MCID: BPL003
MIFTS: 80

Bipolar Disorder malady

Neuronal diseases category

Summaries for Bipolar Disorder

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards: Bipolar Disorder, also known as manic depression, is related to schizophrenia and mood disorder. An important gene associated with Bipolar Disorder is ALG9 (ALG9, alpha-1,2-mannosyltransferase), and among its related pathways are Circadian entrainment and SIDS Susceptibility Pathways. The drugs carbamazepine and clonazepam and the compounds calcium and dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A mood disorder that involves alternating periods of mania and depression.

NIH Rare Diseases:42 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia:63 Bipolar disorder (also known as bipolar affective disorder, manic-depressive disorder, or manic... more...

Aliases & Classifications for Bipolar Disorder

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bipolar disorder 8 42 20 10 44 33 60
manic depression 8 42
manic disorder 8 60
manic bipolar affective disorder 8
bipolar disorder manic phase 8
bipolar affective disorder 42
manic-depressive psychosis 42
affective disorder, major 60
manic depressive disorder 8
manic bipolar i disorder 8
affective disorder major 44
major affective disorder 42
bipolar disorder, mixed 60
mixed bipolar disorder 8
depressive disorder 60
depression, bipolar 60
depression bipolar 44
bipolar depression 8
bipolar illness 42


Related Diseases for Bipolar Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.8COMT, TPH1, KCNN3, BDNF, NDUFV2, DRD5
2mood disorder31.3COMT, BDNF, NRG1, IMPA1, IMPA2, RELN
3major depressive disorder31.2ALG9
4psychotic disorder31.0COMT, BDNF, NRG1, GRM1, RELN, DAOA
5schizoaffective disorder30.9COMT, BDNF, DAOA, SLC6A4
6personality disorder30.9SLC6A3, SLC6A4, TPH1
7anxiety disorder30.8BDNF, SLC6A4, TPH1
8substance dependence30.7COMT, DRD5, SLC6A3, SLC6A4, TPH1
9attention deficit hyperactivity disorder30.7SLC6A4, SLC6A3, DRD5, BDNF, COMT
10borderline personality disorder30.6TPH1, SLC6A4
11alcohol dependence30.6SLC6A4
12panic disorder30.5COMT, SLC6A4, TPH1
13conduct disorder30.5COMT, DRD5, SLC6A3, SLC6A4
14substance abuse30.5SLC6A4, SLC6A3
15cocaine dependence30.5SLC6A3, SLC6A4
16dementia30.4SLC6A3, BDNF, COMT
17obsessive-compulsive disorder30.4COMT, BDNF, SLC6A3, SLC6A4, TPH1
18alcohol abuse30.4COMT, SLC6A3, SLC6A4
19autistic disorder30.3BDNF, RELN, SLC6A4
20eating disorder30.2COMT, BDNF, SLC6A3, SLC6A4
21drug dependence30.2SLC6A4, SLC6A3
22generalized anxiety disorder30.2TPH1, SLC6A4
23migraine30.1COMT, DRD5, SLC6A3, SLC6A4, TPH1
24antisocial personality disorder30.1SLC6A4, SLC6A3
25essential tremor30.1SLC6A3
26narcolepsy30.1COMT
27parkinson's disease30.0SLC6A3, BDNF, COMT
28alzheimer's disease29.9COMT, BDNF, NRG1, RELN, SLC6A3, SLC6A4
29anorexia nervosa29.9TPH1, SLC6A4, BDNF, KCNN3, COMT
30bulimia nervosa29.9COMT, BDNF, SLC6A4
31cocaine abuse29.9SLC6A3, SLC6A4
32endogenous depression29.9SLC6A4, BDNF
33nicotine dependence29.9SLC6A4
34social phobia29.9SLC6A4, COMT
35pathological gambling29.9SLC6A3
36multiple system atrophy29.9SLC6A3
37seasonal affective disorder29.9SLC6A4, TPH1
38temporal lobe epilepsy29.7RELN, GRM1, BDNF
39gilles de la tourette syndrome29.7DRD5, SLC6A3
40breast cancer29.7NRG1, COMT
41huntington's disease29.7BDNF
42bipolar i disorder10.7
43mitochondrial disorders10.6
44neuronitis10.5
45dysthymic disorder10.4
46color blindness10.3
47sleep disorder10.3
48thalassemia10.3
49thyroiditis10.3
50alexithymia10.2

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to bipolar disorder

Clinical Features for Bipolar Disorder

About this section

Drugs & Therapeutics for Bipolar Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bipolar Disorder

Drug clinical trials:

Search ClinicalTrials for Bipolar Disorder

Search NIH Clinical Center for Bipolar Disorder

Highlights from CenterWatch's Drugs in Clinical Trials Database for Bipolar Disorder:

idCompanyCompoundMechanismPhase
1ElanELND005an orally available small molecule amyloid beta peptide aggregation inhibitorII
2TakedaramelteonAn ML1-selective melatonin receptor agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Bipolar Disorder

About this section
Sources:
20GeneTests
See all sources

Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder20

Anatomical Context for Bipolar Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Bipolar Disorder:

32
Brain, Cortex, Prefrontal cortex, Testes, Amygdala, Cingulate cortex, Thyroid, Monocytes, Pituitary, Temporal lobe, B lymphoblasts, Eye, Cerebellum, Kidney, Heart, T cells, Skin, Thalamus, Bone marrow, Ovary, Endothelial, Bone

Animal Models for Bipolar Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Bipolar Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.8SLC6A4, COMT, KCNN3, BDNF, DRD5, CIT
2MP:000538612.4COMT, BDNF, CIT, NRG1, GRM1, IMPA1
3MP:001076812.2KCNN3, BDNF, NDUFV2, CIT, NRG1, GRM1
4MP:000537812.0CIT, NRG1, GRM1, PCLO, RELN, SLC6A3
5MP:000538911.9COMT, KCNN3, BDNF, CIT, NRG1, GRM1
6MP:000536911.7CIT, NRG1, GRM1, RELN, SLC6A3, SLC6A4
7MP:000287311.4BDNF, DRD5, IMPA2, PCLO, GPR125, SLC6A3

Publications for Bipolar Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Bipolar Disorder:

(show top 50)    (show all 2303)
idTitleAuthorsYear
1
Enhanced fidelity to treatment for bipolar disorder: results from a randomized controlled implementation trial. (24129806)
2014
2
DSM-IV diagnosis in depressed primary care patients with previous psychiatric ICD-10 bipolar disorder. (24139284)
2014
3
The impact of limbic system morphology on facial emotion recognition in bipolar I disorder and healthy controls. (23723706)
2013
4
Pharmacotherapy of bipolar disorder in children and adolescents: an update. (24402215)
2013
5
Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder. (23904016)
2013
6
Risky alcohol use in young persons with emerging bipolar disorder is associated with increased oxidative stress. (23838389)
2013
7
Burden and related factors in caregivers of young adults presenting bipolar and unipolar mood disorder. (23828767)
2013
8
Bipolar disorder risk alleles in children with ADHD. (23712748)
2013
9
Organic solvent-induced bipolar disorder: a case report. (23784607)
2013
10
Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder. (22914618)
2013
11
Affective temperament and attachment in adulthood in patients with Bipolar Disorder and Cyclothymia. (24411930)
2013
12
Influence of misdiagnosis on the course of bipolar disorder. (23771544)
2013
13
Impaired retrieval of semantic information in bipolar disorder: a clustering analysis of category-fluency productions. (24016005)
2013
14
Treatment Patterns, HealthCare Resource Utilization and Costs in Patients with Bipolar Disorder, Newly Treated with Extended Release or Immediate Release Quetiapine Fumarate using US Healthcare Administrative Claims Data. (24275622)
2013
15
Lamotrigine-induced facial tic in a pediatric bipolar disorder patient. (24138013)
2013
16
Neural responses to emotional stimuli in comorbid borderline personality disorder and bipolar depression. (22871390)
2012
17
COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes. (22222175)
2012
18
Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode. (22293033)
2012
19
A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. (22420593)
2012
20
A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic or mixed episodes in Asian patients with bipolar I disorder (the AMAZE study). (22540407)
2012
21
Treatment and outcomes of an Australian cohort of outpatients with bipolar I or schizoaffective disorder over twenty-four months: implications for clinical practice. (23244301)
2012
22
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. (20368704)
2011
23
Olanzapine-induced weight gain in patients with bipolar I disorder: a meta-analysis. (22454806)
2011
24
Treatment of bipolar disorder in an adolescent with autistic disorder: a diagnostic and treatment dilemma. (21663432)
2011
25
Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior. (21621268)
2011
26
From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder. (21891869)
2011
27
Angiotensin-converting enzyme polymorphism in schizophrenia, bipolar disorders, and their first-degree relatives. (20010451)
2010
28
Genetic risk for white matter abnormalities in bipolar disorder. (20374152)
2009
29
The safety of olanzapine in adolescents with schizophrenia or bipolar I disorder: a pooled analysis of 4 clinical trials. (19210948)
2009
30
No evidence for excess runs of homozygosity in bipolar disorder. (19451863)
2009
31
Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder. (19395051)
2009
32
Clinical and neurocognitive correlates of insight in patients with bipolar I disorder in remission. (17970840)
2008
33
Impact of remitted substance use disorders on the future course of bipolar I disorder: findings from a clinical trial. (18514326)
2008
34
Comparisons of insight in schizophrenia, bipolar I disorder, and depressive disorders with and without comorbid alcohol use disorder. (19068005)
2008
35
Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. (18657242)
2008
36
The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function. (17547582)
2007
37
"I won't do what you tell me!": elevated mood and the assessment of advice-taking in euthymic bipolar I disorder. (16487480)
2006
38
Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. (16222333)
2006
39
Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil. (15660667)
2005
40
Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders. (15627807)
2005
41
Association analysis of CHMP1.5 genetic variation and bipolar disorder. (16094257)
2005
42
Combination quetiapine therapy in the long-term treatment of patients with bipolar I disorder. (16026618)
2005
43
The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder. (15023493)
2004
44
Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder. (14706725)
2004
45
The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism. (11409699)
2001
46
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. (11525420)
2001
47
Olanzapine-induced psychotic mania in bipolar schizoaffective disorder. (10497709)
1999
48
A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish. (9861003)
1998
49
Inositol monophosphatase--a putative target for Li+ in the treatment of bipolar disorder. (7482796)
1995
50
Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees. (1673974)
1991

Genetic Variations for Bipolar Disorder

About this section

Expression for genes affiliated with Bipolar Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for genes affiliated with Bipolar Disorder

About this section
Sources:
29KEGG, 37NCBI BioSystems Database
See all sources

Pathways related to Bipolar Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3COMT, DRD5, GRM1, SLC6A3, SLC6A4
211.1BDNF, YWHAH, SLC6A4, TPH1
3
Hide members
11.0SLC6A3, GRM1, BDNF
410.8IMPA2, IMPA1

Compounds for genes affiliated with Bipolar Disorder

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Bipolar Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.5PCLO, RELN, CACNG5, IMPA2, IMPA1, TPH1
2dopamine44 28 11 2415.4COMT, BDNF, DRD5, NRG1, GRM1, DAOA
3glutamate4412.4RELN, BDNF, NRG1, COMT, SLC6A4, TPH1
4gaba4412.1SLC6A4, BDNF, NRG1, GRM1, TPH1, RELN
5norepinephrine44 11 2413.9COMT, TPH1, SLC6A3, BDNF, SLC6A4, DRD5
6maoa4411.8SLC6A4, TPH1, SLC6A3, BDNF, COMT
7paroxetine44 49 28 1114.8SLC6A4, COMT, BDNF, SLC6A3, TPH1
8methamphetamine44 49 1113.8BDNF, TPH1, SLC6A4, SLC6A3, COMT
9lithium44 49 11 2414.7SLC6A4, IMPA2, IMPA1, TPH1, BDNF
10levodopa44 1112.7DRD5, COMT, TPH1, BDNF, SLC6A3
11clozapine44 28 49 1114.7SLC6A4, COMT, DRD5, SLC6A3, BDNF
12choline44 11 2413.7COMT, TPH1, SLC6A4, BDNF, SLC6A3
13valine4411.7COMT, SLC6A4, SLC6A3, BDNF, TPH1
14nmda44 2812.6COMT, BDNF, DAOA, SLC6A3
15methylphenidate44 49 1113.6SLC6A3, DRD5, SLC6A4, COMT
16homovanillic acid44 2412.6BDNF, COMT, TPH1, SLC6A4
17pramipexole44 49 28 1114.6COMT, BDNF, DRD5, SLC6A3
18fluvoxamine44 49 1113.6SLC6A3, SLC6A4, TPH1, BDNF
19risperidone28 44 49 59 11 2416.6SLC6A4, COMT, BDNF, SLC6A3
20fluoxetine49 44 28 1114.6TPH1, SLC6A4, BDNF, SLC6A3
21citalopram49 44 11 2414.6TPH1, BDNF, SLC6A3, SLC6A4
22valproate4411.5RELN, BDNF, IMPA1, SLC6A3
23mptp4411.5COMT, SLC6A4, SLC6A3, BDNF
24olanzapine49 44 28 11 2415.5DRD5, BDNF, COMT, SLC6A3
25haloperidol44 28 2 49 1115.5SLC6A4, BDNF, SLC6A3, DRD5
26catecholamine4411.5TPH1, BDNF, DRD5, COMT
27carbidopa44 2812.4COMT, SLC6A3, TPH1
28mdma4411.4SLC6A3, SLC6A4, TPH1
29escitalopram44 49 11 2414.3BDNF, SLC6A3, SLC6A4
30mhpg4411.3BDNF, COMT, SLC6A4
311 methyl 4 phenylpyridinium4411.3BDNF, SLC6A3, SLC6A4
32ketanserin28 4412.3DRD5, SLC6A4, BDNF
33venlafaxine49 44 11 2414.3BDNF, SLC6A3, SLC6A4
34tyramine44 28 2413.3SLC6A4, COMT, SLC6A3
35heroin44 49 1113.3SLC6A3, SLC6A4, COMT
36selegiline44 1112.2SLC6A3, BDNF, COMT
37nortriptyline44 49 28 1114.2BDNF, SLC6A3, SLC6A4
38cocaine44 1112.2COMT, BDNF, SLC6A3, SLC6A4
39bupropion44 49 11 2414.2SLC6A3, SLC6A4, COMT
40ketamine44 28 1113.2SLC6A4, SLC6A3, BDNF
415-methoxy-6-methyl-2-aminoindan4411.1SLC6A4, SLC6A3
42(123i)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane4411.1SLC6A4, SLC6A3
43gbr 129354411.1SLC6A4, SLC6A3
445-hydroxytryptamine4411.0COMT, SLC6A3, SLC6A4, TPH1
452beta-carbomethoxy-3beta-(4-iodophenyl)tropane4411.0SLC6A3, SLC6A4
46apomorphine44 28 1113.0SLC6A3, COMT, DRD5
47rimcazole4411.0SLC6A4, SLC6A3
48p-chlorophenylalanine4410.9TPH1, SLC6A4
49gbr 129094410.8SLC6A3, SLC6A4
50quetiapine44 49 28 11 2414.7DRD5, BDNF, SLC6A3

GO Terms for genes affiliated with Bipolar Disorder

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Bipolar Disorder according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.5COMT, KCNN3, DRD5, GRM1, SLC6A3
2dendrite developmentGO:01635811.2RELN, CIT, BDNF
3locomotory behaviorGO:00762611.1SLC6A3, GRM1, NRG1
4inositol biosynthetic processGO:00602111.1IMPA2, IMPA1
5dopamine catabolic processGO:04242011.1SLC6A3, COMT
6negative regulation of dendrite morphogenesisGO:05077411.0CIT, YWHAH
7monoamine transportGO:01584411.0SLC6A3, SLC6A4
8inositol phosphate dephosphorylationGO:04685511.0IMPA2, IMPA1
9phosphatidylinositol phosphorylationGO:04685410.9IMPA1, IMPA2
10neurotransmitter biosynthetic processGO:04213610.8SLC6A3, COMT
11associative learningGO:00830610.8RELN, DRD5
12positive regulation of protein tyrosine kinase activityGO:06109810.7RELN, NRG1
13response to painGO:04826510.5RELN, COMT

Molecular functions related to Bipolar Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inositol monophosphate 1-phosphatase activityGO:00893410.9IMPA2, IMPA1
2inositol monophosphate 4-phosphatase activityGO:05283310.8IMPA1, IMPA2
3dopamine bindingGO:03524010.8SLC6A3, DRD5
4inositol monophosphate 3-phosphatase activityGO:05283210.7IMPA1, IMPA2
5monoamine transmembrane transporter activityGO:00850410.5SLC6A4, SLC6A3

Products for genes affiliated with Bipolar Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bipolar Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet