MCID: BPL003
MIFTS: 60

Bipolar Disorder

Categories: Rare diseases, Mental diseases, Genetic diseases

Aliases & Classifications for Bipolar Disorder

MalaCards integrated aliases for Bipolar Disorder:

Name: Bipolar Disorder 38 12 50 24 25 52 41 42 14 69
Bipolar Affective Disorder 50 25
Manic-Depressive Psychosis 50 24
Major Affective Disorder 50 69
Depression, Bipolar 25 69
Manic Depression 12 50
Manic Disorder 12 69
Manic Bipolar Affective Disorder 12
Bipolar Disorder Manic Phase 12
Bipolar Affective Psychosis 25
Major Affective Disorder 1 69
Major Affective Disorder 2 69
Manic Depressive Disorder 12
Bipolar Spectrum Disorder 25
Manic Bipolar I Disorder 12
Manic Depressive Illness 25
Affective Disorder Major 52
Depressive-Manic Psych. 12
Bipolar Disorder, Mixed 69
Mixed Bipolar Disorder 12
Bipolar Depression 12
Depression Bipolar 52
Bipolar Illness 50

Classifications:



Summaries for Bipolar Disorder

MedlinePlus : 41 bipolar disorder is a serious mental illness. people who have it go through unusual mood changes. they go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. they often have normal moods in between. the up feeling is called mania. the down feeling is depression. the causes of bipolar disorder aren't always clear. it runs in families. abnormal brain structure and function may also play a role. bipolar disorder often starts in a person's late teen or early adult years. but children and adults can have bipolar disorder too. the illness usually lasts a lifetime. if you think you may have it, tell your health care provider. a medical checkup can rule out other illnesses that might cause your mood changes. if not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. however, there are effective treatments to control symptoms: medicine and talk therapy. a combination usually works best. nih: national institute of mental health

MalaCards based summary : Bipolar Disorder, also known as bipolar affective disorder, is related to schizophrenia 9 and pervasive developmental disorder. An important gene associated with Bipolar Disorder is IMPA1 (Inositol Monophosphatase 1), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Aripiprazole and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Disease Ontology : 12 A mood disorder that involves alternating periods of mania and depression.

Genetics Home Reference : 25 Bipolar disorder is a mental health condition that causes extreme shifts in mood, energy, and behavior. This disorder most often appears in late adolescence or early adulthood, although symptoms can begin at any time of life.

NIH Rare Diseases : 50 bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). mood episodes may also include symptoms of both mania and depression (a mixed state). it often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. bipolar disorder can run in families, although no single gene is thought to cause the condition. many factors acting together likely increase a person's risk to develop the disorder. treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. last updated: 11/18/2011

Wikipedia : 72 Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of... more...

Related Diseases for Bipolar Disorder

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 9 32.3 DISC1 RGS4
2 pervasive developmental disorder 30.8 BDNF SLC6A3 SLC6A4
3 personality disorder 30.5 BDNF DISC1 DRD3 GAD1 NRG1 RELN
4 endotheliitis 30.1 BDNF TH
5 schizophrenia 29.8 ATP2A2 BDNF DAOA DISC1 DRD3 GAD1
6 major affective disorder 1 12.2
7 major affective disorder 4 11.5
8 major affective disorder-7 11.2
9 bipolar i disorder 11.2
10 mood disorder 11.1
11 schizoaffective disorder 11.1
12 major depressive disorder and accelerated response to antidepressant drug treatment 11.1
13 psychotic disorder 11.0
14 darier disease 11.0
15 obsessive-compulsive personality disorder 10.9 BDNF SLC6A4 TPH1
16 primary angle-closure glaucoma 10.9 BDNF NRG1 SLC6A4
17 keratosis 10.9 BDNF SLC6A4 TPH1
18 postencephalitic parkinson disease 10.9 BDNF SLC6A4 TPH1
19 hypoglycemic coma 10.8 BDNF SLC6A4 TPH1
20 carotid stenosis 10.8 SLC6A3 SLC6A4 TPH1
21 valproate embryopathy, susceptibility to 10.8
22 cyclothymic disorder 10.8
23 pyromania 10.8 DRD3 SLC6A3 SLC6A4
24 perinatal necrotizing enterocolitis 10.8 BDNF SLC6A3 SLC6A4
25 hepatitis d 10.8 BDNF SLC6A3 SLC6A4 TPH1
26 acute female pelvic peritonitis 10.8 DRD3 SLC6A3 SLC6A4
27 itgb4-related epidermolysis bullosa with pyloric atresia 10.8 DISC1 RELN
28 colon mucinous adenocarcinoma 10.7 BDNF DRD3 SLC6A3 SLC6A4
29 heroin dependence 10.7 BDNF DRD3 SLC6A3 SLC6A4
30 hallucinogen dependence 10.7 BDNF DRD3 SLC6A4
31 atypical autism 10.7 BDNF RELN SLC6A4
32 perry syndrome 10.7 SLC6A3 TH TPH1
33 dissociative disorder 10.7 DRD3 SLC6A4
34 alcoholic liver cirrhosis 10.7 BDNF DRD3 SLC6A4
35 cecal benign neoplasm 10.7 DRD3 SLC6A3 SLC6A4 TPH1
36 autoimmune-related retinopathy and optic neuropathy 10.7 BDNF GAD1 RELN SLC6A4
37 ovarian cystadenocarcinoma 10.7 BDNF SLC6A3 TH
38 bipolar ll disorder 10.7
39 schizophrenia 17 10.7
40 chromosome 15q13.3 microdeletion syndrome 10.7
41 schizophrenia 4 10.7
42 schizophrenia susceptibility 18 10.7
43 schizophrenia 15 10.7
44 mental retardation, x-linked, syndromic 13 10.7
45 hepatic angiomyolipoma 10.6 BDNF SLC6A3 SLC6A4 TH
46 pauci-immune glomerulonephritis with anca 10.6 BDNF DRD3 SLC6A4 TH
47 aicardi-goutieres syndrome 2 10.6 BDNF DRD3 SLC6A3 SLC6A4 TPH1
48 suppurative periapical periodontitis 10.6 DRD3 SLC6A4 TH TPH1
49 epileptic encephalopathy, early infantile, 45 10.6 BDNF DRD3 SLC6A3 SLC6A4 TPH1
50 atrial fibrillation, familial, 10 10.6 BDNF SLC6A4 TH TPH1

Comorbidity relations with Bipolar Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetes Insipidus, Nephrogenic
Hypertension, Essential Hypothyroidism
Major Affective Disorder-7 Parkinson Disease, Late-Onset
Schizophrenia Schizophreniform Disorder
Tardive Dyskinesia

Graphical network of the top 20 diseases related to Bipolar Disorder:



Diseases related to Bipolar Disorder

Symptoms & Phenotypes for Bipolar Disorder

GenomeRNAi Phenotypes related to Bipolar Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.91 IMPA2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.91 IMPA2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.91 GSK3B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.91 IMPA2 NRG1 PDLIM5 GSK3B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.91 GSK3B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.91 IMPA2 NRG1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.91 NRG1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.91 NRG1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.91 NRG1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.91 IMPA2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.91 NRG1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.91 IMPA2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.91 GSK3B
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.91 GSK3B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.62 IMPA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 DRD3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.62 DRD3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.62 ATP2A2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.62 DRD3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.62 DRD3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.62 DRD3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 ATP2A2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.62 ATP2A2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 ATP2A2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.62 IMPA2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 ATP2A2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 IMPA2 ATP2A2 DRD3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.62 ATP2A2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.62 DRD3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.62 DRD3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.62 IMPA2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.62 DRD3

MGI Mouse Phenotypes related to Bipolar Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 IMPA1 IMPA2 PDLIM5 PRODH RELN RGS4
2 growth/size/body region MP:0005378 10.28 ATP2A2 BDNF DISC1 DRD3 GAD1 GSK3B
3 homeostasis/metabolism MP:0005376 10.22 ATP2A2 BDNF DISC1 DRD3 GAD1 GSK3B
4 mortality/aging MP:0010768 10.17 GSK3B IMPA1 KCNN3 PDLIM5 RELN RGS4
5 nervous system MP:0003631 10.09 ATP2A2 BDNF DISC1 DRD3 GAD1 GSK3B
6 integument MP:0010771 10.07 ATP2A2 BDNF PRODH RELN RGS4 SLC6A3
7 digestive/alimentary MP:0005381 10 ATP2A2 BDNF DRD3 GAD1 GSK3B RELN
8 muscle MP:0005369 9.8 ATP2A2 PDLIM5 RELN SLC6A3 SLC6A4 TPH1
9 no phenotypic analysis MP:0003012 9.5 RGS4 TH BDNF GAD1 GSK3B IMPA2
10 normal MP:0002873 9.23 BDNF GAD1 GSK3B IMPA2 RGS4 SLC6A3

Drugs & Therapeutics for Bipolar Disorder

Drugs for Bipolar Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 462)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
2
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54910-89-3 3386
3
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
4
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2 113-45-1 4158
5
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1 132539-06-1 4585
6
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1 106266-06-2 5073
7
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1 79617-96-2 68617
8
Topiramate Approved Phase 4,Phase 3,Phase 1 97240-79-4 5284627
9
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 99-66-1 3121
10
Ziprasidone Approved Phase 4,Phase 3,Phase 2 146939-27-7 60854
11
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 298-46-4 2554
12
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
13
Acamprosate Approved, Investigational Phase 4,Phase 1,Phase 2 77337-76-9 71158
14
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
15
Coal tar Approved Phase 4,Phase 2 8007-45-2
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
17
Oxcarbazepine Approved Phase 4,Phase 2,Phase 3 28721-07-5 34312
18
Bupropion Approved Phase 4,Phase 3,Phase 1,Phase 2 34841-39-9, 34911-55-2 444
19
Tranylcypromine Approved Phase 4 155-09-9 441233
20
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
21
Citalopram Approved Phase 4,Phase 2,Phase 3,Phase 1 59729-33-8 2771
22
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 61869-08-7 43815
23
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
24
Memantine Approved, Investigational Phase 4,Phase 2,Phase 3 19982-08-2 4054
25
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
26
Nortriptyline Approved Phase 4 72-69-5 4543
27
Pramipexole Approved, Investigational Phase 4,Phase 2 104632-26-0 59868 119570
28
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 16590-41-3 5360515
29
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2 50-36-2 5760 446220
30
Asenapine Approved Phase 4,Phase 3,Phase 2,Phase 1 85650-56-2, 65576-45-6 3001386
31
Galantamine Approved Phase 4,Phase 3 357-70-0 9651
32
Clozapine Approved Phase 4,Phase 3,Phase 2 5786-21-0 2818
33
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
34
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 75614-87-8, 51-45-6 774
35
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
36
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
37
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
38
Acetylcholine Approved Phase 4 51-84-3 187
39
Cycloserine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 68-41-7 401 6234
40
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 6740-88-1 3821
41
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
42
Donepezil Approved Phase 4 120014-06-4 3152
43
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 2 10118-90-8 5281021
44
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
45
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
46 Racepinephrine Approved Phase 4
47
Dipyridamole Approved Phase 4 58-32-2 3108
48 Piracetam Approved Phase 4,Phase 2 7491-74-9
49
Methohexital Approved Phase 4 151-83-7 9034
50
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2 112111-43-0

Interventional clinical trials:

(show top 50) (show all 1260)

id Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4 quetiapine fumarate tablet (Seroquel)
2 Juvenile Bipolar Disorder Outpatient Program Unknown status NCT01000402 Phase 4 Psychopharmacotherapy
3 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Phase 4 Mood stabilizer treatment
4 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
5 Iloperidone in Mixed States of Bipolar Disorder Unknown status NCT02413918 Phase 4 iloperidone
6 Neural Correlates for Therapeutic Mechanisms of Lithium in Bipolar Disorder Unknown status NCT01543724 Phase 4 Lithium
7 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
8 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
9 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4 Acamprosate;Placebo
10 Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder Unknown status NCT02252341 Phase 4
11 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
12 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4 Bupropion
13 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4 Tranylcypromine
14 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4 ropinirole
15 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
16 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
17 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
18 Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4 Utapine;Seroquel
19 Reduction of Cardiovascular Risk in Severe Mental Illness Unknown status NCT01182012 Phase 4
20 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
21 Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients Unknown status NCT01710163 Phase 4 Lithium;Aripiprazole
22 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4 Aripiprazole;risperidone or paliperidone
23 Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness Completed NCT00545675 Phase 4 Abilify(aripiprazole);Depakote (divalproate)
24 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed NCT01010204 Phase 4 Varenicline (Chantix);Placebo
25 The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States. Completed NCT00154323 Phase 4 Oxcarbazepine
26 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
27 Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder Completed NCT00199966 Phase 4 Divalproex sodium extended release
28 Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder Completed NCT00667745 Phase 4 Lithium Carbonate;Optimized Treatment (OPT)
29 Aripiprazole in Late Life Bipolar Disorder Completed NCT00194038 Phase 4 Aripiprazole
30 Psychosocial Therapy Plus Maintenance Pharmacotherapy for Treating Bipolar Disorder Completed NCT00227968 Phase 4
31 Abilify in Bipolar Disorder for 6 Weeks Treatment Effectiveness Completed NCT00545142 Phase 4 Abilify(Aripiprazole);Depakote(Divalproate)
32 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
33 Comparative Effectiveness Study for Bipolar Disorder Completed NCT01331304 Phase 4 Lithium;Quetiapine
34 Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder Completed NCT01864551 Phase 4 Lamotrigine;Olanzapine
35 Ziprasidone in Pediatric Bipolar Disorder Completed NCT00622739 Phase 4 Ziprasidone;Ziprasidone
36 Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder Completed NCT02456896 Phase 4 Oxcarbazepine
37 Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Completed NCT02918097 Phase 4 Lithium Carbonate;Sertraline;Nortriptyline;Risperidone
38 Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine Completed NCT00394095 Phase 4 Topiramate;Placebo
39 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed NCT00360126 Phase 4 lamotrigine
40 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4 pramipexole
41 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4 Quetiapine Fumarate;Lithium
42 Ziprasidone Switching in Response to Adherence and Psychotropic-Related Weight Gain Concerns Among Patients With Bipolar Disorder (Zip Ad) Completed NCT01293825 Phase 4 ziprasidone
43 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
44 Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder Completed NCT01195363 Phase 4 quetiapine SR;quetiapine sr placebo
45 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed NCT00280293 Phase 4 Lamotrigine;Placebo
46 Lamictal As Add on Treatment in Mixed States of Bipolar Disorder Completed NCT00223509 Phase 4 Lamotrigine
47 Asenapine in the Treatment of Older Adults With Bipolar Disorder Completed NCT01460290 Phase 4 Asenapine
48 Efficacy and Safety of Aripiprazole in Patients With Schizophrenia or Bipolar Disorder Completed NCT00216723 Phase 4 Aripiprazole
49 Treatment and Outcome of Early Onset Bipolar Disorder Completed NCT00048802 Phase 4 Lithium;Olanzapine;Divalproex;Risperidone;Quetiapine;Ziprasidone;Aripriprazole
50 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4 Galantamine-ER;Galantamine placebo

Search NIH Clinical Center for Bipolar Disorder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bipolar disorder

Genetic Tests for Bipolar Disorder

Genetic tests related to Bipolar Disorder:

id Genetic test Affiliating Genes
1 Bipolar Disorder 24

Anatomical Context for Bipolar Disorder

MalaCards organs/tissues related to Bipolar Disorder:

39
Brain, Cortex, Testes, Eye, Heart, Prefrontal Cortex, Cingulate Cortex

Publications for Bipolar Disorder

Articles related to Bipolar Disorder:

(show top 50) (show all 1889)
id Title Authors Year
1
Characteristics and Service Use of Older Adults with Schizoaffective Disorder Versus Older Adults with Schizophrenia and Bipolar Disorder. ( 28478998 )
2017
2
Are patients with bipolar disorder and comorbid attention-deficit hyperactivity disorder more neurocognitively impaired? ( 28941032 )
2017
3
Bipolar Disorder With Mixed Features Associated With Primary Hyperparathyroidism. ( 28010754 )
2017
4
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. ( 28941119 )
2017
5
Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using (31)P-Magnetic Resonance Spectroscopy. ( 28527566 )
2017
6
Association analysis of ANK3 variants with bipolar disorder in the Korean population. ( 28079488 )
2017
7
Effects of glutathione S-transferase M1 andT1 deletions on bipolar disorder risk among a Tunisian population. ( 28043918 )
2017
8
Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder. ( 28939162 )
2017
9
The association between insomnia-related sleep disruptions and cognitive dysfunction during the inter-episode phase of bipolar disorder. ( 28088728 )
2017
10
Lifetime presence of psychotic symptoms in bipolar disorder is associated with less favorable socio-demographic and certain clinical features. ( 28531646 )
2017
11
Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. ( 28889048 )
2017
12
Trichotillomania and Bipolar Disorder. ( 28142271 )
2017
13
Outcomes for bipolar patients assessed in the French expert center network: A 2-year follow-up observational study (FondaMental Advanced Centers of Expertise for Bipolar Disorder [FACE-BD]). ( 28944553 )
2017
14
Plasma interleukin-6 in remitted early bipolar I disorder and subjects at high-risk for bipolar disorder. ( 28365164 )
2017
15
Residual depressive symptoms, sleep disturbance and perceived cognitive impairment as determinants of functioning in patients with bipolar disorder. ( 28068616 )
2017
16
The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. ( 28944987 )
2017
17
Determining if Borderline Personality Disorder and Bipolar Disorder Are Alternative Expressions of the Same Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. ( 28922592 )
2017
18
Primary cilia formation is diminished in schizophrenia and bipolar disorder: A possible marker for these psychiatric diseases. ( 28927861 )
2017
19
The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder. ( 28944443 )
2017
20
Personality traits as an endophenotype in genetic studies on suicidality in bipolar disorder. ( 27573591 )
2017
21
Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder. ( 28350397 )
2017
22
Chronic obstructive pulmonary disease associated with increased risk of bipolar disorder. ( 28528563 )
2017
23
Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder. ( 28919554 )
2017
24
Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )
2017
25
A Review of the Efficacy and Role of the Card Sort Exercise in the Treatment of Bipolar Disorder. ( 28953761 )
2017
26
Parental Reports of Prodromal Psychopathology in Pediatric Bipolar Disorder. ( 28503109 )
2017
27
One-Year Developmental Outcomes for Infants of Mothers With Bipolar Disorder. ( 28068465 )
2017
28
Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner. ( 28528241 )
2017
29
Obesity and frontal-striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative. ( 28944976 )
2017
30
Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts. ( 28867391 )
2017
31
No apparent association between bipolar disorder and cancer in a large epidemiological study of outpatients in a managed care population. ( 28938233 )
2017
32
TLR4 gene polymorphism associated with lifetime cigarette smoking in bipolar disorder. ( 28284355 )
2017
33
The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder(1). ( 27790829 )
2017
34
Risperidone Induced Granulomatous Mastitis Secondary to Hyperprolactinemia in a Non-Pregnant Woman-A Rare Case Report in a Bipolar Disorder. ( 28273980 )
2017
35
Too Fast or Too Slow? Time and Neuronal Variability in Bipolar Disorder-A Combined Theoretical and Empirical Investigation. ( 28525601 )
2017
36
Book review: Bipolar disorder in youth - Presentation, treatment and neurobiology Strakowski Stephen M DelBello Melissa P Adler Caleb M (eds), Bipolar disorder in youth - Presentation, treatment and neurobiology . New York, NY : Oxford University Press , 2015 . ISBN 978-0199985357 ; 382 pp., US $95.00 . ( 28504042 )
2017
37
A prospective study of bipolar disorder vulnerability in relation to behavioural activation, behavioural inhibition and dysregulation of the Behavioural Activation System. ( 28535407 )
2017
38
Book Review: Finding Sanity John Cade, lithium and the taming of bipolar disorder de Moore Greg Westmore Ann . Allen and Unwin , Sydney. ( 28068832 )
2017
39
The effect of premorbid intelligence on neurocognitive and psychosocial functioning in bipolar disorder. ( 28063385 )
2017
40
Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse. ( 28809856 )
2017
41
Treatment of Comorbid Bipolar Disorder Improves Disabilities and Neuropsychological Functioning in DiGeorge Syndrome: A Case Report. ( 28926351 )
2017
42
The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder. ( 28144920 )
2017
43
Blood serum concentrations of kynurenic acid in patients diagnosed with recurrent depressive disorder, depression in bipolar disorder, and schizoaffective disorder treated with electroconvulsive therapy. ( 28866716 )
2017
44
Clinical Outcomes in Children and Adolescents With Bipolar Disorder and Substance Use Disorder Comorbidity. ( 28068464 )
2017
45
Insulin-like Growth Factor Binding Protein 2 in bipolar disorder: an expression study in peripheral tissues. ( 28090803 )
2017
46
Parenting practices in middle childhood mediate the relation between growing up with a parent having bipolar disorder and offspring psychopathology from childhood into early adulthood. ( 28925351 )
2017
47
The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder. ( 27930497 )
2017
48
Hypersomnia and cognitive impairment in a patient with bipolar disorder - a case report. ( 28866718 )
2017
49
Is Toxoplasma gondii a Trigger of Bipolar Disorder? ( 28075410 )
2017
50
A meta-analysis of neurocognition in youth with familial high risk for bipolar disorder. ( 28531561 )
2017

Variations for Bipolar Disorder

Copy number variations for Bipolar Disorder from CNVD:

7 (show top 50) (show all 399)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13918 1 100964950 101093664 Deletion Bipolar disorder
2 13959 1 101777242 101789688 Copy number Bipolar disorder
3 14276 1 106411328 106634702 Copy number Bipolar disorder
4 15012 1 111824223 111936532 Deletion Bipolar disorder
5 15144 1 112987422 113369070 Deletion Bipolar disorder
6 15198 1 113388739 114043773 Deletion Bipolar disorder
7 15265 1 114105331 114260861 Deletion Bipolar disorder
8 15293 1 114379103 114611497 Deletion Bipolar disorder
9 15315 1 114627212 115118807 Deletion Bipolar disorder
10 17285 1 142400000 148000000 Deletion Bipolar disorder
11 17371 1 142600000 147000000 Copy number Bipolar disorder
12 17555 1 14341488 14762438 Deletion Bipolar disorder
13 18108 1 144093481 144503421 Deletion Bipolar disorder
14 21577 1 159722810 159884140 Copy number FCGR2A Bipolar disorder
15 21578 1 159722810 159884140 Copy number FCGR2C Bipolar disorder
16 21579 1 159722810 159884140 Copy number FCGR3A Bipolar disorder
17 21580 1 159722810 159884140 Copy number FCGR3B Bipolar disorder
18 21581 1 159722810 159884140 Copy number HSPA6 Bipolar disorder
19 24355 1 179082079 179207535 Deletion Bipolar disorder
20 27840 1 214001144 214182688 Deletion Bipolar disorder
21 30012 1 239069843 239226340 Deletion Bipolar disorder
22 30852 1 246404335 246667943 Deletion Bipolar disorder
23 30991 1 247034191 247138092 Deletion Bipolar disorder
24 31736 1 30336050 30952188 Deletion Bipolar disorder
25 34240 1 53925291 53984359 Copy number GLIS1 Bipolar disorder
26 35075 1 59854502 60323099 Deletion Bipolar disorder
27 35289 1 62052182 62289893 Deletion Bipolar disorder
28 35722 1 66557267 66646247 Copy number PDE4B Bipolar disorder
29 35951 1 696962 803181 Deletion Bipolar disorder
30 37047 1 84784450 84864145 Copy number CTBS Bipolar disorder
31 37048 1 84784450 84864145 Copy number SPATA1 Bipolar disorder
32 37147 1 85996510 86164671 Deletion Bipolar disorder
33 38265 10 10058972 10215130 Deletion Bipolar disorder
34 39159 10 111195021 111323778 Deletion Bipolar disorder
35 39762 10 119100000 135374737 Deletion Bipolar disorder
36 40469 10 128361479 128559816 Deletion Bipolar disorder
37 42381 10 32899498 33000799 Deletion Bipolar disorder
38 42648 10 37554667 37710375 Deletion Bipolar disorder
39 43112 10 44523027 44679489 Copy number Bipolar disorder
40 43587 10 47013328 47173619 Copy number Bipolar disorder
41 44374 10 56148428 56359760 Deletion Bipolar disorder
42 47196 10 90344868 90556337 Deletion Bipolar disorder
43 47223 10 90559662 90957411 Deletion Bipolar disorder
44 49063 11 102652001 102778728 Deletion Bipolar disorder
45 50159 11 114721884 114868905 Deletion Bipolar disorder
46 51811 11 131159857 131261275 Deletion Bipolar disorder
47 51869 11 132518807 132864395 Deletion Bipolar disorder
48 51963 11 133786141 134449982 Deletion Bipolar disorder
49 53165 11 25250128 26084796 Deletion Bipolar disorder
50 53245 11 26949271 27197653 Deletion Bipolar disorder

Expression for Bipolar Disorder

Search GEO for disease gene expression data for Bipolar Disorder.

Pathways for Bipolar Disorder

Pathways related to Bipolar Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.06 GAD1 GSK3B RGS4 TH TPH1
2 11.83 BDNF SLC6A4 TH TPH1
3
Show member pathways
11.65 BDNF SLC6A3 TH
4 11.45 BDNF GAD1 TH
6
Show member pathways
11.07 SLC6A3 SLC6A4 TH
7
Show member pathways
10.47 GAD1 TH TPH1

GO Terms for Bipolar Disorder

Cellular components related to Bipolar Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.35 PDLIM5 SLC6A3 SLC6A4 TH TPH1
2 axon GO:0030424 9.02 DISC1 GAD1 NRG1 SLC6A3 TH
3 cytoplasm GO:0005737 10.03 BDNF DISC1 GAD1 GSK3B IMPA1 IMPA2

Biological processes related to Bipolar Disorder according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.77 DRD3 SLC6A3 TH
2 phosphatidylinositol phosphorylation GO:0046854 9.73 IMPA1 IMPA2 NRG1
3 response to drug GO:0042493 9.72 DRD3 GAD1 SLC6A3 SLC6A4 TH
4 circadian rhythm GO:0007623 9.7 GSK3B SLC6A4 TPH1
5 learning GO:0007612 9.61 DRD3 RELN TH
6 synaptic transmission, dopaminergic GO:0001963 9.58 DRD3 TH
7 glial cell differentiation GO:0010001 9.58 NRG1 RELN
8 negative regulation of myotube differentiation GO:0010832 9.57 BDNF XBP1
9 ammonium transmembrane transport GO:0072488 9.55 SLC6A3 SLC6A4
10 prepulse inhibition GO:0060134 9.54 DRD3 SLC6A3
11 dopamine biosynthetic process GO:0042416 9.51 SLC6A3 TH
12 inositol phosphate dephosphorylation GO:0046855 9.49 IMPA1 IMPA2
13 monoamine transport GO:0015844 9.48 SLC6A3 SLC6A4
14 aromatic amino acid family metabolic process GO:0009072 9.46 TH TPH1
15 locomotory behavior GO:0007626 9.46 DRD3 NRG1 SLC6A3 TH
16 inositol metabolic process GO:0006020 9.4 IMPA1 IMPA2
17 dopamine uptake involved in synaptic transmission GO:0051583 9.37 SLC6A3 SLC6A4
18 inositol biosynthetic process GO:0006021 9.26 IMPA1 IMPA2
19 social behavior GO:0035176 9.26 DRD3 GAD1 SLC6A4 TH
20 neurotransmitter biosynthetic process GO:0042136 8.92 GAD1 SLC6A3 SLC6A4 TH

Molecular functions related to Bipolar Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.63 GAD1 PDLIM5 SLC6A3
2 neurotransmitter:sodium symporter activity GO:0005328 9.48 SLC6A3 SLC6A4
3 monoamine transmembrane transporter activity GO:0008504 9.43 SLC6A3 SLC6A4
4 inositol monophosphate 1-phosphatase activity GO:0008934 9.4 IMPA1 IMPA2
5 inositol monophosphate 4-phosphatase activity GO:0052833 9.37 IMPA1 IMPA2
6 inositol monophosphate 3-phosphatase activity GO:0052832 9.32 IMPA1 IMPA2
7 inositol monophosphate phosphatase activity GO:0052834 9.26 IMPA1 IMPA2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 9.16 TH TPH1
9 dopamine:sodium symporter activity GO:0005330 8.96 SLC6A3 SLC6A4
10 dopamine binding GO:0035240 8.8 DRD3 SLC6A3 TH

Sources for Bipolar Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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