BPDCN
MCID: BLS007
MIFTS: 45

Blastic Plasmacytoid Dendritic Cell (BPDCN) malady

Rare diseases, Cancer diseases categories
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Summaries for Blastic Plasmacytoid Dendritic Cell

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MalaCards based summary: Blastic Plasmacytoid Dendritic Cell, also known as blastic plasmacytoid dendritic cell neoplasm, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Blastic Plasmacytoid Dendritic Cell is TET2 (tet methylcytosine dioxygenase 2), and among its related pathways are Notch-mediated HES/HEY network and Malaria. The compounds [alcl] and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, skin and bone marrow, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Blastic Plasmacytoid Dendritic Cell

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Blastic Plasmacytoid Dendritic Cell, Aliases & Descriptions:

Name: Blastic Plasmacytoid Dendritic Cell 42
Blastic Plasmacytoid Dendritic Cell Neoplasm 42 62
 
Bpdcn 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Blastic Plasmacytoid Dendritic Cell

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Diseases related to Blastic Plasmacytoid Dendritic Cell via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia31.2NPM1, MPO, IL3RA
2myeloid sarcoma30.7NCAM1, MPO
3b-cell lymphomas30.4CDKN1B, NPM1, TCL1A, CDKN2A
4acute leukemia30.2MPO, NPM1, NCAM1, IL3RA
5leukemia29.2TCL1A, TET2, SPIB, PECAM1, MPO, CD4
6acute myeloid leukemia10.7
7hematopoietic stem cell transplantation10.5
8cd4+/cd56+ hematodermic neoplasm10.5
9acute monocytic leukemia10.4
10post-transplant lymphoproliferative disease10.4
11cutaneous lupus erythematosus10.4
12leprosy10.4
13lupus erythematosus10.4
14melanoma10.4
15meningitis10.4
16monocytic leukemia10.4
17purpura10.4
18sarcoma10.4
19dendritic cell tumor10.4
20endotheliitis10.4
21progressive multifocal leukoencephalopathy10.3CD4, SPIB
22kaposi's sarcoma10.3CD4
23chronic lymphocytic leukemia10.2TCL1A, IL3RA, CD4
24cervical adenocarcinoma10.2CDKN1B, CDKN2A
25cervical squamous cell carcinoma10.2CDKN1B, CDKN2A
26reticulosarcoma10.2CDKN1B, NPM1
27skin disease10.2MPO, CD4
28eosinophilia10.1MPO, CD4, IL3RA
29periodontal disease10.1CD4, MPO
30hematologic cancer10.1CDKN1B, IL3RA, NPM1
31pneumonia10.1CD4, MPO, MYD88
32anaplastic large cell lymphoma10.1NPM1, CDKN1B, CD4
33leukemia, acute lymphoblastic 310.1MPO, CDKN2A
34acute myeloid leukemia, adult10.0NPM1, NCAM1
35acute lymphoblastic leukemia10.0CDKN2A, IL3RA, MPO
36peripheral t-cell lymphoma10.0CD4, TCL1A, NCAM1
37cervical cancer10.0CDKN2A, CDKN1B, CD4
38malignant peripheral nerve sheath tumor10.0NCAM1, CDKN2A
39lung adenocarcinoma9.9CDKN1B, PECAM1, CDKN2A
40immunodeficiency with hyper igm type 29.9CD4, NCAM1, TCL1A
41leukopenia9.9NCAM1, CD4, MPO
42peritonitis9.9PECAM1, MPO
43non-hodgkin lymphoma9.9TCL1A, NPM1, PECAM1, CDKN1B
44arthritis9.9MPO, PECAM1, CD4
45precursor t-cell acute lymphoblastic leukemia9.8MPO, CD4, CDKN2A, CDKN1B
46myeloma9.8NCAM1, TCL1A, CD4
47lung benign neoplasm9.8PECAM1, CDKN2A, NCAM1
48liver cancer9.7CD4, NPM1, CDKN2A, CDKN1B
49hypersensitivity reaction type ii disease9.7NCAM1, CD4, MYD88, PECAM1
50acute promyelocytic leukemia9.7CDKN1B, NPM1, NCAM1, MPO

Graphical network of the top 20 diseases related to Blastic Plasmacytoid Dendritic Cell:



Diseases related to blastic plasmacytoid dendritic cell

Symptoms for Blastic Plasmacytoid Dendritic Cell

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Drugs & Therapeutics for Blastic Plasmacytoid Dendritic Cell

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Drug clinical trials:

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Genetic Tests for Blastic Plasmacytoid Dendritic Cell

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Anatomical Context for Blastic Plasmacytoid Dendritic Cell

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MalaCards organs/tissues related to Blastic Plasmacytoid Dendritic Cell:

32
Myeloid, Skin, Bone marrow, Bone, Lung, B cells, Lymph node, Breast, Monocytes, Nk cells, T cells, Endothelial

Animal Models for Blastic Plasmacytoid Dendritic Cell or affiliated genes

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MGI Mouse Phenotypes related to Blastic Plasmacytoid Dendritic Cell:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1TET2, MYD88, NPM1, CDKN2A, CDKN1B
2MP:00030129.0TET2, MYD88, CD4, CDKN2A, CDKN1B
3MP:00053708.8TET2, PECAM1, NPM1, CDKN2A, CDKN1B
4MP:00053918.8CDKN1B, CDKN2A, NPM1, NCAM1, MYD88
5MP:00053858.2TET2, PECAM1, MPO, MYD88, NPM1, CDKN1B
6MP:00053788.1TET2, MYD88, NCAM1, NPM1, CD4, CDKN2A
7MP:00053818.1SPIB, PECAM1, MYD88, CD4, CDKN2A, CDKN1B
8MP:00053977.3CDKN1B, TET2, SPIB, PECAM1, MPO, MYD88
9MP:00107687.3TET2, SPIB, MPO, MYD88, NCAM1, NPM1
10MP:00053877.3TET2, SPIB, PECAM1, MPO, MYD88, NPM1
11MP:00053847.2TET2, SPIB, PECAM1, MYD88, NCAM1, NPM1

Publications for Blastic Plasmacytoid Dendritic Cell

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Articles related to Blastic Plasmacytoid Dendritic Cell:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Two rare cases of blastic plasmacytoid dendritic cell neoplasm and a literature review. (24432892)
2014
2
Cutaneous lesions of a blastic plasmacytoid dendritic cell neoplasm. (24531095)
2014
3
Meningeal spread of blastic plasmacytoid dendritic cell neoplasm. (24483771)
2014
4
A Case Report: Blastic Plasmacytoid Dendritic Cell Neoplasm Is Misdiagnosed as Breast Infiltrating Ductal Carcinoma. (25297609)
2014
5
Sustained remission of blastic plasmacytoid dendritic cell neoplasm after unrelated allogeneic stem cell transplantation-a single center experience. (25138222)
2014
6
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm: laboratory approaches in 2 cases. (25325042)
2014
7
Blastic plasmacytoid dendritic cell neoplasm: the first report of two cases treated by 5-azacytidine. (24571716)
2014
8
Blastic plasmacytoid dendritic cell neoplasm. (23582004)
2013
9
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation. (23203822)
2013
10
L-asparaginase with methotrexate and dexamethasone is an effective treatment combination in blastic plasmacytoid dendritic cell neoplasm. (23937331)
2013
11
Blastic Plasmacytoid Dendritic Cell Neoplasm: Evolving Insights in an Aggressive Hematopoietic Malignancy With a Predilection of Skin Involvement. (24247574)
2013
12
Blastic plasmacytoid dendritic cell neoplasm in an elderly woman. (23629565)
2013
13
Lung involvement at initial presentation in blastic plasmacytoid dendritic cell neoplasm lacking cutaneous lesion. (22933234)
2013
14
Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature. (22455538)
2013
15
Reply to "A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm" and to "A low-grade B-cell lymphoma with prolymphocytic/paraimmunoblastic proliferation and IRF4 rearrangement" dendritic cell leukemia. (23449597)
2013
16
SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms. (23165482)
2013
17
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. (23065521)
2013
18
TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow. (23940084)
2013
19
Sustained complete remission in an elderly patient with a blastic plasmacytoid dendritic cell neoplasm following autologous peripheral blood stem cell transplantation. (23435845)
2013
20
Immunohistochemical analysis of CD123, CD56 and CD4 for the diagnosis of minimal bone marrow involvement by blastic plasmacytoid dendritic cell neoplasm. (23470050)
2013
21
Skin lesions in a patient with blastic plasmacytoid dendritic cell neoplasm. (24372537)
2013
22
Unusual Morphologic Presentations of Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of Two Cases Misdiagnosed as Melanoma and Leprosy. (23515558)
2013
23
Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm? (24312342)
2013
24
A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm. (23300173)
2013
25
Childhood blastic plasmacytoid dendritic cell neoplasm treated with allogenic stem cell transplantation. (22300352)
2013
26
Blastic plasmacytoid dendritic cell neoplasm in a human T-cell lymphotropic virus type I (HTLV-1) carrier: a coincidental association? (23558032)
2013
27
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
28
Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry is useful for blastic plasmacytoid dendritic cell leukemia diagnosis. (22674796)
2012
29
Loss of genomic DNA copy numbers in the p18, p16, p27 and RB loci in blastic plasmacytoid dendritic cell neoplasm. (22361914)
2012
30
Blastic plasmacytoid dendritic cell neoplasm in a child. (22583725)
2012
31
Cutaneous blastic plasmacytoid dendritic cell neoplasm occurring after spontaneous remission of acute myeloid leukemia: a case report and review of literature. (22476762)
2012
32
Congenital blastic plasmacytoid dendritic cell neoplasm. (21744480)
2012
33
Excessive therapeutic response in a case of blastic plasmacytoid dendritic cell neoplasm. (22398810)
2012
34
Blastic plasmacytoid dendritic cell neoplasm without cutaneous involvement: a rare disease with a rare presentation. (21871006)
2012
35
Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. (22338048)
2012
36
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review. (21890199)
2012
37
Cutaneous accumulation of plasmacytoid dendritic cells associated with acute myeloid leukemia: a rare condition distinct from blastic plasmacytoid dendritic cell neoplasm. (21883371)
2011
38
An unusual case of cutaneous blastic plasmacytoid dendritic cell neoplasm with concomitant B-cell lymphoproliferative disorder. (20861710)
2011
39
Primary cutaneous blastic plasmacytoid dendritic cell neoplasm without extracutaneous manifestation: case report and review of the literature. (20573459)
2011
40
Blastic plasmacytoid dendritic cell neoplasm. (20940186)
2011
41
Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm. (21628861)
2011
42
Blastic plasmacytoid dendritic cell neoplasm presenting as a renal mass. (21939455)
2011
43
Blastic plasmacytoid dendritic cell neoplasm on the scalp. (22220144)
2011
44
Blastic plasmacytoid dendritic cell neoplasm should be treated with acute leukemia type induction chemotherapy and allogeneic stem cell transplantation in first remission. (20697854)
2010
45
Blastic plasmacytoid dendritic cell neoplasm presenting as a subcutaneous mass in an 8-year-old boy. (20552185)
2010
46
Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms. (19924135)
2010
47
A case of blastic plasmacytoid dendritic cell neoplasm initially mimicking cutaneous lupus erythematosus. (21253327)
2010
48
Blastic plasmacytoid dendritic cell neoplasm: is transplantation the treatment of choice? (19689477)
2010
49
Cutaneous blastic plasmacytoid dendritic cell neoplasm associated with anaemia and thrombocytopaenia. (19997703)
2009
50
Philadelphia chromosome-positive blastic plasmacytoid dendritic cell leukemia. (19963123)
2009

Variations for Blastic Plasmacytoid Dendritic Cell

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Expression for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Expression patterns in normal tissues for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Pathways for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Compounds for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Compounds related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1[alcl]4410.2CDKN1B, NPM1
2hydralazine44 50 1112.1CDKN2A, MPO
3p000014410.0CDKN1B, CDKN2A
45 aminosalicylic acid4410.0PECAM1, MPO
5nickel44 2411.0CD4, CDKN2A
6cytarabine44 50 1111.9CDKN1B, CDKN2A, MPO
7daunorubicin44 50 1111.8CDKN2A, NPM1, MPO
8camptothecin44 61 1111.8CDKN1B, CDKN2A, NPM1
95fluorouracil449.8CDKN1B, CDKN2A, MPO
10rrna449.8CDKN2A, NPM1
11chloramphenicol44 2 50 1112.7CDKN2A, CD4, MPO
12methanol44 2410.7CDKN2A, MPO
13n acetylcysteine449.7CDKN1B, CDKN2A, MPO
14rantes449.7PECAM1, MYD88, CD4
15hematoxylin449.7PECAM1, NCAM1, CDKN2A
16agar449.6PECAM1, CDKN2A, CDKN1B
17butyrate449.6CDKN1B, CDKN2A, MPO
18fatty acid449.6MYD88, NPM1, CDKN2A, CDKN1B
19formaldehyde44 2410.5PECAM1, MPO, CD4, CDKN1B
20paclitaxel44 50 1111.5NPM1, CDKN2A, CDKN1B
21leucine449.5NPM1, CD4, CDKN2A, CDKN1B
22oligonucleotide449.5CDKN1B, CDKN2A, CD4, MYD88
23doxorubicin44 50 1111.5CDKN1B, CDKN2A, NPM1, NCAM1
24progesterone44 28 61 24 1113.5NCAM1, CD4, CDKN2A, CDKN1B
25actinomycin d449.4CDKN1B, CDKN2A, NPM1, PECAM1
26rapamycin449.4CDKN1B, NPM1, PECAM1
27h2o2449.4CDKN1B, CDKN2A, MPO, PECAM1
28cholesterol44 28 24 1112.4PECAM1, CD4, CDKN2A, CDKN1B
2912-o-tetradecanoylphorbol 13-acetate449.3CDKN1B, CD4, NCAM1, IL3RA
30oxygen44 2410.2PECAM1, MPO, MYD88, CDKN2A, CDKN1B
31alanine449.2NCAM1, NPM1, CD4, CDKN2A, CDKN1B
32cycloheximide449.1PECAM1, NPM1, CD4, CDKN2A, CDKN1B
33heparin44 28 24 1112.1PECAM1, MPO, NCAM1, CD4, CDKN1B
34vegf449.0PECAM1, MPO, NCAM1, CDKN2A, CDKN1B
35lipid449.0PECAM1, MYD88, NCAM1, CD4, CDKN2A
36phosphatidylinositol449.0MYD88, IL3RA, NCAM1, CD4, CDKN1B
37estrogen449.0PECAM1, NCAM1, NPM1, CDKN2A, CDKN1B
38histamine44 28 2411.0PECAM1, MPO, NCAM1
39cysteine449.0PECAM1, NCAM1, NPM1, CD4, CDKN2A
40nitric oxide44 24 1110.8PECAM1, MPO, MYD88, NCAM1, CDKN2A, CDKN1B
41atp44 289.8PECAM1, MYD88, NCAM1, NPM1, CDKN2A, CDKN1B
42paraffin448.7PECAM1, MPO, NCAM1, NPM1, CDKN2A, CDKN1B
43retinoic acid44 249.7PECAM1, MPO, NCAM1, NPM1, CDKN2A, CDKN1B
44calcium44 50 24 1111.6PECAM1, MPO, NCAM1, NPM1, CD4, CDKN2A
45serine448.0PECAM1, MPO, MYD88, TCL1A, NCAM1, CD4
46threonine447.3CDKN1B, PECAM1, MYD88, TCL1A, IL3RA, NCAM1
47tyrosine446.9SPIB, PECAM1, MYD88, LILRA4, IL3RA, NCAM1

GO Terms for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Biological processes related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:0423269.8CDKN1B, CDKN2A
2negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN1B, CDKN2A
3negative regulation of apoptotic processGO:0430669.2CDKN1B, NPM1, MYD88, MPO

Molecular functions related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.8CDKN1B, CDKN2A
2NF-kappaB bindingGO:0510599.5CDKN2A, NPM1
3protein kinase bindingGO:0199019.5CDKN2A, CD4, NPM1
4protein bindingGO:0055157.1TET2, PECAM1, MYD88, LILRA4, TCL1A, NPM1

Products for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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3CDC
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