hepatica: report of a case. (2775403)
1989
16
Therapeutic options for biliary tract disease in advanced cirrhosis. (3344896)
1988
17
Choledochoduodenostomy for calculous biliary tract disease. (3977591)
1985
18
Investigation and management of biliary tract disease. (6647217)
1983
19
Intra-operative pathologic diagnosis of biliary tract disease. (6798332)
1982
20
Spontaneous cholecystocutaneous fistula: a complication of neglected biliary tract disease. (7119329)
1982
21
Early re-operation after surgery for calculous biliary tract disease. (7171431)
1982
22
Biliary tract disease--clinical approach to a particular subset of patients. (6212574)
1982
23
Clinical conferences at the Johns Hopkins Hospital. Klatskin tumor: radiologic features of biliary tract disease. (6273640)
1981
24
Symposium on biliary tract disease. (7280935)
1981
25
Choledochoduodenostomy in the treatment of benign biliary tract disease. (7457731)
1981
26
Endoscopic papillotomy in the geriatric patient with complicated biliary-tract disease. (7462544)
1981
27
Acute biliary tract disease associated with echovirus 11 infection. (7256335)
1981
28
Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease. (7437863)
1980
29
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease. (576886)
1977
30
Benign biliary tract disease in the patient over 80. (937854)
1976
31
Calculous biliary tract disease. (1139966)
1975
32
The role of obstruction and infection in biliary tract disease. (4568835)
1973
33
Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease. (4585506)
1973
34
Endoscopic pancreatocholangiography in the diagnosis of biliary tract disease. (4591875)
1973
35
Surgical aspects of biliary tract disease. (4941159)
1971
36
Calculous biliary tract disease. (5763325)
1969
37
Indications for operation in biliary tract disease among the elderly. (5797468)
1969
38
Diagnostic methods in biliary tract disease. (5944618)
1966
39
Duodenal diverticula. Relationship to biliary tract disease. (5936548)
1966
40
INTRAVENOUS CHOLANGIOGRAPHY USED IN POSTCHOLECYSTECTOMY BILIARY TRACT DISEASE. (14220649)
1965
41
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
42
SECRETIN TESTS OF PANCREATIC AND BILIARY TRACT DISEASE. (14156065)
1964
43
SURGICAL TREATMENT OF BILIARY TRACT DISEASE. (14142440)
1964
44
Limitations of diagnostic studies in demonstrating biliary tract disease producing colic. (14025525)
1963
45
Progress in gallbladder and biliary tract disease. (13626913)
1959
46
Experience with unusual biliary tract disease. (13631460)
1959
47
Chronic biliary tract disease. (20289549)
1947
48
A new roentgen sign in extrahepatic biliary tract disease. (20997773)
1946
49
BILIARY tract disease. (21016532)
1946
50
Some Factors Involved in the Care of the Patient Seriously Ill with Biliary Tract Disease. (18745883)
1941

Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 55Reactome
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Pathways related to Biliary Tract Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NR1I2, NR1I3
29.5NR1H4, NR1I3, NR1I2
39.5NR1I2, NR1I3, NR1H4
4
Show member pathways
FOXA transcription factor networks38
9.3SOD1, INS
5
Show member pathways
Vitamin B12 Metabolism38
9.3SOD1, INS
69.2NR1I3, NR1I2, INS
79.1INS, NR1I2, NR1H4
8
Show member pathways
Nuclear Receptors38
9.0NR1H2, NR1H4, NR1I3, NR1I2

Compounds for genes affiliated with Biliary Tract Disease

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1androstanol4510.2NR1I3, NR1I2
2pregnanedione2910.1NR1I2, NR1I3
3gw 3965 hydrochloride6110.0NR1H4, NR1H2
4fexaramine61 29 1112.0NR1H4, NR1H2
5t 09013176110.0NR1H4, NR1H2
6dmes459.8NR1I2, NR1I3, NR1H2
7citco45 2910.8NR1I3, NR1H2, NR1I2
8androstenol459.8NR1I2, NR1I3
9pregnane459.8NR1I3, NR1I2
10steroidal459.8NR1H2, NR1I3, NR1H4
11gw 406461 4510.8NR1I2, NR1H4, NR1H2
127alpha-hydroxy-4-cholesten-3-one459.8NR1I2, NR1H2
13ursodeoxycholic acid45 24 1111.7NR1H4, NR1H2, NR1I2
14rifampicin45 29 6111.6NR1I3, NR1H2, NR1I2
15tocopherol459.5SOD1, NR1I2, NR1H2
16lithocholic acid45 29 2411.5NR1I2, NR1H4, NR1H2, NR1I3
17androstane459.5NR1H2, NR1H4, NR1I3, NR1I2
18chenodeoxycholic acid45 29 24 1112.5NR1H2, NR1H4, NR1I2, NR1I3
19sterol459.4NR1I2, NR1H2, NR1I3, NR1H4
20betacarotene459.3NR1I2, SOD1, NR1H2
21omeprazole45 51 29 24 1113.3NR1I2, NR1I3, GAST
22dhea459.3NR1I2, INS, NR1H4, NR1I3
23calcium gluconate459.3GAST, INS
24smcc459.2KRT19, NR1H2
25taurocholate459.2GAST, NR1H2, NR1H4
26retinoid459.1NR1I2, NR1H4, NR1H2, KRT19
27arsenite45 2410.1NR1H2, SOD1, NR1I2, TERT
28paclitaxel45 51 1111.0TERT, NR1I2, NR1I3, KRT19
29acetaminophen45 3 51 24 1112.9NR1I3, GAST, NR1I2
30progesterone45 29 61 24 1112.9KRT19, NR1I3, NR1I2, NR1H4, NR1H2
31steroid458.8KRT19, NR1I2, NR1I3, NR1H4, NR1H2
32cholesterol45 29 24 1111.7NR1H4, NR1I3, NR1I2, INS, NR1H2
33hydrocortisone45 3 61 1111.7GAST, NR1H2, NR1I2, INS
34vitamin d458.6NR1H4, NR1I3, NR1H2, GAST, NR1I2
35thyroxine45 249.6GAST, NR1H2, NR1I2, INS
36retinoic acid45 249.5NR1I3, NR1I2, TERT, NR1H4, NR1H2, KRT19
37arginine458.2NR1I3, TERT, INS, NR1H4, NR1H2, SOD1
38calcitriol45 61 24 1111.2TERT, NR1I2, NR1I3, NR1H4, NR1H2, GAST
39cisplatin45 51 61 1111.2TERT, NR1I2, KRT19, GAST, SOD1
40thymidine45 249.1NR1I2, GAST, KRT19, NR1H4, NR1I3, TERT
41creatinine458.0SOD1, GAST, KRT19, SPINK1, INS
42dexamethasone45 51 29 1111.0INS, GAST, NR1I2, NR1I3, NR1H4, NR1H2
43glutamate457.9INS, SOD1, NR1I3, NR1H2, GAST
44alanine457.9SOD1, INS, NR1I3, GAST, NR1H2
45lipid457.9TERT, NR1I3, NR1H4, NR1H2, NR1I2, SOD1
46glucose457.8KRT19, NR1H2, NR1H4, NR1I2, INS, GAST
47tyrosine457.4KRT19, NR1H4, NR1I3, GAST, NR1I2, INS
48serine457.1TERT, SPINK1, NR1I3, INS, NR1I2, NR1H2
49testosterone45 61 24 1110.1NR1I3, KRT19, NR1I2, NR1H2, NR1H4, TERT
50estrogen457.1NR1I2, INS, NR1H2, KRT19, NR1I3, GAST

GO Terms for genes affiliated with Biliary Tract Disease

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16Gene Ontology
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Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6NR1H2, NR1H4, NR1I3, NR1I2, TERT

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.6NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.4NR1H2, INS
3negative regulation of proteolysisGO:0458619.3INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.1NR1I2, NR1I3, NR1H4, NR1H2
5gene expressionGO:0104678.7NR1H2, NR1H4, NR1I3, NR1I2
6signal transductionGO:0071658.6GAST, NR1H4, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1I3, NR1H4
2steroid hormone receptor activityGO:0037079.5NR1H2, NR1I2, NR1H4
3transcription coactivator activityGO:0037139.5NR1H4, NR1I3, NR1I2
4retinoid X receptor bindingGO:0469659.4NR1H2, NR1H4
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H4, NR1I2, NR1I3, NR1H2
6sequence-specific DNA bindingGO:0435659.0NR1I3, NR1H4, NR1I2, NR1H2
7zinc ion bindingGO:0082708.4SOD1, NR1I2, NR1I3, NR1H4, NR1H2
8protein bindingGO:0055156.2GAST, NR1H2, NR1H4, NR1I2, SOD1, INS

Products for genes affiliated with Biliary Tract Disease

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Sources for Biliary Tract Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet