Aliases & Classifications for Blastoma

Aliases & Descriptions for Blastoma:

Name: Blastoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0070003

Summaries for Blastoma

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from precursor cells called blast cells.

MalaCards based summary : Blastoma is related to pneumothorax and kidney disease. An important gene associated with Blastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are MicroRNAs in cancer and Thyroid cancer. The drugs Temozolomide and Trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include lung, pituitary and thyroid, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 71 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Related Diseases for Blastoma

Diseases related to Blastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
id Related Disease Score Top Affiliating Genes
1 pneumothorax 30.4 DICER1 SYP
2 kidney disease 29.4 NKX2-1 SYP TP53
3 pleuropulmonary blastoma 12.4
4 pulmonary blastoma 12.1
5 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 12.1
6 classic pulmonary blastoma 11.9
7 pleuropulmonary blastoma type 1 11.8
8 epithelial predominant pulmonary blastoma 11.8
9 pleuropulmonary blastoma type 2 11.7
10 pleuropulmonary blastoma type 3 11.7
11 embryoma 11.2
12 dicer1-related disorders 11.0
13 proliferative glomerulonephritis 10.3 DICER1 SYP
14 cervical benign neoplasm 10.3 SYP TP53
15 clear cell meningioma 10.3 SYP TP53
16 perineural angioma 10.3 SYP TP53
17 paternal uniparental disomy of chromosome 1 10.3 SYP TP53
18 nipple neoplasm 10.3 DICER1 SYP
19 blood group incompatibility 10.3 SYP TP53
20 mast-cell sarcoma 10.2 SYP TP53
21 olfactory neuroblastoma 10.2 SYP TP53
22 liver angiosarcoma 10.2 DES DICER1
23 paraphimosis 10.2 SYP TP53
24 pineoblastoma 10.2 SYP TP53
25 fragile x-associated tremor/ataxia syndrome 10.2 SYP TP53
26 gallbladder pleomorphic giant cell adenocarcinoma 10.2 SYP TP53
27 adult epithelioid sarcoma 10.2 SYP TP53
28 brain stem astrocytic neoplasm 10.2 SYP TP53
29 acantholytic squamous cell skin carcinoma 10.2 MB TP53
30 functionless pituitary adenoma 10.2 MB TP53
31 coronary stenosis 10.2 DES TP53
32 male reproductive system disease 10.2 DES SYP
33 hemangioma of liver 10.2 S100B TP53
34 bone benign neoplasm 10.2 SYP TP53
35 choriocarcinoma of ovary 10.2 MB TP53
36 conjunctival cancer 10.2 S100B TP53
37 jejunal neuroendocrine tumor 10.2 S100B SYP
38 house allergic alveolitis 10.2 DES TP53
39 spinal chordoma 10.2 MB SYP
40 microinvasive cervical squamous cell carcinoma 10.2 S100B SYP
41 sebaceous adenoma 10.2 DES SYP
42 corneal intraepithelial neoplasm 10.2 S100B SYP
43 hypoparathyroidism-intellectual disability-dysmorphism syndrome 10.2 S100B SYP
44 brain oligodendroglioma 10.2 SYP TP53
45 central nervous system mature teratoma 10.2 S100B TP53
46 adenofibroma 10.2 S100B SYP
47 behcet's syndrome arthropathy 10.2 S100B SYP
48 monkeypox 10.2 S100B SYP
49 aneurysm of sinus of valsalva 10.2 S100B SYP
50 thymus squamous cell carcinoma 10.2 SYP TP53

Graphical network of the top 20 diseases related to Blastoma:



Diseases related to Blastoma

Symptoms & Phenotypes for Blastoma

MGI Mouse Phenotypes related to Blastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 SYP TP53 DES DICER1 KRAS NKX2-1
2 cardiovascular system MP:0005385 9.73 DES DICER1 KRAS MB NKX2-1 TP53
3 homeostasis/metabolism MP:0005376 9.7 DES DICER1 KRAS MB NKX2-1 S100B
4 normal MP:0002873 9.43 DICER1 KRAS NKX2-1 S100B SYP TP53
5 respiratory system MP:0005388 9.02 DICER1 KRAS MB NKX2-1 TP53

Drugs & Therapeutics for Blastoma

Drugs for Blastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3 Alkylating Agents Phase 2
4 Antineoplastic Agents, Alkylating Phase 2
5 Antimitotic Agents Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Ado-trastuzumab emtansine Phase 2
8 Immunoglobulins Phase 2
9 Antibodies, Monoclonal Phase 2
10 Maytansine Phase 2
11 Antibodies Phase 2
12
Doxorubicin Approved, Investigational 23214-92-8 31703
13
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
14
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
15
Ifosfamide Approved 3778-73-2 3690
16
Mechlorethamine Approved 51-75-2 4033
17
Dactinomycin Approved 50-76-0 2019 457193
18
Doxil Approved June 1999 31703
19 Topoisomerase Inhibitors
20 Nucleic Acid Synthesis Inhibitors
21 Anti-Bacterial Agents
22 Anti-Infective Agents
23 Immunosuppressive Agents
24 Isophosphamide mustard
25 Antibiotics, Antitubercular
26 Antirheumatic Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606
6 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
9 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769

Search NIH Clinical Center for Blastoma

Genetic Tests for Blastoma

Anatomical Context for Blastoma

MalaCards organs/tissues related to Blastoma:

39
Lung, Pituitary, Thyroid, Fetal Lung, Kidney, Brain, Ovary

Publications for Blastoma

Articles related to Blastoma:

(show top 50) (show all 403)
id Title Authors Year
1
It's Rare So Be Aware: Pleuropulmonary Blastoma Mimicking Congenital Pulmonary Airway Malformation. ( 28405541 )
2017
2
Type III pleuropulmonary blastoma in a dicer1 germline mutation carrier: The management of residual lung cystic lesions. ( 28097783 )
2017
3
A Case Report of Pleuropulmonary Blastoma Presenting as Tension Pneumothorax. ( 28469342 )
2017
4
Fine needle aspiration in intraocular metastasis from pleuropulmonary blastoma. A case report and a review of the literature. ( 27718333 )
2017
5
Synthesis of silica-PAMAM dendrimer nanoparticles as promising carriers in Neuro blastoma cells. ( 27939389 )
2017
6
The impact of local control in the treatment of type II/III pleuropulmonary blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS). ( 28103635 )
2017
7
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree. ( 28222777 )
2017
8
A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma. ( 27877056 )
2016
9
Reply to the Letter to the Editor 'Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV'. ( 27577236 )
2016
10
Metachronous Type I pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child. ( 27442759 )
2016
11
Pathomechanisms of Congenital Cystic Lung Diseases: Focus on Congenital Cystic Adenomatoid Malformation and Pleuropulmonary Blastoma. ( 26907828 )
2016
12
DICER1-Negative Pleuropulmonary Blastoma in a Patient With Selective IgA Deficiency. ( 26686196 )
2016
13
Reply to comment on: DICER1-negative pleuropulmonary blastoma in a patient with selective IgA deficiency. ( 27443584 )
2016
14
Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV. ( 27562209 )
2016
15
Comment on: DICER1-Negative Pleuropulmonary Blastoma in a Patient With Selective IgA Deficiency. ( 27238822 )
2016
16
Biphasic Pulmonary Blastoma Associated with Cerebral Metastasis. ( 26768884 )
2016
17
Giant pleuropulmonary blastoma. ( 27341849 )
2016
18
Somatic DICER1 mutations in adult-onset pulmonary blastoma. ( 27126690 )
2016
19
Rhabdoid Tumor Predisposition Syndrome and Pleuropulmonary Blastoma Syndrome. ( 27617153 )
2016
20
What do we know about pulmonary blastoma?: review of literature and clinical case report. ( 28008207 )
2016
21
Somatic DICER1 gene mutation in sporadic intraocular medulloepithelioma without pleuropulmonary blastoma syndrome. ( 25791583 )
2015
22
Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. ( 25500911 )
2015
23
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know. ( 26454454 )
2015
24
Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia. ( 27532029 )
2015
25
Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature. ( 25755806 )
2015
26
Pleuropulmonary blastoma: a case report. ( 25560611 )
2015
27
Pleuropulmonary Blastoma in a Neonate Diagnosed Prenatally as Congenital Pulmonary Airway Malformation. ( 26227654 )
2015
28
Infant pleuropulmonary blastoma: report of a rare case and review of literature. ( 26722577 )
2015
29
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma. ( 25978641 )
2015
30
Pleuropulmonary blastoma in adolescence: A rare tumor beyond first decade of life. ( 25983419 )
2015
31
Can congenital pulmonary airway malformation be distinguished from Type I pleuropulmonary blastoma based on clinical and radiological features? ( 26561249 )
2015
32
Radiographic Screening of Infants and Young Children With Genetic Predisposition for Rare Malignancies: DICER1 Mutations and Pleuropulmonary Blastoma. ( 25794098 )
2015
33
A Rare Case of Childhood Stiff Person Syndrome Associated With Pleuropulmonary Blastoma. ( 26344328 )
2015
34
Neoadjuvant Chemoradiotherapy Treatment for a Classic Biphasic Pulmonary Blastoma with High PD-L1 Expression. ( 26254381 )
2015
35
Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. ( 26056800 )
2015
36
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. ( 26698637 )
2015
37
Unresectable Middle Mediastinal Biphasic Pulmonary Blastoma. ( 26504071 )
2015
38
A Case of Biphasic Pulmonary Blastoma Treated with Carboplatin and Paclitaxel plus Bevacizumab. ( 26075125 )
2015
39
Radiologic diagnosis of a type-III pleuropulmonary blastoma. ( 25786292 )
2014
40
Ciliary body medulloepithelioma association with pleuropulmonary blastoma in a familial tumor predisposition syndrome. ( 25032694 )
2014
41
Type III pleuropulmonary blastoma in a 7-month-old female baby with impending respiratory failure: a case report. ( 24958022 )
2014
42
Pulmonary blastoma: a case report and review of the literature. ( 24885892 )
2014
43
Pleuropulmonary blastoma type III extended into the left atrium in a 16-month old boy. ( 24599167 )
2014
44
Germline and somatic DICER1 mutations in a pituitary blastoma causing infantile-onset Cushing's disease. ( 24823459 )
2014
45
Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma. ( 24675358 )
2014
46
Surgery and radiation therapy for brain metastases from classic biphasic pulmonary blastoma. ( 24895392 )
2014
47
Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations. ( 24839956 )
2014
48
Treatment and prognostic factors in pleuropulmonary blastoma: An EXPeRT report. ( 24041875 )
2014
49
Nasal chondromesenchymal hamartoma in an adolescent with pleuropulmonary blastoma. ( 25129191 )
2014
50
Case 211: Pleuropulmonary Blastoma in Association with Cystic Nephroma-DICER1 Syndrome. ( 25340273 )
2014

Variations for Blastoma

Expression for Blastoma

Search GEO for disease gene expression data for Blastoma.

Pathways for Blastoma

Pathways related to Blastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 DICER1 KRAS TP53
2 10.09 KRAS TP53

GO Terms for Blastoma

Biological processes related to Blastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 9.16 S100B SYP
2 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 KRAS SYP
3 epithelial tube branching involved in lung morphogenesis GO:0060441 8.62 KRAS NKX2-1

Molecular functions related to Blastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 DES S100B SYP TP53

Sources for Blastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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