Blackwater Fever malady

Disease Ontology: A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with plasmodium falciparum or plasmodium vivax.⁶

MalaCards: Blackwater Fever, also known as black water fever (disorder), is related to paroxysmal nocturnal hemoglobinuria and anemia. An important gene associated with Blackwater Fever is G6PD (glucose-6-phosphate dehydrogenase). The compounds 23-diphosphoglycerate and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotype homeostasis/metabolism.

Wikipedia: Blackwater fever is a complication of malaria in which red blood cells burst in the bloodstream...⁴⁴ more...

Aliases & Descriptions:

blackwater fever 6 8 32 43 black water fever (disorder) 6 malarial hemoglobinuria 6

hemoglobinuric, malaria 6 hemoglobinuria 43

Diseases related to blackwater fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 63)

id	Related Disease	Score	Top Affiliating Genes
1	paroxysmal nocturnal hemoglobinuria	37.4	G6PD, HP
2	anemia	31.0	HP, HPX, G6PD
3	hemoglobinuria	29.5	G6PD, HP
4	favism	12.9	G6PD, HP
5	congenital hemolytic anemia	12.9	HP, G6PD
6	glucosephosphate dehydrogenase deficiency	12.9	G6PD, HP
7	hereditary elliptocytosis	12.8	HP, G6PD
8	methemoglobinemia	12.8	HP, G6PD
9	bilirubin metabolic disorder	12.8	HP, G6PD
10	priapism	12.8	G6PD, HP
11	elliptocytosis	12.8	HP, G6PD
12	cerebral malaria	12.8	HP, G6PD
13	hereditary spherocytosis	12.8	HP, G6PD
14	spherocytosis	12.8	HP, G6PD
15	neonatal jaundice	12.8	G6PD, HP
16	alpha thalassemia	12.8	HP, G6PD
17	hemoglobinopathy	12.8	HP, G6PD
18	congenital hypothyroidism	12.8	HP, G6PD
19	rheumatic fever	12.8	HP, G6PD
20	autoimmune hemolytic anemia	12.8	G6PD, HP
21	cholelithiasis	12.8	G6PD, HP
22	plasmodium falciparum malaria	12.7	HP, G6PD
23	beta thalassemia	12.7	HP, G6PD
24	hepatitis e	12.7	HPX, G6PD
25	jaundice	12.7	HP, G6PD
26	acne	12.6	G6PD, HP
27	retinol binding protein	12.6	HP, HPX
28	viral hepatitis	12.5	HP, G6PD
29	laryngeal cancer	12.5	HP, HPX
30	pulmonary tuberculosis	12.4	HP, G6PD
31	sickle cell disease	12.3	G6PD, HP
32	hemolytic anemia	12.2	HP, HPX, G6PD
33	vascular disease	12.1	HP, G6PD
34	blindness	12.1	G6PD, HPX, HP
35	galactosemia	12.0	G6PD, HPX, HP
36	atherosclerosis	11.9	HP, HPX, G6PD
37	glioblastoma	11.8	HP, HPX, G6PD
38	alzheimer's disease	11.3	KIF5B, HP, HPX, G6PD
39	aplastic anemia	8.3
40	paroxysmal cold hemoglobinuria	7.7
41	leukemia	7.0
42	hematopoiesis	7.0
43	myelodysplastic syndrome	6.6
44	paroxysmal nocturnal hemoglobinuria, somatic	6.6
45	thrombosis	6.6
46	pancytopenia	6.1
47	vesiculitis	6.1
48	periventricular nodular heterotopia	5.2
49	retinal vascular occlusion	5.2
50	retinitis	5.2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to blackwater fever:

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MGI Mouse Phenotypes related to blackwater fever:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.0	KIF5B, HP, HPX, G6PD

Articles related to blackwater fever:

id	Title	Authors	Year	Affiliating Genes
1	Methemalbuminnemia after massive hemolysis during blackwater fever (12805012)	Gidenne S.... Burnat P.	2003	HP, HPX
2	The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. (9402415)	Houston S.	1997	G6PD
3	Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. (8953071)	Tran T.H.... White N.J.	1996	G6PD
4	An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. (7794063)	Delacollette C.... Wery M.	1995	G6PD, HP
5	Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. (7859663)	Bhatt K.M.... Okelo G.B.	1994	G6PD

Genes related to blackwater fever according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
2	HPX	hemopexin	11.0	Publications
3	KIF5B	kinesin family member 5B	11.0
4	HP	haptoglobin	11.0	Publications

Compounds related to blackwater fever according to GeneDecks:

(show all 25)

id	Compound	Score	Top Affiliating Genes
1	23-diphosphoglycerate32	9.8	HP, G6PD
2	thiobarbituric acid32	9.8	HP, G6PD
3	zinc protoporphyrin32	9.8	HP, G6PD
4	tocopherol32	9.8	HP, G6PD
5	starch32	9.7	HP, G6PD
6	cellulose acetate32	9.7	G6PD, HP
7	ribavirin32 34 9 9	12.7	HP, G6PD
8	lactose32 9 9	11.7	HP, G6PD
9	vitamin b1232	9.7	G6PD, HP
10	malondialdehyde32	9.7	HP, G6PD
11	cyanide32 18	10.7	HP, HPX
12	protoporphyrin ix32 9 18 9	12.7	HP, HPX
13	chloroquine32 34 9 9	12.7	G6PD, HP
14	uric acid32 18	10.6	HP, G6PD
15	polyethylene glycol32	9.6	HP, G6PD
16	glucose 6-phosphate32 18	10.6	G6PD, HP
17	vitamin-e32	9.5	G6PD, HP
18	citrate32	9.5	HP, G6PD
19	folate32	9.4	HP, G6PD
20	thyroxine32 18	10.3	G6PD, HP
21	agarose32	9.3	HP, HPX
22	ascorbic acid32 18	10.1	G6PD, HPX, HP
23	h2o232	9.0	HP, HPX, G6PD
24	hyaluronic acid32 18	10.0	HP, HPX
25	atp32	8.3	G6PD, HPX, HP, KIF5B

Biological processes related to blackwater fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular iron ion homeostasis	GO:006879	9.3	HP, HPX