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MCID: BPL004

Bipolar Affective Disorder malady
21 drugs, 107 genes, 5 tissues, 332 related diseases, 17 phenotypes, 138 articles, clinical trials.

Summaries for Bipolar Affective Disorder

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MalaCards: Bipolar Affective Disorder, also known as bipolar disorder, is related to schizophrenia and major affective disorder. An important gene associated with Bipolar Affective Disorder is ALG9 (asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)), and among its related pathways are Metabolism of amino acids and derivatives and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The drugs lithium citrate and clonazepam and the compounds nicotine and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Aliases & Descriptions for Bipolar Affective Disorder

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43UMLS, 7diseasecard
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bipolar affective disorder 7
bipolar disorder 43

Related Diseases for Bipolar Affective Disorder

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13GeneCards, 14GeneDecks
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Diseases related to bipolar affective disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia36.0HTR2A, DRD3, DISC1, COMT
2major affective disorder30.8ATP2A2, HTR2A, HTR3A, TPH1, ACE, SLC6A3
3wolfram syndrome30.0DRD5, COMT, TH, WFS1
4manic-depressive illness29.5MAOA, MAOB, TPH1, DRD2, DRD3, DRD4
5alcoholism29.1MAOA, MAOB, HTR2A, HTR2C, HTR3A, TPH1
6intellectual disability28.4BDNF, CHRNA7, MAOA, GNAS, DRD4, SPAST
7schizoaffective disorder28.3BDNF, KCNN3, CHRFAM7A, CHRNA7, MAOA, HTR2A
8bipolar i disorder28.2BDNF, P2RX7, GRM3, HTR2A, ALG9, TPH2
9major depressive disorder27.8PDE4B, BDNF, CHRNA7, S100B, P2RX7, MAOA
10ppm-x syndrome27.6BDNF, MAOB, HTR2A, HTR3A, DRD2, DRD4
11panic disorder26.3PDE4B, BDNF, MAOA, IGF1, HTR2A, HTR2C
12down syndrome24.9NCAM1, BDNF, KCNN3, CHRNA7, S100B, IGF1
13twinning24.7NCAM1, BDNF, MAOA, IGF1, TNF, DRD1
14mood disorder24.6BDNF, P2RX7, ATP2A2, IMPA2, MAOA, MAOB
15homocysteine24.5CHRNA7, IGF1, TNF, DYT10, DRD2, NOS1
16seizures24.4BDNF, S100B, IMPA2, MAOA, MAOB, HTR2A
17cerebritis19.7NCAM1, BDNF, CHRNA7, S100B, MCHR2, MAOA
18neuroblastoma19.6NCAM1, BDNF, CHRNA7, S100B, P2RX7, MPP2
19bipolar disorder19.5PIP4K2A, NCAM1, PDE4B, VAMP7, BDNF, KCNN1
20cholesterol19.1VAMP2, BDNF, CHRNA7, ATP2A2, MPP2, MAOB
21alzheimer's disease16.8PIP4K2A, NCAM1, BDNF, KCNN1, CHRFAM7A, CHRNA7
22neuronitis15.6PIP4K2A, NCAM1, PDE4B, VAMP2, VAMP3, VAMP7
23delusional disorder13.8DRD3, DRD4, TH
24autoimmune polyendocrine syndrome type 113.7TPH1, DDC, TH, GAD1
25autoimmune polyendocrine syndrome13.7TPH1, DDC, TH, GAD1
26cervical dystonia13.6BDNF, DRD5, TH
27tic disorder13.6HTR2A, DRD2, DRD4
28antisocial personality disorder13.6MAOA, HTR2A, DRD2, DRD4, SLC6A4
29bulimia nervosa13.6HTR3A, COMT, SLC6A4
30anxiety-related personality traits13.6BDNF, COMT, SLC6A4
31attention deficit hyperactivity disorder13.6TPH2, DRD5, SLC6A3
32conduction disease13.6MAOA, DRD4, DRD5, DBH, SLC6A3, SLC6A4
33myoclonus-dystonia13.5DRD2, DRD3, DRD4
34movement disease13.5DRD2, DRD3, DDC, TH, SLC6A3
35mitral valve disease13.5TPH1, ACE, AGT
36alcoholic psychosis13.5HTR2A, SLC6A3, SLC6A4
37generalized anxiety disorder13.5MAOA, HTR2A, HTR2C, HTR3A, TPH1, SLC6A4
38cognitive disease13.5CHRNA7, MAOA, MAOB, COMT
39renal hypertension13.5ACE, DBH, ADM
40striatonigral degeneration13.5DRD1, DRD2, SLC6A3
41fetal akinesia syndrome x-linked13.5MAOB, COMT, GAD1
42focal dystonia13.5DRD2, DRD5, TBP
43opiate dependence13.5DRD2, DRD3, COMT, TH, ADCY10
44novelty seeking personality13.5MAOA, DRD2, DRD4, COMT, ACE
45ganglioneuroblastoma13.4S100B, CRH, TH, ADM
46postural orthostatic tachycardia syndrome13.4NOS1, AGT, DBH, ADRA2C
47personality disorder13.4MAOA, MAOB, TPH1, TPH2, DRD2, DRD3
48insomnia13.4HTR2A, HTR2C, HTR3A, CRH, SLC6A4
49myoclonus13.4HTR2A, HTR2C, DRD2, DRD3, DRD4, WFS1
50alcohol withdrawal delirium13.4TH, DBH, SLC6A3

Graphical network of the top 20 diseases related to bipolar affective disorder:



Graphical network of diseases related to bipolar affective disorder

Clinical Features for Bipolar Affective Disorder

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Drugs & Therapeutics for Bipolar Affective Disorder

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 carbamazepine, clonazepam, clozapine, divalproex, divalproex sodium, gabapentin, gabapentin enacarbil, lamotrigine, lithium, lithium (as citrate), lithium carbonate, lithium citrate, olanzapine, quetiapine, quetiapine fumarate, risperidone, tiagabine, tiagabine hydrochloride, topiramate, valproate sodium, valproic acid

Genetic Tests for Bipolar Affective Disorder

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Anatomical Context for Bipolar Affective Disorder

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MalaCards organs/tissues related to bipolar affective disorder:

22
Brain, Cortex, T cells, B lymphoblasts, B cells

Phenotypes for genes affiliated with Bipolar Affective Disorder

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25MGI
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MGI Mouse Phenotypes related to bipolar affective disorder:

25 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:00053799.1WFS1, DBH, DFNB31, TDRD9, NRG1, DRD5
2no phenotypic analysisMP:00030129.1GABRA5, ADARB1, WFS1, TDRD9, ABCG1, NR1D1
3renal/urinary system phenotypeMP:00053678.3DDC, NR3C2, ABCG1, AGT, DFNB31, ADRA1A
4reproductive system phenotypeMP:00053897.7AGT, TDRD9, DFNB31, PRL, SLC6A3, ADCY10
5adipose tissue phenotypeMP:00053757.4DRD3, NR3C1, NOS1, ABCG1, ACE, AGT
6liver/biliary system phenotypeMP:00053707.2ACE, AGT, TH, DFNB31, PRL, PRKAR2B
7normal phenotypeMP:00028737.0CRH, NOS1, HIP1R, TH, SLC6A3, SLC25A4
8integument phenotypeMP:00107716.6TH, CRH, NRG1, NR3C1, DRD2, DBH
9respiratory system phenotypeMP:00053886.4NR3C1, NRG1, CRH, NOS1, ABCG1, TH
10growth/size phenotypeMP:00053786.4TH, AGT, HIP1R, ACE, ABCG1, PLA2G6
11muscle phenotypeMP:00053696.2PLA2G6, NOS1, AGT, SLC6A3, SLC25A4, SLC6A4
12immune system phenotypeMP:00053876.0DDC, NR3C1, CRH, PLA2G6, NOS1, COMT
13nervous system phenotypeMP:00036315.8PDE4B, BRD1, VAMP3, BDNF, NRG1, CRH
14cardiovascular system phenotypeMP:00053855.3TH, AGT, ACE, COMT, NOS1, NRG1
15mortality/agingMP:00107683.8AGT, ACE, NOS1, PLA2G6, NRG1, NR3C2
16homeostasis/metabolism phenotypeMP:00053762.7DRD1, DFNB31, DBH, PRL, PRODH, PRKAR2B
17behavior/neurological phenotypeMP:00053862.4NCAM1, TNF, DTNBP1, DRD1, DRD2, DRD3

Publications for genes affiliated with Bipolar Affective Disorder

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35PubMed
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Articles related to bipolar affective disorder:

(show top 50)    (show all 138)
idTitleAuthorsYearAffiliating Genes
1A systematic association mapping on chromosome 6q in bipolar affective disorder-evidence for the melanin-concentrating-hormone-recep tor-2 gene as a risk factor for bipolar affective disorder. (19927306)Abou Jamra R.... Schumacher J.2010MCHR2
2Support of association between BRD1 and both schizoph renia and bipolar affective disorder. (19693800)Nyegaard M.... rglum A.D.2010BRD1, ZBED4
3Nuclear receptor rev-erb-{alpha} circadian gene varia nts and lithium carbonate prophylaxis in bipolar affective disorder. (20348464)Campos-de-Sousa S.... Collier D.2010NR1D1, NR1D2
4Family-based association study for bipolar affective disorder. (20414141)Secolin R.... Lopes-Cendes I.2010CAPN6, LAMP3, DFNB31
5Association between the serotonin 2A receptor gene an d bipolar affective disorder in an Australian cohort. (19584773)McAuley E.Z.... Schofield P.R.2009HTR2A
6An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. (19339916)Prata D.P.... Collier D.A.2009NRG1
7Association study between genetic variants at the VAMP2 and VAMP3 loci and bipolar affective disorder. (18628682)Abou Jamra R.... Schumacher J.2008VAMP2, DAO, VAMP3
8Hereditary spastic paraplegia, bipolar affective disorder and intellectual disability: a case report. (18337300)Whitty M.... Ramsay L.2008SPAST
9A polymorphism linked to bipolar affective disorder does not alter the CRE activity of constitutively activated trace amine receptor 4. (17895926)Reiners J.... Wernet W.2007TAAR6
10Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia. (16741940)Severinsen J.E.... Borglum A.D.2006MCHR1
11First family-based test for association of neuregulin with bipolar affective disorder. (16868568)Cassidy F.... McKeon P.2006NRG1
12No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia. (16691125)Jamra R.A.... Schumacher J.2006SLC6A5
13Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder. (16924267)Severinsen J.E.... Borglum A.D.2006BRD1
14Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. (15799788)Lai T.J.... Sun H.S.2005TPH1
15Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study. (15274036)Oswald P.... Mendlewicz J.2004BDNF
16Allelic association study between phospholipase A2 genes and bipolar affective disorder. (12895207)Meira-Lima I.... Vallada H.2003PLA2G6, PLA2G2D
17Altered CTX-catalyzed and endogenous [32P]ADP-ribosylation of stimulatory G protein alphas isoforms in postmortem bipolar affective disorder temporal cortex. (12749029)Andreopoulos S.... Warsh J.J.2003GNAS
18Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. (11857579)Massat I.... Mendlewicz J.2002DRD2, DRD3
19Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. (12431765)Bellivier F.... Leboyer M.2002SLC6A4
20A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family. (12030331)Baysal B.E.... Detera-Wadleigh S.D.2002ALG9
21Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder. (12192619)Nyegaard M.... Kruse T.A.2002SSTR5
22Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder. (11543740)Wang H.... Friedman E.2001GNB2L1, DYT10
23CAG repeats of CTG18.1 and KCNN3 in Korean patients with bipolar affective disorder. (11532529)Jin D.K.... Kim D.K.2001KCNN3
24Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder. (10893488)Evans K.L.... Porteous D.J.2000WFS1
25WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder. (10760554)Ohtsuki T.... Arinami T.2000WFS1
26Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia. (10893499)Vogt I.R.... Nothen M.M.2000HTR6
27Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. (10686549)Ho L.W.... Rubinsztein D.C.2000MAOA, DRD2, TPH1
28Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls. (10898906)Rietschel M.... Nothen M.M.2000TPH1
29A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. (10893484)Massat I.... Mendlewicz J.2000HTR2A
30Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder. (10616951)McQuillin A.... Gurling H.1999TH
31Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder. (10578236)Borglum A.D.... Kruse T.A.1999DDC
32Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients. (10221749)Wang H.Y.... Friedman E.1999DYT10
33Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter. (10402508)Furlong R.A.... Rubinsztein D.C.1999MAOA
34hSKCa3: no association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia. (10697822)Rohrmeier T.... Eichhammer P.1999KCNN3, KCNN1
35A functional variant of the serotonin transporter gene in families with bipolar affective disorder. (9543202)Ewald H.... Kruse T.A.1998SLC6A4
36Support for the possible locus on chromosome 4p16 for bipolar affective disorder. (9774780)Ewald H.... Kruse T.A.1998DRD5
37Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder. (9514592)Papadimitriou G.N.... Stefanis C.N.1998GABRA5
385-HT2A receptor and bipolar affective disorder: association studies in affected patients. (9086465)Arranz M.J.... Collier D.A.1997HTR3A
39Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder. (9341875)Gutierrez B.... Fananas L.1997HTR2A
40Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder. (9352569)Li T.... Collier D.A.1997COMT
41Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. (9399688)Kunugi H.... Nanko S.1997SLC6A4
42Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. (8823764)Gutierrez B.... Collier D.1996HTR2C
43Systematic screening for mutations in the 5'-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder. (8837716)Cichon S.... Propping P.1996DRD1
44Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees. (8561212)Smyth C.... Gurling H.1996TH
45Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. (8886289)Wang H.Y.... Friedman E.1996DYT10
46Possible association between the dopamine D3 receptor gene and bipolar affective disorder. (7573178)Parsian A.... Todd R.D.1995DRD3
47Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. (7848049)Manji H.K.... Belmaker R.H.1995ADCY10
48Association analysis of the monoamine oxidase A gene in bipolar affective disorder by using family-based internal controls. (7573065)Nothen M.M.... Franzek E.1995MAOA
49Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. (7485270)Lim L.C.... Gill M.1995MAOA, MAOB
50No evidence of association between dopamine D4 receptor variants and bipolar affective disorder. (7810585)Lim L.C.... Gill M.1994DRD4

Expression for genes affiliated with Bipolar Affective Disorder

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Bipolar Affective Disorder

Pathways for genes affiliated with Bipolar Affective Disorder

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38Reactome, 34PharmGKB, 20KEGG, 41Thomson Reuters, 10EMD Millipore, 36QIAGEN, 3Cell Signaling Technology
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Pathways related to bipolar affective disorder according to GeneDecks:

(show all 21)
idPathwayScoreTop Affiliating Genes
1Metabolism of amino acids and derivatives3810.4PRODH, DBH, TH, DAO, DDC, TPH2
2Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics3410.2TH, DDC, DRD4, DRD3, DRD2, DRD1
3Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics3410.2SLC6A4, DDC, TPH2, TPH1, GNAS, HTR6
4Tryptophan metabolism2010.2DDC, TPH2, TPH1, MAOB, MAOA
5Sympathetic Nerve Pathway (Neuroeffector Junction)3410.1ADM, ADRA1A, ADRA2C, DBH, TH, DDC
6Tyrosine metabolism p.1 (dopamine)4110.1DBH, TH, COMT, DDC, MAOB, MAOA
7Tyrosine metabolism p.1 (dopamine)1010.1DBH, MAOA, MAOB, DDC, COMT, TH
8Tyrosine metabolism2010.1DBH, TH, COMT, DDC, MAOB, MAOA
9Transcription_CREB pathway4110.1HTR6, DRD1
10Transcription CREB pathway109.9PRKAR2B, GNAS, HTR7, HTR6
11CDK5 Pathway369.9DRD5, DRD4, DRD3, DRD2, DRD1, BDNF
12Development_Ligand-independent activation of ESR1 and ESR2419.8PRKAR2B, DRD5, DRD1, GNAS, HTR7, HTR6
13Amine ligand-binding receptors389.8DRD3, DRD2, DRD1, HTR7, HTR6, HTR2C
14Development Ligand-independent activation of ESR1 and ESR2109.7PRKAR2B, NRG1, DRD5, DRD1, GNAS, HTR7
15Arginine and proline metabolism209.3MAOA, MAOB, DAO, NOS1, PRODH
16Dopamine-DARPP32 Feedback onto cAMP Pathway369.2PRKAR2B, NOS1, DRD5, DRD4, DRD3, DRD2
17Long-term depression209.0NOS1, PLA2G2D, PLA2G6, CRH, GNAS, IGF1
18Neuroscience38.8GAD1, WFS1, DBH, TH, NOS1, DDC
19Intracellular Calcium Signaling368.7NRG1, TRPM2, HTR7, HTR6, HTR3A, HTR2C
20Calcium signaling pathway208.6DRD1, DRD5, NOS1, SLC25A4, ADRA1A, GNAS
21Neuroactive ligand-receptor interaction208.5GABRA5, ADORA1, ADRA1A, HTR6, HTR2C, HTR2A

Compounds for genes affiliated with Bipolar Affective Disorder

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to bipolar affective disorder according to GeneDecks:

(show top 50)    (show all 302)
idCompoundScoreTop Affiliating Genes
1nicotine32 34 9 9 13.1CRH, NR3C2
2methylphenidate32 9 9 11.9TH, COMT, DRD5, DRD4, DRD2, DRD1
3ropinirole32 9 9 11.7MAOB, ADRA2C, COMT, DRD5, DRD4, DRD3
46-hydroxydopamine32 9.7SLC6A3, BDNF, MAOA, DBH, TH, COMT
5carbidopa32 9.7SLC6A3, DBH, PRL, MAOB, TPH1, DDC
6lisuride32 9 9 11.7PRL, DRD5, DRD4, DRD3, DRD2, HTR2A
7Methotrimeprazine9 9 10.6ADRA1A, ADRA2C, DRD5, DRD4, DRD3, DRD2
8homovanillic acid32 18 10.6PRL, DBH, TH, COMT, CRH, DDC
9mhpg32 9.6PRL, DBH, TH, COMT, CRH, DDC
10pergolide32 9 9 11.5ADRA1A, HTR2A, ADRA2C, PRL, COMT, DRD5
11paliperidone32 9 9 11.5ADRA2C, DRD1, HTR2C, HTR2A, DRD3, DRD4
12ziprasidone32 9 9 11.4PRL, HTR2A, DRD5, DRD4, DRD3, DRD2
13maoa32 9.4SLC6A4, SLC6A3, DBH, BDNF, MAOA, TH
14aripiprazole32 34 9 18 9 13.4PRL, DRD5, DRD4, DRD3, DRD2, DRD1
15bromocriptine32 9 9 11.4ADRA1A, ADCY10, PRL, DDC, DRD5, DRD3
16mdma32 9.3TH, PRL, SLC6A3, SLC6A4, MAOA, MAOB
17pramipexole32 9 9 11.3ADRA2C, SLC6A3, PRL, TH, COMT, DRD5
18citalopram32 34 9 18 9 13.2BDNF, HTR2C, HTR3A, MAOA, CRH, PRL
19cabergoline32 9 9 11.2COMT, DRD5, DRD4, DRD3, DRD2, DRD1
20apomorphine32 9 9 11.1ADCYAP1, ADRA2C, MAOB, HTR2A, HTR2C, DRD1
21risperidone32 34 9 18 9 13.1DRD2, DRD1, HTR6, HTR3A, HTR2C, HTR2A
22opiate32 9.1ADCY10, SLC6A4, SLC6A3, ADORA1, DRD2, DRD1
23quetiapine32 9 18 9 12.1DRD3, DRD2, DRD1, HTR7, HTR6, HTR3A
24epinephrine32 9 18 9 12.0BDNF, MAOB, DRD2, DRD4, DDC, CRH
25choline32 9 18 9 12.0CHRNA7, S100B, P2RX7, MAOB, GAD1, NOS1
26methamphetamine32 9 9 11.0DRD3, DRD2, DRD1, TPH1, MAOB, MAOA
27olanzapine32 34 9 18 9 12.9ADRA1A, ADRA2C, HTR2A, BDNF, HTR2C, HTR3A
28gnrh32 8.9NCAM1, IGF1, HTR2C, GNAS, NRG1, CRH
29levodopa32 9 9 10.6BDNF, MAOA, MAOB, IGF1, TPH1, DDC
30haloperidol32 34 9 9 11.5MAOB, MCHR1, BDNF, HTR2A, HTR3A, DRD1
31catecholamine32 8.5BDNF, ADM, DDC, DRD5, DRD4, DRD3
32imipramine32 34 9 18 9 12.5NR3C1, DRD3, DRD1, HTR3A, HTR2A, MAOB
33mptp32 8.5GAD1, MAOA, CHRNA7, BDNF, MAOB, DRD1
34fluoxetine32 34 9 9 11.3TPH2, TPH1, GNAS, HTR3A, HTR2C, HTR2A
35clozapine32 34 9 9 11.2GAD1, HTR3A, HTR2C, HTR2A, CHRNA7, HTR6
36corticosterone32 18 8.9ADCYAP1, ADM, CRH, NR3C2, NR3C1, BDNF
37cocaine32 9 9 9.6DBH, TH, COMT, NOS1, PLA2G6, CRH
38cyclic amp32 18 8.5ADCYAP1, ADORA1, ADCY10, PRKAR2B, OR4D2, NRG1
395-hydroxytryptamine32 7.3ADCYAP1, ADORA1, ADCY10, SLC6A4, SLC6A3, PRL
40potassium32 9 18 9 9.8GAD1, DPP10, AGT, ACE, NISCH, NRG1
41adenylate32 6.7BDNF, DRD1, DRD2, HTR7, HTR3A, HTR2C
42calcium32 9 18 9 9.6TPH1, DRD1, DRD3, DRD4, DAO, SSTR5
43histamine32 18 7.6MAOA, PLA2G6, NOS1, ADORA1, CRH, DDC
44acetylcholine32 9 18 9 9.4GAD1, ADCYAP1, ADM, ADORA1, ADCY10, SLC6A3
45gaba32 42 7.2NCAM1, GABRA5, GAD1, ADCYAP1, ADORA1, SLC6A5
46nmda32 42 7.2DYT10, DRD1, DRD2, DRD3, DAO, DAOA
47norepinephrine32 9 18 9 8.4ACE, NISCH, COMT, NOS1, CRH, NR3C2
48glutamate32 5.3PRODH, ADCY10, ADORA1, ADARB1, ADCYAP1, GAD1
49serine32 4.9ADCYAP1, CRH, NCAM1, VAMP2, TBP, DAO
50dopamine32 9 18 9 6.7DRD1, DRD2, DRD3, DRD4, DRD5, DISC1

GO Terms for genes affiliated with Bipolar Affective Disorder

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12Gene Ontology
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Cellular components related to bipolar affective disorder according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:04300510.2TH, DTNBP1, TPH2, TPH1, VAMP7, VAMP3
2postsynaptic densityGO:0140699.7NR3C1, DISC1, DRD2, DTNBP1, GRM3, ADORA1
3postsynaptic membraneGO:0452119.3GABRA5, ADORA1, DISC1, DTNBP1, HTR3A, GRM3
4axonGO:0304249.3ADCY10, ADRA2C, SLC6A3, DFNB31, DDC, DRD2
5neuronal cell bodyGO:0430259.2DFNB31, DBH, SLC6A3, ADCY10, ADORA1, DDC
6perinuclear region of cytoplasmGO:0484718.7SPAST, NOS1, HIP1R, PRKAR2B, ADCY10, DAOA
7integral to plasma membraneGO:0058877.5GABRA5, DRD3, DRD4, DRD5, SSTR5, NRG1
8plasma membraneGO:0058865.1THSD7A, ACE, ABCG1, NISCH, COMT, SSTR5

Biological processes related to bipolar affective disorder according to GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1serotonin biosynthetic processGO:04242710.8DDC, TPH2, TPH1
2indolalkylamine biosynthetic processGO:04621910.7DDC, TPH2, TPH1
3response to histamineGO:03477610.6DRD4, DRD3, DRD2
4phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD5, DRD2, DRD1
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2, DRD1
6catecholamine biosynthetic processGO:04242310.6DBH, TH, DDC
7adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD4, DRD3, DRD2
8behavioral response to ethanolGO:04814910.6DBH, DRD4, DRD2
9behavioral response to cocaineGO:04814810.6DRD4, DRD3, DRD2, DRD1
10dopamine metabolic processGO:04241710.6DRD4, DRD3, DRD2, DRD1
11dopamine biosynthetic processGO:04241610.5SLC6A3, DDC, TH
12visual learningGO:00854210.5DBH, DRD5, DRD3, DRD2, DRD1
13dopamine catabolic processGO:04242010.5SLC6A3, DBH, COMT, MAOA
14fear responseGO:04259610.5DBH, DRD4, BDNF
15prepulse inhibitionGO:06013410.5SLC6A3, DRD3, DRD2, DRD1
16adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5GNAS, DRD1, DRD3, DRD5
17response to cocaineGO:04222010.5SLC6A3, DRD5, DRD3, DRD2, HTR3A
18circadian rhythmGO:00762310.5SLC6A4, NR3C1, NR1D1, DDC, TPH2, HTR7
19regulation of dopamine metabolic processGO:04205310.5DRD1, DRD4, SLC6A3
20response to amphetamineGO:00197510.4DBH, DRD5, DRD4, DRD3, DRD2, DRD1
21cellular response to catecholamine stimulusGO:07187010.4DRD5, DRD1, GNAS
22negative regulation of blood pressureGO:04577610.4ADORA1, DRD5, DRD3, DRD2
23regulation of long-term neuronal synaptic plasticityGO:04816910.4AGT, DRD5, DRD2, DRD1
24temperature homeostasisGO:00165910.3ADORA1, DRD2, DRD1, HTR2A
25synaptic transmission, dopaminergicGO:00196310.3TH, CRH, DRD5, DRD4, DRD3, DRD2
26peristalsisGO:03043210.3DRD1, DRD2, AGT
27negative regulation of adenylate cyclase activityGO:00719410.3DRD4, DRD3, DRD2, GRM3
28arachidonic acid secretionGO:05048210.3ACE, DRD4, DRD3, DRD2
29negative regulation of synaptic transmission, glutamatergicGO:05196710.3ADORA1, DRD2, HTR2A
30regulation of dopamine secretionGO:01405910.3HTR2A, DRD2, DRD3
31feeding behaviorGO:00763110.3CRH, DRD2, HTR2C, MCHR1, BDNF
32serotonin receptor signaling pathwayGO:00721010.2HTR2A, HTR2C, HTR3A
33learningGO:00761210.2PRKAR2B, TH, COMT, DRD3
34social behaviorGO:03517610.2SLC6A4, DBH, DRD4, DRD3
35release of sequestered calcium ion into cytosolGO:05120910.2P2RX7, HTR2A, HTR2C, DRD2
36activation of adenylate cyclase activityGO:00719010.2ADCYAP1, DRD5, DRD1, GNAS
37memoryGO:00761310.2SLC6A4, DBH, TH, DRD1, HTR2A, S100B
38negative regulation of protein secretionGO:05070910.1DRD3, DRD2, DRD4
39locomotory behaviorGO:00762610.0SLC6A3, DBH, TH, NRG1, DRD3, DRD2
40learning or memoryGO:00761110.0CRH, DRD3, S100B, BDNF
41regulation of insulin secretionGO:0507969.9ADRA2C, SLC25A4, PRKAR2B, SSTR5, TNF, GNAS
42G-protein coupled receptor internalizationGO:0020319.9ADM, DRD3, DRD2
43cell-cell signalingGO:0072679.9ADCYAP1, ADM, ADORA1, ADRA1A, ADRA2C, AGT
44agingGO:0075689.8ADM, ADRA1A, SLC6A3, AGT, NR3C1, HTR2A
45female pregnancyGO:0075659.8ADCYAP1, ADM, PRL, COMT, CRH, GNAS
46neurotransmitter biosynthetic processGO:0421369.5GAD1, SLC6A3, TH, COMT, NOS1, MAOA
47small molecule metabolic processGO:0442819.2COMT, ABCG1, AGT, TH, DBH, PRODH
48response to hypoxiaGO:0016668.9ADM, ADORA1, SLC6A4, TH, NOS1, DRD2
49synaptic transmissionGO:0072688.9VAMP2, DRD5, CRH, COMT, DBH, SLC6A3
50response to drugGO:0424938.7DRD3, COMT, SLC6A3, SLC6A4, ADRA1A, GAD1

Molecular functions related to bipolar affective disorder according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine receptor activityGO:00495210.2DRD5, DRD4, DRD1
2dopamine receptor activity, coupled via Gi/GoGO:00159110.1DRD4, DRD3, DRD2
3dopamine bindingGO:03524010.1DRD1, SLC6A3, DRD5, DRD4, DRD3, DRD2
4serotonin bindingGO:05137810.0HTR3A, HTR2C, HTR2A, MAOA
5serotonin receptor activityGO:0049939.6HTR7, HTR3A, HTR2C, HTR2A
6drug bindingGO:0081449.4SLC6A3, ACE, DRD5, DRD4, DRD3, DRD2
7receptor bindingGO:0051029.1ADM, SLC6A3, CRH, NRG1, DAO, TRDN

Sources for Bipolar Affective Disorder

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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