MCID: BLD044
MIFTS: 53

Bladder Disease malady

Nephrological diseases category
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Summaries for Bladder Disease

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 The bladder is a hollow organ in your lower abdomen that stores urine. many conditions can affect your bladder. some common ones are cystitis - inflammation of the bladder, often from an infection urinary incontinence - loss of bladder control overactive bladder - a condition in which the bladder squeezes urine out at the wrong time interstitial cystitis - a chronic problem that causes bladder pain and frequent, urgent urination bladder cancer doctors diagnose bladder diseases using different tests. these include urine tests, x-rays, and an examination of the bladder wall with a scope called a cystoscope. treatment depends on the cause of the problem. it may include medicines and, in severe cases, surgery. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Bladder Disease, also known as bladder diseases, is related to cystitis and pancreatic cancer. An important gene associated with Bladder Disease is CCK (cholecystokinin), and among its related pathways are Transcription Androgen Receptor nuclear signaling and Cell adhesion ECM remodeling. The drugs acetic acid and neostigmine and the compounds dtpa and l-nmma have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and heart, and related mouse phenotype homeostasis/metabolism.

Wikipedia:65 Urinary bladder disease can be congenital or acquired. more...

Aliases & Classifications for Bladder Disease

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Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Related Diseases for Bladder Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bladder Disease:



Diseases related to bladder disease

Symptoms for Bladder Disease

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Drugs & Therapeutics for Bladder Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bladder Disease

Search NIH Clinical Center for Bladder Disease

Inferred drug relations via UMLS62/NDF-RT41:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bladder Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bladder Disease:
Neo-Urinary Conduit
Embryonic/Adult Cultured Cells Related to Bladder Disease:
Neo-Urinary Conduit, PMID: 22136657

Genetic Tests for Bladder Disease

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Anatomical Context for Bladder Disease

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33MalaCards
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MalaCards organs/tissues related to Bladder Disease:

33
Testes, Kidney, Heart, Prostate, Liver, Smooth muscle, Appendix

Animal Models for Bladder Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Bladder Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6TRPV1, CCK, CHRM3, HBEGF, IDO1

Publications for Bladder Disease

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52PubMed
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Articles related to Bladder Disease:

(show top 50)    (show all 155)
idTitleAuthorsYear
1
Remodeling of the muscle layer (detrusor muscle) of hyperactive bladder disease in patients with benign prostatic hyperplasia. (23113284)
2012
2
Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome. (22077972)
2011
3
The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease. (22046200)
2011
4
A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. (21855919)
2011
5
Overactive bladder disease: the urge for better therapies. (18500915)
2008
6
TRPs in bladder diseases. (17560087)
2007
7
EAU - 15th Congress. Urinary incontinence and bladder disease. (16080050)
2000
8
Long-term follow-up after clam ileocystoplasty. Complications and results including some quality-of-life parameters for 32 patients treated for neuropathic and nonneuropathic bladder disease. (8178380)
1994
9
Is gallbladder ejection fraction a reliable predictor of acalculous gall bladder disease? (8321495)
1993
10
Superficial bladder disease: case studies and therapeutic advances. (1466118)
1992
11
Gall bladder disease as seen in a Harare referral hospital centre. (2225019)
1990
12
Gall bladder disease: an analytical report of 250 cases. (2634700)
1989
13
Parathyroid hormone like bioactivity measured by cytochemical bioassay in a patient with malignant bladder disease. (3248932)
1988
14
A critical reappraisal of cystometry in neurogenic bladder diseases. (3686758)
1987
15
Urine eosinophil cationic protein in painful bladder disease. (3304514)
1987
16
Augmentation cystoplasty in the management of neurogenic bladder disease and urinary incontinence. (3959250)
1986
17
Imaging procedures to diagnose gall bladder disease. (6426669)
1984
18
Diagnosing gall bladder disease. (6428671)
1984
19
Significance of asymptomatic bacteriuria in neurogenic bladder disease. (6369712)
1984
20
The fatty meal and acalculous gall-bladder disease. (6467829)
1984
21
Risk factors for gall-bladder disease: a cohort study of young women attending family planning clinics. (7166683)
1982
22
HIDA scanning in gall-bladder disease. (7437710)
1980
23
Polycystic liver and other hepatic masses mimicking gall-bladder disease. (519149)
1979
24
The use of sacral nerve blocks in the evaluation and treatment of neurologic bladder disease. (904050)
1977
25
Classification of neurogenic bladder disease. (4428539)
1974
26
Gall bladder disease in childhood. (4642203)
1972
27
Gall bladder disease in children. (13978306)
1963
28
CHOLECYSTOGASTROSTOMY IN GALL BLADDER DISEASE. (14062626)
1963
29
Radiological diagnosis of gall bladder disease. (13946048)
1962
30
Myocardial infarction versus gall bladder disease. (13793640)
1960
31
The relationship between heart disease and gall-bladder disease. (13650430)
1959
32
Chronic gall bladder disease. (13584673)
1958
33
Gall bladder disease. (13406501)
1957
34
Gall bladder disease. (13184295)
1954
35
Practical management of gall bladder disease and its complications. (13149580)
1954
36
Diaphragmatic hernia associated with other gastro-intestinal and gall bladder disease. (18875479)
1948
37
Biliary stasis; the basis of most gall bladder disease. (18106386)
1948
38
On the so-called gall bladder disease. (20267322)
1947
39
Liver damage in gall bladder disease. (20258027)
1947
40
Diagnosis and medical management of gall bladder disease. (20259872)
1947
41
Early determination of gall bladder disease and its treatment. (21019023)
1946
42
The Clinical Pathology of Gall-Bladder Disease. (21313354)
1944
43
THE ASSOCIATION OF GALL-BLADDER DISEASE WITH CARDIAC LESIONS. (20320996)
1938
44
On the Mortality Resulting from Surgical Treatment of Chronic Gall-bladder Disease in Diabetes Mellitus. (17866803)
1932
45
OBSCURE GALL-BLADDER DISEASE. (18741249)
1929
46
Gassy Indigestion: Its Significance as a Symptom of Gall Bladder Disease, With a Review of Sixty Cases of Cholecystectomy. (20315666)
1926
47
THE MELTZER-LYONS TEST IN THE DIAGNOSIS OF GALL-BLADDER DISEASE. (17864926)
1923
48
GALL-BLADDER DISEASE IN CHILDHOOD. (17864826)
1923
49
IS THE MELTZER-LYON TECHNIC FOR THE DIAGNOSIS AND TREATMENT OF GALL BLADDER DISEASE AN ASSET OR A LIABILITY? (18738767)
1922
50
The Symptomatology of Gall-Bladder Disease. (18736005)
1913

Variations for Bladder Disease

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Expression for genes affiliated with Bladder Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Disease

Search GEO for disease gene expression data for Bladder Disease.

Pathways for genes affiliated with Bladder Disease

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Sources:
50PathCards, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Bladder Disease

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Bladder Disease according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1dtpa459.9KLK3, CCK
2l-nmma459.9CCK, IDO1
34-diphenylacetoxy-n-methylpiperidine methiodide459.9CCK, CHRM3
4sulfate45 2410.9CCK, HBEGF
5bethanechol45 29 1111.9CCK, CHRM3
6cyproheptadine45 29 1111.8CHRM3, CCK
7pirenzepine45 29 1111.8CCK, CHRM3
8nicardipine45 29 1111.8CCK, CHRM3
9suramin45 29 1111.8KLK3, HBEGF
10atropine45 29 1111.8CHRM3, CCK
115-hydroxytryptamine459.8IDO1, CCK
12carbachol45 29 1111.7CCK, CHRM3
13aspartame45 24 1111.7CCK, TRPV1
14tetrodotoxin45 61 2911.6TRPV1, CCK
15inositol 1,4,5 trisphosphate459.6CCK, CHRM3
16amide459.6TRPV1, CCK
17menthol45 29 24 1112.5IDO1, TRPV1
18morphine45 51 29 1112.5TRPV1, CCK
19cgmp45 2910.5CHRM3, IDO1
20polysaccharide459.5HBEGF, CCK, KLK3
21phorbol 12,13-dibutyrate459.4TRPV1, CHRM3
22lidocaine45 29 1111.4CHRM3, TRPV1
23testosterone45 61 24 1112.4HBEGF, CCK, KLK3
24cycloheximide459.3KLK3, HBEGF, IDO1
25formaldehyde45 2410.3KLK3, TRPV1
26thapsigargin45 6110.2TRPV1, CCK
27inositol459.2TRPV1, CHRM3
28cyclosporin a45 29 6111.0TRPV1, CCK, CHRM3
29dexamethasone45 51 29 1112.0IDO1, HBEGF, CCK, KLK3
30adenylate459.0CHRM3, CCK, TRPV1
31nitric oxide45 24 1110.9IDO1, HBEGF, TRPV1
32oxygen45 249.7IDO1, HBEGF, TRPV1
33glucose458.7CCK, CHRM3, HBEGF
34pge2458.7TRPV1, CCK, HBEGF, IDO1
35glutamate458.7TRPV1, CCK, HBEGF, IDO1
36atp45 299.6TRPV1, CHRM3, HBEGF
37cysteine458.5HBEGF, CHRM3, TRPV1
38tyrosine458.1IDO1, HBEGF, CHRM3, CCK, TRPV1
39calcium45 51 24 1111.0IDO1, HBEGF, CHRM3, CCK, TRPV1

GO Terms for genes affiliated with Bladder Disease

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16Gene Ontology
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Cellular components related to Bladder Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:0452119.0TRPV1, CHRM3
2integral component of plasma membraneGO:0058878.3TRPV1, CHRM3, HBEGF

Biological processes related to Bladder Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:0071659.0CCK, CHRM3, HBEGF

Products for genes affiliated with Bladder Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bladder Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet