MCID: BLR006
MIFTS: 49

Biliary Tract Disease malady

Gastrointestinal diseases category

Summaries for Biliary Tract Disease

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to pancreatitis and acute pancreatitis. An important gene associated with Biliary Tract Disease is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Drug Induction of Bile Acid Pathway. The compounds pregnanedione and androstanol have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Biliary Tract Disease

About this section
Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

biliary tract disease 8
biliary tract diseases 60


External Ids:

Disease Ontology8 DOID:9741
ICD9CM27 576.9
NCIt39 C2899
MeSH34 D001660
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Clinical Features for Biliary Tract Disease

About this section

Drugs & Therapeutics for Biliary Tract Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Biliary Tract Disease

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Search CenterWatch for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

About this section

Anatomical Context for Biliary Tract Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Biliary Tract Disease:

32
Liver, Testes, Heart, Lung, Testis, T cells

Animal Models for Biliary Tract Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Biliary Tract Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7KRT19
2MP:00053898.2NR1I2, NR1I3, NR1H2, KRT19, TERT
3MP:00053707.9SOD1, NR1I2, NR1I3, NR1H2, NR1H4, INS
4MP:00053817.5SPINK1, TERT, KRT19, INS, GAST
5MP:00053877.2SOD1, GAST, NR1H2, NR1H4, INS, TERT
6MP:00053797.0SOD1, GAST, NR1H2, INS, KRT19, TERT
7MP:00053766.8SOD1, GAST, NR1I2, NR1I3, NR1H2, NR1H4
8MP:00053846.6SOD1, NR1I2, NR1I3, NR1H2, NR1H4, INS
9MP:00107686.0SPINK1, SOD1, GAST, NR1I2, NR1I3, NR1H2

Publications for Biliary Tract Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Biliary Tract Disease:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Hyaline vascular Castleman's disease involving the biliary tract. (23951980)
2013
2
Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. (23479678)
2013
3
Management of biliary tract disease during pregnancy. (20193902)
2010
4
Double-balloon enteroscopy application in biliary tract disease-its therapeutic and diagnostic functions. (18561917)
2008
5
Biliary tract disease as a risk factor for Plesiomonas shigelloides bacteraemia: a nine-year experience in a Hong Kong hospital and review of the literature. (15782626)
2005
6
Biliary tract disease: a rare manifestation of eosinophilic gastroenteritis. (12757181)
2003
7
Prenatal diagnosis of liver and biliary tract disease. (15001123)
2003
8
Endoscopic management of biliary tract disease. (17031203)
2001
9
Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. (11347977)
2001
10
Recommendations for management of liver and biliary tract disease in cystic fibrosis. Cystic Fibrosis Foundation Hepatobiliary Disease Consensus Group. (9934970)
1999
11
Helicobacters and biliary tract disease. (9547101)
1998
12
Nonoperative treatment of biliary tract disease. (9820346)
1998
13
Biliary tract disease in children. (8596687)
1996
14
Biliary tract disease in AIDS: AIDS vs. nonAIDS. (2401465)
1990
15
Efficacy of plain abdominal radiography in patients with biliary tract disease. (2373835)
1990
16
Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. (2649414)
1989
17
Acquired immunodeficiency syndrome and biliary tract disease. (3826968)
1987
18
Biliary tract disease. Is there a difference in men? (3592067)
1987
19
Choledochoduodenostomy. A safe and efficacious alternative in the treatment of biliary tract disease. (3800159)
1987
20
Endoscopic treatment of biliary tract disease. (3811495)
1986
21
Presence/absence of homogeneous Telepaque in the bowel: an aid in diagnosing biliary tract disease. (6438555)
1984
22
Biliary tract disease--clinical approach to a particular subset of patients. (6212574)
1982
23
Frequency and indication for choledochoduodenostomy in benign biliary tract disease. Reassessment of therapeutic application. (6756182)
1982
24
Endoscopic sphincterotomy in biliary tract disease. (7096046)
1982
25
Symposium on biliary tract disease. (7280935)
1981
26
Intraoperative choledochoscopy: an efficacious adjunct to common duct exploration in calculous biliary tract disease. (7212455)
1981
27
Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease. (7437863)
1980
28
Use of biliary drainage in diagnosis of biliary tract disease. (900106)
1977
29
Choledochoduodenostomy in the treatment of benign biliary tract disease. (901170)
1977
30
Comparative biliary concentrations of cephazolin and cephalothin in patients with biliary tract disease. (1265475)
1976
31
Evaluation of biliary tract disease by ultrasonic B-mode scanning. (990698)
1976
32
Duodenal obstruction related to benign biliary tract disease. (1148961)
1975
33
Bacteria and biliary tract disease. (4613198)
1974
34
Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease. (4585506)
1973
35
Cephalexin levels in human bile in presence of biliary tract disease. (5069220)
1972
36
Surgical aspects of biliary tract disease. (4941159)
1971
37
Marked elevation of serum transaminase activities in extrahepatic biliary tract disease. (5567735)
1971
38
Biliary tract disease since antiquity. (4932002)
1971
39
Ampicillin levels in human bile in the presence of biliary tract disease. (5790272)
1969
40
A new physical sign in biliary-tract disease. (5726037)
1968
41
Surgical management of biliary tract disease. (5955743)
1966
42
Disturbances of liver function in biliary tract disease. (5953950)
1966
43
BILIARY TRACT DISEASE. (14129903)
1964
44
Biliary tract disease following Billroth II subtotal gastrectomy. (13616852)
1959
45
Surgical problems in biliary tract disease; drainage of the common duct. (13545216)
1958
46
Acute and chronic cholecystitis: a classification of biliary tract disease. (13561005)
1958
47
Recent additions to radiographic techniques in biliary tract disease. (13397695)
1956
48
The roentgen diagnosis of gallbladder and biliary tract disease without cholecystography. (13197625)
1954
49
Biliary tract disease; diagnosis and treatment. (13193210)
1954
50
BILIARY tract disease. (21016532)
1946

Genetic Variations for Biliary Tract Disease

About this section

Expression for genes affiliated with Biliary Tract Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

About this section
Sources:
49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
See all sources

Compounds for genes affiliated with Biliary Tract Disease

About this section
Sources:
28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pregnanedione2810.2NR1I3, NR1I2
2androstanol4410.2NR1I3, NR1I2
3androstenol4410.0NR1I2, NR1I3
4t 09013175910.0NR1H2, NR1H4
5gw 3965 hydrochloride5910.0NR1H2, NR1H4
6fexaramine59 28 1112.0NR1H2, NR1H4
77alpha-hydroxy-4-cholesten-3-one449.9NR1H2, NR1I2
8citco44 2810.8NR1H2, NR1I2, NR1I3
9dmes449.8NR1H2, NR1I3, NR1I2
10N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE119.8NR1H2, NR1I2
11gw 406444 5910.8NR1H4, NR1H2, NR1I2
12steroidal449.7NR1H4, NR1I3, NR1H2
13pregnane449.7NR1I3, NR1I2
14lg 100268449.7NR1H4, NR1H2
15ursodeoxycholic acid44 11 2411.7NR1H2, NR1H4, NR1I2
16rifampicin44 28 5911.7NR1H2, NR1I3, NR1I2
17omeprazole44 28 49 11 2413.6GAST, NR1I3, NR1I2
18calcium gluconate449.6INS, GAST
19tocopherol449.6NR1I2, NR1H2, SOD1
20taurocholate449.5NR1H2, NR1H4, GAST
21lithocholic acid44 28 2411.5NR1I3, NR1I2, NR1H2, NR1H4
22androstane449.5NR1I2, NR1H2, NR1H4, NR1I3
23chenodeoxycholic acid44 28 11 2412.5NR1H2, NR1H4, NR1I2, NR1I3
24sterol449.4NR1H4, NR1H2, NR1I3, NR1I2
25phenobarbital44 28 1111.4NR1H2, NR1I2, NR1I3
26betacarotene449.4NR1H2, NR1I2, SOD1
27smcc449.4KRT19, NR1H2
28dhea449.2INS, NR1H4, NR1I3, NR1I2
29dexamethasone44 49 28 1112.2NR1I3, NR1I2, NR1H2, INS
30arsenite44 2410.1NR1I2, SOD1, TERT, NR1H2
31paclitaxel44 49 1111.0TERT, NR1I3, KRT19
32acetaminophen44 2 49 11 2413.0GAST, NR1I2, NR1I3
33hydrocortisone44 2 59 1112.0INS, GAST, NR1H2, NR1I2
34thyroxine44 2410.0INS, NR1H2, NR1I2, GAST
35vitamin d448.9NR1H4, NR1H2, NR1I3, NR1I2, GAST
36retinoid448.8NR1I2, NR1H4, NR1H2, KRT19
37steroid448.8NR1H2, NR1I3, NR1H4, KRT19
38glucose448.8NR1I2, KRT19, GAST, NR1H4
39cholesterol44 28 11 2411.7NR1H4, INS, NR1H2, NR1I2, NR1I3
40progesterone44 59 28 11 2412.5KRT19, NR1I3, NR1H4, NR1I2, NR1H2
41calcitriol44 59 11 2411.5TERT, NR1H4, NR1H2, NR1I2, GAST, NR1I3
42cisplatin44 49 59 1111.2KRT19, NR1I2, SOD1, GAST, TERT
43arginine448.2SOD1, NR1I3, NR1H2, TERT, INS, NR1H4
44retinoic acid44 249.1NR1H4, KRT19, NR1H2, TERT, NR1I3, NR1I2
45thymidine44 249.1NR1I2, GAST, TERT, KRT19, NR1H4, NR1I3
46creatinine448.1INS, KRT19, SPINK1, SOD1, GAST
47lipid447.8INS, NR1H4, SOD1, TERT, NR1H2, NR1I3
48tyrosine447.4TERT, NR1I2, KRT19, GAST, NR1H4, NR1I3
49serine447.1NR1H2, NR1I2, GAST, INS, KRT19, TERT
50testosterone44 59 11 2410.1KRT19, NR1I2, TERT, INS, NR1H4, NR1H2

GO Terms for genes affiliated with Biliary Tract Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6TERT, NR1H4, NR1H2, NR1I3, NR1I2

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.5NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.3NR1H2, INS
3negative regulation of proteolysisGO:0458619.1INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.0NR1H4, NR1H2, NR1I3, NR1I2
5gene expressionGO:0104679.0NR1H4, NR1H2, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1H4, NR1I3
2retinoid X receptor bindingGO:0469659.7NR1H4, NR1H2
3steroid hormone receptor activityGO:0037079.5NR1I2, NR1H2, NR1H4
4transcription coactivator activityGO:0037139.4NR1H4, NR1I3, NR1I2
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H4, NR1H2, NR1I3, NR1I2
6sequence-specific DNA bindingGO:0435658.9NR1I2, NR1I3, NR1H2, NR1H4
7zinc ion bindingGO:0082708.2SOD1, NR1I2, NR1I3, NR1H2, NR1H4
8protein bindingGO:0055156.2SOD1, GAST, NR1I2, NR1H2, NR1H4, INS

Products for genes affiliated with Biliary Tract Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Biliary Tract Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet