MCID: BLD047
MIFTS: 40

Bladder Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases, Nephrological diseases categories

Summaries for Bladder Squamous Cell Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards: Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to papilloma and transitional cell carcinoma. An important gene associated with Bladder Squamous Cell Carcinoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Glucocorticoid receptor regulatory network. The compounds hpvs and isotretinoin have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Bladder Squamous Cell Carcinoma

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Nephrological diseases


Aliases & Descriptions:

bladder squamous cell carcinoma 9 63
epidermoid carcinoma of the urinary bladder 9
squamous cell carcinoma of bladder 9
carcinoma squamous cell bladder 46


External Ids:

Disease Ontology9 DOID:3742
SNOMED-CT59 255111004
NCIt41 C4031

Related Diseases for Bladder Squamous Cell Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Bladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.2KRT10, KRT14, KRT5, CDKN2A
2transitional cell carcinoma10.4
3bladder diverticulum10.3
4urinary schistosomiasis10.2
5schistosomiasis10.2
6spina bifida10.2
7exstrophy of the bladder10.2
8prurigo nodularis10.2
9epidermolytic hyperkeratosis10.1KRT10
10epidermolysis bullosa simplex-mp10.1KRT5
11bladder carcinoma in situ10.0UPK2, CDKN2A
12bowen syndrome10.0KRT14, KRT10
13cervical intraepithelial neoplasia10.0CDKN2A, KRT10
14basal cell carcinoma10.0KRT10, S100A7
15cholesteatoma10.0KRT10, KRT14
16palmoplantar keratosis10.0KRT5, KRT10
17epidermolysis bullosa simplex, recessive 110.0KRT5, KRT14
18epidermolysis bullosa simplex, localized10.0KRT5, KRT14
19epidermolysis bullosa simplex, generalized10.0KRT14, KRT5
20epidermolysis bullosa simplex, dowling-meara type10.0KRT5, KRT14
21bladder carcinoma10.0CDKN2A, KRT10
22epidermolysis bullosa10.0KRT14, KRT5
23chordoma10.0KRT14, KRT5
24hypertrophic scars10.0KRT14, KRT5
25cervical squamous cell carcinoma10.0KRT14, CDKN2A, KRT10
26skin benign neoplasm10.0KRT14, KRT5
27bullous pemphigoid10.0KRT14, KRT5
28malignant mesothelioma10.0KRT5, CDKN2A
29ductal carcinoma in situ10.0KRT5, KRT14, S100A7
30esophageal cancer10.0CDKN2A, KRT14
31epidermolysis bullosa simplex10.0KRT5, KRT14, KRT10
32nonepidermolytic palmoplantar keratoderma10.0KRT10, KRT5, KRT14
33retinoblastoma10.0KRT14, KRT10, CDKN2A
34benign mesothelioma9.9CDKN2A, KRT14, KRT5
35oral cancer9.9CDKN2A, KRT14, KRT5
36lung small cell carcinoma9.9CDKN2A, KRT5, KRT14
37leukemia9.9CDKN2A, KRT14, KRT10, FABP12
38lung cancer9.9KRT5, CDKN2A, KRT14, UPK2
39cervical cancer9.9KRT14, KRT10, KRT5, CDKN2A
40skin disease9.9FABP5, KRT14, KRT10, S100A7, KRT5
41psoriasis9.9S100A7, KRT5, KRT10, KRT14, FABP5
42adenocarcinoma9.8KRT10, CDKN2A, SFN, KRT5, KRT14
43breast cancer9.8SFN, FABP5, CDKN2A, S100A7, KRT14, FABP12
44tongue squamous cell carcinoma9.7SFN, KRT5, KRT14, CDKN2A, KRT10, S100A7

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to bladder squamous cell carcinoma

Symptoms for Bladder Squamous Cell Carcinoma

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Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Bladder Squamous Cell Carcinoma

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Anatomical Context for Bladder Squamous Cell Carcinoma

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Animal Models for Bladder Squamous Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bladder Squamous Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9SFN, KRT14, KRT5, CDKN2A
2MP:00020068.9CDKN2A, KRT10, KRT14, SFN
3MP:00053828.7SFN, KRT14, KRT5, KRT10
4MP:00107717.9CDKN2A, KRT5, KRT14, KRT10, FABP5, SFN
5MP:00053787.7CDKN2A, FABP5, SFN, UPK2, KRT10, KRT14
6MP:00107687.4CDKN2A, KRT5, KRT14, KRT10, SFN, UPK2

Publications for Bladder Squamous Cell Carcinoma

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53PubMed
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Articles related to Bladder Squamous Cell Carcinoma:

(show all 14)
idTitleAuthorsYear
1
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
2
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. (22709884)
2012
3
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. (22684221)
2012
4
Enterovesical fistula caused by a bladder squamous cell carcinoma. (19725163)
2009
5
Bladder squamous cell carcinoma. (15143234)
2004
6
Bladder squamous cell carcinoma biomarkers derived from proteomics. (10892722)
2000
7
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. (10197442)
1999
8
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. (9685850)
1998
9
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
10
Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. (9307301)
1997
11
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. (8618345)
1996
12
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. (8749958)
1995
13
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. (1712997)
1991
14
Dramatic palliation for painful, fixed bladder squamous cell carcinoma with 5-fluorouracil infusion. (71361)
1977

Variations for Bladder Squamous Cell Carcinoma

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Expression for genes affiliated with Bladder Squamous Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for genes affiliated with Bladder Squamous Cell Carcinoma

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KRT5, KRT14
29.3KRT5, KRT14, SFN

Compounds for genes affiliated with Bladder Squamous Cell Carcinoma

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1hpvs4610.0CDKN2A, KRT14
2isotretinoin46 1211.0KRT14, KRT10
3calcipotriol46 62 30 1212.8KRT10, KRT14, KRT5
4hematoxylin469.8CDKN2A, KRT14, KRT10
5histidine469.4KRT10, KRT14, KRT5, CDKN2A
6proline469.4KRT5, KRT14, KRT10
7paraffin469.4KRT10, KRT14, KRT5, CDKN2A
8vitamin a46 25 1211.4KRT5, KRT14, FABP12
9progesterone46 30 62 25 1213.4KRT10, KRT14, KRT5, CDKN2A
10arginine469.3KRT10, KRT14, KRT5, CDKN2A
11threonine469.2KRT10, KRT14, KRT5, CDKN2A
12retinoid469.2KRT5, KRT14, KRT10, FABP12
13stearic acid46 25 1211.0FABP5, FABP12
14oleic acid46 30 25 1211.9FABP12, FABP5, CDKN2A
15estrogen468.9S100A7, KRT10, KRT14, KRT5, CDKN2A
16alanine468.8FABP12, KRT14, KRT5, CDKN2A
17cholesterol46 30 25 1211.5FABP12, FABP5, KRT14, CDKN2A
18lipid468.0FABP12, FABP5, KRT14, CDKN2A
19fatty acid467.3CDKN2A, SFN, FABP12, FABP5, S100A7, KRT10
20retinoic acid46 258.0FABP12, FABP5, LGALS7, S100A7, KRT10, KRT14
21calcium46 52 25 1210.0SFN, FABP12, FABP5, S100A7, KRT10, KRT14

GO Terms for genes affiliated with Bladder Squamous Cell Carcinoma

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17Gene Ontology
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Cellular components related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT10, KRT14, KRT5
2intermediate filamentGO:0058829.4KRT5, KRT14, KRT10
3cytosolGO:0058298.4CDKN2A, KRT5, KRT14, S100A7, SFN
4extracellular vesicular exosomeGO:0700627.8KRT5, KRT14, KRT10, UPK2, FABP5, SFN
5cytoplasmGO:0057377.0SFN, FABP5, S100A7, KRT10, KRT14, KRT5

Biological processes related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:0315819.8KRT14, KRT5
2cell junction assemblyGO:0343299.8KRT5, KRT14
3negative regulation of protein kinase activityGO:0064699.5CDKN2A, SFN
4epithelial cell differentiationGO:0308559.4KRT14, UPK2
5keratinocyte differentiationGO:0302169.2KRT10, S100A7, SFN
6epidermis developmentGO:0085448.6KRT5, KRT14, S100A7, FABP5

Products for genes affiliated with Bladder Squamous Cell Carcinoma

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  • Antibodies
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Sources for Bladder Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet