MCID: BLR007
MIFTS: 50

Biliary Tract Neoplasm

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Biliary Tract Neoplasm

MalaCards integrated aliases for Biliary Tract Neoplasm:

Name: Biliary Tract Neoplasm 12 29 14 69
Biliary Tract Cancer 50 52 69
Carcinoma of Extrahepatic Bile Duct 12 69
Extrahepatic Bile Duct Carcinoma 12 14
Extrahepatic Bile Duct Neoplasm 12 69
Malignant Tumor of Extrahepatic Bile Duct 69
Neoplasm of Extrahepatic Bile Ducts 12
Tumor of the Extrahepatic Bile Duct 12
Bile Duct Extrahepatic Carcinoma 52
Extrahepatic Bile Duct Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050625 DOID:4682
NCIt 47 C4441 C3860
ICD10 33 C24.0

Summaries for Biliary Tract Neoplasm

Disease Ontology : 12 A hepatobiliary benign neoplasm located in the biliary tract.

MalaCards based summary : Biliary Tract Neoplasm, also known as biliary tract cancer, is related to klatskin's tumor and gallbladder cancer. An important gene associated with Biliary Tract Neoplasm is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are HIV Life Cycle and Metabolism of proteins. The drugs Pancrelipase and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and pancreas, and related phenotypes are Decreased viability and cardiovascular system

Related Diseases for Biliary Tract Neoplasm

Diseases related to Biliary Tract Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
id Related Disease Score Top Affiliating Genes
1 klatskin's tumor 32.4 MUC1 MUC4
2 gallbladder cancer 28.6 CDKN2A CDX2 HRAS KRAS MUC2 SMAD4
3 extrahepatic bile duct adenocarcinoma 11.2
4 extrahepatic bile duct small cell adenocarcinoma 11.2
5 extrahepatic bile duct adenoma 11.2
6 biliary papillomatosis 10.9
7 gallbladder adenoma 10.9
8 bile duct carcinoma 10.8
9 idiopathic central precocious puberty 10.7 MUC2 MUC4
10 situs inversus 10.6 MUC1 MUC2
11 urinary system disease 10.6 MUC1 MUC2
12 testicular trophoblastic tumor 10.6 MUC1 MUC2
13 ovarian mucinous adenocarcinoma 10.5 MUC1 MUC2
14 papilloma 10.5 MUC1 MUC4
15 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.5 CDKN2A MUC1
16 bladder colloid adenocarcinoma 10.5 CDKN2A MUC1
17 pulmonary type ovarian small cell carcinoma 10.5 CDKN2A MUC1
18 persian gulf syndrome 10.5 CDKN2A MUC1
19 uremic neuropathy 10.5 MUC1 MUC4
20 diffuse meningeal melanocytosis 10.5 CDKN2A MUC1
21 encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 10.5 MUC1 MUC2
22 spindle cell liposarcoma 10.5 CDKN2A MUC1
23 cervical adenoid cystic carcinoma 10.5 CDKN2A TP53
24 neurofibroma of the esophagus 10.5 CDKN2A MUC1
25 bile duct clear cell adenocarcinoma 10.5 CDX2 MUC2
26 plummer vinson syndrome 10.4 CDKN2A MUC1
27 leiomyoma cutis 10.4 CDKN2A TP53
28 liver disease 10.4 MUC1 MUC4
29 anal squamous cell carcinoma 10.4 CDKN2A TP53
30 fibrous meningioma 10.4 CDKN2A HRAS
31 rectum squamous cell carcinoma 10.4 CDKN2A TP53
32 breast myoepitheliosis 10.4 CDKN2A TP53
33 ritter's disease 10.4 CDKN2A TP53
34 coccidiosis 10.4 CDKN2A TP53
35 breast mucinous cystadenocarcinoma 10.4 CDX2 MUC2
36 duodenum cancer 10.4 CDKN2A TP53
37 penis paget's disease 10.4 CDKN2A TP53
38 vulval paget's disease 10.4 CDKN2A HRAS
39 cholangitis 10.4 CDX2 MUC2
40 retinal detachment 10.4 CDKN2A TP53
41 larynx carcinoma in situ 10.4 CDKN2A TP53
42 phalanx chondroma 10.4 CDKN2A TP53
43 phobic disorder 10.4 CDKN2A MUC1
44 orbital lymphoma 10.4 CDKN2A TP53
45 non-suppurative otitis media 10.4 CDKN2A TP53
46 pleural empyema 10.4 MUC1 TP53
47 pyloric antrum cancer 10.4 CDX2 MUC2
48 pancreatic agenesis 10.4 CDKN2A TP53
49 secondary pulmonary hemosiderosis 10.4 CDKN2A TP53
50 intracranial sinus thrombosis 10.4 CDX2 MUC2

Comorbidity relations with Biliary Tract Neoplasm via Phenotypic Disease Network (PDN):


Acute Pancreatitis Cholangitis
Cholestasis Deficiency Anemia
Intrahepatic Gall Duct Cancer Pancreatic Cancer
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Biliary Tract Neoplasm:



Diseases related to Biliary Tract Neoplasm

Symptoms & Phenotypes for Biliary Tract Neoplasm

GenomeRNAi Phenotypes related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.36 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.36 KRAS
3 Decreased viability GR00221-A-1 9.36 HRAS KRAS
4 Decreased viability GR00221-A-2 9.36 HRAS KRAS
5 Decreased viability GR00221-A-3 9.36 HRAS
6 Decreased viability GR00301-A 9.36 KRAS
7 Decreased viability GR00381-A-1 9.36 KRAS

MGI Mouse Phenotypes related to Biliary Tract Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 CDKN2A CDX2 HRAS KRAS MUC2 SMAD4
2 digestive/alimentary MP:0005381 9.73 KRAS MUC2 SMAD4 TP53 CDKN2A CDX2
3 endocrine/exocrine gland MP:0005379 9.7 CDKN2A CDX2 HRAS KRAS MUC2 SMAD4
4 neoplasm MP:0002006 9.5 CDKN2A CDX2 HRAS KRAS MUC2 SMAD4
5 skeleton MP:0005390 9.1 CDKN2A CDX2 HRAS KRAS SMAD4 TP53

Drugs & Therapeutics for Biliary Tract Neoplasm

Drugs for Biliary Tract Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 211)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved Phase 4,Phase 2,Phase 1 53608-75-6
2
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
3
Desflurane Approved Phase 4 57041-67-5 42113
4
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
7 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
8 pancreatin Phase 4,Phase 2,Phase 1
9 Central Nervous System Depressants Phase 4
10 Gastrointestinal Agents Phase 4,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anesthetics Phase 4
13 Anesthetics, General Phase 4
14 Anesthetics, Inhalation Phase 4
15 Platelet Aggregation Inhibitors Phase 4
16 Analgesics Phase 4,Phase 1
17 Analgesics, Non-Narcotic Phase 4,Phase 1
18 Anti-Inflammatory Agents Phase 4
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4
20 Antirheumatic Agents Phase 4
21 Cyclooxygenase 2 Inhibitors Phase 4
22 Cyclooxygenase Inhibitors Phase 4
23 arginine Nutraceutical Phase 4
24 Omega 3 Fatty Acid Nutraceutical Phase 4
25
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
26
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
27
Fluorouracil Approved Phase 2, Phase 3, Phase 1 51-21-8 3385
28
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
29
Irinotecan Approved, Investigational Phase 2, Phase 3,Phase 1 97682-44-5, 100286-90-6 60838
30
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 84093 441203 2767
31
Trioxsalen Approved Phase 3,Phase 2 3902-71-4 5585
32
Epirubicin Approved Phase 3,Phase 1,Phase 2 56420-45-2 41867
33
Somatostatin Approved Phase 3 38916-34-6, 51110-01-1 53481605
34
Tegafur Approved Phase 3,Phase 2,Phase 1 17902-23-7 5386
35
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
36
Citalopram Approved Phase 3 59729-33-8 2771
37
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
39
Cediranib Investigational Phase 2, Phase 3 288383-20-0 9933475
40 Anti-Infective Agents Phase 2, Phase 3, Phase 1
41 Antimetabolites Phase 2, Phase 3, Phase 1
42 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1
43 Antiviral Agents Phase 2, Phase 3, Phase 1
44 Immunosuppressive Agents Phase 2, Phase 3, Phase 1
45 Dermatologic Agents Phase 3,Phase 2,Phase 1
46 Photosensitizing Agents Phase 3,Phase 2,Phase 1
47 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
48 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
49 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
50 Antidotes Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 333)

id Name Status NCT ID Phase Drugs
1 Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction Unknown status NCT01514214 Phase 4
2 Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy Unknown status NCT01256047 Phase 4
3 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
4 Radiofrequency Ablation for Malignant Biliary Obstruction Completed NCT01758341 Phase 4
5 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
6 RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction Completed NCT00980889 Phase 4
7 Comparing Covered Self-expandable Metallic Stent (SEMS) Above/Across the Sphincter of Oddi Completed NCT01041612 Phase 4
8 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
9 Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Completed NCT01256034 Phase 4
10 Spy II Clinical Registry Completed NCT00751998 Phase 4
11 Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery Recruiting NCT02174575 Phase 4 Sevoflurane;Desflurane
12 Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer Enrolling by invitation NCT01111591 Phase 4 Cox2 inhibitor (Celecoxib)
13 The Effect of Individualized Precision Therapy Programs in Patients With BTC Not yet recruiting NCT02943031 Phase 4
14 Quality of Life After BDA or Stents to Treat Biliary Obstruction in Pancreas Cancer Terminated NCT01887041 Phase 4
15 Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy Unknown status NCT00809081 Phase 3
16 Cediranib Versus Placebo Plus Cisplatin/Gemcitabine Chemotherapy for Patients With Advanced Biliary Tract Cancers Completed NCT00939848 Phase 2, Phase 3 gemcitabine;cisplatin;Placebo;cisplatin;cediranib;gemcitabine
17 Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy Completed NCT01731821 Phase 3
18 Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer Completed NCT00363584 Phase 3 capecitabine
19 Early Palliative Care on Quality of Life of Advanced Cancer Patients Completed NCT02988635 Phase 3
20 Gemcitabine Hydrochloride and Oxaliplatin or Observation in Treating Patients With Biliary Tract Cancer That Has Been Removed by Surgery Completed NCT01313377 Phase 3 gemcitabine hydrochloride;oxaliplatin
21 Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors Completed NCT00262769 Phase 3 cisplatin;gemcitabine hydrochloride
22 Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery Completed NCT00304135 Phase 2, Phase 3 cisplatin;gemcitabine hydrochloride;oxaliplatin
23 Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery Completed NCT00513539 Phase 3 porfimer sodium
24 Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block. Completed NCT00391183 Phase 2, Phase 3
25 New Chemotherapy Regimen in the Treatment of Advanced Gallbladder Carcinoma Completed NCT01053390 Phase 3 Somatostatin;epirubicin, cisplatin, LV(Leucovorin)、 5-FU(5-Fluorouracil)
26 Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms Completed NCT01640522 Phase 3
27 Home Enteral Nutrition in Malnourished Patients With Gastrointestinal Cancer Completed NCT02664974 Phase 3
28 Prospective Study Comparing EUS vs ERCP Stent Insertion for Malignant Biliary Obstruction Completed NCT01421836 Phase 2, Phase 3
29 Gemcitabine/Oxaliplatin (GEMOX) With or Without Erlotinib (Tarceva) in Advanced Biliary Tract Carcinoma Completed NCT01149122 Phase 3 Gemcitabine/Oxaliplatin;Gemcitabine/Oxaliplatin with Erlotinib (Tarceva)
30 Active Symptom Control Alone or With mFOLFOX Chemotherapy for Locally Advanced/ Metastatic Biliary Tract Cancers Recruiting NCT01926236 Phase 3 L-folinic acid;5 FU;Oxaliplatin
31 Effect of Early Management on PAin and DEpression in Patients With PancreatoBiliary Cancer, EPADE-PB Recruiting NCT01589328 Phase 3
32 Early Palliative Care in Patients With Metastatic Upper Gastrointestinal Cancers Treated With First-line Chemotherapy Recruiting NCT02853474 Phase 3
33 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer Recruiting NCT02170090 Phase 3 Gemcitabine;Cisplatin;Capecitabine
34 Study of GEMOX(Gemcitabine/Oxaliplatin) Versus XELOX(Xeloda/Oxaliplatin) in Advanced Biliary Tract Carcinoma Recruiting NCT01470443 Phase 3 Oxaliplatin;Oxaliplatin
35 Safety and Efficacy of Modified Folfirinox Versus Gemcis in Bile Duct Tumours Recruiting NCT02591030 Phase 2, Phase 3 GEMCIS;mFolfirinox
36 Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma Recruiting NCT01755013 Phase 2, Phase 3
37 GEM/Cisplatin/S-1 vs GEM/Cisplatin for Biliary Tract Cancer Active, not recruiting NCT02182778 Phase 3 Gemcitabine/Cisplatin;Gemcitabine/Cisplatin /S-1
38 X-MAS Biliary Study With Covered Biliary Stent Active, not recruiting NCT01899976 Phase 3
39 Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers Active, not recruiting NCT02349412 Phase 3
40 Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer Not yet recruiting NCT03093870 Phase 2, Phase 3 Varlitinib;Capecitabine;Placebo (for Varlitinib)
41 Study of SPARC1507 Not yet recruiting NCT02597465 Phase 3 SPARC1507;Reference1507
42 Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers Not yet recruiting NCT02867865 Phase 2, Phase 3 Gemcitabine;Cisplatin
43 Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma Not yet recruiting NCT03086993 Phase 2, Phase 3 Cisplatin and Gemcitabine
44 XL119 Versus 5-Fluorouracil (5-FU) Plus Leucovorin (LV) in Subjects With Advanced Biliary Tumors Terminated NCT00090025 Phase 3 becatecarin;5-Fluorouracil Plus Leucovorin
45 Gemcitabine With or Without Capecitabine in Treating Patients With Locally Advanced, Unresectable, or Metastatic Biliary Cancer Terminated NCT00658593 Phase 3 capecitabine;gemcitabine hydrochloride
46 Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal Cancer Terminated NCT00387348 Phase 3 escitalopram oxalate;Placebo
47 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
48 Stent Placement With or Without Photodynamic Therapy Using Porfimer Sodium as Palliative Treatment in Treating Patients With Stage III or Stage IV Cholangiocarcinoma That Cannot Be Removed By Surgery Withdrawn NCT00253617 Phase 3 porfimer sodium
49 Immunotherapy Using Precision T Cells Specific to Personalized Neo-antigen for the Treatment of Advanced Malignant Tumor of Biliary Tract Unknown status NCT02632019 Phase 1, Phase 2 Gemcitabine
50 Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm Unknown status NCT02528526 Phase 1, Phase 2 OXY111A

Search NIH Clinical Center for Biliary Tract Neoplasm

Genetic Tests for Biliary Tract Neoplasm

Genetic tests related to Biliary Tract Neoplasm:

id Genetic test Affiliating Genes
1 Biliary Tract Neoplasm 29

Anatomical Context for Biliary Tract Neoplasm

MalaCards organs/tissues related to Biliary Tract Neoplasm:

39
Liver, Lung, Pancreas, Testes, Breast, T Cells, Endothelial

Publications for Biliary Tract Neoplasm

Articles related to Biliary Tract Neoplasm:

id Title Authors Year
1
Imaging features and appropriate treatment strategy of a rare biliary tract neoplasm. ( 23823837 )
2013
2
Epidemiological aspects of gallbladder and biliary tract neoplasm. ( 5008636 )
1972

Variations for Biliary Tract Neoplasm

Cosmic variations for Biliary Tract Neoplasm:

9 (show top 50) (show all 231)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM4172016 TSC1 biliary tract,bile duct,carcinoma,NS c.737+1G>A p.? 14
2 COSM308173 TRIM28 biliary tract,bile duct,carcinoma,NS c.1475G>T p.R492L 14
3 COSM44463 TP53 biliary tract,bile duct,carcinoma,NS c.848G>T p.R283L 14
4 COSM10656 TP53 biliary tract,bile duct,carcinoma,NS c.742C>T p.R248W 14
5 COSM44329 TP53 biliary tract,bile duct,carcinoma,NS c.470T>A p.V157D 14
6 COSM10812 TP53 biliary tract,bile duct,carcinoma,NS c.722C>T p.S241F 14
7 COSM10705 TP53 biliary tract,bile duct,carcinoma,NS c.586C>T p.R196* 14
8 COSM43687 TP53 biliary tract,bile duct,carcinoma,NS c.641A>G p.H214R 14
9 COSM10704 TP53 biliary tract,bile duct,carcinoma,NS c.844C>T p.R282W 14
10 COSM10663 TP53 biliary tract,bile duct,carcinoma,NS c.916C>T p.R306* 14
11 COSM10660 TP53 biliary tract,bile duct,carcinoma,NS c.818G>A p.R273H 14
12 COSM10654 TP53 biliary tract,bile duct,carcinoma,NS c.637C>T p.R213* 14
13 COSM44326 TP53 biliary tract,bile duct,carcinoma,NS c.706T>C p.Y236H 14
14 COSM45393 TP53 biliary tract,bile duct,carcinoma,NS c.793C>A p.L265M 14
15 COSM44114 TP53 biliary tract,bile duct,carcinoma,NS c.826G>A p.A276T 14
16 COSM10725 TP53 biliary tract,bile duct,carcinoma,NS c.701A>G p.Y234C 14
17 COSM43842 TP53 biliary tract,bile duct,carcinoma,NS c.770T>C p.L257P 14
18 COSM44823 TP53 biliary tract,bile duct,carcinoma,NS c.981T>G p.Y327* 14
19 COSM10731 TP53 biliary tract,bile duct,carcinoma,NS c.707A>G p.Y236C 14
20 COSM10662 TP53 biliary tract,bile duct,carcinoma,NS c.743G>A p.R248Q 14
21 COSM10722 TP53 biliary tract,bile duct,carcinoma,NS c.853G>A p.E285K 14
22 COSM43778 TP53 biliary tract,bile duct,carcinoma,NS c.713G>T p.C238F 14
23 COSM44426 TP53 biliary tract,bile duct,carcinoma,NS c.568C>G p.P190A 14
24 COSM44309 TP53 biliary tract,bile duct,carcinoma,NS c.440T>G p.V147G 14
25 COSM44785 TP53 biliary tract,bile duct,carcinoma,NS c.702C>G p.Y234* 14
26 COSM11582 TP53 biliary tract,bile duct,carcinoma,NS c.395A>G p.K132R 14
27 COSM43751 TP53 biliary tract,bile duct,carcinoma,NS c.673-1G>A p.? 14
28 COSM44523 TP53 biliary tract,bile duct,carcinoma,NS c.863A>G p.N288S 14
29 COSM43635 TP53 biliary tract,bile duct,carcinoma,NS c.536A>T p.H179L 14
30 COSM10727 TP53 biliary tract,bile duct,carcinoma,NS c.438G>A p.W146* 14
31 COSM44786 TP53 biliary tract,bile duct,carcinoma,NS c.694A>C p.I232L 14
32 COSM10648 TP53 biliary tract,bile duct,carcinoma,NS c.524G>A p.R175H 14
33 COSM43596 TP53 biliary tract,bile duct,carcinoma,NS c.841G>A p.D281N 14
34 COSM11090 TP53 biliary tract,bile duct,carcinoma,NS c.541C>T p.R181C 14
35 COSM10690 TP53 biliary tract,bile duct,carcinoma,NS c.473G>A p.R158H 14
36 COSM44262 TP53 biliary tract,bile duct,carcinoma,NS c.808T>C p.F270L 14
37 COSM11078 TP53 biliary tract,bile duct,carcinoma,NS c.1027G>T p.E343* 14
38 COSM10659 TP53 biliary tract,bile duct,carcinoma,NS c.817C>T p.R273C 14
39 COSM11356 TP53 biliary tract,bile duct,carcinoma,NS c.726C>G p.C242W 14
40 COSM43947 TP53 biliary tract,bile duct,carcinoma,NS c.614A>G p.Y205C 14
41 COSM10883 TP53 biliary tract,bile duct,carcinoma,NS c.731G>A p.G244D 14
42 COSM10672 TP53 biliary tract,bile duct,carcinoma,NS c.577C>T p.H193Y 14
43 COSM11355 TP53 biliary tract,bile duct,carcinoma,NS c.737T>C p.M246T 14
44 COSM44226 TP53 biliary tract,bile duct,carcinoma,NS c.380C>T p.S127F 14
45 COSM10893 TP53 biliary tract,bile duct,carcinoma,NS c.824G>A p.C275Y 14
46 COSM45025 TP53 biliary tract,bile duct,carcinoma,NS c.488A>C p.Y163S 14
47 COSM10738 TP53 biliary tract,bile duct,carcinoma,NS c.542G>A p.R181H 14
48 COSM44623 TP53 biliary tract,bile duct,carcinoma,NS c.487T>A p.Y163N 14
49 COSM44271 TP53 biliary tract,bile duct,carcinoma,NS c.688A>C p.T230P 14
50 COSM10742 TP53 biliary tract,bile duct,carcinoma,NS c.578A>G p.H193R 14

Expression for Biliary Tract Neoplasm

Search GEO for disease gene expression data for Biliary Tract Neoplasm.

Pathways for Biliary Tract Neoplasm

Pathways related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 HRAS KRAS MUC1 MUC2 MUC4 SMAD4
2
Show member pathways
13.52 CDKN2A CDX2 MUC1 MUC2 MUC4 SMAD4
3
Show member pathways
12.66 CDKN2A HRAS KRAS TP53
4 12.4 CDKN2A HRAS KRAS SMAD4 TP53
5
Show member pathways
12.32 CDKN2A HRAS KRAS SMAD4 TP53
6 12.3 CDKN2A HRAS KRAS TP53
7
Show member pathways
12.28 HRAS KRAS MUC1 TP53
8
Show member pathways
12.24 HRAS KRAS TP53
9 12.24 CDKN2A SMAD4 TP53
10
Show member pathways
12.19 HRAS KRAS TP53
11 12.18 HRAS KRAS TP53
12
Show member pathways
12.13 MUC1 MUC2 MUC4
13
Show member pathways
12.07 HRAS KRAS TP53
14
Show member pathways
12.07 HRAS KRAS MUC1 MUC2 MUC4
15 12.06 KRAS SMAD4 TP53
16 12.06 CDKN2A HRAS KRAS TP53
17
Show member pathways
12.05 HRAS KRAS TP53
18 12.01 KRAS SMAD4 TP53
19
Show member pathways
12 HRAS KRAS TP53
20
Show member pathways
12 HRAS KRAS TP53
21
Show member pathways
11.97 MUC1 MUC2 MUC4
22 11.96 CDKN2A HRAS KRAS SMAD4 TP53
23 11.94 CDKN2A SMAD4 TP53
24 11.94 HRAS KRAS SMAD4
25
Show member pathways
11.93 HRAS KRAS SMAD4
26 11.93 HRAS KRAS SMAD4
27 11.91 CDKN2A KRAS TP53
28
Show member pathways
11.9 HRAS KRAS TP53
29 11.89 HRAS KRAS TP53
30 11.83 HRAS KRAS TP53
31 11.82 HRAS KRAS TP53
32
Show member pathways
11.77 MUC1 MUC2 MUC4
33 11.71 HRAS KRAS SMAD4
34 11.71 CDKN2A HRAS KRAS TP53
35 11.65 CDKN2A HRAS SMAD4 TP53
36 11.5 HRAS KRAS TP53
37 11.48 HRAS KRAS TP53
38 11.24 HRAS KRAS
39 11.21 CDKN2A TP53
40 11.18 HRAS KRAS
41
Show member pathways
11.16 HRAS KRAS
42 11.12 CDKN2A HRAS KRAS TP53
43
Show member pathways
11.11 HRAS KRAS
44 11.09 HRAS KRAS SMAD4
45 11.08 CDKN2A HRAS KRAS SMAD4 TP53
46 11.05 HRAS KRAS
47 11.02 HRAS KRAS
48 11.02 CDKN2A TP53
49
Show member pathways
11.01 CDKN2A TP53
50 10.99 MUC2 SMAD4

GO Terms for Biliary Tract Neoplasm

Cellular components related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.13 MUC1 SMAD4 TP53
2 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC4

Biological processes related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.87 CDKN2A CDX2 SMAD4 TP53
2 negative regulation of cell proliferation GO:0008285 9.78 CDKN2A HRAS SMAD4 TP53
3 axon guidance GO:0007411 9.73 HRAS KRAS SMAD4
4 cell cycle arrest GO:0007050 9.69 CDKN2A HRAS TP53
5 negative regulation of cell growth GO:0030308 9.63 CDKN2A SMAD4 TP53
6 intrinsic apoptotic signaling pathway GO:0097193 9.58 HRAS TP53
7 cell aging GO:0007569 9.58 HRAS TP53
8 cellular response to gamma radiation GO:0071480 9.55 HRAS TP53
9 cellular senescence GO:0090398 9.54 CDKN2A HRAS
10 positive regulation of gene expression GO:0010628 9.54 HRAS KRAS TP53
11 regulation of long-term neuronal synaptic plasticity GO:0048169 9.52 HRAS KRAS
12 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 MUC1 TP53
13 maintenance of gastrointestinal epithelium GO:0030277 9.43 MUC2 MUC4
14 replicative senescence GO:0090399 9.4 CDKN2A TP53
15 O-glycan processing GO:0016266 9.33 MUC1 MUC2 MUC4
16 positive regulation of cellular senescence GO:2000774 9.32 CDKN2A KRAS
17 response to isolation stress GO:0035900 9.26 HRAS KRAS
18 Ras protein signal transduction GO:0007265 9.26 CDKN2A HRAS KRAS TP53
19 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 HRAS KRAS MUC1 MUC2 MUC4

Molecular functions related to Biliary Tract Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.32 TP53

Sources for Biliary Tract Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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