MCID: BPL003
MIFTS: 65

Bipolar Disorder malady

Genetic diseases, Rare diseases, Mental diseases categories

Aliases & Classifications for Bipolar Disorder

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Bipolar Disorder, Aliases & Descriptions:

Name: Bipolar Disorder 30 9 41 20 11 43 32 60
Manic Depression 9 41
Manic Disorder 9 60
Manic Bipolar Affective Disorder 9
Bipolar Disorder Manic Phase 9
Manic-Depressive Psychosis 41
Major Affective Disorder 1 60
Bipolar Affective Disorder 41
Manic Depressive Disorder 9
Affective Disorder, Major 60
 
Manic Bipolar I Disorder 9
Major Affective Disorder 41
Affective Disorder Major 43
Bipolar Disorder, Mixed 60
Mixed Bipolar Disorder 9
Depression, Bipolar 60
Depression Bipolar 43
Bipolar Depression 9
Bipolar Illness 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases


Summaries for Bipolar Disorder

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MedlinePlus:32 Bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards based summary: Bipolar Disorder, also known as manic depression, is related to schizophrenia and personality disorder. An important gene associated with Bipolar Disorder is ALG9 (ALG9, alpha-1,2-mannosyltransferase), and among its related pathways are SIDS Susceptibility Pathways and Development EGFR signaling pathway. The drugs carbamazepine and clonazepam and the compounds carbidopa and mdma have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and eye, and related mouse phenotypes are taste/olfaction and muscle.

Disease Ontology:9 A mood disorder that involves alternating periods of mania and depression.

NIH Rare Diseases:41 Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia:63 Bipolar disorder, also known as bipolar affective disorder (and originally called manic-depressive... more...

Related Diseases for Bipolar Disorder

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Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia32.1DAOA, BDNF
2personality disorder31.5TPH1, SLC6A3
3attention deficit-hyperactivity disorder31.4SLC6A3, BDNF
4anxiety disorder31.4TPH1, BDNF
5substance dependence31.4SLC6A3, TPH1
6mood disorder31.1DAOA, GNAL, TPH1, RELN, NRG1, BDNF
7obsessive-compulsive disorder31.0BDNF, SLC6A3, TPH1
8eating disorder30.7BDNF, SLC6A3
9psychotic disorder30.6DAOA, TPH1, RELN, NRG1, BDNF, SLC6A3
10major depressive disorder and accelerated response to antidepressant drug treatment30.6ALG9
11anorexia nervosa30.5KCNN3, BDNF, TPH1
12neuronitis10.6
13brain disease10.5
14borderline personality disorder10.5
15bipolar i disorder10.5
16alcohol dependence10.4
17cocaine dependence10.4
18substance abuse10.4
19blindness10.4
20major affective disorder 110.4
21conduct disorder10.4
22panic disorder10.4
23dementia10.4
24paranoid schizophrenia10.4
25color blindness10.4
26major affective disorder 510.4
27major affective disorder 610.4
28major affective disorder 410.4
29thalassemia10.3
30aids dementia complex10.3BDNF, SLC6A3
31thyroiditis10.3
32neurotic disorder10.3TPH1, BDNF
33central nervous system disease10.3BDNF, GRM1, SLC6A3
34prion disease10.3SLC6A3, BDNF, NRG1
35temporal lobe epilepsy10.3BDNF, GRM1, RELN
36drug addiction10.3BDNF, SLC6A3
37trichotillomania10.3
38obesity10.3
39alcohol abuse10.3
40pervasive developmental disorder10.3
41mental retardation10.3
42mutism10.3
43parkinson disease, late-onset10.2GRM1, TPH1, BDNF, SLC6A3
44autistic disorder10.2
45autoimmune thyroiditis10.2
46cerebritis10.2
47generalized anxiety disorder10.2
48alzheimer disease10.2TPH1, RELN, SLC6A3, NRG1, BDNF
49epilepsy syndrome10.2RELN, GRM1, BDNF, SLC6A3, TPH1
50major affective disorder-710.2

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to bipolar disorder

Symptoms for Bipolar Disorder

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Drugs & Therapeutics for Bipolar Disorder

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Genetic Tests for Bipolar Disorder

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Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder20

Anatomical Context for Bipolar Disorder

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MalaCards organs/tissues related to Bipolar Disorder:

31
Brain, Cortex, Eye, Prefrontal cortex, Testes, Cingulate cortex, Amygdala, Thyroid, Cerebellum, Monocytes, Temporal lobe, Pituitary, Heart, Kidney, Skin, T cells, B lymphoblasts, Endothelial, Thalamus

Animal Models for Bipolar Disorder or affiliated genes

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MGI Mouse Phenotypes related to Bipolar Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.7SLC6A3, GNAL, BDNF, SYN2
2MP:00053699.4GRM1, RELN, SLC6A3, CIT, TPH1, NRG1
3MP:00053898.9BDNF, GRM1, NRG1, RELN, CIT, KCNN3
4MP:00053788.7RELN, PCLO, NRG1, GNAL, TPH1, GRM1
5MP:00053868.6BDNF, TPH1, CIT, RELN, SYN2, NRG1
6MP:00107688.5IMPA1, PCLO, GNAL, CIT, NRG1, GRM1
7MP:00036318.5IMPA1, CIT, RELN, PCLO, NRG1, GRM1

Publications for Bipolar Disorder

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Articles related to Bipolar Disorder:

(show top 50)    (show all 1546)
idTitleAuthorsYear
1
Does a history of substance abuse and illness chronicity predict increased impulsivity in bipolar disorder? (25863910)
2015
2
Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates. (25904869)
2015
3
An association between the use of hypnotics and quit status in the treatment of nicotine dependence with varenicline in bipolar disorder. (25627075)
2015
4
Correlates of depression in bipolar disorder. (24352942)
2014
5
Enhanced fidelity to treatment for bipolar disorder: results from a randomized controlled implementation trial. (24129806)
2014
6
Bipolar disorder - underdiagnosis and HoNOS-PbR. (23995210)
2013
7
Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder. (24119150)
2013
8
Pharmacotherapy of bipolar disorder in children and adolescents: an update. (24402215)
2013
9
Screening for Bipolar Disorder Symptoms in Depressed Primary Care Attenders: Comparison between Mood Disorder Questionnaire and Hypomania Checklist (HCL-32). (24236281)
2013
10
Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. (23044341)
2013
11
Smoking and suicidality in subjects with bipolar disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23658140)
2013
12
Child Behavior Checklist-Mania Scale (CBCL-MS): development and evaluation of a population-based screening scale for bipolar disorder. (23967059)
2013
13
Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. (23377749)
2013
14
Menstrual psychosis: presenting symptom of bipolar disorder not otherwise specified in a 13-years-old Hispanic female. (24282923)
2013
15
Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder. (23904016)
2013
16
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
17
Wearable Monitoring for Mood Recognition in Bipolar Disorder based on History-Dependent Long-Term Heart Rate Variability Analysis. (24240031)
2013
18
Self-reported creativity in bipolar disorder: prevalence, types and associated outcomes in mania versus hypomania. (24084622)
2013
19
Comorbidities and mortality in bipolar disorder: a Swedish national cohort study. (23863861)
2013
20
Bipolar disorder and interferon treatment: how to manage? (23817449)
2013
21
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. (20368704)
2011
22
Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population. (20537720)
2011
23
Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples. (21507135)
2011
24
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. (20157312)
2011
25
Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. (22085476)
2011
26
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. (19621016)
2010
27
Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism. (17895927)
2007
28
Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. (17015812)
2006
29
Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder. (16359584)
2006
30
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. (16861106)
2006
31
Effect of risperidone on plasma catecholamine metabolites and brain-derived neurotrophic factor in patients with bipolar disorders. (17029305)
2006
32
Family, twin, adoption, and molecular genetic studies of juvenile bipolar disorder. (16403185)
2005
33
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
34
MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. (15992519)
2005
35
Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. (15885920)
2005
36
Long-term observational comparison of risperidone and olanzapine in bipolar disorder. (15328900)
2004
37
Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. (15127079)
2004
38
Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. (12716249)
2003
39
Identifying bipolar disorders in individuals with intellectual disability. (12558693)
2003
40
Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders. (12890311)
2003
41
Valproate, bipolar disorder and polycystic ovarian syndrome. (12656935)
2003
42
Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder. (14604458)
2003
43
No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. (12951196)
2003
44
A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. (12097806)
2002
45
The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder. (15014728)
2002
46
Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. (11304827)
2001
47
Association studies of candidate genes in bipolar disorders. (11093065)
2000
48
Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder. (11252663)
1999
49
Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. (8935216)
1996
50
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. (8950413)
1996

Variations for Bipolar Disorder

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Expression for genes affiliated with Bipolar Disorder

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Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for genes affiliated with Bipolar Disorder

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Pathways related to Bipolar Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9BDNF, YWHAH, TPH1
2
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.9YWHAH, NRG1, BDNF
3
Show member pathways
9.8GNAL, TPH1, GRM1, SLC6A3
4
Show member pathways
9.8BDNF, SLC6A3, NDUFV2, GNAL
5
Show member pathways
9.8SLC6A3, SYN2, GNAL, KCNN3
6
Show member pathways
9.6GNAL, GRM1, NRG1, CACNG5, BDNF
7
Show member pathways
9.5BDNF, NRG1, CACNG5, GNAL, YWHAH
8
Show member pathways
9.5GNAL, BDNF, NRG1, CACNG5, YWHAH
9
Show member pathways
9.5GNAL, CIT, CACNG5, NRG1, BDNF

Compounds for genes affiliated with Bipolar Disorder

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Compounds related to Bipolar Disorder according to GeneCards Suite gene sharing:

(show all 48)
idCompoundScoreTop Affiliating Genes
1carbidopa43 2811.6TPH1, SLC6A3
2mdma4310.6SLC6A3, TPH1
3D-Myo-inositol 4-phosphate2410.5IMPA1, IMPA2
4Myo-inositol 1-phosphate2410.5IMPA2, IMPA1
5Inositol phosphate2410.5IMPA2, IMPA1
61D-myo-Inositol 3-phosphate2410.5IMPA1, IMPA2
7Myoinositol2410.5IMPA1, IMPA2
8inositol monophosphate4310.5IMPA2, IMPA1
9antidepressants4910.5BDNF, TPH1
10escitalopram43 49 24 1213.5BDNF, SLC6A3
11quisqualate43 1211.4BDNF, GRM1
12maoa4310.4TPH1, BDNF, SLC6A3
13fluvoxamine43 49 1212.4SLC6A3, BDNF, TPH1
14homovanillic acid43 2411.4BDNF, TPH1
15paroxetine43 49 28 1213.4TPH1, BDNF, SLC6A3
16alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4310.4BDNF, GRM1
17methamphetamine43 49 1212.4SLC6A3, BDNF, TPH1
18fluoxetine43 49 28 1213.4TPH1, BDNF, SLC6A3
19pilocarpine43 28 1212.4BDNF, GRM1
20pramipexole43 28 49 1213.4BDNF, SLC6A3
21citalopram43 49 24 1213.4SLC6A3, BDNF, TPH1
22levodopa43 1211.4SLC6A3, BDNF, TPH1
231 methyl 4 phenylpyridinium4310.4BDNF, SLC6A3
24venlafaxine43 49 24 1213.3BDNF, SLC6A3
25choline43 24 1212.3SLC6A3, BDNF, TPH1
26heroin43 49 1212.3SLC6A3, BDNF
27carbachol43 28 1212.2BDNF, GRM1, NRG1
28inositol4310.2BDNF, IMPA2, IMPA1
29lithium43 49 24 1213.2IMPA1, IMPA2, BDNF, TPH1
30valproate4310.2RELN, BDNF, SLC6A3, IMPA1
31acetylcholine43 49 28 24 1214.2SLC6A3, BDNF, NRG1, TPH1
32selegiline43 1211.2SLC6A3, BDNF
33proline4310.1DAOA, NRG1, GRM1, BDNF
34valine4310.1TPH1, BDNF, SLC6A3
35forskolin43 49 1212.1TPH1, NRG1, GRM1, BDNF
36potassium43 24 1212.1BDNF, GRM1, NRG1, KCNN3
37thapsigargin43 5911.1SLC6A3, BDNF, GRM1
38inositol 1,4,5 trisphosphate4310.1IMPA1, BDNF, GRM1
39nortriptyline49 43 28 1213.0BDNF, SLC6A3
40phosphoinositide4310.0RELN, NRG1, GRM1, BDNF, IMPA1
41dopamine43 28 24 1212.9DAOA, TPH1, NRG1, GRM1, BDNF, SLC6A3
42nmda43 2810.9DAOA, RELN, NRG1, GRM1, BDNF, SLC6A3
43gaba439.9SLC6A3, BDNF, GRM1, NRG1, RELN, TPH1
44ketamine43 28 1211.8SLC6A3, BDNF
45cyclic amp43 2410.8TPH1, NRG1, GRM1, BDNF
46glutamate439.8DAOA, TPH1, RELN, NRG1, GRM1, BDNF
47tyrosine439.4BDNF, GRM1, NRG1, RELN, TPH1, YWHAH
48calcium43 49 24 1212.1KCNN3, TPH1, RELN, PCLO, CACNG5, NRG1

GO Terms for genes affiliated with Bipolar Disorder

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Cellular components related to Bipolar Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.8BDNF, PCLO, SYN2

Biological processes related to Bipolar Disorder according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inositol biosynthetic processGO:000602110.3IMPA1, IMPA2
2inositol phosphate dephosphorylationGO:004685510.2IMPA1, IMPA2
3phosphatidylinositol phosphorylationGO:004685410.1IMPA1, IMPA2
4negative regulation of dendrite morphogenesisGO:005077410.1YWHAH, CIT
5dendrite developmentGO:001635810.1BDNF, RELN, CIT
6positive regulation of protein tyrosine kinase activityGO:006109810.0RELN, NRG1
7locomotory behaviorGO:000762610.0SLC6A3, GRM1, NRG1
8phosphate-containing compound metabolic processGO:00067969.8IMPA1, IMPA2
9synaptic transmissionGO:00072689.8KCNN3, GNAL, SYN2, GRM1, SLC6A3

Molecular functions related to Bipolar Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inositol monophosphate 1-phosphatase activityGO:000893410.1IMPA1, IMPA2
2inositol monophosphate 4-phosphatase activityGO:005283310.0IMPA1, IMPA2
3inositol monophosphate 3-phosphatase activityGO:00528329.8IMPA2, IMPA1
4metal ion bindingGO:00468729.4RELN, NDUFV2, GNAL, IMPA2, IMPA1, CIT

Products for genes affiliated with Bipolar Disorder

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Sources for Bipolar Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet