MCID: BLC004
MIFTS: 34

Blackwater Fever

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Blackwater Fever

MalaCards integrated aliases for Blackwater Fever:

Name: Blackwater Fever 12 51 41 14 69
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 34 084.8
MeSH 41 D001742
NCIt 46 C34426
SNOMED-CT 64 56625005
UMLS 69 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to plasmodium falciparum malaria and malaria. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. The drugs Acetaminophen and Artesunate have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance and hematopoietic system

Wikipedia : 72 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CLIC1 G6PD HP HPX RPTOR CDKN2A
2 homeostasis/metabolism MP:0005376 9.17 G6PD HP HPX KIF5B RPTOR CDKN2A

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2
Artesunate Approved, Investigational 88495-63-0 5464098 6917864
3
Ibuprofen Approved 15687-27-1 3672
4 Analgesics
5 Analgesics, Non-Narcotic
6 Anti-Infective Agents
7 Anti-Inflammatory Agents
8 Anti-Inflammatory Agents, Non-Steroidal
9 Antimalarials
10 Antiparasitic Agents
11 Antiprotozoal Agents
12 Antipyretics
13 Antirheumatic Agents
14 Cyclooxygenase Inhibitors
15 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Unknown status NCT01641289 Paracetamol;No Paracetamol

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

38
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 95)
# Title Authors Year
1
Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. ( 29394389 )
2018
2
A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. ( 29338726 )
2018
3
The Multifactorial Epidemiology of Blackwater Fever. ( 29016337 )
2017
4
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. ( 28362936 )
2017
5
An unusual case of blackwater fever. ( 27514973 )
2016
6
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. ( 24629047 )
2014
7
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. ( 23767699 )
2013
8
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. ( 23800033 )
2013
9
Blackwater fever like in murine malaria. ( 23254588 )
2013
10
Blackwater fever: divine retribution or genetic happenstance? ( 20957905 )
2010
11
Blackwater fever: the rise and fall of an exotic disease. ( 20013744 )
2009
12
Blackwater fever in children, Burundi. ( 16022794 )
2005
13
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. ( 14584376 )
2003
14
[Methemalbuminnemia after massive hemolysis during blackwater fever]. ( 12805012 )
2003
15
Blackwater fever treated with artemether. ( 11996443 )
2001
16
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. ( 11283802 )
2001
17
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. ( 10203176 )
1999
18
Recurrence of blackwater fever: triggering of relapses by different antimalarials. ( 9735933 )
1998
19
Blackwater fever: a fatal case. ( 9434932 )
1997
20
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. ( 9402415 )
1997
21
Blackwater fever and acute renal failure in expatriates in Africa. ( 8827999 )
1996
22
Blackwater fever after halofantrine. ( 8637361 )
1996
23
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. ( 8953071 )
1996
24
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. ( 7794063 )
1995
25
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. ( 7859663 )
1994
26
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. ( 3130932 )
1988
27
Drug-induced haemolysis masquerading as blackwater fever. ( 3690650 )
1987
28
Quinine and the mystery of blackwater fever. ( 3321835 )
1987
29
Splenectomy and blackwater fever. ( 7104241 )
1982
30
Blackwater fever in Kenya: problems of etiology. ( 4578485 )
1973
31
Erythrocyte morphology in blackwater fever. ( 5485713 )
1970
32
Autoimmune disease and blackwater fever. ( 4179535 )
1969
33
More blackwater fever. ( 5797772 )
1969
34
Oliguric renal failure in blackwater fever. ( 4881129 )
1968
35
A case of blackwater fever. ( 5661211 )
1968
36
The kidney in blackwater fever: light and electron microscopic observations. ( 4171380 )
1968
37
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. ( 14055154 )
1963
38
The artificial kidney in malaria and blackwater fever. ( 14450615 )
1962
39
Blackwater fever in Southern Rhodesia in retrospect. ( 13975090 )
1962
40
Treatment of blackwater fever with prednisone. ( 13386233 )
1956
41
Blackwater fever in an African child. ( 13261152 )
1955
42
Blackwater fever; its etiology and treatment. ( 13246757 )
1955
43
A fatal case of blackwater fever associated with ingestion of nivaquine. ( 13169242 )
1954
44
BLACKWATER fever; clinical, pathological, and diagnostic features. ( 13076562 )
1953
45
Blackwater fever treated with cortisone. ( 13032514 )
1953
46
Proguanil and blackwater fever. ( 13019138 )
1953
47
Blackwater fever and the intravascular haemolyses. ( 13058138 )
1952
48
Dextran in blackwater fever. ( 13012413 )
1952
49
Blackwater fever apparently precipitated by proguanil. ( 14852178 )
1951
50
Blackwater fever in African children. ( 14830853 )
1951

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 G6PD RPTOR

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 CLIC1 HP HPX
2 endocytic vesicle lumen GO:0071682 8.62 HP HPX

Biological processes related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 8.62 CLIC1 G6PD

Molecular functions related to Blackwater Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 CDKN2A CLIC1 G6PD HP HPX KIF5B

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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