MCID: BZR001
MIFTS: 31

Bizarre Leiomyoma

Categories: Cancer diseases

Aliases & Classifications for Bizarre Leiomyoma

MalaCards integrated aliases for Bizarre Leiomyoma:

Name: Bizarre Leiomyoma 12 14 69
Pleomorphic Leiomyoma 12
Symplastic Leiomyoma 12
Atypical Leiomyoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5127
NCIt 47 C4257
SNOMED-CT 64 48897006
UMLS 69 C0334478

Summaries for Bizarre Leiomyoma

MalaCards based summary : Bizarre Leiomyoma, also known as pleomorphic leiomyoma, is related to uterine corpus bizarre leiomyoma and cutaneous leiomyosarcoma. An important gene associated with Bizarre Leiomyoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gene Expression and SUMOylation. Affiliated tissues include prostate, uterus and smooth muscle, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Bizarre Leiomyoma

Diseases related to Bizarre Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
id Related Disease Score Top Affiliating Genes
1 uterine corpus bizarre leiomyoma 12.0
2 cutaneous leiomyosarcoma 10.5 ACTC1 PGR
3 berk-tabatznik syndrome 10.5 ACTC1 PGR
4 liver angiosarcoma 10.5 ACTC1 PGR
5 sebaceous adenoma 10.5 ACTC1 PGR
6 blastema predominant kidney wilms' tumor 10.5 PGR TP53
7 central nervous system organ benign neoplasm 10.5 PGR TP53
8 lip carcinoma in situ 10.5 ACTC1 PGR
9 lung adenoma 10.5 PGR TP53
10 large cell acanthoma 10.5 ACTC1 PGR
11 lymphocytic infiltrate of jessner 10.5 PCNA PGR
12 breast myoepithelial neoplasm 10.5 PGR TP53
13 intestinal perforation 10.5 PGR TP53
14 prostatic acinar adenocarcinoma 10.5 PGR TP53
15 intraductal breast myoepitheliosis 10.5 PGR TP53
16 leiomyoma 10.5
17 ovarian mesodermal adenosarcoma 10.5 PGR TP53
18 breast pericanalicular fibroadenoma 10.5 PGR TP53
19 chest wall lymphoma 10.5 PGR TP53
20 colon neuroendocrine neoplasm 10.5 PGR TP53
21 central nervous system germ cell tumor 10.4 PGR TP53
22 breast fibrosarcoma 10.4 PGR TP53
23 otitis externa 10.4 PGR TP53
24 extragonadal nonseminomatous germ cell tumor 10.4 PGR TP53
25 fibula aplasia complex brachydactyly 10.4 ACTC1 PGR
26 pediatric meningioma 10.4 PCNA PGR
27 hemangioma of liver 10.4 ACTC1 TP53
28 hypersensitivity reaction type iii disease 10.4 PGR TP53
29 gangliosidosis gm2 10.4 ACTC1 PGR
30 linitis plastica 10.4 ACTC1 PGR
31 distal monosomy 7q36 10.4 PGR TP53
32 esophagus sarcoma 10.4 PCNA PGR
33 rectum kaposi's sarcoma 10.4 PGR TP53
34 lacrimal gland mucoepidermoid carcinoma 10.4 PGR TP53
35 fallopian tube carcinosarcoma 10.4 PGR TP53
36 pulmonary venoocclusive disease 10.4 ACTC1 TP53
37 group b strep disease in newborns 10.4 ACTC1 TP53
38 tenosynovitis of foot and ankle 10.4 PGR TP53
39 glomangioma 10.4 ACTC1 TP53
40 central nervous system tuberculosis 10.4 MED12 PGR
41 vulva adenocarcinoma 10.4 PGR TP53
42 retinal disease 10.4 PGR TP53
43 mediastinum rhabdomyosarcoma 10.4 PGR TP53
44 dental caries 10.4 PGR TP53
45 nasal cavity disease 10.3 PGR TP53
46 malignant syringoma 10.3 PCNA TP53
47 schwannoma of jugular foramen 10.3 PCNA TP53
48 pylorus cancer 10.3 PCNA TP53
49 mixed cerebral palsy 10.3 PGR TP53
50 vestibular gland benign neoplasm 10.3 PGR TP53

Graphical network of the top 20 diseases related to Bizarre Leiomyoma:



Diseases related to Bizarre Leiomyoma

Symptoms & Phenotypes for Bizarre Leiomyoma

MGI Mouse Phenotypes related to Bizarre Leiomyoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 MED12 PGR TP53 ACTC1 CDKN2A
2 mortality/aging MP:0010768 9.43 PCNA PGR TP53 ACTC1 CDKN2A MED12
3 no phenotypic analysis MP:0003012 8.92 PCNA PGR TP53 CDKN2A

Drugs & Therapeutics for Bizarre Leiomyoma

Search Clinical Trials , NIH Clinical Center for Bizarre Leiomyoma

Genetic Tests for Bizarre Leiomyoma

Anatomical Context for Bizarre Leiomyoma

MalaCards organs/tissues related to Bizarre Leiomyoma:

39
Prostate, Uterus, Smooth Muscle

Publications for Bizarre Leiomyoma

Articles related to Bizarre Leiomyoma:

(show all 22)
id Title Authors Year
1
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
2
Bizarre leiomyoma of the scrotum: A case report and review of the literature. ( 24765204 )
2014
3
Successful pregnancy outcome after laparoscopic-assisted excision of a bizarre leiomyoma: a case report. ( 21812974 )
2011
4
Bizarre leiomyoma of the posterior vaginal fornix. ( 18501906 )
2008
5
A rare symplastic or bizarre leiomyoma of the scrotum: a case report and review of the literature. ( 19068127 )
2008
6
Bizarre leiomyoma of the soft tissue. ( 16194835 )
2005
7
Bizarre leiomyoma of scrotum. ( 16146275 )
2005
8
Pathologic quiz case: a 69-year-old asymptomatic man with a scrotal mass. Atypical (symplastic or bizarre) leiomyoma of the scrotum. ( 14736263 )
2004
9
Bizarre leiomyoma of the scrotum. ( 12808340 )
2003
10
Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change. ( 12401830 )
2002
11
[A clinicopathological study of bizarre leiomyoma]. ( 12485480 )
2002
12
Bizarre leiomyoma of the vagina: report of a case. ( 10782419 )
2000
13
Bizarre leiomyoma of the epididymis. A case report. ( 11517827 )
2000
14
Bizarre leiomyoma of the prostate. ( 9126110 )
1997
15
Neoplastic association of leiomyoma, bizarre leiomyoma and leiomyosarcoma uteri. Case report. ( 7828608 )
1994
16
Bizarre leiomyoma of the renal pelvis with ultrastructural and immunohistochemical findings. ( 2926892 )
1989
17
Complex karyotypic anomalies in a bizarre leiomyoma of the uterus. ( 2487152 )
1989
18
Bizarre leiomyoma of the prostate. ( 3125678 )
1988
19
Uterine bizarre leiomyoma. ( 7113686 )
1982
20
Bizarre leiomyoma of the stomach: Case report. ( 5266968 )
1970
21
A comprative electron microscopic study of a leiomyosarcoma and bizarre leiomyoma (leiomyoblastoma) of the stomach. ( 5820970 )
1969
22
Bizarre leiomyoma (leiomyoblastoma). Report of a case. ( 14009016 )
1962

Variations for Bizarre Leiomyoma

Expression for Bizarre Leiomyoma

Search GEO for disease gene expression data for Bizarre Leiomyoma.

Pathways for Bizarre Leiomyoma

Pathways related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 CDKN2A MED12 PCNA PGR TP53
2
Show member pathways
12.25 CDKN2A PCNA TP53
3
Show member pathways
12.22 CDKN2A PCNA TP53
4 12.14 CDKN2A PCNA TP53
5
Show member pathways
12.13 CDKN2A PCNA PGR TP53
6 11.99 CDKN2A PCNA TP53
7 11.86 CDKN2A PCNA TP53
8 11.45 CDKN2A TP53
9 11.45 CDKN2A TP53
10
Show member pathways
11.44 CDKN2A TP53
11 11.29 CDKN2A TP53
12 11.26 CDKN2A TP53
13 11.26 CDKN2A PCNA TP53
14 11.15 PCNA TP53
15 10.96 PCNA TP53
16 10.94 CDKN2A TP53
17 10.83 PCNA TP53
18 10.82 CDKN2A PCNA TP53
19 10.6 CDKN2A TP53
20
Show member pathways
10.5 CDKN2A TP53

GO Terms for Bizarre Leiomyoma

Cellular components related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 PCNA TP53

Biological processes related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.46 CDKN2A MED12 PGR TP53
2 Ras protein signal transduction GO:0007265 9.37 CDKN2A TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.32 PCNA TP53
4 positive regulation of gene expression GO:0010628 9.26 ACTC1 TP53
5 cellular response to UV GO:0034644 8.96 PCNA TP53
6 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Bizarre Leiomyoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.54 MED12 PCNA TP53
2 enzyme binding GO:0019899 9.5 PCNA PGR TP53
3 damaged DNA binding GO:0003684 9.4 PCNA TP53
4 transcription factor binding GO:0008134 9.33 CDKN2A MED12 TP53
5 receptor tyrosine kinase binding GO:0030971 9.26 PCNA TP53
6 disordered domain specific binding GO:0097718 8.65 TP53
7 histone acetyltransferase binding GO:0035035 8.62 PCNA TP53

Sources for Bizarre Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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