MCID: BPL003
MIFTS: 76

Bipolar Disorder malady

Neuronal category

Summaries for Bipolar Disorder

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards: Bipolar Disorder, also known as manic depression, is related to major depressive disorder and schizoaffective disorder. An important gene associated with Bipolar Disorder is ALG9 (ALG9, alpha-1,2-mannosyltransferase), and among its related pathways are Circadian entrainment and SIDS Susceptibility Pathways. The drugs carbamazepine and clonazepam and the compounds calcium and dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A mood disorder that involves alternating periods of mania and depression.

NIH Rare Diseases:43 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia:64 Bipolar disorder, also known as bipolar affective disorder, manic-depressive disorder, or manic... more...

Aliases & Classifications for Bipolar Disorder

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

bipolar disorder 8 43 20 10 45 34 61
manic depression 8 43
manic disorder 8 61
manic bipolar affective disorder 8
bipolar disorder manic phase 8
bipolar affective disorder 43
manic-depressive psychosis 43
affective disorder, major 61
manic depressive disorder 8
manic bipolar i disorder 8
affective disorder major 45
major affective disorder 43
bipolar disorder, mixed 61
mixed bipolar disorder 8
depressive disorder 61
depression, bipolar 61
depression bipolar 45
bipolar depression 8
bipolar illness 43


Related Diseases for Bipolar Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Bipolar Disorder family:

bipolar ll disorder bipolar i disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1major depressive disorder31.1ALG9
2schizoaffective disorder31.0COMT, SLC6A4, BDNF, DAOA
3anxiety disorder30.9SLC6A4, TPH1, BDNF
4substance dependence30.8SLC6A3, DRD5, SLC6A4, TPH1, COMT
5attention deficit hyperactivity disorder30.7SLC6A3, DRD5, SLC6A4, BDNF, COMT
6borderline personality disorder30.6TPH1, SLC6A4
7alcohol dependence30.6SLC6A4
8panic disorder30.6SLC6A4, COMT, TPH1
9conduct disorder30.6COMT, DRD5, SLC6A3, SLC6A4
10substance abuse30.6SLC6A4, SLC6A3
11cocaine dependence30.5SLC6A3, SLC6A4
12obsessive-compulsive disorder30.5SLC6A3, TPH1, BDNF, SLC6A4, COMT
13alcohol abuse30.4COMT, SLC6A3, SLC6A4
14mental retardation30.4COMT, TPH1, RELN, BDNF
15autistic disorder30.4BDNF, SLC6A4, RELN
16generalized anxiety disorder30.3SLC6A4, TPH1
17antisocial personality disorder30.1SLC6A4, SLC6A3
18narcolepsy30.1COMT
19parkinson's disease30.1SLC6A3, BDNF, COMT
20essential tremor30.1SLC6A3
21alzheimer's disease29.9TPH1, SLC6A4, SLC6A3, RELN, NRG1, BDNF
22anorexia nervosa29.9BDNF, TPH1, SLC6A4, COMT, KCNN3
23bulimia nervosa29.9SLC6A4, COMT, BDNF
24cocaine abuse29.9SLC6A3, SLC6A4
25nicotine dependence29.9SLC6A4
26social phobia29.9SLC6A4, COMT
27pathological gambling29.9SLC6A3
28seasonal affective disorder29.9TPH1, SLC6A4
29dopa-responsive cervical dystonia29.8TPH1, BDNF, SLC6A4
30temporal lobe epilepsy29.8BDNF, GRM1, RELN
31bipolar i disorder11.3
32dysthymic disorder10.4
33major depressive disorder 210.4
34sleep disorder10.3
35blindness10.3
36thalassemia10.3
37thalassemia minor10.3
38alexithymia10.3
39brain disease10.3
40early-onset schizophrenia10.3
41mutism10.2
42major affective disorder 510.2
43major affective disorder 610.2
44major affective disorder 410.2
45major affective disorder 110.2
46major affective disorder 210.2
47conversion disorder10.2
48autoimmune thyroiditis10.2
49trichotillomania10.2
50frontotemporal dementia10.2

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to bipolar disorder

Clinical Features for Bipolar Disorder

Drugs & Therapeutics for Bipolar Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bipolar Disorder

Drug clinical trials:

Search ClinicalTrials for Bipolar Disorder

Search NIH Clinical Center for Bipolar Disorder

Highlights from CenterWatch's Drugs in Clinical Trials Database for Bipolar Disorder:

idCompanyCompoundMechanismPhase
1ElanELND005an orally available small molecule amyloid beta peptide aggregation inhibitorII
2TakedaramelteonAn ML1-selective melatonin receptor agonistIII

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Bipolar Disorder

Sources:
20GeneTests
See all sources

Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder20

Anatomical Context for Bipolar Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bipolar Disorder:

33
Skin, Ovary, Brain, Kidney, Bone marrow, Whole blood, Cortex, Cerebellum, Heart, Thyroid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Thalamus, Amygdala, Adrenal cortex, Pituitary

Animal Models for Bipolar Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bipolar Disorder

Sources:
51PubMed
See all sources

Articles related to Bipolar Disorder:

(show top 50)    (show all 2303)
idTitleAuthorsYear
1
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
2
Clozapine-induced obsessive-compulsive symptoms in bipolar disorder. (23903341)
2013
3
Aripiprazole for the treatment and prevention of acute manic and mixed episodes in bipolar i disorder in children and adolescents: a NICE single technology appraisal. (24092620)
2013
4
Performance on a computerized shopping task significantly predicts real world functioning in persons diagnosed with bipolar disorder. (23870492)
2013
5
Meta-analysis of predictors of favorable employment outcomes among individuals with bipolar disorder. (24219657)
2013
6
Deformations of amygdala morphology in familial pediatric bipolar disorder. (24034354)
2013
7
Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations. (23715300)
2013
8
Transient febrile reaction after electroconvulsive therapy (ECT) in a young adult with intellectual disability and bipolar disorder. (23774055)
2013
9
Could comorbid bipolar disorder account for a significant share of executive function deficits in adults with attention-deficit hyperactivity disorder? (24286629)
2013
10
Dysfunctional family environment in affected versus unaffected offspring of parents with bipolar disorder. (24108060)
2013
11
Long-term efficacy of quetiapine in combination with lithium or divalproex on mixed symptoms in bipolar I disorder. (23062763)
2012
12
Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder. (22629103)
2012
13
Sensitivity and specificity of the mood disorder questionnaire and the bipolar spectrum diagnostic scale in Argentinean patients with mood disorders. (21440943)
2011
14
Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder. (20446090)
2011
15
Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis. (20594600)
2011
16
Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics. (21034695)
2011
17
Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder. (20810001)
2011
18
Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (19554614)
2010
19
CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. (19916019)
2010
20
Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. (20122740)
2010
21
Morbidity in 303 first-episode bipolar I disorder patients. (20565433)
2010
22
Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. (19851515)
2009
23
Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. (19352219)
2009
24
Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study. (19906348)
2009
25
Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. (19290059)
2009
26
Do schizophrenia and bipolar disorders share a common disease susceptibility variant at the MMP3 gene? (19245826)
2009
27
The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. (19059449)
2009
28
Lamotrigine and bipolar disorder: new indication. Only after lithium, like other antiepileptics. Preventive effects in only one aspect of bipolar disorder, but with a risk of Lyell syndrome. (19882784)
2009
29
Expression of cellular prion protein (PrP(c)) in schizophrenia, bipolar disorder, and depression. (18188498)
2008
30
The predictive effect of insight on adverse clinical outcomes in bipolar I disorder: a two-year prospective study. (17997489)
2008
31
A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. (18789374)
2008
32
Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism. (17895927)
2007
33
Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder. (17136449)
2007
34
NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences. (17413444)
2007
35
Diagnostic characteristics of child bipolar I disorder: does the "Treatment of Early Age Mania (team)" sample generalize? (17335331)
2007
36
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. (16861106)
2006
37
Association study of CHRFAM7A copy number and 2 bp deletion polymorphisms with schizophrenia and bipolar affective disorder. (16823804)
2006
38
Effect of topiramate augmentation on two patients suffering from schizophrenia or bipolar disorder with comorbid alcohol abuse. (16009565)
2005
39
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. (15838535)
2005
40
Antipsychotic Medicines for Treating Schizophrenia and Bipolar Disorder: A Review of the Research for Adults and Caregivers (23741769)
2005
41
Multiple dimensions of familial psychopathology affect risk of mood disorder in children of bipolar parents. (15108177)
2004
42
Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder. (14735135)
2004
43
Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder. (12610649)
2003
44
Linkage disequilibrium between dopamine D1 receptor gene (DRD1) and bipolar disorder. (12488059)
2002
45
Manic episode in epilepsy and bipolar I disorder: a comparative analysis of 13 patients. (11554891)
2001
46
Support for the possible locus on chromosome 4p16 for bipolar affective disorder. (9774780)
1998
47
Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder. (9108818)
1997
48
Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder. (9129712)
1997
49
Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. (8533768)
1995
50
Clinical experience with valproic acid in 22 patients with refractory bipolar mood disorder. (1423164)
1992

Genetic Variations for Bipolar Disorder

Expression for genes affiliated with Bipolar Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for genes affiliated with Bipolar Disorder

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Bipolar Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3COMT, DRD5, GRM1, SLC6A3, SLC6A4
211.1BDNF, YWHAH, SLC6A4, TPH1
3
Hide members
11.0SLC6A3, GRM1, BDNF
410.8IMPA1, IMPA2

Compounds for genes affiliated with Bipolar Disorder

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Bipolar Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.5PCLO, RELN, IMPA2, IMPA1, CACNG5, KCNN3
2dopamine45 29 11 2415.4COMT, BDNF, DRD5, NRG1, GRM1, DAOA
3glutamate4512.4RELN, BDNF, NRG1, COMT, SLC6A4, TPH1
4gaba4512.1SLC6A4, BDNF, NRG1, GRM1, TPH1, RELN
5norepinephrine45 11 2413.9COMT, TPH1, SLC6A3, BDNF, SLC6A4, DRD5
6maoa4511.8SLC6A4, TPH1, SLC6A3, BDNF, COMT
7paroxetine45 50 29 1114.8SLC6A4, COMT, BDNF, SLC6A3, TPH1
8methamphetamine45 50 1113.8BDNF, TPH1, SLC6A4, SLC6A3, COMT
9lithium45 50 11 2414.7SLC6A4, IMPA2, IMPA1, TPH1, BDNF
10levodopa45 1112.7DRD5, COMT, TPH1, BDNF, SLC6A3
11clozapine45 29 50 1114.7SLC6A4, COMT, DRD5, SLC6A3, BDNF
12choline45 11 2413.7COMT, TPH1, SLC6A4, BDNF, SLC6A3
13valine4511.7TPH1, SLC6A3, BDNF, COMT, SLC6A4
14nmda45 2912.6COMT, BDNF, DAOA, SLC6A3
15methylphenidate45 50 1113.6SLC6A3, DRD5, SLC6A4, COMT
16homovanillic acid45 2412.6BDNF, COMT, TPH1, SLC6A4
17pramipexole45 50 29 1114.6COMT, BDNF, DRD5, SLC6A3
18fluvoxamine45 50 1113.6SLC6A3, SLC6A4, TPH1, BDNF
19risperidone29 45 50 60 11 2416.6SLC6A4, COMT, BDNF, SLC6A3
20fluoxetine50 45 29 1114.6TPH1, SLC6A4, BDNF, SLC6A3
21citalopram50 45 11 2414.6TPH1, BDNF, SLC6A3, SLC6A4
22valproate4511.5RELN, BDNF, IMPA1, SLC6A3
23mptp4511.5COMT, SLC6A4, SLC6A3, BDNF
24olanzapine50 45 29 11 2415.5DRD5, BDNF, COMT, SLC6A3
25haloperidol45 29 2 50 1115.5SLC6A3, DRD5, BDNF, SLC6A4
26catecholamine4511.5TPH1, BDNF, DRD5, COMT
27carbidopa45 2912.4COMT, SLC6A3, TPH1
28mdma4511.4SLC6A3, SLC6A4, TPH1
29escitalopram45 50 11 2414.3SLC6A4, SLC6A3, BDNF
30mhpg4511.3COMT, SLC6A4, BDNF
311 methyl 4 phenylpyridinium4511.3BDNF, SLC6A3, SLC6A4
32ketanserin29 4512.3DRD5, SLC6A4, BDNF
33venlafaxine50 45 11 2414.3BDNF, SLC6A3, SLC6A4
34tyramine45 29 2413.3SLC6A4, COMT, SLC6A3
35heroin45 50 1113.3SLC6A3, SLC6A4, COMT
36cocaine45 1112.3SLC6A4, COMT, SLC6A3, BDNF
37selegiline45 1112.2SLC6A3, BDNF, COMT
38nortriptyline45 50 29 1114.2BDNF, SLC6A3, SLC6A4
39bupropion45 50 11 2414.2COMT, SLC6A3, SLC6A4
40ketamine45 29 1113.2SLC6A3, SLC6A4, BDNF
415-methoxy-6-methyl-2-aminoindan4511.1SLC6A4, SLC6A3
42(123i)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane4511.1SLC6A4, SLC6A3
43gbr 129354511.1SLC6A4, SLC6A3
445-hydroxytryptamine4511.0COMT, SLC6A3, SLC6A4, TPH1
452beta-carbomethoxy-3beta-(4-iodophenyl)tropane4511.0SLC6A4, SLC6A3
46apomorphine45 29 1113.0SLC6A3, COMT, DRD5
47rimcazole4511.0SLC6A3, SLC6A4
48p-chlorophenylalanine4510.9TPH1, SLC6A4
49tropane4510.8SLC6A4, SLC6A3
50quetiapine45 50 29 11 2414.7SLC6A3, DRD5, BDNF

GO Terms for genes affiliated with Bipolar Disorder

Sources:
16Gene Ontology
See all sources

Biological processes related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.5COMT, KCNN3, DRD5, GRM1, SLC6A3
2dendrite developmentGO:01635811.2RELN, CIT, BDNF
3locomotory behaviorGO:00762611.1SLC6A3, GRM1, NRG1
4inositol biosynthetic processGO:00602111.1IMPA2, IMPA1
5dopamine catabolic processGO:04242011.1SLC6A3, COMT
6negative regulation of dendrite morphogenesisGO:05077411.0CIT, YWHAH
7monoamine transportGO:01584411.0SLC6A3, SLC6A4
8inositol phosphate dephosphorylationGO:04685511.0IMPA2, IMPA1
9phosphatidylinositol phosphorylationGO:04685410.9IMPA1, IMPA2
10neurotransmitter biosynthetic processGO:04213610.8SLC6A3, COMT
11associative learningGO:00830610.8RELN, DRD5
12positive regulation of protein tyrosine kinase activityGO:06109810.7RELN, NRG1
13response to painGO:04826510.5RELN, COMT

Molecular functions related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol monophosphate 1-phosphatase activityGO:00893410.9IMPA2, IMPA1
2inositol monophosphate 4-phosphatase activityGO:05283310.8IMPA1, IMPA2
3dopamine bindingGO:03524010.8SLC6A3, DRD5
4inositol monophosphate 3-phosphatase activityGO:05283210.7IMPA1, IMPA2
5monoamine transmembrane transporter activityGO:00850410.5SLC6A4, SLC6A3

Products for genes affiliated with Bipolar Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bipolar Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet