MCID: BLD042
MIFTS: 66

Bladder Carcinoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Bladder Carcinoma

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Sources:
9Disease Ontology, 22Genetics Home Reference, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Bladder Carcinoma, also known as bladder cancer, is related to bladder carcinoma in situ and lung cancer. An important gene associated with Bladder Carcinoma is SLC7A5 (solute carrier family 7 (amino acid transporter light chain, L system), member 5). The drugs thiotepa and cisplatin and the compounds hpaii and scca1 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lymph node and prostate, and related mouse phenotype mortality/aging.

Disease Ontology:9 A urinary bladder cancer that arises from tissues of the bladder.

Genetics Home Reference:22 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).

Wikipedia:66 Bladder cancer is any of several types of cancer arising from the epithelial lining (i.e., the... more...

Description from OMIM:48 109800

Aliases & Classifications for Bladder Carcinoma

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Sources:
9Disease Ontology, 66Wikipedia, 23GTR, 22Genetics Home Reference, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

bladder carcinoma 9 46 32
bladder cancer 9 66 22 46 35
urinary bladder cancer 9 66 22 11
malignant tumor of urinary bladder 66 23 22
cancer of the bladder 66 22
carcinoma of bladder 9 63
carcinoma of urinary bladder 9
tumor of the bladder 9
carcinoma bladder 9
bladder neoplasm 63
bladder tumors 46


Related Diseases for Bladder Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Bladder Carcinoma family:

Bladder Carcinoma in Situ Bladder Benign Neoplasm

Diseases related to Bladder Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma in situ31.1UPK3A, UPK2, FGFR3
2lung cancer30.1MUC2, SERPINB5, SERPINB2, H19, UPK2, JUP
3transitional cell carcinoma30.1NUDT6, JUP, PSCA, UPK3A, UPK2, H19
4breast cancer30.0SERPINB5, SERPINB2, JUP, MUC2, H19
5sarcoma29.9SERPINB5, SERPINB2, JUP
6cervical cancer29.8FGFR3, JUP, H19
7adenocarcinoma29.8H19, PSCA, TDGF1P3, CGB7, NUDT6, SERPINB5
8adenoma29.8JUP, SERPINB5, H19, TDGF1P3, CGB7, NUDT6
9ovarian cancer29.7JUP, SERPINB5, SERPINB2, MUC2
10stomach cancer29.7SERPINB2, SERPINB5, JUP, MUC2, ANG
11melanoma29.6BAGE, JUP, SERPINB2, SERPINB5, ANG, NUDT6
12colorectal cancer29.5SERPINB5, SERPINB2, MUC2, JUP, ANG, H19
13prostate cancer29.5FGFR3, ANG, PSCA, MUC2, JUP, SERPINB2
14small cell carcinoma10.5
15endotheliitis10.4
16amyloid tumor10.4
17inflammatory myofibroblastic tumor10.4
18prostatitis10.4
19hydronephrosis10.4
20bladder cancer susceptibility10.3
21neuroendocrine carcinoma10.3
22verrucous carcinoma10.3
23hepatitis10.3
24retinoblastoma10.3
25diphtheria10.3
26granulomatous hepatitis10.2
27leukemoid reaction10.2
28cystitis10.2
29perivascular epithelioid cell tumor10.2
30granular cell tumor10.2
31bacteriuria10.2
32gallbladder cancer10.2
33leukemia10.2
34tuberculosis10.2
35orchitis10.2
36bladder transitional cell carcinoma10.2
37epididymo-orchitis10.2
38hypoxia10.2
39urinary bladder small cell neuroendocrine carcinoma10.2
40large cell neuroendocrine carcinoma10.2
41lymphoepithelioma-like carcinoma10.2
42pernicious anemia10.2
43inverted papilloma10.2
44non-hodgkin lymphoma10.2
45acute febrile neutrophilic dermatosis10.2
46spinal cord injury10.2
47hinman syndrome10.2
48urachal cancer10.1
49ovarian brenner tumor10.1UPK3A
50cerebritis10.1

Graphical network of the top 20 diseases related to Bladder Carcinoma:



Diseases related to bladder carcinoma

Symptoms for Bladder Carcinoma

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Sources:
48OMIM
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Clinical features from OMIM:

109800

Drugs & Therapeutics for Bladder Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bladder Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bladder Carcinoma

Search NIH Clinical Center for Bladder Carcinoma

Search CenterWatch for Bladder Carcinoma

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Carcinoma:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Carcinoma:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Carcinoma

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23GTR
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Genetic tests related to Bladder Carcinoma:

id Genetic test Affiliating Genes
1 Malignant Tumor of Urinary Bladder23

Anatomical Context for Bladder Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Bladder Carcinoma:

34
Endothelial, Lymph node, Prostate, Testes, Bone, T cells, Brain, Lung, Colon, Monocytes, Nk cells, Kidney, Spinal cord, Smooth muscle

Animal Models for Bladder Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bladder Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8FGFR3, SLC7A5, H19, UPK2, MUC2, JUP

Publications for Bladder Carcinoma

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Sources:
53PubMed
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Articles related to Bladder Carcinoma:

(show top 50)    (show all 759)
idTitleAuthorsYear
1
BK virus-associated urinary bladder carcinoma in transplant recipients: productive or nonproductive polyomavirus infections in tumor cells? (24262020)
2013
2
Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. (23153706)
2013
3
The diagnostic accuracy of multidetector computed tomography with multiplanar reformatted imaging and virtual cystoscopy in the early detection and evaluation of bladder carcinoma: comparison with conventional cystoscopy. (22623028)
2013
4
ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma. (23333248)
2013
5
Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma. (21956756)
2012
6
Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma. (22914320)
2012
7
Urinary tumor marker in bladder carcinoma in Upper Egypt, correlations with different clinicopathological features. (22982928)
2012
8
The varying faces of gall bladder carcinoma: pictorial essay. (22547386)
2012
9
Clinical usefulness of CEA, CA19-9, and CYFRA 21-1 as tumor markers for urothelial bladder carcinoma. (22041857)
2011
10
Second resection for non-muscle-invasive bladder carcinoma: current role and future perspectives. (20427121)
2010
11
External beam radiotherapy of bladder carcinoma: considerations in determining the irradiation field margins. (20941815)
2010
12
Editorial comment on: prognostic accuracy of individual uropathologists in noninvasive urinary bladder carcinoma: a multicentre study comparing the 1973 and 2004 World Health Organisation classifications. (19346064)
2010
13
New insights in intravesical treatment for intermediate- and high-risk non-muscle-invasive urothelial bladder carcinoma. (20080332)
2010
14
Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP. (18835089)
2009
15
Bladder carcinoma presenting during twin pregnancy. (19065377)
2008
16
Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. (18413799)
2008
17
Sensitivity and specificity of p53 protein detection by immunohistochemistry in patients with urothelial bladder carcinoma. (18025850)
2007
18
Erysipeloid cutaneous metastasis from bladder carcinoma. (17951136)
2007
19
Penoscrotal histoplasmosis following bladder carcinoma. (17593111)
2007
20
The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells. (17348027)
2007
21
Low prevalence of Helicobacteraceae in gall-stone disease and gall-bladder carcinoma in the German population. (17346303)
2007
22
Primary small cell bladder carcinoma: a case report and review of the current literature. (17260501)
2006
23
Pseudoaneurysm embolization and vasopressin infusion for lower gastrointestinal bleeding due to recurrence of urinary bladder carcinoma. (16958402)
2006
24
Proliferating cell nuclear antigen (PCNA) overexpression and microvessel density predict survival in the urinary bladder carcinoma. (16868689)
2006
25
Bladder carcinoma and HIV infection during the highly active antiretroviral therapy era: A rare, but intriguing association. Two case reports and literature review. (16798716)
2006
26
Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: relationship with clinical course at 10 years follow-up. (15944797)
2005
27
Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-GuAcrin treatment. (16037714)
2005
28
P16 immunoreactivity is an independent predictor of tumor progression in minimally invasive urothelial bladder carcinoma. (15774242)
2005
29
Staging bladder carcinoma by three-dimensional ultrasound rendering. (15749550)
2005
30
Papillary urothelial bladder carcinoma associated with osteoclast-like giant cells. (16132761)
2005
31
Bladder carcinoma in situ in 2003: state of the art. (14733997)
2004
32
The expression and significance of survivin mRNA in urinary bladder carcinomas. (15138808)
2004
33
Detection of telomerase status by semiquantitative and in situ assays, and by real-time reverse transcription-polymerase chain reaction (telomerase reverse transcriptase) assay in bladder carcinomas. (12656916)
2003
34
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. (14532840)
2003
35
The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. (12239635)
2002
36
PSCA expression is regulated by phorbol ester and cell adhesion in the bladder carcinoma cell line RT112. (11368875)
2001
37
Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. (11559536)
2001
38
Expression of pS2 protein and its relation with the Ki-67 proliferative indices and tumor recurrence in superficial bladder carcinomas. (11528193)
2001
39
Chemosensitization of bladder carcinoma cells by bcl-xL antisense oligonucleotides. (11458048)
2001
40
Noninvasive diagnosis of bladder carcinoma by enzyme-linked immunosorbent assay detection of CD44 isoforms in exfoliated urothelia. (10873090)
2000
41
Epidermal growth factor receptor (EGFR) in the prognosis of bladder carcinoma. Experience of 5 years]. (10900762)
2000
42
Expression of cytokeratin 20 in urinary cytology of patients with bladder carcinoma. (9731913)
1998
43
Expression of three cell adhesion molecules in bladder carcinomas: correlation with pathological features. (9223755)
1997
44
Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas. (9192977)
1997
45
Expression of human chorionic gonadotropin beta subunit genes in superficial and invasive bladder carcinomas. (7543817)
1995
46
Expression and secretion of the beta subunit of human chorionic gonadotropin by bladder carcinoma in vivo and in vitro. (7882356)
1995
47
HPV and p53 in urinary bladder carcinoma. (7808793)
1994
48
neu is not involved in N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder carcinoma or 2-amino-4-(5-nitro-2-furyl)thiazole transformation of rat bladder epithelial cells. (7915641)
1994
49
Eosinophilic cystitis simulating invasive bladder carcinoma. (8351485)
1993
50
Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma. (1759330)
1991

Variations for Bladder Carcinoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Bladder Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenicrs104894230GRCh37Chr 11, 534288: 534288
2FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568

Expression for genes affiliated with Bladder Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Carcinoma

Search GEO for disease gene expression data for Bladder Carcinoma.

Pathways for genes affiliated with Bladder Carcinoma

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Compounds for genes affiliated with Bladder Carcinoma

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Sources:
46Novoseek, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 12DrugBank
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Compounds related to Bladder Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1hpaii4610.1H19, MUC2
2scca14610.0SERPINB5, SERPINB2
3cytosine46 2510.8H19, SERPINB2, SERPINB5
4ribonucleic acid469.7SERPINB2, H19, NUDT6
5matrigel469.5SERPINB2, NUDT6, SERPINB5
6agar469.2JUP, NUDT6, H19, TDGF1P3
75-aza-2deoxycytidine469.1JUP, H19, MUC2, SERPINB5, BAGE
8progesterone46 30 62 25 1213.1SERPINB5, SERPINB2, MUC2, CGB7
9paraffin469.1H19, JUP, SERPINB2, SERPINB5, FGFR3, MUC2
10steroid469.0SERPINB2, H19, NUDT6, SERPINB5
11cysteine469.0NUDT6, SLC7A5, MUC2, CGB7, FGFR3
12tyrosine468.8NUDT6, FGFR3, SLC7A5, H19, ANG, JUP
13vegf468.8SERPINB5, FGFR3, SLC7A5, ANG, JUP, SERPINB2
14serine468.7SLC7A5, NUDT6, MUC2, JUP, SERPINB2, SERPINB5
15retinoic acid46 259.2NUDT6, SERPINB2, JUP, MUC2, H19, TDGF1P3

GO Terms for genes affiliated with Bladder Carcinoma

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17Gene Ontology
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Cellular components related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.9FGFR3, JUP
2apical plasma membraneGO:0163248.9SLC7A5, UPK2, UPK3A

Biological processes related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of proteolysisGO:0301629.9SERPINB2, SERPINB5
2morphogenesis of an epitheliumGO:0020099.6FGFR3, SERPINB5

Products for genes affiliated with Bladder Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet