Bladder Cancer, Somatic malady
Genetic diseases, Rare diseases, Cancer diseases, Nephrological diseases categories
Aliases & Descriptions for Bladder Cancer, Somatic:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Nephrological diseases
NIH Rare Diseases:45 Bladder cancer is cancer that affects the bladder. the bladder is a hollow organ in the lower part of the abdomen that stores urine until it is passed out of the body. the most common type of bladder cancer is transitional cell carcinoma, which begins in urothelial cells that line the inside of the bladder. urothelial cells are transitional cells, which are able to change shape and stretch when the bladder is full. this type of cancer is also called urothelial carcinoma. people who smoke or are exposed to certain chemicals or have chronic bladder infections have an increased risk of bladder cancer. the most common sign of bladder cancer is blood in the urine. bladder cancer is often diagnosed at an early stage, when the cancer is easier to treat. a staging system is a standard way for members of the cancer care team to describe the extent of cancer spread. bladder cancers that have not invaded the bladder muscle layer (t1) are grouped as non– muscle-invasive bladder cancer (nmibc). stage t2 cancers are muscle invasive, and higher stage cancers invade beyond the muscle layer into surrounding fat (stage classification t3 bladder cancer) or beyond the fat into nearby organs or structures (stage classification t4 bladder cancer). treatment depends in the stage of the cancer. last updated: 10/30/2015
MalaCards based summary: Bladder Cancer, Somatic, also known as bladder cancer, is related to cell type cancer and hepatocellular carcinoma, and has symptoms including autosomal dominant inheritanceand transitional cell carcinoma of the bladder. An important gene associated with Bladder Cancer, Somatic is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are Transcriptional activation of p53 responsive genes and Vemurafenib Pathway, Pharmacodynamics. The drugs cisplatin and etoposide phosphate have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and craniofacial.
Disease Ontology:10 A urinary bladder cancer that has material basis in abnormally proliferating cells derives from epithelial cells.
Genetics Home Reference:23 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).
MedlinePlus:35 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute
UniProtKB/Swiss-Prot:67 Bladder cancer: A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas that begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
Description from OMIM:49 109800
FDA approved drugs:
Drugs for Bladder Cancer, Somatic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 314)
Interventional clinical trials:(show top 50) (show all 955)
Search NIH Clinical Center for Bladder Cancer, Somatic
Inferred drug relations via UMLS65/NDF-RT43:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bladder Cancer, Somatic cell therapies at LifeMap Discovery.
MGI Mouse Phenotypes related to Bladder Cancer, Somatic:38 (show all 25)
UniProtKB/Swiss-Prot genetic disease variations for Bladder Cancer, Somatic:67
Clinvar genetic disease variations for Bladder Cancer, Somatic:5
Cosmic variations for Bladder Cancer, Somatic:7 (show top 50) (show all 8210)
Search GEO for disease gene expression data for Bladder Cancer, Somatic.
Pathways related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:(show top 50) (show all 58)
Cellular components related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:
Biological processes related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:(show all 23)
Molecular functions related to Bladder Cancer, Somatic according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet