MCID: BLD048
MIFTS: 53

Bladder Transitional Cell Carcinoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Bladder Transitional Cell Carcinoma

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MalaCards: Bladder Transitional Cell Carcinoma, also known as transitional cell carcinoma of bladder, is related to transitional cell carcinoma and bladder carcinoma. An important gene associated with Bladder Transitional Cell Carcinoma is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Toll-like Receptor Pathway and HIF-1 signaling pathway. The compounds estrogen and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, prostate and lymph node, and related mouse phenotypes are no phenotypic analysis and cardiovascular system.

Aliases & Classifications for Bladder Transitional Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

bladder transitional cell carcinoma 8 10
transitional cell carcinoma of bladder 8 60
urinary bladder urothelial carcinoma 8
carcinoma transitional cell bladder 44


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Disease Ontology8 DOID:4006
NCIt39 C39851

Related Diseases for Bladder Transitional Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma31.9IFI27, FABP4, UPK1A, EGFR, CDKN1A, ERBB2
2bladder carcinoma31.9TP53, ERBB2, CDKN1A
3bladder carcinoma in situ30.6TP53, ERBB2, BLCAP, EGFR
4inverted papilloma30.3IFI27, KRT13
5papilloma30.3IFI27, CDKN1A, KRT13, TP53
6lung adenocarcinoma30.3EGFR, CDKN1A, HPGD, ERBB2, TP53
7adenocarcinoma30.3IFI27, EGFR, CDKN1A, MMP10, KRT13, ERBB2
8invasive bladder transitional cell carcinoma10.7
9in situ carcinoma10.4
10prostate transitional cell carcinoma10.3
11prostatitis10.3
12clear cell adenocarcinoma10.3
13signet ring cell adenocarcinoma10.3
14pleomorphic carcinoma10.3
15spindle cell carcinoma10.3
16bladder signet ring cell adenocarcinoma10.3
17large cell carcinoma10.3
18bladder clear cell adenocarcinoma10.3
19inverted transitional papilloma10.2
20papillary carcinoma10.2
21papillary transitional carcinoma10.2
22sarcomatoid transitional cell carcinoma10.2
23bladder urothelial papillary carcinoma10.2
24amyloidosis10.2
25bone carcinoma10.2
26prostate small cell carcinoma10.2
27small cell carcinoma10.2
28ovary transitional cell carcinoma10.2
29bladder adenocarcinoma10.2
30bladder disease10.2
31bladder diverticulum10.2
32bladder transitional cell papilloma10.2
33cervicitis10.2
34herpes simplex10.2
35lung small cell carcinoma10.2
36prostate adenocarcinoma10.2
37renal pelvis carcinoma10.2
38renal pelvis transitional cell carcinoma10.2
39transitional papilloma10.2
40gastrointestinal stromal tumor10.0IFI27
41cervical adenocarcinoma10.0CDKN1A, IFI27
42osteosarcoma10.0TP53, CDKN1A
43tongue cancer10.0CDKN1A
44leukoplakia10.0IFI27, KRT13
45esophageal cancer10.0TP53, EGFR
46laryngeal squamous cell carcinoma10.0IFI27, EGFR, CDKN1A, TP53
47uterine carcinosarcoma10.0ERBB2
48ductal carcinoma in situ10.0EGFR, ERBB2, TP53
49oral cavity cancer10.0TP53
50cervical intraepithelial neoplasia10.0IFI27

Graphical network of the top 20 diseases related to Bladder Transitional Cell Carcinoma:



Diseases related to bladder transitional cell carcinoma

Clinical Features for Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Bladder Transitional Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Bladder Transitional Cell Carcinoma

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Anatomical Context for Bladder Transitional Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Bladder Transitional Cell Carcinoma:

32
Endothelial, Prostate, Lymph node, Lung, Testes, Ovary, Kidney, Brain, Testis, Adipocyte, Heart, Cervix, Monocytes, Dentritic cells, Bone

Animal Models for Bladder Transitional Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bladder Transitional Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.3TP53, FGF3, CDKN1A, NR2F1, EGFR, HEPACAM
2MP:000538510.1TP53, FABP5, FABP4, EGFR, CDKN1A, HPGD
3MP:000537510.0FABP5, FABP4, EGFR, CDKN1A, TP53

Publications for Bladder Transitional Cell Carcinoma

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50PubMed
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Articles related to Bladder Transitional Cell Carcinoma:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Advanced transitional cell carcinoma of the bladder in a 16-year-old girl with Hinman syndrome. (22743257)
2012
3
Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder. (21396841)
2012
4
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. (23282659)
2012
5
Primary amyloidosis with high grade transitional cell carcinoma of bladder: a rare case report. (22842380)
2012
6
The apoptosis inhibitor survivin in transitional cell carcinoma of the urinary bladder]. (21695980)
2011
7
Palmar fasciitis and polyarthritis syndrome associated with transitional cell carcinoma of the bladder. (20638154)
2011
8
Endobronchial metastasis from transitional cell carcinoma of the urinary bladder. (23169086)
2011
9
Stauffer syndrome in transitional cell carcinoma of the bladder. (22155881)
2011
10
Intravesical mitomycin C combined with hyperthermia for patients with T1G3 transitional cell carcinoma of the bladder. (19395285)
2011
11
Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis. (21782798)
2011
12
Serum Th1 and Th2 cytokine balance in patients of superficial transitional cell carcinoma of bladder pre- and post-intravesical combination immunotherapy. (20105083)
2010
13
Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastases. (19919656)
2010
14
Reactive antibodies against bacillus Calmette-Guerin heat-shock protein-65 potentially predict the outcome of immunotherapy for high-grade transitional cell carcinoma of the bladder. (19957324)
2010
15
Initial results of bladder preserving approach by chemo-radiotherapy in patients with muscle invading transitional cell carcinoma. (21057568)
2009
16
Transitional cell carcinoma urinary bladder manifesting as second malignancy following radiotherapy for carcinoma cervix. (19282572)
2009
17
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT). (19849847)
2009
18
Independent predictors of metachronous bladder transitional cell carcinoma (TCC) after nephroureterectomy for TCC of the upper urinary tract. (18699961)
2008
19
Molecular markers in transitional cell carcinoma of the bladder: New insights into mechanisms and prognosis. (19468362)
2008
20
Follow-up of nonmuscle invasive transitional cell carcinoma of the bladder: how and how often? (18670275)
2008
21
Expression of CD44s and CD44v6 in transitional cell carcinomas of the urinary bladder: comparison with tumour grade, proliferative activity and p53 immunoreactivity of tumour cells. (18092951)
2007
22
Significance of muscularis mucosae in metastasis involvement of urinary bladder transitional cell carcinoma. (17100383)
2006
23
Qualitative and quantitative analysis of angiogenetic factors in transitional cell bladder carcinoma: relationship with clinical course at 10 years follow-up. (15944797)
2005
24
Does human papillomavirus play a role in the development of bladder transitional cell carcinoma? A comparison of PCR and immunohistochemical analysis. (15677544)
2005
25
The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder. (15886698)
2005
26
Expression of lung resistance-related protein gene in transitional cell carcinoma of the bladder]. (15771821)
2005
27
Management of clinical T1 bladder transitional cell carcinoma by radical cystectomy. (15283885)
2004
28
Quantitative microscopy of human DNA topoisomerase II-alpha expression in transitional cell carcinoma of the bladder. (15457669)
2004
29
HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. (14520464)
2003
30
Evaluation of chromosome 8 and 11 aneuploidies in washings and biopsy materials of bladder transitional cell carcinoma. (12660029)
2003
31
Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. (12913755)
2003
32
P53 mutation predicts intravesical adriamycin instillation failure in superficial transitional cell carcinoma of bladder. (12926093)
2003
33
Monitoring gene expression profile changes in bladder transitional cell carcinoma using cDNA microarray. (12644218)
2002
34
Loss of heterozygosity of tumor suppressor genes at chromosome 3p in transitional cell carcinoma of urinary bladder]. (12509916)
2002
35
Qualitative and quantitative detection of urinary human complement factor H-related protein (BTA stat and BTA TRAK) and fragments of cytokeratins 8, 18 (UBC rapid and UBC IRMA) as markers for transitional cell carcinoma of the bladder. (11999463)
2002
36
High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma. (12036448)
2002
37
Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival. (11299807)
2001
38
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder. (11342973)
2001
39
p53 protein expression and proliferative activity in imprints of superficial transitional cell carcinoma of the bladder. (10872039)
2000
40
Prognostic significance of p53 protein accumulation in stage pT1 transitional cell carcinoma of the bladder. (10668937)
1999
41
Production of trophoblastic hormones by transitional cell carcinoma of the bladder: association to tumor stage and grade. (9563788)
1998
42
The expression of p53 and bcl-2 in superficial bladder transitional cell carcinoma and its role in the outcome of postoperative intravesical chemotherapy. (9891547)
1998
43
Quantitative studies of the kinetics of 5-aminolaevulinic acid-induced fluorescence in bladder transitional cell carcinoma. (9792160)
1998
44
Does prostate transitional cell carcinoma preclude orthotopic bladder reconstruction after radical cystoprostatectomy for bladder cancer? (9366327)
1997
45
Expression of bcl-2 and p53 oncoproteins in schistosomiasis-associated transitional and squamous cell carcinoma of urinary bladder. (9043502)
1997
46
Expression of PCNA/cyclin, p53, C-erbB-2 versus histological grade in transitional cell carcinoma of urinary bladder]. (7785554)
1995
47
Distribution of S-100 protein-positive dendritic cells inside the cancer nest and expression of HLA-DR antigen and blood group antigen on the cancer cell in transitional cell carcinoma of the urinary bladder--in relation to tumor progression and prognosis]. (8170082)
1994
48
Transitional cell carcinoma of the renal pelvis with choriocarcinomatous differentiation. Immunohistochemical and immunoelectron microscopic assessment of human chorionic gonadotropin production by transitional cell carcinoma of the urinary bladder. (8448745)
1993
49
Intravesical therapy of superficial bladder transitional cell carcinoma with tumor necrosis factor-alpha: preliminary report of a phase I-II study. (1478224)
1992
50
Epidermal nevus syndrome: report of association with transitional cell carcinoma of the bladder. (3562359)
1986

Genetic Variations for Bladder Transitional Cell Carcinoma

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Expression for genes affiliated with Bladder Transitional Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Transitional Cell Carcinoma

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Pathways for genes affiliated with Bladder Transitional Cell Carcinoma

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59Tocris Bioscience, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome, 55SinoBiological, 49PharmGKB
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Pathways related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4TP53, ERBB2
210.4ERBB2, EGFR
3
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10.4ELK1, TP53
4
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10.4ELK1, EGFR
510.4TP53, CDKN1A, EGFR
6
Transcription Androgen Receptor nuclear signaling
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10.4EGFR, CDKN1A, ERBB2
710.4EGFR, CDKN1A, ERBB2
8
Hide members
10.4CDKN1A, TP53, ELK1
9
Development TGF-beta receptor signaling
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10.4ELK1, ERBB2, CDKN1A
10
Apoptosis and survival Apoptotic TNF-family pathways
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10.4CDKN1A, BIRC7, TP53
11
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10.4TP53, ERBB2, CDKN1A, EGFR
1210.4TP53, ERBB2, CDKN1A, EGFR
1310.4TP53, ERBB2, CDKN1A, EGFR
14
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10.4EGFR, CDKN1A, ERBB2, TP53
1510.4EGFR, CDKN1A, ERBB2, TP53
16
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10.4ERBB2, FGF3, CDKN1A, EGFR
17
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10.4EGFR, CDKN1A, FGF3, ERBB2
18
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10.4EGFR, CDKN1A, FGF3, ERBB2
19
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10.3ELK1, TP53, ERBB2, EGFR
2010.3EGFR, ERBB2, TP53, ELK1
21
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10.3EGFR, CDKN1A, FGF3, ERBB2, TP53
22
Hide members
10.3EGFR, CDKN1A, ERBB2, TP53, ELK1
23
Hide members
10.3EGFR, CDKN1A, ERBB2, TP53, ELK1
24
Hide members
10.3EGFR, FGF3, ERBB2, TP53, ELK1
2510.3ELK1, TP53, ERBB2, FGF3, CDKN1A, EGFR
2610.3EGFR, CDKN1A, FGF3, BIRC7, ERBB2, TP53
27
Hide members
10.3EGFR, CDKN1A, FGF3, MMP10, ERBB2, TP53

Compounds for genes affiliated with Bladder Transitional Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9NR2F1
2hrgbeta14410.8ERBB2, CDKN1A, EGFR
3taxane4410.8CDKN1A, EGFR, TP53, ERBB2
4suberoylanilide hydroxamic acid4410.8CDKN1A, EGFR, ERBB2, TP53
5oxaliplatin44 49 1112.8EGFR, TP53, CDKN1A, ERBB2
6flavopiridol44 1111.8ERBB2, EGFR, CDKN1A, TP53
7bortezomib44 1111.8ERBB2, CDKN1A, TP53, EGFR
8irinotecan44 49 1112.8ERBB2, TP53, CDKN1A, EGFR
9temozolomide44 1111.8EGFR, CDKN1A, TP53
10thymidylate4410.8EGFR, TP53, ERBB2, CDKN1A, IFI27
11gefitinib44 49 1112.7ERBB2, CDKN1A, EGFR, IFI27
12geldanamycin44 49 59 1113.7TP53, EGFR, CDKN1A, ERBB2
13gemcitabine44 49 1112.7ERBB2, CDKN1A, TP53, EGFR
14adpribose4410.7TP53, IFI27, CDKN1A, EGFR
15optimax4410.7IFI27, CDKN1A
16p000484410.7IFI27, CDKN1A
175fluorouracil4410.7CDKN1A, BIRC7, ERBB2, TP53, EGFR
18docetaxel44 49 59 1113.7EGFR, CDKN1A, ERBB2, TP53
19doxorubicin44 49 1112.7BIRC7, CDKN1A, TP53, EGFR, IFI27, ERBB2
20retinoid4410.7EGFR, TP53, CDKN1A, FABP12, FABP4, IFI27
21resveratrol44 59 11 2413.7ERBB2, CDKN1A, IFI27, TP53
22Afatinib1110.7EGFR, ERBB2
23paraffin4410.7IFI27, CDKN1A, EGFR, KRT13, ERBB2, TP53
24n acetylcysteine4410.7ERBB2, EGFR, TP53, IFI27, CDKN1A
25tamoxifen44 49 28 1113.7TP53, CDKN1A, EGFR, IFI27, ERBB2
26progesterone44 59 28 11 2414.7IFI27, EGFR, NR2F1, CDKN1A, ERBB2, HPGD
27paclitaxel44 49 1112.7TP53, ERBB2, CDKN1A, EGFR, IFI27
28indole-3-carbinol4410.7IFI27, CDKN1A, TP53
29cisplatin44 49 59 1113.7TP53, CDKN1A, EGFR, IFI27, BIRC7, ERBB2
30troglitazone44 28 59 1113.7KRT13, IFI27, FABP4, CDKN1A
31steroid4410.7ERBB2, FGF3, HPGD, FABP4, FABP5, IFI27
32vitamin d4410.7IFI27, CDKN1A, HPGD, KRT13, ERBB2
33mg 13244 5911.6IFI27, EGFR, CDKN1A, TP53
34vegf4410.6EGFR, IFI27, CDKN1A, FGF3, MMP10, ERBB2
35sulindac44 1111.6IFI27, TP53, CDKN1A
36batimastat44 59 1112.6EGFR, MMP10, ERBB2
37ly2940024410.6EGFR, CDKN1A, TP53, ERBB2, IFI27
38topotecan44 1111.6TP53, EGFR, ERBB2
39oligonucleotide4410.6NR2F1, CDKN1A, FGF3, MMP10, TP53, MZF1
40ag 1478 hydrochloride5910.6EGFR, ERBB2
41curcumin4410.6EGFR, CDKN1A, ERBB2, TP53
42ag 4905910.6EGFR, ERBB2
43jnj 28871063 hydrochloride5910.5ERBB2, EGFR
44retinoic acid44 2411.5ELK1, IFI27, FABP5, FABP4, FABP12, EGFR
45iressa5910.5EGFR, ERBB2
46pd1587804410.4EGFR, ERBB2
47pertuzumab44 49 1112.4ERBB2, EGFR
48serine4410.4ELK1, TP53, ERBB2, BIRC7, MMP10, HPGD
49n-(4-hydroxyphenyl)retinamide4410.3TP53, ERBB2, CDKN1A
50roscovitine4410.1TP53, CDKN1A, IFI27

GO Terms for genes affiliated with Bladder Transitional Cell Carcinoma

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16Gene Ontology
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Biological processes related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801510.5EGFR, CDKN1A, FGF3, ERBB2
2neurotrophin TRK receptor signaling pathwayGO:04801110.5ELK1, ERBB2, FGF3, CDKN1A, EGFR
3fibroblast growth factor receptor signaling pathwayGO:00854310.4ERBB2, FGF3, CDKN1A, EGFR
4Fc-epsilon receptor signaling pathwayGO:03809510.4EGFR, CDKN1A, FGF3, ERBB2
5innate immune responseGO:04508710.3ELK1, ERBB2, FGF3, CDKN1A, EGFR
6epidermal growth factor receptor signaling pathwayGO:00717310.3ERBB2, FGF3, CDKN1A, EGFR
7mitotic cell cycle arrestGO:07185010.1CDKN1A, TP53

Molecular functions related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.4ERBB2, EGFR
2epidermal growth factor-activated receptor activityGO:00500610.1ERBB2, EGFR

Products for genes affiliated with Bladder Transitional Cell Carcinoma

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  • Antibodies
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Sources for Bladder Transitional Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet