MCID: BNS003
MIFTS: 40

Binswanger's Disease

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Binswanger's Disease

MalaCards integrated aliases for Binswanger's Disease:

Name: Binswanger's Disease 50 51
Multi-Infarct Dementia 50 51 69
Dementia Multi-Infarct 50 52
Binswanger Disease 52 69
Dementia - Multi-Infarct 51

Classifications:



External Ids:

ICD10 33 F01.1

Summaries for Binswanger's Disease

NINDS : 51 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Binswanger's Disease, also known as multi-infarct dementia, is related to cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 and vascular dementia. An important gene associated with Binswanger's Disease is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Acetaminophen and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and smooth muscle, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 50 binswanger's disease is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. most affected people experience progressive memory loss and deterioration of intellectual abilities (dementia); urinary urgency or incontinence; and an abnormally slow, unsteady gait (style of walking). while there is no cure, the progression of binswanger's disease can be slowed with healthy lifestyle choices. treatment is based on the signs and symptoms present in each person. last updated: 10/8/2015

Related Diseases for Binswanger's Disease

Diseases related to Binswanger's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 11.6
2 vascular dementia 11.4
3 malignant ovarian mixed epithelial neoplasm 10.9 CHGA SYP
4 ampulla of vater small cell carcinoma 10.8 CHGA SYP
5 ludwig's angina 10.8 CHGA SYP
6 signet ring cell intrahepatic cholangiocarcinoma 10.8 CHGA SYP
7 childhood choriocarcinoma of the ovary 10.8 CHGA SYP
8 osteoblastoma 10.8 CHGA SYP
9 esophagus adenocarcinoma 10.8 CHGA SYP
10 basophilic carcinoma 10.8 CHGA SYP
11 cystitis cystica 10.8 CHGA SYP
12 small intestine cancer, childhood 10.8 CHGA SYP
13 neurogenic thoracic outlet syndrome 10.8 CHGA SYP
14 breast apocrine carcinoma in situ 10.8 SST SYP
15 aicardi-goutieres syndrome 10.8 CHGA SYP
16 diffuse infiltrative lymphocytosis syndrome 10.8 CHGA SYP
17 congenital granular cell tumor 10.8 CHGA SYP
18 pemphigus foliaceus 10.8 SST SYP
19 mast cell neoplasm 10.8 CHGA SYP
20 diffuse lipomatosis 10.8 CHGA SYP
21 neuritis 10.8 SST SYP
22 primary syphilis 10.8 CHGA SST
23 bone giant cell sarcoma 10.8 CHGA SST
24 pleomorphic xanthoastrocytoma 10.8 CHGA SYP
25 devriendt syndrome 10.8 GFAP SYP
26 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 10.8 GFAP SYP
27 thyroid sarcoma 10.8 CHGA SYP
28 dystonia 10.8 GFAP SYP
29 premature aging syndrome, penttinen type 10.7 ACTC1 NOTCH3
30 chilaiditi syndrome 10.7 GFAP SYP
31 anaplastic plasmacytoma 10.7 ACTC1 GFAP
32 retinal detachment 10.7 ACTC1 SYP
33 cerebellar astrocytoma 10.7 GFAP SYP
34 esophagus leiomyosarcoma 10.7 ACTC1 GFAP
35 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.7 GFAP SYP
36 brain glioma 10.7 GFAP SYP
37 spleen angiosarcoma 10.7 ACTC1 GFAP
38 cauda equina intradural extramedullary astrocytoma 10.7 GFAP SYP
39 laryngeal neuroendocrine tumor 10.7 ACTC1 GFAP
40 adenofibroma 10.7 GFAP SYP
41 central nervous system hematologic cancer 10.7 CHGA SYP
42 rh isoimmunization 10.7 GFAP SYP
43 pleural empyema 10.7 GFAP SYP
44 pneumonia 10.7 CHGA SYP
45 cauda equina neoplasm 10.7 GFAP SYP
46 axonal neuropathy 10.7 GFAP SYP
47 pyoderma 10.7 CHGA GFAP
48 anaplastic oligodendroglioma 10.7 GFAP SYP
49 ethmoid sinus schneiderian papilloma 10.7 CHGA SYP
50 tabes dorsalis 10.7 SST SYP

Graphical network of the top 20 diseases related to Binswanger's Disease:



Diseases related to Binswanger's Disease

Symptoms & Phenotypes for Binswanger's Disease

MGI Mouse Phenotypes related to Binswanger's Disease:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 CRH APOE GFAP APP ACHE PLP1
2 growth/size/body region MP:0005378 10.23 ACTC1 CHGA CRH APOE GFAP APP
3 homeostasis/metabolism MP:0005376 10.21 ACTC1 CHGA CRH APOE GFAP APP
4 mortality/aging MP:0010768 10.15 CHGA ACTC1 APOE GFAP APP ACHE
5 cellular MP:0005384 10.13 ACTC1 CRH APOE APP GFAP PLP1
6 cardiovascular system MP:0005385 10.1 CHGA ACTC1 APOE VIP GFAP RECK
7 immune system MP:0005387 10.06 CRH APOE APP GFAP PLP1 MAPT
8 nervous system MP:0003631 10 CRH APOE GFAP APP ACHE PLP1
9 muscle MP:0005369 9.92 ACTC1 APOE APP ACHE GFAP PLP1
10 no phenotypic analysis MP:0003012 9.63 ACHE APP CRH APOE MAPT SST
11 normal MP:0002873 9.61 ACTC1 CRH GFAP APP MAPT SST
12 reproductive system MP:0005389 9.17 ACHE APP CHGA APOE PLP1 NOTCH3

Drugs & Therapeutics for Binswanger's Disease

Drugs for Binswanger's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
3 Analgesics Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Analgesics, Opioid Phase 4
6 Antipyretics Phase 4
7 Central Nervous System Depressants Phase 4
8 Narcotic Antagonists Phase 4
9 Narcotics Phase 4
10 Peripheral Nervous System Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo

Search NIH Clinical Center for Binswanger's Disease

Genetic Tests for Binswanger's Disease

Anatomical Context for Binswanger's Disease

MalaCards organs/tissues related to Binswanger's Disease:

39
Brain, Globus Pallidus, Smooth Muscle, Endothelial

Publications for Binswanger's Disease

Articles related to Binswanger's Disease:

(show top 50) (show all 105)
id Title Authors Year
1
Binswanger's disease: Biomarkers in the inflammatory form of vascular cognitive impairment and dementia. ( 28902409 )
2017
2
MRI features of Binswanger's disease predict prognosis and associated pathology. ( 25493272 )
2014
3
Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease. ( 24466084 )
2014
4
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. ( 25201523 )
2014
5
Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease. ( 21708443 )
2012
6
Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. ( 21239411 )
2011
7
Binswanger's disease and quantitative fractional anisotropy. ( 19547805 )
2009
8
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. ( 18617735 )
2008
9
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. ( 17403574 )
2007
10
Binswanger's disease. ( 17694788 )
2007
11
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. ( 16391479 )
2006
12
Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections. ( 15140610 )
2004
13
Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. ( 15088098 )
2004
14
From Binswanger's disease to leuokoaraiosis: what we have learned about subcortical vascular dementia. ( 15595361 )
2004
15
Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries. ( 15068169 )
2004
16
Binswanger's disease: its association with hypertension and obstructive sleep apnea. ( 12858817 )
2003
17
Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study. ( 12672544 )
2003
18
Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. ( 12053125 )
2002
19
Blood pressure variability in Binswanger's disease and isolated lacunar infarction. ( 11306773 )
2001
20
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. ( 17903801 )
2001
21
Binswanger's disease: an ongoing controversy. ( 10956563 )
2000
22
Thrombin and antithrombin in Binswanger's disease. ( 11065234 )
2000
23
Vascular cell components of the medullary arteries in Binswanger's disease brains: a morphometric and immunoelectron microscopic study. ( 10926944 )
2000
24
Binswanger's disease is not a single entity. ( 11441570 )
2000
25
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
26
Cytopathological alterations and therapeutic approaches in Binswanger's disease. ( 19519655 )
1999
27
Magnetization transfer ratio in cerebral white matter lesions of Binswanger's disease. ( 10475100 )
1999
28
A study of platelet organelles and membrane glycoprotein in patients with Binswanger's disease. ( 11717951 )
1999
29
Change of tumor necrosis factor-alpha levels in patients with Binswanger's disease. ( 12899375 )
1999
30
Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome. ( 9932966 )
1999
31
Rheologic determinant changes of erythrocytes in Binswanger's disease. ( 10063717 )
1999
32
Binswanger's disease. A rare cause of dementia in elderly persons. ( 9591403 )
1998
33
Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. ( 9452825 )
1998
34
Alterations in glia and axons in the brains of Binswanger's disease patients. ( 9227695 )
1997
35
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
36
Auditory P300, CT scans and cognitive state in Binswanger's disease. ( 9170551 )
1997
37
The apolipoprotein E gene in Binswanger's disease and vascular dementia. ( 9147873 )
1996
38
Antiphospholipid antibodies and Binswanger's disease. ( 8559413 )
1996
39
Visual and somatosensory evoked potentials in Parkinson's and Binswanger's disease. ( 8788083 )
1996
40
From UBOs to Binswanger's disease. Impact of magnetic resonance imaging on vascular dementia research. ( 8711785 )
1996
41
The role of endothelin-1 in Binswanger's disease. ( 8940785 )
1996
42
Multimodal evoked potentials in Alzheimer's disease and Binswanger's disease. ( 8679063 )
1996
43
Somatostatin, its molecular forms and monoaminergic transmitter metabolites in Binswanger's disease. Neurochemical-neuropathological considerations. ( 9117548 )
1996
44
Antiphospholipid antibodies and Binswanger's disease. ( 8559412 )
1996
45
Binswanger's disease presenting as levodopa-responsive parkinsonism: clinicopathologic study of three cases. ( 7565825 )
1995
46
Binswanger's disease--revisited. ( 7723946 )
1995
47
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8669355 )
1995
48
Platelet activation in the cerebral circulation in different subtypes of ischemic stroke and Binswanger's disease. ( 7839397 )
1995
49
Serum alpha 1-antitrypsin and alpha 2-macroglobulin in Alzheimer's and Binswanger's disease. ( 7516751 )
1994
50
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8010178 )
1994

Variations for Binswanger's Disease

Expression for Binswanger's Disease

Search GEO for disease gene expression data for Binswanger's Disease.

Pathways for Binswanger's Disease

Pathways related to Binswanger's Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.68 APOE APP GFAP MAPT NOTCH3 SYP
2 11.34 APOE APP MAPT
3 10.79 APOE APP MAPT

GO Terms for Binswanger's Disease

Cellular components related to Binswanger's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 ACHE ACTC1 APOE APP CHGA CRH
2 neuronal cell body GO:0043025 9.67 APOE CRH MAPT SST
3 extracellular region GO:0005576 9.28 ACHE APOE APP CHGA CRH NOTCH3
4 cell body GO:0044297 9.26 ACTC1 MAPT
5 neuromuscular junction GO:0031594 9.13 ACHE APP SYP
6 astrocyte projection GO:0097449 8.85 APP

Biological processes related to Binswanger's Disease according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.78 ACTC1 APP CRH PLP1
2 artery morphogenesis GO:0048844 9.52 APOE NOTCH3
3 regulation of neuronal synaptic plasticity GO:0048168 9.49 APOE SYP
4 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 9.43 APP CRH
5 amyloid precursor protein metabolic process GO:0042982 9.32 ACHE APOE
6 amyloid fibril formation GO:1990000 9.26 APP MAPT
7 regulation of long-term neuronal synaptic plasticity GO:0048169 9.21 SYP
8 astrocyte development GO:0014002 9.16 PLP1
9 locomotory exploration behavior GO:0035641 9.1 CRH
10 axon development GO:0061564 9.07 PLP1
11 neuron projection regeneration GO:0031102 8.85 APOE
12 astrocyte activation GO:0048143 8.65 MAPT
13 hormone-mediated apoptotic signaling pathway GO:0008628 8.62 CRH SST

Molecular functions related to Binswanger's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 APOE APP GFAP MAPT SYP
2 hormone activity GO:0005179 9.13 CRH SST VIP
3 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Binswanger's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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