MCID: BPL002
MIFTS: 41

Bipolar I Disorder malady

Summaries for Bipolar I Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Bipolar I disorder (BP-I; pronounced \"type one bipolar disorder\") is a bipolar spectrum disorder... more...

MalaCards: Bipolar I Disorder is related to bipolar disorder and schizophrenia. An important gene associated with Bipolar I Disorder is EGR3 (early growth response 3), and among its related pathways are Metabolic States and Circadian Oscillators and Circadian rhythm pathway. The compound riboflavin have been mentioned in the context of this disorder. Affiliated tissues include cortex, amygdala and prefrontal cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A bipolar disorder that is characterized by at least one manic or mixed episode.

Aliases & Classifications for Bipolar I Disorder

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

bipolar i disorder 8 10 60


External Ids:

Disease Ontology8 DOID:14042
SNOMED-CT56 49468007
ICD9CM27 296.50

Related Diseases for Bipolar I Disorder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bipolar I Disorder:



Diseases related to bipolar i disorder

Clinical Features for Bipolar I Disorder

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Drugs & Therapeutics for Bipolar I Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bipolar I Disorder

Drug clinical trials:

Search ClinicalTrials for Bipolar I Disorder

Search NIH Clinical Center for Bipolar I Disorder

Search CenterWatch for Bipolar I Disorder

Genetic Tests for Bipolar I Disorder

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Anatomical Context for Bipolar I Disorder

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32MalaCards
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MalaCards organs/tissues related to Bipolar I Disorder:

32
Cortex, Amygdala, Prefrontal cortex, B lymphoblasts, Testes, Brain, Cingulate cortex, Monocytes, Cerebellum, Pituitary, Bone marrow, Bone

Animal Models for Bipolar I Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bipolar I Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.2EGR3, CHRNA2, DBP, DAO, SLC18A1, PER1
2MP:00053869.8PER1, CSNK1E, CRY2, EGR3, NR1D1, BHLHE41

Publications for Bipolar I Disorder

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50PubMed
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Articles related to Bipolar I Disorder:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Asenapine treatment and health-related quality of life in patients experiencing bipolar I disorder with mixed episodes: post-hoc analyses of pivotal trials. (24329543)
2014
2
Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients. (23837831)
2013
3
Glycogen synthase kinase 3I^ gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium. (23021822)
2013
4
Cross-national prevalence and cultural correlates of bipolar I disorder. (24306039)
2013
5
Patterns of atypical antipsychotic therapy use in adults with bipolar I disorder in the USA. (23861367)
2013
6
Clinical significance of treatment effects with aripiprazole versus placebo in a study of manic or mixed episodes associated with pediatric bipolar I disorder. (23480324)
2013
7
Treatment adherence in bipolar I and schizoaffective disorder, bipolar type. (24099884)
2013
8
Overlapping and distinct gray and white matter abnormalities in schizophrenia and bipolar I disorder. (23796123)
2013
9
Limbic and callosal white matter changes in euthymic bipolar I disorder: an advanced diffusion magnetic resonance imaging tractography study. (23158457)
2013
10
Neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene associated with treatment response to mood stabilizers in patients with bipolar I disorder. (23315174)
2013
11
Factors affecting treatment compliance in patients with bipolar I disorder during prophylaxis: a study from Turkey. (24359677)
2013
12
Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients. (21943930)
2012
13
Predominant recurrence polarity among 928 adult international bipolar I disorder patients. (22188017)
2012
14
Age at onset versus family history and clinical outcomes in 1,665 international bipolar-I disorder patients. (22295008)
2012
15
The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder. (22514151)
2012
16
Voxel-based morphometric analysis on the volume of gray matter in bipolar I disorder. (21236649)
2011
17
Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. (20361907)
2010
18
Time to rehospitalization in patients with major depression vs. those with schizophrenia or bipolar I disorder in a public psychiatric hospital. (20494450)
2010
19
A new BALANCE in bipolar I disorder. (20092883)
2010
20
Descriptive epidemiology of bipolar I disorder among United States military personnel. (20446499)
2010
21
Polarity of the first episode and time to diagnosis of bipolar I disorder. (20046381)
2009
22
Executive functioning in twins with bipolar I disorder and healthy co-twins. (19661106)
2009
23
Correlates of metabolic abnormalities in bipolar I disorder at initiation of acute phase treatment. (20046379)
2009
24
Cost-effectiveness of quetiapine with lithium or divalproex for maintenance treatment of bipolar I disorder. (19769548)
2009
25
A non-randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady-state pharmacokinetics of lamotrigine in patients with bipolar I disorder. (19132712)
2009
26
The specific burden of comorbid anxiety disorders and of substance use disorders in bipolar I disorder. (18199243)
2008
27
Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population. (18797398)
2008
28
Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder. (17681086)
2008
29
The effect of bipolar I disorder and major depressive disorder on workforce function. (18341762)
2008
30
Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions. (17915973)
2007
31
Diagnostic characteristics of child bipolar I disorder: does the "Treatment of Early Age Mania (team)" sample generalize? (17335331)
2007
32
Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder. (17680916)
2007
33
Common variations in ALG9 are not associated with bipolar I disorder: a family-based study. (16859551)
2006
34
Reactivity to a laboratory stressor among individuals with bipolar I disorder in full or partial remission. (16866593)
2006
35
Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report. (16542735)
2006
36
Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial. (17196048)
2006
37
Maintenance treatment with olanzapine reduces relapse in people with bipolar I disorder who have responded to acute olanzapine treatment. (16868192)
2006
38
The cost-effectiveness of lamotrigine in the maintenance treatment of adults with bipolar I disorder. (16792438)
2006
39
Spotlight on olanzapine in bipolar I disorder. (15963003)
2005
40
Correlates of insight among patients with bipolar I disorder in remission. (14672797)
2004
41
Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder. (14706725)
2004
42
A comparison of the phenomenology and treatment of youths and adults with bipolar I disorder in a state mental health system. (15094255)
2004
43
Olanzapine: a review of its use in the management of bipolar I disorder. (15537371)
2004
44
Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone. (15056579)
2004
45
The Maudsley Bipolar Disorder Project: the effect of medication, family history, and duration of illness on IQ and memory in bipolar I disorder. (12590629)
2003
46
Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. (12815743)
2003
47
Can clinical features of bipolar-I disorder be assessed reliably on the telephone? (12167521)
2002
48
Health care utilization and costs among privately insured patients with bipolar I disorder. (12519100)
2002
49
Manic episode in epilepsy and bipolar I disorder: a comparative analysis of 13 patients. (11554891)
2001
50
Concomitant neuroleptic malignant syndrome and lithium intoxication in a patient with bipolar I disorder: case report. (11126155)
2000

Genetic Variations for Bipolar I Disorder

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Expression for genes affiliated with Bipolar I Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bipolar I Disorder

Search GEO for disease gene expression data for Bipolar I Disorder.

Pathways for genes affiliated with Bipolar I Disorder

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Bipolar I Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4PER1, CRY2
210.3TIMELESS, CSNK1E, NR1D1, PER1
3
Hide members
10.2PER1, DBP, BHLHE41, NR1D1, CRY2, CSNK1E

Compounds for genes affiliated with Bipolar I Disorder

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Bipolar I Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1riboflavin44 11 2412.4SLC22A6, DAO

GO Terms for genes affiliated with Bipolar I Disorder

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16Gene Ontology
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Biological processes related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:07132010.4AANAT, EGR3
2circadian rhythmGO:00762310.2PER1, TIMELESS, CRY2, EGR3, NR1D1, NFIL3
3circadian regulation of gene expressionGO:03292210.1PER1, BHLHE41
4negative regulation of transcription from RNA polymerase II promoterGO:00012210.1TIMELESS, CRY2, NR1D1, NFIL3, BHLHE41, PER1

Molecular functions related to Bipolar I Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FAD bindingGO:07194910.5DAO, CRY2
2protein binding transcription factor activityGO:00098810.5PER1, CRY2
3RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00097810.4PER1, BHLHE41
4RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.4DBP, NFIL3
5E-box bindingGO:07088810.3BHLHE41, PER1
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negativeGO:00107810.1BHLHE41, NFIL3

Products for genes affiliated with Bipolar I Disorder

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Sources for Bipolar I Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet