MCID: BLD047
MIFTS: 42

Bladder Squamous Cell Carcinoma malady

Skin diseases, Nephrological diseases, Cancer diseases categories

Summaries for Bladder Squamous Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A carcinoma of bladder that is manifested in squamous cells of the bladder.

MalaCards: Bladder Squamous Cell Carcinoma, also known as epidermoid carcinoma of the urinary bladder, is related to bladder carcinoma and squamous cell carcinoma. An important gene associated with Bladder Squamous Cell Carcinoma is KRT10 (keratin 10), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Type I hemidesmosome assembly. The compounds estrogen and hpvs have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and prostate, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Bladder Squamous Cell Carcinoma

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8Disease Ontology, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Nephrological diseases


Aliases & Descriptions:

bladder squamous cell carcinoma 8 60
epidermoid carcinoma of the urinary bladder 8
squamous cell carcinoma of bladder 8
carcinoma squamous cell bladder 44


External Ids:

Disease Ontology8 DOID:3742
SNOMED-CT56 255111004
NCIt39 C4031

Related Diseases for Bladder Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Bladder Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma31.1CDKN2A
2squamous cell carcinoma31.1SFN, S100A7, FABP5, CDKN2A, KRT5, KRT14
3transitional cell carcinoma30.5UPK2
4papilloma30.2CDKN2A, KRT5, KRT14, KRT10
5bladder transitional cell carcinoma10.3
6maxillary sinus squamous cell carcinoma10.2
7bladder diverticulum10.2
8bladder squamous papilloma10.2
9squamous cell papilloma10.2
10urinary schistosomiasis10.2
11schistosomiasis10.2
12spina bifida10.2
13dermatitis10.0S100A7
14keratosis10.0KRT10
15keratoderma10.0KRT14
16epidermolytic hyperkeratosis10.0KRT10
17lichen planus10.0KRT10
18endometrial carcinoma10.0CDKN2A
19epidermolysis bullosa simplex with mottled pigmentation10.0KRT5
20syringoma10.0KRT14
21congenital ichthyosiform erythroderma10.0KRT10
22laryngeal squamous cell carcinoma10.0CDKN2A
23benign mesothelioma10.0KRT5
24keratoacanthoma10.0KRT10
25cholesteatoma10.0KRT14, KRT10
26cervical intraepithelial neoplasia10.0CDKN2A, KRT10
27bowen syndrome10.0KRT10, KRT14
28epidermolysis bullosa10.0KRT14, KRT5
29epidermolysis bullosa simplex, localized10.0KRT5, KRT14
30epidermolysis bullosa simplex, generalized10.0KRT5, KRT14
31epidermolysis bullosa simplex, dowling-meara type10.0KRT5, KRT14
32palmoplantar keratosis10.0KRT5, KRT10
33chordoma10.0KRT14, KRT5
34hypertrophic scars10.0KRT14, KRT5
35bladder carcinoma in situ10.0UPK2, CDKN2A
36malignant mesothelioma10.0KRT5, CDKN2A
37ductal carcinoma in situ10.0KRT14, KRT5, S100A7
38skin benign neoplasm10.0KRT5, KRT14
39cervical squamous cell carcinoma10.0KRT10, KRT14, CDKN2A
40bullous pemphigoid10.0KRT14, KRT5
41nonepidermolytic palmoplantar keratoderma10.0KRT5, KRT14, KRT10
42epidermolysis bullosa simplex10.0KRT5, KRT14, KRT10
43oral cancer10.0CDKN2A, KRT5, KRT14
44retinoblastoma10.0CDKN2A, KRT14, KRT10
45colorectal cancer10.0KRT14, KRT5, CDKN2A
46lung small cell carcinoma10.0CDKN2A, KRT5, KRT14
47cervical cancer10.0KRT10, KRT14, KRT5, CDKN2A
48skin disease10.0S100A7, FABP5, KRT5, KRT14, KRT10
49psoriasis10.0S100A7, FABP5, KRT5, KRT14, KRT10
50lung cancer10.0UPK2, CDKN2A, KRT5, KRT14

Graphical network of the top 20 diseases related to Bladder Squamous Cell Carcinoma:



Diseases related to bladder squamous cell carcinoma

Clinical Features for Bladder Squamous Cell Carcinoma

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Drugs & Therapeutics for Bladder Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bladder Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Bladder Squamous Cell Carcinoma

Search NIH Clinical Center for Bladder Squamous Cell Carcinoma

Search CenterWatch for Bladder Squamous Cell Carcinoma

Genetic Tests for Bladder Squamous Cell Carcinoma

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Anatomical Context for Bladder Squamous Cell Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Bladder Squamous Cell Carcinoma:

32
Spinal cord, Kidney, Prostate, Lymph node

Animal Models for Bladder Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bladder Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0KRT10, KRT14, CDKN2A, SFN
2MP:00107717.9KRT10, KRT14, KRT5, CDKN2A, FABP5, SFN
3MP:00107687.2SFN, FABP5, UPK2, CDKN2A, KRT5, KRT14

Publications for Bladder Squamous Cell Carcinoma

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50PubMed
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Articles related to Bladder Squamous Cell Carcinoma:

(show all 44)
idTitleAuthorsYear
1
Intravesical mitomycin therapy for stage t1 and tis high-grade squamous cell carcinoma of the bladder. (24169496)
2014
2
Metastatic squamous cell carcinoma urinary bladder coexisting with tuberculosis in pelvic lymph nodes. (24296773)
2013
3
Squamous cell carcinoma of the bladder mimicking interstitial cystitis and voiding dysfunction. (24224109)
2013
4
Squamous cell carcinoma in exstrophy of the bladder. (23956833)
2013
5
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
6
Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report. (22709884)
2012
7
Squamous cell carcinoma associated with large bladder calculus. (22507514)
2012
8
CD10 and E-cad expression in urinary bladder urothelial and squamous cell carcinoma. (23339695)
2012
9
p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. (22684221)
2012
10
Expression of cell cycle-related molecular markers in patients treated with radical cystectomy for squamous cell carcinoma of the bladder. (21111452)
2011
11
Basaloid squamous cell carcinoma in the urinary bladder with small-cell carcinoma. (21402607)
2011
12
Squamous cell carcinoma arising in a mature cystic ovarian teratoma with bladder invasion: a case report. (21857863)
2011
13
Synchronous squamous cell carcinoma of the kidney, squamous cell carcinoma of the ureter, and sarcomatoid carcinoma of the urinary bladder: a case report. (19766408)
2010
14
Squamous cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 16 cases. (19454359)
2009
15
Urinary bladder carcinoma with triplicate differentiations into giant cell sarcomatoid carcinoma, squamous cell carcinoma, and papillary urothelial transitional cell carcinoma: a case report. (20062688)
2009
16
Enterovesical fistula caused by a bladder squamous cell carcinoma. (19725163)
2009
17
Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report. (19830128)
2009
18
Bcl-XL and Bcl-2 expression in bilharzial squamous cell carcinoma of the urinary bladder: which protein is prognostic? (18342927)
2008
19
Words of wisdom. Re: the role of squamous differentiation in patients with transitional cell carcinoma of the bladder treated with radical cystectomy. (18240413)
2008
20
Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (16217763)
2006
21
Squamous cell carcinoma of bladder producing granulocyte colony-stimulating factor (G-CSF): a case report]. (15773367)
2005
22
Muscle invasive schistosomal squamous cell carcinoma of the urinary bladder: frequency and prognostic significance of p53, BCL-2, HER2/neu, and proliferation (MIB-1). (14991535)
2004
23
Squamous cell carcinoma of the bladder presenting as vulvitis and cliteromegaly. (15581990)
2004
24
Bladder squamous cell carcinoma. (15143234)
2004
25
Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. (12954496)
2003
26
Prognostic value of p53 and MDM2 expression in bilharziasis-associated squamous cell carcinoma of the urinary bladder. (14756544)
2003
27
Problems in early diagnosis of bladder cancer in a spinal cord injury patient: report of a case of simultaneous production of granulocyte colony stimulating factor and parathyroid hormone-related protein by squamous cell carcinoma of urinary bladder. (12201902)
2002
28
Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. (11297248)
2001
29
Basaloid squamous cell carcinoma occurring in the urinary bladder. (10705407)
2000
30
Bladder squamous cell carcinoma biomarkers derived from proteomics. (10892722)
2000
31
Squamous cell carcinoma arising in a mature teratoma with metastasis to the urinary bladder. (10551730)
1999
32
Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. (10197442)
1999
33
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication. (9685850)
1998
34
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
35
Expression of bcl-2 and p53 oncoproteins in schistosomiasis-associated transitional and squamous cell carcinoma of urinary bladder. (9043502)
1997
36
Proteome profiling of bladder squamous cell carcinomas: identification of markers that define their degree of differentiation. (9307301)
1997
37
Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt. (8795591)
1996
38
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine. (8618345)
1996
39
Bladder squamous cell carcinoma with human papilloma virus type 6 [HPV 6]. (8749958)
1995
40
High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder. (7658499)
1995
41
Expression of squamous cell carcinoma-associated antigen in bladder cancer cells--a comparative study with the expression of proliferating cell nuclear antigen (PCNA)]. (7910645)
1994
42
UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma. (1712997)
1991
43
Squamous cell carcinoma of bladder diverticulum with initial symptoms produced by metastasis to maxillary sinus. (3145890)
1988
44
Dramatic palliation for painful, fixed bladder squamous cell carcinoma with 5-fluorouracil infusion. (71361)
1977

Genetic Variations for Bladder Squamous Cell Carcinoma

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Expression for genes affiliated with Bladder Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bladder Squamous Cell Carcinoma.

Pathways for genes affiliated with Bladder Squamous Cell Carcinoma

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12EMD Millipore, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KRT14, KRT5
29.8KRT14, KRT5
39.3KRT14, KRT5, SFN

Compounds for genes affiliated with Bladder Squamous Cell Carcinoma

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3S100A7
2hpvs4410.0CDKN2A, KRT14
3isotretinoin44 1110.9KRT10, KRT14
4calcipotriol44 59 28 1112.8KRT10, KRT14, KRT5
5hematoxylin449.7CDKN2A, KRT14, KRT10
6histidine449.4KRT10, KRT14, KRT5, CDKN2A
7paraffin449.4CDKN2A, KRT5, KRT14, KRT10
8progesterone44 59 28 11 2413.3KRT10, KRT14, KRT5, CDKN2A
9vitamin a44 11 2411.1FABP12, KRT5, KRT14
10arginine449.0CDKN2A, KRT5, KRT14, KRT10
11retinoid449.0FABP12, KRT5, KRT14, KRT10
12oleic acid44 28 11 2411.9CDKN2A, FABP12, FABP5
13threonine448.8CDKN2A, KRT5, KRT14, KRT10
14alanine448.6KRT14, KRT5, CDKN2A, FABP12
15cholesterol44 28 11 2411.4FABP5, FABP12, CDKN2A, KRT14
16fatty acid447.4KRT10, SFN, S100A7, FABP5, FABP12, CDKN2A
17retinoic acid44 248.1S100A7, FABP5, FABP12, CDKN2A, KRT5, KRT14
18calcium44 49 11 2410.1SFN, S100A7, FABP5, FABP12, CDKN2A, KRT5

GO Terms for genes affiliated with Bladder Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.4KRT10, KRT14, KRT5
2intermediate filamentGO:0058829.2KRT10, KRT14, KRT5
3cytoplasmGO:0057377.6S100A7, FABP5, CDKN2A, KRT5, KRT14, KRT10

Biological processes related to Bladder Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell differentiationGO:0308559.6KRT14, UPK2
2hemidesmosome assemblyGO:0315819.5KRT14, KRT5
3keratinocyte differentiationGO:0302169.1SFN, S100A7, KRT10
4epidermis developmentGO:0085448.8KRT14, KRT5, FABP5, S100A7

Products for genes affiliated with Bladder Squamous Cell Carcinoma

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  • Antibodies
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Sources for Bladder Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet