MCID: BPL003
MIFTS: 77

Bipolar Disorder malady

Genetic diseases, Rare diseases, Mental diseases categories
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Summaries for Bipolar Disorder

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MedlinePlus:33 Bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards based summary: Bipolar Disorder, also known as manic bipolar affective disorder, is related to major depressive disorder and personality disorder. An important gene associated with Bipolar Disorder is ALG9 (ALG9, alpha-1,2-mannosyltransferase), and among its related pathways are SIDS Susceptibility Pathways and Development EGFR signaling pathway. The drugs carbamazepine and clonazepam and the compounds carbidopa and mdma have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related mouse phenotypes are taste/olfaction and muscle.

Disease Ontology:8 A mood disorder that involves alternating periods of mania and depression.

NIH Rare Diseases:42 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia:65 Bipolar disorder, also known as bipolar affective disorder (and originally called manic-depressive... more...

Aliases & Classifications for Bipolar Disorder

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Bipolar Disorder, Aliases & Descriptions:

Name: Bipolar Disorder 30 8 42 20 10 44 33 62
Manic Bipolar Affective Disorder 8 62
Bipolar Disorder Manic Phase 8 62
Bipolar Affective Disorder 42 62
Manic Depressive Disorder 8 62
Manic Bipolar I Disorder 8 62
Manic Depression 8 42
Manic Disorder 8 62
Psychosis, Manic-Depressive 62
Manic-Depressive Psychosis 42
 
Affective Disorder, Major 62
Major Affective Disorder 42
Affective Disorder Major 44
Bipolar Disorder, Mixed 62
Mixed Bipolar Disorder 8
Depressive Disorder 62
Depression, Bipolar 62
Depression Bipolar 44
Bipolar Depression 8
Bipolar Illness 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases


Related Diseases for Bipolar Disorder

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Diseases in the Bipolar Disorder family:

Bipolar I Disorder Bipolar Ll Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1major depressive disorder31.7ALG9
2personality disorder31.4SLC6A3, TPH1
3attention deficit hyperactivity disorder31.4BDNF, SLC6A3
4schizoaffective disorder31.4BDNF, DAOA
5anxiety disorder31.4TPH1, BDNF
6substance dependence31.4SLC6A3, TPH1
7schizophrenia31.2SYN2, RELN, TPH1, GNAL, YWHAH, KCNN3
8mood disorder31.1IMPA1, IMPA2, SLC6A3, BDNF, NRG1, RELN
9obsessive-compulsive disorder31.0SLC6A3, BDNF, TPH1
10memory impairment30.6SLC6A3, BDNF
11eating disorder30.6SLC6A3, BDNF
12psychotic disorder30.5DAOA, TPH1, RELN, NRG1, GRM1, BDNF
13anorexia nervosa30.5BDNF, TPH1, KCNN3
14alzheimer's disease30.3TPH1, RELN, NRG1, BDNF, SLC6A3
15neuronitis10.6
16brain disease10.5
17borderline personality disorder10.5
18bipolar i disorder10.4
19cocaine dependence10.4
20alcohol dependence10.4
21blindness10.4
22conduct disorder10.4
23substance abuse10.4
24paranoid schizophrenia10.4
25color blindness10.4
26panic disorder10.4
27dementia10.4
28aids dementia complex10.3BDNF, SLC6A3
29thalassemia10.3
30thyroiditis10.3
31drug addiction10.3SLC6A3, BDNF
32central nervous system disease10.3SLC6A3, BDNF, GRM1
33prion disease10.3SLC6A3, BDNF, NRG1
34temporal lobe epilepsy10.3RELN, GRM1, BDNF
35mutism10.3
36alcohol abuse10.3
37obesity10.3
38trichotillomania10.3
39pervasive developmental disorder10.3
40mental retardation10.3
41major affective disorder 510.2
42major affective disorder 610.2
43major affective disorder 410.2
44major affective disorder 110.2
45major affective disorder 210.2
46parkinson's disease10.2SLC6A3, BDNF, GRM1, TPH1
47autistic disorder10.2
48autoimmune thyroiditis10.2
49generalized anxiety disorder10.2
50frontotemporal dementia10.2

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to bipolar disorder

Symptoms for Bipolar Disorder

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Drugs & Therapeutics for Bipolar Disorder

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Genetic Tests for Bipolar Disorder

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Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder20

Anatomical Context for Bipolar Disorder

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MalaCards organs/tissues related to Bipolar Disorder:

32
Brain, Cortex, Eye, Prefrontal cortex, Cingulate cortex, Testes, Amygdala, Thyroid, Cerebellum, Monocytes, Temporal lobe, Pituitary, Heart, Kidney, Skin, T cells, B lymphoblasts, Endothelial, Thalamus

Animal Models for Bipolar Disorder or affiliated genes

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MGI Mouse Phenotypes related to Bipolar Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.7GNAL, SYN2, BDNF, SLC6A3
2MP:00053699.4SLC6A3, GRM1, NRG1, RELN, CIT, TPH1
3MP:00053898.9KCNN3, CIT, RELN, NRG1, GRM1, BDNF
4MP:00053788.7GNAL, TPH1, CIT, RELN, PCLO, NRG1
5MP:00053868.6IMPA1, GNAL, TPH1, CIT, RELN, SYN2
6MP:00107688.5RELN, CIT, GNAL, KCNN3, PCLO, NRG1
7MP:00036318.5SYN2, RELN, CIT, KCNN3, PCLO, NRG1

Publications for Bipolar Disorder

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Articles related to Bipolar Disorder:

(show top 50)    (show all 1529)
idTitleAuthorsYear
1
Correlates of depression in bipolar disorder. (24352942)
2014
2
Enhanced fidelity to treatment for bipolar disorder: results from a randomized controlled implementation trial. (24129806)
2014
3
Bipolar disorder - underdiagnosis and HoNOS-PbR. (23995210)
2013
4
Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder. (24119150)
2013
5
Pharmacotherapy of bipolar disorder in children and adolescents: an update. (24402215)
2013
6
Screening for Bipolar Disorder Symptoms in Depressed Primary Care Attenders: Comparison between Mood Disorder Questionnaire and Hypomania Checklist (HCL-32). (24236281)
2013
7
Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. (23044341)
2013
8
Smoking and suicidality in subjects with bipolar disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23658140)
2013
9
Child Behavior Checklist-Mania Scale (CBCL-MS): development and evaluation of a population-based screening scale for bipolar disorder. (23967059)
2013
10
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
11
Menstrual psychosis: presenting symptom of bipolar disorder not otherwise specified in a 13-years-old Hispanic female. (24282923)
2013
12
Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder. (23904016)
2013
13
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
14
Wearable Monitoring for Mood Recognition in Bipolar Disorder based on History-Dependent Long-Term Heart Rate Variability Analysis. (24240031)
2013
15
Self-reported creativity in bipolar disorder: prevalence, types and associated outcomes in mania versus hypomania. (24084622)
2013
16
Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. (23863861)
2013
17
Bipolar disorder and interferon treatment: how to manage? (23817449)
2013
18
Effect of epigallocatechin gallate supplementation in schizophrenia and bipolar disorder: an 8-week, randomized, double-blind, placebo-controlled study. (23983989)
2013
19
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. (20368704)
2011
20
Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population. (20537720)
2011
21
Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples. (21507135)
2011
22
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. (20157312)
2011
23
Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. (22085476)
2011
24
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
25
Evidence for genetic association of RORB with bipolar disorder. (19909500)
2009
26
Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia. (18514404)
2008
27
Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism. (17895927)
2007
28
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. (17015812)
2006
29
Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder. (16359584)
2006
30
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. (16861106)
2006
31
Effect of risperidone on plasma catecholamine metabolites and brain-derived neurotrophic factor in patients with bipolar disorders. (17029305)
2006
32
Family, twin, adoption, and molecular genetic studies of juvenile bipolar disorder. (16403185)
2005
33
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
34
MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. (15992519)
2005
35
Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. (15885920)
2005
36
Long-term observational comparison of risperidone and olanzapine in bipolar disorder. (15328900)
2004
37
Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. (15127079)
2004
38
Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. (12716249)
2003
39
Identifying bipolar disorders in individuals with intellectual disability. (12558693)
2003
40
Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders. (12890311)
2003
41
Valproate, bipolar disorder and polycystic ovarian syndrome. (12656935)
2003
42
Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder. (14604458)
2003
43
No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. (12951196)
2003
44
A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. (12097806)
2002
45
The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder. (15014728)
2002
46
Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. (11304827)
2001
47
Association studies of candidate genes in bipolar disorders. (11093065)
2000
48
Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder. (11252663)
1999
49
Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. (8935216)
1996
50
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. (8950413)
1996

Variations for Bipolar Disorder

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Expression for genes affiliated with Bipolar Disorder

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Expression patterns in normal tissues for genes affiliated with Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for genes affiliated with Bipolar Disorder

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Pathways related to Bipolar Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9BDNF, TPH1, YWHAH
2
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.9YWHAH, NRG1, BDNF
3
Show member pathways
9.8GNAL, TPH1, GRM1, SLC6A3
4
Show member pathways
9.8SLC6A3, BDNF, NDUFV2, GNAL
5
Show member pathways
9.8KCNN3, GNAL, SYN2, SLC6A3
6
Show member pathways
9.6BDNF, GRM1, NRG1, CACNG5, GNAL
7
Show member pathways
9.5BDNF, NRG1, CACNG5, GNAL, YWHAH
8
Show member pathways
9.5YWHAH, GNAL, CACNG5, NRG1, BDNF
9
Show member pathways
9.5BDNF, NRG1, CACNG5, CIT, GNAL

Compounds for genes affiliated with Bipolar Disorder

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Compounds related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1carbidopa44 2811.6TPH1, SLC6A3
2mdma4410.6SLC6A3, TPH1
3D-Myo-inositol 4-phosphate2410.5IMPA1, IMPA2
4Myo-inositol 1-phosphate2410.5IMPA2, IMPA1
5Inositol phosphate2410.5IMPA2, IMPA1
61D-myo-Inositol 3-phosphate2410.5IMPA1, IMPA2
7Myoinositol2410.5IMPA1, IMPA2
8inositol monophosphate4410.5IMPA2, IMPA1
9antidepressants5010.5BDNF, TPH1
10escitalopram44 50 24 1113.5BDNF, SLC6A3
11quisqualate44 1111.4BDNF, GRM1
12maoa4410.4TPH1, BDNF, SLC6A3
13fluvoxamine44 50 1112.4SLC6A3, BDNF, TPH1
14homovanillic acid44 2411.4BDNF, TPH1
15paroxetine44 50 28 1113.4TPH1, BDNF, SLC6A3
16alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4410.4BDNF, GRM1
17methamphetamine44 50 1112.4SLC6A3, BDNF, TPH1
18fluoxetine44 50 28 1113.4TPH1, BDNF, SLC6A3
19pilocarpine44 28 1112.4BDNF, GRM1
20pramipexole44 28 50 1113.4BDNF, SLC6A3
21citalopram44 50 24 1113.4SLC6A3, BDNF, TPH1
22levodopa44 1111.4SLC6A3, BDNF, TPH1
231 methyl 4 phenylpyridinium4410.4BDNF, SLC6A3
24venlafaxine44 50 24 1113.3BDNF, SLC6A3
25choline44 24 1112.3SLC6A3, BDNF, TPH1
26heroin44 50 1112.3SLC6A3, BDNF
27carbachol44 28 1112.2BDNF, GRM1, NRG1
28inositol4410.2BDNF, IMPA2, IMPA1
29lithium44 50 24 1113.2IMPA1, IMPA2, BDNF, TPH1
30valproate4410.2RELN, BDNF, SLC6A3, IMPA1
31acetylcholine44 50 28 24 1114.2SLC6A3, BDNF, NRG1, TPH1
32selegiline44 1111.2SLC6A3, BDNF
33proline4410.1DAOA, NRG1, GRM1, BDNF
34valine4410.1TPH1, BDNF, SLC6A3
35forskolin44 50 1112.1TPH1, NRG1, GRM1, BDNF
36potassium44 24 1112.1BDNF, GRM1, NRG1, KCNN3
37thapsigargin44 6111.1SLC6A3, BDNF, GRM1
38inositol 1,4,5 trisphosphate4410.1IMPA1, BDNF, GRM1
39nortriptyline50 44 28 1113.0BDNF, SLC6A3
40phosphoinositide4410.0RELN, NRG1, GRM1, BDNF, IMPA1
41dopamine44 28 24 1112.9DAOA, TPH1, NRG1, GRM1, BDNF, SLC6A3
42nmda44 2810.9DAOA, RELN, NRG1, GRM1, BDNF, SLC6A3
43gaba449.9SLC6A3, BDNF, GRM1, NRG1, RELN, TPH1
44ketamine44 28 1111.8SLC6A3, BDNF
45cyclic amp44 2410.8TPH1, NRG1, GRM1, BDNF
46glutamate449.8DAOA, TPH1, RELN, NRG1, GRM1, BDNF
47tyrosine449.4BDNF, GRM1, NRG1, RELN, TPH1, YWHAH
48calcium44 50 24 1112.1KCNN3, TPH1, RELN, PCLO, CACNG5, NRG1

GO Terms for genes affiliated with Bipolar Disorder

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Cellular components related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.8BDNF, PCLO, SYN2

Biological processes related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inositol biosynthetic processGO:00602110.3IMPA1, IMPA2
2inositol phosphate dephosphorylationGO:04685510.2IMPA1, IMPA2
3phosphatidylinositol phosphorylationGO:04685410.1IMPA1, IMPA2
4negative regulation of dendrite morphogenesisGO:05077410.1YWHAH, CIT
5dendrite developmentGO:01635810.1BDNF, RELN, CIT
6positive regulation of protein tyrosine kinase activityGO:06109810.0RELN, NRG1
7locomotory behaviorGO:00762610.0SLC6A3, GRM1, NRG1
8phosphate-containing compound metabolic processGO:0067969.8IMPA1, IMPA2
9synaptic transmissionGO:0072689.8KCNN3, GNAL, SYN2, GRM1, SLC6A3

Molecular functions related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol monophosphate 1-phosphatase activityGO:00893410.1IMPA1, IMPA2
2inositol monophosphate 3-phosphatase activityGO:05283210.0IMPA1, IMPA2
3inositol monophosphate 4-phosphatase activityGO:0528339.8IMPA1, IMPA2
4metal ion bindingGO:0468729.4CIT, RELN, NDUFV2, IMPA2, IMPA1, GNAL

Products for genes affiliated with Bipolar Disorder

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Sources for Bipolar Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet