MCID: BLD044
MIFTS: 45

Bladder Disease malady

Nephrological category

Summaries for Bladder Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 The bladder is a hollow organ in your lower abdomen that stores urine. many conditions can affect your bladder. some common ones are cystitis - inflammation of the bladder, often from an infection urinary incontinence - loss of bladder control overactive bladder - a condition in which the bladder squeezes urine out at the wrong time interstitial cystitis - a chronic problem that causes bladder pain and frequent, urgent urination bladder cancer doctors diagnose bladder diseases using different tests. these include urine tests, x-rays, and an examination of the bladder wall with a scope called a cystoscope. treatment depends on the cause of the problem. it may include medicines and, in severe cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Bladder Disease, also known as bladder diseases, is related to bladder carcinoma and neurogenic bladder. An important gene associated with Bladder Disease is TRPV1 (transient receptor potential cation channel, subfamily V, member 1), and among its related pathways is G alpha (q) signalling events. The drugs acetic acid and neostigmine and the compounds pge2 and menthol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart.

Wikipedia:64 Urinary bladder disease can be congenital or acquired. more...

Aliases & Classifications for Bladder Disease

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Bladder Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bladder Disease:



Diseases related to bladder disease

Clinical Features for Bladder Disease

Drugs & Therapeutics for Bladder Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bladder Disease

Drug clinical trials:

Search ClinicalTrials for Bladder Disease

Search NIH Clinical Center for Bladder Disease

Search CenterWatch for Bladder Disease

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Disease:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Disease:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Disease

Anatomical Context for Bladder Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Bladder Disease:

33
Brain, Spinal cord, Heart, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Prostate, B cells, Appendix

Animal Models for Bladder Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Bladder Disease

Sources:
51PubMed
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Articles related to Bladder Disease:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. (24261777)
2014
2
Neurogenic bladder in lyme disease. (23346488)
2012
3
RUNX3 methylation as a predictor for disease progression in patients with non-muscle-invasive bladder cancer. (22311819)
2012
4
The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease. (22046200)
2011
5
Is radical oncosurgery justified for the treatment of primary malignant fibrous histiocytoma of the urinary bladder? Report of two cases and analyses of disease-specific survival rates based on a review of the literature. (21266796)
2011
6
Preoperative hydronephrosis predicts extravesical and node positive disease in patients undergoing cystectomy for bladder cancer. (20299043)
2010
7
Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once-daily administration of trospium chloride extended release. (19634167)
2010
8
Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. (19188175)
2009
9
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. (18607595)
2009
10
Overactive bladder disease: the urge for better therapies. (18500915)
2008
11
Effects of milnacipran and paroxetine on overactive bladder due to neurologic diseases: a urodynamic assessment. (18931554)
2008
12
Urinary bladder paraganglioma in a case of von Hippel-Lindau disease. (17875164)
2007
13
Association of cyclin D1 and E1 expression with disease progression and biomarkers in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder. (18047954)
2007
14
Bladder and bowel symptoms among women with vulvar disease: are they universal? (18210896)
2007
15
Association of cyclooxygenase-2 immunoreactivity with tumor recurrence and disease progression in superficial urothelial bladder cancer. (16724691)
2006
16
Focal S100A4 protein expression is an independent predictor of development of metastatic disease in cystectomized bladder cancer patients. (16632178)
2006
17
Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders. (16470209)
2006
18
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. (16474624)
2005
19
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients. (11948103)
2002
20
Bladder disease: A report based on the smooth muscle function in health and disease satellite meeting to the International Congress of Physiology. (12734603)
2001
21
EAU - 15th Congress. Urinary incontinence and bladder disease. (16080050)
2000
22
Review article: epidemiology of gall-bladder disease--role of intestinal transit. (10902996)
2000
23
Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. (10397272)
1999
24
Reduced expression of E-cadherin is related to invasive disease and frequent recurrence in bladder cancer. (7768969)
1995
25
Risk factors for symptomatic gall bladder disease. (7959216)
1994
26
Is gallbladder ejection fraction a reliable predictor of acalculous gall bladder disease? (8321495)
1993
27
Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease. (2925272)
1989
28
Parathyroid hormone like bioactivity measured by cytochemical bioassay in a patient with malignant bladder disease. (3248932)
1988
29
Painful bladder disease: clinical and pathoanatomical differences in 115 patients. (3625848)
1987
30
Prostatic hypertrophy and venereal disease as possible risk factors in the development of bladder cancer. (6191422)
1983
31
Bladder neuropathy in lumbar disc disease. (463603)
1979
32
Re-evaluation of differential sacral rhizotomy for neurological bladder disease. (417152)
1978
33
Letter: Oral cholecystography: a sign of gall-bladder disease. (1120236)
1975
34
Gall-bladder disease in childhood. (5085029)
1972
35
GALL BLADDER DISEASE IN NIGERIA. A FIVE-YEAR REVIEW. (14206701)
1964
36
GALL BLADDER DISEASE AND DUODENAL ULCER. (14238699)
1964
37
THE CONTROL OF ENURESIS WITH IMIPRAMINE IN THE PRESENCE OF ORGANIC BLADDER DISEASE. (14129296)
1964
38
Some observations on the pathology of congenital idiopathic bladder-neck obstruction (Marion's disease). (13489235)
1957
39
Gall bladder disease. (13406501)
1957
40
Gall bladder disease in a seven-and-one-half-year-old child. (13188455)
1954
41
Some clinical features of chronic gall bladder disease. (13034051)
1953
42
Diabetes mellitus and gall bladder disease. (20291358)
1947
43
The Surgery of Gall-Bladder Disease. (21313357)
1944
44
Gall Bladder Disease: Etiology, Diagnosis and Treatment. (19312306)
1943
45
Surgical Aspects of Gall-bladder Disease. (17866581)
1931
46
GALL BLADDER DISEASE. (20316483)
1927
47
Gassy Indigestion: Its Significance as a Symptom of Gall Bladder Disease, With a Review of Sixty Cases of Cholecystectomy. (20315666)
1926
48
THE MELTZER-LYONS TEST IN THE DIAGNOSIS OF GALL-BLADDER DISEASE. (17864926)
1923
49
GALL-BLADDER DISEASE IN CHILDHOOD. (17864826)
1923
50
XII. Strangulation Resulting from Distention of Hollow Viscera: Its Bearing Upon Appendicitis, Strangulated Hernia and Gall-Bladder Disease. (17862071)
1907

Genetic Variations for Bladder Disease

Expression for genes affiliated with Bladder Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Disease

Search GEO for disease gene expression data for Bladder Disease.

Pathways for genes affiliated with Bladder Disease

Sources:
54Reactome
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Pathways related to Bladder Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.9HBEGF, CHRM3, CCK

Compounds for genes affiliated with Bladder Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
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Compounds related to Bladder Disease according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pge24510.5TRPV1
2menthol45 29 11 2413.0TRPV1, IDO1
3aspartame45 11 2412.0TRPV1, CCK
4phorbol 12,13-dibutyrate459.8CHRM3, TRPV1
5dtpa459.8KLK3, CCK
64-diphenylacetoxy-n-methylpiperidine methiodide459.7CCK, CHRM3
7bethanechol45 29 1111.7CHRM3, CCK
8lidocaine45 29 1111.7TRPV1, CHRM3
9cyproheptadine29 45 1111.7CHRM3, CCK
10pirenzepine45 29 1111.7CCK, CHRM3
11l-nmma459.6CCK, IDO1
12nicardipine29 45 1111.6CCK, CHRM3
13tetrodotoxin45 60 2911.6CCK, TRPV1
14lauric acid45 2910.5CCK, PPIG
15amide459.5TRPV1, CCK
16atropine45 29 1111.4CCK, CHRM3
17terfenadine45 29 1111.4CHRM3, PPIG
18coumarin45 2 50 2412.4KLK3, PPIG
19omeprazole45 29 50 11 2413.4CCK, PPIG
20nortriptyline45 50 29 1112.3CHRM3, PPIG
21ziprasidone50 29 45 1112.3CHRM3, PPIG
22quinine45 29 2 1112.3PPIG, IDO1
23ketoconazole45 29 11 2412.3KLK3, PPIG
24polysaccharide459.3HBEGF, CCK, KLK3
25cycloheximide459.1KLK3, IDO1, HBEGF
26glutamate459.0HBEGF, CCK, TRPV1, IDO1
27adenylate458.7TRPV1, CHRM3, CCK
28testosterone45 60 11 2411.6HBEGF, PPIG, CCK, KLK3
29cyclosporin a45 29 6010.5CHRM3, TRPV1, CCK, PPIG
30tyrosine458.4CHRM3, TRPV1, HBEGF, CCK, IDO1
31calcium45 50 11 2411.3IDO1, CHRM3, CCK, TRPV1, HBEGF
32dexamethasone45 50 29 1111.1HBEGF, PPIG, IDO1, CCK, KLK3

GO Terms for genes affiliated with Bladder Disease

Products for genes affiliated with Bladder Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet