MCID: BLR006
MIFTS: 49

Biliary Tract Disease malady

Gastrointestinal diseases category

Summaries for Biliary Tract Disease

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32MalaCards
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MalaCards: Biliary Tract Disease, also known as biliary tract diseases, is related to pancreatitis and acute pancreatitis. An important gene associated with Biliary Tract Disease is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Carbamazepine Pathway, Pharmacokinetics and Drug Induction of Bile Acid Pathway. The compounds pregnanedione and androstanol have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Biliary Tract Disease

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

biliary tract disease 8
biliary tract diseases 60


External Ids:

Disease Ontology8 DOID:9741
ICD9CM27 576.9
NCIt39 C2899
MeSH34 D001660
ICD1025 K83.8

Related Diseases for Biliary Tract Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to biliary tract disease

Clinical Features for Biliary Tract Disease

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Drugs & Therapeutics for Biliary Tract Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Biliary Tract Disease

Drug clinical trials:

Search ClinicalTrials for Biliary Tract Disease

Search NIH Clinical Center for Biliary Tract Disease

Search CenterWatch for Biliary Tract Disease

Genetic Tests for Biliary Tract Disease

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Anatomical Context for Biliary Tract Disease

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32MalaCards
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MalaCards organs/tissues related to Biliary Tract Disease:

32
Liver, Testes, Heart, Lung, Testis, T cells

Animal Models for Biliary Tract Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Biliary Tract Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7KRT19
2MP:00053898.2TERT, KRT19, NR1H2, NR1I2, NR1I3
3MP:00053707.9SOD1, INS, NR1H4, NR1H2, NR1I3, NR1I2
4MP:00053817.5TERT, KRT19, INS, GAST, SPINK1
5MP:00053877.2NR1H2, NR1H4, INS, TERT, GAST, SPINK1
6MP:00053797.0TERT, KRT19, INS, NR1H2, SOD1, SPINK1
7MP:00053766.8SPINK1, TERT, INS, NR1H4, NR1H2, NR1I3
8MP:00053846.6NR1I2, TERT, KRT19, INS, NR1H4, NR1H2
9MP:00107686.0GAST, SOD1, NR1I2, NR1I3, NR1H2, NR1H4

Publications for Biliary Tract Disease

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50PubMed
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Articles related to Biliary Tract Disease:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
High rates of recurrent biliary tract obstruction in children with sickle cell disease. (23255346)
2013
2
A stunning year for advances in biliary tract disease. (21423005)
2011
3
Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathological analysis of Japanese cases of this uncommon disease. (15770404)
2005
4
Complete resection of choledochal cyst with Roux-en-Y derivation vs. cyst-enterostomy as standard treatment of cystic disease of the biliary tract in the adult patient. (15782983)
2005
5
Medical versus surgical management of biliary tract disease in pregnancy. (15619495)
2004
6
Gallbladder and biliary tract disease in the intensive care unit. (12610852)
2003
7
The role of microorganisms in biliary tract disease. (11900683)
2002
8
Biliary tract disease and acute non-A-E hepatitis in Hong Kong: prospective study. (11514745)
2001
9
Experience with percutaneous transhepatic cholangioscopy (PTCS) in the management of biliary tract disease. (10594265)
1999
10
AIDS-associated biliary tract disease. (9510272)
1998
11
Oxidative stress in the liver and biliary tract diseases. (9867111)
1998
12
The impact of laparoscopic cholecystectomy on the management and outcome of biliary tract disease in North Carolina: a statewide, population-based, time-series analysis. (8673305)
1996
13
Parasitic causes of pancreatic and biliary tract disease: a growing concern in a highly mobile population. (20058432)
1994
14
The role of endoscopic ultrasonography in biliary tract disease: obstructive jaundice. (7712994)
1994
15
Evolving management of biliary tract disease. (8351591)
1993
16
Human immunodeficiency virus-associated biliary tract disease. (1636123)
1992
17
Primary choledochoduodenostomy for benign obstructive biliary tract disease. (2398250)
1990
18
Biliary tract disease due to Fasciola hepatica: report of a case. (2775403)
1989
19
Aerobic and anaerobic microbiology of biliary tract disease. (2584384)
1989
20
Therapeutic options for biliary tract disease in advanced cirrhosis. (3344896)
1988
21
Pharmacokinetics of ceftazidime in patients with biliary tract disease. (3539624)
1986
22
Marked elevation of serum transaminase activity associated with extrahepatic biliary tract disease. (4086745)
1985
23
Biliary tract disease in Thailand. (6318376)
1984
24
Endoscopic management of biliary tract disease. (6729738)
1984
25
Biliary tract disease and related surgical disorders during pregnancy. (6661837)
1983
26
Influence of age on the clinical presentation of acute biliary tract disease. (6841945)
1983
27
Spontaneous cholecystocutaneous fistula: a complication of neglected biliary tract disease. (7119329)
1982
28
Diagnosis and treatment of obstructive biliary tract disease. (18749133)
1982
29
Cholescintigraphy and sonography in the diagnosis of biliary tract disease: a retrospective study. (6953249)
1982
30
Utility and accuracy of ultrasonically measured gallbladder wall as a diagnostic criteria in biliary tract disease. (7261832)
1981
31
The role of computed tomography and ultrasound imaging in biliary tract disease. (7025293)
1981
32
Cholelithiasis and biliary tract disease in sickle-cell disease in Nigerians. (482184)
1979
33
Critical sequelae in biliary tract disease. (788579)
1976
34
Route of infection in extrahepatic biliary tract disease. I: Experimental evidence against an entero-hepatico-biliary cycle of bacteria. (818701)
1976
35
Obstructive jaundice in patients with pancreatitis without associated biliary tract disease. (1211986)
1975
36
Excretion of clindamycin in the bile of patients with biliary tract disease. (4747573)
1973
37
Biliary tract disease in Navajo Indians. (5694377)
1968
38
Duodenal diverticula. Relationship to biliary tract disease. (5936548)
1966
39
Pain in biliary tract disease. (5908657)
1966
40
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
41
NURSING CARE AND THE PATIENT WITH BILIARY TRACT DISEASE. (14140024)
1964
42
Surgical management of biliary tract disease complicated by acute renal failure. (13861403)
1961
43
Bacteriological investigation of the biliary system and liver in biliary tract disease correlated to clinical data and microstructure of the gallbladder and liver. (13660715)
1959
44
The serum trihydroxy-dihydroxy bile acid ratio in liver and biliary tract disease. (13587658)
1958
45
Diagnostic use of cholangiography in biliary tract disease. (13291170)
1956
46
The diagnosis and management of biliary-tract disease. (13235999)
1955
47
Surgical treatment of biliary tract disease; a review of 100 cases treated at the 98th General Hospital. (13001420)
1952
48
The use of the secretin test in the diagnosis of biliary tract disease; a report of 327 case studies. (14813411)
1951
49
Biliary tract disease in the aged. (14868209)
1951
50
Some Factors Involved in the Care of the Patient Seriously Ill with Biliary Tract Disease. (18745883)
1941

Genetic Variations for Biliary Tract Disease

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Expression for genes affiliated with Biliary Tract Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for genes affiliated with Biliary Tract Disease

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Biliary Tract Disease

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Sources:
28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1pregnanedione2810.2NR1I3, NR1I2
2androstanol4410.2NR1I3, NR1I2
3androstenol4410.0NR1I2, NR1I3
4t 09013175910.0NR1H2, NR1H4
5gw 3965 hydrochloride5910.0NR1H2, NR1H4
6fexaramine59 28 1112.0NR1H2, NR1H4
77alpha-hydroxy-4-cholesten-3-one449.9NR1H2, NR1I2
8citco44 2810.8NR1H2, NR1I2, NR1I3
9dmes449.8NR1H2, NR1I3, NR1I2
10N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE119.8NR1H2, NR1I2
11gw 406444 5910.8NR1H4, NR1H2, NR1I2
12steroidal449.7NR1H4, NR1I3, NR1H2
13pregnane449.7NR1I3, NR1I2
14lg 100268449.7NR1H4, NR1H2
15ursodeoxycholic acid44 11 2411.7NR1H2, NR1H4, NR1I2
16rifampicin44 28 5911.7NR1H2, NR1I3, NR1I2
17omeprazole44 28 49 11 2413.6GAST, NR1I3, NR1I2
18calcium gluconate449.6INS, GAST
19tocopherol449.6NR1I2, NR1H2, SOD1
20taurocholate449.5NR1H2, NR1H4, GAST
21lithocholic acid44 28 2411.5NR1I3, NR1I2, NR1H2, NR1H4
22androstane449.5NR1I2, NR1H2, NR1H4, NR1I3
23chenodeoxycholic acid44 28 11 2412.5NR1H2, NR1H4, NR1I2, NR1I3
24sterol449.4NR1H4, NR1H2, NR1I3, NR1I2
25phenobarbital44 28 1111.4NR1H2, NR1I2, NR1I3
26betacarotene449.4NR1H2, NR1I2, SOD1
27smcc449.4KRT19, NR1H2
28dhea449.2INS, NR1H4, NR1I3, NR1I2
29dexamethasone44 49 28 1112.2NR1I3, NR1I2, NR1H2, INS
30arsenite44 2410.1NR1I2, SOD1, TERT, NR1H2
31paclitaxel44 49 1111.0TERT, NR1I3, KRT19
32acetaminophen44 2 49 11 2413.0GAST, NR1I2, NR1I3
33hydrocortisone44 2 59 1112.0INS, GAST, NR1H2, NR1I2
34thyroxine44 2410.0INS, NR1H2, NR1I2, GAST
35vitamin d448.9NR1H4, NR1H2, NR1I3, NR1I2, GAST
36retinoid448.8NR1I2, NR1H4, NR1H2, KRT19
37steroid448.8NR1H2, NR1I3, NR1H4, KRT19
38glucose448.8NR1I2, KRT19, GAST, NR1H4
39cholesterol44 28 11 2411.7NR1H4, INS, NR1H2, NR1I2, NR1I3
40progesterone44 59 28 11 2412.5KRT19, NR1I3, NR1H4, NR1I2, NR1H2
41calcitriol44 59 11 2411.5TERT, NR1H4, NR1H2, NR1I2, GAST, NR1I3
42cisplatin44 49 59 1111.2KRT19, NR1I2, SOD1, GAST, TERT
43arginine448.2SOD1, NR1I3, NR1H2, TERT, INS, NR1H4
44retinoic acid44 249.1NR1H4, KRT19, NR1H2, TERT, NR1I3, NR1I2
45thymidine44 249.1NR1I2, GAST, TERT, KRT19, NR1H4, NR1I3
46creatinine448.1INS, KRT19, SPINK1, SOD1, GAST
47lipid447.8INS, NR1H4, SOD1, TERT, NR1H2, NR1I3
48tyrosine447.4TERT, NR1I2, KRT19, GAST, NR1H4, NR1I3
49serine447.1NR1H2, NR1I2, GAST, INS, KRT19, TERT
50testosterone44 59 11 2410.1KRT19, NR1I2, TERT, INS, NR1H4, NR1H2

GO Terms for genes affiliated with Biliary Tract Disease

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16Gene Ontology
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Cellular components related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.6TERT, NR1H4, NR1H2, NR1I3, NR1I2

Biological processes related to Biliary Tract Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:0305229.5NR1I3, NR1H4, NR1I2
2positive regulation of cellular protein metabolic processGO:0322709.3INS, NR1H2
3negative regulation of proteolysisGO:0458619.1INS, NR1H2
4transcription initiation from RNA polymerase II promoterGO:0063679.0NR1H4, NR1I2, NR1I3, NR1H2
5gene expressionGO:0104679.0NR1I3, NR1H2, NR1H4, NR1I2

Molecular functions related to Biliary Tract Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.9NR1H4, NR1I3
2retinoid X receptor bindingGO:0469659.7NR1H4, NR1H2
3steroid hormone receptor activityGO:0037079.5NR1H4, NR1I2, NR1H2
4transcription coactivator activityGO:0037139.4NR1I3, NR1I2, NR1H4
5ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.2NR1H2, NR1I2, NR1I3, NR1H4
6sequence-specific DNA bindingGO:0435658.9NR1H4, NR1I2, NR1I3, NR1H2
7zinc ion bindingGO:0082708.2NR1I3, SOD1, NR1I2, NR1H2, NR1H4
8protein bindingGO:0055156.2NR1H4, NR1H2, NR1I2, SOD1, GAST, INS

Products for genes affiliated with Biliary Tract Disease

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Biliary Tract Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet