MCID: BLD044
MIFTS: 51

Bladder Disease malady

Nephrological diseases category

Summaries for Bladder Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The bladder is a hollow organ in your lower abdomen that stores urine. many conditions can affect your bladder. some common ones are cystitis - inflammation of the bladder, often from an infection urinary incontinence - loss of bladder control overactive bladder - a condition in which the bladder squeezes urine out at the wrong time interstitial cystitis - a chronic problem that causes bladder pain and frequent, urgent urination bladder cancer doctors diagnose bladder diseases using different tests. these include urine tests, x-rays, and an examination of the bladder wall with a scope called a cystoscope. treatment depends on the cause of the problem. it may include medicines and, in severe cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Bladder Disease, also known as bladder diseases, is related to prostatitis and cystitis. An important gene associated with Bladder Disease is TRPV1 (transient receptor potential cation channel, subfamily V, member 1), and among its related pathways is G alpha (q) signalling events. The drugs acetic acid and neostigmine and the compounds pge2 and menthol have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate.

Wikipedia:63 Urinary bladder disease can be congenital or acquired. more...

Aliases & Classifications for Bladder Disease

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Bladder Disease

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17GeneCards, 18GeneDecks
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Diseases related to Bladder Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.1KLK3
2cystitis29.7TRPV1
3pancreatitis29.7CCK
4bladder carcinoma29.7KLK3, PPIG, HBEGF
5obesity29.7HBEGF, TRPV1, PPIG, CCK
6neurogenic bladder10.4
7diabetes mellitus10.1
8intestinal disease10.1
9prostate disease10.1
10gallbladder disease10.0
11liver disease10.0
12neurologic diseases10.0
13esophagitis10.0TRPV1
14proctitis10.0KLK3
15dyspepsia10.0CCK
16lung cancer10.0PPIG
17irritable bowel syndrome10.0TRPV1, CCK
18urinary tract obstruction10.0KLK3, HBEGF
19cholera10.0CCK
20neuroma10.0TRPV1
21astrocytoma10.0IDO1, CHRM3
22psychotic disorder10.0CCK, IDO1
23gastroesophageal reflux disease10.0TRPV1, CCK
24gastrointestinal system disease10.0CCK, TRPV1, HBEGF
25gastritis10.0CCK, TRPV1, HBEGF
26adenoma10.0HBEGF, PPIG
27pain agnosia10.0CCK, CHRM3, TRPV1
28ischemia10.0HBEGF, TRPV1, PPIG
29glioblastoma multiforme10.0CCK, IDO1, HBEGF
30pancreatitis, chronic10.0PPIG, CCK
31lung small cell carcinoma10.0CHRM3, CCK, KLK3
32melanoma10.0HBEGF, PPIG, IDO1
33pulmonary disease, chronic obstructive10.0TRPV1, CHRM3, PPIG
34stomach cancer10.0HBEGF, PPIG, CCK
35asthma10.0IDO1, CHRM3, TRPV1, HBEGF
36adenocarcinoma10.0KLK3, CCK, IDO1, PPIG, TRPV1, HBEGF
37bacteriuria9.8
38duodenal ulcer9.8
39prostate calculus9.8
40diphyllobothriasis9.8
41alcoholic pancreatitis9.8
42appendicitis9.8
43duodenitis9.8
44polycystic liver disease9.8
45hemolytic-uremic syndrome9.8
46bladder calculus9.8
47bladder transitional cell carcinoma9.8
48duodenal disease9.8
49hemorrhagic disease9.8
50hepatitis9.8

Graphical network of the top 20 diseases related to Bladder Disease:



Diseases related to bladder disease

Clinical Features for Bladder Disease

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Drugs & Therapeutics for Bladder Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bladder Disease

Drug clinical trials:

Search ClinicalTrials for Bladder Disease

Search NIH Clinical Center for Bladder Disease

Search CenterWatch for Bladder Disease

Inferred drug relations via UMLS60/NDF-RT40:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Disease:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Disease:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Disease

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Anatomical Context for Bladder Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Bladder Disease:

32
Kidney, Testes, Prostate, Heart, Spinal cord, Liver, Brain, Smooth muscle, Lung, Bone, Colon, Appendix

Animal Models for Bladder Disease or affiliated genes

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Publications for Bladder Disease

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50PubMed
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Articles related to Bladder Disease:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
The association of pioglitazone and urinary tract disease in type 2 diabetic taiwanese: bladder cancer and chronic kidney disease. (24427312)
2014
2
Re: 'Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: An uncommon cause of severe urological disease in an infant' J Pediatr Urol 2013 Feb 4 [Epub ahead of print]. (23973761)
2013
3
Neurofibromas of the bladder in a child with neurofibromatosis type 1 causing chronic renal disease. (23815393)
2013
4
Remodeling of the muscle layer (detrusor muscle) of hyperactive bladder disease in patients with benign prostatic hyperplasia. (23113284)
2012
5
Secondary extramammary Paget's disease with underlying recurrent bladder carcinoma. (22257834)
2012
6
A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. (21855919)
2011
7
Re: preoperative hydronephrosis predicts extravesical and node positive disease in patients undergoing cystectomy for bladder cancer. C. J. Stimson, M. S. Cookson, D. A. Barocas, P. E. Clark, J. E. Humphrey, S. G. Patel, J. A. Smith, Jr. and S. S. Chang. J Urol 2010; 183: 1732-1737. (21334665)
2011
8
In-depth investigation of the molecular pathogenesis of bladder cancer in a unique 26-year old patient with extensive multifocal disease: a case report. (20187926)
2010
9
Annexin-I overexpression is associated with tumour progression and independently predicts inferior disease-specific and metastasis-free survival in urinary bladder urothelial carcinoma. (20025479)
2010
10
Identification of S100A8-correlated genes for prediction of disease progression in non-muscle invasive bladder cancer. (20096140)
2010
11
A case of Pott's disease with epidural abscess and probable cerebral tuberculoma following Bacillus Calmette-GuAcrin therapy for superficial bladder cancer. (21358881)
2010
12
Excision of massive bladder diverticula in Menkes disease. (19713155)
2010
13
Tubercular disease caused by Bacillus of Calmette-GuAcrin as a local adjuvant treatment of relapsing bladder carcinoma. (19877893)
2009
14
High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. (19878561)
2009
15
Tissue factor expression correlates with disease-specific survival in patients with node-negative muscle-invasive bladder cancer. (18058798)
2008
16
Intravenous urography for diagnosing synchronous upper-tract tumours in patients with newly diagnosed bladder carcinoma can be restricted to patients with high-risk superficial disease. (17662732)
2007
17
Preoperative somatic symptoms are associated with disease progression in patients with bladder carcinoma after cystectomy. (15476276)
2004
18
Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer. (12429155)
2002
19
Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence. (11796313)
2002
20
Neurogenic bladder dysfunction due to BehAset's disease. (10466456)
1999
21
Latex allergy in subjects who had undergone multiple surgical procedures for bladder exstrophy: relationship with clinical intervention and atopic diseases. (10571636)
1999
22
Gall bladder disease and ABO blood group. (10456157)
1997
23
Cigarette smoking and parity as risk factors for the development of symptomatic gall bladder disease in women: results of the Royal College of General Practitioners' oral contraception study. (8307429)
1994
24
Is beta-human chorionic gonadotrophin production by transitional cell carcinoma of the bladder a marker of aggressive disease and resistance to radiotherapy? (7508330)
1993
25
Hemobilia due to vasculitis of the gall bladder in a patient with mixed connective tissue disease. (2066956)
1991
26
Disorders of bladder function in spinal cord disease. (1921955)
1991
27
Gall bladder disease: an analytical report of 250 cases. (2634700)
1989
28
A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease. (2442415)
1987
29
Diagnosing gall bladder disease. (6428671)
1984
30
The fatty meal and acalculous gall-bladder disease. (6467829)
1984
31
Gall bladder disease pattern in Punjab. (6481174)
1984
32
HIDA scanning in gall-bladder disease. (7437710)
1980
33
Immunosurveillance in pre-malignant occupational bladder disease. (86524)
1979
34
The use of sacral nerve blocks in the evaluation and treatment of neurologic bladder disease. (904050)
1977
35
The history and physical examination in neurogenic bladder disease. (4428538)
1974
36
The investigation of gall-bladder disease. (4718310)
1973
37
GALL-BLADDER DISEASE IN CHILDHOOD. (14262733)
1964
38
CHOLECYSTOGASTROSTOMY IN GALL BLADDER DISEASE. (14062626)
1963
39
Gall bladder disease, a radiological and pathological study. (13736791)
1961
40
The relationship between heart disease and gall-bladder disease. (13650430)
1959
41
Inheritance of gall-bladder disease. (14406276)
1959
42
Chronic gall bladder disease. (13584673)
1958
43
Acute gall-bladder disease and the common duct. (14349493)
1955
44
Practical management of gall bladder disease and its complications. (13149580)
1954
45
Appendix and gall-bladder disease, appendicular cholecystalgia. A new theory. (13070293)
1953
46
Liver damage in gall bladder disease. (20258027)
1947
47
Bladder-neck obstruction due to non-malignant disease of the prostate. (21006115)
1945
48
The Physician's Interest in Gall-Bladder Disease. (20322024)
1941
49
Gastro-Intestinal Symptoms Masking Gall-Bladder Disease. (18740576)
1928
50
The Symptomatology of Gall-Bladder Disease. (18736005)
1913

Genetic Variations for Bladder Disease

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Expression for genes affiliated with Bladder Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Disease

Search GEO for disease gene expression data for Bladder Disease.

Pathways for genes affiliated with Bladder Disease

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53Reactome
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Pathways related to Bladder Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.9HBEGF, CHRM3, CCK

Compounds for genes affiliated with Bladder Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Bladder Disease according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pge24410.5TRPV1
2menthol44 28 11 2413.0IDO1, TRPV1
3aspartame44 11 2412.0CCK, TRPV1
4phorbol 12,13-dibutyrate449.8CHRM3, TRPV1
5dtpa449.8CCK, KLK3
64-diphenylacetoxy-n-methylpiperidine methiodide449.7CHRM3, CCK
7bethanechol44 28 1111.7CHRM3, CCK
8lidocaine44 28 1111.7TRPV1, CHRM3
9cyproheptadine28 44 1111.7CHRM3, CCK
10pirenzepine44 28 1111.7CCK, CHRM3
11l-nmma449.6CCK, IDO1
12nicardipine28 44 1111.6CHRM3, CCK
13tetrodotoxin44 59 2811.6CCK, TRPV1
14lauric acid44 2810.5PPIG, CCK
15amide449.5TRPV1, CCK
16atropine44 28 1111.4CHRM3, CCK
17terfenadine44 28 1111.4CHRM3, PPIG
18coumarin44 2 49 2412.4PPIG, KLK3
19omeprazole44 28 49 11 2413.4PPIG, CCK
20nortriptyline44 49 28 1112.3CHRM3, PPIG
21ziprasidone49 28 44 1112.3CHRM3, PPIG
22quinine44 28 2 1112.3PPIG, IDO1
23ketoconazole44 28 11 2412.3PPIG, KLK3
24polysaccharide449.3KLK3, CCK, HBEGF
25cycloheximide449.1HBEGF, IDO1, KLK3
26glutamate449.0CCK, IDO1, TRPV1, HBEGF
27adenylate448.7TRPV1, CHRM3, CCK
28testosterone44 59 11 2411.6KLK3, CCK, PPIG, HBEGF
29cyclosporin a44 28 5910.5CCK, PPIG, CHRM3, TRPV1
30tyrosine448.4CCK, IDO1, CHRM3, TRPV1, HBEGF
31calcium44 49 11 2411.3CCK, IDO1, CHRM3, TRPV1, HBEGF
32dexamethasone44 49 28 1111.1HBEGF, PPIG, IDO1, CCK, KLK3

GO Terms for genes affiliated with Bladder Disease

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Products for genes affiliated with Bladder Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet