MCID: BPL002
MIFTS: 41

Bipolar I Disorder malady

Summaries for Bipolar I Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Bipolar I disorder (BP-I; pronounced \"type one bipolar disorder\") is a bipolar spectrum disorder... more...

MalaCards: Bipolar I Disorder is related to bipolar disorder and schizophrenia. An important gene associated with Bipolar I Disorder is EGR3 (early growth response 3), and among its related pathways are Metabolic States and Circadian Oscillators and Circadian rhythm pathway. The compound riboflavin have been mentioned in the context of this disorder. Affiliated tissues include cortex, amygdala and prefrontal cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A bipolar disorder that is characterized by at least one manic or mixed episode.

Aliases & Classifications for Bipolar I Disorder

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

bipolar i disorder 8 10 60


External Ids:

Disease Ontology8 DOID:14042
SNOMED-CT56 49468007
ICD9CM27 296.50

Related Diseases for Bipolar I Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bipolar I Disorder:



Diseases related to bipolar i disorder

Clinical Features for Bipolar I Disorder

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Drugs & Therapeutics for Bipolar I Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bipolar I Disorder

Drug clinical trials:

Search ClinicalTrials for Bipolar I Disorder

Search NIH Clinical Center for Bipolar I Disorder

Search CenterWatch for Bipolar I Disorder

Genetic Tests for Bipolar I Disorder

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Anatomical Context for Bipolar I Disorder

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32MalaCards
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MalaCards organs/tissues related to Bipolar I Disorder:

32
Cortex, Amygdala, Prefrontal cortex, Brain, Cingulate cortex, Testes, B lymphoblasts, Bone marrow, Monocytes, Cerebellum, Bone, Pituitary

Animal Models for Bipolar I Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Bipolar I Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.2EGR3, CHRNA2, DBP, DAO, SLC18A1, PER1
2MP:00053869.8PER1, CSNK1E, CRY2, EGR3, NR1D1, BHLHE41

Publications for Bipolar I Disorder

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50PubMed
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Articles related to Bipolar I Disorder:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Real-world emotion? An experience-sampling approach to emotion experience and regulation in bipolar I disorder. (24364600)
2013
2
Mood congruence phenomenon in acutely symptomatic mania bipolar I disorder patients with and without psychotic symptoms. (23189939)
2013
3
Recognition of bipolar disorder type I before the first manic episode: challenges and developments. (23898851)
2013
4
Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder. (23072837)
2013
5
Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. (22980587)
2013
6
Concordance between patient and family reports of family functioning in bipolar I disorder and major depressive disorder. (23588224)
2013
7
Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. (22938166)
2012
8
A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. (22420593)
2012
9
Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles. (21798721)
2012
10
Successful and rapid response to electroconvulsive therapy of a suicidal patient with comorbid bipolar I disorder and histrionic personality disorder. (22343582)
2012
11
Treatment and outcomes of an Australian cohort of outpatients with bipolar I or schizoaffective disorder over twenty-four months: implications for clinical practice. (23244301)
2012
12
Effect of variation in diacylglycerol kinase I^ (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder. (22048461)
2012
13
Information processing in adolescents with bipolar I disorder. (22390273)
2012
14
Olanzapine-induced weight gain in patients with bipolar I disorder: a meta-analysis. (22454806)
2011
15
Facial emotion recognition and its relationship to subjective and functional outcomes in remitted patients with bipolar I disorder. (22017222)
2011
16
Genetic association of bipolar disorder with the I^(3) nicotinic receptor subunit gene. (21191315)
2011
17
Young mania rating scale line item analysis in pediatric subjects with bipolar I disorder treated with aripiprazole in a short-term, double-blind, randomized study. (21823911)
2011
18
The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder. (21654871)
2011
19
Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind maintenance trial. (22134973)
2011
20
Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. (20712758)
2010
21
Risperidone long-acting injection as monotherapy and adjunctive therapy in the maintenance treatment of bipolar I disorder. (20486830)
2010
22
Risperidone long-acting injection: in bipolar I disorder. (20481656)
2010
23
Lithium treatment effects on the neuropsychological functioning of patients with bipolar I disorder. (20361895)
2010
24
Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. (20368511)
2010
25
Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients. (18837869)
2008
26
Dysregulation of the behavioral activation system in remitted bipolar I disorder. (19025230)
2008
27
Relationship between insight and neurocognition in patients with bipolar I disorder in remission. (18555052)
2008
28
Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder. (18207705)
2008
29
Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression. (18989376)
2008
30
Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. (18838629)
2008
31
Aripiprazole monotherapy in patients with rapid-cycling bipolar I disorder: an analysis from a long-term, double-blind, placebo-controlled study. (18373615)
2008
32
Safety of carbamazepine extended-release capsules used in combination with other psychotropic medications for the treatment of bipolar I disorder. (19727252)
2008
33
Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. (17960961)
2007
34
The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function. (17547582)
2007
35
Cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives. (17181912)
2007
36
Effectiveness and weight effects of open-label lamotrigine with and without concomitant psychotropic medications in patients with bipolar I disorder. (17955096)
2007
37
Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. (16936705)
2006
38
Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. (16816224)
2006
39
Family functioning and mood disorders: a comparison between patients with major depressive disorder and bipolar I disorder. (17154748)
2006
40
Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials. (17196051)
2006
41
N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder. (16165270)
2006
42
Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed. (15841678)
2005
43
Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder. (16162082)
2005
44
Controlled study of encopresis and enuresis in children with a prepubertal and early adolescent bipolar-I disorder phenotype. (16175110)
2005
45
Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (16380905)
2005
46
Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression. (16199852)
2005
47
Melatonin sensitivity to light in monozygotic twins discordant for bipolar I disorder. (16168024)
2005
48
Monocyte chemoattractant protein-1 promoter -2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population. (15034225)
2004
49
Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorder. (15679202)
2004
50
Comorbidity of anxiety disorder among patients with bipolar I disorder in remission. (12239436)
2002

Genetic Variations for Bipolar I Disorder

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Expression for genes affiliated with Bipolar I Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bipolar I Disorder

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Pathways for genes affiliated with Bipolar I Disorder

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Bipolar I Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PER1, CRY2
210.3TIMELESS, CSNK1E, NR1D1, PER1
3
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10.2PER1, DBP, BHLHE41, NR1D1, CRY2, CSNK1E

Compounds for genes affiliated with Bipolar I Disorder

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Bipolar I Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1riboflavin44 11 2412.4SLC22A6, DAO

GO Terms for genes affiliated with Bipolar I Disorder

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16Gene Ontology
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Biological processes related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:07132010.4AANAT, EGR3
2circadian rhythmGO:00762310.2PER1, TIMELESS, CRY2, EGR3, NR1D1, NFIL3
3circadian regulation of gene expressionGO:03292210.1PER1, BHLHE41
4negative regulation of transcription from RNA polymerase II promoterGO:00012210.1TIMELESS, CRY2, NR1D1, NFIL3, BHLHE41, PER1

Molecular functions related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FAD bindingGO:07194910.5DAO, CRY2
2protein binding transcription factor activityGO:00098810.5PER1, CRY2
3RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00097810.4PER1, BHLHE41
4RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.4DBP, NFIL3
5E-box bindingGO:07088810.3BHLHE41, PER1
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negativeGO:00107810.1BHLHE41, NFIL3

Products for genes affiliated with Bipolar I Disorder

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Sources for Bipolar I Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet