MCID: BLR006
MIFTS: 51

Biliary Tract Disease malady

Gastrointestinal diseases category
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Summaries for Biliary Tract Disease

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MalaCards based summary: Biliary Tract Disease, also known as biliary tract diseases, is related to duodenitis and pancreatitis. An important gene associated with Biliary Tract Disease is NR1I3 (nuclear receptor subfamily 1, group I, member 3), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Nuclear receptors in lipid metabolism and toxicity. The compounds androstanol and pregnanedione have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are no phenotypic analysis and integument.

Aliases & Classifications for Biliary Tract Disease

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Biliary Tract Disease, Aliases & Descriptions:

Name: Biliary Tract Disease 8
 
Biliary Tract Diseases 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:9741
ICD9CM27 576.9
MeSH34 D001660
NCIt39 C2899
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

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Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.1GAST
2pancreatitis30.8SPINK1, SOD1, INS
3acute pancreatitis30.1SPINK1, SOD1
4obesity30.0INS, NR1H4, NR1H2, NR1I3
5cholecystitis10.4
6cerebrotendinous xanthomatosis10.3NR1H4, NR1I2
7hepatitis10.3
8obstructive jaundice10.3
9pancreas disease10.3SPINK1, GAST
10primary hyperparathyroidism10.3GAST, NR1I3
11gastrointestinal system disease10.3NR1I2, GAST
12hyperparathyroidism10.2GAST, NR1I3
13hyperinsulinemic hypoglycemia10.2INS, GAST
14primary sclerosing cholangitis10.2NR1I2, KRT19
15sickle cell anemia10.2
16gastroparesis10.2INS, GAST
17duodenal ulcer10.2GAST, INS
18gastrointestinal carcinoma10.2GAST, KRT19
19hypercalcemia10.2NR1I3, GAST, SPINK1
20autonomic neuropathy10.2INS, GAST
21familial combined hyperlipidemia10.2INS, NR1H2
22gastritis10.2GAST, TERT
23recurrent acute pancreatitis10.2SPINK1, SOD1
24neuroendocrine carcinoma10.2KRT19, GAST
25lipodystrophy10.1NR1H2, INS
26postcholecystectomy syndrome10.1GAST, SOD1
27infertility10.1INS, SPINK1, NR1H2
28ameloblastoma10.1KRT19, TERT
29atrophic gastritis10.1SOD1, GAST
30pancreatic cancer10.1SPINK1, KRT19, GAST
31cystic fibrosis10.1
32hypertension10.1
33thalassemia10.1
34cystadenoma10.1
35sclerosing cholangitis10.1
36down syndrome10.1
37bacteriuria10.1
38acquired immunodeficiency syndrome10.1
39cholelithiasis10.1
40beta thalassemia10.1
41portal hypertension10.1
42eosinophilic gastroenteritis10.1
43cholangitis10.1
44duodenal obstruction10.1
45gastroenteritis10.1
46pancreatic cystadenoma10.1
47sickle cell disease10.1
48nodular regenerative hyperplasia10.1
49non-a-e hepatitis10.1
50intrahepatic cholestasis10.0NR1H2, NR1H4, NR1I3, NR1I2

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Symptoms for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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MalaCards organs/tissues related to Biliary Tract Disease:

32
Liver, Testes, Heart, Lung

Animal Models for Biliary Tract Disease or affiliated genes

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Publications for Biliary Tract Disease

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Articles related to Biliary Tract Disease:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
2
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. (22828544)
2012
3
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. (17063088)
2006
4
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
5
The role of microorganisms in biliary tract disease. (11900683)
2002
6
Endoscopic management of biliary tract disease. (17023988)
1999
7
The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. (10222553)
1999
8
Surgical considerations in the contemporary management of biliary tract disease in the postpartum period. (9776152)
1998
9
Helicobacters and biliary tract disease. (9547101)
1998
10
Surgical biliary bypass for benign and malignant extrahepatic biliary tract disease. (9112898)
1997
11
Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsymptomatic biliary tract disease. (8322833)
1993
12
Biliary tract disease in the aged. (1855163)
1991
13
Biliary tract disease in AIDS: AIDS vs. nonAIDS. (2401465)
1990
14
Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. (2649414)
1989
15
Biliary tract disease due to Fasciola hepatica: report of a case. (2775403)
1989
16
Therapeutic options for biliary tract disease in advanced cirrhosis. (3344896)
1988
17
Investigation and management of biliary tract disease. (6647217)
1983
18
Intra-operative pathologic diagnosis of biliary tract disease. (6798332)
1982
19
Spontaneous cholecystocutaneous fistula: a complication of neglected biliary tract disease. (7119329)
1982
20
Early re-operation after surgery for calculous biliary tract disease. (7171431)
1982
21
Biliary tract disease--clinical approach to a particular subset of patients. (6212574)
1982
22
Clinical conferences at the Johns Hopkins Hospital. Klatskin tumor: radiologic features of biliary tract disease. (6273640)
1981
23
Symposium on biliary tract disease. (7280935)
1981
24
Choledochoduodenostomy in the treatment of benign biliary tract disease. (7457731)
1981
25
Endoscopic papillotomy in the geriatric patient with complicated biliary-tract disease. (7462544)
1981
26
Acute biliary tract disease associated with echovirus 11 infection. (7256335)
1981
27
Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease. (7437863)
1980
28
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease. (576886)
1977
29
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975
30
Calculous biliary tract disease. (1139966)
1975
31
The role of obstruction and infection in biliary tract disease. (4568835)
1973
32
Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease. (4585506)
1973
33
Endoscopic pancreatocholangiography in the diagnosis of biliary tract disease. (4591875)
1973
34
Management of complicated biliary-tract disease in geriatric patients. (5082123)
1972
35
Surgical aspects of biliary tract disease. (4941159)
1971
36
Calculous biliary tract disease. (5763325)
1969
37
Indications for operation in biliary tract disease among the elderly. (5797468)
1969
38
Diagnostic methods in biliary tract disease. (5944618)
1966
39
Duodenal diverticula. Relationship to biliary tract disease. (5936548)
1966
40
INTRAVENOUS CHOLANGIOGRAPHY USED IN POSTCHOLECYSTECTOMY BILIARY TRACT DISEASE. (14220649)
1965
41
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
42
SECRETIN TESTS OF PANCREATIC AND BILIARY TRACT DISEASE. (14156065)
1964
43
SURGICAL TREATMENT OF BILIARY TRACT DISEASE. (14142440)
1964
44
Limitations of diagnostic studies in demonstrating biliary tract disease producing colic. (14025525)
1963
45
Progress in gallbladder and biliary tract disease. (13626913)
1959
46
Experience with unusual biliary tract disease. (13631460)
1959
47
Chronic biliary tract disease. (20289549)
1947
48
A new roentgen sign in extrahepatic biliary tract disease. (20997773)
1946
49
BILIARY tract disease. (21016532)
1946
50
Some Factors Involved in the Care of the Patient Seriously Ill with Biliary Tract Disease. (18745883)
1941

Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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Pathways related to Biliary Tract Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NR1I2, NR1I3
29.5NR1H4, NR1I3, NR1I2
39.5NR1I2, NR1I3, NR1H4
4
Show member pathways
FOXA transcription factor networks37
9.3SOD1, INS
5
Show member pathways
Vitamin B12 Metabolism37
9.3SOD1, INS
69.2NR1I3, NR1I2, INS
79.1INS, NR1I2, NR1H4
8
Show member pathways
Nuclear Receptors37
9.0NR1H2, NR1H4, NR1I3, NR1I2

Compounds for genes affiliated with Biliary Tract Disease

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Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1androstanol4410.2NR1I3, NR1I2
2pregnanedione2810.1NR1I2, NR1I3
3gw 3965 hydrochloride6110.0NR1H4, NR1H2
4fexaramine61 28 1112.0NR1H4, NR1H2
5t 09013176110.0NR1H4, NR1H2
6dmes449.8NR1I2, NR1I3, NR1H2
7citco44 2810.8NR1I3, NR1H2, NR1I2
8androstenol449.8NR1I2, NR1I3
9pregnane449.8NR1I3, NR1I2
10steroidal449.8NR1H2, NR1I3, NR1H4
11gw 406461 4410.8NR1I2, NR1H4, NR1H2
127alpha-hydroxy-4-cholesten-3-one449.8NR1I2, NR1H2
13ursodeoxycholic acid44 24 1111.7NR1H4, NR1H2, NR1I2
14rifampicin44 28 6111.6NR1I3, NR1H2, NR1I2
15tocopherol449.5SOD1, NR1I2, NR1H2
16lithocholic acid44 28 2411.5NR1I2, NR1H4, NR1H2, NR1I3
17androstane449.5NR1H2, NR1H4, NR1I3, NR1I2
18chenodeoxycholic acid44 28 24 1112.5NR1H2, NR1H4, NR1I2, NR1I3
19sterol449.4NR1I2, NR1H2, NR1I3, NR1H4
20betacarotene449.3NR1I2, SOD1, NR1H2
21omeprazole44 50 28 24 1113.3NR1I2, NR1I3, GAST
22dhea449.3NR1I2, INS, NR1H4, NR1I3
23calcium gluconate449.3GAST, INS
24smcc449.2KRT19, NR1H2
25taurocholate449.2GAST, NR1H2, NR1H4
26retinoid449.1NR1I2, NR1H4, NR1H2, KRT19
27arsenite44 2410.1NR1H2, SOD1, NR1I2, TERT
28paclitaxel44 50 1111.0TERT, NR1I2, NR1I3, KRT19
29acetaminophen44 2 50 24 1112.9NR1I3, GAST, NR1I2
30progesterone44 28 61 24 1112.9KRT19, NR1I3, NR1I2, NR1H4, NR1H2
31steroid448.8KRT19, NR1I2, NR1I3, NR1H4, NR1H2
32cholesterol44 28 24 1111.7NR1H4, NR1I3, NR1I2, INS, NR1H2
33hydrocortisone44 2 61 1111.7GAST, NR1H2, NR1I2, INS
34vitamin d448.6NR1H4, NR1I3, NR1H2, GAST, NR1I2
35thyroxine44 249.6GAST, NR1H2, NR1I2, INS
36retinoic acid44 249.5NR1I3, NR1I2, TERT, NR1H4, NR1H2, KRT19
37arginine448.2NR1I3, TERT, INS, NR1H4, NR1H2, SOD1
38calcitriol44 61 24 1111.2TERT, NR1I2, NR1I3, NR1H4, NR1H2, GAST
39cisplatin44 50 61 1111.2TERT, NR1I2, KRT19, GAST, SOD1
40thymidine44 249.1NR1I2, GAST, KRT19, NR1H4, NR1I3, TERT
41creatinine448.0SOD1, GAST, KRT19, SPINK1, INS
42dexamethasone44 50 28 1111.0INS, GAST, NR1I2, NR1I3, NR1H4, NR1H2
43glutamate447.9INS, SOD1, NR1I3, NR1H2, GAST
44alanine447.9SOD1, INS, NR1I3, GAST, NR1H2
45lipid447.9TERT, NR1I3, NR1H4, NR1H2, NR1I2, SOD1
46glucose447.8KRT19, NR1H2, NR1H4, NR1I2, INS, GAST
47tyrosine447.4KRT19, NR1H4, NR1I3, GAST, NR1I2, INS
48serine447.1TERT, SPINK1, NR1I3, INS, NR1I2, NR1H2
49testosterone44 61 24 1110.1NR1I3, KRT19, NR1I2, NR1H2, NR1H4, TERT
50estrogen447.1NR1I2, INS, NR1H2, KRT19, NR1I3, GAST

GO Terms for genes affiliated with Biliary Tract Disease

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Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6NR1H2, NR1H4, NR1I3, NR1I2, TERT

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.6NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.4NR1H2, INS
3negative regulation of proteolysisGO:0458619.3INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.1NR1I2, NR1I3, NR1H4, NR1H2
5gene expressionGO:0104678.7NR1H2, NR1H4, NR1I3, NR1I2
6signal transductionGO:0071658.6GAST, NR1H4, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1I3, NR1H4
2steroid hormone receptor activityGO:0037079.5NR1H2, NR1H4, NR1I2
3transcription coactivator activityGO:0037139.5NR1H4, NR1I3, NR1I2
4retinoid X receptor bindingGO:0469659.4NR1H2, NR1H4
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H2, NR1H4, NR1I3, NR1I2
6sequence-specific DNA bindingGO:0435659.0NR1H2, NR1H4, NR1I3, NR1I2
7zinc ion bindingGO:0082708.4SOD1, NR1I2, NR1I3, NR1H4, NR1H2
8protein bindingGO:0055156.2TERT, SPINK1, INS, SOD1, NR1I2, NR1H4

Products for genes affiliated with Biliary Tract Disease

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Sources for Biliary Tract Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet