MCID: BLD009
MIFTS: 36

Bladder Neck Obstruction

Categories: Nephrological diseases

Aliases & Classifications for Bladder Neck Obstruction

MalaCards integrated aliases for Bladder Neck Obstruction:

Name: Bladder Neck Obstruction 12 14 69
Obstruction of Bladder Neck or Vesicourethral Orifice 12
Urinary Bladder Neck Obstruction 42

Classifications:



External Ids:

Disease Ontology 12 DOID:13948
ICD10 33 N32.0
ICD9CM 35 596.0
MeSH 42 D001748
NCIt 47 C79541
UMLS 69 C0005694

Summaries for Bladder Neck Obstruction

MalaCards based summary : Bladder Neck Obstruction, also known as obstruction of bladder neck or vesicourethral orifice, is related to mononeuritis of upper limb and cystoisosporiasis. An important gene associated with Bladder Neck Obstruction is SIRPA (Signal Regulatory Protein Alpha), and among its related pathways/superpathways are Adhesion and FOXA2 and FOXA3 transcription factor networks. The drugs Fesoterodine and Tamsulosin have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and testes, and related phenotype is behavior/neurological.

Related Diseases for Bladder Neck Obstruction

Diseases related to Bladder Neck Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 mononeuritis of upper limb 10.6 KLK3 SIRPA
2 cystoisosporiasis 10.6 HCCS SAMHD1
3 dermatitis 10.5 HCCS SAMHD1
4 hairy tongue 10.5 KLK3 SAMHD1
5 esotropia 10.4 SAMHD1 TTR
6 neuronitis 10.4 ACPP KLK3
7 hemopericardium 10.3 TAC1 TTR
8 fibular collateral ligament bursitis 10.3 F3 KLK3
9 lobomycosis 10.3 F3 SIRPA
10 brain glioblastoma multiforme 10.3 KLK3 TAC1
11 bagassosis 10.3 AFP KLK3
12 sphenoid sinus squamous cell carcinoma 10.3 AFP KLK3
13 cerebellar vermis medulloblastoma 10.2 AFP KLK3
14 ovarian endometrioid cystadenoma 10.2 F3 SIRPA
15 urethral villous adenoma 10.2 AFP KLK3
16 sex differentiation disease 10.2 AFP KLK3
17 microcephaly 8, primary, autosomal recessive 10.2 F3 TTR
18 benign pericardial teratoma 10.1 AFP TNFRSF1B
19 vasculopathy, retinal, with cerebral leukodystrophy 10.1 SAMHD1 TNFRSF1B
20 prostatitis 10.1
21 urethritis 9.9
22 capillary hemangioma 9.9 AFP F3
23 aryepiglottic fold cancer 9.9 AFP F3
24 ureterocele 9.8
25 diabetes insipidus 9.8
26 posterior urethral valves 9.8
27 hydronephrosis 9.8
28 neurogenic bladder 9.8
29 sleep disorder 9.7 AFP TTR
30 hemolytic-uremic syndrome 9.7 AFP F3
31 hidradenoma 9.7 AFP F3
32 cystitis 9.6
33 uremia 9.6
34 vesicoureteral reflux 9.6
35 aneurysm 9.6
36 prostatic hypertrophy 9.6
37 ehlers-danlos syndrome 9.6
38 necrotic uveal melanoma 9.4 AFP F3
39 uterine corpus epithelioid leiomyoma 5.7 ACPP AFP CLN3 F3 HCCS KLK3

Comorbidity relations with Bladder Neck Obstruction via Phenotypic Disease Network (PDN): (show all 30)


Acute Cystitis Acute Kidney Failure
Balanoposthitis Bladder Disease
Chronic Kidney Failure Cystitis
Cystitis Cystica Epididymo-Orchitis
Gout Hydronephrosis
Kidney Disease Lipoma of Spermatic Cord
Nephrolithiasis, Type I Neurogenic Bladder
Peyronie's Disease Prostate Calculus
Prostate Cancer Prostate Carcinoma in Situ
Prostatic Hypertrophy Prostatitis
Prostatocystitis Radiation Cystitis
Spermatocele Ureterolithiasis
Urethral Calculus Urethral Stricture
Urethritis Urinary Bladder Cancer
Urinary Tract Obstruction Vesicoureteral Reflux

Graphical network of the top 20 diseases related to Bladder Neck Obstruction:



Diseases related to Bladder Neck Obstruction

Symptoms & Phenotypes for Bladder Neck Obstruction

MGI Mouse Phenotypes related to Bladder Neck Obstruction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 ACPP AFP CLN3 F3 PURA SIRPA

Drugs & Therapeutics for Bladder Neck Obstruction

Drugs for Bladder Neck Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fesoterodine Approved Phase 4 286930-02-7, 286930-03-8 6918558
2
Tamsulosin Approved, Investigational Phase 4,Phase 2,Phase 1 106133-20-4 129211
3
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
4
Doxazosin Approved Phase 4 74191-85-8 3157
5
Silodosin Approved Phase 4 160970-54-7
6
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
7
Baclofen Approved Phase 4 1134-47-0 2284
8
Ezogabine Approved Phase 4 150812-12-7 121892
9 Cholinergic Agents Phase 4,Phase 2,Phase 1
10 Cholinergic Antagonists Phase 4,Phase 2,Phase 1
11 Muscarinic Antagonists Phase 4,Phase 2,Phase 1
12 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
13 Adrenergic Agents Phase 4,Phase 2,Phase 1
14 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 2,Phase 1
15 Adrenergic alpha-Antagonists Phase 4,Phase 2,Phase 1
16 Adrenergic Antagonists Phase 4,Phase 2,Phase 1
17 Tolterodine tartrate Phase 4 124937-52-6
18 Antihypertensive Agents Phase 4
19 5-alpha Reductase Inhibitors Phase 4
20 Hormone Antagonists Phase 4
21 Hormones Phase 4
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
23 Steroid Synthesis Inhibitors Phase 4
24 Coagulants Phase 4
25 Hemostatics Phase 4
26 Anticonvulsants Phase 4
27 Mirabegron Approved Phase 2 223673-61-8
28
Tadalafil Approved, Investigational Phase 2 171596-29-5 110635
29 Solifenacin succinate Phase 2,Phase 1 242478-38-2
30 Adrenergic Agonists Phase 2
31 Adrenergic beta-3 Receptor Agonists Phase 2
32 Adrenergic beta-Agonists Phase 2
33 Phosphodiesterase 5 Inhibitors Phase 2
34 Phosphodiesterase Inhibitors Phase 2
35 Vasodilator Agents Phase 2
36 Anesthetics Phase 1, Phase 2
37 Fibrin Tissue Adhesive Phase 1
38
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
39 Central Nervous System Depressants
40 Calamus Nutraceutical

Interventional clinical trials:

(show all 46)

id Name Status NCT ID Phase Drugs
1 An Open Label Study to Measure Efficacy of Fesoterodine (Toviaz) Post Surgery for Benign Prostatic Hyperplasia Unknown status NCT00605319 Phase 4 Toviaz (Fesoterodine)
2 Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures Unknown status NCT01196572 Phase 4
3 Effect and Safety Of Detrol LA In Men With Overactive Bladder Symptoms With Or Without Bladder Outlet Obstruction Completed NCT00147654 Phase 4 Tolterodine ER 4 mg QD;Tamsulosin 0.4 mg QD
4 The Long Term Effects of Alfuzosin(Xatral XL) in Lower Urinary Tract Symptoms(LUTS)/BPH Patients Completed NCT00696761 Phase 4 alfuzosin;alfuzosin;alfuzosin;alfuzosin
5 Antimuscarinics as the First-line Treatment for Male With IPSS-V/S≤1 Completed NCT01661621 Phase 4 Detrusitol 4 mg QD;Doxazosin 4 mg QD
6 Evaluation of Symptom-specific Goal Achievement Completed NCT00836823 Phase 4 Alfuzosin
7 Efficacy and Safety of Silodosin on Voiding Dysfunction Associated With Neurogenic Bladder Completed NCT01228370 Phase 4 silodosin
8 Effect of Dutasteride on Bladder Wall Hypertrophy in Patients With Benign Prostatic Obstruction Completed NCT00827814 Phase 4 Dutasteride
9 Effect of TachoSil® on Incidence of Symptomatic and Radiographic Lymphoceles After Extended Pelvic Lymph Node Dissection in Prostate and Bladder Cancer. Completed NCT02001857 Phase 4 1 TachoSil hemostatic sponge (9,5 cm x 4,8 cm) placed on each side on the external iliac artery.
10 PVP Compared to TURP for the Treatment of Benign Hyperplasia of the Prostate Completed NCT00527371 Phase 4
11 Ejaculatory Sparing vs. Non-ejaculatory Sparing GreenLight Laser Photoselective Vaporization of the Prostate Recruiting NCT02749604 Phase 4
12 Dysfunctional Voiding and Lower Urinary Tract Symptoms With Baclofen Terminated NCT01003249 Phase 4 Baclofen;Placebo Comparator: Placebo
13 An Open Label Study to Evaluate the Effects of Ezogabine/Retigabine Added to Existing Anti-epileptic Drug(s) on Urinary Voiding Function in Subjects With Partial Onset Seizures Terminated NCT01607346 Phase 4 ezogabine/retigabine
14 Phase 3 Evaluation of Re-Injection of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH)(NX02-0022) Completed NCT01846793 Phase 3 NX-1207
15 Phase 3 Evaluation of Re-Injection of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH) Completed NCT01438775 Phase 3 NX-1207
16 Assessing Safety & Efficacy of MediTate Temporary Implant in Subjects With Benign Prostate Hyperplasia Completed NCT01436877 Phase 1, Phase 2
17 Solifenacin Succinate With Tamsulosin HCl in Males With Lower Urinary Tract Symptoms and Bladder Outlet Obstruction Completed NCT00507455 Phase 2 solifenacin succinate;tamsulosin hydrochloride;Placebo to solifenacin;Placebo to tamsulosin
18 A Study of Mirabegron (YM178) in Men With Lower Urinary Tract Symptoms (LUTS) and Bladder Outlet Obstruction (BOO) Completed NCT00410514 Phase 2 Mirabegron;Placebo
19 Prophylactic Urethral Stenting With Memokath After Prostate Implantation for Prostate Adenocarcinoma Completed NCT00252941 Phase 1, Phase 2
20 Effects of Tadalafil Once a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed NCT00386009 Phase 2 Tadalafil;Placebo
21 Urodynamic Effects of UK-369,003 in Men With Lower Urinary Tract Symptoms Completed NCT00408954 Phase 2 UK-369,003;UK-369,003
22 Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy Recruiting NCT02961114 Phase 1, Phase 2
23 Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture Enrolling by invitation NCT02869061 Phase 1, Phase 2
24 EC905 Pharmacokinetic Profile Study Completed NCT02634489 Phase 1 Tamsulosin HCl;Solifenacin Succinate;EC905
25 Liquid Buccal Mucosa Graft Urethroplasty Not yet recruiting NCT03061344 Phase 1
26 Diagnosis of Bladder Outlet Obstruction Using Dynamic Urine Vibration "Holter" in Comparison to Pressure Flow Study Unknown status NCT01388348
27 Comparison Between Invasive Pressure Flow Study and Non-invasive Penile Cuff Test Unknown status NCT02031653
28 The Effect of Daily Tamsulosin 0.2mg Administration on Renal Function in Patients With Benign Prostatic Hyperplasia Unknown status NCT02033798 Tamsulosin
29 The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group Unknown status NCT01762007
30 Functional Changes of Urogenital System After Holmium Laser Prostatectomy Unknown status NCT02033785
31 Non-Micturation Bladder Activity in Relation to Self-Consciousness During Filling Phase and Sensation Measurement During the Filling Phase Unknown status NCT00628615
32 The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction Completed NCT01482676
33 The Value of Multiple Urine Flow Rate Measurements in Male Benign Prostatic Hyperplasia (BPH) Subjects Completed NCT00710749
34 Impact of 80 W KTP Laser Vaporization Prostatectomy on Severity of Obstruction in Benign Prostatic Hyperplasia Completed NCT00908427
35 Sensitivity and Specificity of NGAL in an Emergency Room Population Completed NCT00786708
36 Anesthetic Management in Fetoscopic Surgery and Incidence of Complications Completed NCT02434926
37 Comparative Study Between Continuous Epidural Anesthesia And Continuous Spinal Anesthesia Using Wiley™ Spinal Catheter Completed NCT01845389
38 Urinary Markers for Unilateral Kidney Obstruction Completed NCT01979042
39 Ultrasound Guided Pudendal Block in Transurethral Prostatectomies Completed NCT01501279
40 Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods Recruiting NCT02193451
41 The Zenflow Spring System Feasibility and Safety Study Recruiting NCT02786290
42 Effects of Urinary Bladder Hypertrophy on Urge Urine Incontinence After Radical Prostatectomy Not yet recruiting NCT03061760
43 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO) Not yet recruiting NCT03281798
44 Laser Enucleation of Prostate (LEP) Versus Transurethral Resection of Prostate (TURP) Not yet recruiting NCT03062111
45 Bladder Outlet Obstruction Observation Using Dynamic Urine Vibration "Holter" Suspended NCT01779349
46 A Comparison of the Retropubic (TVT) With the Transobturator Sling Operation in the Treatment of Female Stress Urinary Incontinence or Stress Dominated Mixed Urinary Incontinence Terminated NCT00642109

Search NIH Clinical Center for Bladder Neck Obstruction

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: urinary bladder neck obstruction

Genetic Tests for Bladder Neck Obstruction

Anatomical Context for Bladder Neck Obstruction

MalaCards organs/tissues related to Bladder Neck Obstruction:

39
Prostate, Kidney, Testes, Lymph Node

Publications for Bladder Neck Obstruction

Articles related to Bladder Neck Obstruction:

(show top 50) (show all 164)
id Title Authors Year
1
The Long-term Effect of Superficial Bladder Neck Incision on Ejaculation and Incontinence in Boys with Primary and Secondary Bladder Neck Obstruction. ( 28752084 )
2017
2
Gait analysis of young male patients diagnosed with primary bladder neck obstruction. ( 28601565 )
2017
3
Primary bladder neck obstruction may be determined by postural imbalances. ( 27876119 )
2016
4
Application of Acoustic Radiation Force Impulse Imaging for Diagnosis of Female Bladder Neck Obstruction. ( 27162282 )
2016
5
Female primary bladder neck obstruction: role of videourodynamics and treatment options in a rare clinical entity. ( 27886351 )
2016
6
Controlled transurethral resection and incision of the bladder neck to treat female primary bladder neck obstruction: Description of a novel surgical procedure. ( 27037830 )
2016
7
Transurethral incision of the bladder neck in a woman with primary bladder neck obstruction after kidney transplantation. ( 25861513 )
2015
8
Use of transvaginal ultrasound in females with primary bladder neck obstruction. A preliminary study. ( 26150036 )
2015
9
Bladder neck incision for female bladder neck obstruction: long-term outcomes. ( 24680443 )
2014
10
Transurethral bladder neck incision in women with primary bladder neck obstruction. ( 24496715 )
2014
11
Thulium laser resection for bladder neck obstruction in women. ( 24988202 )
2014
12
Fetal therapy for the treatment of congenital bladder neck obstruction. ( 24934451 )
2014
13
Giant Urinary Bladder and Bilateral Giant Hydronephrosis due to Bladder Neck Obstruction: One Case Report and Literature Review. ( 22606637 )
2012
14
Urodynamic differences between dysfunctional voiding and primary bladder neck obstruction in women. ( 22748864 )
2012
15
Video-urodynamics study on female patients with bladder neck obstruction. ( 22613647 )
2012
16
Modified transurethral incision for primary bladder neck obstruction in women: a method to improve voiding function without urinary incontinence. ( 22310746 )
2012
17
Long-term safety, tolerability, and efficacy of I+1-adrenergic blocker in young men with primary bladder neck obstruction: results from a single centre in China. ( 22130960 )
2012
18
Effect of alfuzosin on female primary bladder neck obstruction. ( 18982236 )
2009
19
Transurethral incision of the bladder neck using KTP in the treatment of bladder neck obstruction in women. ( 19172099 )
2009
20
Modified transurethral incision of the bladder neck treating primary bladder neck obstruction in young men: a method to improve voiding function and to preserve antegrade ejaculation. ( 18204229 )
2008
21
Primary bladder neck obstruction in men, women, and children. ( 17880837 )
2007
22
Use of alpha1-blockers in female functional bladder neck obstruction. ( 15812214 )
2005
23
Diagnosis and treatment of primary bladder neck obstruction in men. ( 15978226 )
2005
24
Endoscopic incision for functional bladder neck obstruction in men: long-term outcome. ( 16040090 )
2005
25
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? ( 15963137 )
2005
26
Transurethral incision of bladder neck in treatment of bladder neck obstruction in women. ( 15708037 )
2005
27
Primary bladder neck obstruction in men and women. ( 16985885 )
2005
28
Treatment of primary bladder neck obstruction in women with transurethral resection of the bladder neck. ( 14767294 )
2004
29
Effect of cyclohexenonic long-chain fatty alcohol on rat overactive bladder induced by bladder neck obstruction. ( 15464073 )
2004
30
Bladder neck obstruction due to bilharzial cystitis as a cause of renal failure in Aden City. ( 14612029 )
2003
31
Unilateral transurethral incision for primary bladder neck obstruction: symptom relief and fertility preservation. ( 12783172 )
2003
32
Is endoscopic decompression of the neonatal extravesical upper pole ureterocele necessary for prevention of urinary tract infections or bladder neck obstruction? ( 11832766 )
2002
33
alpha1-Adrenergic blockers in young men with primary bladder neck obstruction. ( 12131312 )
2002
34
Endoscopic treatment of complete bladder neck obstruction by transurethral Seldinger technique. ( 11555013 )
2001
35
Bladder neck obstruction in the female. ( 11998456 )
2001
36
The effectiveness of terazosin, an alpha1-blocker, on bladder neck obstruction as assessed by urodynamic hydraulic energy. ( 10671877 )
2000
37
Management of functional bladder neck obstruction in women: use of alpha-blockers and pediatric resectoscope for bladder neck incision. ( 10569570 )
1999
38
Primary bladder neck obstruction: urodynamic findings and treatment results in 36 men. ( 8808886 )
1996
39
Laparoscopic cystomyotomy for bladder neck obstruction. ( 8845505 )
1995
40
Bladder neck obstruction caused by a large simple ureterocele in a young male. ( 7491202 )
1995
41
Functional bladder neck obstruction: a rare cause of renal failure. ( 7776419 )
1995
42
Functional bladder neck obstruction in males: a progressive disorder? ( 1478227 )
1992
43
Functional bladder neck obstruction in females--a revisit. ( 1687802 )
1991
44
Effects of prazosin in men with symptoms of bladder neck obstruction and a non-hyperplastic prostate. ( 2480639 )
1989
45
Bladder neck obstruction secondary to Brunn's cyst. ( 3336077 )
1988
46
Bladder neck obstruction in women. ( 3820385 )
1987
47
Origin of carcinomas causing bladder neck obstruction demonstrated by immunoperoxidase localisation of specific antigens. ( 3521781 )
1986
48
Functional bladder neck obstruction. Results of endoscopic bladder neck incision in 131 consecutive patients. ( 3971106 )
1985
49
Evaluation and treatment of dyssynergic bladder neck obstruction. Is synchronous pressure-flow cystourethrography necessary? ( 6485204 )
1984
50
Bladder neck obstruction in women: a real entity. ( 6539828 )
1984

Variations for Bladder Neck Obstruction

Expression for Bladder Neck Obstruction

Search GEO for disease gene expression data for Bladder Neck Obstruction.

Pathways for Bladder Neck Obstruction

Pathways related to Bladder Neck Obstruction according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 F3 KLK3 SIRPA
2 10.6 AFP TTR

GO Terms for Bladder Neck Obstruction

Cellular components related to Bladder Neck Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACPP AFP F3 KLK3 TAC1 TTR
2 extracellular region GO:0005576 9.17 ACPP AFP F3 KLK3 TAC1 TNFRSF1B

Biological processes related to Bladder Neck Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.46 ACPP SIRPA TNFRSF1B TTR
2 cellular protein metabolic process GO:0044267 9.43 AFP KLK3 TTR
3 associative learning GO:0008306 8.96 CLN3 TAC1
4 purine nucleobase metabolic process GO:0006144 8.62 ACPP TTR

Sources for Bladder Neck Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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