MCID: BLD042
MIFTS: 68

Bladder Carcinoma malady

Cancer diseases, Nephrological diseases categories
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Summaries for Bladder Carcinoma

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MedlinePlus:33 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards based summary: Bladder Carcinoma, also known as urinary bladder cancer, is related to bladder carcinoma in situ and gallbladder cancer. An important gene associated with Bladder Carcinoma is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways is MicroRNAs in cancer. The drugs bcg vaccine and cisplatin and the compounds scca1 and hpaii have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and prostate, and related mouse phenotypes are tumorigenesis and mortality/aging.

Disease Ontology:8 A urinary bladder cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

Genetics Home Reference:21 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).

Wikipedia:65 Bladder cancer is any of several types of cancer arising from the epithelial lining (i.e., the... more...

Description from OMIM:46 109800

Aliases & Classifications for Bladder Carcinoma

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Bladder Carcinoma, Aliases & Descriptions:

Name: Bladder Carcinoma 30 8 44
Urinary Bladder Cancer 8 65 21 10 62
Bladder Cancer 8 65 21 44 33
Malignant Tumor of Urinary Bladder 65 22 21 62
Cancer of the Bladder 65 21 62
Carcinoma of Urinary Bladder 8 62
 
Carcinoma of Bladder 8 62
Tumor of the Bladder 8 62
Carcinoma Bladder 8
Bladder Neoplasm 62
Bladder Tumors 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Related Diseases for Bladder Carcinoma

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Diseases in the Bladder Carcinoma family:

Bladder Carcinoma in Situ Bladder Benign Neoplasm

Diseases related to Bladder Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma in situ31.1UPK3A, UPK2, KRT20, HRAS, FGFR3
2gallbladder cancer30.7HRAS, MUC2
3lung cancer30.6HRAS, KRT20, BAGE, H19
4papilloma30.2FGFR3, HRAS, KRT20
5cervical cancer30.1JUP, H19, CGB7, FGFR3
6sarcoma30.0SERPINB5, SERPINB2, JUP, HRAS
7papillary carcinoma30.0SERPINB5, MUC2, KRT20, HRAS
8breast cancer30.0SERPINB5, SERPINB2, JUP, MUC2, H19, KRT20
9transitional cell carcinoma29.9NUDT6, JUP, PSCA, UPK3A, UPK2, H19
10prostate cancer29.9SERPINB5, JUP, PSCA, HRAS
11leukemia29.9NUDT6, SERPINB2, H19, HRAS, FGFR3
12ovarian cancer29.8SERPINB5, SERPINB2, JUP, MUC2, KRT20
13stomach cancer29.7SERPINB5, SERPINB2, JUP, MUC2, ANG, KRT20
14adenoma29.4NUDT6, SERPINB5, JUP, MUC2, H19, KRT20
15melanoma29.4NUDT6, SERPINB5, SERPINB2, JUP, ANG, BAGE
16adenocarcinoma29.2KRT20, TDGF1P3, HRAS, CGB7, H19, UPK3A
17colorectal cancer29.0SERPINB5, SERPINB2, JUP, MUC2, ANG, H19
18small cell carcinoma10.5
19inflammatory myofibroblastic tumor10.4
20neuroendocrine carcinoma10.4
21verrucous carcinoma10.4
22ovarian brenner tumor10.4UPK3A, KRT20
23signet ring cell adenocarcinoma10.4MUC2, KRT20
24bladder cancer susceptibility10.4
25endotheliitis10.4
26amyloid tumor10.4
27pancreatic ductal carcinoma10.4KRT20, MUC2
28prostatitis10.4
29vesicoureteral reflux10.4UPK2, UPK3A
30hydronephrosis10.4
31pseudomyxoma peritonei10.4KRT20, MUC2
32gallbladder disease10.4MUC2, SERPINB2
33keratosis10.4JUP
34urinary bladder small cell neuroendocrine carcinoma10.3
35large cell neuroendocrine carcinoma10.3
36tubular adenocarcinoma10.3MUC2, KRT20
37microinvasive gastric cancer10.3MUC2, JUP
38hepatitis10.3
39retinoblastoma10.3
40adenosquamous carcinoma10.3MUC2, KRT20
41gestational trophoblastic neoplasm10.3CGB7, H19
42pancreatitis, chronic10.3SERPINB5, MUC2, PSCA
43bronchiolo-alveolar adenocarcinoma10.3JUP, MUC2, KRT20
44diphtheria10.3
45tuberculosis10.3
46pancreatic cancer10.3PSCA, MUC2, SERPINB5
47seminoma10.3CGB7, H19, JUP
48granulomatous hepatitis10.3
49leukemoid reaction10.3
50cystitis10.3

Graphical network of the top 20 diseases related to Bladder Carcinoma:



Diseases related to bladder carcinoma

Symptoms for Bladder Carcinoma

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Clinical features from OMIM:

109800

Drugs & Therapeutics for Bladder Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Bladder Carcinoma

Search NIH Clinical Center for Bladder Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Carcinoma:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Carcinoma:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Carcinoma

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Genetic tests related to Bladder Carcinoma:

id Genetic test Affiliating Genes
1 Malignant Tumor of Urinary Bladder22

Anatomical Context for Bladder Carcinoma

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MalaCards organs/tissues related to Bladder Carcinoma:

32
Lymph node, Endothelial, Prostate, Testes, Bone, Brain, Lung, T cells, Spinal cord, Smooth muscle, Colon, Kidney, Monocytes, Nk cells, Neutrophil

Animal Models for Bladder Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Bladder Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3FGFR3, HRAS, H19, PSCA, MUC2
2MP:00107688.6SERPINB2, JUP, MUC2, UPK2, H19, HRAS

Publications for Bladder Carcinoma

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Articles related to Bladder Carcinoma:

(show top 50)    (show all 781)
idTitleAuthorsYear
1
Reduction of bladder activity on FDG PET/CT scan in patients with urinary bladder carcinoma. A prospective study with a patient-friendly protocol. (25345433)
2014
2
BK virus-associated urinary bladder carcinoma in transplant recipients: productive or nonproductive polyomavirus infections in tumor cells? (24262020)
2013
3
Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. (23153706)
2013
4
The diagnostic accuracy of multidetector computed tomography with multiplanar reformatted imaging and virtual cystoscopy in the early detection and evaluation of bladder carcinoma: comparison with conventional cystoscopy. (22623028)
2013
5
ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma. (23333248)
2013
6
Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma. (21956756)
2012
7
Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma. (22914320)
2012
8
Urinary tumor marker in bladder carcinoma in Upper Egypt, correlations with different clinicopathological features. (22982928)
2012
9
The varying faces of gall bladder carcinoma: pictorial essay. (22547386)
2012
10
Clinical usefulness of CEA, CA19-9, and CYFRA 21-1 as tumor markers for urothelial bladder carcinoma. (22041857)
2011
11
Second resection for non-muscle-invasive bladder carcinoma: current role and future perspectives. (20427121)
2010
12
External beam radiotherapy of bladder carcinoma: considerations in determining the irradiation field margins. (20941815)
2010
13
Editorial comment on: prognostic accuracy of individual uropathologists in noninvasive urinary bladder carcinoma: a multicentre study comparing the 1973 and 2004 World Health Organisation classifications. (19346064)
2010
14
New insights in intravesical treatment for intermediate- and high-risk non-muscle-invasive urothelial bladder carcinoma. (20080332)
2010
15
Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP. (18835089)
2009
16
Bladder carcinoma presenting during twin pregnancy. (19065377)
2008
17
Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. (18413799)
2008
18
Sensitivity and specificity of p53 protein detection by immunohistochemistry in patients with urothelial bladder carcinoma. (18025850)
2007
19
Erysipeloid cutaneous metastasis from bladder carcinoma. (17951136)
2007
20
Penoscrotal histoplasmosis following bladder carcinoma. (17593111)
2007
21
The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells. (17348027)
2007
22
Primary small cell bladder carcinoma: a case report and review of the current literature. (17260501)
2006
23
Pseudoaneurysm embolization and vasopressin infusion for lower gastrointestinal bleeding due to recurrence of urinary bladder carcinoma. (16958402)
2006
24
Proliferating cell nuclear antigen (PCNA) overexpression and microvessel density predict survival in the urinary bladder carcinoma. (16868689)
2006
25
Bladder carcinoma and HIV infection during the highly active antiretroviral therapy era: A rare, but intriguing association. Two case reports and literature review. (16798716)
2006
26
Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: relationship with clinical course at 10 years follow-up. (15944797)
2005
27
Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-GuAcrin treatment. (16037714)
2005
28
P16 immunoreactivity is an independent predictor of tumor progression in minimally invasive urothelial bladder carcinoma. (15774242)
2005
29
Staging bladder carcinoma by three-dimensional ultrasound rendering. (15749550)
2005
30
Papillary urothelial bladder carcinoma associated with osteoclast-like giant cells. (16132761)
2005
31
Bladder carcinoma in situ in 2003: state of the art. (14733997)
2004
32
The expression and significance of survivin mRNA in urinary bladder carcinomas. (15138808)
2004
33
Detection of telomerase status by semiquantitative and in situ assays, and by real-time reverse transcription-polymerase chain reaction (telomerase reverse transcriptase) assay in bladder carcinomas. (12656916)
2003
34
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. (14532840)
2003
35
The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. (12239635)
2002
36
PSCA expression is regulated by phorbol ester and cell adhesion in the bladder carcinoma cell line RT112. (11368875)
2001
37
Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. (11559536)
2001
38
Expression of pS2 protein and its relation with the Ki-67 proliferative indices and tumor recurrence in superficial bladder carcinomas. (11528193)
2001
39
Chemosensitization of bladder carcinoma cells by bcl-xL antisense oligonucleotides. (11458048)
2001
40
Noninvasive diagnosis of bladder carcinoma by enzyme-linked immunosorbent assay detection of CD44 isoforms in exfoliated urothelia. (10873090)
2000
41
Epidermal growth factor receptor (EGFR) in the prognosis of bladder carcinoma. Experience of 5 years]. (10900762)
2000
42
Expression of cytokeratin 20 in urinary cytology of patients with bladder carcinoma. (9731913)
1998
43
Expression of three cell adhesion molecules in bladder carcinomas: correlation with pathological features. (9223755)
1997
44
Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas. (9192977)
1997
45
Expression of human chorionic gonadotropin beta subunit genes in superficial and invasive bladder carcinomas. (7543817)
1995
46
Expression and secretion of the beta subunit of human chorionic gonadotropin by bladder carcinoma in vivo and in vitro. (7882356)
1995
47
HPV and p53 in urinary bladder carcinoma. (7808793)
1994
48
neu is not involved in N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder carcinoma or 2-amino-4-(5-nitro-2-furyl)thiazole transformation of rat bladder epithelial cells. (7915641)
1994
49
Eosinophilic cystitis simulating invasive bladder carcinoma. (8351485)
1993
50
Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma. (1759330)
1991

Variations for Bladder Carcinoma

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Clinvar genetic disease variations for Bladder Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.35G> T (p.Gly12Val)single nucleotide variantPathogenicrs104894230GRCh37Chr 11, 534288: 534288
2FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568

Expression for genes affiliated with Bladder Carcinoma

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Expression patterns in normal tissues for genes affiliated with Bladder Carcinoma

Search GEO for disease gene expression data for Bladder Carcinoma.

Pathways for genes affiliated with Bladder Carcinoma

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Pathways related to Bladder Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7FGFR3, HRAS, MIR133A1, SERPINB5

Compounds for genes affiliated with Bladder Carcinoma

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Compounds related to Bladder Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1scca14410.1SERPINB2, SERPINB5
2hpaii4410.0MUC2, H19
3cytosine44 2410.9SERPINB5, SERPINB2, H19
4methionine449.9SLC7A5, HRAS, SERPINB2, NUDT6
5ribonucleic acid449.7NUDT6, SERPINB2, H19, KRT20
6agar449.6NUDT6, JUP, H19, TDGF1P3, HRAS
75-aza-2deoxycytidine449.6SERPINB5, JUP, MUC2, H19, BAGE
8steroid449.6NUDT6, SERPINB5, SERPINB2, H19, HRAS
9nitric oxide44 24 1111.5HRAS, ANG, SERPINB2, SERPINB5, NUDT6
10cysteine449.4NUDT6, MUC2, HRAS, SLC7A5, CGB7, FGFR3
11estrogen449.3SERPINB5, SERPINB2, JUP, MUC2, KRT20, HRAS
12cisplatin44 50 61 1112.2CGB7, HRAS, JUP, SERPINB5
13progesterone44 28 61 24 1113.2SERPINB5, SERPINB2, MUC2, KRT20, HRAS, CGB7
14serine449.2NUDT6, SERPINB5, SERPINB2, JUP, MUC2, HRAS
15calcium44 50 24 1112.1SERPINB2, JUP, MUC2, HRAS, SLC7A5, FGFR3
16paraffin449.0FGFR3, SERPINB5, SERPINB2, JUP, MUC2, H19
17retinoic acid44 249.9NUDT6, SERPINB2, JUP, MUC2, H19, TDGF1P3
18tyrosine448.8NUDT6, SERPINB2, JUP, ANG, H19, KRT20
19vegf448.8NUDT6, SERPINB5, SERPINB2, JUP, ANG, KRT20

GO Terms for genes affiliated with Bladder Carcinoma

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Biological processes related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1morphogenesis of an epitheliumGO:00200910.1FGFR3, SERPINB5

Products for genes affiliated with Bladder Carcinoma

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Sources for Bladder Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet