MCID: BLD042
MIFTS: 73

Bladder Carcinoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Bladder Carcinoma

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8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The bladder is a hollow organ in your lower abdomen that stores urine. bladder cancer occurs in the lining of the bladder. it is the sixth most common type of cancer in the united states. symptoms include blood in your urine a frequent urge to urinate pain when you urinate low back pain risk factors for developing bladder cancer include smoking and exposure to certain chemicals in the workplace. people with a family history of bladder cancer or who are older, white, or male have a higher risk. treatments for bladder cancer include surgery, radiation therapy, chemotherapy, and biologic therapy. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Bladder Carcinoma, also known as bladder cancer, is related to bladder carcinoma in situ and bladder transitional cell carcinoma. An important gene associated with Bladder Carcinoma is SLC7A5 (solute carrier family 7 (amino acid transporter light chain, L system), member 5), and among its related pathways is PAK Pathway. The drugs bcg vaccine and cisplatin and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, endothelial and lymph node, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:8 A urinary bladder cancer that arises from tissues of the bladder.

Genetics Home Reference:21 Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC).

Wikipedia:63 Bladder cancer is any of several types of malignancy arising from the epithelial lining (i.e., the... more...

Description from OMIM:46 109800

Aliases & Classifications for Bladder Carcinoma

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8Disease Ontology, 63Wikipedia, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

bladder carcinoma 8 44 30
bladder cancer 8 63 21 44 33
urinary bladder cancer 8 63 21 10
malignant tumor of urinary bladder 63 22 21
cancer of the bladder 63 21
carcinoma of bladder 8 60
carcinoma of urinary bladder 8
tumor of the bladder 8
carcinoma bladder 8
bladder neoplasm 60
bladder tumors 44


Related Diseases for Bladder Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Bladder Carcinoma family:

Bladder Carcinoma in Situ Bladder Benign Neoplasm

Diseases related to Bladder Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma in situ31.0UPK2
2bladder transitional cell carcinoma30.9MKI67, CDH1, KRT20
3transitional cell carcinoma30.9UPK2
4retinoblastoma30.4TERC, FGFR3, MKI67
5lung cancer30.3H19, BAGE, KRT20, TERC
6cystitis30.3UPK2
7leukemia30.3H19, AREG, NUDT6, FGFR3, TERC
8gallbladder cancer30.3MUC2
9adenocarcinoma30.2JUP, H19, PSCA, UPK3A, AREG, CGB7
10papillary carcinoma30.2MKI67, MUC2, CDH1, KRT20, SERPINB5
11ovarian cancer30.2JUP, AREG, MUC2, CDH1, KRT20, TERC
12inverted papilloma30.2MKI67, KRT20
13breast cancer30.1JUP, H19, AREG, CGB7, MKI67, MUC2
14kidney cancer30.1JUP, MKI67, CDH1, KRT20
15adenoma30.1MKI67, CGB7, AREG, H19, JUP, MUC2
16colorectal cancer30.1SERPINB5, JUP, H19, AREG, ANG, MUC2
17colon cancer30.1JUP, AREG, MUC2, CDH1, KRT20, TDGF1P3
18sarcoma30.1JUP, MKI67, SERPINB5
19pancreatic cancer30.0SERPINB5, MUC2, PSCA
20squamous cell carcinoma29.9BAGE, MKI67, MUC2, CDH1, FGFR3, SLC7A5
21melanoma29.9JUP, AREG, ANG, BAGE, MKI67, NUDT6
22prostate cancer29.8JUP, PSCA, MKI67, CDH1, TERC, SERPINB5
23papilloma29.8AREG, FGFR3, KRT20
24myeloma29.8AREG, ANG, FGFR3
25leiomyoma29.8MKI67
26cervical cancer29.8JUP, H19, AREG, CGB7, FGFR3, TERC
27stomach cancer29.8CDH1
28in situ carcinoma10.7
29cell type cancer10.4
30bladder disease10.4
31verrucous carcinoma10.4
32hydronephrosis10.3
33lymph node cancer10.3
34amyloid tumor10.3
35prostatitis10.3
36urinary bladder small cell neuroendocrine carcinoma10.3
37small cell carcinoma10.3
38hepatitis10.3
39diphtheria10.2
40bone carcinoma10.2
41leukemoid reaction10.2
42granulomatous hepatitis10.2
43renal cell carcinoma10.2
44bacteriuria10.2
45bladder tuberculosis10.2
46tuberculosis10.2
47perivascular epithelioid cell tumor10.2
48granular cell tumor10.2
49perivascular tumor10.2
50orchitis10.1

Graphical network of the top 20 diseases related to Bladder Carcinoma:



Diseases related to bladder carcinoma

Clinical Features for Bladder Carcinoma

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46OMIM
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Clinical features from OMIM:

109800

Drugs & Therapeutics for Bladder Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bladder Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bladder Carcinoma

Search NIH Clinical Center for Bladder Carcinoma

Search CenterWatch for Bladder Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Carcinoma:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Carcinoma:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Carcinoma

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22GTR
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Genetic tests related to Bladder Carcinoma:

id Genetic test Affiliating Genes
1 Malignant Tumor of Urinary Bladder22

Anatomical Context for Bladder Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Bladder Carcinoma:

32
Prostate, Endothelial, Lymph node, Testes, Lung, Kidney, Brain, Breast, Bone, Thyroid, Cervix, Colon, Ovary, Pituitary, T cells, Monocytes, Testis, Spinal cord, B lymphoblasts, Nk cells, Heart, Adrenal gland, Skeletal muscle, Smooth muscle, Adipocyte, Dentritic cells

Animal Models for Bladder Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bladder Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.0AREG, MUC2, CDH1, FGFR3, TERC, H19
2MP:000200610.7TERC, FGFR3, CDH1, MUC2, PSCA, H19

Publications for Bladder Carcinoma

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50PubMed
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Articles related to Bladder Carcinoma:

(show top 50)    (show all 1834)
idTitleAuthorsYear
1
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. (24036236)
2014
2
MicroRNA Profile to Predict Gemcitabine Resistance in Bladder Carcinoma Cell Lines. (23946872)
2013
3
Squamous cell carcinoma in exstrophy of the bladder. (23956833)
2013
4
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3. (23407876)
2013
5
Results of long-term follow-up of patients with superficial bladder carcinoma treated with intravesically applied bacillus Calmette-Guerin vaccine according to the schedule of 6 weekly + 6 monthly instillations. (20843705)
2012
6
Metastatic bladder transitional cell carcinoma presenting as a vascularised cutaneous right arm lesion. (21779951)
2012
7
Endobronchial metastasis from transitional cell carcinoma of the urinary bladder. (23169086)
2011
8
P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma. (20473917)
2011
9
External beam radiotherapy of bladder carcinoma: considerations in determining the irradiation field margins. (20941815)
2010
10
AdCD40L immunogene therapy for bladder carcinoma--the first phase I/IIa trial. (20448220)
2010
11
Involvement of T helper type 17 and regulatory T cell activity in tumour immunology of bladder carcinoma. (20646003)
2010
12
Utility of pelvic bone SPET in imaging urinary bladder filling defects in urinary bladder carcinoma. (20411174)
2010
13
Role of polysomy 17 in transitional cell carcinoma of the bladder: immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17. (19443884)
2009
14
The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette-GuAcrin (BCG) immunotherapy for urothelial carcinoma of the bladder. (19967427)
2009
15
Clinical use of serum CA-125 levels in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder. (18555706)
2009
16
Preparation and in-vitro bioactivity of a novel superantigen conjugate targeting bladder carcinoma. (19589228)
2009
17
Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma. (18257856)
2008
18
Re: A randomized trial of radical radiotherapy for the management of pT1G3 NXM0 transitional cell carcinoma of the bladder. S. J. Harland, H. Kynaston, K. Grigor, D. M. Wallace, C. Beacock, R. Kockelbergh, S. Clawson, T. Barlow, M. K. Parmar and G. O. Griffiths; National Cancer Research Institute Bladder Clinical Studies Group. J Urol 2007; 178: 807-813. (18295248)
2008
19
PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. (17340590)
2007
20
Low prevalence of Helicobacteraceae in gall-stone disease and gall-bladder carcinoma in the German population. (17346303)
2007
21
Primary small cell bladder carcinoma. (17679477)
2007
22
Consistency of microstaging pT1 bladder transitional cell carcinoma. (17322343)
2007
23
Extrapulmonary small cell carcinoma of the bladder. (17270661)
2007
24
Proliferating cell nuclear antigen (PCNA) overexpression and microvessel density predict survival in the urinary bladder carcinoma. (16868689)
2006
25
Evaluation of gall bladder carcinoma with dynamic magnetic resonance imaging and magnetic resonance cholangiopancreatography. (16732816)
2006
26
Combined effect of tumor necrosis factor-alpha and ionizing radiation on the induction of apoptosis in 5637 bladder carcinoma cells. (16896593)
2006
27
Novel approach of human epidermal growth factor receptor 2 detection in noninvasive and invasive transitional cell carcinoma of the bladder. (16469569)
2006
28
Multitarget fluorescence in situ hybridization and melanoma antigen genes analysis in primary bladder carcinoma. (16364760)
2006
29
Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases. (16283378)
2006
30
Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity. (15766588)
2005
31
Squamous cell carcinoma of the bladder presenting as vulvitis and cliteromegaly. (15581990)
2004
32
Role of intravenous urography and transabdominal ultrasonography in the diagnosis of bladder carcinoma. (15689243)
2004
33
The apoptotic process of human bladder carcinoma T24 cells induced by retinoid. (15316139)
2004
34
Altered mRNA expression of the Rb and p16 tumor suppressor genes and of CDK4 in transitional cell carcinomas of the urinary bladder associated with tumor progression. (15161057)
2004
35
Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. (15183956)
2004
36
Problems in early diagnosis of bladder cancer in a spinal cord injury patient: report of a case of simultaneous production of granulocyte colony stimulating factor and parathyroid hormone-related protein by squamous cell carcinoma of urinary bladder. (12201902)
2002
37
Genetic aberrations of NAT2 and chromosome 8: their association with progression in transitional cell carcinoma of the urinary bladder. (11598453)
2001
38
Localization of metallothionein in urothelial carcinoma of the human urinary bladder: an immunohistochemical study including correlation with HLA-DR antigen, p53, and proliferation indices. (11497256)
2001
39
Influence of cigarette smoking on P53 gene mutations in bladder carcinomas. (11712801)
2001
40
Relevance of p53 gene alterations for tumor recurrence in patients with superficial transitional cell carcinoma of the bladder. (11223675)
2001
41
The mechanism of p16 gene inactivation in human bladder transitional cell carcinoma]. (11869511)
1999
42
Dermatomyositis with the features of inclusion body myositis associated with carcinoma of the bladder. (10583182)
1999
43
Invasion of the bladder by transitional cell carcinoma: its relation to histologic grade and expression of p53, MIB-1, c-erb B-2, epidermal growth factor receptor, and bcl-2. (9477105)
1998
44
Myxoid and sclerosing sarcomatoid transitional cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 25 cases. (9310954)
1997
45
Reactive arthritis associated with bacillus Calmette-GuAcrin immunotherapy for carcinoma of the bladder: immune reactivity against mycobacterial antigens. (8856640)
1996
46
Expression of human chorionic gonadotropin beta subunit genes in superficial and invasive bladder carcinomas. (7543817)
1995
47
Molecular and immunohistochemical evaluation of epidermal growth factor receptor and c-erb-B-2 gene product in transitional cell carcinomas of the urinary bladder: a study in Greek patients. (8539234)
1995
48
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
49
CARCINOMA OF THE BLADDER SIMULATING CHRONIC CYSTITIS. (14269353)
1965
50
Papillary carcinoma of a bladder diverticulum treated by transurethral resection. (18898744)
1948

Genetic Variations for Bladder Carcinoma

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Expression for genes affiliated with Bladder Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Carcinoma

Search GEO for disease gene expression data for Bladder Carcinoma.

Pathways for genes affiliated with Bladder Carcinoma

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51QIAGEN
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Pathways related to Bladder Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.9FGFR3, CDH1, NUDT6, AREG, JUP

Compounds for genes affiliated with Bladder Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Bladder Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1vegf4411.7JUP, AREG, ANG, MKI67, NUDT6, CDH1
2retinoic acid44 2412.7CGB7, AREG, H19, JUP, MKI67, MUC2
3tyrosine4411.7JUP, H19, AREG, ANG, MKI67, NUDT6
4paraffin4411.7SERPINB5, JUP, H19, MKI67, MUC2, CDH1
5serine4411.6JUP, AREG, MKI67, MUC2, NUDT6, CDH1
6progesterone44 59 28 11 2415.5AREG, CGB7, MKI67, MUC2, CDH1, KRT20
7cisplatin44 49 59 1114.4JUP, AREG, CGB7, MKI67, CDH1, TERC
8testosterone44 59 11 2414.4AREG, CGB7, MKI67, NUDT6, CDH1, KRT20
95-aza-2deoxycytidine4411.4JUP, H19, BAGE, MUC2, CDH1, SERPINB5
10agar4411.4JUP, H19, NUDT6, CDH1, TERC, TDGF1P3
11cysteine4411.2CGB7, MUC2, NUDT6, CDH1, FGFR3, SLC7A5
12doxorubicin44 49 1113.2MKI67, CDH1, FGFR3, KRT20, TERC
13thymidine44 2412.2TERC, NUDT6, MKI67, AREG, H19
14hematoxylin4411.2MKI67, MUC2, CDH1, KRT20
15p0024411.1JUP, MKI67, CDH1, SERPINB5
16methotrexate44 49 1113.1CGB7, MKI67, MUC2, CDH1
17calcium44 49 11 2414.1JUP, AREG, MKI67, MUC2, NUDT6, CDH1
185fluorouracil4411.1MKI67, MUC2, CDH1, TERC
19tamoxifen44 49 28 1114.1SERPINB5, TERC, CDH1, MKI67
20oligonucleotide4411.0JUP, AREG, MUC2, FGFR3, TERC
21pd 98,0594411.0AREG, MUC2, NUDT6, CDH1
22cytosine44 2411.9H19, CDH1, SERPINB5
23steroid4410.9SERPINB5, NUDT6, MKI67, H19
24alpha e4410.9CDH1, JUP
25azathioprine44 49 2 1113.9CDH1, MUC2, H19
26dexamethasone44 49 28 1113.8CDH1, MUC2, AREG, JUP
27hpaii4410.7MUC2, H19
28chi 24410.4MKI67, CDH1

GO Terms for genes affiliated with Bladder Carcinoma

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16Gene Ontology
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Cellular components related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:01634210.7CDH1, JUP
2internal side of plasma membraneGO:00989810.4FGFR3, CDH1, JUP

Biological processes related to Bladder Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cochlea developmentGO:09010210.7FGFR3, CDH1
2cellular response to indole-3-methanolGO:07168110.6CDH1, JUP
3morphogenesis of an epitheliumGO:00200910.4SERPINB5, FGFR3

Products for genes affiliated with Bladder Carcinoma

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  • Antibodies
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Sources for Bladder Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet