MCID: BLC004
MIFTS: 33

Blackwater Fever malady

Blood category

Summaries for Blackwater Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with plasmodium falciparum or plasmodium vivax.

MalaCards: Blackwater Fever, also known as malarial hemoglobinuria, is related to hemoglobinuria and q fever. An important gene associated with Blackwater Fever is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways is Binding and Uptake of Ligands by Scavenger Receptors. The compounds 23-diphosphoglycerate and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotype homeostasis/metabolism.

Wikipedia:64 (see PMID 23402997 and PMID 22931368) more...

Aliases & Classifications for Blackwater Fever

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 27ICD9CM, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

blackwater fever 8 10 45 61
malarial hemoglobinuria 8
hemoglobinuric, malaria 8
black water fever 8


External Ids:

Disease Ontology8 DOID:14068
MeSH35 D001742
SNOMED-CT57 56625005
NCIt40 C34426
ICD9CM27 084.8

Related Diseases for Blackwater Fever

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to blackwater fever

Clinical Features for Blackwater Fever

Drugs & Therapeutics for Blackwater Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

Sources:
33MalaCards
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MalaCards organs/tissues related to Blackwater Fever:

33
Kidney

Animal Models for Blackwater Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Blackwater Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0KIF5B, HPX, HP, G6PD

Publications for Blackwater Fever

Sources:
51PubMed
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Articles related to Blackwater Fever:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. (23767699)
2013
2
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. (23800033)
2013
3
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. (14584376)
2003
4
Methemalbuminnemia after massive hemolysis during blackwater fever]. (12805012)
2003
5
Blackwater fever treated with artemether. (11996443)
2001
6
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. (11283802)
2001
7
Blackwater fever: a fatal case. (9434932)
1997
8
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. (9402415)
1997
9
Blackwater fever and acute renal failure in expatriates in Africa. (8827999)
1996
10
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. (7859663)
1994
11
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. (3130932)
1988
12
Quinine and the mystery of blackwater fever. (3321835)
1987
13
Splenectomy and blackwater fever. (7104241)
1982
14
Blackwater fever in Kenya: problems of etiology. (4578485)
1973
15
Erythrocyte morphology in blackwater fever. (5485713)
1970
16
The kidney in blackwater fever: light and electron microscopic observations. (4171380)
1968
17
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. (14055154)
1963
18
Treatment of blackwater fever with prednisone. (13386233)
1956
19
Blackwater fever; its etiology and treatment. (13246757)
1955
20
A fatal case of blackwater fever associated with ingestion of nivaquine. (13169242)
1954
21
Proguanil and blackwater fever. (13019138)
1953
22
Blackwater fever and the intravascular haemolyses. (13058138)
1952
23
BLACKWATER fever. (14848575)
1951
24
Observations on the mechanism of haemolysis in blackwater fever. (14908092)
1951
25
Observations on the mechanism of blackwater fever; an experimental study in the monkey. (14804092)
1950
26
Blackwater fever in West Africa, 1941-45; blackwater fever in European military personnel. (15393586)
1949
27
Proguanil and blackwater fever. (18224799)
1949
28
Blackwater fever in West Africa; 1941-45; blackwater fever in African military personnel. (15393593)
1949
29
A case of blackwater fever. (18117888)
1949
30
Hemoglobinuria, blackwater fever, in monkeys; a consideration of the disease in man. (18113078)
1949
31
Malaria and blackwater fever in Macedonia and Thrace in relation to DDT. (18891441)
1948
32
Attempts to induce blackwater fever experimentally. (20249286)
1947
33
A hepatic syndrome of wide distribution illustrated by lesions in malaria and blackwater fever. (20272628)
1947
34
Experiments on the relation of haemoglobinuria and anuria with reference to blackwater fever. (18902131)
1947
35
Blackwater fever. (20994534)
1946
36
Blackwater fever after delivery]. (20985982)
1946
37
Autoantigens and autoantibodies in the pathogenesis of disease with special refenence to blackwater fever. (21020353)
1945-1946
38
On a fatal case of blackwater fever with pseudo-methaemoglobinemia. (21028572)
1945
39
Blackwater Fever in West Africa. (20785946)
1945
40
BLACKWATER FEVER. (20780859)
1937
41
SOME OBSERVATIONS ON BLACKWATER FEVER. (20771869)
1925
42
BLACKWATER FEVER: ITS ETIOLOGY AND PARASITOLOGY. (20771378)
1923
43
A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER. (20770160)
1921
44
NOTES ON BLACKWATER FEVER. (20770054)
1920
45
A REPUTED SPECIFIC FOR BLACKWATER FEVER. (17817189)
1916
46
Observations on the Inhibitory Influence exerted by Hypertonic Saline Solutions and Calcium Chloride Solutions on the Action of Specific Haemolysins, with Suggestions as to the Therapy of Blackwater Fever. (16742160)
1911
47
NOTES ON A CASE OF QUININE HAEMOGLOBINURIA OR BLACKWATER FEVER. (20762926)
1906
48
EXPERIMENTAL HAEMOGLOBINURIA IN A CASE OF BLACKWATER FEVER. (20760898)
1903
49
BLACKWATER FEVER. (20760014)
1902
50
Observations on Blackwater Fever. (20759804)
1901

Genetic Variations for Blackwater Fever

Expression for genes affiliated with Blackwater Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for genes affiliated with Blackwater Fever

Sources:
54Reactome
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Pathways related to Blackwater Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3HPX, HP

Compounds for genes affiliated with Blackwater Fever

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Blackwater Fever according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate459.7HP, G6PD
2thiobarbituric acid459.7G6PD, HP
3zinc protoporphyrin459.7G6PD, HP
4cyanide45 2410.7HP, HPX
5protoporphyrin ix45 11 2411.7HPX, HP
6tocopherol459.7HP, G6PD
7starch459.7G6PD, HP
8cellulose acetate459.7G6PD, HP
9sulfasalazine45 29 50 1112.7HP, G6PD
10ribavirin45 50 1111.7HP, G6PD
11lactose45 1110.7HP, G6PD
12vitamin b12459.6HP, G6PD
13malondialdehyde459.6G6PD, HP
14uric acid45 2410.6HP, G6PD
15chloroquine45 2 50 29 1113.6G6PD, HP
16polyethylene glycol459.6HP, G6PD
17glucose 6-phosphate45 2410.6HP, G6PD
18vitamin-e459.6G6PD, HP
19citrate459.5HP, G6PD
20agarose459.5HP, HPX
21thyroxine45 2410.5G6PD, HP
22hyaluronic acid45 2410.4HPX, HP
23folate459.4HP, G6PD
24aspirin45 50 29 2412.3G6PD, HP
25nacl459.3HPX, HP
26vitamin a45 11 2411.2HPX, HP
27ascorbic acid45 2410.2HP, G6PD, HPX
28h2o2459.1HPX, G6PD, HP
29atp45 299.4KIF5B, G6PD, HP, HPX
30lipid458.2HP, KIF5B, G6PD

GO Terms for genes affiliated with Blackwater Fever

Sources:
16Gene Ontology
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Cellular components related to Blackwater Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.3HPX, HP

Biological processes related to Blackwater Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:0068799.3HPX, HP

Products for genes affiliated with Blackwater Fever

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  • Proteins
  • Lysates
  • Antibodies

Sources for Blackwater Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet