MCID: BLR006
MIFTS: 55

Biliary Tract Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Biliary Tract Disease

MalaCards integrated aliases for Biliary Tract Disease:

Name: Biliary Tract Disease 12 14
Biliary Tract Diseases 41 69
Biliary Tract Abnormality 28

Classifications:



External Ids:

Disease Ontology 12 DOID:9741
ICD10 32 K83.9 K83.8
ICD9CM 34 576.9
MeSH 41 D001660
UMLS 69 C0005424

Summaries for Biliary Tract Disease

MalaCards based summary : Biliary Tract Disease, also known as biliary tract diseases, is related to cholecystitis and obstructive jaundice, and has symptoms including digestive system symptom An important gene associated with Biliary Tract Disease is NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Dopamine and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Biliary Tract Disease

Diseases related to Biliary Tract Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 30.3 ABCB4 ALB CCK
2 obstructive jaundice 30.1 ALB GGT1 SLC25A13
3 sclerosing cholangitis 30.1 ABCB11 ABCB4 ALB NR1I2
4 cholangitis 29.9 ABCB11 ABCB4 ALB GGT1
5 cholangitis, primary sclerosing 29.9 ABCB4 GGT1 NR1I2
6 cholelithiasis 29.8 ABCB4 ALB CCK CYP7A1 NR1H4
7 atp8b1 deficiency 10.5 ABCB11 ATP8B1 NR1H4
8 cholestasis, benign recurrent intrahepatic, 1 10.4 ABCB11 ATP8B1
9 cholestasis, progressive familial intrahepatic, 2 10.4 ABCB11 ABCB4 ATP8B1
10 cholestasis, progressive familial intrahepatic, 3 10.4 ABCB11 ABCB4 ATP8B1
11 xanthomatosis 10.4 CYP7A1 NR1H4 NR1I2
12 cerebrotendinous xanthomatosis 10.4 CYP7A1 NR1H4 NR1I2
13 dubin-johnson syndrome 10.3 ABCC2 ABCC3 ABCC4
14 biliary atresia 10.3 ALB NR1H4 SLC10A1
15 cyclosporiasis 10.3 GGT1 GGT2
16 paralytic ileus 10.3 ALB CCK
17 hyperbilirubinemia, rotor type 10.3 ABCC2 ALB
18 algoneurodystrophy 10.3 GGT1 GGT2
19 autoimmune disease of urogenital tract 10.3 ABCB4 ALB GGT2
20 periampullary adenoma 10.2 GGT1 GGT2
21 pancreatitis 10.2
22 hepatic tuberculosis 10.2 ALB GGT1 GGT2
23 leber congenital amaurosis 10.2 ABCB11 CYP7A1 NR1H4 NR1I2
24 bilirubin metabolic disorder 10.1 ABCC2 ALB GGT1 NR1I3
25 ethmoid sinus cancer 10.1 GGT1 GGT2
26 cholestasis, progressive familial intrahepatic, 1 10.1 ABCB11 ABCB4 ATP8B1 GGT1 NR1H4
27 ethmoid sinus adenocarcinoma 10.0 GGT1 GGT2
28 aging 10.0
29 common bile duct disease 9.9 CCK GGT2
30 hepatitis 9.9
31 duodenitis 9.9
32 sickle cell anemia 9.8
33 episodic pain syndrome, familial, 1 9.8
34 gastrointestinal system disease 9.7 ABCB11 ALB CCK GGT1 GGT2 NR1I2
35 liver disease 9.7 ABCB11 ABCB4 ALB ATP8B1 GGT1 NR1H4
36 extrahepatic cholestasis 9.7 ABCB4 ABCC2 ABCC3 CYP7A1 GGT1 SLCO1A2
37 blood group, i system 9.7
38 fibrosis of extraocular muscles, congenital, 1 9.7
39 down syndrome 9.7
40 cystic fibrosis 9.7
41 body mass index quantitative trait locus 11 9.7
42 body mass index quantitative trait locus 9 9.7
43 body mass index quantitative trait locus 8 9.7
44 body mass index quantitative trait locus 1 9.7
45 body mass index quantitative trait locus 4 9.7
46 body mass index quantitative trait locus 10 9.7
47 body mass index quantitative trait locus 7 9.7
48 body mass index quantitative trait locus 12 9.7
49 body mass index quantitative trait locus 14 9.7
50 beta-thalassemia 9.7

Comorbidity relations with Biliary Tract Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Pancreatitis

Graphical network of the top 20 diseases related to Biliary Tract Disease:



Diseases related to Biliary Tract Disease

Symptoms & Phenotypes for Biliary Tract Disease

UMLS symptoms related to Biliary Tract Disease:


digestive system symptom

GenomeRNAi Phenotypes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 ABCC3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.66 GGT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.66 ABCC3 GGT1 GGT2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.66 GGT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.66 ABCB11 ABCC3 GGT1 GGT2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.66 ABCC3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 GGT1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 ABCC3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 ABCC3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.66 ABCC3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.66 ABCB11
12 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.66 GGT2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.66 ABCB11
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.66 GGT1 GGT2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.66 ABCB11
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.66 ABCB11

MGI Mouse Phenotypes related to Biliary Tract Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 NR1H2 NR1H4 NR1I2 NR1I3 SLC25A13 ABCB11
2 liver/biliary system MP:0005370 9.44 NR1H4 NR1I2 NR1I3 SLC25A13 ABCB11 ABCB4

Drugs & Therapeutics for Biliary Tract Disease

Drugs for Biliary Tract Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 503)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 128-13-2 31401
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
8
Remifentanil Approved Phase 4 132875-61-7 60815
9
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
10
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
11
Vancomycin Approved Phase 4,Phase 3,Phase 1 1404-90-6 14969 441141
12
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2 2078-54-8 4943
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Benzocaine Approved, Investigational Phase 4,Phase 2 1994-09-7, 94-09-7 2337
15
Etomidate Approved Phase 4 33125-97-2 667484 36339
16
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
17
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
18
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 1 53608-75-6
19 Nefopam Approved, Investigational Phase 4 13669-70-0
20
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
21
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
22
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
23
Acetaminophen Approved Phase 4 103-90-2 1983
24
Ibuprofen Approved Phase 4 15687-27-1 3672
25
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
26
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
27
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
28
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
29
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
30
Esmolol Approved Phase 4 81147-92-4, 103598-03-4 59768
31
Ephedrine Approved Phase 4 299-42-3 9294
32
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
33
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
34
Ondansetron Approved Phase 4 99614-02-5 4595
35
Tauroursodeoxycholic acid Approved, Investigational Phase 4,Phase 3 14605-22-2 12443252
36
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
37
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
38
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
39
Minocycline Approved, Investigational Phase 4,Phase 1 10118-90-8 5281021
40
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
41
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1 443-48-1 4173
42
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
43
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
44
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
45
Pseudoephedrine Approved Phase 4 90-82-4 7028
46
Tigecycline Approved Phase 4,Phase 1 220620-09-7 5282044
47
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
48
Meperidine Approved Phase 4 57-42-1 4058
49
Secretin Approved, Investigational Phase 4 108153-74-8
50
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253

Interventional clinical trials:

(show top 50) (show all 963)

# Name Status NCT ID Phase Drugs
1 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Unknown status NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
4 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
5 Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy Unknown status NCT02114437 Phase 4
6 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
7 Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized Controlled Trial. Unknown status NCT01052727 Phase 4
8 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
9 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
10 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
11 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
12 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
13 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
14 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
15 Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis Unknown status NCT01998620 Phase 4 Ademetionine 2;Ademetionine 1;Ademetionine 3
16 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
17 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
18 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
19 Spy II Clinical Registry Completed NCT00751998 Phase 4
20 Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01350037 Phase 4 alfentanil;remifentanil
21 Effect IV Ibuprofen and Inflammatory Responses Completed NCT01938040 Phase 4 ibuprofen
22 The Usefulness of Endoscopic Ultrasound-guided Biliary Drainage With a Newly Designed Hybrid Metallic Stent Completed NCT01862198 Phase 4
23 A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982) Completed NCT01728584 Phase 4 Rocuronium;Sugammadex
24 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed NCT01709422 Phase 4 Propofol;Midazolam;Meperidine
25 Cocktail Sedation Containing Propofol Versus Conventional Sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01540084 Phase 4 propofol
26 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
27 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
28 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
29 LaGRA Trial in Laparoscopic Cholecystectomy Completed NCT03394807 Phase 4 Levobupivacaine;Placebo
30 Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy Completed NCT03180229 Phase 4 Granisetron 1 Mg/mL Intravenous Solution
31 Endovenous Lidocaine and Serum Cytokines Concentration Completed NCT02363699 Phase 4 Lidocaine;Saline solution
32 Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Completed NCT02327923 Phase 4 Lidocaine;Esmolol;Paracetamol;Lidocaine;Propofol;Fentanyl;Vecuronium;Atropine;Ephedrine;Morphine;Ketorolac;Ondansetron;Bupivacaine;Tramadol;Neostigmine;Glycopyrrolate
33 Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) Completed NCT02116985 Phase 4
34 Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy Completed NCT01397565 Phase 4
35 Oxidative Stress in Standard Laparoscopic vs Single Port Cholecystectomy Completed NCT01211743 Phase 4
36 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4 Meloxicam
37 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
38 Cholecyst- Versus Cystic Duct Cholangiography During Laparoscopic Cholecystectomy Completed NCT01103570 Phase 4
39 Levobupivacaine During Cholecystectomy Completed NCT00836316 Phase 4 levobupivacaine
40 Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study Completed NCT00562900 Phase 4
41 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
42 Effect of Rowachol on Prevention of Postcholecystectomy Syndrome Completed NCT01765465 Phase 4 Rowachol;Placebo
43 Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
44 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
45 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
46 Preventing Cholestasis Using SMOFLipid® Completed NCT01585935 Phase 4 SMOFLIPID;INTRALIPID
47 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
48 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
49 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
50 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4

Search NIH Clinical Center for Biliary Tract Disease

Cochrane evidence based reviews: biliary tract diseases

Genetic Tests for Biliary Tract Disease

Genetic tests related to Biliary Tract Disease:

# Genetic test Affiliating Genes
1 Biliary Tract Abnormality 28

Anatomical Context for Biliary Tract Disease

MalaCards organs/tissues related to Biliary Tract Disease:

38
Liver, Lung, Pancreas, Testes, T Cells, Breast, Bone

Publications for Biliary Tract Disease

Articles related to Biliary Tract Disease:

(show top 50) (show all 280)
# Title Authors Year
1
Single-incision laparoscopic surgery for biliary tract disease. ( 26811621 )
2016
2
Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures: Retrospective Cohort Analysis of a US Population. ( 26706861 )
2016
3
Risk and Surveillance of Cancers in Primary Biliary Tract Disease. ( 27413366 )
2016
4
Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management. ( 26051390 )
2015
5
Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies. ( 24721739 )
2014
6
Ketamine abuse, biliary tract disease, and secondary sclerosing cholangitis. ( 23695896 )
2013
7
Impact of an acute care surgery model with a dedicated daytime operating room on outcomes and timeliness of care in patients with biliary tract disease. ( 23756774 )
2013
8
Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases. ( 22253524 )
2012
9
Transgastric endoscopic retrograde cholangiopancreatography for the management of biliary tract disease after Roux-en-Y gastric bypass treatment for obesity. ( 22460551 )
2012
10
Role of intraoperative flexible Choledochoscopy in calculous biliary tract disease. ( 22828544 )
2012
11
Endoscopic diagnosis of biliary tract disease. ( 22343346 )
2012
12
Cholangioscopy using a new type of cholangioscope for the diagnosis of biliary tract disease: a case series. ( 22814962 )
2012
13
Imaging of biliary tract disease. ( 21940525 )
2011
14
A stunning year for advances in biliary tract disease. ( 21423005 )
2011
15
Peroral cholangioscopy for diagnosis and therapy of biliary tract disease using an ultra-slim gastroscope. ( 21823068 )
2011
16
Vascular factors, angiogenesis and biliary tract disease. ( 20061944 )
2010
17
Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children. ( 20101777 )
2010
18
Management of biliary tract disease during pregnancy. ( 20193902 )
2010
19
Minimally invasive management of acute biliary tract disease during pregnancy. ( 19606252 )
2009
20
The role of international classification of diseases in assessment of patients with biliary tract disease. ( 19745312 )
2009
21
Farnesoid X receptor agonists in biliary tract disease. ( 19300246 )
2009
22
Double-balloon enteroscopy application in biliary tract disease-its therapeutic and diagnostic functions. ( 18561917 )
2008
23
Management of biliary tract disease during pregnancy: a decision analysis. ( 17713817 )
2008
24
Chlamydia infection as risk factor for pediatric biliary tract disease. ( 18334886 )
2008
25
Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. ( 17063088 )
2006
26
Biliary tract disease as a risk factor for Plesiomonas shigelloides bacteraemia: a nine-year experience in a Hong Kong hospital and review of the literature. ( 15782626 )
2005
27
Bacteriuria in patients with gallbladder and biliary tract diseases. ( 16295397 )
2004
28
Medical versus surgical management of biliary tract disease in pregnancy. ( 15619495 )
2004
29
Diffuse lymphoplasmacytic chronic cholecystitis is highly specific for extrahepatic biliary tract disease but does not distinguish between primary and secondary sclerosing cholangiopathy. ( 14508392 )
2003
30
Lymphoplasmacytic chronic cholecystitis and biliary tract disease in patients with lymphoplasmacytic sclerosing pancreatitis. ( 12657928 )
2003
31
Helicobacter pylori and the risk of benign and malignant biliary tract disease. ( 12879485 )
2003
32
Prenatal diagnosis of liver and biliary tract disease. ( 15001123 )
2003
33
Gallbladder and biliary tract disease in the intensive care unit. ( 12610852 )
2003
34
Biliary tract disease: a rare manifestation of eosinophilic gastroenteritis. ( 12757181 )
2003
35
The role of microorganisms in biliary tract disease. ( 11900683 )
2002
36
Bacteriology and antimicrobial susceptibility in biliary tract disease: an audit of 10-year's experience. ( 12197428 )
2002
37
MR and ultrasound in screening of patients with suspected biliary tract disease. ( 11972468 )
2002
38
Imaging the spectrum of biliary tract disease. ( 12479714 )
2002
39
Helicobacter pylori and the risk of benign and malignant biliary tract disease. ( 12404289 )
2002
40
Biliary tract disease and acute non-A-E hepatitis in Hong Kong: prospective study. ( 11514745 )
2001
41
Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas. ( 11347977 )
2001
42
Endoscopic management of biliary tract disease. ( 17031203 )
2001
43
Endoscopic therapy for biliary tract disease before orthotopic liver transplantation. ( 11175974 )
2001
44
Role of operative flexible choledochoscopy in calculous biliary tract disease. ( 10881633 )
2000
45
Management of biliary tract disease in heart and lung transplant patients. ( 11015098 )
2000
46
Recommendations for management of liver and biliary tract disease in cystic fibrosis. Cystic Fibrosis Foundation Hepatobiliary Disease Consensus Group. ( 9934970 )
1999
47
The use of magnetic resonance cholangiopancreatography in the management of biliary tract disease in pregnancy. ( 15512428 )
1999
48
Experience with percutaneous transhepatic cholangioscopy (PTCS) in the management of biliary tract disease. ( 10594265 )
1999
49
Endoscopic management of biliary tract disease. ( 17023988 )
1999
50
A prospective comparison of magnetic resonance cholangiopancreatography with endoscopic retrograde cholangiopancreatography in the evaluation of patients with suspected biliary tract disease. ( 10484218 )
1999

Variations for Biliary Tract Disease

Expression for Biliary Tract Disease

Search GEO for disease gene expression data for Biliary Tract Disease.

Pathways for Biliary Tract Disease

Pathways related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 ABCB11 ABCB4 ABCC3 ALB CYP7A1 CYP8B1
2
Show member pathways
13.26 ABCB4 ABCC2 ABCC3 ABCC4 ALB ATP8B1
3 12.39 ABCC2 ABCC3 ABCC4 NR1H2
4
Show member pathways
12.17 ABCB11 ABCC3 ALB CYP7A1 CYP8B1 NR1H4
5 11.99 ABCC2 ABCC3 ABCC4 GGT1 GGT2
6
Show member pathways
11.9 ABCB11 ABCB4 ABCC2 SLC10A1 SLCO1A2
7
Show member pathways
11.75 NR1H2 NR1H4 NR1I2 NR1I3
8
Show member pathways
11.71 ABCB11 ABCC2 ABCC4 SLCO1A2
9 11.71 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 CYP7A1
10
Show member pathways
11.65 ABCC2 ABCC3 ABCC4
11
Show member pathways
11.48 ABCC2 NR1I2 NR1I3
12 11.22 ABCC2 ABCC3 NR1I3
13 11.19 ABCC2 ABCC3 ABCC4
14 11.07 ABCC2 ABCC3 ABCC4
15 11.01 ABCB11 ABCB4 CYP7A1 CYP8B1 NR1H4 SLC10A1
16 10.97 GGT1 GGT2
17
Show member pathways
10.97 ABCC2 ABCC3 ABCC4 SLCO1A2
18 10.89 ABCC2 ABCC3 ABCC4
19 10.89 ABCB11 ABCC2 ABCC3 ABCC4 CYP7A1 NR1H4
20 10.82 ABCB11 ABCB4 ABCC2 ABCC3 CYP7A1 CYP8B1
21 10.77 ABCC3 NR1I2
22 10.7 ABCC2 NR1I2
23 10.57 ABCC2 ABCC3

GO Terms for Biliary Tract Disease

Cellular components related to Biliary Tract Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.61 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1
2 basolateral plasma membrane GO:0016323 9.56 ABCC3 ABCC4 SLC10A1 SLC51B
3 brush border membrane GO:0031526 9.33 ABCB4 ABCC2 ATP8B1
4 intercellular canaliculus GO:0046581 8.8 ABCB11 ABCB4 ABCC2

Biological processes related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.86 NR1H2 NR1H4 NR1I2 NR1I3
2 transmembrane transport GO:0055085 9.81 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 SLC10A1
3 steroid hormone mediated signaling pathway GO:0043401 9.71 NR1H2 NR1H4 NR1I2 NR1I3
4 intracellular receptor signaling pathway GO:0030522 9.69 NR1H4 NR1I2 NR1I3
5 bile acid biosynthetic process GO:0006699 9.63 ABCB11 CYP7A1 CYP8B1
6 phospholipid translocation GO:0045332 9.62 ABCB4 ATP8B1
7 organic anion transport GO:0015711 9.61 ABCC2 SLCO1A2
8 response to glucagon GO:0033762 9.61 ABCB4 ABCC2
9 bile acid metabolic process GO:0008206 9.6 ATP8B1 NR1H4
10 glutathione catabolic process GO:0006751 9.59 GGT1 GGT2
11 zymogen activation GO:0031638 9.58 GGT1 GGT2
12 regulation of cholesterol homeostasis GO:2000188 9.58 NR1H2 NR1H4
13 leukotriene D4 biosynthetic process GO:1901750 9.57 GGT1 GGT2
14 drug transmembrane transport GO:0006855 9.56 ABCB4 ABCC2 ABCC3 ATP8B1
15 bile acid secretion GO:0032782 9.55 ABCB4 SLC51B
16 response to antineoplastic agent GO:0097327 9.54 ABCB4 ABCC2
17 xenobiotic transport GO:0042908 9.54 ABCB4 ABCC3 NR1I2
18 drug export GO:0046618 9.52 ABCB4 NR1I2
19 canalicular bile acid transport GO:0015722 9.5 ABCB11 ABCC2 ABCC3
20 positive regulation of cholesterol transport GO:0032376 9.49 ABCB4 NR1H2
21 regulation of bile acid biosynthetic process GO:0070857 9.48 CYP7A1 NR1H4
22 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.26 ABCB11 ABCC2 ABCC3 ABCC4
23 bile acid and bile salt transport GO:0015721 9.23 ABCB11 ABCC3 ALB ATP8B1 NR1H4 SLC10A1
24 transport GO:0006810 10.13 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4 ATP8B1

Molecular functions related to Biliary Tract Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.8 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4
2 transporter activity GO:0005215 9.78 ABCB11 ABCC2 ABCC3 SLC25A13
3 steroid hormone receptor activity GO:0003707 9.62 NR1H2 NR1H4 NR1I2 NR1I3
4 organic anion transmembrane transporter activity GO:0008514 9.61 ABCC2 ABCC3 SLCO1A2
5 bile acid transmembrane transporter activity GO:0015125 9.54 SLC10A1 SLC51B SLCO1A2
6 retinoid X receptor binding GO:0046965 9.52 NR1H2 NR1H4
7 glutathione hydrolase activity GO:0036374 9.51 GGT1 GGT2
8 xenobiotic transmembrane transporting ATPase activity GO:0008559 9.49 ABCB4 ABCC3
9 bile acid-exporting ATPase activity GO:0015432 9.46 ABCB11 ABCC3
10 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.43 ABCC2 ABCC3 ABCC4
11 thyroid hormone receptor activity GO:0004887 9.33 NR1H4 NR1I2 NR1I3
12 nuclear receptor activity GO:0004879 9.26 NR1H2 NR1H4 NR1I2 NR1I3
13 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.02 ABCB11 ABCB4 ABCC2 ABCC3 ABCC4

Sources for Biliary Tract Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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