Bizarre Leiomyoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Bizarre Leiomyoma

Sources:
¹⁰Disease Ontology, ¹²DISEASES, ⁶⁵UMLS, ⁴²NCIt, ⁵⁹SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Bizarre Leiomyoma:

Name: Bizarre Leiomyoma ¹⁰ ¹² ⁶⁵

Pleomorphic Leiomyoma ¹⁰

Symplastic Leiomyoma ¹⁰

Atypical Leiomyoma ¹⁰

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹⁰ DOID:5127

SNOMED-CT⁵⁹ 48897006

NCIt⁴² C4257

UMLS⁶⁵ C0334478

Summaries for Bizarre Leiomyoma

Sources:
³³MalaCards
See all MalaCards sources

MalaCards based summary: Bizarre Leiomyoma, also known as pleomorphic leiomyoma, is related to uterine corpus bizarre leiomyoma and leiomyoma. An important gene associated with Bizarre Leiomyoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways are BARD1 signaling events and GADD45 Pathway. Affiliated tissues include breast, prostate and ovary, and related mouse phenotypes are muscle and no phenotypic analysis.

Related Diseases for Bizarre Leiomyoma

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases related to Bizarre Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)

id	Related Disease	Score	Top Affiliating Genes
1	uterine corpus bizarre leiomyoma	12.2
2	leiomyoma	10.6
3	benign multicystic peritoneal mesothelioma	10.4	ACTC1, PGR
4	adult mesoblastic nephroma	10.4	ACTC1, PGR
5	ovarian mucinous cystadenocarcinoma	10.4	ACTC1, PCNA
6	thymus lipoma	10.4	ACTC1, PGR
7	oral tuberculosis	10.3	ACTC1, PGR
8	pyridoxal 5'-phosphate-dependent epilepsy	10.3	ACTC1, TP53
9	secretory meningioma	10.3	PCNA, PGR
10	prostatic cyst	10.3	PCNA, PGR
11	pulmonary immaturity	10.3	ACTC1, TP53
12	syringocystadenoma papilliferum	10.3	ACTC1, TP53
13	cervical adenoid cystic carcinoma	10.3	PCNA, PGR
14	small intestine leiomyosarcoma	10.3	ACTC1, TP53
15	proliferative fasciitis	10.3	ACTC1, TP53
16	metachronous kidney wilms' tumor	10.2	PGR, TP53
17	ovary neuroendocrine neoplasm	10.2	PGR, TP53
18	hypothyroidism due to deficient transcription factors involved in pituitary development or function	10.2	ACTC1, TP53
19	ovarian mesodermal adenosarcoma	10.2	PGR, TP53
20	pituitary stalk meningioma	10.2	PGR, TP53
21	cystadenoma	10.2	PGR, TP53
22	uterine corpus adenosarcoma	10.2	PGR, TP53
23	corneal neovascularization	10.2	PGR, TP53
24	pyelonephritis	10.2	PGR, TP53
25	exposure keratitis	10.2	PGR, TP53
26	skull base meningioma	10.2	PGR, TP53
27	internal auditory canal lipoma	10.2	PGR, TP53
28	immune system cancer	10.2	PGR, TP53
29	osteoblastoma	10.2	PGR, TP53
30	head and neck carcinoma	10.2	PGR, TP53
31	peritoneal cystic mesothelioma	10.2	PGR, TP53
32	fallopian tube leiomyosarcoma	10.2	PGR, TP53
33	uterine carcinosarcoma	10.2	PGR, TP53
34	eye carcinoma in situ	10.2	PGR, TP53
35	vulvar sarcoma	10.2	PGR, TP53
36	3-methylglutaconic aciduria, type i	10.2	PCNA, TP53
37	dyskinetic cerebral palsy	10.1	PGR, TP53
38	male reproductive organ benign neoplasm	10.1	PGR, TP53
39	ovary epithelial cancer	10.1	PGR, TP53
40	ovarian wilms' cancer	10.1	PGR, TP53
41	embryonal carcinoma	10.1	ACTC1, TP53
42	cervical endometrial stromal sarcoma	10.1	ACTC1, TP53
43	bone ameloblastoma	10.1	PCNA, TP53
44	malignant epithelial mesothelioma	10.1	ACTC1, CDKN2A
45	estrogen-receptor negative breast cancer	10.1	PGR, TP53
46	benign mesothelioma	10.1	ACTC1, CDKN2A
47	larynx sarcoma	10.1	PGR, TP53
48	periocular meningioma	10.1	PGR, TP53
49	prostatitis	10.1
50	leiomyosarcoma	10.1

Graphical network of the top 20 diseases related to Bizarre Leiomyoma:

Symptoms for Bizarre Leiomyoma

Drugs & Therapeutics for Bizarre Leiomyoma

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials
See all MalaCards sources

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Bizarre Leiomyoma

Genetic Tests for Bizarre Leiomyoma

Anatomical Context for Bizarre Leiomyoma

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Bizarre Leiomyoma:

³³

Breast, Prostate, Ovary, Pituitary, Colon, Uterus, Monocytes

Animal Models for Bizarre Leiomyoma or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Bizarre Leiomyoma:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	8.1	ACTC1, CDKN2A, PGR, TP53
2	no phenotypic analysis	MP:0003012	7.7	CDKN2A, PCNA, PGR, TP53

Publications for Bizarre Leiomyoma

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Bizarre Leiomyoma:

(show all 22)

id	Title	Authors	Year
1	Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. (26960523)	Swami S.Y.... Girji D.D.	2015
2	Bizarre leiomyoma of the scrotum: A case report and review of the literature. (24765204)	Su Z.... Lai Y.	2014
3	Successful pregnancy outcome after laparoscopic-assisted excision of a bizarre leiomyoma: a case report. (21812974)	Takeda A.... Nakamura H.	2011
4	Bizarre leiomyoma of the posterior vaginal fornix. (18501906)	Vlahos N.... Moraitis D.	2008
5	A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature. (19068127)	Masood J.... Carr T.W.	2008
6	Bizarre leiomyoma of scrotum. (16146275)	Celia A.... Bianchi G.	2005
7	Bizarre leiomyoma of the soft tissue. (16194835)	Son H.J.... Moon W.S.	2005
8	Pathologic quiz case: a 69-year-old asymptomatic man with a scrotal mass. Atypical (symplastic or bizarre) leiomyoma of the scrotum. (14736263)	Fadare O.... Mariappan M.R.	2004
9	Bizarre leiomyoma of the scrotum. (12808340)	Kim N.R.... Han J.	2003
10	Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change. (12401830)	Vincenzi A.... Rivasi F.	2002
11	A clinicopathological study of bizarre leiomyoma]. (12485480)	Li B.... Wang D.	2002
12	Bizarre leiomyoma of the epididymis. A case report. (11517827)	Borri A.... Pernice L.M.	2000
13	Bizarre leiomyoma of the vagina: report of a case. (10782419)	Biankin S.A.... Russell P.	2000
14	Bizarre leiomyoma of the prostate. (9126110)	Khalil K.H.... al-Rufaie H.K.	1997
15	Neoplastic association of leiomyoma, bizarre leiomyoma and leiomyosarcoma uteri. Case report. (7828608)	Tartagni M.... Loizzi P.	1994
16	Bizarre leiomyoma of the renal pelvis with ultrastructural and immunohistochemical findings. (2926892)	Kho G.T.... Duggan M.A.	1989
17	Complex karyotypic anomalies in a bizarre leiomyoma of the uterus. (2487152)	Nilbert M.... Mitelman F.	1989
18	Bizarre leiomyoma of the prostate. (3125678)	KA!rolyi P.... TAPnkAPl I.	1988
19	Uterine bizarre leiomyoma. (7113686)	KlA1nder K.B.... ller P.C.	1982
20	Bizarre leiomyoma of the stomach: Case report. (5266968)	Xipell J.M.	1970
21	A comprative electron microscopic study of a leiomyosarcoma and bizarre leiomyoma (leiomyoblastoma) of the stomach. (5820970)	Kay S.... STILL W.J.	1969
22	Bizarre leiomyoma (leiomyoblastoma). Report of a case. (14009016)	Yarington C.T.... Cook M.D.	1962

Genes related to Bizarre Leiomyoma

Sources:
²⁰GeneCards, ⁷Cosmic, ¹²DISEASES
See all MalaCards sources

Genes related to Bizarre Leiomyoma:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	ACTC1	Actin, Alpha, Cardiac Muscle 1	17.93	GeneCards inferred via : Publications (show sections)
2	PCNA	Proliferating Cell Nuclear Antigen	17.93	GeneCards inferred via : Publications (show sections)
3	TP53	Tumor Protein P53	15.34	DISEASES inferred ¹²
4	CDKN2A	Cyclin-Dependent Kinase Inhibitor 2A	15.27	DISEASES inferred ¹²
5	PGR	Progesterone Receptor	15.17	DISEASES inferred ¹²

Variations for Bizarre Leiomyoma

Expression for genes affiliated with Bizarre Leiomyoma

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Bizarre Leiomyoma.

Pathways for genes affiliated with Bizarre Leiomyoma

Sources:
⁵²PathCards, ³⁹NCBI BioSystems Database, ⁵⁵QIAGEN, ⁶²Thomson Reuters, ⁵⁷Reactome, ³¹KEGG, ⁵⁶R&D Systems
See all MalaCards sources

Pathways related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

(show all 18)

id	Super pathways	Score	Top Affiliating Genes
1	BARD1 signaling events³⁹	9.3	PCNA, TP53
2	GADD45 Pathway⁵⁵	9.3	PCNA, TP53
3	DNA damage_Role of Brca1 and Brca2 in DNA repair⁶²	9.3	PCNA, TP53
4	RB in Cancer³⁹	9.3	PCNA, TP53
5	DNA damage_ATM/ATR regulation of G1/S checkpoint⁶²	9.3	PCNA, TP53
6	Transcription_P53 signaling pathway⁶²	9.0	CDKN2A, TP53
7	Regulation of TP53 Expression and Degradation⁵⁷ Show member pathways Regulation of TP53 Degradation⁵⁷ Regulation of TP53 Expression⁵⁷	9.0	CDKN2A, TP53
8	HIF1Alpha Pathway⁵⁵	9.0	CDKN2A, TP53
9	Bladder cancer³¹	9.0	CDKN2A, TP53
10	Oncogene Induced Senescence⁵⁷	9.0	CDKN2A, TP53
11	TP53 network³⁹ Show member pathways Activation, translocation and oligomerization of BAX⁵⁷	9.0	CDKN2A, TP53
12	Inhibition of Ribosome Biogenesis by p14(ARF)⁵⁵	9.0	CDKN2A, TP53
13	Cell cycle³¹ ³⁹	8.5	CDKN2A, PCNA, TP53
14	p53 Pathway (RnD)⁵⁶ Show member pathways p53 Pathway⁵⁶	8.5	CDKN2A, PCNA, TP53
15	HTLV-I infection³¹	8.5	CDKN2A, PCNA, TP53
16	Mitotic G1-G1/S phases⁵⁷ Show member pathways G1 to S cell cycle control³⁹ G1/S Transition⁵⁷	8.5	CDKN2A, PCNA, TP53
17	Senescence and Autophagy³⁹	8.5	CDKN2A, PCNA, TP53
18	SUMOylation⁵⁷ Show member pathways SUMO E3 ligases SUMOylate target proteins⁵⁷ SUMOylation of DNA damage response and repair proteins⁵⁷ SUMOylation of transcription factors⁵⁷ SUMOylation of chromatin organization proteins⁵⁷ SUMO is transferred from E1 to E2 (UBE2I, UBC9)⁵⁷ Processing and activation of SUMO⁵⁷ SUMO is conjugated to E1 (UBA2-SAE1)⁵⁷ SUMO is proteolytically processed⁵⁷	8.5	CDKN2A, PCNA, TP53

GO Terms for genes affiliated with Bizarre Leiomyoma

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Biological processes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle arrest	GO:0007050	9.5	CDKN2A, TP53
2	nucleotide-excision repair	GO:0006289	9.2	PCNA, TP53
3	negative regulation of cell growth	GO:0030308	9.1	CDKN2A, TP53
4	replicative senescence	GO:0090399	9.0	CDKN2A, TP53
5	protein sumoylation	GO:0016925	8.8	CDKN2A, PCNA, TP53
6	apoptotic process	GO:0006915	8.3	ACTC1, CDKN2A, TP53

Sources for Bizarre Leiomyoma

¹BitterDB

²CDC

³Cell Signaling Technology

⁴ClinicalTrials

⁵Clinvar

⁶Cochrane Library

⁷Cosmic

⁸dbSNP

⁹DGIdb

¹⁰Disease Ontology

¹¹diseasecard

¹²DISEASES

¹³DrugBank

¹⁴ExPASy

¹⁵FDA

¹⁶FMA

¹⁷Gene Expression Omnibus DataSets

¹⁸Gene Ontology

¹⁹GeneAnalytics

²⁰GeneCards

²¹GeneReviews

²²GeneTests

²³Genetics Home Reference

²⁴GTR

²⁵HGMD

²⁶HMDB

²⁷ICD10

²⁸ICD10 via Orphanet

²⁹ICD9CM

³⁰IUPHAR

³¹KEGG

³²LifeMap Discovery®

³³MalaCards

³⁴MedGen

³⁵MedlinePlus

³⁶MeSH

³⁷MESH via Orphanet

³⁸MGI

³⁹NCBI BioSystems Database

⁴⁰NCBI Bookshelf

⁴¹NCI

⁴²NCIt

⁴³NDF-RT

⁴⁴NIH Clinical Center

⁴⁵NIH Rare Diseases

⁴⁶NINDS

⁴⁷Novoseek

⁴⁸Novus Biologicals

⁴⁹OMIM

⁵⁰OMIM via Orphanet

⁵¹Orphanet

⁵²PathCards

⁵³PharmGKB

⁵⁴PubMed

⁵⁵QIAGEN

⁵⁶R&D Systems

⁵⁷Reactome

⁵⁸SinoBiological

⁵⁹SNOMED-CT

⁶⁰SNOMED-CT via Orphanet

⁶¹The Human Phenotype Ontology

⁶²Thomson Reuters

⁶³Tocris Bioscience

⁶⁴Tumor Gene Family of Databases

⁶⁵UMLS

⁶⁶UMLS via Orphanet

⁶⁷UniProtKB/Swiss-Prot

⁶⁸Wikipedia

MCID: BZR001 MIFTS: 34	Bizarre Leiomyoma malady Category: Cancer diseases
Genes Tissues Related diseases Publications Pathways Download this MalaCard Expand all tables

Bizarre Leiomyoma malady