MCID: BPL003
MIFTS: 75

Bipolar Disorder malady

Genetic diseases, Rare diseases, Mental diseases categories
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Summaries for Bipolar Disorder

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards: Bipolar Disorder, also known as manic depression, is related to schizophrenia and major depressive disorder. An important gene associated with Bipolar Disorder is ALG9 (ALG9, alpha-1,2-mannosyltransferase), and among its related pathways are SIDS Susceptibility Pathways and Development EGFR signaling pathway. The drugs carbamazepine and clonazepam and the compounds carbidopa and mdma have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related mouse phenotypes are taste/olfaction and muscle.

Disease Ontology:8 A mood disorder that involves alternating periods of mania and depression.

NIH Rare Diseases:43 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia:65 Bipolar disorder, also known as bipolar affective disorder, manic-depressive illness, or affective... more...

Aliases & Classifications for Bipolar Disorder

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8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases


Aliases & Descriptions:

bipolar disorder 8 43 20 10 45 34 62
manic depression 8 43
manic disorder 8 62
manic bipolar affective disorder 8
bipolar disorder manic phase 8
bipolar affective disorder 43
manic-depressive psychosis 43
affective disorder, major 62
manic depressive disorder 8
manic bipolar i disorder 8
major affective disorder 43
affective disorder major 45
bipolar disorder, mixed 62
mixed bipolar disorder 8
depression, bipolar 62
depressive disorder 62
depression bipolar 45
bipolar depression 8
bipolar illness 43


Related Diseases for Bipolar Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.7GRM1, NDUFV2, BDNF, NRG1, SYN2, RELN
2major depressive disorder31.2ALG9
3mood disorder31.1DAOA, GNAL, TPH1, RELN, NRG1, BDNF
4schizoaffective disorder31.1DAOA, BDNF
5anxiety disorder30.9TPH1, BDNF
6attention deficit hyperactivity disorder30.9SLC6A3, BDNF
7substance dependence30.9SLC6A3, TPH1
8personality disorder30.8TPH1, SLC6A3
9obsessive-compulsive disorder30.5BDNF, SLC6A3, TPH1
10eating disorder30.4BDNF, SLC6A3
11psychotic disorder30.3DAOA, TPH1, RELN, NRG1, BDNF, SLC6A3
12memory impairment30.3SLC6A3, BDNF
13anorexia nervosa30.1KCNN3, BDNF, TPH1
14brain disease10.5
15neuronitis10.5
16bipolar i disorder10.4
17borderline personality disorder10.4
18alcohol dependence10.4
19conduct disorder10.4
20cocaine dependence10.4
21substance abuse10.4
22blindness10.4
23paranoid schizophrenia10.4
24color blindness10.4
25panic disorder10.3
26dementia10.3
27thalassemia10.3
28thyroiditis10.3
29mutism10.3
30alcohol abuse10.3
31obesity10.3
32pervasive developmental disorder10.3
33mental retardation10.3
34early-onset schizophrenia10.3
35major affective disorder 510.2
36major affective disorder 610.2
37major affective disorder 410.2
38major affective disorder 110.2
39major affective disorder 210.2
40autoimmune thyroiditis10.2
41frontotemporal dementia10.2
42autistic disorder10.2
43cerebritis10.2
44trichotillomania10.2
45generalized anxiety disorder10.2
46intellectual disability10.2
47insomnia10.2
48major affective disorder 3, early onset10.2
49transvestism10.1
50exophthalmos10.1

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to bipolar disorder

Symptoms for Bipolar Disorder

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Drugs & Therapeutics for Bipolar Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Bipolar Disorder

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Sources:
20GeneTests
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Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder20

Anatomical Context for Bipolar Disorder

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33MalaCards
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MalaCards organs/tissues related to Bipolar Disorder:

33
Brain, Cortex, Eye, Prefrontal cortex, Cingulate cortex, Testes, Amygdala, Thyroid, Pituitary, Temporal lobe, Monocytes, Cerebellum, Heart, Thalamus, B lymphoblasts, Endothelial, T cells, Kidney, Skin

Animal Models for Bipolar Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bipolar Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.7SLC6A3, GNAL, BDNF, SYN2
2MP:00053699.4GRM1, RELN, SLC6A3, CIT, TPH1, NRG1
3MP:00053898.9BDNF, GRM1, NRG1, RELN, CIT, KCNN3
4MP:00053788.7RELN, PCLO, NRG1, GNAL, TPH1, GRM1
5MP:00053868.6BDNF, TPH1, CIT, RELN, SYN2, NRG1
6MP:00107688.5IMPA1, PCLO, GNAL, CIT, NRG1, GRM1
7MP:00036318.5IMPA1, CIT, RELN, PCLO, NRG1, GRM1

Publications for Bipolar Disorder

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Sources:
52PubMed
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Articles related to Bipolar Disorder:

(show top 50)    (show all 1477)
idTitleAuthorsYear
1
Correlates of depression in bipolar disorder. (24352942)
2014
2
Enhanced fidelity to treatment for bipolar disorder: results from a randomized controlled implementation trial. (24129806)
2014
3
Bipolar disorder - underdiagnosis and HoNOS-PbR. (23995210)
2013
4
Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder. (24119150)
2013
5
Pharmacotherapy of bipolar disorder in children and adolescents: an update. (24402215)
2013
6
Screening for Bipolar Disorder Symptoms in Depressed Primary Care Attenders: Comparison between Mood Disorder Questionnaire and Hypomania Checklist (HCL-32). (24236281)
2013
7
Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. (23044341)
2013
8
Smoking and suicidality in subjects with bipolar disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23658140)
2013
9
Child Behavior Checklist-Mania Scale (CBCL-MS): development and evaluation of a population-based screening scale for bipolar disorder. (23967059)
2013
10
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
11
Menstrual psychosis: presenting symptom of bipolar disorder not otherwise specified in a 13-years-old Hispanic female. (24282923)
2013
12
Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder. (23904016)
2013
13
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
14
Wearable Monitoring for Mood Recognition in Bipolar Disorder based on History-Dependent Long-Term Heart Rate Variability Analysis. (24240031)
2013
15
Self-reported creativity in bipolar disorder: prevalence, types and associated outcomes in mania versus hypomania. (24084622)
2013
16
Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. (23863861)
2013
17
Bipolar disorder and interferon treatment: how to manage? (23817449)
2013
18
Effect of epigallocatechin gallate supplementation in schizophrenia and bipolar disorder: an 8-week, randomized, double-blind, placebo-controlled study. (23983989)
2013
19
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. (20368704)
2011
20
Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population. (20537720)
2011
21
Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples. (21507135)
2011
22
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. (20157312)
2011
23
Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. (22085476)
2011
24
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
25
Evidence for genetic association of RORB with bipolar disorder. (19909500)
2009
26
Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia. (18514404)
2008
27
Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism. (17895927)
2007
28
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. (17015812)
2006
29
Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder. (16359584)
2006
30
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. (16861106)
2006
31
Effect of risperidone on plasma catecholamine metabolites and brain-derived neurotrophic factor in patients with bipolar disorders. (17029305)
2006
32
Family, twin, adoption, and molecular genetic studies of juvenile bipolar disorder. (16403185)
2005
33
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
34
MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. (15992519)
2005
35
Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. (15885920)
2005
36
Long-term observational comparison of risperidone and olanzapine in bipolar disorder. (15328900)
2004
37
Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. (15127079)
2004
38
Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. (12716249)
2003
39
Identifying bipolar disorders in individuals with intellectual disability. (12558693)
2003
40
Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders. (12890311)
2003
41
Valproate, bipolar disorder and polycystic ovarian syndrome. (12656935)
2003
42
Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder. (14604458)
2003
43
No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. (12951196)
2003
44
A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. (12097806)
2002
45
The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder. (15014728)
2002
46
Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. (11304827)
2001
47
Association studies of candidate genes in bipolar disorders. (11093065)
2000
48
Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder. (11252663)
1999
49
Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. (8935216)
1996
50
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. (8950413)
1996

Variations for Bipolar Disorder

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Expression for genes affiliated with Bipolar Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for genes affiliated with Bipolar Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome, 30KEGG
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Pathways related to Bipolar Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9BDNF, YWHAH, TPH1
2
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.9YWHAH, NRG1, BDNF
3
Show member pathways
9.8GNAL, TPH1, GRM1, SLC6A3
4
Show member pathways
9.8BDNF, SLC6A3, NDUFV2, GNAL
5
Show member pathways
9.8SLC6A3, SYN2, GNAL, KCNN3
6
Show member pathways
9.6GNAL, GRM1, NRG1, CACNG5, BDNF
7
Show member pathways
9.5BDNF, NRG1, CACNG5, GNAL, YWHAH
8
Show member pathways
9.5GNAL, BDNF, NRG1, CACNG5, YWHAH
9
Show member pathways
9.5GNAL, CIT, CACNG5, NRG1, BDNF

Compounds for genes affiliated with Bipolar Disorder

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1carbidopa45 2911.6TPH1, SLC6A3
2mdma4510.6SLC6A3, TPH1
3D-Myo-inositol 4-phosphate2410.5IMPA1, IMPA2
4Myo-inositol 1-phosphate2410.5IMPA2, IMPA1
5Inositol phosphate2410.5IMPA2, IMPA1
61D-myo-Inositol 3-phosphate2410.5IMPA1, IMPA2
7Myoinositol2410.5IMPA1, IMPA2
8inositol monophosphate4510.5IMPA2, IMPA1
9antidepressants5110.5BDNF, TPH1
10escitalopram45 51 24 1113.5BDNF, SLC6A3
11quisqualate45 1111.4BDNF, GRM1
12maoa4510.4TPH1, BDNF, SLC6A3
13fluvoxamine45 51 1112.4SLC6A3, BDNF, TPH1
14homovanillic acid45 2411.4BDNF, TPH1
15paroxetine45 51 29 1113.4TPH1, BDNF, SLC6A3
16alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4510.4BDNF, GRM1
17methamphetamine45 51 1112.4SLC6A3, BDNF, TPH1
18fluoxetine45 51 29 1113.4TPH1, BDNF, SLC6A3
19pilocarpine45 29 1112.4BDNF, GRM1
20pramipexole45 29 51 1113.4BDNF, SLC6A3
21citalopram45 51 24 1113.4SLC6A3, BDNF, TPH1
22levodopa45 1111.4SLC6A3, BDNF, TPH1
231 methyl 4 phenylpyridinium4510.4BDNF, SLC6A3
24venlafaxine45 51 24 1113.3BDNF, SLC6A3
25choline45 24 1112.3SLC6A3, BDNF, TPH1
26heroin45 51 1112.3SLC6A3, BDNF
27carbachol45 29 1112.2BDNF, GRM1, NRG1
28inositol4510.2BDNF, IMPA2, IMPA1
29lithium45 51 24 1113.2IMPA1, IMPA2, BDNF, TPH1
30valproate4510.2RELN, BDNF, SLC6A3, IMPA1
31acetylcholine45 51 29 24 1114.2SLC6A3, BDNF, NRG1, TPH1
32selegiline45 1111.2SLC6A3, BDNF
33proline4510.1DAOA, NRG1, GRM1, BDNF
34valine4510.1TPH1, BDNF, SLC6A3
35forskolin45 51 1112.1TPH1, NRG1, GRM1, BDNF
36potassium45 24 1112.1BDNF, GRM1, NRG1, KCNN3
37thapsigargin45 6111.1SLC6A3, BDNF, GRM1
38inositol 1,4,5 trisphosphate4510.1IMPA1, BDNF, GRM1
39nortriptyline51 45 29 1113.0BDNF, SLC6A3
40phosphoinositide4510.0RELN, NRG1, GRM1, BDNF, IMPA1
41dopamine45 29 24 1112.9DAOA, TPH1, NRG1, GRM1, BDNF, SLC6A3
42nmda45 2910.9DAOA, RELN, NRG1, GRM1, BDNF, SLC6A3
43gaba459.9SLC6A3, BDNF, GRM1, NRG1, RELN, TPH1
44ketamine45 29 1111.8SLC6A3, BDNF
45cyclic amp45 2410.8TPH1, NRG1, GRM1, BDNF
46glutamate459.8DAOA, TPH1, RELN, NRG1, GRM1, BDNF
47tyrosine459.4BDNF, GRM1, NRG1, RELN, TPH1, YWHAH
48calcium45 51 24 1112.1KCNN3, TPH1, RELN, PCLO, CACNG5, NRG1

GO Terms for genes affiliated with Bipolar Disorder

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Sources:
16Gene Ontology
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Cellular components related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.8BDNF, PCLO, SYN2

Biological processes related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inositol biosynthetic processGO:00602110.3IMPA2, IMPA1
2inositol phosphate dephosphorylationGO:04685510.2IMPA2, IMPA1
3phosphate-containing compound metabolic processGO:00679610.1IMPA2, IMPA1
4negative regulation of dendrite morphogenesisGO:05077410.1CIT, YWHAH
5dendrite developmentGO:01635810.1RELN, BDNF, CIT
6positive regulation of protein tyrosine kinase activityGO:06109810.0NRG1, RELN
7locomotory behaviorGO:00762610.0NRG1, GRM1, SLC6A3
8phosphatidylinositol phosphorylationGO:0468549.8IMPA1, IMPA2
9synaptic transmissionGO:0072689.8KCNN3, GNAL, SYN2, GRM1, SLC6A3

Molecular functions related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol monophosphate 1-phosphatase activityGO:00893410.1IMPA1, IMPA2
2inositol monophosphate 3-phosphatase activityGO:05283210.0IMPA1, IMPA2
3inositol monophosphate 4-phosphatase activityGO:0528339.8IMPA1, IMPA2
4metal ion bindingGO:0468729.4CIT, RELN, NDUFV2, IMPA2, IMPA1, GNAL

Products for genes affiliated with Bipolar Disorder

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  • Antibodies
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Sources for Bipolar Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet