BPDCN
MCID: BLS007
MIFTS: 29

Blastic Plasmacytoid Dendritic Cell (BPDCN) malady

Cancer diseases category

Summaries for Blastic Plasmacytoid Dendritic Cell

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MalaCards: Blastic Plasmacytoid Dendritic Cell, also known as blastic plasmacytoid dendritic cell neoplasm, is related to leukemia and acute leukemia. An important gene associated with Blastic Plasmacytoid Dendritic Cell is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are C-MYB transcription factor network and Lymphocyte Signaling. The compounds cycloheximide and hydralazine have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and tumorigenesis.

Aliases & Classifications for Blastic Plasmacytoid Dendritic Cell

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42NIH Rare Diseases, 60UMLS
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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

blastic plasmacytoid dendritic cell 42
blastic plasmacytoid dendritic cell neoplasm 42 60
bpdcn 42


Related Diseases for Blastic Plasmacytoid Dendritic Cell

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17GeneCards, 18GeneDecks
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Diseases related to Blastic Plasmacytoid Dendritic Cell via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2NPM1, MPO, NCAM1, CDKN2A, CD4, CDKN1B
2acute leukemia31.1IL3RA, NCAM1, MPO, NPM1
3myeloid leukemia30.9NPM1, MPO, IL3RA
4sarcoma30.5CD4
5myeloid sarcoma30.5NCAM1, MPO
6acute myeloid leukemia10.6
7cd4+/cd56+ hematodermic neoplasm10.5
8acute monocytic leukemia10.3
9cutaneous lupus erythematosus10.3
10dendritic cell sarcoma10.3
11leprosy10.3
12lupus erythematosus10.3
13melanoma10.3
14monocytic leukemia10.3
15prolymphocytic leukemia10.3
16carney complex10.0CDKN1B
17hepatoblastoma10.0NCAM1
18meningioma10.0NCAM1
19chordoma10.0NCAM1
20myelodysplastic syndromes10.0NPM1, MPO
21neuroblastoma10.0NCAM1
22plasma cell leukemia10.0NCAM1
23myelofibrosis10.0TET2
24adenoma10.0CDKN1B, CDKN2A
25central nervous system lymphoma10.0CD4
26chagas disease10.0CD4
27deficiency anemia10.0CD4
28multiple myeloma10.0CDKN2A, NCAM1
29herpes simplex10.0CD4
30hepatitis c10.0CD4
31gastritis10.0CD4
32pituitary adenoma10.0NCAM1, CDKN1B
33meningitis10.0CD4
34thyroiditis10.0CD4
35hepatitis10.0CD4
36papilloma10.0CDKN1B, CDKN2A
37atherosclerosis10.0MYD88, MPO
38acute myeloid leukemia, adult10.0NPM1, NCAM1
39oligodendroglioma10.0CDKN2A, NCAM1
40kidney cancer10.0CD4
41ovarian cancer10.0CDKN1B, CDKN2A, NPM1
42laryngeal benign neoplasm10.0CD4
43hematologic cancer10.0NPM1, CDKN1B, IL3RA
44kaposi's sarcoma10.0CD4
45malignant peripheral nerve sheath tumor10.0CDKN2A, NCAM1
46pituitary tumors10.0CDKN1B, NCAM1
47prostate cancer10.0NPM1, NCAM1, CDKN1B
48myocarditis10.0CD4
49reticulosarcoma10.0NPM1, CDKN1B
50inflammatory bowel disease10.0MPO, CD4

Graphical network of the top 20 diseases related to Blastic Plasmacytoid Dendritic Cell:



Diseases related to blastic plasmacytoid dendritic cell

Clinical Features for Blastic Plasmacytoid Dendritic Cell

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Drugs & Therapeutics for Blastic Plasmacytoid Dendritic Cell

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Blastic Plasmacytoid Dendritic Cell

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Anatomical Context for Blastic Plasmacytoid Dendritic Cell

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Animal Models for Blastic Plasmacytoid Dendritic Cell or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Blastic Plasmacytoid Dendritic Cell:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7MYD88, NPM1
2MP:00020068.8NPM1, MYD88, CDKN2A, CDKN1B, TET2
3MP:00030128.8MYD88, CDKN2A, CD4, CDKN1B, TET2
4MP:00053818.1SPIB, CDKN1B, CD4, CDKN2A, MYD88
5MP:00053977.5SPIB, NPM1, MPO, MYD88, CDKN2A, CD4
6MP:00053877.5NPM1, MPO, MYD88, CDKN2A, CD4, CDKN1B
7MP:00053847.2NPM1, NCAM1, MYD88, CDKN2A, CD4, CDKN1B
8MP:00107687.0NPM1, MPO, NCAM1, MYD88, CDKN2A, CD4

Publications for Blastic Plasmacytoid Dendritic Cell

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Genetic Variations for Blastic Plasmacytoid Dendritic Cell

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Expression for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blastic Plasmacytoid Dendritic Cell

Search GEO for disease gene expression data for Blastic Plasmacytoid Dendritic Cell.

Pathways for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 53Reactome
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Pathways related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDKN1B, CD4, MPO
29.1CD4, MYD88, NCAM1, MPO
3
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9.0IL3RA, CDKN1B, CD4, MYD88
4
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8.6NCAM1, MYD88, CD4, CDKN1B, IL3RA

Compounds for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.2CD4
2hydralazine44 49 1112.0CDKN2A, MPO
3cytarabine44 49 1111.9CDKN1B, CDKN2A, MPO
4daunorubicin44 49 1111.8CDKN2A, MPO, NPM1
5[alcl]449.8NPM1, CDKN1B
6formaldehyde44 2410.7MPO, CD4, CDKN1B
7camptothecin44 59 1111.7CDKN1B, CDKN2A, NPM1
8chloramphenicol44 2 1111.5CD4, CDKN2A, MPO
9fatty acid449.4NPM1, MYD88, CDKN2A, CDKN1B
10doxorubicin44 49 1111.4CDKN1B, CDKN2A, NCAM1, NPM1
115fluorouracil449.3MPO, CDKN2A, CDKN1B
12heparin44 28 11 2412.3MPO, NCAM1, CD4, CDKN1B
13leucine449.3NPM1, CDKN2A, CD4, CDKN1B
1412-o-tetradecanoylphorbol 13-acetate449.2NCAM1, CD4, CDKN1B, IL3RA
15nitric oxide44 11 2411.2MPO, NCAM1, MYD88, CDKN2A, CDKN1B
16paraffin449.1NPM1, MPO, NCAM1, CDKN2A, CDKN1B
17progesterone44 59 28 11 2413.0CDKN1B, CD4, CDKN2A, NCAM1
18retinoic acid44 2410.0NPM1, MPO, NCAM1, CDKN2A, CDKN1B
19alanine449.0NPM1, NCAM1, CDKN2A, CD4, CDKN1B
20atp44 289.9NPM1, NCAM1, MYD88, CDKN2A, CDKN1B
21phosphatidylinositol448.9NCAM1, MYD88, CD4, CDKN1B, IL3RA
22serine448.3MPO, NCAM1, MYD88, CDKN2A, CD4, CDKN1B
23threonine447.7TCL1A, NPM1, NCAM1, MYD88, CDKN2A, CD4
24tyrosine447.0NPM1, NCAM1, LILRA4, MYD88, CD4, CDKN1B

GO Terms for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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16Gene Ontology
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Biological processes related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.8CDKN1B, CDKN2A
2negative regulation of phosphorylationGO:0423269.6CDKN1B, CDKN2A
3negative regulation of apoptotic processGO:0430669.1CDKN1B, MYD88, MPO, NPM1

Molecular functions related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.7CDKN2A, NPM1
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN1B, CDKN2A

Products for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Sources for Blastic Plasmacytoid Dendritic Cell

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet