MCID: BLD048
MIFTS: 53

Bladder Transitional Cell Carcinoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Bladder Transitional Cell Carcinoma

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MalaCards: Bladder Transitional Cell Carcinoma, also known as transitional cell carcinoma of bladder, is related to transitional cell carcinoma and bladder carcinoma. An important gene associated with Bladder Transitional Cell Carcinoma is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Toll-like Receptor Pathway and HIF-1 signaling pathway. The compounds estrogen and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, prostate and lymph node, and related mouse phenotypes are no phenotypic analysis and cardiovascular system.

Aliases & Classifications for Bladder Transitional Cell Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

bladder transitional cell carcinoma 8 10
transitional cell carcinoma of bladder 8 60
urinary bladder urothelial carcinoma 8
carcinoma transitional cell bladder 44


External Ids:

Disease Ontology8 DOID:4006
NCIt39 C39851

Related Diseases for Bladder Transitional Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma31.9IFI27, FABP4, UPK1A, EGFR, CDKN1A, ERBB2
2bladder carcinoma31.9TP53, ERBB2, CDKN1A
3bladder carcinoma in situ30.6TP53, ERBB2, BLCAP, EGFR
4inverted papilloma30.3IFI27, KRT13
5papilloma30.3IFI27, CDKN1A, KRT13, TP53
6lung adenocarcinoma30.3EGFR, CDKN1A, HPGD, ERBB2, TP53
7adenocarcinoma30.3IFI27, EGFR, CDKN1A, MMP10, KRT13, ERBB2
8invasive bladder transitional cell carcinoma10.7
9in situ carcinoma10.4
10prostate transitional cell carcinoma10.3
11prostatitis10.3
12clear cell adenocarcinoma10.3
13signet ring cell adenocarcinoma10.3
14pleomorphic carcinoma10.3
15spindle cell carcinoma10.3
16bladder signet ring cell adenocarcinoma10.3
17large cell carcinoma10.3
18bladder clear cell adenocarcinoma10.3
19inverted transitional papilloma10.2
20papillary carcinoma10.2
21papillary transitional carcinoma10.2
22sarcomatoid transitional cell carcinoma10.2
23bladder urothelial papillary carcinoma10.2
24amyloidosis10.2
25bone carcinoma10.2
26prostate small cell carcinoma10.2
27small cell carcinoma10.2
28ovary transitional cell carcinoma10.2
29bladder adenocarcinoma10.2
30bladder disease10.2
31bladder diverticulum10.2
32bladder transitional cell papilloma10.2
33cervicitis10.2
34herpes simplex10.2
35lung small cell carcinoma10.2
36prostate adenocarcinoma10.2
37renal pelvis carcinoma10.2
38renal pelvis transitional cell carcinoma10.2
39transitional papilloma10.2
40gastrointestinal stromal tumor10.0IFI27
41cervical adenocarcinoma10.0CDKN1A, IFI27
42osteosarcoma10.0TP53, CDKN1A
43tongue cancer10.0CDKN1A
44leukoplakia10.0IFI27, KRT13
45esophageal cancer10.0TP53, EGFR
46laryngeal squamous cell carcinoma10.0IFI27, EGFR, CDKN1A, TP53
47uterine carcinosarcoma10.0ERBB2
48ductal carcinoma in situ10.0EGFR, ERBB2, TP53
49oral cavity cancer10.0TP53
50cervical intraepithelial neoplasia10.0IFI27

Graphical network of the top 20 diseases related to Bladder Transitional Cell Carcinoma:



Diseases related to bladder transitional cell carcinoma

Clinical Features for Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Bladder Transitional Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Bladder Transitional Cell Carcinoma

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Anatomical Context for Bladder Transitional Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Bladder Transitional Cell Carcinoma:

32
Endothelial, Prostate, Lymph node, Lung, Testes, Ovary, Kidney, Brain, Testis, Adipocyte, Heart, Cervix, Monocytes, Dentritic cells, Bone

Animal Models for Bladder Transitional Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bladder Transitional Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.3TP53, FGF3, CDKN1A, NR2F1, EGFR, HEPACAM
2MP:000538510.1TP53, FABP5, FABP4, EGFR, CDKN1A, HPGD
3MP:000537510.0FABP5, FABP4, EGFR, CDKN1A, TP53

Publications for Bladder Transitional Cell Carcinoma

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50PubMed
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Articles related to Bladder Transitional Cell Carcinoma:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma. (23613251)
2013
2
Non-muscle invasive transitional cell carcinoma of the distal ureter and bladder with lung metastasis: A case report and literature review. (23500737)
2013
3
Mutations of fibroblast growth factor receptor 3 gene (FGFR3) in transitional cell carcinoma of urinary bladder in Thai patients [Revision-2a]. (23991606)
2013
4
Redox- and expression-proteomic analysis of plasma biomarkers in bladder transitional cell carcinoma. (23090237)
2012
5
Urinary schistosomiasis with simultaneous bladder squamous cell carcinoma and transitional cell carcinoma. (23109968)
2012
6
Rare association of anti-hu antibody positive paraneoplastic neurological syndrome and transitional cell bladder carcinoma. (23320243)
2012
7
Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam. (22408147)
2012
8
The expression of pigment epithelium-derived factor in bladder transitional cell carcinoma. (23110012)
2012
9
Hedgehog pathway activation in human transitional cell carcinoma of the bladder. (22361633)
2012
10
Metastasis from transitional cell carcinoma of urinary bladder as cystic pulmonary lesion. (22263064)
2011
11
Clinical significance of T-cadherin tissue expression in patients with bladder transitional cell carcinoma. (21252481)
2011
12
Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder. (21637416)
2010
13
Gli2 expression and human bladder transitional carcinoma cell invasiveness. (20488474)
2010
14
Hypofractionated whole-brain radiotherapy for multiple brain metastases from transitional cell carcinoma of the bladder. (20171794)
2010
15
Retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision for native upper tract transitional cell carcinoma ipsilateral to a transplanted kidney. (20430425)
2010
16
Efficacy of bladder-preserving therapy for patients with t3b, t4a, and t4b transitional cell carcinoma of the bladder. (20733957)
2010
17
Analysis of the relationship between expression of caveolin-1 and prognosis in bladder transitional cell carcinoma]. (20819483)
2010
18
High-grade transitional cell carcinoma and melanosis of urinary bladder: case report and review of the literature. (19056107)
2009
19
A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells. (19115207)
2009
20
Management of early-invasive high-grade transitional cell carcinoma of the bladder. (18923363)
2008
21
Management of the distal ureter and bladder cuff during nephroureterectomy for transitional cell carcinoma. (18811506)
2008
22
Retroperitoneal nephroureterectomy with excision of cuff of the bladder for upper urinary tract transitional cell carcinoma: comparison of laparoscopic and open surgery with long-term follow-up. (18431579)
2008
23
Words of wisdom. Re: cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era. (18240412)
2008
24
Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. (15989448)
2005
25
Comparison of the nuclear matrix protein 22 with voided urine cytology in the diagnosis of transitional cell carcinoma of the bladder. (14685796)
2004
26
Restoration of bone morphogenetic protein receptor type II expression leads to a decreased rate of tumor growth in bladder transitional cell carcinoma cell line TSU-Pr1. (15492256)
2004
27
Altered mRNA expression of the Rb and p16 tumor suppressor genes and of CDK4 in transitional cell carcinomas of the urinary bladder associated with tumor progression. (15161057)
2004
28
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. (15117815)
2004
29
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. (14634451)
2003
30
Laparoscopic port-site metastases from bladder transitional cell carcinoma. (19125474)
2003
31
p53 mutation and bcl-2 expression in transitional cell carcinoma of the urinary bladder. (11310375)
2001
32
The role of different biomarkers (DNA, PCNA, apoptosis and karyotype) in prognostic evaluation of superficial transitional cell bladder carcinoma. (11396199)
2001
33
Chromosome 9 aberrations by fluorescence in situ hybridisation in bladder transitional cell carcinoma. (11506956)
2001
34
Prospective evaluation of Ki-67 labeling in predicting the recurrence and progression of superficial bladder transitional cell carcinoma. (11528194)
2001
35
Transitional cell carcinomas of the ovary and bladder are immunophenotypically different. (10792484)
2000
36
Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. (10873095)
2000
37
galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas. (9988230)
1999
38
Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder. (9817940)
1998
39
Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. (9515818)
1998
40
Results at 43 months' follow-up of a double-blind, randomized, prospective clinical trial using intravesical interferon alpha-2b in the prophylaxis of stage pT1 transitional cell carcinoma of the bladder. (9037279)
1997
41
Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder. (8859190)
1996
42
Intravesical suramin: a novel agent for the treatment of superficial transitional-cell carcinoma of the bladder. (8738403)
1996
43
Glutathione S-transferase and multidrug-resistant phenotype in transitional cell carcinoma of the bladder. (8791059)
1996
44
Treatment of transitional cell carcinoma of the bladder with intravesical interleukin-2: a pilot study. (7804362)
1993
45
Behavior of epithelial differentiation antigens (carcinoembryonic antigen, epithelial membrane antigen, keratin and cytokeratin) in transitional cell carcinomas of the bladder. (1376008)
1992
46
Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder. (1673627)
1991
47
Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder. (1712624)
1991
48
HLA antigens and transitional cell carcinoma of the bladder. (2330661)
1990
49
Nephrogenic adenoma in patients with transitional cell carcinoma of the bladder receiving intravesical thiotepa. (3121867)
1988
50
Galactosyl transferase activity in rat bladder transitional cell carcinoma lines and in exfoliated cells in urine during carcinogenesis and reversible hyperplasia. (6778604)
1980

Genetic Variations for Bladder Transitional Cell Carcinoma

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Expression for genes affiliated with Bladder Transitional Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bladder Transitional Cell Carcinoma

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Pathways for genes affiliated with Bladder Transitional Cell Carcinoma

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59Tocris Bioscience, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome, 55SinoBiological, 49PharmGKB
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Pathways related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4TP53, ERBB2
210.4ERBB2, EGFR
3
Hide members
10.4ELK1, TP53
4
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10.4ELK1, EGFR
510.4TP53, CDKN1A, EGFR
6
Transcription Androgen Receptor nuclear signaling
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10.4EGFR, CDKN1A, ERBB2
710.4EGFR, CDKN1A, ERBB2
8
Hide members
10.4CDKN1A, TP53, ELK1
9
Development TGF-beta receptor signaling
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10.4ELK1, ERBB2, CDKN1A
10
Apoptosis and survival Apoptotic TNF-family pathways
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10.4CDKN1A, BIRC7, TP53
11
Hide members
10.4TP53, ERBB2, CDKN1A, EGFR
1210.4TP53, ERBB2, CDKN1A, EGFR
1310.4TP53, ERBB2, CDKN1A, EGFR
14
Hide members
10.4EGFR, CDKN1A, ERBB2, TP53
1510.4EGFR, CDKN1A, ERBB2, TP53
16
Hide members
10.4ERBB2, FGF3, CDKN1A, EGFR
17
Hide members
10.4EGFR, CDKN1A, FGF3, ERBB2
18
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10.4EGFR, CDKN1A, FGF3, ERBB2
19
Hide members
10.3ELK1, TP53, ERBB2, EGFR
2010.3EGFR, ERBB2, TP53, ELK1
21
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10.3EGFR, CDKN1A, FGF3, ERBB2, TP53
22
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10.3EGFR, CDKN1A, ERBB2, TP53, ELK1
23
Hide members
10.3EGFR, CDKN1A, ERBB2, TP53, ELK1
24
Hide members
10.3EGFR, FGF3, ERBB2, TP53, ELK1
2510.3ELK1, TP53, ERBB2, FGF3, CDKN1A, EGFR
2610.3EGFR, CDKN1A, FGF3, BIRC7, ERBB2, TP53
27
Hide members
10.3EGFR, CDKN1A, FGF3, MMP10, ERBB2, TP53

Compounds for genes affiliated with Bladder Transitional Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9NR2F1
2hrgbeta14410.8ERBB2, CDKN1A, EGFR
3taxane4410.8CDKN1A, EGFR, TP53, ERBB2
4suberoylanilide hydroxamic acid4410.8CDKN1A, EGFR, ERBB2, TP53
5oxaliplatin44 49 1112.8EGFR, TP53, CDKN1A, ERBB2
6flavopiridol44 1111.8ERBB2, EGFR, CDKN1A, TP53
7bortezomib44 1111.8ERBB2, CDKN1A, TP53, EGFR
8irinotecan44 49 1112.8ERBB2, TP53, CDKN1A, EGFR
9temozolomide44 1111.8EGFR, CDKN1A, TP53
10thymidylate4410.8EGFR, TP53, ERBB2, CDKN1A, IFI27
11gefitinib44 49 1112.7ERBB2, CDKN1A, EGFR, IFI27
12geldanamycin44 49 59 1113.7TP53, EGFR, CDKN1A, ERBB2
13gemcitabine44 49 1112.7ERBB2, CDKN1A, TP53, EGFR
14adpribose4410.7TP53, IFI27, CDKN1A, EGFR
15optimax4410.7IFI27, CDKN1A
16p000484410.7IFI27, CDKN1A
175fluorouracil4410.7CDKN1A, BIRC7, ERBB2, TP53, EGFR
18docetaxel44 49 59 1113.7EGFR, CDKN1A, ERBB2, TP53
19doxorubicin44 49 1112.7BIRC7, CDKN1A, TP53, EGFR, IFI27, ERBB2
20retinoid4410.7EGFR, TP53, CDKN1A, FABP12, FABP4, IFI27
21resveratrol44 59 11 2413.7ERBB2, CDKN1A, IFI27, TP53
22Afatinib1110.7EGFR, ERBB2
23paraffin4410.7IFI27, CDKN1A, EGFR, KRT13, ERBB2, TP53
24n acetylcysteine4410.7ERBB2, EGFR, TP53, IFI27, CDKN1A
25tamoxifen44 49 28 1113.7TP53, CDKN1A, EGFR, IFI27, ERBB2
26progesterone44 59 28 11 2414.7IFI27, EGFR, NR2F1, CDKN1A, ERBB2, HPGD
27paclitaxel44 49 1112.7TP53, ERBB2, CDKN1A, EGFR, IFI27
28indole-3-carbinol4410.7IFI27, CDKN1A, TP53
29cisplatin44 49 59 1113.7TP53, CDKN1A, EGFR, IFI27, BIRC7, ERBB2
30troglitazone44 28 59 1113.7KRT13, IFI27, FABP4, CDKN1A
31steroid4410.7ERBB2, FGF3, HPGD, FABP4, FABP5, IFI27
32vitamin d4410.7IFI27, CDKN1A, HPGD, KRT13, ERBB2
33mg 13244 5911.6IFI27, EGFR, CDKN1A, TP53
34vegf4410.6EGFR, IFI27, CDKN1A, FGF3, MMP10, ERBB2
35sulindac44 1111.6IFI27, TP53, CDKN1A
36batimastat44 59 1112.6EGFR, MMP10, ERBB2
37ly2940024410.6EGFR, CDKN1A, TP53, ERBB2, IFI27
38topotecan44 1111.6TP53, EGFR, ERBB2
39oligonucleotide4410.6NR2F1, CDKN1A, FGF3, MMP10, TP53, MZF1
40ag 1478 hydrochloride5910.6EGFR, ERBB2
41curcumin4410.6EGFR, CDKN1A, ERBB2, TP53
42ag 4905910.6EGFR, ERBB2
43jnj 28871063 hydrochloride5910.5ERBB2, EGFR
44retinoic acid44 2411.5ELK1, IFI27, FABP5, FABP4, FABP12, EGFR
45iressa5910.5EGFR, ERBB2
46pd1587804410.4EGFR, ERBB2
47pertuzumab44 49 1112.4ERBB2, EGFR
48serine4410.4ELK1, TP53, ERBB2, BIRC7, MMP10, HPGD
49n-(4-hydroxyphenyl)retinamide4410.3TP53, ERBB2, CDKN1A
50roscovitine4410.1TP53, CDKN1A, IFI27

GO Terms for genes affiliated with Bladder Transitional Cell Carcinoma

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16Gene Ontology
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Biological processes related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801510.5CDKN1A, FGF3, ERBB2, EGFR
2neurotrophin TRK receptor signaling pathwayGO:04801110.5EGFR, CDKN1A, FGF3, ERBB2, ELK1
3fibroblast growth factor receptor signaling pathwayGO:00854310.4EGFR, FGF3, ERBB2, CDKN1A
4Fc-epsilon receptor signaling pathwayGO:03809510.4EGFR, CDKN1A, FGF3, ERBB2
5innate immune responseGO:04508710.3EGFR, CDKN1A, ERBB2, ELK1, FGF3
6epidermal growth factor receptor signaling pathwayGO:00717310.3EGFR, CDKN1A, FGF3, ERBB2
7mitotic cell cycle arrestGO:07185010.1TP53, CDKN1A

Molecular functions related to Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.4ERBB2, EGFR
2epidermal growth factor-activated receptor activityGO:00500610.1ERBB2, EGFR

Products for genes affiliated with Bladder Transitional Cell Carcinoma

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Sources for Bladder Transitional Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet