MCID: BPL002
MIFTS: 47

Bipolar I Disorder malady

Categories: Mental diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Bipolar I Disorder

Aliases & Descriptions for Bipolar I Disorder:

Name: Bipolar I Disorder 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14042
ICD9CM 35 296.50
SNOMED-CT 64 49468007
UMLS 69 C0236773

Summaries for Bipolar I Disorder

Disease Ontology : 12 A bipolar disorder that is characterized by at least one manic or mixed episode.

MalaCards based summary : Bipolar I Disorder is related to autism spectrum disorder and personality disorder. An important gene associated with Bipolar I Disorder is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Neuroscience and Signaling in Gap Junctions. The drugs Aripiprazole and Carbamazepine have been mentioned in the context of this disorder. Affiliated tissues include amygdala, cortex and brain, and related phenotypes are behavior/neurological and muscle

Wikipedia : 71 Bipolar I disorder (BP-I; pronounced \"type one bipolar disorder\") is a bipolar spectrum disorder... more...

Related Diseases for Bipolar I Disorder

Diseases in the Bipolar Disorder family:

Bipolar Ll Disorder Bipolar I Disorder

Diseases related to Bipolar I Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 autism spectrum disorder 29.6 BDNF COMT SLC6A4
2 personality disorder 28.7 BDNF COMT DRD1 DTNBP1 HTR1A HTR2A
3 schizophrenia 28.6 BDNF COMT DAO DRD1 DTNBP1 EGR3
4 bipolar disorder 11.4
5 rhinoscleroma 10.2 COMT NRG1
6 polyneuropathy 10.2 HTR1A HTR2A
7 teratoma with malignant transformation 10.2 BDNF HTR2A
8 splenic abscess 10.2 HTR2A SLC6A4
9 antisocial personality disorder 10.2 HTR1A HTR2A
10 chondrodysplasia lethal recessive 10.2 COMT NRG1
11 nephronophthisis 13 10.2 COMT HTR2A SLC6A4
12 aryepiglottic fold cancer 10.1 HTR1A HTR2A
13 hypoglycemia 10.1 BDNF DRD1 SLC6A4
14 euthyroid sick syndrome 10.1 HTR2A SLC6A4
15 renpenning syndrome 10.1 COMT HTR1A SLC6A4
16 apperceptive agnosia 10.1 COMT HTR1A SLC6A4
17 hemochromatosis, type 2a 10.1 BDNF COMT DRD1
18 neurogenic bladder 10.1 HTR2A SLC6A4
19 pyromania 10.1 DRD1 HTR2A SLC6A4
20 adult brainstem astrocytoma 10.1 HTR1A SLC6A4
21 intrahepatic gall duct cancer 10.1 BDNF COMT HTR2A SLC6A4
22 hepatitis b reinfection following liver transplantation 10.1 HTR1A HTR2A SLC6A4
23 chagas disease 10.1 BDNF COMT HTR2A SLC6A4
24 hereditary multiple exostoses 10.1 BDNF COMT HTR2A SLC6A4
25 chronic eosinophilic pneumonia 10.1 BDNF COMT HTR1A SLC6A4
26 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.1 BDNF COMT HTR2A SLC6A4
27 giant cell reparative granuloma 10.0 COMT NRG1
28 anodontia 10.0 HTR1A HTR2C SLC6A4
29 hypoglycemic coma 10.0 BDNF HTR1A HTR2A SLC6A4
30 postencephalitic parkinson disease 10.0 BDNF HTR1A HTR2A SLC6A4
31 cholesteatoma 10.0 BDNF COMT HTR2C SLC6A4
32 lichen disease 10.0 COMT HTR1A HTR2A SLC6A4
33 fechtner syndrome 10.0 COMT HTR1A HTR2A SLC6A4
34 anxiety disorder 10.0
35 atrial fibrillation, familial, 10 10.0 BDNF HTR1A HTR2A SLC6A4
36 cytomegalic congenital adrenal hypoplasia 9.9 BDNF COMT DRD1 HTR2A SLC6A4
37 paraphilia disorder 9.9 BDNF COMT DRD1 HTR2A SLC6A4
38 hepatitis d 9.9 BDNF COMT HTR1A HTR2A SLC6A4
39 dry eye syndrome 9.9 HTR1A HTR2A HTR2C SLC6A4
40 waardenburg's syndrome 9.9 HTR1A HTR2A HTR2C SLC6A4
41 obesity 9.9
42 attention deficit-hyperactivity disorder 9.9
43 epithelioid type angiomyolipoma 9.9 BDNF HTR2A SLC6A4
44 microcephaly 13, primary, autosomal recessive 9.9 HTR1A HTR2A HTR2C SLC6A4
45 obsessive-compulsive disorder 9.8
46 cecal benign neoplasm 9.8 COMT HTR1A HTR2A HTR2C SLC6A4
47 alzheimer disease 17 9.8 HTR1A HTR2A HTR2C PER3 SLC6A4
48 mood disorder 9.7
49 cerebritis 9.7
50 neuronitis 9.7

Graphical network of the top 20 diseases related to Bipolar I Disorder:



Diseases related to Bipolar I Disorder

Symptoms & Phenotypes for Bipolar I Disorder

MGI Mouse Phenotypes related to Bipolar I Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 HTR1A HTR2A HTR2C PER3 SLC6A4 BDNF
2 muscle MP:0005369 9.43 DRD1 DTNBP1 EGR3 HTR2A HTR2C SLC6A4
3 nervous system MP:0003631 9.36 BDNF COMT DAO DRD1 DTNBP1 EGR3

Drugs & Therapeutics for Bipolar I Disorder

Drugs for Bipolar I Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
2
Carbamazepine Approved, Investigational Phase 4,Phase 3,Phase 1 298-46-4 2554
3
Coal tar Approved Phase 4 8007-45-2
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
5
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 1 132539-06-1 4585
6
Oxcarbazepine Approved Phase 4 28721-07-5 34312
7
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 99-66-1 3121
8
Ziprasidone Approved Phase 4,Phase 3,Phase 2 146939-27-7 60854
9
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 5095 497540
10
Tranylcypromine Approved Phase 4 155-09-9 441233
11
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
12
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 6740-88-1 3821
13
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 1 106266-06-2 5073
14
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
15
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
16
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
17
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
18
Infliximab Approved Phase 4,Phase 2 170277-31-3
19
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
20
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
21
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
22
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
23
Topiramate Approved Phase 4,Phase 3 97240-79-4 5284627
24
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
25
Cycloserine Approved Phase 4,Phase 3 68-41-7 401 6234
26
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
27
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
28
Loxapine Approved Phase 4,Phase 3 1977-10-2 3964
29
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
30
Haloperidol Approved Phase 4,Phase 3,Phase 2 52-86-8 3559
31
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
32
Amphetamine Approved, Illicit Phase 4 300-62-9 5826 3007
33
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
34
Zonisamide Approved, Investigational Phase 4 68291-97-4 5734
35
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 26757 5195
36 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
37
Choline Approved, Nutraceutical Phase 4 62-49-7 305
38
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
39
Creatine Approved, Nutraceutical Phase 4 57-00-1 586
40
decanoic acid Experimental Phase 4,Phase 3,Phase 2 334-48-5 2969
41 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Antimanic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Lithium carbonate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 554-13-2
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Quetiapine Fumarate Phase 4,Phase 3,Phase 2,Phase 1 111974-72-2
49 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 465)
id Name Status NCT ID Phase
1 Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients Unknown status NCT01710163 Phase 4
2 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4
3 Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania Unknown status NCT01043679 Phase 4
4 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression. Unknown status NCT00335205 Phase 4
5 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4
6 A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder Unknown status NCT00837343 Phase 4
7 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4
8 Algorithm Guided Treatment Strategies for Bipolar Depression Unknown status NCT01938859 Phase 4
9 Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder Completed NCT00034580 Phase 4
10 A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode Completed NCT00277212 Phase 4
11 Citicoline for Bipolar 1 Disorder and Cocaine Dependence Completed NCT00619723 Phase 4
12 A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients Completed NCT00402324 Phase 4
13 The Assessment of a Weight-Gain Agent for the Treatment of Olanzapine-Associated Anti-Obesity Agent in Patients With Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, and Bipolar I Disorder Completed NCT00044187 Phase 4
14 The Young Adult and Pediatric Bipolar Study Completed NCT00350857 Phase 4
15 Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder Completed NCT00050206 Phase 4
16 Study in Adolescents With Schizophrenia or Bipolar Disorder Completed NCT00982020 Phase 4
17 Olanzapine vs. Comparator and Placebo in the Treatment of Patients With Bipolar I Disorder Completed NCT00094549 Phase 4
18 Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder Completed NCT00178061 Phase 4
19 Efficacy of Combined Treatment for Young Bipolar I Disorder Completed NCT00976794 Phase 4
20 Olanzapine Plus Carbamazepine in the Treatment of Bipolar I Mania Completed NCT00190892 Phase 4
21 Open Label Extension Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar I Disorder Completed NCT00139594 Phase 4
22 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4
23 A Study for Assessing Treatment of Patients Ages 10-17 With Bipolar Depression Completed NCT00844857 Phase 4
24 Sequential Multiple Assignment Treatment for Bipolar Disorder Completed NCT01588457 Phase 4
25 Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations Completed NCT01181960 Phase 4
26 ABLE: Abilify in Bipolar Disorder for Long-term Effectiveness Completed NCT00484471 Phase 4
27 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4
28 Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder Completed NCT00181870 Phase 4
29 Concerta in the Treatment of ADHD in Youth and Adults With Bipolar Disorder Completed NCT00181987 Phase 4
30 Study of Depakote ER for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder Completed NCT00181727 Phase 4
31 Aripiprazole for the Treatment of Mania in Children and Adolescents With Bipolar Disorder Completed NCT00181779 Phase 4
32 Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder Completed NCT00181844 Phase 4
33 A Study of Infliximab for Treatment Resistant Major Depression Completed NCT00463580 Phase 4
34 VALID : VAlproate Versus LIthium in Bipolar Disorders Completed NCT00264173 Phase 4
35 Venlafaxine Versus Lamotrigine in the Treatment of Bipolar I/II Depression Completed NCT00188643 Phase 4
36 Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression Completed NCT01303601 Phase 4
37 Olanzapine/Fluoxetine Combination Versus Comparator in the Treatment of Bipolar I Depression Completed NCT00485771 Phase 4
38 Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder Completed NCT00182013 Phase 4
39 Comparing Compliance, Tolerability, Efficacy and Adverse Events in Bipolar Tients From Valproic Acid to Depakote ER Completed NCT00211250 Phase 4
40 Gulf Evaluation of VAlproate (Depakine Chrono) in maNia Study Completed NCT00477373 Phase 4
41 The Efficacy and Safety of Oral Oxcarbazepine 300-1200 mg/Day as Adjuvant Therapy in the Treatment of Bipolar Disorder I or II This Study is Not Being Conducted in the United States. Completed NCT00154323 Phase 4
42 Optimal Length of Treatment Continuation With Olanzapine After Remission of Manic or Mixed Episode Completed NCT00191997 Phase 4
43 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed NCT01010204 Phase 4
44 Cognitive Enhancement in Bipolar Disorder Completed NCT00597896 Phase 4
45 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4
46 Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder Completed NCT00181935 Phase 4
47 Functional and Neurochemical Brain Changes in First-episode Bipolar Mania Completed NCT00609193 Phase 4
48 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4
49 A Preliminary Study of the Effectiveness and Tolerability of Aripiprazole in Bipolar Depression Completed NCT00363337 Phase 4
50 Antidepressant Therapy in Treating Bipolar Type II Major Depression Completed NCT00602537 Phase 4

Search NIH Clinical Center for Bipolar I Disorder

Genetic Tests for Bipolar I Disorder

Anatomical Context for Bipolar I Disorder

MalaCards organs/tissues related to Bipolar I Disorder:

39
Amygdala, Cortex, Brain, Testes, B Lymphoblasts, Prefrontal Cortex, Cingulate Cortex

Publications for Bipolar I Disorder

Articles related to Bipolar I Disorder:

(show top 50) (show all 616)
id Title Authors Year
1
Epidemiology of DSM-5 bipolar I disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions - III. ( 27814503 )
2017
2
Effectiveness of the Dader Method for Pharmaceutical Care on Patients with Bipolar I Disorder: Results from the EMDADER-TAB Study. ( 28025928 )
2017
3
Bipolar I disorder in remission vs. schizophrenia in remission: Is there a difference in burden? ( 27816846 )
2017
4
Autistic and schizotypal traits and global functioning in bipolar I disorder. ( 27736738 )
2017
5
Long-term safety and tolerability of asenapine: A double-blind, uncontrolled, long-term extension trial in adults with an acute manic or mixed episode associated with bipolar I disorder. ( 27755982 )
2017
6
Increased cooperative behavior across remitted bipolar I disorder and major depression: Insights utilizing a behavioral economic trust game. ( 27868424 )
2017
7
Facial emotion labeling in unaffected offspring of adults with bipolar I disorder. ( 27792963 )
2017
8
Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study. ( 27207914 )
2016
9
Safety and effectiveness of divalproex sodium extended release containing regimen in Indian patients with bipolar I disorder in continuation phase: Results of EASED registry. ( 27025469 )
2016
10
A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree. ( 27867939 )
2016
11
A pilot study of a combined group and individual functional remediation program for patients with bipolar I disorder. ( 26800305 )
2016
12
Neurological soft signs and cognitive functions: Amongst euthymic bipolar I disorder cases, non-affected first degree relatives and healthy controls. ( 27520894 )
2016
13
History of Lifetime suicide attempt in bipolar I disorder: its correlates and effect on illness course. ( 27854557 )
2016
14
Cabergoline can induce mania with psychotic features in bipolar I disorder: a case report. ( 27520906 )
2016
15
Hippocampal subfield volumes in short- and long-term lithium-treated patients with bipolar I disorder. ( 27237705 )
2016
16
Pain-processing abnormalities in bipolar I disorder, bipolar II disorder, and schizophrenia: A novel trait marker for psychosis proneness and functional outcome? ( 27782355 )
2016
17
History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first-treatment bipolar I disorder. ( 26990158 )
2016
18
Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. ( 27406927 )
2016
19
Emotion-relevant impulsivity predicts sustained anger and aggression after remission in bipolar I disorder. ( 26437231 )
2016
20
Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression. ( 26973704 )
2016
21
Sleep in Adolescents With Bipolar I Disorder: Stability and Relation to Symptom Change. ( 27472039 )
2016
22
Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. ( 27990494 )
2016
23
Unseen positive and negative affective information influences social perception in bipolar I disorder and healthy adults. ( 26745436 )
2016
24
Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first-episode mania and association with clinical outcome. ( 27759214 )
2016
25
Borderline personality disorder, but not euthymic bipolar I disorder, is associated with prolonged post-error slowing in sensorimotor performance. ( 27016660 )
2016
26
The T Allele of MTHFR c.C677T and Its Synergism with G (Val 158) Allele of COMT c.G472A Polymorphism Are Associated with the Risk of Bipolar I Disorder. ( 27447284 )
2016
27
Lithium prophylaxis during pregnancy and the postpartum period in women with lithium-responsive bipolar I disorder. ( 26790685 )
2016
28
Long-term risk of myocardial infarction and stroke in bipolar I disorder: A population-based Cohort Study. ( 26820761 )
2016
29
Neuropsychological study of IQ scores in offspring of parents with bipolar I disorder. ( 27855540 )
2016
30
Feasibility of a psychoeducational family intervention for people with bipolar I disorder and their relatives: Results from an Italian real-world multicentre study. ( 26590513 )
2016
31
Relationship Between Temperament and Character Traits, Mood, and Medications in Bipolar I Disorder. ( 27733949 )
2016
32
Cariprazine (Vraylar) for schizophrenia and bipolar I disorder. ( 27101209 )
2016
33
Admission-Based Prevalence of Schizophrenia, Schizoaffective Disorder and Bipolar I Disorder in a Catchment Area in Sinop, Turkey. ( 27711935 )
2016
34
Incidence, characteristics and course of narrow phenotype paediatric bipolar I disorder in the British Isles. ( 27744649 )
2016
35
Dysfunctional decision-making related to white matter alterations in bipolar I disorder. ( 26803778 )
2016
36
Predominant mania course in Indian patients with bipolar I disorder. ( 27520890 )
2016
37
Non-Compliance and Related Factors in Patients With Bipolar I Disorder: A Six Month Follow-Up Study. ( 27803718 )
2016
38
Cytokines, brain-derived neurotrophic factor and C-reactive protein in bipolar I disorder - Results from a prospective study. ( 26994434 )
2016
39
Perceptions of social dominance through facial emotion expressions in euthymic patients with bipolar I disorder. ( 26995253 )
2016
40
The Burden of Repeated Mood Episodes in Bipolar I Disorder: Results From the National Epidemiological Survey on Alcohol and Related Conditions. ( 26588078 )
2016
41
Duration of untreated illness in first-treatment bipolar I disorder in relation to clinical outcome and cannabis use. ( 27814886 )
2016
42
Is history of suicidal behavior related to social support and quality of life in outpatients with bipolar I disorder? ( 28029441 )
2016
43
Long-term Safety of Asenapine in Pediatric Patients Diagnosed With Bipolar I Disorder: A 50-Week Open-Label, Flexible-Dose Trial. ( 27461426 )
2016
44
Clinical outcomes of long-acting injectable risperidone in patients with bipolar I disorder: A 1-year retrospective cohort study. ( 27568173 )
2016
45
Data-driven classification of bipolar I disorder from longitudinal course of mood. ( 27727242 )
2016
46
Increased DNA and RNA damage by oxidation in patients with bipolar I disorder. ( 27505230 )
2016
47
Emotional intelligence and non-social cognition in schizophrenia and bipolar I disorder. ( 27640523 )
2016
48
Demographic and clinical characteristics associated with comorbid cannabis use disorders (CUDs) in hospitalized patients with bipolar I disorder. ( 26773991 )
2016
49
Levels of mania and cognitive performance two years after ECT in patients with bipolar I disorder - results from a follow-up study. ( 27423347 )
2016
50
Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder. ( 27280013 )
2016

Variations for Bipolar I Disorder

Expression for Bipolar I Disorder

Search GEO for disease gene expression data for Bipolar I Disorder.

Pathways for Bipolar I Disorder

GO Terms for Bipolar I Disorder

Cellular components related to Bipolar I Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 DRD1 HTR1A HTR2A HTR2C NRG1 SLC6A4
2 axon GO:0030424 8.92 COMT DTNBP1 HTR2A NRG1

Biological processes related to Bipolar I Disorder according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.85 DRD1 DTNBP1 NRG1 SLC6A4
2 response to drug GO:0042493 9.72 COMT DRD1 HTR2A HTR2C SLC6A4
3 locomotory behavior GO:0007626 9.7 DRD1 HTR2C NRG1
4 circadian rhythm GO:0007623 9.69 EGR3 PER3 SLC6A4
5 memory GO:0007613 9.63 DRD1 HTR2A SLC6A4
6 synapse assembly GO:0007416 9.61 BDNF DRD1 NRG1
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.6 DRD1 HTR2C
8 peripheral nervous system development GO:0007422 9.59 EGR3 NRG1
9 regulation of dopamine secretion GO:0014059 9.58 DTNBP1 HTR2A
10 temperature homeostasis GO:0001659 9.58 DRD1 HTR2A
11 behavioral response to cocaine GO:0048148 9.57 DRD1 HTR2A
12 vasoconstriction GO:0042310 9.56 HTR1A SLC6A4
13 dopamine metabolic process GO:0042417 9.54 COMT DRD1
14 regulation of dopamine metabolic process GO:0042053 9.49 DRD1 HTR1A
15 regulation of behavior GO:0050795 9.48 HTR1A HTR2A
16 behavioral fear response GO:0001662 9.43 DRD1 HTR1A HTR2C
17 regulation of hormone secretion GO:0046883 9.4 HTR1A HTR2A
18 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.37 HTR2A HTR2C
19 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2A HTR2C
20 behavior GO:0007610 9.13 HTR1A HTR2A HTR2C
21 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2A HTR2C

Molecular functions related to Bipolar I Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.62 DRD1 HTR1A HTR2A HTR2C
2 G-protein coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR2C
3 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.26 HTR2A HTR2C
4 neurotransmitter receptor activity GO:0030594 9.13 HTR1A HTR2A HTR2C
5 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR2C

Sources for Bipolar I Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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