MCID: BLC004
MIFTS: 32

Blackwater Fever malady

Categories: Infectious diseases, Blood diseases

Aliases & Classifications for Blackwater Fever

Aliases & Descriptions for Blackwater Fever:

Name: Blackwater Fever 12 52 42 14 69
Hemoglobinuric, Malaria 12
Malarial Hemoglobinuria 12
Black Water Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14068
ICD9CM 35 084.8
MeSH 42 D001742
NCIt 47 C34426
SNOMED-CT 64 56625005
UMLS 69 C0005681

Summaries for Blackwater Fever

Disease Ontology : 12 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

MalaCards based summary : Blackwater Fever, also known as hemoglobinuric, malaria, is related to malaria and microphthalmia, syndromic 13. An important gene associated with Blackwater Fever is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are Increased shRNA abundance and hematopoietic system

Wikipedia : 71 Blackwater fever is a complication of malaria infection in which red blood cells burst in the... more...

Related Diseases for Blackwater Fever

Diseases related to Blackwater Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 malaria 10.3
2 microphthalmia, syndromic 13 10.2 G6PD HP
3 endometriosis of uterus 10.2 G6PD HP
4 setariasis 10.2 G6PD HP
5 pyeloureteritis cystica 10.2 G6PD HP
6 pyelitis 10.1 G6PD HP
7 facial paresis, hereditary congenital, 1 10.1 HP HPX
8 geniculate ganglionitis 10.1 G6PD HP
9 focal epithelial hyperplasia 10.0 HP HPX
10 hemoglobinuria 10.0
11 meningeal melanocytoma 10.0 G6PD HP
12 idiopathic juvenile osteoporosis 9.9 CDKN2A LRSAM1
13 fallopian tube leiomyosarcoma 9.9 CDKN2A HP
14 anuria 9.9
15 hepatitis 9.9
16 toxic labyrinthitis 8.7 CDKN2A CLIC1 G6PD HP HPX KIF5B

Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to Blackwater Fever

Symptoms & Phenotypes for Blackwater Fever

GenomeRNAi Phenotypes related to Blackwater Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 G6PD HPX KIF5B

MGI Mouse Phenotypes related to Blackwater Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CDKN2A CLIC1 G6PD HP HPX RPTOR
2 homeostasis/metabolism MP:0005376 9.17 CDKN2A CLIC1 G6PD HP HPX KIF5B

Drugs & Therapeutics for Blackwater Fever

Drugs for Blackwater Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2
Ibuprofen Approved 15687-27-1 3672
3
Artesunate Approved 88495-63-0 6917864 5464098
4 Analgesics
5 Cyclooxygenase Inhibitors
6 Analgesics, Non-Narcotic
7 Peripheral Nervous System Agents
8 Anti-Infective Agents
9 Anti-Inflammatory Agents
10 Antimalarials
11 Anti-Inflammatory Agents, Non-Steroidal
12 Antipyretics
13 Antirheumatic Agents
14 Antiparasitic Agents
15 Antiprotozoal Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria Active, not recruiting NCT01641289

Search NIH Clinical Center for Blackwater Fever

Cochrane evidence based reviews: blackwater fever

Genetic Tests for Blackwater Fever

Anatomical Context for Blackwater Fever

MalaCards organs/tissues related to Blackwater Fever:

39
Kidney

Publications for Blackwater Fever

Articles related to Blackwater Fever:

(show top 50) (show all 91)
id Title Authors Year
1
An unusual case of blackwater fever. ( 27514973 )
2016
2
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. ( 24629047 )
2014
3
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. ( 23767699 )
2013
4
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. ( 23800033 )
2013
5
Blackwater fever like in murine malaria. ( 23254588 )
2013
6
Blackwater fever: divine retribution or genetic happenstance? ( 20957905 )
2010
7
Blackwater fever: the rise and fall of an exotic disease. ( 20013744 )
2009
8
Blackwater fever in children, Burundi. ( 16022794 )
2005
9
[Methemalbuminnemia after massive hemolysis during blackwater fever]. ( 12805012 )
2003
10
Epidemiological and clinical aspects of blackwater fever among African children suffering frequent malaria attacks. ( 14584376 )
2003
11
Blackwater fever treated with artemether. ( 11996443 )
2001
12
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review. ( 11283802 )
2001
13
Acute intravascular haemolysis (blackwater fever) after antimalarial treatment. ( 10203176 )
1999
14
Recurrence of blackwater fever: triggering of relapses by different antimalarials. ( 9735933 )
1998
15
Blackwater fever: a fatal case. ( 9434932 )
1997
16
The role of glucose-6-phosphate dehydrogenase deficiency in blackwater fever. ( 9402415 )
1997
17
Blackwater fever after halofantrine. ( 8637361 )
1996
18
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. ( 8953071 )
1996
19
Blackwater fever and acute renal failure in expatriates in Africa. ( 8827999 )
1996
20
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. ( 7794063 )
1995
21
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. ( 7859663 )
1994
22
Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. ( 3130932 )
1988
23
Drug-induced haemolysis masquerading as blackwater fever. ( 3690650 )
1987
24
Quinine and the mystery of blackwater fever. ( 3321835 )
1987
25
Splenectomy and blackwater fever. ( 7104241 )
1982
26
Blackwater fever in Kenya: problems of etiology. ( 4578485 )
1973
27
Erythrocyte morphology in blackwater fever. ( 5485713 )
1970
28
More blackwater fever. ( 5797772 )
1969
29
Autoimmune disease and blackwater fever. ( 4179535 )
1969
30
Oliguric renal failure in blackwater fever. ( 4881129 )
1968
31
The kidney in blackwater fever: light and electron microscopic observations. ( 4171380 )
1968
32
A case of blackwater fever. ( 5661211 )
1968
33
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE. ( 14055154 )
1963
34
The artificial kidney in malaria and blackwater fever. ( 14450615 )
1962
35
Blackwater fever in Southern Rhodesia in retrospect. ( 13975090 )
1962
36
Treatment of blackwater fever with prednisone. ( 13386233 )
1956
37
Blackwater fever; its etiology and treatment. ( 13246757 )
1955
38
Blackwater fever in an African child. ( 13261152 )
1955
39
A fatal case of blackwater fever associated with ingestion of nivaquine. ( 13169242 )
1954
40
BLACKWATER fever; clinical, pathological, and diagnostic features. ( 13076562 )
1953
41
Proguanil and blackwater fever. ( 13019138 )
1953
42
Blackwater fever treated with cortisone. ( 13032514 )
1953
43
Dextran in blackwater fever. ( 13012413 )
1952
44
Blackwater fever and the intravascular haemolyses. ( 13058138 )
1952
45
Blackwater fever in African children. ( 14830853 )
1951
46
Observations on the mechanism of haemolysis in blackwater fever. ( 14908092 )
1951
47
BLACKWATER fever. ( 14848575 )
1951
48
Blackwater fever apparently precipitated by proguanil. ( 14852178 )
1951
49
Observations on the mechanism of blackwater fever; an experimental study in the monkey. ( 14804092 )
1950
50
A heretofore unreported agglutinable human blood factor and its possible relationship to blackwater fever. ( 14771390 )
1950

Variations for Blackwater Fever

Expression for Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for Blackwater Fever

Pathways related to Blackwater Fever according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.55 G6PD RPTOR

GO Terms for Blackwater Fever

Cellular components related to Blackwater Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.13 CLIC1 HP HPX
2 endocytic vesicle lumen GO:0071682 8.62 HP HPX

Molecular functions related to Blackwater Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 CDKN2A CLIC1 G6PD HP HPX KIF5B

Sources for Blackwater Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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