MCID: BPL002
MIFTS: 41

Bipolar I Disorder malady

Summaries for Bipolar I Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Bipolar I disorder (BP-I; pronounced \"type one bipolar disorder\") is a bipolar spectrum disorder... more...

MalaCards: Bipolar I Disorder is related to bipolar disorder and schizoaffective disorder. An important gene associated with Bipolar I Disorder is EGR3 (early growth response 3), and among its related pathways are Metabolic States and Circadian Oscillators and Circadian rhythm pathway. The compound riboflavin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A bipolar disorder that is characterized by at least one manic or mixed episode.

Aliases & Classifications for Bipolar I Disorder

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT
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Aliases & Descriptions:

bipolar i disorder 8 10 61


External Ids:

Disease Ontology8 DOID:14042
SNOMED-CT57 49468007
ICD9CM27 296.50

Related Diseases for Bipolar I Disorder

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bipolar I Disorder:



Diseases related to bipolar i disorder

Clinical Features for Bipolar I Disorder

Drugs & Therapeutics for Bipolar I Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bipolar I Disorder

Drug clinical trials:

Search ClinicalTrials for Bipolar I Disorder

Search NIH Clinical Center for Bipolar I Disorder

Search CenterWatch for Bipolar I Disorder

Genetic Tests for Bipolar I Disorder

Anatomical Context for Bipolar I Disorder

Sources:
33MalaCards
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MalaCards organs/tissues related to Bipolar I Disorder:

33
Whole blood, Brain, Cortex, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Prefrontal cortex, Cingulate cortex, Thalamus, Amygdala, Pituitary

Animal Models for Bipolar I Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Bipolar I Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.2EGR3, CHRNA2, DBP, DAO, SLC18A1, PER1
2MP:00053869.8PER1, CSNK1E, CRY2, EGR3, NR1D1, BHLHE41

Publications for Bipolar I Disorder

Sources:
51PubMed
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Articles related to Bipolar I Disorder:

(show top 50)    (show all 616)
idTitleAuthorsYear
1
Enhanced fidelity to treatment for bipolar disorder: results from a randomized controlled implementation trial. (24129806)
2014
2
Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression. (24139811)
2014
3
Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification. (24434185)
2014
4
The impact of limbic system morphology on facial emotion recognition in bipolar I disorder and healthy controls. (23723706)
2013
5
Clozapine-induced obsessive-compulsive symptoms in bipolar disorder. (23903341)
2013
6
Comorbidity of attention-deficit/hyperactivity disorder and bipolar disorder in North Indian clinic children and adolescents. (23642982)
2013
7
Comorbidity between bipolar disorder and cluster B personality disorders as indicator of affective dysregulation and clinical severity. (24096392)
2013
8
Suicide attempts in patients with bipolar disorder tend to precede, not follow, initiation of antiepileptic drugs. (23842016)
2013
9
Iowa Gambling Task scores predict future drug use in bipolar disorder outpatients with stimulant dependence. (24012163)
2013
10
Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report. (24330408)
2013
11
Increased parental history of bipolar disorder in the United States: association with early age of onset. (24138298)
2013
12
Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder. (23977455)
2013
13
Retrospective assessment of premorbid psychopathology and cognitive impairments in bipolar disorder. (24412406)
2013
14
Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. (23158457)
2013
15
Brain-behavior biomarkers of illness and illness risk in bipolar disorder: present findings and next steps. (24246363)
2013
16
CPAP-induced mania in bipolar disorder: a case report. (23980584)
2013
17
Is increased sexual behavior a symptom of bipolar disorder in children and adolescents? (24001164)
2013
18
Iowa Gambling Task performance in euthymic bipolar I disorder: a meta-analysis and empirical study. (23219060)
2013
19
Anomalous self-experiences contribute independently to social dysfunction in the early phases of schizophrenia and psychotic bipolar disorder. (24378241)
2013
20
The T allele of the interferon-gamma +874A/T polymorphism is associated with bipolar disorder. (21728784)
2012
21
Glandular cystitis and lithium intoxication in a patient with bipolar disorder. (22796915)
2012
22
Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. (22673686)
2012
23
Impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate. (21933201)
2012
24
Impaired cognition in bipolar I disorder: the roles of the serotonin transporter and brain-derived neurotrophic factor. (22889524)
2012
25
Zonisamide-Induced Psychosis in a Patient With Bipolar Disorder and Narcolepsy. (22713527)
2012
26
Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia? (21300409)
2011
27
Diabetes insipidus secondary to combination atypical antipsychotic and lithium use in a bipolar disorder patient: a case report. (22132358)
2011
28
Obsessive compulsive disorder with bipolar mood disorder: a rare comorbidity in India. (22021961)
2011
29
Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. (21396719)
2011
30
Valproate induced hypoactive delirium in a bipolar disorder patient with psychotic features]. (20204907)
2010
31
Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population. (19851985)
2010
32
N-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. (20148871)
2010
33
Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip). (19225952)
2009
34
A variant in the reelin gene increases the risk of schizophrenia and schizoaffective disorder but not bipolar disorder. (19436241)
2009
35
Effects of age, sex, and independent life events on amygdala and nucleus accumbens volumes in child bipolar I disorder. (18990366)
2009
36
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. (19415819)
2009
37
The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. (18829872)
2008
38
Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). (18579216)
2008
39
Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study. (18837863)
2008
40
Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents. (17885571)
2007
41
Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder. (16542183)
2006
42
Reactivity to a laboratory stressor among individuals with bipolar I disorder in full or partial remission. (16866593)
2006
43
Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. (16787706)
2006
44
Validation of the Italian version of the "Mood Disorder Questionnaire" for the screening of bipolar disorders. (16042762)
2005
45
Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder. (16186633)
2005
46
Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder. (14735135)
2004
47
Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. (11673796)
2001
48
Insight is greater in mixed than in pure manic episodes of bipolar I disorder. (11434641)
2001
49
A genetic linkage study of bipolar disorder and 13 markers on chromosome 11 including the D2 dopamine receptor. (7905737)
1993
50
Cyclothymic disorder as bipolar illness. (665861)
1978

Genetic Variations for Bipolar I Disorder

Expression for genes affiliated with Bipolar I Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bipolar I Disorder

Search GEO for disease gene expression data for Bipolar I Disorder.

Pathways for genes affiliated with Bipolar I Disorder

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 30KEGG
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Pathways related to Bipolar I Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CRY2, PER1
210.3CSNK1E, NR1D1, PER1, TIMELESS
3
Hide members
10.2PER1, DBP, BHLHE41, NR1D1, CRY2, CSNK1E

Compounds for genes affiliated with Bipolar I Disorder

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Bipolar I Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1riboflavin45 11 2412.4SLC22A6, DAO

GO Terms for genes affiliated with Bipolar I Disorder

Sources:
16Gene Ontology
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Biological processes related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:07132010.4AANAT, EGR3
2circadian rhythmGO:00762310.2PER1, TIMELESS, CRY2, EGR3, NR1D1, NFIL3
3circadian regulation of gene expressionGO:03292210.1PER1, BHLHE41
4negative regulation of transcription from RNA polymerase II promoterGO:00012210.1TIMELESS, CRY2, NR1D1, NFIL3, BHLHE41, PER1

Molecular functions related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FAD bindingGO:07194910.5DAO, CRY2
2protein binding transcription factor activityGO:00098810.5PER1, CRY2
3RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00097810.4PER1, BHLHE41
4RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.4DBP, NFIL3
5E-box bindingGO:07088810.3BHLHE41, PER1
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negativeGO:00107810.1BHLHE41, NFIL3

Products for genes affiliated with Bipolar I Disorder

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Sources for Bipolar I Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet