MCID: BLD044
MIFTS: 51

Bladder Disease malady

Nephrological diseases category

Summaries for Bladder Disease

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 The bladder is a hollow organ in your lower abdomen that stores urine. many conditions can affect your bladder. some common ones are cystitis - inflammation of the bladder, often from an infection urinary incontinence - loss of bladder control overactive bladder - a condition in which the bladder squeezes urine out at the wrong time interstitial cystitis - a chronic problem that causes bladder pain and frequent, urgent urination bladder cancer doctors diagnose bladder diseases using different tests. these include urine tests, x-rays, and an examination of the bladder wall with a scope called a cystoscope. treatment depends on the cause of the problem. it may include medicines and, in severe cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Bladder Disease, also known as bladder diseases, is related to prostatitis and cystitis. An important gene associated with Bladder Disease is TRPV1 (transient receptor potential cation channel, subfamily V, member 1), and among its related pathways is G alpha (q) signalling events. The drugs acetic acid and neostigmine and the compounds pge2 and menthol have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate.

Wikipedia:63 Urinary bladder disease can be congenital or acquired. more...

Aliases & Classifications for Bladder Disease

About this section
Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Bladder Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bladder Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.1KLK3
2cystitis29.7TRPV1
3pancreatitis29.7CCK
4bladder carcinoma29.7KLK3, PPIG, HBEGF
5obesity29.7HBEGF, TRPV1, PPIG, CCK
6neurogenic bladder10.4
7diabetes mellitus10.1
8intestinal disease10.1
9prostate disease10.1
10gallbladder disease10.0
11liver disease10.0
12neurologic diseases10.0
13esophagitis10.0TRPV1
14proctitis10.0KLK3
15dyspepsia10.0CCK
16lung cancer10.0PPIG
17irritable bowel syndrome10.0TRPV1, CCK
18urinary tract obstruction10.0KLK3, HBEGF
19cholera10.0CCK
20neuroma10.0TRPV1
21astrocytoma10.0IDO1, CHRM3
22psychotic disorder10.0CCK, IDO1
23gastroesophageal reflux disease10.0TRPV1, CCK
24gastrointestinal system disease10.0CCK, TRPV1, HBEGF
25gastritis10.0CCK, TRPV1, HBEGF
26adenoma10.0HBEGF, PPIG
27pain agnosia10.0CCK, CHRM3, TRPV1
28ischemia10.0HBEGF, TRPV1, PPIG
29glioblastoma multiforme10.0CCK, IDO1, HBEGF
30pancreatitis, chronic10.0PPIG, CCK
31lung small cell carcinoma10.0CHRM3, CCK, KLK3
32melanoma10.0HBEGF, PPIG, IDO1
33pulmonary disease, chronic obstructive10.0TRPV1, CHRM3, PPIG
34stomach cancer10.0HBEGF, PPIG, CCK
35asthma10.0IDO1, CHRM3, TRPV1, HBEGF
36adenocarcinoma10.0KLK3, CCK, IDO1, PPIG, TRPV1, HBEGF
37bacteriuria9.8
38duodenal ulcer9.8
39prostate calculus9.8
40diphyllobothriasis9.8
41alcoholic pancreatitis9.8
42appendicitis9.8
43duodenitis9.8
44polycystic liver disease9.8
45hemolytic-uremic syndrome9.8
46bladder calculus9.8
47bladder transitional cell carcinoma9.8
48duodenal disease9.8
49hemorrhagic disease9.8
50hepatitis9.8

Graphical network of the top 20 diseases related to Bladder Disease:



Diseases related to bladder disease

Clinical Features for Bladder Disease

About this section

Drugs & Therapeutics for Bladder Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bladder Disease

Drug clinical trials:

Search ClinicalTrials for Bladder Disease

Search NIH Clinical Center for Bladder Disease

Search CenterWatch for Bladder Disease

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Disease:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Disease:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Disease

About this section

Anatomical Context for Bladder Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Bladder Disease:

32
Kidney, Testes, Prostate, Heart, Spinal cord, Liver, Brain, Smooth muscle, Lung, Bone, Colon, Appendix

Animal Models for Bladder Disease or affiliated genes

About this section

Publications for Bladder Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Bladder Disease:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Is overactive bladder a brain disease? The pathophysiological role of cerebral white matter in the elderly. (24118122)
2014
2
IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. (23007803)
2012
3
Expression of microRNAs in urinary bladder samples obtained from dogs with grossly normal bladders, inflammatory bladder disease, or transitional cell carcinoma. (23013190)
2012
4
The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease. (22046200)
2011
5
Prevalence and characteristics associated with self-reported gall bladder disease in Mexican American elders: results from the Hispanic Established Populations for Epidemiologic Studies in the Elderly (H-EPESE). (19225267)
2009
6
Imaging appearance of granulomatous disease after intravesical Bacille Calmette-Guerin (BCG) treatment of bladder carcinoma. (19457810)
2009
7
Abnormal bladder mimicking proctitis on Tc-99m HMPAO leucocytes imaging for inflammatory bowel disease. (18936627)
2008
8
Peritoneal dialysis in a patient with neurogenic bladder and chronic kidney disease with ventriculoperitoneal shunt. (18417960)
2008
9
Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. (16105033)
2005
10
Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer. (16133558)
2005
11
Bladder carcinoma: understanding advanced and metastatic disease with potential molecular therapeutic targets. (16336092)
2005
12
Extracorporeal electromagnetic stimulation for urinary incontinence and bladder disease. (15088922)
2003
13
Malignant peripheral nerve sheath tumor of the urinary bladder in von Recklinghausen disease. (12187050)
2002
14
Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial. (11564042)
2001
15
Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. (10397272)
1999
16
Nitric oxide synthase expression in neurogenic bladder disease: a pilot study. (10218094)
1999
17
Diagnosis and localization of a complicated urinary tract infection in neurogenic bladder disease by tubular proteinuria and serum prostate specific antigen. (9471136)
1998
18
Risk factors for the development of gall bladder disease. (18668936)
1994
19
Comparison of CYFRA 21-1, TPA and TPS in lung cancer, urinary bladder cancer and benign diseases. (7523546)
1994
20
Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression. (7677935)
1993
21
p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression. (8217593)
1993
22
Superficial bladder disease: case studies and therapeutic advances. (1466118)
1992
23
Augmentation cystoplasty in the management of neurogenic bladder disease and urinary incontinence. (3959250)
1986
24
Neurogenic bladder in Legionnaires' disease. (3706359)
1986
25
Periurethral polytetrafluoroethylene injections in incontinent female subjects with neurogenic bladder disease. (6538241)
1984
26
Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics. (7166683)
1982
27
Acalculous gall-bladder disease. (4693572)
1973
28
Gall bladder disease in childhood. (4642203)
1972
29
A sign of gall-bladder disease. (5431086)
1970
30
Bladder symptoms due to silent sigmoid disease. (5791049)
1969
31
Vesicostomy in the management of neurogenic bladder disease secondary to meningomyelocele in children. (5923299)
1966
32
Gall bladder disease in children. (13978306)
1963
33
PERICYSTITIS AND CASES OF PERICYSTITIS SIMULATING MALIGNANT BLADDER DISEASE. (14135515)
1963
34
Gastrointestinal-tract hemorrhage due to gall-bladder disease. (13632912)
1959
35
Incidence of gall bladder disease in normal men. (13620038)
1959
36
Rokitansky-Aschoff sinuses as a presumptive x-ray sign of gall bladder disease. (13410321)
1957
37
Diaphragmatic hernia associated with other gastro-intestinal and gall bladder disease. (18875479)
1948
38
Biliary stasis; the basis of most gall bladder disease. (18106386)
1948
39
Blood bilirubin determinations as aids in differentiating chronic gall bladder disease and peptic ulcer. (18874807)
1948
40
On the so-called gall bladder disease. (20267322)
1947
41
The medical treatment of gall bladder disease. (21001694)
1946
42
Early determination of gall bladder disease and its treatment. (21019023)
1946
43
Acute gall bladder disease in the aged. (20279430)
1946
44
The Clinical Pathology of Gall-Bladder Disease. (21313354)
1944
45
The Clinical Diagnosis of Chronic Gall-Bladder Disease. (21313356)
1944
46
THE ASSOCIATION OF GALL-BLADDER DISEASE WITH CARDIAC LESIONS. (20320996)
1938
47
THE IMPORTANCE OF EARLIER OPERATION IN CHRONIC GALL-BLADDER DISEASE. (20320747)
1937
48
THE X-RAY IN THE DIAGNOSIS OF GALL BLADDER DISEASE. (20319262)
1933
49
Surgical Treatment of Gall-Bladder Disease. (18736004)
1913
50
The Medical Treatment of Gall-Bladder Disease. (18735979)
1913

Genetic Variations for Bladder Disease

About this section

Expression for genes affiliated with Bladder Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bladder Disease

Search GEO for disease gene expression data for Bladder Disease.

Pathways for genes affiliated with Bladder Disease

About this section
Sources:
53Reactome
See all sources

Pathways related to Bladder Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.9HBEGF, CHRM3, CCK

Compounds for genes affiliated with Bladder Disease

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Bladder Disease according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pge24410.5TRPV1
2menthol44 28 11 2413.0TRPV1, IDO1
3aspartame44 11 2412.0TRPV1, CCK
4phorbol 12,13-dibutyrate449.8CHRM3, TRPV1
5dtpa449.8KLK3, CCK
64-diphenylacetoxy-n-methylpiperidine methiodide449.7CCK, CHRM3
7bethanechol44 28 1111.7CHRM3, CCK
8lidocaine44 28 1111.7TRPV1, CHRM3
9cyproheptadine28 44 1111.7CHRM3, CCK
10pirenzepine44 28 1111.7CCK, CHRM3
11l-nmma449.6CCK, IDO1
12nicardipine28 44 1111.6CCK, CHRM3
13tetrodotoxin44 59 2811.6CCK, TRPV1
14lauric acid44 2810.5CCK, PPIG
15amide449.5TRPV1, CCK
16atropine44 28 1111.4CCK, CHRM3
17terfenadine44 28 1111.4CHRM3, PPIG
18coumarin44 2 49 2412.4KLK3, PPIG
19omeprazole44 28 49 11 2413.4CCK, PPIG
20nortriptyline44 49 28 1112.3CHRM3, PPIG
21ziprasidone49 28 44 1112.3CHRM3, PPIG
22quinine44 28 2 1112.3PPIG, IDO1
23ketoconazole44 28 11 2412.3KLK3, PPIG
24polysaccharide449.3HBEGF, CCK, KLK3
25cycloheximide449.1KLK3, IDO1, HBEGF
26glutamate449.0HBEGF, CCK, TRPV1, IDO1
27adenylate448.7TRPV1, CHRM3, CCK
28testosterone44 59 11 2411.6HBEGF, PPIG, CCK, KLK3
29cyclosporin a44 28 5910.5CHRM3, TRPV1, CCK, PPIG
30tyrosine448.4CHRM3, TRPV1, HBEGF, CCK, IDO1
31calcium44 49 11 2411.3IDO1, CHRM3, CCK, TRPV1, HBEGF
32dexamethasone44 49 28 1111.1HBEGF, PPIG, IDO1, CCK, KLK3

GO Terms for genes affiliated with Bladder Disease

About this section

Products for genes affiliated with Bladder Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet