MCID: BLR006
MIFTS: 51

Biliary Tract Disease malady

Gastrointestinal diseases category

Summaries for Biliary Tract Disease

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34MalaCards
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MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to pancreatitis and duodenitis. An important gene associated with Biliary Tract Disease is NR1I3 (nuclear receptor subfamily 1, group I, member 3), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Nuclear receptors in lipid metabolism and toxicity. The compounds androstanol and pregnanedione have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are no phenotypic analysis and integument.

Aliases & Classifications for Biliary Tract Disease

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

biliary tract disease 9
biliary tract diseases 63


External Ids:

Disease Ontology9 DOID:9741
MeSH36 D001660
ICD9CM28 576.9
NCIt41 C2899
ICD1026 K83.8

Related Diseases for Biliary Tract Disease

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18GeneCards, 19GeneDecks
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Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.8SPINK1, INS, SOD1
2duodenitis30.6GAST
3obesity30.1NR1H2, NR1H4, NR1I3, INS
4acute pancreatitis30.0SOD1, SPINK1
5cholecystitis10.4
6hepatitis10.3
7sickle cell anemia10.2
8obstructive jaundice10.2
9cerebrotendinous xanthomatosis10.1NR1H4, NR1I2
10pancreas disease10.1GAST, SPINK1
11primary hyperparathyroidism10.1NR1I3, GAST
12gastrointestinal system disease10.1NR1I2, GAST
13cystic fibrosis10.1
14cystadenoma10.1
15bacteriuria10.1
16portal hypertension10.1
17eosinophilic gastroenteritis10.1
18acquired immunodeficiency syndrome10.1
19cholelithiasis10.1
20beta thalassemia10.1
21sclerosing cholangitis10.1
22down syndrome10.1
23cholangitis10.1
24duodenal obstruction10.1
25gastroenteritis10.1
26hypertension10.1
27pancreatic cystadenoma10.1
28thalassemia10.1
29sickle cell disease10.1
30nodular regenerative hyperplasia10.1
31non-a-e hepatitis10.1
32hyperparathyroidism10.1GAST, NR1I3
33hyperinsulinemic hypoglycemia10.1GAST, INS
34primary sclerosing cholangitis10.0NR1I2, KRT19
35gastroparesis10.0INS, GAST
36duodenal ulcer10.0GAST, INS
37autonomic neuropathy10.0INS, GAST
38hypercalcemia10.0SPINK1, NR1I3, GAST
39familial combined hyperlipidemia10.0NR1H2, INS
40gastritis10.0GAST, TERT
41recurrent acute pancreatitis10.0SPINK1, SOD1
42neuroendocrine carcinoma10.0GAST, KRT19
43lipodystrophy10.0NR1H2, INS
44hepatoblastoma10.0NR1H2, NR1H4
45postcholecystectomy syndrome10.0GAST, SOD1
46adenoameloblastoma10.0KRT19, TERT
47infertility10.0NR1H2, INS, SPINK1
48atrophic gastritis10.0SOD1, GAST
49pancreatic cancer10.0GAST, KRT19, SPINK1
50intrahepatic cholestasis10.0NR1H2, NR1H4, NR1I3, NR1I2

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Symptoms for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Biliary Tract Disease

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Search CenterWatch for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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34MalaCards
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MalaCards organs/tissues related to Biliary Tract Disease:

34
Liver, Testes, Heart, Lung

Animal Models for Biliary Tract Disease or affiliated genes

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38MGI
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Publications for Biliary Tract Disease

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53PubMed
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Articles related to Biliary Tract Disease:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
2
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. (22828544)
2012
3
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. (17063088)
2006
4
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
5
The role of microorganisms in biliary tract disease. (11900683)
2002
6
Endoscopic management of biliary tract disease. (17023988)
1999
7
The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. (10222553)
1999
8
Surgical considerations in the contemporary management of biliary tract disease in the postpartum period. (9776152)
1998
9
Helicobacters and biliary tract disease. (9547101)
1998
10
Surgical biliary bypass for benign and malignant extrahepatic biliary tract disease. (9112898)
1997
11
Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsymptomatic biliary tract disease. (8322833)
1993
12
Biliary tract disease in the aged. (1855163)
1991
13
Biliary tract disease in AIDS: AIDS vs. nonAIDS. (2401465)
1990
14
Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. (2649414)
1989
15
Biliary tract disease due to Fasciola hepatica: report of a case. (2775403)
1989
16
Therapeutic options for biliary tract disease in advanced cirrhosis. (3344896)
1988
17
Choledochoduodenostomy for calculous biliary tract disease. (3977591)
1985
18
Investigation and management of biliary tract disease. (6647217)
1983
19
Intra-operative pathologic diagnosis of biliary tract disease. (6798332)
1982
20
Spontaneous cholecystocutaneous fistula: a complication of neglected biliary tract disease. (7119329)
1982
21
Early re-operation after surgery for calculous biliary tract disease. (7171431)
1982
22
Biliary tract disease--clinical approach to a particular subset of patients. (6212574)
1982
23
Clinical conferences at the Johns Hopkins Hospital. Klatskin tumor: radiologic features of biliary tract disease. (6273640)
1981
24
Symposium on biliary tract disease. (7280935)
1981
25
Choledochoduodenostomy in the treatment of benign biliary tract disease. (7457731)
1981
26
Endoscopic papillotomy in the geriatric patient with complicated biliary-tract disease. (7462544)
1981
27
Acute biliary tract disease associated with echovirus 11 infection. (7256335)
1981
28
Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease. (7437863)
1980
29
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease. (576886)
1977
30
Benign biliary tract disease in the patient over 80. (937854)
1976
31
Calculous biliary tract disease. (1139966)
1975
32
The role of obstruction and infection in biliary tract disease. (4568835)
1973
33
Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease. (4585506)
1973
34
Endoscopic pancreatocholangiography in the diagnosis of biliary tract disease. (4591875)
1973
35
Surgical aspects of biliary tract disease. (4941159)
1971
36
Calculous biliary tract disease. (5763325)
1969
37
Indications for operation in biliary tract disease among the elderly. (5797468)
1969
38
Diagnostic methods in biliary tract disease. (5944618)
1966
39
Duodenal diverticula. Relationship to biliary tract disease. (5936548)
1966
40
INTRAVENOUS CHOLANGIOGRAPHY USED IN POSTCHOLECYSTECTOMY BILIARY TRACT DISEASE. (14220649)
1965
41
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
42
SECRETIN TESTS OF PANCREATIC AND BILIARY TRACT DISEASE. (14156065)
1964
43
SURGICAL TREATMENT OF BILIARY TRACT DISEASE. (14142440)
1964
44
Limitations of diagnostic studies in demonstrating biliary tract disease producing colic. (14025525)
1963
45
Progress in gallbladder and biliary tract disease. (13626913)
1959
46
Experience with unusual biliary tract disease. (13631460)
1959
47
Chronic biliary tract disease. (20289549)
1947
48
A new roentgen sign in extrahepatic biliary tract disease. (20997773)
1946
49
BILIARY tract disease. (21016532)
1946
50
Some Factors Involved in the Care of the Patient Seriously Ill with Biliary Tract Disease. (18745883)
1941

Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome
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Pathways related to Biliary Tract Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NR1I2, NR1I3
29.5NR1H4, NR1I3, NR1I2
39.5NR1I2, NR1I3, NR1H4
4
Show member pathways
FOXA transcription factor networks39
9.3SOD1, INS
5
Show member pathways
Vitamin B12 Metabolism39
9.3SOD1, INS
69.2NR1I3, NR1I2, INS
79.1INS, NR1I2, NR1H4
8
Show member pathways
Nuclear Receptors39
9.0NR1H2, NR1H4, NR1I3, NR1I2

Compounds for genes affiliated with Biliary Tract Disease

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1androstanol4610.2NR1I3, NR1I2
2pregnanedione3010.1NR1I2, NR1I3
3gw 3965 hydrochloride6210.0NR1H4, NR1H2
4fexaramine62 30 1212.0NR1H4, NR1H2
5t 09013176210.0NR1H4, NR1H2
6dmes469.8NR1I2, NR1I3, NR1H2
7citco46 3010.8NR1I3, NR1H2, NR1I2
8androstenol469.8NR1I2, NR1I3
9pregnane469.8NR1I3, NR1I2
10steroidal469.8NR1H2, NR1I3, NR1H4
11gw 406462 4610.8NR1I2, NR1H4, NR1H2
127alpha-hydroxy-4-cholesten-3-one469.8NR1I2, NR1H2
13ursodeoxycholic acid46 25 1211.7NR1H4, NR1H2, NR1I2
14rifampicin46 30 6211.6NR1I3, NR1H2, NR1I2
15tocopherol469.5SOD1, NR1I2, NR1H2
16lithocholic acid46 30 2511.5NR1I2, NR1H4, NR1H2, NR1I3
17androstane469.5NR1H2, NR1H4, NR1I3, NR1I2
18chenodeoxycholic acid46 30 25 1212.5NR1H2, NR1H4, NR1I2, NR1I3
19sterol469.4NR1I2, NR1H2, NR1I3, NR1H4
20betacarotene469.3NR1I2, SOD1, NR1H2
21omeprazole46 52 30 25 1213.3NR1I2, NR1I3, GAST
22dhea469.3NR1I2, INS, NR1H4, NR1I3
23calcium gluconate469.3GAST, INS
24smcc469.2KRT19, NR1H2
25taurocholate469.2GAST, NR1H2, NR1H4
26retinoid469.1NR1I2, NR1H4, NR1H2, KRT19
27arsenite46 2510.1NR1H2, SOD1, NR1I2, TERT
28paclitaxel46 52 1211.0TERT, NR1I2, NR1I3, KRT19
29acetaminophen46 3 52 25 1212.9NR1I3, GAST, NR1I2
30progesterone46 30 62 25 1212.9KRT19, NR1I3, NR1I2, NR1H4, NR1H2
31steroid468.8KRT19, NR1I2, NR1I3, NR1H4, NR1H2
32cholesterol46 30 25 1211.7NR1H4, NR1I3, NR1I2, INS, NR1H2
33hydrocortisone46 3 62 1211.7GAST, NR1H2, NR1I2, INS
34vitamin d468.6NR1H4, NR1I3, NR1H2, GAST, NR1I2
35thyroxine46 259.6GAST, NR1H2, NR1I2, INS
36retinoic acid46 259.5NR1I3, NR1I2, TERT, NR1H4, NR1H2, KRT19
37arginine468.2NR1I3, TERT, INS, NR1H4, NR1H2, SOD1
38calcitriol46 62 25 1211.2TERT, NR1I2, NR1I3, NR1H4, NR1H2, GAST
39cisplatin46 52 62 1211.2TERT, NR1I2, KRT19, GAST, SOD1
40thymidine46 259.1NR1I2, GAST, KRT19, NR1H4, NR1I3, TERT
41creatinine468.0SOD1, GAST, KRT19, SPINK1, INS
42dexamethasone46 52 30 1211.0INS, GAST, NR1I2, NR1I3, NR1H4, NR1H2
43glutamate467.9INS, SOD1, NR1I3, NR1H2, GAST
44alanine467.9SOD1, INS, NR1I3, GAST, NR1H2
45lipid467.9TERT, NR1I3, NR1H4, NR1H2, NR1I2, SOD1
46glucose467.8KRT19, NR1H2, NR1H4, NR1I2, INS, GAST
47tyrosine467.4KRT19, NR1H4, NR1I3, GAST, NR1I2, INS
48serine467.1TERT, SPINK1, NR1I3, INS, NR1I2, NR1H2
49testosterone46 62 25 1210.1NR1I3, KRT19, NR1I2, NR1H2, NR1H4, TERT
50estrogen467.1NR1I2, INS, NR1H2, KRT19, NR1I3, GAST

GO Terms for genes affiliated with Biliary Tract Disease

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17Gene Ontology
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Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6NR1H2, NR1H4, NR1I3, NR1I2, TERT

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.6NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.4NR1H2, INS
3negative regulation of proteolysisGO:0458619.3INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.1NR1I2, NR1I3, NR1H4, NR1H2
5gene expressionGO:0104678.7NR1H2, NR1H4, NR1I3, NR1I2
6signal transductionGO:0071658.6GAST, NR1H4, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1I3, NR1H4
2steroid hormone receptor activityGO:0037079.5NR1H2, NR1I2, NR1H4
3transcription coactivator activityGO:0037139.5NR1H4, NR1I3, NR1I2
4retinoid X receptor bindingGO:0469659.4NR1H2, NR1H4
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H4, NR1I2, NR1I3, NR1H2
6sequence-specific DNA bindingGO:0435659.0NR1I3, NR1H4, NR1I2, NR1H2
7zinc ion bindingGO:0082708.4SOD1, NR1I2, NR1I3, NR1H4, NR1H2
8protein bindingGO:0055156.2GAST, NR1H2, NR1H4, NR1I2, SOD1, INS

Products for genes affiliated with Biliary Tract Disease

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Sources for Biliary Tract Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet