MCID: BPL002
MIFTS: 38

Bipolar I Disorder malady

Genetic diseases, Mental diseases, Rare diseases categories
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Summaries for Bipolar I Disorder

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Bipolar I disorder (BP-I; pronounced \"type one bipolar disorder\") is a bipolar spectrum disorder... more...

MalaCards: Bipolar I Disorder is related to schizophrenia and blindness. An important gene associated with Bipolar I Disorder is SP8 (Sp8 transcription factor). The compound nicotine have been mentioned in the context of this disorder. Affiliated tissues include cortex, amygdala and cingulate cortex, and related mouse phenotype nervous system.

Disease Ontology:8 A bipolar disorder that is characterized by at least one manic or mixed episode.

Aliases & Classifications for Bipolar I Disorder

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases


Aliases & Descriptions:

bipolar i disorder 8 10 62


External Ids:

Disease Ontology8 DOID:14042
SNOMED-CT58 49468007
ICD9CM27 296.50

Related Diseases for Bipolar I Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bipolar I Disorder:



Diseases related to bipolar i disorder

Symptoms for Bipolar I Disorder

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Drugs & Therapeutics for Bipolar I Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Bipolar I Disorder

Search NIH Clinical Center for Bipolar I Disorder

Genetic Tests for Bipolar I Disorder

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Anatomical Context for Bipolar I Disorder

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Sources:
33MalaCards
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MalaCards organs/tissues related to Bipolar I Disorder:

33
Cortex, Amygdala, Cingulate cortex, Testes, Prefrontal cortex, B lymphoblasts, Bone marrow, Monocytes, Brain, Bone, Pituitary

Animal Models for Bipolar I Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Bipolar I Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8EGR3, AANAT, CHRNA2, ATN1, SP8

Publications for Bipolar I Disorder

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Sources:
52PubMed
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Articles related to Bipolar I Disorder:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Asenapine treatment and health-related quality of life in patients experiencing bipolar I disorder with mixed episodes: post-hoc analyses of pivotal trials. (24329543)
2014
2
Aripiprazole: A Review of Its Use in the Treatment of Manic Episodes in Adolescents with Bipolar I Disorder. (24399490)
2014
3
The impact of limbic system morphology on facial emotion recognition in bipolar I disorder and healthy controls. (23723706)
2013
4
Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients. (23837831)
2013
5
Aripiprazole-associated acute dystonia, akathisia, and parkinsonism in a patient with bipolar I disorder. (23422384)
2013
6
High insulin-like growth factor-1 in patients with bipolar I disorder: a trait marker? (24012102)
2013
7
Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder. (23449001)
2013
8
Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia. (23672587)
2013
9
Aripiprazole for the treatment and prevention of acute manic and mixed episodes in bipolar i disorder in children and adolescents: a NICE single technology appraisal. (24092620)
2013
10
Important achievements in the search for psychopathological predictors, but still a long road ahead: editorial comment to Baldessarini RJ, Undurraga J, Vazquez GH et al. 'Predominant recurrence polarity among 928 adult international bipolar-I-disorder patients' (3). (22404205)
2012
11
Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. (22938166)
2012
12
Electroconvulsive therapy in an adolescent with autism and bipolar I disorder. (22801298)
2012
13
Efficacy and safety of olanzapine in the treatment of Japanese patients with bipolar I disorder in a current manic or mixed episode: a randomized, double-blind, placebo- and haloperidol-controlled study. (22134043)
2012
14
Elevated left mid-frontal cortical activity prospectively predicts conversion to bipolar I disorder. (22775582)
2012
15
COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes. (22222175)
2012
16
Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study. (22329475)
2012
17
Antidepressant-associated mania or hypomania: a comparison with personality and bipolarity features of bipolar I disorder. (21632117)
2011
18
Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia? (21300409)
2011
19
Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials. (21689438)
2011
20
Olanzapine-induced weight gain in patients with bipolar I disorder: a meta-analysis. (22454806)
2011
21
Voxel-based morphometric analysis on the volume of gray matter in bipolar I disorder. (21236649)
2011
22
Predictors of medication nonadherence and hospitalization in Medicaid patients with bipolar I disorder given long-acting or oral antipsychotics. (21370989)
2011
23
The effect of processing speed on cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives. (21042040)
2011
24
Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. (20712758)
2010
25
Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder. (19766321)
2010
26
Treatment with aripiprazole for hyperprolactinemia induced by pituitary microadenoma in a bipolar I disorder patient. (20075655)
2010
27
Risperidone long-acting injection as monotherapy and adjunctive therapy in the maintenance treatment of bipolar I disorder. (20486830)
2010
28
Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo. (19689918)
2009
29
Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups. (19062104)
2009
30
Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. (19851515)
2009
31
Neuropsychological status of bipolar I disorder: impact of psychosis. (19252155)
2009
32
Memory functioning in familial bipolar I disorder patients and their relatives. (19267704)
2009
33
The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. (18829872)
2008
34
Demographic and clinical features of panic disorder comorbid with bipolar I disorder: a 3-year retrospective study. (17604118)
2008
35
Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients. (18837869)
2008
36
Impaired endoplasmic reticulum stress response in B-lymphoblasts from patients with bipolar-I disorder. (17217928)
2007
37
Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions. (17915973)
2007
38
Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. (17960961)
2007
39
Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder. (17136449)
2007
40
Family history of psychiatric disorders and alcohol and substance misuse in patients with bipolar I disorder, substance use disorder, or both. (17612828)
2007
41
Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. (16936705)
2006
42
"I won't do what you tell me!": elevated mood and the assessment of advice-taking in euthymic bipolar I disorder. (16487480)
2006
43
Common variations in ALG9 are not associated with bipolar I disorder: a family-based study. (16859551)
2006
44
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity and treatment outcome. (15786484)
2005
45
Acute treatment outcomes in patients with bipolar I disorder and co-morbid borderline personality disorder receiving medication and psychotherapy. (15762861)
2005
46
Use of olanzapine in the treatment of bipolar I disorder. (15853503)
2004
47
Correlates of insight among patients with bipolar I disorder in remission. (14672797)
2004
48
Suicide attempts and ideation in patients with bipolar I disorder. (15119913)
2004
49
Frequency of hospitalisations and inpatient care costs of manic episodes: in patients with bipolar I disorder in France. (14596627)
2003
50
Olanzapine: a review of its use in the treatment of bipolar I disorder. (11700151)
2001

Variations for Bipolar I Disorder

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Expression for genes affiliated with Bipolar I Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bipolar I Disorder

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Pathways for genes affiliated with Bipolar I Disorder

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Compounds for genes affiliated with Bipolar I Disorder

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank
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Compounds related to Bipolar I Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nicotine45 29 51 1112.5ANKK1, CHRNA2

GO Terms for genes affiliated with Bipolar I Disorder

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16Gene Ontology
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Biological processes related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1circadian rhythmGO:0076239.5EGR3, AANAT
2cellular response to cAMPGO:0713209.2EGR3, AANAT

Products for genes affiliated with Bipolar I Disorder

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  • Antibodies
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  • Antibodies

Sources for Bipolar I Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet