Bladder Cancer, Somatic malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Nephrological diseases
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 31ICD9CM, 34LifeMap Discovery®, 36MedGen, 37MedlinePlus, 38MeSH, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 69UniProtKB/Swiss-Prot
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Aliases & Descriptions for Bladder Cancer, Somatic:
bladder cancer, somatic:
Inheritance: autosomal dominant inheritance
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Nephrological diseases
MedlinePlus:37 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute
MalaCards based summary: Bladder Cancer, Somatic, also known as bladder cancer, is related to papilloma and prostate cancer, and has symptoms including transitional cell carcinoma of the bladder An important gene associated with Bladder Cancer, Somatic is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Vemurafenib Pathway, Pharmacodynamics and MNAR-PELP1 and Estrogen Receptor Interaction. The drugs cisplatin and carboplatin have been mentioned in the context of this disorder. Affiliated tissues include the urinary bladder, prostate and lung, and related mouse phenotypes are pigmentation and limbs/digits/tail.
Disease Ontology:11 An urinary system cancer that results in malignant growth located in the urinary bladder.
Genetics Home Reference:25 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).
NIH Rare Diseases:47 Bladder cancer is a form of cancer that occurs due to abnormal and uncontrolled cell growth in the bladder. Signs and symptoms of the condition may include abdominal pain, blood in the urine, fatigue, painful urination, frequent urination, incontinence, and/or weightloss. Most cases of bladder cancer occur sporadically in people with no family history of the condition. Risk factors for the condition include smoking, exposure to certain chemicals, and having chronic bladder infections. Treatment varies based on the severity of the condition and may include surgery, radiation therapy, chemotherapy, and/or biological therapy. Last updated: 11/11/2015
UniProtKB/Swiss-Prot:69 Bladder cancer: A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas that begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
Description from OMIM:51 109800
FDA approved drugs:
Drugs for Bladder Cancer, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 548)
Interventional clinical trials:(show top 50) (show all 1102)
Search NIH Clinical Center for Bladder Cancer, Somatic
Inferred drug relations via UMLS67/NDF-RT45:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bladder Cancer, Somatic cell therapies at LifeMap Discovery.
MalaCards organs/tissues related to Bladder Cancer, Somatic:35
Prostate, Lung, Testes, Lymph node, Kidney, Spinal cord, Breast
FMA organs/tissues related to Bladder Cancer, Somatic:17
The urinary bladder
MGI Mouse Phenotypes related to Bladder Cancer, Somatic:40 (show all 27)
UniProtKB/Swiss-Prot genetic disease variations for Bladder Cancer, Somatic:69
Clinvar genetic disease variations for Bladder Cancer, Somatic:5
Cosmic variations for Bladder Cancer, Somatic:8
Copy number variations for Bladder Cancer, Somatic from CNVD:6 (show top 50) (show all 98)
Search GEO for disease gene expression data for Bladder Cancer, Somatic.
Pathways related to Bladder Cancer, Somatic according to KEGG:33
Pathways related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:(show all 44)
Cellular components related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:
Biological processes related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:(show all 17)
Molecular functions related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet