BPDCN
MCID: BLS007
MIFTS: 44

Blastic Plasmacytoid Dendritic Cell (BPDCN) malady

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Summaries for Blastic Plasmacytoid Dendritic Cell

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MalaCards: Blastic Plasmacytoid Dendritic Cell, also known as blastic plasmacytoid dendritic cell neoplasm, is related to myeloid leukemia and leukemia. An important gene associated with Blastic Plasmacytoid Dendritic Cell is TET2 (tet methylcytosine dioxygenase 2), and among its related pathways are Notch-mediated HES/HEY network and Malaria. The compounds [alcl] and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, skin and bone marrow, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Blastic Plasmacytoid Dendritic Cell

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43NIH Rare Diseases, 62UMLS
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Classifications:

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Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

blastic plasmacytoid dendritic cell 43
blastic plasmacytoid dendritic cell neoplasm 43 62
bpdcn 43


Related Diseases for Blastic Plasmacytoid Dendritic Cell

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Diseases related to Blastic Plasmacytoid Dendritic Cell via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia31.0MPO, IL3RA, NPM1
2leukemia30.9CDKN1B, TET2, SPIB, PECAM1, MPO, TCL1A
3myeloid sarcoma30.6NCAM1, MPO
4b-cell lymphomas30.5CDKN1B, CDKN2A, NPM1, TCL1A
5acute leukemia30.5MPO, IL3RA, NCAM1, NPM1
6acute myeloid leukemia10.7
7hematopoietic stem cell transplantation10.5
8cd4+/cd56+ hematodermic neoplasm10.5
9acute monocytic leukemia10.4
10cutaneous lupus erythematosus10.4
11leprosy10.4
12lupus erythematosus10.4
13melanoma10.4
14monocytic leukemia10.4
15sarcoma10.4
16post-transplant lymphoproliferative disease10.4
17endotheliitis10.4
18progressive multifocal leukoencephalopathy10.1SPIB, CD4
19kaposi's sarcoma10.1CD4
20chronic lymphocytic leukemia10.0CD4, IL3RA, TCL1A
21cervical adenocarcinoma10.0CDKN1B, CDKN2A
22reticulosarcoma10.0CDKN1B, NPM1
23cervical squamous cell carcinoma10.0CDKN2A, CDKN1B
24skin disease10.0MPO, CD4
25eosinophilia10.0CD4, IL3RA, MPO
26periodontal disease10.0MPO, CD4
27hematologic cancer10.0CDKN1B, NPM1, IL3RA
28b-cell chronic lymphocytic leukemia10.0CDKN1B, TCL1A, PECAM1
29pneumonia10.0MPO, MYD88, CD4
30anaplastic large cell lymphoma10.0NPM1, CD4, CDKN1B
31leukemia, acute lymphoblastic 310.0MPO, CDKN2A
32acute myeloid leukemia, adult10.0NPM1, NCAM1
33acute lymphocytic leukemia10.0CDKN2A, IL3RA, MPO
34peripheral t-cell lymphoma10.0TCL1A, NCAM1, CD4
35cervical cancer10.0CD4, CDKN2A, CDKN1B
36malignant peripheral nerve sheath tumor10.0NCAM1, CDKN2A
37lung adenocarcinoma10.0CDKN1B, CDKN2A, PECAM1
38immunodeficiency with hyper igm type 210.0CD4, NCAM1, TCL1A
39leukopenia10.0MPO, NCAM1, CD4
40peritonitis10.0MPO, PECAM1
41non-hodgkin lymphoma10.0CDKN1B, NPM1, TCL1A, PECAM1
42arthritis10.0CD4, MPO, PECAM1
43precursor t-cell acute lymphoblastic leukemia10.0CDKN1B, CDKN2A, CD4, MPO
44myeloma10.0CD4, NCAM1, TCL1A
45lung benign neoplasm9.9CDKN2A, NCAM1, PECAM1
46hepatocellular carcinoma9.9CDKN1B, CDKN2A, CD4, NPM1
47hypersensitivity reaction type ii disease9.9PECAM1, MYD88, NCAM1, CD4
48acute promyelocytic leukemia9.9MPO, NCAM1, NPM1, CDKN1B
49colon cancer9.9PECAM1, NCAM1, CD4, CDKN1B
50astrocytoma9.9NCAM1, CD4, CDKN2A, CDKN1B

Graphical network of the top 20 diseases related to Blastic Plasmacytoid Dendritic Cell:



Diseases related to blastic plasmacytoid dendritic cell

Symptoms for Blastic Plasmacytoid Dendritic Cell

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Drugs & Therapeutics for Blastic Plasmacytoid Dendritic Cell

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Blastic Plasmacytoid Dendritic Cell

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Anatomical Context for Blastic Plasmacytoid Dendritic Cell

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MalaCards organs/tissues related to Blastic Plasmacytoid Dendritic Cell:

33
Myeloid, Skin, Bone marrow, Bone, Lung, B cells, Lymph node, Monocytes, Nk cells, T cells, Endothelial

Animal Models for Blastic Plasmacytoid Dendritic Cell or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Blastic Plasmacytoid Dendritic Cell:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1TET2, MYD88, NPM1, CDKN2A, CDKN1B
2MP:00030129.0TET2, MYD88, CD4, CDKN2A, CDKN1B
3MP:00053708.8TET2, PECAM1, NPM1, CDKN2A, CDKN1B
4MP:00053918.8CDKN1B, CDKN2A, NPM1, NCAM1, MYD88
5MP:00053858.2TET2, PECAM1, MPO, MYD88, NPM1, CDKN1B
6MP:00053788.1TET2, MYD88, NCAM1, NPM1, CD4, CDKN2A
7MP:00053818.1SPIB, PECAM1, MYD88, CD4, CDKN2A, CDKN1B
8MP:00053977.3CDKN1B, TET2, SPIB, PECAM1, MPO, MYD88
9MP:00107687.3TET2, SPIB, MPO, MYD88, NCAM1, NPM1
10MP:00053877.3TET2, SPIB, PECAM1, MPO, MYD88, NPM1
11MP:00053847.2TET2, SPIB, PECAM1, MYD88, NCAM1, NPM1

Publications for Blastic Plasmacytoid Dendritic Cell

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52PubMed
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Articles related to Blastic Plasmacytoid Dendritic Cell:

(show top 50)    (show all 99)
idTitleAuthorsYear
1
Two rare cases of blastic plasmacytoid dendritic cell neoplasm and a literature review. (24432892)
2014
2
CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm. (24142740)
2014
3
Blastic plasmacytoid dendritic cell neoplasm. (23582004)
2013
4
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation. (23203822)
2013
5
L-asparaginase with methotrexate and dexamethasone is an effective treatment combination in blastic plasmacytoid dendritic cell neoplasm. (23937331)
2013
6
Blastic Plasmacytoid Dendritic Cell Neoplasm: Evolving Insights in an Aggressive Hematopoietic Malignancy With a Predilection of Skin Involvement. (24247574)
2013
7
Blastic plasmacytoid dendritic cell neoplasm in an elderly woman. (23629565)
2013
8
Lung involvement at initial presentation in blastic plasmacytoid dendritic cell neoplasm lacking cutaneous lesion. (22933234)
2013
9
Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature. (22455538)
2013
10
Reply to "A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm" and to "A low-grade B-cell lymphoma with prolymphocytic/paraimmunoblastic proliferation and IRF4 rearrangement" dendritic cell leukemia. (23449597)
2013
11
SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms. (23165482)
2013
12
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. (23065521)
2013
13
TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow. (23940084)
2013
14
Sustained complete remission in an elderly patient with a blastic plasmacytoid dendritic cell neoplasm following autologous peripheral blood stem cell transplantation. (23435845)
2013
15
Immunohistochemical analysis of CD123, CD56 and CD4 for the diagnosis of minimal bone marrow involvement by blastic plasmacytoid dendritic cell neoplasm. (23470050)
2013
16
Skin lesions in a patient with blastic plasmacytoid dendritic cell neoplasm. (24372537)
2013
17
Unusual Morphologic Presentations of Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of Two Cases Misdiagnosed as Melanoma and Leprosy. (23515558)
2013
18
Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm? (24312342)
2013
19
A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm. (23300173)
2013
20
Childhood blastic plasmacytoid dendritic cell neoplasm treated with allogenic stem cell transplantation. (22300352)
2013
21
Blastic plasmacytoid dendritic cell neoplasm in a human T-cell lymphotropic virus type I (HTLV-1) carrier: a coincidental association? (23558032)
2013
22
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Rapidly Progressive and Fatal Disease without Aggressive Intervention. (24385715)
2013
23
Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose DeVIC therapy and radiation therapy: a case report and review of the literature. (24228127)
2013
24
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
25
Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry is useful for blastic plasmacytoid dendritic cell leukemia diagnosis. (22674796)
2012
26
Loss of genomic DNA copy numbers in the p18, p16, p27 and RB loci in blastic plasmacytoid dendritic cell neoplasm. (22361914)
2012
27
Blastic plasmacytoid dendritic cell neoplasm in a child. (22583725)
2012
28
Cutaneous blastic plasmacytoid dendritic cell neoplasm occurring after spontaneous remission of acute myeloid leukemia: a case report and review of literature. (22476762)
2012
29
Congenital blastic plasmacytoid dendritic cell neoplasm. (21744480)
2012
30
Excessive therapeutic response in a case of blastic plasmacytoid dendritic cell neoplasm. (22398810)
2012
31
Blastic plasmacytoid dendritic cell neoplasm without cutaneous involvement: a rare disease with a rare presentation. (21871006)
2012
32
Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. (22338048)
2012
33
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review. (21890199)
2012
34
The first case of blastic plasmacytoid dendritic cell neoplasm with MLL-ENL rearrangement. (21831428)
2012
35
Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm. (21835496)
2012
36
Cutaneous accumulation of plasmacytoid dendritic cells associated with acute myeloid leukemia: a rare condition distinct from blastic plasmacytoid dendritic cell neoplasm. (21883371)
2011
37
An unusual case of cutaneous blastic plasmacytoid dendritic cell neoplasm with concomitant B-cell lymphoproliferative disorder. (20861710)
2011
38
Primary cutaneous blastic plasmacytoid dendritic cell neoplasm without extracutaneous manifestation: case report and review of the literature. (20573459)
2011
39
Blastic plasmacytoid dendritic cell neoplasm. (20940186)
2011
40
Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm. (21628861)
2011
41
Blastic plasmacytoid dendritic cell neoplasm on the scalp. (22220144)
2011
42
Lacking CD56 expression in a relapsing cutaneous blastic plasmacytoid dendritic cell neoplasm after allogeneic bone marrow transplantation: FISH analysis revealed loss of 11q. (21923812)
2011
43
Therapeutic effect of lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendritic cell neoplasm. (21856771)
2011
44
Blastic plasmacytoid dendritic cell neoplasm should be treated with acute leukemia type induction chemotherapy and allogeneic stem cell transplantation in first remission. (20697854)
2010
45
Blastic plasmacytoid dendritic cell neoplasm presenting as a subcutaneous mass in an 8-year-old boy. (20552185)
2010
46
Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms. (19924135)
2010
47
A case of blastic plasmacytoid dendritic cell neoplasm initially mimicking cutaneous lupus erythematosus. (21253327)
2010
48
Blastic plasmacytoid dendritic cell neoplasm: is transplantation the treatment of choice? (19689477)
2010
49
Cutaneous blastic plasmacytoid dendritic cell neoplasm associated with anaemia and thrombocytopaenia. (19997703)
2009
50
Philadelphia chromosome-positive blastic plasmacytoid dendritic cell leukemia. (19963123)
2009

Variations for Blastic Plasmacytoid Dendritic Cell

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Expression for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Expression patterns in normal tissues for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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Pathways for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 5Cell Signaling Technology, 55Reactome, 53QIAGEN
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Compounds for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB, 29IUPHAR
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Compounds related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1[alcl]4510.2CDKN1B, NPM1
2hydralazine45 51 1112.1CDKN2A, MPO
3p000014510.0CDKN1B, CDKN2A
45 aminosalicylic acid4510.0PECAM1, MPO
5nickel45 2411.0CD4, CDKN2A
6cytarabine45 51 1111.9CDKN1B, CDKN2A, MPO
7daunorubicin45 51 1111.8CDKN2A, NPM1, MPO
8camptothecin45 61 1111.8CDKN1B, CDKN2A, NPM1
95fluorouracil459.8CDKN1B, CDKN2A, MPO
10rrna459.8CDKN2A, NPM1
11chloramphenicol45 3 51 1112.7CDKN2A, CD4, MPO
12methanol45 2410.7CDKN2A, MPO
13n acetylcysteine459.7CDKN1B, CDKN2A, MPO
14rantes459.7PECAM1, MYD88, CD4
15hematoxylin459.7PECAM1, NCAM1, CDKN2A
16agar459.6PECAM1, CDKN2A, CDKN1B
17butyrate459.6CDKN1B, CDKN2A, MPO
18fatty acid459.6MYD88, NPM1, CDKN2A, CDKN1B
19formaldehyde45 2410.5PECAM1, MPO, CD4, CDKN1B
20paclitaxel45 51 1111.5NPM1, CDKN2A, CDKN1B
21leucine459.5NPM1, CD4, CDKN2A, CDKN1B
22oligonucleotide459.5CDKN1B, CDKN2A, CD4, MYD88
23doxorubicin45 51 1111.5CDKN1B, CDKN2A, NPM1, NCAM1
24progesterone45 29 61 24 1113.5NCAM1, CD4, CDKN2A, CDKN1B
25actinomycin d459.4CDKN1B, CDKN2A, NPM1, PECAM1
26rapamycin459.4CDKN1B, NPM1, PECAM1
27h2o2459.4CDKN1B, CDKN2A, MPO, PECAM1
28cholesterol45 29 24 1112.4PECAM1, CD4, CDKN2A, CDKN1B
2912-o-tetradecanoylphorbol 13-acetate459.3CDKN1B, CD4, NCAM1, IL3RA
30oxygen45 2410.2PECAM1, MPO, MYD88, CDKN2A, CDKN1B
31alanine459.2NCAM1, NPM1, CD4, CDKN2A, CDKN1B
32cycloheximide459.1PECAM1, NPM1, CD4, CDKN2A, CDKN1B
33heparin45 29 24 1112.1PECAM1, MPO, NCAM1, CD4, CDKN1B
34vegf459.0PECAM1, MPO, NCAM1, CDKN2A, CDKN1B
35lipid459.0PECAM1, MYD88, NCAM1, CD4, CDKN2A
36phosphatidylinositol459.0MYD88, IL3RA, NCAM1, CD4, CDKN1B
37estrogen459.0PECAM1, NCAM1, NPM1, CDKN2A, CDKN1B
38histamine45 29 2411.0PECAM1, MPO, NCAM1
39cysteine459.0PECAM1, NCAM1, NPM1, CD4, CDKN2A
40nitric oxide45 24 1110.8PECAM1, MPO, MYD88, NCAM1, CDKN2A, CDKN1B
41atp45 299.8PECAM1, MYD88, NCAM1, NPM1, CDKN2A, CDKN1B
42paraffin458.7PECAM1, MPO, NCAM1, NPM1, CDKN2A, CDKN1B
43retinoic acid45 249.7PECAM1, MPO, NCAM1, NPM1, CDKN2A, CDKN1B
44calcium45 51 24 1111.6PECAM1, MPO, NCAM1, NPM1, CD4, CDKN2A
45serine458.0PECAM1, MPO, MYD88, TCL1A, NCAM1, CD4
46threonine457.3CDKN1B, PECAM1, MYD88, TCL1A, IL3RA, NCAM1
47tyrosine456.9SPIB, PECAM1, MYD88, LILRA4, IL3RA, NCAM1

GO Terms for genes affiliated with Blastic Plasmacytoid Dendritic Cell

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16Gene Ontology
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Biological processes related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:0423269.8CDKN1B, CDKN2A
2negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.5CDKN1B, CDKN2A
3negative regulation of apoptotic processGO:0430669.2CDKN1B, NPM1, MYD88, MPO

Molecular functions related to Blastic Plasmacytoid Dendritic Cell according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.8CDKN1B, CDKN2A
2NF-kappaB bindingGO:0510599.5CDKN2A, NPM1
3protein kinase bindingGO:0199019.5CDKN2A, CD4, NPM1
4protein bindingGO:0055157.1TET2, PECAM1, MYD88, LILRA4, TCL1A, NPM1

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