MCID: BLD047
MIFTS: 34

Bladder Squamous Cell Carcinoma malady

Skin diseases, Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Bladder Squamous Cell Carcinoma

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions for Bladder Squamous Cell Carcinoma:

Name: Bladder Squamous Cell Carcinoma 8 61
Epidermoid Carcinoma of the Urinary Bladder 8
 
Squamous Cell Carcinoma of Bladder 8
Carcinoma Squamous Cell Bladder 44


Classifications:



External Ids:

Disease Ontology8 DOID:3742
SNOMED-CT56 255111004
NCIt39 C4031

Summaries for Bladder Squamous Cell Carcinoma

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Disease Ontology:8 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards based summary: Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to papilloma and transitional cell carcinoma. An important gene associated with Bladder Squamous Cell Carcinoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Glucocorticoid receptor regulatory network. The compounds hpvs and isotretinoin have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and tumorigenesis.

Related Diseases for Bladder Squamous Cell Carcinoma

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Diseases related to Bladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma29.8CDKN2A, KRT5, KRT14, KRT10
2transitional cell carcinoma10.4
3epidermolytic hyperkeratosis10.4KRT10
4bladder diverticulum10.3
5epidermolysis bullosa simplex-mp10.3KRT5
6urinary schistosomiasis10.2
7schistosomiasis10.2
8exstrophy of the bladder10.2
9bowen syndrome10.1KRT14, KRT10
10cervical intraepithelial neoplasia10.1CDKN2A, KRT10
11basal cell carcinoma10.1KRT10, S100A7
12cholesteatoma10.1KRT14, KRT10
13palmoplantar keratosis10.0KRT5, KRT10
14epidermolysis bullosa simplex, recessive 110.0KRT14, KRT5
15epidermolysis bullosa simplex, dowling-meara type10.0KRT5, KRT14
16epidermolysis bullosa simplex, koebner type10.0KRT5, KRT14
17epidermolysis bullosa simplex, weber-cockayne type10.0KRT5, KRT14
18bladder cancer, somatic10.0CDKN2A, KRT10
19epidermolysis bullosa10.0KRT5, KRT14
20chordoma9.9KRT5, KRT14
21hypertrophic scars9.9KRT14, KRT5
22cervical squamous cell carcinoma9.9CDKN2A, KRT14, KRT10
23skin benign neoplasm9.9KRT5, KRT14
24bullous pemphigoid9.9KRT5, KRT14
25mesothelioma, somatic9.9CDKN2A, KRT5
26ductal carcinoma in situ9.9S100A7, KRT14, KRT5
27esophageal cancer9.8KRT14, CDKN2A
28epidermolysis bullosa simplex9.8KRT10, KRT14, KRT5
29palmoplantar keratoderma, nonepidermolytic9.8KRT10, KRT14, KRT5
30retinoblastoma9.8CDKN2A, KRT14, KRT10
31mesothelioma9.8KRT14, KRT5, CDKN2A
32oral cancer9.7KRT14, KRT5, CDKN2A
33small cell cancer of the lung, somatic9.7CDKN2A, KRT5, KRT14
34leukemia9.6FABP12, KRT10, KRT14, CDKN2A
35lung cancer9.6UPK2, KRT14, KRT5, CDKN2A
36cervical cancer, somatic9.6CDKN2A, KRT5, KRT14, KRT10
37skin disease9.5FABP5, S100A7, KRT10, KRT14, KRT5
38psoriasis9.5FABP5, S100A7, KRT10, KRT14, KRT5
39adenocarcinoma9.3SFN, KRT10, KRT14, KRT5, CDKN2A
40breast cancer9.1SFN, FABP12, FABP5, S100A7, KRT14, KRT5
41tongue squamous cell carcinoma8.9SFN, FABP5, LGALS7, S100A7, KRT10, KRT14

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to bladder squamous cell carcinoma

Symptoms for Bladder Squamous Cell Carcinoma

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Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Bladder Squamous Cell Carcinoma

Search NIH Clinical Center for Bladder Squamous Cell Carcinoma

Genetic Tests for Bladder Squamous Cell Carcinoma

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Anatomical Context for Bladder Squamous Cell Carcinoma

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Animal Models for Bladder Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Bladder Squamous Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9CDKN2A, KRT5, KRT14, SFN
2MP:00020068.9CDKN2A, KRT14, KRT10, SFN
3MP:00053828.7SFN, KRT10, KRT14, KRT5
4MP:00107717.9CDKN2A, KRT5, KRT14, KRT10, FABP5, SFN
5MP:00053787.7SFN, FABP5, UPK2, KRT10, KRT14, CDKN2A
6MP:00107687.4SFN, FABP5, UPK2, KRT10, KRT14, KRT5

Publications for Bladder Squamous Cell Carcinoma

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Articles related to Bladder Squamous Cell Carcinoma:

(show all 15)
idTitleAuthorsYear
1
Vesicoenteric fistula due to bladder squamous cell carcinoma. (25045451)
2014
2
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
3
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. (22709884)
2012
4
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. (22684221)
2012
5
Enterovesical fistula caused by a bladder squamous cell carcinoma. (19725163)
2009
6
Bladder squamous cell carcinoma. (15143234)
2004
7
Bladder squamous cell carcinoma biomarkers derived from proteomics. (10892722)
2000
8
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. (10197442)
1999
9
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. (9685850)
1998
10
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
11
Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. (9307301)
1997
12
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. (8618345)
1996
13
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. (8749958)
1995
14
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. (1712997)
1991
15
Dramatic palliation for painful, fixed bladder squamous cell carcinoma with 5-fluorouracil infusion. (71361)
1977

Variations for Bladder Squamous Cell Carcinoma

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Cosmic variations for Bladder Squamous Cell Carcinoma:

6
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110648TP53urinary tract,bladder,carcinoma,squamous cell carcinoma2

Expression for genes affiliated with Bladder Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for genes affiliated with Bladder Squamous Cell Carcinoma

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Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KRT5, KRT14
29.3KRT5, KRT14, SFN

Compounds for genes affiliated with Bladder Squamous Cell Carcinoma

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Compounds related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1hpvs4410.0KRT14, CDKN2A
2isotretinoin44 1111.0KRT14, KRT10
3calcipotriol44 60 28 1112.8KRT10, KRT14, KRT5
4hematoxylin449.8KRT14, KRT10, CDKN2A
5histidine449.4CDKN2A, KRT5, KRT14, KRT10
6proline449.4KRT5, KRT14, KRT10
7paraffin449.4KRT10, KRT14, KRT5, CDKN2A
8vitamin a44 24 1111.4FABP12, KRT5, KRT14
9progesterone44 28 60 24 1113.4KRT14, KRT10, CDKN2A, KRT5
10arginine449.3KRT10, KRT5, KRT14, CDKN2A
11threonine449.2KRT10, CDKN2A, KRT14, KRT5
12retinoid449.2KRT5, KRT14, KRT10, FABP12
13stearic acid44 24 1111.0FABP5, FABP12
14oleic acid44 28 24 1111.9CDKN2A, FABP5, FABP12
15estrogen448.9KRT14, S100A7, KRT10, KRT5, CDKN2A
16alanine448.8FABP12, KRT14, CDKN2A, KRT5
17cholesterol44 28 24 1111.5KRT14, FABP5, FABP12, CDKN2A
18lipid448.0CDKN2A, FABP12, FABP5, KRT14
19fatty acid447.3SFN, FABP12, FABP5, S100A7, KRT10, KRT5
20retinoic acid44 248.0KRT14, KRT10, S100A7, LGALS7, FABP5, FABP12
21calcium44 50 24 1110.0KRT5, KRT14, KRT10, S100A7, FABP5, FABP12

GO Terms for genes affiliated with Bladder Squamous Cell Carcinoma

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Cellular components related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.5KRT10, KRT14, KRT5
2intermediate filamentGO:00058829.4KRT5, KRT14, KRT10
3cytosolGO:00058298.4CDKN2A, KRT5, KRT14, S100A7, SFN
4extracellular vesicular exosomeGO:00700627.8KRT5, KRT14, KRT10, UPK2, FABP5, SFN
5cytoplasmGO:00057377.0SFN, FABP5, S100A7, KRT10, KRT14, KRT5

Biological processes related to Bladder Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:00315819.8KRT14, KRT5
2cell junction assemblyGO:00343299.8KRT5, KRT14
3negative regulation of protein kinase activityGO:00064699.5CDKN2A, SFN
4epithelial cell differentiationGO:00308559.4KRT14, UPK2
5keratinocyte differentiationGO:00302169.2KRT10, S100A7, SFN
6epidermis developmentGO:00085448.6KRT5, KRT14, S100A7, FABP5

Sources for Bladder Squamous Cell Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet