MCID: BLD042
MIFTS: 70

Bladder Carcinoma malady

Cancer, Nephrological categories

Summaries for Bladder Carcinoma

Sources:
8Disease Ontology, 34MedlinePlus, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Bladder Carcinoma, also known as bladder cancer, is related to bladder transitional cell carcinoma and transitional cell carcinoma. An important gene associated with Bladder Carcinoma is SLC7A5 (solute carrier family 7 (amino acid transporter light chain, L system), member 5), and among its related pathways is PAK Pathway. The drugs bcg vaccine and cisplatin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:8 A urinary bladder cancer that arises from tissues of the bladder.

Genetics Home Reference:21 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).

Wikipedia:64 Bladder cancer is any of several types of malignancy arising from the epithelial lining (i.e., the... more...

Description from OMIM:47 109800

Aliases & Classifications for Bladder Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Aliases & Descriptions:

bladder carcinoma 8 45 31
bladder cancer 8 64 21 45 34
urinary bladder cancer 8 64 21 10
malignant tumor of urinary bladder 64 22 21
cancer of the bladder 64 21
carcinoma of bladder 8 61
carcinoma of urinary bladder 8
tumor of the bladder 8
carcinoma bladder 8
bladder neoplasm 61
bladder tumors 45


Related Diseases for Bladder Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bladder Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma30.9MKI67, CDH1, KRT20
2transitional cell carcinoma30.9UPK2
3bladder carcinoma in situ30.8UPK2
4adenocarcinoma30.3JUP, H19, PSCA, UPK3A, AREG, CGB7
5papillary carcinoma30.2MKI67, MUC2, CDH1, KRT20, SERPINB5
6colorectal cancer30.1SERPINB5, JUP, H19, AREG, ANG, MUC2
7adenoma30.1MKI67, CGB7, AREG, H19, JUP, MUC2
8squamous cell carcinoma29.9BAGE, MKI67, MUC2, CDH1, FGFR3, SLC7A5
9oral cancer29.9CDH1, SLC7A5, TERC
10stomach cancer29.9CDH1
11bladder cancer susceptibility10.6
12bladder disease10.4
13verrucous carcinoma10.4
14hydronephrosis10.4
15amyloid tumor10.4
16inflammatory myofibroblastic tumor10.4
17urinary bladder small cell neuroendocrine carcinoma10.3
18diphtheria10.3
19bladder cancer, somatic10.3
20small cell carcinoma10.3
21bacteriuria10.2
22bladder tuberculosis10.2
23tuberculosis10.2
24bone carcinoma10.2
25hepatitis c10.2
26leukemoid reaction10.2
27granulomatous hepatitis10.2
28hepatitis b10.2
29perivascular epithelioid cell tumor10.2
30granular cell tumor10.2
31urachal cancer10.2
32orchitis10.2
33bladder adenocarcinoma10.2
34hypoxia10.2
35parathyroid carcinoma10.2
36inverted transitional papilloma10.2
37colon squamous cell carcinoma10.2
38prostate transitional cell carcinoma10.2
39pernicious anemia10.2
40urinary bladder inverted papilloma10.2
41bladder transitional cell papilloma10.2
42spinal cancer10.2
43transitional papilloma10.2
44acute febrile neutrophilic dermatosis10.2
45young syndrome10.2
46spinal cord injury10.2
47hinman's syndrome10.2
48anaplastic large cell lymphoma10.1
49malakoplakia10.1
50polymyositis10.1

Graphical network of the top 20 diseases related to Bladder Carcinoma:



Diseases related to bladder carcinoma

Clinical Features for Bladder Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

109800

Drugs & Therapeutics for Bladder Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bladder Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bladder Carcinoma

Search NIH Clinical Center for Bladder Carcinoma

Search CenterWatch for Bladder Carcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Carcinoma:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Carcinoma:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Carcinoma

Sources:
22GTR
See all sources

Genetic tests related to Bladder Carcinoma:

id Genetic test Affiliating Genes
1 Malignant Tumor Of Urinary Bladder22

Anatomical Context for Bladder Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Bladder Carcinoma:

33
Whole blood, Lymph node, Brain, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Lung, Thyroid, Adrenal gland, Breast, Ovary, Prostate, Testis, Cervix, Monocytes, Dentritic cells, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Bronchial epithelium, Pituitary

Animal Models for Bladder Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Bladder Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.0H19, AREG, MUC2, CDH1, FGFR3, TERC
2MP:000200610.7H19, PSCA, MUC2, CDH1, FGFR3, TERC

Publications for Bladder Carcinoma

Sources:
51PubMed
See all sources

Articles related to Bladder Carcinoma:

(show top 50)    (show all 1839)
idTitleAuthorsYear
1
Apoptosis of bladder transitional cell carcinoma T24 cells induced by adenovirus-mediated inducible nitric oxide synthase gene transfection. (24255584)
2013
2
Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 Human Bladder Carcinoma Cells through the Inhibitions of Matrix Metalloproteinase-2/-9 Signaling. (23431332)
2013
3
Pure primary small cell carcinoma of urinary bladder: A rare diagnostic entity. (24049389)
2013
4
Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma. (24324362)
2013
5
Bladder carcinoma in situ (CIS) in Australia: a rising incidence for an under-reported malignancy. (23573811)
2013
6
Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response. (22720207)
2012
7
Urothelial bladder carcinoma in young patients is characterized by a relatively good prognosis. (22283443)
2012
8
Enhanced computed tomograms provide accurate assessment of local extension and stage of bladder carcinoma. (22397775)
2012
9
Prognostic significance of P27 (Kip 1) and MUC1 in papillary transitional cell carcinoma of the urinary bladder. (21346826)
2011
10
Palmar fasciitis and polyarthritis syndrome associated with transitional cell carcinoma of the bladder. (20638154)
2011
11
Survival of patients with transitional cell carcinoma of the urinary bladder in indonesia: a single institution review. (21545228)
2011
12
Serum Th1 and Th2 cytokine balance in patients of superficial transitional cell carcinoma of bladder pre- and post-intravesical combination immunotherapy. (20105083)
2010
13
Evaluation of relationship between HIF-1alpha immunoreactivity and stage, grade, angiogenic profile and proliferative index in bladder urothelial carcinomas. (19484376)
2010
14
Expression of fibroblast growth factor receptor 3 in the recurrence of non-muscle-invasive urothelial carcinoma of the bladder. (20414420)
2010
15
High-grade hyperinvasive sarcomatoid urothelial bladder carcinoma demonstrating complete response to bladder-preserving chemoradiation. (19526087)
2009
16
Supraphysiological thermal injury in different human bladder carcinoma cell lines. (19657740)
2009
17
Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1). (19019843)
2009
18
HER2 overexpression and amplification in urothelial carcinoma of the bladder is associated with MYC coamplification in a subset of cases. (18628098)
2008
19
E-cadherin tissue expression and urinary soluble forms of E-cadherin in patients with bladder transitional cell carcinoma. (18931551)
2008
20
Beta-hCG producing urothelial carcinoma of the urinary bladder: a case report]. (18516923)
2008
21
High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. (17786288)
2007
22
Survival and progression in high grade tumour subset of G2 and G3 pT1 bladder transitional cell carcinoma. (16784833)
2006
23
Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. (16532037)
2006
24
Efficacy of adjuvant 5-flurouracil and leucovorin in metastatic gall bladder carcinoma. (17090856)
2006
25
Analysis of HER2 expression in primary urinary bladder carcinoma and corresponding metastases. (16042748)
2005
26
Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder. (15679809)
2005
27
Correlation between clinical and pathological staging in a series of radical cystectomies for bladder carcinoma. (15794783)
2005
28
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. (15885659)
2005
29
HER-2/neu protein overexpression and gene amplification in human transitional cell carcinoma of the bladder. (15072912)
2004
30
Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. (15140401)
2004
31
Evaluation of chromosome 8 and 11 aneuploidies in washings and biopsy materials of bladder transitional cell carcinoma. (12660029)
2003
32
Molecular urinary sediment analysis in patients with transitional cell bladder carcinoma. (14981972)
2003
33
Qualitative and quantitative detection of urinary human complement factor H-related protein (BTA stat and BTA TRAK) and fragments of cytokeratins 8, 18 (UBC rapid and UBC IRMA) as markers for transitional cell carcinoma of the bladder. (11999463)
2002
34
Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. (11297248)
2001
35
Frequent p16/MTS1 inactivation in early stages of urothelial carcinoma of the bladder is not associated with tumor recurrence. (11752859)
2001
36
Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder. (11555602)
2001
37
Carcinoma of the urinary bladder resembling lymphoepithelioma]. (11291269)
2000
38
PCNA immunostaining as a valid alternative to tritiated thymidine-autoradiography to detect proliferative cell fraction in transitional cell bladder carcinomas. (10904880)
2000
39
Gastric outlet obstruction in carcinoma gall bladder. (10407561)
1999
40
The expression of PAX5 in human transitional cell carcinoma of the bladder: relationship with de-differentiation. (10368252)
1999
41
Somatic mutation of PTEN in bladder carcinoma. (10360673)
1999
42
Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder. (9817940)
1998
43
A hot spot for p53 mutation in transitional cell carcinoma of the bladder: clues to the etiology of bladder cancer. (9264274)
1997
44
Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. (9018118)
1997
45
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas. (7776437)
1995
46
Expression of c-erbB-2 protein, neuron-specific enolase and DNA flow cytometry in locally advanced transitional cell carcinoma of the urinary bladder. (8099896)
1993
47
c-erbB-2 (HER-2/neu) oncopeptide immunoreactivity in localized, high-grade transitional cell carcinoma of the bladder. (1364264)
1992
48
Human chorionic gonadotropin, neuron specific enolase and deoxyribonucleic acid flow cytometry in patients with high grade bladder carcinoma. (2313795)
1990
49
Primary linitis plastica carcinoma of urinary bladder. (6312662)
1983
50
Primary carcinoma in bladder diverticulum. (18121514)
1948

Genetic Variations for Bladder Carcinoma

Expression for genes affiliated with Bladder Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bladder Carcinoma

Search GEO for disease gene expression data for Bladder Carcinoma.

Pathways for genes affiliated with Bladder Carcinoma

Sources:
52QIAGEN
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Pathways related to Bladder Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9FGFR3, CDH1, NUDT6, AREG, JUP

Compounds for genes affiliated with Bladder Carcinoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Bladder Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1vegf4511.7AREG, ANG, MKI67, NUDT6, CDH1, FGFR3
2retinoic acid45 2412.7MKI67, MUC2, NUDT6, CDH1, TERC, AREG
3tyrosine4511.7ANG, SLC7A5, FGFR3, CDH1, JUP, AREG
4paraffin4511.7MKI67, FGFR3, JUP, H19, MUC2, CDH1
5serine4511.6JUP, CDH1, FGFR3, SLC7A5, SERPINB5, NUDT6
6progesterone45 60 29 11 2415.5MKI67, MUC2, CDH1, KRT20, TERC, SERPINB5
7cisplatin45 50 60 1114.4MKI67, CDH1, TERC, SERPINB5, JUP, CGB7
8testosterone45 60 11 2414.4SERPINB5, KRT20, CDH1, NUDT6, MKI67, CGB7
95-aza-2deoxycytidine4511.4H19, JUP, SERPINB5, BAGE, MUC2, CDH1
10agar4511.4TDGF1P3, TERC, CDH1, H19, JUP, NUDT6
11cysteine4511.2NUDT6, CGB7, SLC7A5, MUC2, FGFR3, CDH1
12doxorubicin45 50 1113.2MKI67, KRT20, TERC, FGFR3, CDH1
13thymidine45 2412.2TERC, AREG, NUDT6, MKI67, H19
14hematoxylin4511.2KRT20, MUC2, MKI67, CDH1
15p0024511.1SERPINB5, CDH1, MKI67, JUP
16methotrexate45 50 1113.1CDH1, MUC2, MKI67, CGB7
17calcium45 50 11 2414.1NUDT6, SLC7A5, FGFR3, CDH1, MUC2, JUP
185fluorouracil4511.1MUC2, CDH1, TERC, MKI67
19tamoxifen45 50 29 1114.1MKI67, CDH1, TERC, SERPINB5
20oligonucleotide4511.0AREG, MUC2, FGFR3, TERC, JUP
21pd 98,0594511.0MUC2, NUDT6, CDH1, AREG
22cytosine45 2411.9H19, SERPINB5, CDH1
23steroid4510.9MKI67, H19, SERPINB5, NUDT6
24alpha e4510.9JUP, CDH1
25azathioprine45 50 2 1113.9CDH1, MUC2, H19
26dexamethasone45 50 29 1113.8JUP, CDH1, AREG, MUC2
27hpaii4510.7MUC2, H19
28chi 24510.4MKI67, CDH1

GO Terms for genes affiliated with Bladder Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:01634210.7CDH1, JUP
2internal side of plasma membraneGO:00989810.4FGFR3, CDH1, JUP

Biological processes related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cochlea developmentGO:09010210.7FGFR3, CDH1
2cellular response to indole-3-methanolGO:07168110.6CDH1, JUP
3morphogenesis of an epitheliumGO:00200910.4SERPINB5, FGFR3

Products for genes affiliated with Bladder Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet