MCID: BLD047
MIFTS: 41

Bladder Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases, Nephrological diseases categories
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Summaries for Bladder Squamous Cell Carcinoma

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Disease Ontology:8 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards based summary: Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to papilloma and epidermolytic hyperkeratosis. An important gene associated with Bladder Squamous Cell Carcinoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Glucocorticoid receptor regulatory network. The compounds hpvs and isotretinoin have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Bladder Squamous Cell Carcinoma

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 39NCIt, 57SNOMED-CT
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Bladder Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Bladder Squamous Cell Carcinoma 8 62
Epidermoid Carcinoma of the Urinary Bladder 8 62
 
Squamous Cell Carcinoma of Bladder 8 62
Carcinoma Squamous Cell Bladder 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Nephrological diseases


External Ids:

Disease Ontology8 DOID:3742
SNOMED-CT57 255111004
NCIt39 C4031

Related Diseases for Bladder Squamous Cell Carcinoma

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Diseases related to Bladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma29.8KRT10, KRT14, KRT5, CDKN2A
2epidermolytic hyperkeratosis10.4KRT10
3transitional cell carcinoma10.4
4bladder diverticulum10.3
5epidermolysis bullosa simplex-mp10.3KRT5
6spina bifida10.2
7urinary schistosomiasis10.2
8schistosomiasis10.2
9exstrophy of the bladder10.2
10prurigo nodularis10.2
11bladder carcinoma in situ10.2UPK2, CDKN2A
12bowen syndrome10.1KRT14, KRT10
13cervical intraepithelial neoplasia10.1CDKN2A, KRT10
14basal cell carcinoma10.1KRT10, S100A7
15cholesteatoma10.1KRT10, KRT14
16palmoplantar keratosis10.0KRT5, KRT10
17epidermolysis bullosa simplex, recessive 110.0KRT5, KRT14
18epidermolysis bullosa simplex, localized10.0KRT5, KRT14
19epidermolysis bullosa simplex, generalized10.0KRT14, KRT5
20epidermolysis bullosa simplex, dowling-meara type10.0KRT5, KRT14
21bladder carcinoma10.0CDKN2A, KRT10
22epidermolysis bullosa10.0KRT14, KRT5
23chordoma10.0KRT14, KRT5
24hypertrophic scars9.9KRT14, KRT5
25cervical squamous cell carcinoma9.9KRT14, CDKN2A, KRT10
26skin benign neoplasm9.9KRT14, KRT5
27bullous pemphigoid9.9KRT14, KRT5
28malignant mesothelioma9.9KRT5, CDKN2A
29ductal carcinoma in situ9.9KRT5, KRT14, S100A7
30esophageal cancer9.8CDKN2A, KRT14
31epidermolysis bullosa simplex9.8KRT5, KRT14, KRT10
32nonepidermolytic palmoplantar keratoderma9.8KRT10, KRT5, KRT14
33retinoblastoma9.8KRT14, KRT10, CDKN2A
34oral cancer9.8CDKN2A, KRT14, KRT5
35lung small cell carcinoma9.7CDKN2A, KRT5, KRT14
36leukemia9.6CDKN2A, KRT14, KRT10, FABP12
37lung cancer9.6KRT5, CDKN2A, KRT14, UPK2
38cervical cancer9.6KRT14, KRT10, KRT5, CDKN2A
39skin disease9.5FABP5, KRT14, KRT10, S100A7, KRT5
40psoriasis9.5S100A7, KRT5, KRT10, KRT14, FABP5
41adenocarcinoma9.3KRT10, CDKN2A, SFN, KRT5, KRT14
42breast cancer9.1SFN, FABP5, CDKN2A, S100A7, KRT14, FABP12
43tongue squamous cell carcinoma8.9SFN, KRT5, KRT14, CDKN2A, KRT10, S100A7

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to bladder squamous cell carcinoma

Symptoms for Bladder Squamous Cell Carcinoma

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Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Bladder Squamous Cell Carcinoma

Search NIH Clinical Center for Bladder Squamous Cell Carcinoma

Genetic Tests for Bladder Squamous Cell Carcinoma

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Anatomical Context for Bladder Squamous Cell Carcinoma

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Animal Models for Bladder Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Bladder Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9CDKN2A, KRT5, KRT14, SFN
2MP:00020068.9CDKN2A, KRT14, KRT10, SFN
3MP:00053828.7SFN, KRT10, KRT14, KRT5
4MP:00107717.9CDKN2A, KRT5, KRT14, KRT10, FABP5, SFN
5MP:00053787.7SFN, FABP5, UPK2, KRT10, KRT14, CDKN2A
6MP:00107687.4SFN, FABP5, UPK2, KRT10, KRT14, KRT5

Publications for Bladder Squamous Cell Carcinoma

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Articles related to Bladder Squamous Cell Carcinoma:

(show all 15)
idTitleAuthorsYear
1
Vesicoenteric fistula due to bladder squamous cell carcinoma. (25045451)
2014
2
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
3
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. (22709884)
2012
4
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. (22684221)
2012
5
Enterovesical fistula caused by a bladder squamous cell carcinoma. (19725163)
2009
6
Bladder squamous cell carcinoma. (15143234)
2004
7
Bladder squamous cell carcinoma biomarkers derived from proteomics. (10892722)
2000
8
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. (10197442)
1999
9
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. (9685850)
1998
10
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
11
Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. (9307301)
1997
12
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. (8618345)
1996
13
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. (8749958)
1995
14
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. (1712997)
1991
15
Dramatic palliation for painful, fixed bladder squamous cell carcinoma with 5-fluorouracil infusion. (71361)
1977

Variations for Bladder Squamous Cell Carcinoma

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Expression for genes affiliated with Bladder Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Bladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for genes affiliated with Bladder Squamous Cell Carcinoma

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Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KRT5, KRT14
29.3KRT5, KRT14, SFN

Compounds for genes affiliated with Bladder Squamous Cell Carcinoma

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Compounds related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1hpvs4410.0CDKN2A, KRT14
2isotretinoin44 1111.0KRT14, KRT10
3calcipotriol44 61 28 1112.8KRT10, KRT14, KRT5
4hematoxylin449.8CDKN2A, KRT14, KRT10
5histidine449.4KRT10, KRT14, KRT5, CDKN2A
6proline449.4KRT5, KRT14, KRT10
7paraffin449.4KRT10, KRT14, KRT5, CDKN2A
8vitamin a44 24 1111.4KRT5, KRT14, FABP12
9progesterone44 28 61 24 1113.4KRT10, KRT14, KRT5, CDKN2A
10arginine449.3KRT10, KRT14, KRT5, CDKN2A
11threonine449.2KRT10, KRT14, KRT5, CDKN2A
12retinoid449.2KRT5, KRT14, KRT10, FABP12
13stearic acid44 24 1111.0FABP5, FABP12
14oleic acid44 28 24 1111.9FABP12, FABP5, CDKN2A
15estrogen448.9S100A7, KRT10, KRT14, KRT5, CDKN2A
16alanine448.8FABP12, KRT14, KRT5, CDKN2A
17cholesterol44 28 24 1111.5FABP12, FABP5, KRT14, CDKN2A
18lipid448.0FABP12, FABP5, KRT14, CDKN2A
19fatty acid447.3CDKN2A, SFN, FABP12, FABP5, S100A7, KRT10
20retinoic acid44 248.0FABP12, FABP5, LGALS7, S100A7, KRT10, KRT14
21calcium44 50 24 1110.0SFN, FABP12, FABP5, S100A7, KRT10, KRT14

GO Terms for genes affiliated with Bladder Squamous Cell Carcinoma

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Cellular components related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT10, KRT14, KRT5
2intermediate filamentGO:0058829.4KRT5, KRT14, KRT10
3cytosolGO:0058298.4CDKN2A, KRT5, KRT14, S100A7, SFN
4extracellular vesicular exosomeGO:0700627.8KRT5, KRT14, KRT10, UPK2, FABP5, SFN
5cytoplasmGO:0057377.0SFN, FABP5, S100A7, KRT10, KRT14, KRT5

Biological processes related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:0315819.8KRT14, KRT5
2cell junction assemblyGO:0343299.8KRT5, KRT14
3negative regulation of protein kinase activityGO:0064699.5CDKN2A, SFN
4epithelial cell differentiationGO:0308559.4KRT14, UPK2
5keratinocyte differentiationGO:0302169.2KRT10, S100A7, SFN
6epidermis developmentGO:0085448.6KRT5, KRT14, S100A7, FABP5

Products for genes affiliated with Bladder Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
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Sources for Bladder Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet