MCID: BLR006
MIFTS: 43

Biliary Tract Disease malady

Gastrointestinal diseases category

Aliases & Classifications for Biliary Tract Disease

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Biliary Tract Disease, Aliases & Descriptions:

Name: Biliary Tract Disease 9
 
Biliary Tract Diseases 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:9741
MeSH33 D001660
ICD9CM27 576.9
NCIt38 C2899
ICD1025 K83.8

Summaries for Biliary Tract Disease

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MalaCards based summary: Biliary Tract Disease, also known as biliary tract diseases, is related to duodenitis and pancreatitis. An important gene associated with Biliary Tract Disease is NR1I3 (nuclear receptor subfamily 1, group I, member 3), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Nuclear receptors in lipid metabolism and toxicity. The compounds androstanol and pregnanedione have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are no phenotypic analysis and integument.

Related Diseases for Biliary Tract Disease

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Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.1GAST
2pancreatitis30.8SPINK1, INS, SOD1
3obesity30.0NR1H2, NR1H4, NR1I3, INS
4acute pancreatitis29.8SOD1, SPINK1
5cholecystitis10.4
6cerebrotendinous xanthomatosis10.3NR1H4, NR1I2
7hepatitis10.3
8obstructive jaundice10.3
9pancreas disease10.3GAST, SPINK1
10primary hyperparathyroidism10.3NR1I3, GAST
11gastrointestinal system disease10.2NR1I2, GAST
12hyperparathyroidism10.2GAST, NR1I3
13sickle cell anemia10.2
14hyperinsulinemic hypoglycemia, familial, 210.2GAST, INS
15hyperinsulinemic hypoglycemia10.2GAST, INS
16cholangitis, primary sclerosing10.2NR1I2, KRT19
17gastroparesis10.2INS, GAST
18duodenal ulcer10.2GAST, INS
19gastrointestinal carcinoma10.2GAST, KRT19
20autonomic neuropathy10.2INS, GAST
21hypercalcemia10.2SPINK1, NR1I3, GAST
22hyperlipidemia, familial combined10.2NR1H2, INS
23gastritis10.2GAST, TERT
24recurrent acute pancreatitis10.2SPINK1, SOD1
25neuroendocrine tumor10.1GAST, KRT19
26lipodystrophy10.1NR1H2, INS
27hepatoblastoma10.1NR1H2, NR1H4
28postcholecystectomy syndrome10.1GAST, SOD1
29lipid metabolism disorder10.1INS, NR1H4, NR1H2
30infertility10.1NR1H2, INS, SPINK1
31ameloblastoma10.1KRT19, TERT
32atrophic gastritis10.1SOD1, GAST
33pancreatic cancer10.1GAST, KRT19, SPINK1
34cystic fibrosis10.1
35thalassemia10.1
36cystadenoma10.1
37bacteriuria10.1
38portal hypertension10.1
39eosinophilic gastroenteritis10.1
40acquired immunodeficiency syndrome10.1
41cholelithiasis10.1
42sclerosing cholangitis10.1
43down syndrome10.1
44cholangitis10.1
45duodenal obstruction10.1
46gastroenteritis10.1
47pancreatic cystadenoma10.1
48sickle cell disease10.1
49nodular regenerative hyperplasia10.1
50non-a-e hepatitis10.1

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Symptoms for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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MalaCards organs/tissues related to Biliary Tract Disease:

31
Liver, Testes, Heart, Lung

Animal Models for Biliary Tract Disease or affiliated genes

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Publications for Biliary Tract Disease

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Articles related to Biliary Tract Disease:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. (23695896)
2013
2
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. (22828544)
2012
3
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. (17063088)
2006
4
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
5
The role of microorganisms in biliary tract disease. (11900683)
2002
6
Endoscopic management of biliary tract disease. (17023988)
1999
7
The pathogenesis of biliary stone formation and its prevention in biliary tract diseases]. (10222553)
1999
8
Surgical considerations in the contemporary management of biliary tract disease in the postpartum period. (9776152)
1998
9
Helicobacters and biliary tract disease. (9547101)
1998
10
Surgical biliary bypass for benign and malignant extrahepatic biliary tract disease. (9112898)
1997
11
Abdominal ultrasound scan in Down syndrome patients: high frequency of nonsymptomatic biliary tract disease. (8322833)
1993
12
Biliary tract disease in the aged. (1855163)
1991
13
Biliary tract disease in AIDS: AIDS vs. nonAIDS. (2401465)
1990
14
Prevalence of biliary tract disease in India: a sonographic study in adult population in Kashmir. (2649414)
1989
15
Biliary tract disease due to Fasciola hepatica: report of a case. (2775403)
1989
16
Therapeutic options for biliary tract disease in advanced cirrhosis. (3344896)
1988
17
Choledochoduodenostomy for calculous biliary tract disease. (3977591)
1985
18
Investigation and management of biliary tract disease. (6647217)
1983
19
Intra-operative pathologic diagnosis of biliary tract disease. (6798332)
1982
20
Spontaneous cholecystocutaneous fistula: a complication of neglected biliary tract disease. (7119329)
1982
21
Early re-operation after surgery for calculous biliary tract disease. (7171431)
1982
22
Biliary tract disease--clinical approach to a particular subset of patients. (6212574)
1982
23
Clinical conferences at the Johns Hopkins Hospital. Klatskin tumor: radiologic features of biliary tract disease. (6273640)
1981
24
Symposium on biliary tract disease. (7280935)
1981
25
Choledochoduodenostomy in the treatment of benign biliary tract disease. (7457731)
1981
26
Endoscopic papillotomy in the geriatric patient with complicated biliary-tract disease. (7462544)
1981
27
Acute biliary tract disease associated with echovirus 11 infection. (7256335)
1981
28
Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease. (7437863)
1980
29
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease. (576886)
1977
30
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975
31
Calculous biliary tract disease. (1139966)
1975
32
The role of obstruction and infection in biliary tract disease. (4568835)
1973
33
Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease. (4585506)
1973
34
Endoscopic pancreatocholangiography in the diagnosis of biliary tract disease. (4591875)
1973
35
Management of complicated biliary-tract disease in geriatric patients. (5082123)
1972
36
Surgical aspects of biliary tract disease. (4941159)
1971
37
Calculous biliary tract disease. (5763325)
1969
38
Indications for operation in biliary tract disease among the elderly. (5797468)
1969
39
Diagnostic methods in biliary tract disease. (5944618)
1966
40
Duodenal diverticula. Relationship to biliary tract disease. (5936548)
1966
41
INTRAVENOUS CHOLANGIOGRAPHY USED IN POSTCHOLECYSTECTOMY BILIARY TRACT DISEASE. (14220649)
1965
42
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
43
SECRETIN TESTS OF PANCREATIC AND BILIARY TRACT DISEASE. (14156065)
1964
44
SURGICAL TREATMENT OF BILIARY TRACT DISEASE. (14142440)
1964
45
Limitations of diagnostic studies in demonstrating biliary tract disease producing colic. (14025525)
1963
46
Progress in gallbladder and biliary tract disease. (13626913)
1959
47
Experience with unusual biliary tract disease. (13631460)
1959
48
A new roentgen sign in extrahepatic biliary tract disease. (20997773)
1946
49
BILIARY tract disease. (21016532)
1946
50
Some Factors Involved in the Care of the Patient Seriously Ill with Biliary Tract Disease. (18745883)
1941

Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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Pathways related to Biliary Tract Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NR1I2, NR1I3
29.5NR1H4, NR1I3, NR1I2
39.5NR1I2, NR1I3, NR1H4
4
Show member pathways
FOXA transcription factor networks36
9.3SOD1, INS
5
Show member pathways
Vitamin B12 Metabolism36
9.3SOD1, INS
6
Show member pathways
Nuclear Receptors36
9.0NR1H2, NR1H4, NR1I3, NR1I2

Compounds for genes affiliated with Biliary Tract Disease

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Compounds related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1androstanol4310.2NR1I3, NR1I2
2pregnanedione2810.1NR1I3, NR1I2
3fexaramine59 28 1212.0NR1H4, NR1H2
4gw 3965 hydrochloride5910.0NR1H4, NR1H2
5t 09013175910.0NR1H4, NR1H2
6dmes439.8NR1I2, NR1I3, NR1H2
7citco43 2810.8NR1I2, NR1I3, NR1H2
8androstenol439.8NR1I3, NR1I2
9pregnane439.8NR1I3, NR1I2
10steroidal439.8NR1H2, NR1H4, NR1I3
11gw 406459 4310.8NR1H2, NR1H4, NR1I2
127alpha-hydroxy-4-cholesten-3-one439.8NR1H2, NR1I2
13ursodeoxycholic acid43 24 1211.7NR1I2, NR1H4, NR1H2
14rifampicin43 28 5911.6NR1I2, NR1I3, NR1H2
15tocopherol439.5NR1H2, NR1I2, SOD1
16lithocholic acid43 28 2411.5NR1I2, NR1I3, NR1H4, NR1H2
17androstane439.5NR1I2, NR1I3, NR1H4, NR1H2
18chenodeoxycholic acid43 28 24 1212.5NR1I2, NR1I3, NR1H4, NR1H2
19sterol439.4NR1I2, NR1I3, NR1H4, NR1H2
20betacarotene439.3NR1H2, NR1I2, SOD1
21omeprazole43 49 28 24 1213.3NR1I2, NR1I3, GAST
22dhea439.3INS, NR1I2, NR1I3, NR1H4
23calcium gluconate439.3GAST, INS
24smcc439.2KRT19, NR1H2
25taurocholate439.2GAST, NR1H2, NR1H4
26retinoid439.1NR1I2, NR1H4, NR1H2, KRT19
27arsenite43 2410.1TERT, SOD1, NR1I2, NR1H2
28paclitaxel43 49 1211.0TERT, NR1I2, NR1I3, KRT19
29acetaminophen43 2 49 24 1212.9NR1I2, NR1I3, GAST
30progesterone43 28 59 24 1212.9NR1I2, NR1I3, NR1H4, NR1H2, KRT19
31steroid438.8NR1I2, NR1I3, NR1H4, NR1H2, KRT19
32cholesterol43 28 24 1211.7NR1H2, NR1H4, NR1I3, NR1I2, INS
33hydrocortisone43 2 59 1211.7INS, NR1I2, NR1H2, GAST
34vitamin d438.6NR1I2, NR1I3, NR1H4, NR1H2, GAST
35thyroxine43 249.6GAST, NR1H2, NR1I2, INS
36retinoic acid43 249.5TERT, NR1I2, NR1I3, NR1H4, NR1H2, KRT19
37arginine438.2TERT, INS, SOD1, NR1I3, NR1H4, NR1H2
38calcitriol43 59 24 1211.2TERT, NR1I2, NR1I3, NR1H4, NR1H2, GAST
39cisplatin43 49 59 1211.2TERT, SOD1, NR1I2, KRT19, GAST
40thymidine43 249.1TERT, NR1I2, NR1I3, NR1H4, KRT19, GAST
41creatinine438.0SPINK1, INS, SOD1, KRT19, GAST
42dexamethasone43 49 28 1211.0INS, NR1I2, NR1I3, NR1H4, NR1H2, GAST
43glutamate437.9INS, SOD1, NR1I3, NR1H2, GAST
44alanine437.9INS, SOD1, NR1I3, NR1H2, GAST
45lipid437.9TERT, INS, SOD1, NR1I2, NR1I3, NR1H4
46glucose437.8INS, NR1I2, NR1H4, NR1H2, KRT19, GAST
47tyrosine437.4TERT, INS, NR1I2, NR1I3, NR1H4, KRT19
48serine437.1TERT, SPINK1, INS, NR1I2, NR1I3, NR1H2
49testosterone43 59 24 1210.1GAST, TERT, INS, NR1I2, NR1I3, NR1H4
50estrogen437.1TERT, INS, NR1I2, NR1I3, NR1H4, NR1H2

GO Terms for genes affiliated with Biliary Tract Disease

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Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.6NR1H2, NR1H4, NR1I3, NR1I2, TERT

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:00305229.6NR1H4, NR1I3, NR1I2
2positive regulation of cellular protein metabolic processGO:00322709.4NR1H2, INS
3negative regulation of proteolysisGO:00458619.3INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:00063679.1NR1I2, NR1I3, NR1H4, NR1H2
5gene expressionGO:00104678.7NR1H2, NR1H4, NR1I3, NR1I2
6signal transductionGO:00071658.6GAST, NR1H4, NR1I3, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:00048879.9NR1I3, NR1H4
2steroid hormone receptor activityGO:00037079.5NR1H2, NR1H4, NR1I2
3transcription coactivator activityGO:00037139.5NR1H4, NR1I3, NR1I2
4retinoid X receptor bindingGO:00469659.4NR1H2, NR1H4
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.2NR1H2, NR1H4, NR1I3, NR1I2
6sequence-specific DNA bindingGO:00435659.0NR1H2, NR1H4, NR1I3, NR1I2
7zinc ion bindingGO:00082708.4SOD1, NR1I2, NR1I3, NR1H4, NR1H2
8protein bindingGO:00055156.2TERT, SPINK1, INS, SOD1, NR1I2, NR1H4

Products for genes affiliated with Biliary Tract Disease

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Sources for Biliary Tract Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet