MCID: BLC004
MIFTS: 40

Blackwater Fever malady

Infectious diseases, Blood diseases categories

Summaries for Blackwater Fever

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with plasmodium falciparum or plasmodium vivax.

MalaCards: Blackwater Fever, also known as hemoglobinuric, malaria, is related to malaria and hemoglobinuria. An important gene associated with Blackwater Fever is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways is Binding and Uptake of Ligands by Scavenger Receptors. The compounds thiobarbituric acid and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Wikipedia:66 (see PMID 23402997 and PMID 22931368) more...

Aliases & Classifications for Blackwater Fever

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Blood diseases


Aliases & Descriptions:

blackwater fever 9 11 46 63
hemoglobinuric, malaria 9
malarial hemoglobinuria 9
black water fever 9


External Ids:

Disease Ontology9 DOID:14068
ICD9CM28 084.8
SNOMED-CT59 56625005
NCIt41 C34426
MeSH36 D001742

Related Diseases for Blackwater Fever

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Blackwater Fever:



Diseases related to blackwater fever

Symptoms for Blackwater Fever

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Drugs & Therapeutics for Blackwater Fever

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Blackwater Fever

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Anatomical Context for Blackwater Fever

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Sources:
34MalaCards
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MalaCards organs/tissues related to Blackwater Fever:

34
Kidney

Animal Models for Blackwater Fever or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Blackwater Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0KIF5B, HPX, HP, G6PD
2MP:00053767.7KIF5B, HPX, HP, G6PD

Publications for Blackwater Fever

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53PubMed
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Articles related to Blackwater Fever:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. (23767699)
2013
2
Blackwater fever like in murine malaria. (23254588)
2013
3
Blackwater fever: the rise and fall of an exotic disease. (20013744)
2009
4
Blackwater fever treated with artemether. (11996443)
2001
5
Recurrence of blackwater fever: triggering of relapses by different antimalarials. (9735933)
1998
6
Blackwater fever after halofantrine. (8637361)
1996
7
Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. (8953071)
1996
8
Blackwater fever at the Kenyatta National Hospital in Kenya: a case report. (7859663)
1994
9
Quinine and the mystery of blackwater fever. (3321835)
1987
10
Erythrocyte morphology in blackwater fever. (5485713)
1970
11
A case of blackwater fever. (5661211)
1968
12
Oliguric renal failure in blackwater fever. (4881129)
1968
13
Blackwater fever in Southern Rhodesia in retrospect. (13975090)
1962
14
The artificial kidney in malaria and blackwater fever. (14450615)
1962
15
Treatment of blackwater fever with prednisone. (13386233)
1956
16
Blackwater fever in an African child. (13261152)
1955
17
Blackwater fever; its etiology and treatment. (13246757)
1955
18
A fatal case of blackwater fever associated with ingestion of nivaquine. (13169242)
1954
19
BLACKWATER fever; clinical, pathological, and diagnostic features. (13076562)
1953
20
Blackwater fever and the intravascular haemolyses. (13058138)
1952
21
Dextran in blackwater fever. (13012413)
1952
22
BLACKWATER fever. (14848575)
1951
23
A heretofore unreported agglutinable human blood factor and its possible relationship to blackwater fever. (14771390)
1950
24
Blackwater fever in West Africa, 1941-45; blackwater fever in European military personnel. (15393586)
1949
25
Proguanil and blackwater fever. (18224799)
1949
26
Blackwater fever in West Africa; 1941-45; blackwater fever in African military personnel. (15393593)
1949
27
Attempts to induce blackwater fever experimentally. (20249286)
1947
28
A hepatic syndrome of wide distribution illustrated by lesions in malaria and blackwater fever. (20272628)
1947
29
Blackwater fever; modern theories; a critical review. (21003289)
1946
30
A case of blackwater fever observed in Britain. (20999638)
1946
31
Autoantigens and autoantibodies in the pathogenesis of disease with special refenence to blackwater fever. (21020353)
1945-1946
32
On a fatal case of blackwater fever with pseudo-methaemoglobinemia. (21028572)
1945
33
Blackwater Fever in West Africa. (20785946)
1945
34
Report of an attack of blackwater fever subsequent to induced malaria. (21005332)
1945
35
Survival of transfused red cells in blackwater fever circulation and of blackwater red cells in normal circulation (preliminary report). (20293958)
1945
36
A case of blackwater fever in an African girl. (20293964)
1945
37
BLACKWATER FEVER. (20780859)
1937
38
THE MECHANISM OF BLACKWATER FEVER AND CERTAIN ALLIED CONDITIONS. (20774047)
1928
39
SOME OBSERVATIONS ON BLACKWATER FEVER. (20771869)
1925
40
BLACKWATER FEVER: ITS ETIOLOGY AND PARASITOLOGY. (20771378)
1923
41
A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER. (20770160)
1921
42
Blackwater Fever. (20474711)
1920
43
A REPUTED SPECIFIC FOR BLACKWATER FEVER. (17817189)
1916
44
A Case of Blackwater Fever in England. (20765693)
1911
45
NOTES ON A CASE OF QUININE HAEMOGLOBINURIA OR BLACKWATER FEVER. (20762926)
1906
46
EXPERIMENTAL HAEMOGLOBINURIA IN A CASE OF BLACKWATER FEVER. (20760898)
1903
47
BLACKWATER FEVER. (20760014)
1902
48
Observations on Blackwater Fever. (20759804)
1901
49
Five Cases of So-Called Blackwater Fever. (20758589)
1899
50
African Haemoglobinuric Fever, Commonly Called Blackwater Fever. (20758062)
1898

Variations for Blackwater Fever

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Expression for genes affiliated with Blackwater Fever

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blackwater Fever

Search GEO for disease gene expression data for Blackwater Fever.

Pathways for genes affiliated with Blackwater Fever

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51PathCards, 56Reactome
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Pathways related to Blackwater Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3HPX, HP

Compounds for genes affiliated with Blackwater Fever

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 3BitterDB
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Compounds related to Blackwater Fever according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid469.7HP, G6PD
223-diphosphoglycerate469.7HP, G6PD
3zinc protoporphyrin469.7G6PD, HP
4cyanide46 2510.7HPX, HP
5protoporphyrin ix46 25 1211.7HPX, HP
6tocopherol469.7G6PD, HP
7starch469.7HP, G6PD
8cellulose acetate469.7HP, G6PD
9sulfasalazine30 46 52 1212.7HP, G6PD
10lactose46 1210.7HP, G6PD
11ribavirin46 52 1211.7HP, G6PD
12vitamin b12469.7G6PD, HP
13malondialdehyde469.7HP, G6PD
14uric acid46 2510.7G6PD, HP
15chloroquine46 3 52 30 1213.6HP, G6PD
16polyethylene glycol469.6HP, G6PD
17glucose 6-phosphate46 2510.6G6PD, HP
18vitamin-e469.6G6PD, HP
19citrate469.6G6PD, HP
20agarose469.6HPX, HP
21thyroxine46 2510.6HP, G6PD
22hyaluronic acid46 2510.6HPX, HP
23folate469.5G6PD, HP
24nacl469.5HPX, HP
25vitamin a46 25 1211.4HPX, HP
26aspirin46 52 30 2512.4G6PD, HP
27epinephrine46 25 1211.3HP, G6PD
28vitamin d469.3HPX, HP
29ascorbic acid46 2510.2HPX, HP, G6PD
30h2o2469.2G6PD, HP, HPX
31polysaccharide469.0HPX, HP
32serine468.7G6PD, HP, HPX
33lipid468.7KIF5B, HP, G6PD
34atp46 309.4KIF5B, HPX, HP, G6PD

GO Terms for genes affiliated with Blackwater Fever

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17Gene Ontology
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Cellular components related to Blackwater Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.2HPX, HP
2blood microparticleGO:0725629.0HPX, HP
3extracellular vesicular exosomeGO:0700628.8HPX, HP, G6PD

Products for genes affiliated with Blackwater Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blackwater Fever

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet