MCID: BPH002
MIFTS: 39

Biphasic Synovial Sarcoma malady

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Summaries for Biphasic Synovial Sarcoma

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MalaCards based summary: Biphasic Synovial Sarcoma, also known as biphasic sarcoma of synovium, is related to synovial sarcoma and sarcoma. An important gene associated with Biphasic Synovial Sarcoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are Adhesion and EGFR Signaling Pathway. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include small intestine and testis.

Aliases & Classifications for Biphasic Synovial Sarcoma

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Biphasic Synovial Sarcoma, Aliases & Descriptions:

Name: Biphasic Synovial Sarcoma 8
Biphasic Sarcoma of Synovium 8 62
 
Synovial Sarcoma, Biphasic 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5492
SNOMED-CT57 18588008
NCIt39 C4279

Related Diseases for Biphasic Synovial Sarcoma

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Diseases related to Biphasic Synovial Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1synovial sarcoma32.2SSX2, SS18
2sarcoma30.9VIM, MUC1, SS18, SSX2, MAGEA1, CTAG1B
3hidradenoma10.4MUC1
4syringoma10.4MUC1
5cystadenocarcinoma10.4MUC1
6adenomatoid tumor10.4VIM
7paraganglioma10.4VIM
8kidney hemangiopericytoma10.3SS18, SSX2
9pharyngitis10.3
10cervicitis10.3
11mediastinitis10.3
12peritonitis10.3
13testicular cancer10.2SSX2, MAGEA1, CTAG1B
14esophageal cancer10.2CTAG1B, MAGEA1
15seminoma10.2SSX2, MAGEA1
16tubular adenocarcinoma10.2MUC1, CDH1
17clear cell ependymoma10.2VIM, MUC1
18mesenchymal chondrosarcoma10.2MUC1, VIM
19spindle cell carcinoma10.2VIM, MUC1
20spindle cell sarcoma10.2VIM, MUC1
21epithelioid sarcoma10.2VIM, MUC1
22sertoli cell tumor10.2VIM, MUC1
23dermatofibrosarcoma protuberans10.2VIM, MUC1
24secretory meningioma10.2VIM, MUC1
25rhabdoid tumor10.2VIM, MUC1
26perineurioma10.2VIM, MUC1
27bladder carcinoma10.2CDH1, MAGEA1
28sex cord-gonadal stromal tumor10.2MUC1, VIM
29malignant mixed mullerian tumor10.1VIM, MUC1
30neuroendocrine carcinoma10.1MUC1, CDH1
31chordoma10.1MUC1, VIM
32angiosarcoma10.1VIM, MUC1
33giant cell tumor10.1MUC1, VIM
34abrikosov's tumor10.1MUC1, VIM
35malignant peripheral nerve sheath tumor10.1MUC1, VIM
36neurofibroma10.1VIM, MUC1
37malignant fibroxanthoma10.1VIM, MUC1
38pleomorphic adenoma10.1VIM, MUC1
39ependymoma10.1MUC1, VIM
40oxyphilic adenoma10.1VIM, MUC1
41leiomyosarcoma10.1MUC1, VIM
42neurilemmoma10.1MUC1, VIM
43breast cancer, invasive ductal10.1BCL2, CDH1
44hemangiopericytoma10.0SSX2, MUC1, VIM
45reticulosarcoma10.0BCL2, MUC1
46leiomyoma10.0VIM, PAEP
47malignant mesothelioma10.0VIM, MUC1
48peripheral primitive neuroectodermal tumor10.0SS18, VIM
49papillary carcinoma10.0CDH1, MUC1
50laryngeal squamous cell carcinoma10.0BCL2, CDH1

Graphical network of the top 20 diseases related to Biphasic Synovial Sarcoma:



Diseases related to biphasic synovial sarcoma

Symptoms for Biphasic Synovial Sarcoma

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Drugs & Therapeutics for Biphasic Synovial Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Biphasic Synovial Sarcoma

Search NIH Clinical Center for Biphasic Synovial Sarcoma

Genetic Tests for Biphasic Synovial Sarcoma

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Anatomical Context for Biphasic Synovial Sarcoma

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MalaCards organs/tissues related to Biphasic Synovial Sarcoma:

32
Small intestine, Testis

Animal Models for Biphasic Synovial Sarcoma or affiliated genes

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Publications for Biphasic Synovial Sarcoma

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Articles related to Biphasic Synovial Sarcoma:

(show all 43)
idTitleAuthorsYear
1
Primary biphasic synovial sarcoma of gingiva: Report of a rare case. (24959041)
2014
2
SS18-Bronchial Biphasic Synovial Sarcoma in an Octogenarian with Hemothorax. (24429587)
2014
3
A non-joint tissue biphasic synovial sarcoma in a dog. (24447570)
2014
4
Superficial Soft Tissue Biphasic Synovial Sarcoma With Apocrine Differentiation in the Glandular Component: A Report of Two Cases. (23563252)
2013
5
Pericardium: an exceedingly rare site for a primary biphasic synovial sarcoma. (22771650)
2012
6
Primary pulmonary biphasic synovial sarcoma: a case report and literature review. (22472156)
2012
7
Primary intrathoracic biphasic synovial sarcoma. (22519387)
2012
8
Biphasic synovial sarcoma arising from superior vena cava. (22419995)
2012
9
Biphasic synovial sarcoma in the cervical spine: Case report. (21605432)
2011
10
Biphasic synovial sarcoma of the extremity: quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation. (21516237)
2011
11
Biphasic synovial sarcoma in mandibular region. (22529590)
2011
12
Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression. (20082858)
2010
13
Primary pulmonary biphasic synovial sarcoma confirmed by molecular detection of a SYT-SSX2 fusion gene: report of 1 case. (20830232)
2010
14
Posterior mediastinal biphasic synovial sarcoma in a 12 year-old boy: a case report and review of literature. (21358103)
2010
15
Cytogenetic heterogeneity in biphasic synovial sarcoma associated with telomere instability. (20113844)
2010
16
Biphasic synovial sarcoma. (18761552)
2009
17
Biphasic synovial sarcoma of oral cavity. (18983797)
2008
18
Biphasic synovial sarcoma of the abdominal wall. (16855839)
2006
19
Biphasic synovial sarcoma of the posterior pharyngeal wall: a case report. (15971754)
2005
20
Primary intrathoracic biphasic synovial sarcoma--a case report. (16477881)
2005
21
Canine biphasic synovial sarcoma: case report and immunohistochemical characterization. (15192346)
2004
22
Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1. (14744540)
2004
23
Well-differentiated biphasic synovial sarcoma in the atlanto-occipital joint of a Holstein cow. (15557078)
2004
24
Biphasic synovial sarcoma in a 13-month-old girl. (12151720)
2002
25
MAGE antigen expression in monophasic and biphasic synovial sarcoma. (11957149)
2002
26
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. (12010367)
2002
27
Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection. (11561755)
2001
28
Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen NY-ESO-1 but not MAGE-A1 or CT7. (11668506)
2001
29
Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection. (10889911)
2000
30
Pathologic quiz case. Pulmonary mass in a patient presenting with a hemothorax. Diagnosis: primary pulmonary biphasic synovial sarcoma. (10583938)
1999
31
Masked t(X;18)(p11;q11) in a biphasic synovial sarcoma revealed by FISH and RT-PCR. (9739025)
1998
32
Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. (9539323)
1998
33
Epithelial expression of glycodelin in biphasic synovial sarcomas. (9590122)
1998
34
Translocation (X;18) in a biphasic synovial sarcoma with morphologic features of neural differentiation. (9646030)
1998
35
Biphasic synovial sarcoma of the peritoneal cavity with t(X;18) demonstrated by reverse transcriptase polymerase chain reaction. (9311017)
1997
36
Primary biphasic synovial sarcoma of the pleura. (9415360)
1997
37
Intraneural biphasic synovial sarcoma: an alternative "glandular" tumor of peripheral nerve. (8832556)
1996
38
Biphasic synovial sarcoma in the small intestinal mesentery. (7539716)
1995
39
Primary biphasic synovial sarcoma of the orbit. (1313455)
1992
40
Fine needle aspiration cytology of biphasic synovial sarcoma of soft tissue. Report of a case with ultrastructural, immunohistologic and cytophotometric studies. (2296842)
1990
41
Neuroendocrine differentiation in the glandular peripheral nerve sheath tumor. Pathologic distinction from the biphasic synovial sarcoma with glands. (2837100)
1988
42
Monophasic and biphasic synovial sarcoma. An immunohistochemical study. (2441569)
1987
43
Keratin in the epithelial-like cells of classical biphasic synovial sarcoma. (6182681)
1982

Variations for Biphasic Synovial Sarcoma

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Expression for genes affiliated with Biphasic Synovial Sarcoma

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Expression patterns in normal tissues for genes affiliated with Biphasic Synovial Sarcoma

Search GEO for disease gene expression data for Biphasic Synovial Sarcoma.

Pathways for genes affiliated with Biphasic Synovial Sarcoma

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Pathways related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CDH1, MUC1
29.7CDH1, MUC1
3
Show member pathways
9.7VIM, CDH1
4
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4CDH1, BCL2, MUC1
5
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.3CDH1, BCL2, VIM
6
Show member pathways
9.0CDH1, BCL2, MUC1, VIM

Compounds for genes affiliated with Biphasic Synovial Sarcoma

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Compounds related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1eosin4410.2MUC1, VIM
2s 1004410.2MUC1, VIM
3reticulin4410.2MUC1, VIM
4mucicarmine4410.2VIM, MUC1
5exisulind4410.1CDH1, BCL2
6aristolochic acid44 211.1CDH1, VIM
7slex4410.0CDH1, MUC1
8crcs449.9MUC1, CDH1
9b 723449.8CDH1, MUC1, VIM
10cytarabine44 50 1111.8VIM, MUC1, BCL2
11hematoxylin449.8CDH1, MUC1, VIM
12indole-3-carbinol449.8BCL2, CDH1
13sodium bisulfite449.8MAGEA1, CDH1
14dihydrotestosterone44 28 24 1112.8CDH1, MUC1, VIM
15hyaluronic acid44 2410.8VIM, MUC1, CDH1
16formaldehyde44 2410.8CDH1, MUC1, VIM
17vinblastine44 50 1111.8VIM, BCL2, CDH1
18folate449.8CDH1, MUC1, VIM
19thymidylate449.8CDH1, BCL2, VIM
20methotrexate50 44 1111.7VIM, MUC1, CDH1
21agar449.7CDH1, MUC1, VIM
22sulindac44 1110.7BCL2, CDH1
235fluorouracil449.7CDH1, BCL2, MUC1
24matrigel449.7CDH1, MUC1, VIM
25whey449.7MUC1, PAEP
26retinoid449.6VIM, BCL2, CDH1
2712-o-tetradecanoylphorbol 13-acetate449.6VIM, MUC1, CDH1
28etoposide44 50 61 1112.6VIM, BCL2, CDH1
29sb 20358044 6110.6CDH1, BCL2, VIM
30paclitaxel44 50 1111.5CDH1, BCL2, VIM
31rapamycin449.5CDH1, BCL2, VIM
32adriamycin449.5VIM, MUC1, BCL2, CDH1
33butyrate449.5VIM, MUC1, BCL2, CDH1
34actinomycin d449.4BCL2, MUC1, VIM
35wortmannin449.4CDH1, BCL2, VIM
36dexamethasone44 50 28 1112.4VIM, MUC1, BCL2, CDH1
37sialic acid449.3PAEP, MUC1, CDH1
38suberoylanilide hydroxamic acid449.3PAEP, BCL2, CDH1
39doxorubicin44 50 1111.2CDH1, BCL2, VIM
40glycogen44 2410.1VIM, MUC1, CDH1
41progestin449.0PAEP, VIM, MUC1, CDH1
42testosterone44 61 24 1112.0PAEP, VIM, MUC1, CDH1
43genistein44 28 61 2 24 1113.9PAEP, VIM, BCL2, CDH1
44paraffin448.8CDH1, BCL2, MAGEA1, MUC1, VIM
45tamoxifen44 50 28 1111.7PAEP, VIM, MUC1, BCL2, CDH1
46progesterone44 28 61 24 1112.6PAEP, VIM, MUC1, BCL2, CDH1
47vegf448.6CDH1, BCL2, MUC1, VIM, PAEP
48estrogen448.6PAEP, VIM, MUC1, BCL2, CDH1
49retinoic acid44 249.6CDH1, BCL2, MUC1, VIM, PAEP
505-aza-2deoxycytidine448.6CTAG1B, CDH1, MAGEA1, SSX2, VIM

GO Terms for genes affiliated with Biphasic Synovial Sarcoma

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Biological processes related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to toxic substanceGO:0096369.7CDH1, BCL2
2cellular component disassembly involved in execution phase of apoptosisGO:0069219.4CDH1, VIM
3response to drugGO:0424939.1CDH1, BCL2, SS18

Molecular functions related to Biphasic Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.7CDH1, VIM

Products for genes affiliated with Biphasic Synovial Sarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Biphasic Synovial Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet