MCID: BLC004
MIFTS: 37

Blackwater Fever malady

Blood diseases category

Summaries for Blackwater Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with plasmodium falciparum or plasmodium vivax.

MalaCards: Blackwater Fever, also known as malarial hemoglobinuria, is related to hemoglobinuria and malaria. An important gene associated with Blackwater Fever is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways is Binding and Uptake of Ligands by Scavenger Receptors. The compounds thiobarbituric acid and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 (see PMID 23402997 and PMID 22931368) more...

Aliases & Classifications for Blackwater Fever

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 27ICD9CM, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

blackwater fever 8 10 44 60
malarial hemoglobinuria 8
hemoglobinuric, malaria 8
black water fever 8


External Ids:

Disease Ontology8 DOID:14068
MeSH34 D001742
SNOMED-CT56 56625005
NCIt39 C34426
ICD9CM27 084.8

Related Diseases for Blackwater Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to blackwater fever

Clinical Features for Blackwater Fever

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Drugs & Therapeutics for Blackwater Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Blackwater Fever

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Anatomical Context for Blackwater Fever

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32MalaCards
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MalaCards organs/tissues related to Blackwater Fever:

32
Kidney

Animal Models for Blackwater Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Blackwater Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0KIF5B, HPX, HP, G6PD

Publications for Blackwater Fever

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50PubMed
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Articles related to Blackwater Fever:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. (23767699)
2013
2
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. (23800033)
2013
3
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. (14584376)
2003
4
Methemalbuminnemia after massive hemolysis during blackwater fever]. (12805012)
2003
5
Blackwater fever treated with artemether. (11996443)
2001
6
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. (9402415)
1997
7
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. (8953071)
1996
8
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. (7794063)
1995
9
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. (7859663)
1994
10
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. (3130932)
1988
11
Splenectomy and blackwater fever. (7104241)
1982
12
Blackwater fever in Kenya: problems of etiology. (4578485)
1973
13
Erythrocyte morphology in blackwater fever. (5485713)
1970
14
Autoimmune disease and blackwater fever. (4179535)
1969
15
A case of blackwater fever. (5661211)
1968
16
Oliguric renal failure in blackwater fever. (4881129)
1968
17
The kidney in blackwater fever: light and electron microscopic observations. (4171380)
1968
18
Blackwater fever in Southern Rhodesia in retrospect. (13975090)
1962
19
The artificial kidney in malaria and blackwater fever. (14450615)
1962
20
Treatment of blackwater fever with prednisone. (13386233)
1956
21
Proguanil and blackwater fever. (13019138)
1953
22
Blackwater fever in African children. (14830853)
1951
23
Observations on the mechanism of haemolysis in blackwater fever. (14908092)
1951
24
A heretofore unreported agglutinable human blood factor and its possible relationship to blackwater fever. (14771390)
1950
25
Blackwater fever in West Africa, 1941-45; blackwater fever in European military personnel. (15393586)
1949
26
Proguanil and blackwater fever. (18224799)
1949
27
Blackwater fever in West Africa; 1941-45; blackwater fever in African military personnel. (15393593)
1949
28
Malaria and blackwater fever in Macedonia and Thrace in relation to DDT. (18891441)
1948
29
Blackwater fever; modern theories; a critical review. (21003289)
1946
30
Blackwater fever. (20994534)
1946
31
Blackwater fever in Rhodes. (20988795)
1946
32
Blackwater fever after delivery]. (20985982)
1946
33
A case of blackwater fever during mepacrine therapy. (20286135)
1946
34
On a fatal case of blackwater fever with pseudo-methaemoglobinemia. (21028572)
1945
35
Blackwater Fever in West Africa. (20785946)
1945
36
Report of an attack of blackwater fever subsequent to induced malaria. (21005332)
1945
37
A case of blackwater fever in an African girl. (20293964)
1945
38
The Rh factor in blackwater fever; a preliminary note. (21005339)
1945
39
BLACKWATER FEVER. (20780859)
1937
40
SOME OBSERVATIONS ON BLACKWATER FEVER. (20771869)
1925
41
A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER. (20770160)
1921
42
NOTES ON BLACKWATER FEVER. (20770054)
1920
43
BLACKWATER FEVER IN MACEDONIA. (20769948)
1920
44
A REPUTED SPECIFIC FOR BLACKWATER FEVER. (17817189)
1916
45
A Case of Blackwater Fever in England. (20765693)
1911
46
NOTES ON A CASE OF QUININE HAEMOGLOBINURIA OR BLACKWATER FEVER. (20762926)
1906
47
EXPERIMENTAL HAEMOGLOBINURIA IN A CASE OF BLACKWATER FEVER. (20760898)
1903
48
BLACKWATER FEVER. (20760014)
1902
49
Observations on Blackwater Fever. (20759804)
1901
50
The Parasite of Malaria in the Tissues in a Fatal Case of Blackwater Fever. (20758514)
1899

Genetic Variations for Blackwater Fever

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Expression for genes affiliated with Blackwater Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for genes affiliated with Blackwater Fever

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53Reactome
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Pathways related to Blackwater Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3HPX, HP

Compounds for genes affiliated with Blackwater Fever

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Blackwater Fever according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid449.7HP, G6PD
223-diphosphoglycerate449.7HP, G6PD
3zinc protoporphyrin449.7G6PD, HP
4cyanide44 2410.7HPX, HP
5protoporphyrin ix44 11 2411.7HP, HPX
6tocopherol449.7HP, G6PD
7starch449.7HP, G6PD
8cellulose acetate449.7HP, G6PD
9sulfasalazine44 28 49 1112.7G6PD, HP
10ribavirin44 49 1111.7HP, G6PD
11lactose44 1110.7HP, G6PD
12vitamin b12449.6G6PD, HP
13malondialdehyde449.6HP, G6PD
14uric acid44 2410.6HP, G6PD
15chloroquine44 2 49 28 1113.6HP, G6PD
16polyethylene glycol449.6G6PD, HP
17glucose 6-phosphate44 2410.6HP, G6PD
18vitamin-e449.6HP, G6PD
19citrate449.5HP, G6PD
20agarose449.5HP, HPX
21thyroxine44 2410.5HP, G6PD
22hyaluronic acid44 2410.4HPX, HP
23folate449.4HP, G6PD
24aspirin44 49 28 2412.3HP, G6PD
25nacl449.3HP, HPX
26vitamin a44 11 2411.2HPX, HP
27ascorbic acid44 2410.2HPX, HP, G6PD
28h2o2449.1HPX, HP, G6PD
29atp44 289.4KIF5B, HPX, HP, G6PD
30lipid448.2KIF5B, HP, G6PD

GO Terms for genes affiliated with Blackwater Fever

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16Gene Ontology
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Cellular components related to Blackwater Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.3HPX, HP

Biological processes related to Blackwater Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:0068799.3HPX, HP

Products for genes affiliated with Blackwater Fever

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Blackwater Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet