MCID: BLD042
MIFTS: 73

Bladder Carcinoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Bladder Carcinoma

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8Disease Ontology, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Bladder Carcinoma, also known as bladder cancer, is related to bladder carcinoma in situ and bladder transitional cell carcinoma. An important gene associated with Bladder Carcinoma is SLC7A5 (solute carrier family 7 (amino acid transporter light chain, L system), member 5), and among its related pathways is PAK Pathway. The drugs bcg vaccine and cisplatin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, endothelial and lymph node, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:8 A urinary bladder cancer that arises from tissues of the bladder.

Genetics Home Reference:21 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).

Wikipedia:63 Bladder cancer is any of several types of malignancy arising from the epithelial lining (i.e., the... more...

Description from OMIM:46 109800

Aliases & Classifications for Bladder Carcinoma

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Sources:
8Disease Ontology, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 63Wikipedia, 21Genetics Home Reference, 10DISEASES, 33MedlinePlus, 22GTR, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

bladder carcinoma 8 44 30
bladder cancer 8 63 21 44 33
urinary bladder cancer 8 63 21 10
malignant tumor of urinary bladder 63 22 21
cancer of the bladder 63 21
carcinoma of bladder 8 60
carcinoma of urinary bladder 8
tumor of the bladder 8
carcinoma bladder 8
bladder neoplasm 60
bladder tumors 44


Related Diseases for Bladder Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Bladder Carcinoma family:

Bladder Carcinoma in Situ Bladder Benign Neoplasm

Diseases related to Bladder Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma in situ31.0UPK2
2bladder transitional cell carcinoma30.9MKI67, CDH1, KRT20
3transitional cell carcinoma30.9UPK2
4retinoblastoma30.4TERC, FGFR3, MKI67
5lung cancer30.3H19, BAGE, KRT20, TERC
6cystitis30.3UPK2
7leukemia30.3H19, AREG, NUDT6, FGFR3, TERC
8gallbladder cancer30.3MUC2
9adenocarcinoma30.2JUP, H19, PSCA, UPK3A, AREG, CGB7
10papillary carcinoma30.2MKI67, MUC2, CDH1, KRT20, SERPINB5
11ovarian cancer30.2JUP, AREG, MUC2, CDH1, KRT20, TERC
12inverted papilloma30.2MKI67, KRT20
13breast cancer30.1JUP, H19, AREG, CGB7, MKI67, MUC2
14kidney cancer30.1JUP, MKI67, CDH1, KRT20
15adenoma30.1MKI67, CGB7, AREG, H19, JUP, MUC2
16colorectal cancer30.1SERPINB5, JUP, H19, AREG, ANG, MUC2
17colon cancer30.1JUP, AREG, MUC2, CDH1, KRT20, TDGF1P3
18sarcoma30.1JUP, MKI67, SERPINB5
19pancreatic cancer30.0SERPINB5, MUC2, PSCA
20squamous cell carcinoma29.9BAGE, MKI67, MUC2, CDH1, FGFR3, SLC7A5
21melanoma29.9JUP, AREG, ANG, BAGE, MKI67, NUDT6
22prostate cancer29.8JUP, PSCA, MKI67, CDH1, TERC, SERPINB5
23papilloma29.8AREG, FGFR3, KRT20
24myeloma29.8AREG, ANG, FGFR3
25leiomyoma29.8MKI67
26cervical cancer29.8JUP, H19, AREG, CGB7, FGFR3, TERC
27stomach cancer29.8CDH1
28in situ carcinoma10.7
29cell type cancer10.4
30bladder disease10.4
31verrucous carcinoma10.4
32hydronephrosis10.3
33lymph node cancer10.3
34amyloid tumor10.3
35prostatitis10.3
36urinary bladder small cell neuroendocrine carcinoma10.3
37small cell carcinoma10.3
38hepatitis10.3
39diphtheria10.2
40bone carcinoma10.2
41leukemoid reaction10.2
42granulomatous hepatitis10.2
43renal cell carcinoma10.2
44bacteriuria10.2
45bladder tuberculosis10.2
46tuberculosis10.2
47perivascular epithelioid cell tumor10.2
48granular cell tumor10.2
49perivascular tumor10.2
50orchitis10.1

Graphical network of the top 20 diseases related to Bladder Carcinoma:



Diseases related to bladder carcinoma

Clinical Features for Bladder Carcinoma

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46OMIM
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Clinical features from OMIM:

109800

Drugs & Therapeutics for Bladder Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bladder Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bladder Carcinoma

Search NIH Clinical Center for Bladder Carcinoma

Search CenterWatch for Bladder Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Carcinoma:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Carcinoma:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Carcinoma

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22GTR
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Genetic tests related to Bladder Carcinoma:

id Genetic test Affiliating Genes
1 Malignant Tumor of Urinary Bladder22

Anatomical Context for Bladder Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Bladder Carcinoma:

32
Prostate, Endothelial, Lymph node, Testes, Lung, Kidney, Breast, Brain, Bone, Thyroid, Ovary, Colon, Cervix, Testis, T cells, Pituitary, Spinal cord, Monocytes, B lymphoblasts, Nk cells, Dentritic cells, Heart, Smooth muscle, Skeletal muscle, Adrenal gland, Adipocyte

Animal Models for Bladder Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bladder Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.0AREG, MUC2, CDH1, FGFR3, TERC, H19
2MP:000200610.7TERC, FGFR3, CDH1, MUC2, PSCA, H19

Publications for Bladder Carcinoma

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50PubMed
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Articles related to Bladder Carcinoma:

(show top 50)    (show all 1834)
idTitleAuthorsYear
1
The diagnostic accuracy of multidetector computed tomography with multiplanar reformatted imaging and virtual cystoscopy in the early detection and evaluation of bladder carcinoma: comparison with conventional cystoscopy. (22623028)
2013
2
Metastatic squamous cell carcinoma urinary bladder coexisting with tuberculosis in pelvic lymph nodes. (24296773)
2013
3
Squamous cell carcinoma of the bladder mimicking interstitial cystitis and voiding dysfunction. (24224109)
2013
4
Immunohistochemical analysis of the role and relationship between Notch-1 and Oct-4 expression in urinary bladder carcinoma. (23594289)
2013
5
Advanced Neuroimaging Studies in a Patient with Brain Metastases from Transitional Cell Carcinoma of the Bladder. (23551927)
2013
6
Comparing intra-arterial chemotherapy combined with intravesical chemotherapy versus intravesical chemotherapy alone: a randomised prospective pilot study for T1G3 bladder transitional cell carcinoma after bladder-preserving surgery. (23511989)
2013
7
Lymphoepithelioma-like carcinoma of the bladder: a case report and review of the literature. (23710410)
2013
8
Radical cystectomy and orthotopic urinary diversion in male patients with pT4a urothelial bladder carcinoma: oncological outcomes. (23521752)
2013
9
Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma. (21956756)
2012
10
Meta-analysis of studies analyzing the role of human papillomavirus in the development of bladder carcinoma. (22536466)
2012
11
Small cell carcinoma of the urinary bladder with hypercalcemia. (21499925)
2012
12
Urine and serum cathepsin B concentrations in the transitional cell carcinoma of the bladder. (22467319)
2012
13
Bladder Carcinoma after ABVD Chemotherapy for Hodgkin's Lymphoma: A Case Report. (22666204)
2012
14
Sex-specific hormone receptors in urothelial carcinomas of the human urinary bladder: a comparative analysis of clinicopathological features and survival outcomes according to receptor expression. (19372057)
2011
15
Fatty acid binding proteins (FABPs) in prostate, bladder and kidney cancer cell lines and the use of IL-FABP as survival predictor in patients with renal cell carcinoma. (21767383)
2011
16
Molecular markers and bladder carcinoma: Schistosomal and non-schistosomal. (20934419)
2011
17
Vascular endothelial growth factor-C associated with computed tomography used in the diagnosis of lymph node metastasis of bladder carcinoma. (22078583)
2011
18
Co-administration of intravesical bacillus Calmette-GuAcrin and interferon I+-2B as first line in treating superficial transitional cell carcinoma of the urinary bladder. (21332904)
2011
19
Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma. (21273058)
2011
20
Can Bcl-XL expression predict the radio sensitivity of bilharzial-related squamous bladder carcinoma? A prospective comparative study. (21226954)
2011
21
Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. (20582552)
2010
22
Initial results of bladder preserving approach by chemo-radiotherapy in patients with muscle invading transitional cell carcinoma. (21057568)
2009
23
High-grade transitional cell carcinoma and melanosis of urinary bladder: case report and review of the literature. (19056107)
2009
24
Activation of extracellular regulated kinases (ERK1/2) predicts poor prognosis in urothelial bladder carcinoma and is not associated with B-Raf gene mutations. (19404844)
2009
25
Transitional cell carcinoma of the urinary bladder: a clinicopathological study. (18946612)
2008
26
An analysis of the effect of statin use on the efficacy of bacillus calmette-guerin treatment for transitional cell carcinoma of the bladder. (18707737)
2008
27
Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy. (17483026)
2007
28
Long-term intravesical adjuvant chemotherapy further reduces recurrence rate compared with short-term intravesical chemotherapy and short-term therapy with Bacillus Calmette-GuAcrin (BCG) in patients with non-muscle-invasive bladder carcinoma. (17383080)
2007
29
Two-dimensional agnor evaluation as a prognostic variable in urinary bladder carcinoma: a different approach via total agnor area/nucleus area per cell. (17011198)
2007
30
Genetic alterations in urothelial bladder carcinoma: an updated review. (16470587)
2006
31
Heat shock protein 70 expression in relation to apoptosis in primary bladder transitional cell carcinoma. (16438908)
2005
32
Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. (16084939)
2005
33
Tissue-specific adherent Enterococcus faecalis strains that show highly efficient adhesion to human bladder carcinoma T24 cells also adhere to extracellular matrix proteins. (15385489)
2004
34
HER-2 and TOP 2A gene amplifications in urinary bladder carcinoma]. (12647367)
2002
35
HER-2--a possible target for therapy of metastatic urinary bladder carcinoma. (12195748)
2002
36
Clinical significance of p53, MDM2 and bcl-2 expression in transitional cell carcinoma of the bladder. (11836589)
2002
37
Epidermal growth factor receptor (EGFR) in the prognosis of bladder carcinoma. Experience of 5 years]. (10900762)
2000
38
Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. (9915473)
1999
39
Reciprocal expression of bcl-2 and p53 oncoproteins in urothelial dysplasia and carcinoma of the urinary bladder. (9759996)
1998
40
Immunohistochemical analysis of nm23 protein in transitional cell carcinoma of the bladder. (8813946)
1996
41
Loss of p16 gene in bladder cancer and genitourinary carcinoma cell lines]. (9590746)
1996
42
Fibroblast growth factors and their specific binding sites in normal urothelium and transitional cell carcinoma (TCC) of the human bladder. (7549793)
1995
43
Sarcomatoid carcinoma of the bladder in a 25-year-old man]. (8570563)
1995
44
Immunohistochemical analysis of nm23 protein in transitional cell carcinoma of the bladder. (8535713)
1995
45
Treatment of bladder carcinoma in situ with mitomycin C: long-term follow-up. (8002217)
1994
46
Verrucous carcinoma of the bilharzial bladder. Impact of invasiveness on survival. (8351470)
1993
47
Blood tests and prognosis in bladder carcinomas treated with definitive radiotherapy. (8356221)
1993
48
Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma. (1302559)
1992
49
Nephrogenic adenoma in patients with transitional cell carcinoma of the bladder receiving intravesical thiotepa. (3121867)
1988
50
Condylomata acuminata and verrucous carcinoma of the bladder: case report and literature review. (3511293)
1986

Genetic Variations for Bladder Carcinoma

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Expression for genes affiliated with Bladder Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Carcinoma

Search GEO for disease gene expression data for Bladder Carcinoma.

Pathways for genes affiliated with Bladder Carcinoma

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51QIAGEN
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Pathways related to Bladder Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.9FGFR3, CDH1, NUDT6, AREG, JUP

Compounds for genes affiliated with Bladder Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Bladder Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1vegf4411.7JUP, AREG, ANG, MKI67, NUDT6, CDH1
2retinoic acid44 2412.7CGB7, AREG, H19, JUP, MKI67, MUC2
3tyrosine4411.7JUP, H19, AREG, ANG, MKI67, NUDT6
4paraffin4411.7SERPINB5, JUP, H19, MKI67, MUC2, CDH1
5serine4411.6JUP, AREG, MKI67, MUC2, NUDT6, CDH1
6progesterone44 59 28 11 2415.5AREG, CGB7, MKI67, MUC2, CDH1, KRT20
7cisplatin44 49 59 1114.4JUP, AREG, CGB7, MKI67, CDH1, TERC
8testosterone44 59 11 2414.4AREG, CGB7, MKI67, NUDT6, CDH1, KRT20
95-aza-2deoxycytidine4411.4JUP, H19, BAGE, MUC2, CDH1, SERPINB5
10agar4411.4JUP, H19, NUDT6, CDH1, TERC, TDGF1P3
11cysteine4411.2CGB7, MUC2, NUDT6, CDH1, FGFR3, SLC7A5
12doxorubicin44 49 1113.2MKI67, CDH1, FGFR3, KRT20, TERC
13thymidine44 2412.2TERC, NUDT6, MKI67, AREG, H19
14hematoxylin4411.2MKI67, MUC2, CDH1, KRT20
15p0024411.1JUP, MKI67, CDH1, SERPINB5
16methotrexate44 49 1113.1CGB7, MKI67, MUC2, CDH1
17calcium44 49 11 2414.1JUP, AREG, MKI67, MUC2, NUDT6, CDH1
185fluorouracil4411.1MKI67, MUC2, CDH1, TERC
19tamoxifen44 49 28 1114.1SERPINB5, TERC, CDH1, MKI67
20oligonucleotide4411.0JUP, AREG, MUC2, FGFR3, TERC
21pd 98,0594411.0AREG, MUC2, NUDT6, CDH1
22cytosine44 2411.9H19, CDH1, SERPINB5
23steroid4410.9SERPINB5, NUDT6, MKI67, H19
24alpha e4410.9CDH1, JUP
25azathioprine44 49 2 1113.9CDH1, MUC2, H19
26dexamethasone44 49 28 1113.8CDH1, MUC2, AREG, JUP
27hpaii4410.7MUC2, H19
28chi 24410.4MKI67, CDH1

GO Terms for genes affiliated with Bladder Carcinoma

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16Gene Ontology
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Cellular components related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:01634210.7CDH1, JUP
2internal side of plasma membraneGO:00989810.4FGFR3, CDH1, JUP

Biological processes related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cochlea developmentGO:09010210.7FGFR3, CDH1
2cellular response to indole-3-methanolGO:07168110.6CDH1, JUP
3morphogenesis of an epitheliumGO:00200910.4SERPINB5, FGFR3

Products for genes affiliated with Bladder Carcinoma

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Sources for Bladder Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet