MCID: BNS003
MIFTS: 43

Binswanger's Disease

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Binswanger's Disease

MalaCards integrated aliases for Binswanger's Disease:

Name: Binswanger's Disease 49 50
Multi-Infarct Dementia 49 69
Dementia Multi-Infarct 49 51
Binswanger Disease 51 69
Dementia - Multi-Infarct 50

Classifications:



External Ids:

UMLS 69 C0270786

Summaries for Binswanger's Disease

NINDS : 50 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Binswanger's Disease, also known as multi-infarct dementia, is related to subcortical arteriosclerotic encephalopathy and vascular dementia. An important gene associated with Binswanger's Disease is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Acetaminophen and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, globus pallidus and smooth muscle, and related phenotypes are behavior/neurological and growth/size/body region

NIH Rare Diseases : 49 Binswanger's disease is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. Most affected people experience progressive memory loss and deterioration of intellectual abilities (dementia); urinary urgency or incontinence; and an abnormally slow, unsteady gait (style of walking). While there is no cure, the progression of Binswanger's disease can be slowed with healthy lifestyle choices. Treatment is based on the signs and symptoms present in each person. Last updated: 10/8/2015

Related Diseases for Binswanger's Disease

Diseases related to Binswanger's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 subcortical arteriosclerotic encephalopathy 32.5 GFAP VIP
2 vascular dementia 31.6 ACHE APOE APP MAPT NOTCH3
3 hydrocephalus, normal-pressure 29.4 APOE MAPT
4 cerebral amyloid angiopathy, cst3-related 29.2 APOE APP MAPT
5 hydrocephalus 28.6 APOE APP GFAP MAPT SYP
6 dementia 28.4 ACHE APOE APP MAPT NOTCH3
7 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 11.7
8 ureter small cell carcinoma 10.6 CHGA SYP
9 esophageal neuroendocrine tumor 10.6 CHGA SYP
10 urinary bladder small cell neuroendocrine carcinoma 10.6 CHGA SYP
11 ovarian large-cell neuroendocrine carcinoma 10.6 CHGA SYP
12 auditory system cancer 10.6 CHGA SYP
13 acinar cell cystadenocarcinoma 10.6 CHGA SYP
14 peritoneal serous adenocarcinoma 10.6 CHGA SYP
15 gallbladder small cell carcinoma 10.6 CHGA SYP
16 primary hepatic neuroendocrine carcinoma 10.6 CHGA SYP
17 small cell carcinoma of the bladder 10.6 CHGA SYP
18 malignant glandular tumor of peripheral nerve sheath 10.6 SST SYP
19 gastrointestinal neuroendocrine tumor 10.6 CHGA SYP
20 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA SYP
21 atypical follicular adenoma 10.5 CHGA SYP
22 pancreatic somatostatinoma 10.5 SST SYP
23 pancreatic endocrine carcinoma 10.5 SST SYP
24 olfactory nerve neoplasm 10.5 CHGA SYP
25 gastrointestinal neuroendocrine benign tumor 10.5 CHGA SST
26 pancreatic serous cystadenoma 10.5 CHGA SYP
27 gastric neuroendocrine neoplasm 10.5 CHGA SST
28 cauda equina neoplasm 10.5 CHGA SYP
29 conventional angiosarcoma 10.5 CHGA SYP
30 desmoplastic infantile ganglioglioma 10.5 GFAP SYP
31 extraventricular neurocytoma 10.5 GFAP SYP
32 myofibromatosis, infantile, 1 10.5 ACTC1 NOTCH3
33 lung combined type small cell carcinoma 10.5 GFAP SYP
34 anaplastic ganglioglioma 10.5 ACTC1 GFAP
35 rhabdoid meningioma 10.5 GFAP SYP
36 glycogen-rich clear cell breast carcinoma 10.5 ACTC1 SYP
37 pilomyxoid astrocytoma 10.5 GFAP SYP
38 cutaneous leiomyosarcoma 10.5 ACTC1 GFAP
39 central nervous system primitive neuroectodermal neoplasm 10.5 GFAP SYP
40 subependymal glioma 10.5 GFAP SYP
41 chiari malformation 10.5 GFAP SYP
42 pulmonary sclerosing hemangioma 10.5 CHGA SYP
43 hyperinsulinemic hypoglycemia, familial, 2 10.5 CHGA SST
44 parachordoma 10.5 ACTC1 GFAP
45 dysembryoplastic neuroepithelial tumor 10.5 GFAP SYP
46 gastric squamous cell carcinoma 10.5 CHGA SYP
47 cerebral neuroblastoma 10.5 GFAP SYP
48 gastric small cell carcinoma 10.5 CHGA SYP
49 benign ependymoma 10.4 GFAP SYP
50 syringocystadenoma papilliferum 10.4 ACTC1 GFAP

Graphical network of the top 20 diseases related to Binswanger's Disease:



Diseases related to Binswanger's Disease

Symptoms & Phenotypes for Binswanger's Disease

MGI Mouse Phenotypes related to Binswanger's Disease:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 PLP1 MAPT SST NOTCH3 SYP VIP
2 growth/size/body region MP:0005378 10.23 PLP1 MAPT RECK SST NOTCH3 ACHE
3 homeostasis/metabolism MP:0005376 10.21 PLP1 MAPT SST NOTCH3 VIP APP
4 cardiovascular system MP:0005385 10.15 VIP GFAP RECK MAPT NOTCH3 APP
5 mortality/aging MP:0010768 10.15 VIP GFAP PLP1 RECK MAPT SST
6 cellular MP:0005384 10.13 GFAP PLP1 RECK MAPT NOTCH3 APP
7 immune system MP:0005387 10.06 VIP GFAP PLP1 MAPT SST NOTCH3
8 nervous system MP:0003631 10 PLP1 MAPT RECK SST NOTCH3 SYP
9 muscle MP:0005369 9.92 GFAP PLP1 MAPT NOTCH3 APP ACHE
10 no phenotypic analysis MP:0003012 9.7 MAPT SST APP ACHE CHGA CRH
11 normal MP:0002873 9.61 GFAP MAPT SST NOTCH3 SYP VIP
12 reproductive system MP:0005389 9.17 VIP PLP1 NOTCH3 ACHE APP CHGA

Drugs & Therapeutics for Binswanger's Disease

Drugs for Binswanger's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
3 Analgesics Phase 4
4 Central Nervous System Depressants Phase 4
5 Narcotic Antagonists Phase 4
6 Narcotics Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics, Opioid Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 3
10 Antipyretics Phase 4
11
Losartan Approved Phase 3 114798-26-4 3961
12
Amlodipine Approved Phase 3 88150-42-9 2162
13
Atenolol Approved Phase 3 29122-68-7 2249
14
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
15 Neurotransmitter Agents Phase 3,Phase 2
16 calcium channel blockers Phase 3
17 Adrenergic Agents Phase 3
18 Adrenergic Antagonists Phase 3
19 Adrenergic beta-1 Receptor Antagonists Phase 3
20 Adrenergic beta-Antagonists Phase 3
21 Sympatholytics Phase 3
22 Vasodilator Agents Phase 3
23 Angiotensin II Type 1 Receptor Blockers Phase 3
24 Angiotensin Receptor Antagonists Phase 3
25 Angiotensinogen Phase 3
26 Anti-Arrhythmia Agents Phase 3
27 Antihypertensive Agents Phase 3
28 Autonomic Agents Phase 3
29 Calcium, Dietary Phase 3
30
Donepezil Approved Phase 2 120014-06-4 3152
31 Dabigatran Phase 2
32
protease inhibitors Phase 2
33 Serine Proteinase Inhibitors Phase 2
34 HIV Protease Inhibitors Phase 2
35 Anticoagulants Phase 2
36 Antithrombin III Phase 2
37 Antithrombins Phase 2
38 Cholinergic Agents Phase 2
39 Cholinesterase Inhibitors Phase 2
40 Nootropic Agents Phase 2
41 serine Nutraceutical Phase 2

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo
2 Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function Recruiting NCT03082014 Phase 3 Amlodipine;Losartan;Atenolol
3 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
4 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
5 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
6 Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies Unknown status NCT02196532
7 Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Completed NCT01114815
8 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
9 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
10 Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis Completed NCT01928212
11 CADASIL Disease Discovery Recruiting NCT02821780
12 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Enrolling by invitation NCT02032225

Search NIH Clinical Center for Binswanger's Disease

Genetic Tests for Binswanger's Disease

Anatomical Context for Binswanger's Disease

MalaCards organs/tissues related to Binswanger's Disease:

38
Brain, Globus Pallidus, Smooth Muscle, Endothelial

Publications for Binswanger's Disease

Articles related to Binswanger's Disease:

(show top 50) (show all 106)
# Title Authors Year
1
Binswanger's disease: Biomarkers in the inflammatory form of vascular cognitive impairment and dementia. ( 28902409 )
2017
2
Binswanger's disease: toward a diagnosis agreement and therapeutic approach. ( 25201523 )
2014
3
Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease. ( 24466084 )
2014
4
MRI features of Binswanger's disease predict prognosis and associated pathology. ( 25493272 )
2014
5
Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease. ( 21708443 )
2012
6
Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. ( 21239411 )
2011
7
Binswanger's disease and quantitative fractional anisotropy. ( 19547805 )
2009
8
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. ( 18617735 )
2008
9
The corpus callosum in Binswanger's disease: A quantitative fractional anisotropy analysis. ( 29213585 )
2008
10
Binswanger's disease. ( 17694788 )
2007
11
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. ( 17403574 )
2007
12
Small artery dementia in Japan: radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. ( 16391479 )
2006
13
Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. ( 15088098 )
2004
14
From Binswanger's disease to leuokoaraiosis: what we have learned about subcortical vascular dementia. ( 15595361 )
2004
15
Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries. ( 15068169 )
2004
16
Cerebral blood flow patterns in Binswanger's disease: a SPECT study using three-dimensional stereotactic surface projections. ( 15140610 )
2004
17
Binswanger's disease: its association with hypertension and obstructive sleep apnea. ( 12858817 )
2003
18
Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study. ( 12672544 )
2003
19
Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. ( 12053125 )
2002
20
Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. ( 17903801 )
2001
21
Blood pressure variability in Binswanger's disease and isolated lacunar infarction. ( 11306773 )
2001
22
Binswanger's disease: an ongoing controversy. ( 10956563 )
2000
23
Vascular cell components of the medullary arteries in Binswanger's disease brains: a morphometric and immunoelectron microscopic study. ( 10926944 )
2000
24
Binswanger's disease is not a single entity. ( 11441570 )
2000
25
Thrombin and antithrombin in Binswanger's disease. ( 11065234 )
2000
26
Change of tumor necrosis factor-alpha levels in patients with Binswanger's disease. ( 12899375 )
1999
27
Rheologic determinant changes of erythrocytes in Binswanger's disease. ( 10063717 )
1999
28
Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome. ( 9932966 )
1999
29
Cytopathological alterations and therapeutic approaches in Binswanger's disease. ( 19519655 )
1999
30
Magnetization transfer ratio in cerebral white matter lesions of Binswanger's disease. ( 10475100 )
1999
31
A study of platelet organelles and membrane glycoprotein in patients with Binswanger's disease. ( 11717951 )
1999
32
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
33
Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. ( 9452825 )
1998
34
Binswanger's disease. A rare cause of dementia in elderly persons. ( 9591403 )
1998
35
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
36
Alterations in glia and axons in the brains of Binswanger's disease patients. ( 9227695 )
1997
37
Auditory P300, CT scans and cognitive state in Binswanger's disease. ( 9170551 )
1997
38
The apolipoprotein E gene in Binswanger's disease and vascular dementia. ( 9147873 )
1996
39
From UBOs to Binswanger's disease. Impact of magnetic resonance imaging on vascular dementia research. ( 8711785 )
1996
40
The role of endothelin-1 in Binswanger's disease. ( 8940785 )
1996
41
Antiphospholipid antibodies and Binswanger's disease. ( 8559413 )
1996
42
Somatostatin, its molecular forms and monoaminergic transmitter metabolites in Binswanger's disease. Neurochemical-neuropathological considerations. ( 9117548 )
1996
43
Multimodal evoked potentials in Alzheimer's disease and Binswanger's disease. ( 8679063 )
1996
44
Visual and somatosensory evoked potentials in Parkinson's and Binswanger's disease. ( 8788083 )
1996
45
Antiphospholipid antibodies and Binswanger's disease. ( 8559412 )
1996
46
Binswanger's disease--revisited. ( 7723946 )
1995
47
Binswanger's disease presenting as levodopa-responsive parkinsonism: clinicopathologic study of three cases. ( 7565825 )
1995
48
Platelet activation in the cerebral circulation in different subtypes of ischemic stroke and Binswanger's disease. ( 7839397 )
1995
49
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8669355 )
1995
50
Review: Binswanger's disease, leukoaraiosis and dementia. ( 8010178 )
1994

Variations for Binswanger's Disease

Expression for Binswanger's Disease

Search GEO for disease gene expression data for Binswanger's Disease.

Pathways for Binswanger's Disease

Pathways related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 APOE APP GFAP MAPT NOTCH3 SYP
2 11.34 APOE APP MAPT
3 10.79 APOE APP MAPT

GO Terms for Binswanger's Disease

Cellular components related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 ACHE ACTC1 APOE APP CHGA CRH
2 neuronal cell body GO:0043025 9.67 APOE CRH MAPT SST
3 cell body GO:0044297 9.33 ACTC1 GFAP MAPT
4 extracellular region GO:0005576 9.28 ACHE APOE APP CHGA CRH NOTCH3
5 astrocyte projection GO:0097449 9.26 APP GFAP
6 neuromuscular junction GO:0031594 9.13 ACHE APP SYP

Biological processes related to Binswanger's Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.81 ACTC1 APP CRH PLP1
2 artery morphogenesis GO:0048844 9.55 APOE NOTCH3
3 regulation of neuronal synaptic plasticity GO:0048168 9.54 APOE SYP
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.52 APP SYP
5 astrocyte development GO:0014002 9.49 GFAP PLP1
6 regulation of NMDA receptor activity GO:2000310 9.48 APP CRH
7 axon development GO:0061564 9.46 GFAP PLP1
8 locomotory exploration behavior GO:0035641 9.43 APOE CRH
9 amyloid precursor protein metabolic process GO:0042982 9.4 ACHE APOE
10 amyloid fibril formation GO:1990000 9.37 APP MAPT
11 astrocyte activation GO:0048143 9.32 APP MAPT
12 negative regulation of long-term synaptic potentiation GO:1900272 9.26 APOE APP
13 neuron projection regeneration GO:0031102 9.16 APOE GFAP
14 hormone-mediated apoptotic signaling pathway GO:0008628 8.96 CRH SST
15 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Molecular functions related to Binswanger's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 APOE APP GFAP MAPT NOTCH3 SYP
2 hormone activity GO:0005179 9.33 CRH SST VIP
3 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Binswanger's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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