MCID: BPL003
MIFTS: 61

Bipolar Disorder

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Bipolar Disorder

MalaCards integrated aliases for Bipolar Disorder:

Name: Bipolar Disorder 37 12 72 49 24 36 51 40 41 14 69
Bipolar Affective Disorder 49 24
Major Affective Disorder 49 69
Depression, Bipolar 24 69
Manic Depression 12 49
Manic Disorder 12 69
Manic Bipolar Affective Disorder 12
Bipolar Disorder Manic Phase 12
Bipolar Affective Psychosis 24
Major Affective Disorder 1 69
Manic-Depressive Psychosis 49
Major Affective Disorder 2 69
Manic Depressive Disorder 12
Bipolar Spectrum Disorder 24
Manic Bipolar I Disorder 12
Manic Depressive Illness 24
Affective Disorder Major 51
Depressive-Manic Psych. 12
Bipolar Disorder, Mixed 69
Mixed Bipolar Disorder 12
Bipolar Depression 12
Depression Bipolar 51
Bipolar Illness 49

Classifications:



Summaries for Bipolar Disorder

MedlinePlus : 40 Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. Abnormal brain structure and function may also play a role. Bipolar disorder often starts in a person's late teen or early adult years. But children and adults can have bipolar disorder too. The illness usually lasts a lifetime. If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes. If not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments to control symptoms: medicine and talk therapy. A combination usually works best. NIH: National Institute of Mental Health

MalaCards based summary : Bipolar Disorder, also known as bipolar affective disorder, is related to schizophrenia and major depressive disorder. An important gene associated with Bipolar Disorder is MAFD1 (Major Affective Disorder 1), and among its related pathways/superpathways is Neurotransmitter Clearance In The Synaptic Cleft. The drugs Aripiprazole and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

NIH Rare Diseases : 49 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). It often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together likely increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. Last updated: 11/18/2011

Genetics Home Reference : 24 Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life.

Disease Ontology : 12 A mood disorder that involves alternating periods of mania and depression.

Wikipedia : 72 Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of... more...

Related Diseases for Bipolar Disorder

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 33.6 ATP2A2 BDNF COMT DAOA DISC1 DRD3
2 major depressive disorder 33.6 BDNF COMT DISC1 DRD3 MTHFR SLC6A4
3 bipolar i disorder 33.3 BDNF COMT NRG1 SLC6A4
4 mood disorder 33.2 BDNF COMT DAOA DISC1 IMPA1 IMPA2
5 schizoaffective disorder 33.2 BDNF COMT DAOA DISC1 DRD3 SLC6A4
6 psychotic disorder 33.1 BDNF COMT DAOA DISC1 DRD3 MTHFR
7 personality disorder 31.7 BDNF COMT DRD3 SLC6A4
8 borderline personality disorder 31.6 BDNF COMT SLC6A4
9 anxiety 31.5 BDNF COMT SLC6A4
10 attention deficit-hyperactivity disorder 31.5 BDNF COMT DRD3 SLC6A4
11 obsessive-compulsive disorder 31.5 BDNF COMT DRD3 SLC6A4
12 substance abuse 31.4 BDNF COMT DRD3 SLC6A4
13 autism 31.4 BDNF COMT DISC1 DRD3 RELN SLC6A4
14 substance dependence 31.4 BDNF DRD3 SLC6A4
15 alcohol dependence 31.3 BDNF COMT DRD3 SLC6A4
16 early-onset schizophrenia 31.2 BDNF COMT DRD3 SLC6A4
17 eating disorder 31.1 BDNF COMT SLC6A4
18 panic disorder 31.1 BDNF COMT SLC6A4
19 alcohol abuse 31.1 BDNF DRD3 SLC6A4
20 migraine with or without aura 1 31.1 COMT DRD3 MTHFR SLC6A4
21 pervasive developmental disorder 31.0 BDNF RELN SLC6A4
22 autism spectrum disorder 31.0 BDNF COMT DISC1 DRD3 RELN SLC6A4
23 disease of mental health 30.8 BDNF COMT DISC1 DRD3 NRG1 RELN
24 postpartum depression 30.7 BDNF COMT SLC6A4
25 bulimia nervosa 1 30.7 BDNF COMT SLC6A4
26 tardive dyskinesia 30.6 COMT DRD3
27 post-traumatic stress disorder 30.6 BDNF COMT SLC6A4
28 bulimia nervosa 2 30.6 BDNF COMT SLC6A4
29 schizophreniform disorder 30.5 COMT NRG1
30 major affective disorder 1 11.3
31 major affective disorder 2 11.3
32 major affective disorder 4 11.3
33 major affective disorder 5 11.3
34 major affective disorder 6 11.3
35 major affective disorder 8 11.3
36 major affective disorder 7 11.3
37 major affective disorder 9 11.3
38 valproate embryopathy 10.9
39 cyclothymic disorder 10.9
40 childhood-onset schizophrenia 10.9 COMT DAOA NRG1
41 paranoid schizophrenia 10.9 BDNF COMT SLC6A4
42 mental depression 10.9 BDNF COMT SLC6A4
43 migraine without aura 10.9 DRD3 MTHFR SLC6A4
44 drug dependence 10.9 BDNF DRD3 SLC6A4
45 specific developmental disorder 10.8 BDNF COMT SLC6A4
46 obsessive-compulsive personality disorder 10.8 DRD3 SLC6A4
47 darier-white disease 10.8
48 mental retardation, x-linked, syndromic 13 10.8
49 schizophrenia 4 10.8
50 schizophrenia 2 10.8

Comorbidity relations with Bipolar Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetes Insipidus, Nephrogenic, Autosomal
Hypertension, Essential Hypothyroidism
Major Affective Disorder 9 Major Depressive Disorder
Parkinson Disease, Late-Onset Schizophrenia
Schizophreniform Disorder Tardive Dyskinesia

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to Bipolar Disorder

Symptoms & Phenotypes for Bipolar Disorder

GenomeRNAi Phenotypes related to Bipolar Disorder according to GeneCards Suite gene sharing:

25 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.62 IMPA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 DRD3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.62 DRD3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.62 ATP2A2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.62 DRD3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.62 DRD3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.62 DRD3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 ATP2A2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.62 ATP2A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 ATP2A2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.62 IMPA2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 ATP2A2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 ATP2A2 DRD3 IMPA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.62 ATP2A2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.62 DRD3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 DRD3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 IMPA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.62 DRD3

MGI Mouse Phenotypes related to Bipolar Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 ATP2A2 BDNF COMT DISC1 DRD3 IMPA1

Drugs & Therapeutics for Bipolar Disorder

Drugs for Bipolar Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 465)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
2
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54910-89-3 3386
3
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
4
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2 20748-11-2, 113-45-1 4158
5
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1 132539-06-1 4585
6
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1 106266-06-2 5073
7
Sertraline Approved Phase 4,Phase 3,Phase 1,Phase 2 79617-96-2 68617
8
Topiramate Approved Phase 4,Phase 3,Phase 1 97240-79-4 5284627
9
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 99-66-1 3121
10
Ziprasidone Approved Phase 4,Phase 3,Phase 2 146939-27-7 60854
11
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 298-46-4 2554
12
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
13
Acamprosate Approved, Investigational Phase 4,Phase 1,Phase 2 77337-76-9 71158
14
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
15
Coal tar Approved Phase 4,Phase 2 8007-45-2
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
17
Oxcarbazepine Approved Phase 4,Phase 2,Phase 3 28721-07-5 34312
18
Bupropion Approved Phase 4,Phase 3,Phase 1,Phase 2 34911-55-2, 34841-39-9 444
19
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
20
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
21
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
22
Citalopram Approved Phase 4,Phase 2,Phase 3,Phase 1 59729-33-8 2771
23
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 61869-08-7 43815
24
Memantine Approved, Investigational Phase 4,Phase 2,Phase 3 19982-08-2 4054
25
Nortriptyline Approved Phase 4 72-69-5 4543
26
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
27
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
28
Asenapine Approved Phase 4,Phase 3,Phase 2,Phase 1 85650-56-2, 65576-45-6 3001386
29
Pramipexole Approved, Investigational Phase 4,Phase 2 104632-26-0 119570 59868
30
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2 50-36-2 446220 5760
31
Galantamine Approved Phase 4,Phase 3 357-70-0 9651
32
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 16590-41-3 5360515
33
Clozapine Approved Phase 4,Phase 3,Phase 2 5786-21-0 2818
34
Metformin Approved Phase 4,Phase 3 657-24-9 4091 14219
35
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6, 75614-87-8 774
36
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
37
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
38
Acetylcholine Approved Phase 4 51-84-3 187
39
Cycloserine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 68-41-7 6234 401
40
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
41
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
42
Donepezil Approved Phase 4 120014-06-4 3152
43
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 2 10118-90-8 5281021
44
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
45
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
46 Racepinephrine Approved Phase 4 329-65-7
47
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
48
Dipyridamole Approved Phase 4 58-32-2 3108
49 Piracetam Approved, Investigational Phase 4,Phase 2 7491-74-9
50
Methohexital Approved Phase 4 151-83-7 9034

Interventional clinical trials:

(show top 50) (show all 1227)

# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Juvenile Bipolar Disorder Outpatient Program Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
3 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Phase 4 Mood stabilizer treatment
4 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
5 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
6 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
7 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4 Acamprosate;Placebo
8 Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder Unknown status NCT02252341 Phase 4
9 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
10 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
11 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Unknown status NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
12 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4 Tranylcypromine
13 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
14 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
15 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
16 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
17 Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
18 Reduction of Cardiovascular Risk in Severe Mental Illness Unknown status NCT01182012 Phase 4
19 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
20 Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
21 Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder Completed NCT02456896 Phase 4 Oxcarbazepine
22 Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Completed NCT02918097 Phase 4 Lithium Carbonate;Sertraline;Nortriptyline;Risperidone
23 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
24 Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder Completed NCT01864551 Phase 4 Lamotrigine;Olanzapine
25 Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder Completed NCT00667745 Phase 4 Lithium Carbonate;Optimized Treatment (OPT)
26 The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States. Completed NCT00154323 Phase 4 Oxcarbazepine
27 Comparative Effectiveness Study for Bipolar Disorder Completed NCT01331304 Phase 4 Lithium;Quetiapine
28 Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder Completed NCT00199966 Phase 4 Divalproex sodium extended release
29 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed NCT01010204 Phase 4 Varenicline;Placebo
30 Abilify in Bipolar Disorder for 6 Weeks Treatment Effectiveness Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
31 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
32 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
33 Ziprasidone in Pediatric Bipolar Disorder Completed NCT00622739 Phase 4 Ziprasidone;Ziprasidone
34 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
35 Ziprasidone Switching in Response to Adherence and Psychotropic-Related Weight Gain Concerns Among Patients With Bipolar Disorder (Zip Ad) Completed NCT01293825 Phase 4 ziprasidone
36 Asenapine in the Treatment of Older Adults With Bipolar Disorder Completed NCT01460290 Phase 4 Asenapine
37 Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
38 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole
39 Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine Completed NCT00394095 Phase 4 Topiramate;Placebo
40 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4 Quetiapine Fumarate;Lithium
41 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed NCT00360126 Phase 4 lamotrigine
42 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed NCT00280293 Phase 4 Lamotrigine;Placebo
43 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4 Galantamine-ER;Galantamine placebo
44 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
45 Lamictal As Add on Treatment in Mixed States of Bipolar Disorder Completed NCT00223509 Phase 4 Lamotrigine
46 FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder Completed NCT00596622 Phase 4 Lithium
47 Efficacy and Safety of Aripiprazole in Patients With Schizophrenia or Bipolar Disorder Completed NCT00216723 Phase 4 Aripiprazole
48 Ramelteon for the Treatment of Insomnia and Mood Stability in Patients With Euthymic Bipolar Disorder Completed NCT00552760 Phase 4 Ramelteon;Placebo
49 Geodon in Weight Loss Study for Bipolar Disorders Completed NCT00472641 Phase 4 Ziprasidone/Geodon
50 Metabolic Effects of Switching to Aripiprazole in Patients With Bipolar Disorders Completed NCT00845988 Phase 4 aripiprazole

Search NIH Clinical Center for Bipolar Disorder

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: bipolar disorder

Genetic Tests for Bipolar Disorder

Anatomical Context for Bipolar Disorder

MalaCards organs/tissues related to Bipolar Disorder:

38
Brain, Cortex, Testes, Eye, Prefrontal Cortex, Heart, Cingulate Cortex

Publications for Bipolar Disorder

Articles related to Bipolar Disorder:

(show top 50) (show all 1935)
# Title Authors Year
1
Altered frontal-amygdala effective connectivity during effortful emotion regulation in bipolar disorder. ( 29430790 )
2018
2
Case series of diagnostic shift from bipolar disorder to schizoaffective disorder. ( 29189086 )
2018
3
Morningness-Eveningness questionnaire in bipolar disorder. ( 29427910 )
2018
4
Resilience concepts in psychiatry demonstrated with bipolar disorder. ( 29423550 )
2018
5
C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis. ( 29449061 )
2018
6
Theory of mind in remitted bipolar disorder: Younger patients struggle in tasks of higher ecological validity. ( 29428351 )
2018
7
DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder. ( 29430824 )
2018
8
Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep-related differences in fronto-limbic activation patterns. ( 29441653 )
2018
9
Bipolar Disorder and Heart Transplantation: A Case Report. ( 29428124 )
2018
10
Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder. ( 29441659 )
2018
11
Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. ( 29425665 )
2018
12
Religiosity, depression, and quality of life in bipolar disorder: a two-year prospective study. ( 29451588 )
2018
13
Decreased anterior cingulate activation in a motor task in youths with bipolar disorder. ( 29451300 )
2018
14
Initiation and long-term use of benzodiazepines and Z-drugs in bipolar disorder. ( 29450954 )
2018
15
Olfactory processing in bipolar disorder, major depression, and anxiety. ( 29441710 )
2018
16
The 'new normal': relativity of quality of life judgments in individuals with bipolar disorder-a qualitative study. ( 29435800 )
2018
17
The relationship between inflammatory state and quantity of affective episodes in bipolar disorder. ( 29433074 )
2018
18
3D<sup>7</sup>Li magnetic resonance imaging of brain lithium distribution in bipolar disorder. ( 29426954 )
2018
19
Clinical staging model in offspring of parents with bipolar disorder: a systematic review. ( 29446217 )
2018
20
Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. ( 29441665 )
2018
21
ADHD-juvenile bipolar disorder: mimics and chameleons! ( 29446039 )
2018
22
Bipolar Disorder With Mixed Features Associated With Primary Hyperparathyroidism. ( 28010754 )
2017
23
The Role of Electroconvulsive Therapy (ECT) in Bipolar Disorder: Effectiveness in 522 Patients with Bipolar Depression, Mixed-state, Mania and Catatonic Features. ( 28503107 )
2017
24
Lifetime presence of psychotic symptoms in bipolar disorder is associated with less favorable socio-demographic and certain clinical features. ( 28531646 )
2017
25
Residual depressive symptoms, sleep disturbance and perceived cognitive impairment as determinants of functioning in patients with bipolar disorder. ( 28068616 )
2017
26
Levels of Cognitive Control: A Functional Magnetic Resonance Imaging-Based Test of an RDoC Domain Across Bipolar Disorder and Schizophrenia. ( 28948978 )
2017
27
The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder. ( 28144920 )
2017
28
Book review: Bipolar disorder in youth - Presentation, treatment and neurobiology Strakowski Stephen M DelBello Melissa P Adler Caleb M (eds), Bipolar disorder in youth - Presentation, treatment and neurobiology . New York, NY : Oxford University Press , 2015 . ISBN 978-0199985357 ; 382 pp., US $95.00 . ( 28504042 )
2017
29
Cost-effectiveness of structured group psychoeducation versus unstructured group support for bipolar disorder: Results from a multi-centre pragmatic randomised controlled trial. ( 28086146 )
2017
30
Hypersomnia and cognitive impairment in a patient with bipolar disorder - a case report. ( 28866718 )
2017
31
Older and Newer Strategies for the Pharmacological Treatment of Agitation in Schizophrenia and Bipolar Disorder. ( 28933260 )
2017
32
Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )
2017
33
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. ( 28941119 )
2017
34
A Multilevel Functional Study of a SNAP25 At-Risk Variant for Bipolar Disorder and Schizophrenia. ( 28972123 )
2017
35
Structural correlates of trait impulsivity in patients with bipolar disorder and healthy controls: a surface-based morphometry study. ( 28077175 )
2017
36
Adolescent-onset X-linked Adrenoleukodystrophy Presenting as Treatment-resistant Bipolar Disorder. ( 29200571 )
2017
37
Obesity and frontal-striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative. ( 28944976 )
2017
38
The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder(1). ( 27790829 )
2017
39
Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder. ( 28049082 )
2017
40
Characteristics and Service Use of Older Adults with Schizoaffective Disorder Versus Older Adults with Schizophrenia and Bipolar Disorder. ( 28478998 )
2017
41
Effects of glutathione S-transferase M1 andT1 deletions on bipolar disorder risk among a Tunisian population. ( 28043918 )
2017
42
No apparent association between bipolar disorder and cancer in a large epidemiological study of outpatients in a managed care population. ( 28938233 )
2017
43
Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using (31)P-Magnetic Resonance Spectroscopy. ( 28527566 )
2017
44
Primary cilia formation is diminished in schizophrenia and bipolar disorder: A possible marker for these psychiatric diseases. ( 28927861 )
2017
45
Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder. ( 28350397 )
2017
46
Staging in bipolar disorder: from theoretical framework to clinical utility. ( 28941093 )
2017
47
Consanguinity Associated with Increased Prevalence and Severity of Bipolar Disorder in Pakistan: A Case Report Highlighting the Genetic Link. ( 28936379 )
2017
48
Hypersomnia hiding a bipolar disorder. ( 28687972 )
2017
49
Hypersomnia: an overlooked, but not overestimated, sleep disturbance in bipolar disorder. ( 28235881 )
2017
50
Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis. ( 28291257 )
2017

Variations for Bipolar Disorder

Copy number variations for Bipolar Disorder from CNVD:

7 (show top 50) (show all 399)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13918 1 100964950 101093664 Deletion Bipolar disorder
2 13959 1 101777242 101789688 Copy number Bipolar disorder
3 14276 1 106411328 106634702 Copy number Bipolar disorder
4 15012 1 111824223 111936532 Deletion Bipolar disorder
5 15144 1 112987422 113369070 Deletion Bipolar disorder
6 15198 1 113388739 114043773 Deletion Bipolar disorder
7 15265 1 114105331 114260861 Deletion Bipolar disorder
8 15293 1 114379103 114611497 Deletion Bipolar disorder
9 15315 1 114627212 115118807 Deletion Bipolar disorder
10 17285 1 142400000 148000000 Deletion Bipolar disorder
11 17371 1 142600000 147000000 Copy number Bipolar disorder
12 17555 1 14341488 14762438 Deletion Bipolar disorder
13 18108 1 144093481 144503421 Deletion Bipolar disorder
14 21577 1 159722810 159884140 Copy number FCGR2A Bipolar disorder
15 21578 1 159722810 159884140 Copy number FCGR2C Bipolar disorder
16 21579 1 159722810 159884140 Copy number FCGR3A Bipolar disorder
17 21580 1 159722810 159884140 Copy number FCGR3B Bipolar disorder
18 21581 1 159722810 159884140 Copy number HSPA6 Bipolar disorder
19 24355 1 179082079 179207535 Deletion Bipolar disorder
20 27840 1 214001144 214182688 Deletion Bipolar disorder
21 30012 1 239069843 239226340 Deletion Bipolar disorder
22 30852 1 246404335 246667943 Deletion Bipolar disorder
23 30991 1 247034191 247138092 Deletion Bipolar disorder
24 31736 1 30336050 30952188 Deletion Bipolar disorder
25 34240 1 53925291 53984359 Copy number GLIS1 Bipolar disorder
26 35075 1 59854502 60323099 Deletion Bipolar disorder
27 35289 1 62052182 62289893 Deletion Bipolar disorder
28 35722 1 66557267 66646247 Copy number PDE4B Bipolar disorder
29 35951 1 696962 803181 Deletion Bipolar disorder
30 37047 1 84784450 84864145 Copy number CTBS Bipolar disorder
31 37048 1 84784450 84864145 Copy number SPATA1 Bipolar disorder
32 37147 1 85996510 86164671 Deletion Bipolar disorder
33 38265 10 10058972 10215130 Deletion Bipolar disorder
34 39159 10 111195021 111323778 Deletion Bipolar disorder
35 39762 10 119100000 135374737 Deletion Bipolar disorder
36 40469 10 128361479 128559816 Deletion Bipolar disorder
37 42381 10 32899498 33000799 Deletion Bipolar disorder
38 42648 10 37554667 37710375 Deletion Bipolar disorder
39 43112 10 44523027 44679489 Copy number Bipolar disorder
40 43587 10 47013328 47173619 Copy number Bipolar disorder
41 44374 10 56148428 56359760 Deletion Bipolar disorder
42 47196 10 90344868 90556337 Deletion Bipolar disorder
43 47223 10 90559662 90957411 Deletion Bipolar disorder
44 49063 11 102652001 102778728 Deletion Bipolar disorder
45 50159 11 114721884 114868905 Deletion Bipolar disorder
46 51811 11 131159857 131261275 Deletion Bipolar disorder
47 51869 11 132518807 132864395 Deletion Bipolar disorder
48 51963 11 133786141 134449982 Deletion Bipolar disorder
49 53165 11 25250128 26084796 Deletion Bipolar disorder
50 53245 11 26949271 27197653 Deletion Bipolar disorder

Expression for Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for Bipolar Disorder

GO Terms for Bipolar Disorder

Biological processes related to Bipolar Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.73 COMT DRD3 MTHFR SLC6A4
2 phosphatidylinositol phosphorylation GO:0046854 9.54 IMPA1 IMPA2 NRG1
3 phosphate-containing compound metabolic process GO:0006796 9.48 IMPA1 IMPA2
4 response to pain GO:0048265 9.46 COMT RELN
5 glial cell differentiation GO:0010001 9.4 NRG1 RELN
6 learning GO:0007612 9.33 COMT DRD3 RELN
7 dopamine metabolic process GO:0042417 9.32 COMT DRD3
8 inositol phosphate dephosphorylation GO:0046855 9.26 IMPA1 IMPA2
9 inositol metabolic process GO:0006020 8.96 IMPA1 IMPA2
10 inositol biosynthetic process GO:0006021 8.62 IMPA1 IMPA2

Molecular functions related to Bipolar Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inositol monophosphate 3-phosphatase activity GO:0052832 9.26 IMPA1 IMPA2
2 inositol monophosphate phosphatase activity GO:0052834 9.16 IMPA1 IMPA2
3 inositol monophosphate 4-phosphatase activity GO:0052833 8.96 IMPA1 IMPA2
4 inositol monophosphate 1-phosphatase activity GO:0008934 8.62 IMPA1 IMPA2

Sources for Bipolar Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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