BPDCN
MCID: BLS007
MIFTS: 37

Blastic Plasmacytoid Dendritic Cell (BPDCN) malady

Cancer category

Summaries for Blastic Plasmacytoid Dendritic Cell

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MalaCards: Blastic Plasmacytoid Dendritic Cell, also known as blastic plasmacytoid dendritic cell neoplasm, is related to plasma cell leukemia and acute leukemia. An important gene associated with Blastic Plasmacytoid Dendritic Cell is CDKN1B (cyclin-dependent kinase inhibitor 1B (p27, Kip1)), and among its related pathways are C-MYB transcription factor network and Lymphocyte Signaling. The compounds cycloheximide and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung, and related mouse phenotypes are vision/eye and tumorigenesis.

Aliases & Classifications for Blastic Plasmacytoid Dendritic Cell

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43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

blastic plasmacytoid dendritic cell 43
blastic plasmacytoid dendritic cell neoplasm 43 61
bpdcn 43


Related Diseases for Blastic Plasmacytoid Dendritic Cell

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17GeneCards, 18GeneDecks
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Diseases related to Blastic Plasmacytoid Dendritic Cell via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1plasma cell leukemia31.3NCAM1
2acute leukemia31.1IL3RA, NCAM1, MPO, NPM1
3myeloid sarcoma30.5NCAM1, MPO
4t-cell leukemia10.8
5acute myeloid leukemia10.7
6acute t cell leukemia10.6
7hematopoietic stem cell transplantation10.5
8cd4+/cd56+ hematodermic neoplasm10.5
9acute monocytic leukemia10.4
10cutaneous lupus erythematosus10.4
11b cell prolymphocytic leukemia10.4
12post-transplant lymphoproliferative disease10.4
13leukemia/lymphoma, t-cell10.4
14t-cell prolymphocytic leukemia10.4
15carney complex10.0CDKN1B
16hepatoblastoma10.0NCAM1
17meningioma10.0NCAM1
18chordoma10.0NCAM1
19myelodysplastic syndromes10.0NPM1, MPO
20neuroblastoma10.0NCAM1
21myelofibrosis10.0TET2
22adenoma10.0CDKN1B, CDKN2A
23sarcoma10.0CD4
24central nervous system lymphoma10.0CD4
25chagas disease10.0CD4
26deficiency anemia10.0CD4
27multiple myeloma10.0CDKN2A, NCAM1
28herpes simplex10.0CD4
29hepatitis c10.0CD4
30gastritis10.0CD4
31pituitary adenoma10.0NCAM1, CDKN1B
32meningitis10.0CD4
33thyroiditis10.0CD4
34hepatitis10.0CD4
35papilloma10.0CDKN1B, CDKN2A
36myeloid leukemia10.0NPM1, MPO, IL3RA
37atherosclerosis10.0MYD88, MPO
38acute myeloid leukemia, adult10.0NPM1, NCAM1
39oligodendroglioma10.0CDKN2A, NCAM1
40kidney cancer10.0CD4
41ovarian cancer10.0CDKN1B, CDKN2A, NPM1
42laryngeal carcinoma10.0CD4
43hematologic cancer10.0NPM1, CDKN1B, IL3RA
44kaposi's sarcoma10.0CD4
45malignant peripheral nerve sheath tumor10.0CDKN2A, NCAM1
46pituitary tumors10.0CDKN1B, NCAM1
47prostate cancer10.0NPM1, NCAM1, CDKN1B
48myocarditis10.0CD4
49reticulosarcoma10.0NPM1, CDKN1B
50inflammatory bowel disease10.0MPO, CD4

Graphical network of the top 20 diseases related to Blastic Plasmacytoid Dendritic Cell:



Diseases related to blastic plasmacytoid dendritic cell

Clinical Features for Blastic Plasmacytoid Dendritic Cell

Drugs & Therapeutics for Blastic Plasmacytoid Dendritic Cell

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Blastic Plasmacytoid Dendritic Cell

Anatomical Context for Blastic Plasmacytoid Dendritic Cell

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33MalaCards
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MalaCards organs/tissues related to Blastic Plasmacytoid Dendritic Cell:

33
Skin, Lymph node, Lung, Bone marrow, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Blastic Plasmacytoid Dendritic Cell or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Blastic Plasmacytoid Dendritic Cell:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7MYD88, NPM1
2MP:00020068.8NPM1, MYD88, CDKN2A, CDKN1B, TET2
3MP:00030128.8MYD88, CDKN2A, CD4, CDKN1B, TET2
4MP:00053818.1SPIB, CDKN1B, CD4, CDKN2A, MYD88
5MP:00053977.5SPIB, NPM1, MPO, MYD88, CDKN2A, CD4
6MP:00053877.5NPM1, MPO, MYD88, CDKN2A, CD4, CDKN1B
7MP:00053847.2NPM1, NCAM1, MYD88, CDKN2A, CD4, CDKN1B
8MP:00107687.0NPM1, MPO, NCAM1, MYD88, CDKN2A, CD4

Publications for Blastic Plasmacytoid Dendritic Cell

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51PubMed
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Articles related to Blastic Plasmacytoid Dendritic Cell:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Diffuse lung metastases in a child with blastic plasmacytoid dendritic cell neoplasm and review. (24384793)
2014
2
Morphologic characteristics of blastic plasmacytoid dendritic cell neoplasm: a case report. (23957370)
2014
3
Blastic plasmacytoid dendritic cell neoplasm with EWSR1 gene rearrangement. (24025453)
2014
4
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation. (23203822)
2013
5
L-asparaginase with methotrexate and dexamethasone is an effective treatment combination in blastic plasmacytoid dendritic cell neoplasm. (23937331)
2013
6
Blastic Plasmacytoid Dendritic Cell Neoplasm: Evolving Insights in an Aggressive Hematopoietic Malignancy With a Predilection of Skin Involvement. (24247574)
2013
7
Blastic plasmacytoid dendritic cell neoplasm in an elderly woman. (23629565)
2013
8
Sustained complete remission in an elderly patient with a blastic plasmacytoid dendritic cell neoplasm following autologous peripheral blood stem cell transplantation. (23435845)
2013
9
Immunohistochemical analysis of CD123, CD56 and CD4 for the diagnosis of minimal bone marrow involvement by blastic plasmacytoid dendritic cell neoplasm. (23470050)
2013
10
Skin lesions in a patient with blastic plasmacytoid dendritic cell neoplasm. (24372537)
2013
11
Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm? (24312342)
2013
12
A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm. (23300173)
2013
13
Childhood blastic plasmacytoid dendritic cell neoplasm treated with allogenic stem cell transplantation. (22300352)
2013
14
Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose DeVIC therapy and radiation therapy: a case report and review of the literature. (24228127)
2013
15
Blastic plasmacytoid dendritic cell neoplasm: a report of 2 cases. (24426367)
2013
16
Case study interpretation-New Orleans: case 5. Blastic plasmacytoid dendritic cell neoplasm. (23283843)
2013
17
Blastic plasmacytoid dendritic cell neoplasm. (24346907)
2013
18
Efficacy of acute myeloid leukemia therapy without stem-cell transplantation in a child with blastic plasmacytoid dendritic cell neoplasm. (23449596)
2013
19
Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature. (23788509)
2013
20
Unrelated SCT induces long-term remission in patients with blastic plasmacytoid dendritic cell neoplasm. (23208316)
2013
21
Blastic plasmacytoid dendritic cell neoplasm. (24266391)
2013
22
Rapidly enlarging nodule on the scalp. Blastic plasmacytoid dendritic cell neoplasm (BPDCN). (23759925)
2013
23
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
24
Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry is useful for blastic plasmacytoid dendritic cell leukemia diagnosis. (22674796)
2012
25
Loss of genomic DNA copy numbers in the p18, p16, p27 and RB loci in blastic plasmacytoid dendritic cell neoplasm. (22361914)
2012
26
Excessive therapeutic response in a case of blastic plasmacytoid dendritic cell neoplasm. (22398810)
2012
27
Blastic plasmacytoid dendritic cell neoplasm without cutaneous involvement: a rare disease with a rare presentation. (21871006)
2012
28
Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. (22338048)
2012
29
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review. (21890199)
2012
30
Blastic plasmacytoid dendritic cell neoplasm. (21953644)
2012
31
Blastic plasmacytoid dendritic cell neoplasm: is it time to redefine the standard of care? (22992228)
2012
32
Blastic plasmacytoid dendritic cell neoplasm. (23213649)
2012
33
Blastic plasmacytoid dendritic cell neoplasm. (22398811)
2012
34
Allogeneic stem-cell transplantation for blastic plasmacytoid dendritic cell neoplasm. (22331943)
2012
35
Blastic plasmacytoid dendritic cell neoplasm without cutaneous lesion at presentation: case report and literature review. (22236870)
2012
36
Case of blastic plasmacytoid dendritic cell neoplasm. (22970734)
2012
37
Cutaneous accumulation of plasmacytoid dendritic cells associated with acute myeloid leukemia: a rare condition distinct from blastic plasmacytoid dendritic cell neoplasm. (21883371)
2011
38
An unusual case of cutaneous blastic plasmacytoid dendritic cell neoplasm with concomitant B-cell lymphoproliferative disorder. (20861710)
2011
39
Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm. (21628861)
2011
40
Treatment of blastic plasmacytoid dendritic cell neoplasms with cord blood transplants. (22402468)
2011
41
Twenty-one cases of blastic plasmacytoid dendritic cell neoplasm: focus on biallelic locus 9p21.3 deletion. (21900200)
2011
42
Blastic plasmacytoid dendritic cell neoplasia (BPDC) in elderly patients: results of a treatment algorithm employing allogeneic stem cell transplantation with moderately reduced conditioning intensity. (21215813)
2011
43
Blastic plasmacytoid dendritic cell neoplasm should be treated with acute leukemia type induction chemotherapy and allogeneic stem cell transplantation in first remission. (20697854)
2010
44
Blastic plasmacytoid dendritic cell neoplasm presenting as a subcutaneous mass in an 8-year-old boy. (20552185)
2010
45
A case of cutaneous blastic plasmacytoid dendritic cell neoplasm. (21057756)
2010
46
Necklace-like microvacuoles of tumor cells in blastic plasmacytoid dendritic cell neoplasm. (21120156)
2010
47
Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients. (19956058)
2010
48
Cutaneous blastic plasmacytoid dendritic cell neoplasm associated with anaemia and thrombocytopaenia. (19997703)
2009
49
Philadelphia chromosome-positive blastic plasmacytoid dendritic cell leukemia. (19963123)
2009
50
Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis. (19684511)
2009

Genetic Variations for Blastic Plasmacytoid Dendritic Cell

Expression for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blastic Plasmacytoid Dendritic Cell

Search GEO for disease gene expression data for Blastic Plasmacytoid Dendritic Cell.

Pathways for genes affiliated with Blastic Plasmacytoid Dendritic Cell

Sources:
38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 54Reactome
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Pathways related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDKN1B, CD4, MPO
29.1CD4, MYD88, NCAM1, MPO
3
Hide members
9.0IL3RA, CDKN1B, CD4, MYD88
4
Hide members
8.6NCAM1, MYD88, CD4, CDKN1B, IL3RA

Compounds for genes affiliated with Blastic Plasmacytoid Dendritic Cell

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB, 29IUPHAR
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Compounds related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.2CD4
2hydralazine45 50 1112.0CDKN2A, MPO
3cytarabine45 50 1111.9CDKN1B, CDKN2A, MPO
4daunorubicin45 50 1111.8CDKN2A, MPO, NPM1
5[alcl]459.8NPM1, CDKN1B
6formaldehyde45 2410.7MPO, CD4, CDKN1B
7camptothecin45 60 1111.7CDKN1B, CDKN2A, NPM1
8chloramphenicol45 2 1111.5CD4, CDKN2A, MPO
9fatty acid459.4NPM1, MYD88, CDKN2A, CDKN1B
10doxorubicin45 50 1111.4CDKN1B, CDKN2A, NCAM1, NPM1
115fluorouracil459.3MPO, CDKN2A, CDKN1B
12heparin45 29 11 2412.3MPO, NCAM1, CD4, CDKN1B
13leucine459.3NPM1, CDKN2A, CD4, CDKN1B
1412-o-tetradecanoylphorbol 13-acetate459.2NCAM1, CD4, CDKN1B, IL3RA
15nitric oxide45 11 2411.2MPO, NCAM1, MYD88, CDKN2A, CDKN1B
16paraffin459.1NPM1, MPO, NCAM1, CDKN2A, CDKN1B
17progesterone45 60 29 11 2413.0CDKN1B, CD4, CDKN2A, NCAM1
18retinoic acid45 2410.0NPM1, MPO, NCAM1, CDKN2A, CDKN1B
19alanine459.0NPM1, NCAM1, CDKN2A, CD4, CDKN1B
20atp45 299.9NPM1, NCAM1, MYD88, CDKN2A, CDKN1B
21phosphatidylinositol458.9NCAM1, MYD88, CD4, CDKN1B, IL3RA
22serine458.3MPO, NCAM1, MYD88, CDKN2A, CD4, CDKN1B
23threonine457.7TCL1A, NPM1, NCAM1, MYD88, CDKN2A, CD4
24tyrosine457.0NPM1, NCAM1, LILRA4, MYD88, CD4, CDKN1B

GO Terms for genes affiliated with Blastic Plasmacytoid Dendritic Cell

Sources:
16Gene Ontology
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Biological processes related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.8CDKN1B, CDKN2A
2negative regulation of phosphorylationGO:0423269.6CDKN1B, CDKN2A
3negative regulation of apoptotic processGO:0430669.1CDKN1B, MYD88, MPO, NPM1

Molecular functions related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NF-kappaB bindingGO:0510599.7CDKN2A, NPM1
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN1B, CDKN2A

Products for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Sources for Blastic Plasmacytoid Dendritic Cell

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet