MCID: BLS003
MIFTS: 50

Blastoma malady

Summaries for Blastoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from precursor cells called blast cells.

MalaCards: Blastoma is related to pulmonary blastoma and pleuropulmonary blastoma. An important gene associated with Blastoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds vincristine and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and thyroid, and related mouse phenotypes are muscle and nervous system.

Wikipedia:63 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Aliases & Classifications for Blastoma

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

blastoma 8 42 60


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Disease Ontology8 DOID:0070003

Related Diseases for Blastoma

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17GeneCards, 18GeneDecks
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Diseases related to Blastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary blastoma31.5NKX2-1
2pleuropulmonary blastoma31.5TARBP2, DICER1, XPO5
3cystic nephroma30.5DICER1
4thyroid cancer30.0TP53, NKX2-1
5adenocarcinoma30.0EGFR, VIM, CTNNB1, MYCN, NKX2-1, CGB
6hemangioma29.8NKX2-1
7neurofibromatosis29.8KRAS
8pancreatitis29.8SERPINA1, KRAS
9rhabdomyosarcoma29.8VIM, MYCN, TP53
10retinoblastoma29.8EGFR, TP53, KRAS, MYCN, SYP
11lung adenocarcinoma29.8SERPINA1, TP53, KRAS, EGFR, NKX2-1, CTNNB1
12sarcoma29.8CGB, ATF1, MYCN, WNT1, TP53, KRAS
13melanoma29.8TP53, CGB, KRAS, CTNNB1, BIRC7, NKX2-1
14classic pulmonary blastoma10.4
15dicer1-related pleuropulmonary blastoma cancer predisposition syndrome10.4
16pneumothorax10.3
17embryoma10.2
18thyroiditis10.2
19cerebritis10.1
20epithelial predominant pulmonary blastoma10.1
21medulloepithelioma10.1
22spindle cell carcinoma10.0
23laryngitis10.0
24pleuropulmonary blastoma type 110.0
25pleuropulmonary blastoma type 210.0
26pleuropulmonary blastoma type 310.0
27thymoma10.0NKX2-1
28biliary tract neoplasm10.0EGFR
29adrenocortical carcinoma10.0TP53
30giant cell glioblastoma10.0EGFR
31gastrointestinal stromal tumor10.0VIM
32hemangioblastoma10.0SYP
33craniopharyngioma10.0CTNNB1
34subependymal giant cell astrocytoma10.0SYP
35leiomyoma10.0VIM
36angiomyolipoma10.0VIM
37gastritis10.0TP53
38paraganglioma10.0SYP
39malignant mesothelioma10.0NKX2-1, VIM
40cystadenoma10.0KRAS
41nephroblastoma10.0TP53, CTNNB1
42myelodysplastic syndromes10.0KRAS
43merkel cell carcinoma10.0NKX2-1, SYP
44pituitary tumors10.0POU1F1
45thymus cancer10.0SYP, NKX2-1
46esophageal cancer10.0EGFR, TP53
47teratoma10.0NKX2-1, CGB
48rhabdoid tumor10.0VIM, SYP
49pituitary adenoma10.0POU1F1, SYP
50mental retardation10.0DCX

Graphical network of the top 20 diseases related to Blastoma:



Diseases related to blastoma

Clinical Features for Blastoma

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Drugs & Therapeutics for Blastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Blastoma

Drug clinical trials:

Search ClinicalTrials for Blastoma

Search NIH Clinical Center for Blastoma

Search CenterWatch for Blastoma

Genetic Tests for Blastoma

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Anatomical Context for Blastoma

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32MalaCards
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MalaCards organs/tissues related to Blastoma:

32
Lung, Fetal lung, Thyroid, Kidney, Pituitary, Lymph node, Ovary, Liver, Spinal cord, Brain, Bronchial epithelium

Animal Models for Blastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Blastoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.5MYCN, TP53
2MP:000363110.4POU1F1, SYP, DCX, NKX2-1, DICER1
3MP:000538810.3CTNNB1, DICER1, EGFR, MYCN, KRAS, TP53
4MP:000537910.3TP53, KRAS, POU1F1
5MP:000539010.2NKX2-1, MYCN, WNT1
6MP:000200610.2CTNNB1, DICER1, EGFR, NKX2-1, KRAS, TP53
7MP:000301210.1CTNNB1, EGFR, NKX2-1, DCX, SYP, MYCN
8MP:000538210.1CTNNB1, DICER1, EGFR, POU1F1, MYCN, WNT1
9MP:000538910.0CTNNB1, EGFR, DCX, POU1F1, MYCN, TARBP2
10MP:000287310.0CTNNB1, DICER1, EGFR, ATF1, SYP, MYCN
11MP:000538010.0VIM, CTNNB1, DICER1, EGFR, ATF1, MYCN
12MP:00053679.9DICER1, EGFR, MYCN
13MP:00053859.9VIM, CTNNB1, DICER1, EGFR, NKX2-1, MYCN
14MP:00053709.9TP53, KRAS, MYCN, EGFR, DICER1, CTNNB1
15MP:00053869.9VIM, CTNNB1, DICER1, NKX2-1, DCX, MYCN
16MP:00053849.8VIM, CTNNB1, DICER1, EGFR, ATF1, NKX2-1
17MP:00053879.8VIM, CTNNB1, DICER1, EGFR, ATF1, POU1F1
18MP:00053789.8VIM, CTNNB1, DICER1, EGFR, NKX2-1, DCX
19MP:00053979.8TP53, KRAS, WNT1, MYCN, POU1F1, EGFR
20MP:00107689.6VIM, CTNNB1, DICER1, EGFR, ATF1, NKX2-1

Publications for Blastoma

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50PubMed
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Articles related to Blastoma:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Treatment and prognostic factors in pleuropulmonary blastoma: An EXPeRT report. (24041875)
2014
2
18F-FDG PET/CT appearances of adult pulmonary blastoma. (23751833)
2013
3
Pleuropulmonary Blastoma: A Case Report. (24101356)
2013
4
Pulmonary blastoma: a rare primary lung malignancy. (23049565)
2012
5
Pulmonary blastoma in a young adult. (23008928)
2012
6
Pleuropulmonary blastoma presenting as a complicated pleural effusion. (21466054)
2011
7
Pulmonary blastoma with yolk sac elements. (21045461)
2010
8
A rare association; pulmonary blastoma developing on extrapulmonary sequestration basis. (20395246)
2010
9
Fetal lung interstitial tumor (FLIT): A proposed newly recognized lung tumor of infancy to be differentiated from cystic pleuropulmonary blastoma and other developmental pulmonary lesions. (21107081)
2010
10
Pleuropulmonary blastoma in an infant. (19904509)
2009
11
DICER1 mutations in familial pleuropulmonary blastoma. (19556464)
2009
12
A familial case of pleuropulmonary blastoma. (18493897)
2008
13
Pediatric thyroid cancer arising as a fourth cancer in a child with pleuropulmonary blastoma. (18000857)
2008
14
Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry. (18223332)
2008
15
Pleuropulmonary blastoma, a distinctive neoplasm of childhood: report of three cases. (17285284)
2007
16
Pulmonary blastoma. (17686364)
2007
17
Solitary brain metastasis from classic biphasic pulmonary blastoma: a case report and review of the literature. (17202827)
2006
18
Pulmonary blastoma--a rare tumor with variable presentation. (16387506)
2006
19
A rare case of classic biphasic pulmonary blastoma. (16447486)
2005
20
Pulmonary blastoma. (16363721)
2005
21
Thyroid transcription factor-1 expression in pulmonary blastoma. (15140003)
2004
22
Pleuropulmonary blastoma in the area of a previously diagnosed congenital lung cyst: report of two cases. (15239424)
2004
23
Expression of KIT (CD117) in biphasic pulmonary blastoma. Novel data on histogenesis. (14692559)
2003
24
Pleuropulmonary blastoma in a young adult presenting as a ruptured cystic teratoma in radiology. (12923341)
2003
25
Pleuropulmonary blastoma with a large embolic cerebral infarct. (12712268)
2003
26
Pulmonary blastoma: case report in an adult. (12814050)
2002
27
Pulmonary blastoma: report of a case. (10483763)
1999
28
Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis. (9648976)
1998
29
Case of extra pulmonary, pleuro-pulmonary blastoma in a child: pathological and cytogenetic findings. (9142208)
1997
30
Pulmonary blastoma with fatal hypercalcemia. (9154681)
1997
31
Pleuropulmonary blastoma of the lung presenting as posterior mediastinal mass: a case report. (9267881)
1997
32
p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas. (8666362)
1996
33
Pulmonary blastoma: a review with special emphasis on prognosis and treatment. (8841388)
1996
34
Case of the season. Pulmonary blastoma. (7570076)
1995
35
Pleuropulmonary blastoma (pulmonary blastoma of childhood): genetic link with other embryonal malignancies? (8063284)
1994
36
Radiological case of the month. Pulmonary blastoma. (8488810)
1993
37
Pulmonary blastoma. Comparison between its epithelial components and fetal bronchial epithelium. (1290326)
1992
38
Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases. (1722041)
1991
39
Diagnosis of pulmonary blastoma by fine-needle aspiration biopsy: cytologic and immunocytochemical findings. (1709089)
1991
40
Pulmonary blastoma with rhabdomyosarcomatous differentiation: an electron microscopic and immunohistochemical study. (3337338)
1988
41
Six cases of well-differentiated adenocarcinoma simulating fetal lung tubules in pseudoglandular stage. Comparison with pulmonary blastoma. (6496842)
1984
42
Pulmonary blastoma: remission with chemotherapy. (6086368)
1984
43
Pulmonary blastoma in children. Two case reports and a review of the literature. (6828711)
1983
44
Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung). (6179430)
1982
45
Nasal blastoma. (6267759)
1981
46
Chromosome analysis in a human hepato-blastoma cell line producing alpha-fetoprotein. (6161524)
1980
47
Cytopathologic findings in pulmonary blastoma. (295162)
1979
48
Pulmonary blastoma in a child. (177747)
1976
49
Pulmonary blastoma (embryoma lung). A case report with review of literature. (1193668)
1975
50
Roentgen manifestations of pulmonary blastoma. (5041154)
1972

Genetic Variations for Blastoma

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Expression for genes affiliated with Blastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blastoma

Search GEO for disease gene expression data for Blastoma.

Pathways for genes affiliated with Blastoma

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Sources:
51QIAGEN, 59Tocris Bioscience, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Blastoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4EGFR
2
Hide members
10.3KRAS, CTNNB1
3
Hide members
10.3KRAS, TP53
410.3DICER1, TARBP2
510.2TP53, KRAS, CTNNB1
610.2TP53, EGFR, CTNNB1
710.2CTNNB1, EGFR, TP53
810.2CTNNB1, EGFR, TP53
9
Hide members
10.2EGFR, KRAS, TP53
1010.2TP53, KRAS, EGFR
11
Hide members
10.2TARBP2, XPO5, DICER1
12
Transcription Androgen Receptor nuclear signaling
Hide members
10.2WNT1, EGFR, CTNNB1
13
Hide members
10.1CTNNB1, EGFR, KRAS, TP53
1410.1TP53, KRAS, EGFR, CTNNB1
15
Hide members
10.1CTNNB1, EGFR, KRAS, TP53
1610.1NKX2-1, DCX, SYP, MYCN
17
Hide members
10.1TP53, KRAS, WNT1, CTNNB1
1810.1VIM, CTNNB1, WNT1, TP53
1910.0TP53, KRAS, EGFR, DICER1, VIM
2010.0CTNNB1, EGFR, WNT1, KRAS, TP53
2110.0TP53, KRAS, ATF1, EGFR, CTNNB1
2210.0CTNNB1, ATF1, WNT1, KRAS, TP53
239.9CTNNB1, EGFR, WNT1, BIRC7, KRAS, TP53

Compounds for genes affiliated with Blastoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Blastoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.7MYCN, VIM
2mucicarmine4410.7VIM, NKX2-1, SYP
3cycloheximide4410.6MYCN
4b 7234410.6VIM, NKX2-1, SYP
5temozolomide44 1111.6TP53, EGFR, VIM
6panitumumab44 49 1112.6KRAS, EGFR
7crcs4410.6CTNNB1, KRAS, TP53
8cetuximab44 49 1112.6KRAS, EGFR, CTNNB1
9roscovitine4410.6VIM, CTNNB1, TP53
10leucovorin44 49 1112.5KRAS, CGB, EGFR
11gefitinib44 49 1112.5VIM, CTNNB1, EGFR, KRAS
12adriamycin4410.5TP53, MYCN, CTNNB1, VIM
13paclitaxel44 49 1112.5CTNNB1, EGFR, KRAS, TP53
14s 1004410.5SYP, VIM
15etoposide44 49 59 1113.5VIM, CGB, MYCN, BIRC7
16oxaliplatin44 49 1112.5TP53, KRAS, EGFR
17hematoxylin4410.5SYP, NKX2-1, VIM
18mg 13244 5911.5CTNNB1, EGFR, MYCN, TP53
194-hydroxytamoxifen4410.5VIM, CTNNB1, EGFR
20bromodeoxyuridine4410.5MYCN, DCX, CTNNB1, VIM
21lithium44 49 11 2413.5WNT1, SYP, CTNNB1
22retinoid4410.5VIM, CTNNB1, EGFR, MYCN, TP53
23gnrh4410.5VIM, CTNNB1, CGB, NKX2-1
24agar4410.4WNT1, MYCN, EGFR, CTNNB1, VIM
255fluorouracil4410.4TP53, KRAS, BIRC7, EGFR, CTNNB1
26sb 20358044 5911.4VIM, CTNNB1, EGFR, ATF1, TP53
27irinotecan44 49 1112.4EGFR, KRAS, TP53
28dbc-amp4410.4MYCN, SYP, VIM
29bleomycin44 1111.4CTNNB1, CGB, TP53
30genistein44 28 59 2 11 2415.4VIM, CTNNB1, EGFR, SYP, MYCN
31forskolin44 49 1112.4POU1F1, SYP, NKX2-1, ATF1, VIM
32doxorubicin44 49 1112.4VIM, CTNNB1, EGFR, MYCN, BIRC7, TP53
33h2o24410.3VIM, CTNNB1, SYP, KRAS, SERPINA1, TP53
34cyclic amp44 2411.3VIM, CGB, ATF1, NKX2-1, SYP, POU1F1
35phosphoinositide4410.3VIM, CTNNB1, EGFR, ATF1, POU1F1, KRAS
36leucine4410.3VIM, ATF1, SYP, POU1F1, MYCN
37tamoxifen44 49 28 1113.2TP53, EGFR, CTNNB1, VIM
38adpribose4410.2TP53, EGFR, CTNNB1
39cisplatin44 49 59 1113.2CTNNB1, EGFR, CGB, SYP, MYCN, BIRC7
40vitamin d4410.2VIM, CTNNB1, POU1F1, KRAS
41paraffin4410.2VIM, CTNNB1, EGFR, NKX2-1, SYP, MYCN
42geldanamycin44 49 59 1113.1TP53, EGFR, CTNNB1
43vegf4410.1VIM, CTNNB1, EGFR, CGB, DCX, SYP
44tyrosine4410.1CTNNB1, EGFR, NKX2-1, SYP, POU1F1, MYCN
45testosterone44 59 11 2413.0SYP, CGB, EGFR, CTNNB1, VIM
46retinoic acid44 2411.0VIM, CTNNB1, EGFR, NKX2-1, SYP, POU1F1
47oligonucleotide4410.0VIM, CTNNB1, ATF1, NKX2-1, POU1F1, MYCN
48progesterone44 59 28 11 2413.9TP53, VIM, CTNNB1, EGFR, CGB, ATF1
49nocodazole44 1110.9VIM, CTNNB1, TP53
50serine449.8NKX2-1, ATF1, EGFR, CTNNB1, VIM, DCX

GO Terms for genes affiliated with Blastoma

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16Gene Ontology
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Cellular components related to Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RISC complexGO:01644210.0TARBP2, DICER1
2nucleoplasmGO:0056549.9TP53, TTF1, NKX2-1, ATF1, XPO5, CTNNB1

Biological processes related to Blastoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.6WNT1, CTNNB1
2production of siRNA involved in RNA interferenceGO:03042210.5TARBP2, DICER1
3targeting of mRNA for destruction involved in RNA interferenceGO:03042310.5TARBP2, DICER1
4pre-miRNA processingGO:03105410.5DICER1, TARBP2
5T cell differentiation in thymusGO:03307710.5CTNNB1, WNT1, TP53
6embryonic axis specificationGO:00057810.4WNT1, CTNNB1
7negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.4TP53, WNT1, NKX2-1
8cerebral cortex cell migrationGO:02179510.4NKX2-1, EGFR
9positive regulation of transcription, DNA-dependentGO:04589310.2CTNNB1, NKX2-1, POU1F1, WNT1, TP53
10neuron migrationGO:00176410.2DCX, NKX2-1, CTNNB1
11determination of adult lifespanGO:00834010.2POU1F1, TP53
12positive regulation of protein phosphorylationGO:00193410.2KRAS, WNT1, EGFR
13positive regulation of transcription from RNA polymerase II promoterGO:04594410.2TP53, CTNNB1, DICER1, EGFR, NKX2-1, POU1F1
14negative regulation of transcription from RNA polymerase II promoterGO:00012210.1CTNNB1, DICER1, NKX2-1, POU1F1, TP53
15epithelial tube branching involved in lung morphogenesisGO:06044110.0NKX2-1, CTNNB1

Molecular functions related to Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:04421210.2CTNNB1, NKX2-1, WNT1, TP53
2chromatin bindingGO:00368210.1TP53, TTF1, POU1F1, EGFR, CTNNB1
3sequence-specific DNA binding transcription factor activityGO:00370010.0ATF1, NKX2-1, POU1F1, MYCN, TP53, CTNNB1
4identical protein bindingGO:0428029.9VIM, EGFR, SYP, SERPINA1, TP53
5enzyme bindingGO:0198999.8TP53, BIRC7, EGFR, CTNNB1
6protein bindingGO:0055159.3VIM, CTNNB1, DICER1, XPO5, EGFR, ATF1

Products for genes affiliated with Blastoma

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Sources for Blastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet