MCID: BPH002
MIFTS: 35

Biphasic Synovial Sarcoma malady

Cancer diseases category

Summaries for Biphasic Synovial Sarcoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Biphasic Synovial Sarcoma, also known as synovial sarcoma, biphasic, is related to sarcoma and synovial sarcoma. An important gene associated with Biphasic Synovial Sarcoma is MUC1 (mucin 1, cell surface associated), and among its related pathways is Development EGFR signaling pathway. The compounds dihydrotestosterone and eosin have been mentioned in the context of this disorder. Affiliated tissues include small intestine and testis.

Aliases & Classifications for Biphasic Synovial Sarcoma

About this section
Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

biphasic synovial sarcoma 8
synovial sarcoma, biphasic 8 60
biphasic sarcoma of synovium 8


External Ids:

Disease Ontology8 DOID:5492
SNOMED-CT56 18588008
NCIt39 C4279

Related Diseases for Biphasic Synovial Sarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Biphasic Synovial Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.5VIM, CTAG1B, SSX2, SS18, MAGEA1, MUC1
2synovial sarcoma31.5VIM, CTAG1B, SSX2, SS18, MAGEA1, MUC1
3spindle cell sarcoma30.7VIM, MUC1
4monophasic synovial sarcoma10.5
5spindle cell synovial sarcoma10.5
6pharyngitis10.2
7small cell sarcoma10.2
8cervicitis10.2
9mediastinitis10.2
10neuroendocrine tumor10.2
11peritonitis10.2
12small intestinal sarcoma10.2
13testis sarcoma10.2
14cystadenoma10.0PAEP
15liver cirrhosis10.0MAGEA1
16hepatitis10.0MAGEA1
17endometriosis10.0PAEP
18thymus cancer10.0MUC1
19cystadenocarcinoma10.0MUC1
20infertility10.0PAEP
21rhabdomyosarcoma10.0VIM
22liposarcoma10.0VIM
23hidradenoma10.0MUC1
24angiomyolipoma10.0VIM
25fibrosarcoma10.0VIM
26syringoma10.0MUC1
27wilms tumor10.0VIM
28adenomatoid tumor10.0VIM
29seminoma10.0MAGEA1, SSX2
30gastrointestinal stromal tumor10.0VIM
31sertoli-leydig cell tumor10.0MUC1
32ocular melanoma10.0MAGEA1
33glomus tumor10.0VIM
34kidney hemangiopericytoma10.0SS18, SSX2
35laryngeal benign neoplasm10.0BCL2
36ductal carcinoma in situ10.0CDH1
37retinoblastoma10.0BCL2
38esophageal cancer10.0CDH1
39leiomyoma10.0VIM, PAEP
40familial adenomatous polyposis10.0CDH1
41hepatitis b10.0MAGEA1, CTAG1B
42stomach cancer10.0CDH1
43testicular cancer10.0MAGEA1, SSX2, CTAG1B
44leiomyosarcoma10.0MUC1, VIM
45clear cell ependymoma10.0MUC1, VIM
46mesenchymal chondrosarcoma10.0VIM, MUC1
47granular cell tumor10.0VIM
48spindle cell carcinoma10.0MUC1, VIM
49chordoma10.0MUC1, VIM
50secretory meningioma10.0MUC1, VIM

Graphical network of the top 20 diseases related to Biphasic Synovial Sarcoma:



Diseases related to biphasic synovial sarcoma

Clinical Features for Biphasic Synovial Sarcoma

About this section

Drugs & Therapeutics for Biphasic Synovial Sarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Biphasic Synovial Sarcoma

Drug clinical trials:

Search ClinicalTrials for Biphasic Synovial Sarcoma

Search NIH Clinical Center for Biphasic Synovial Sarcoma

Search CenterWatch for Biphasic Synovial Sarcoma

Genetic Tests for Biphasic Synovial Sarcoma

About this section

Anatomical Context for Biphasic Synovial Sarcoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Biphasic Synovial Sarcoma:

32
Small intestine, Testis

Animal Models for Biphasic Synovial Sarcoma or affiliated genes

About this section

Publications for Biphasic Synovial Sarcoma

About this section
Sources:
50PubMed
See all sources

Articles related to Biphasic Synovial Sarcoma:

(show all 44)
idTitleAuthorsYear
1
SS18-Bronchial Biphasic Synovial Sarcoma in an Octogenarian with Hemothorax. (24429587)
2014
2
Superficial Soft Tissue Biphasic Synovial Sarcoma With Apocrine Differentiation in the Glandular Component: A Report of Two Cases. (23563252)
2013
3
Pericardium: an exceedingly rare site for a primary biphasic synovial sarcoma. (22771650)
2012
4
Primary pulmonary biphasic synovial sarcoma: a case report and literature review. (22472156)
2012
5
Primary intrathoracic biphasic synovial sarcoma. (22519387)
2012
6
Biphasic synovial sarcoma arising from superior vena cava. (22419995)
2012
7
Biphasic synovial sarcoma in the cervical spine: Case report. (21605432)
2011
8
Biphasic synovial sarcoma of the extremity: quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation. (21516237)
2011
9
Biphasic synovial sarcoma in mandibular region. (22529590)
2011
10
Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression. (20082858)
2010
11
Primary pulmonary biphasic synovial sarcoma confirmed by molecular detection of a SYT-SSX2 fusion gene: report of 1 case. (20830232)
2010
12
Posterior mediastinal biphasic synovial sarcoma in a 12 year-old boy: a case report and review of literature. (21358103)
2010
13
Cytogenetic heterogeneity in biphasic synovial sarcoma associated with telomere instability. (20113844)
2010
14
Biphasic synovial sarcoma. (18761552)
2009
15
Biphasic synovial sarcoma of oral cavity. (18983797)
2008
16
Biphasic synovial sarcoma of the abdominal wall. (16855839)
2006
17
Biphasic synovial sarcoma of the posterior pharyngeal wall: a case report. (15971754)
2005
18
Primary intrathoracic biphasic synovial sarcoma--a case report. (16477881)
2005
19
Canine biphasic synovial sarcoma: case report and immunohistochemical characterization. (15192346)
2004
20
Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1. (14744540)
2004
21
Well-differentiated biphasic synovial sarcoma in the atlanto-occipital joint of a Holstein cow. (15557078)
2004
22
Biphasic synovial sarcoma in a 13-month-old girl. (12151720)
2002
23
MAGE antigen expression in monophasic and biphasic synovial sarcoma. (11957149)
2002
24
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. (12010367)
2002
25
Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection. (11561755)
2001
26
Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen NY-ESO-1 but not MAGE-A1 or CT7. (11668506)
2001
27
Patterns of keratin polypeptides in 110 biphasic, monophasic, and poorly differentiated synovial sarcomas. (11037348)
2000
28
Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection. (10889911)
2000
29
Pathologic quiz case. Pulmonary mass in a patient presenting with a hemothorax. Diagnosis: primary pulmonary biphasic synovial sarcoma. (10583938)
1999
30
Masked t(X;18)(p11;q11) in a biphasic synovial sarcoma revealed by FISH and RT-PCR. (9739025)
1998
31
Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. (9539323)
1998
32
Epithelial expression of glycodelin in biphasic synovial sarcomas. (9590122)
1998
33
Translocation (X;18) in a biphasic synovial sarcoma with morphologic features of neural differentiation. (9646030)
1998
34
Biphasic synovial sarcoma of the peritoneal cavity with t(X;18) demonstrated by reverse transcriptase polymerase chain reaction. (9311017)
1997
35
Primary biphasic synovial sarcoma of the pleura. (9415360)
1997
36
Intraneural biphasic synovial sarcoma: an alternative "glandular" tumor of peripheral nerve. (8832556)
1996
37
Biphasic synovial sarcoma in the small intestinal mesentery. (7539716)
1995
38
Aspiration cytology of biphasic and monophasic synovial sarcoma. A report of two cases. (7684548)
1993
39
Primary biphasic synovial sarcoma of the orbit. (1313455)
1992
40
Synovial sarcoma. Inter-relationship of the biphasic and monophasic subtypes. (1661412)
1991
41
Fine needle aspiration cytology of biphasic synovial sarcoma of soft tissue. Report of a case with ultrastructural, immunohistologic and cytophotometric studies. (2296842)
1990
42
Neuroendocrine differentiation in the glandular peripheral nerve sheath tumor. Pathologic distinction from the biphasic synovial sarcoma with glands. (2837100)
1988
43
Monophasic and biphasic synovial sarcoma. An immunohistochemical study. (2441569)
1987
44
Keratin in the epithelial-like cells of classical biphasic synovial sarcoma. (6182681)
1982

Genetic Variations for Biphasic Synovial Sarcoma

About this section

Expression for genes affiliated with Biphasic Synovial Sarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Biphasic Synovial Sarcoma

Search GEO for disease gene expression data for Biphasic Synovial Sarcoma.

Pathways for genes affiliated with Biphasic Synovial Sarcoma

About this section
Sources:
12EMD Millipore, 51QIAGEN
See all sources

Pathways related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5BCL2, CDH1, MUC1

Compounds for genes affiliated with Biphasic Synovial Sarcoma

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone44 28 11 2413.5VIM
2eosin4410.2MUC1, VIM
3s 1004410.2MUC1, VIM
4estrogen4410.2PAEP
5sialic acid4410.2PAEP
6reticulin4410.2MUC1, VIM
7mucicarmine4410.2VIM, MUC1
8exisulind4410.1BCL2, CDH1
9aristolochic acid44 211.1CDH1, VIM
10slex4410.0MUC1, CDH1
11sodium bisulfite449.9MAGEA1, CDH1
12b 723449.9VIM, MUC1, CDH1
13cytarabine44 49 1111.9VIM, MUC1, BCL2
14hematoxylin449.9CDH1, MUC1, VIM
15dexamethasone44 49 28 1112.9BCL2, CDH1
16vinblastine44 49 1111.8VIM, CDH1, BCL2
17whey449.8MUC1, PAEP
18hyaluronic acid44 2410.8VIM, MUC1, CDH1
19thymidylate449.8BCL2, CDH1, VIM
20formaldehyde44 2410.8CDH1, MUC1, VIM
21folate449.8CDH1, MUC1, VIM
22methotrexate44 49 1111.7VIM, MUC1, CDH1
23crcs449.7CDH1, MUC1
24agar449.7CDH1, MUC1, VIM
255fluorouracil449.7BCL2, CDH1, MUC1
26retinoid449.6BCL2, CDH1, VIM
27adriamycin449.6VIM, MUC1, CDH1, BCL2
28matrigel449.5VIM, MUC1, CDH1
29suberoylanilide hydroxamic acid449.5BCL2, PAEP, CDH1
30etoposide44 49 59 1112.4BCL2, CDH1, VIM
31sb 20358044 5910.4BCL2, CDH1, VIM
32progestin449.3PAEP, CDH1, MUC1, VIM
33genistein44 28 59 2 11 2414.2VIM, CDH1, PAEP, BCL2
3412-o-tetradecanoylphorbol 13-acetate449.2VIM, MUC1, CDH1
35testosterone44 59 11 2412.1PAEP, CDH1, MUC1, VIM
36paraffin449.1BCL2, CDH1, MUC1, MAGEA1, VIM
37tamoxifen44 49 28 1111.9VIM, MUC1, CDH1, PAEP, BCL2
38progesterone44 59 28 11 2412.9VIM, MUC1, CDH1, PAEP, BCL2
39vegf448.9VIM, MUC1, CDH1, PAEP, BCL2
40retinoic acid44 249.9VIM, MUC1, CDH1, PAEP, BCL2
415-aza-2deoxycytidine448.8CDH1, MAGEA1, SSX2, CTAG1B, VIM

GO Terms for genes affiliated with Biphasic Synovial Sarcoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424938.9BCL2, CDH1, SS18

Products for genes affiliated with Biphasic Synovial Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Biphasic Synovial Sarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet