MCID: BLS003
MIFTS: 50

Blastoma malady

Summaries for Blastoma

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A cell type cancer that has material basis in abnormally proliferating cells derived from precursor cells called blast cells.

MalaCards: Blastoma is related to pulmonary blastoma and pleuropulmonary blastoma. An important gene associated with Blastoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds vincristine and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and thyroid, and related mouse phenotypes are muscle and nervous system.

Wikipedia:63 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Aliases & Classifications for Blastoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS
See all sources

Aliases & Descriptions:

blastoma 8 42 60


External Ids:

Disease Ontology8 DOID:0070003

Related Diseases for Blastoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Blastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary blastoma31.5NKX2-1
2pleuropulmonary blastoma31.5TARBP2, DICER1, XPO5
3cystic nephroma30.5DICER1
4thyroid cancer30.0TP53, NKX2-1
5adenocarcinoma30.0EGFR, VIM, CTNNB1, MYCN, NKX2-1, CGB
6hemangioma29.8NKX2-1
7neurofibromatosis29.8KRAS
8pancreatitis29.8SERPINA1, KRAS
9rhabdomyosarcoma29.8VIM, MYCN, TP53
10retinoblastoma29.8EGFR, TP53, KRAS, MYCN, SYP
11lung adenocarcinoma29.8SERPINA1, TP53, KRAS, EGFR, NKX2-1, CTNNB1
12sarcoma29.8CGB, ATF1, MYCN, WNT1, TP53, KRAS
13melanoma29.8TP53, CGB, KRAS, CTNNB1, BIRC7, NKX2-1
14classic pulmonary blastoma10.4
15dicer1-related pleuropulmonary blastoma cancer predisposition syndrome10.4
16pneumothorax10.3
17embryoma10.2
18thyroiditis10.2
19cerebritis10.1
20epithelial predominant pulmonary blastoma10.1
21medulloepithelioma10.1
22spindle cell carcinoma10.0
23laryngitis10.0
24pleuropulmonary blastoma type 110.0
25pleuropulmonary blastoma type 210.0
26pleuropulmonary blastoma type 310.0
27thymoma10.0NKX2-1
28biliary tract neoplasm10.0EGFR
29adrenocortical carcinoma10.0TP53
30giant cell glioblastoma10.0EGFR
31gastrointestinal stromal tumor10.0VIM
32hemangioblastoma10.0SYP
33craniopharyngioma10.0CTNNB1
34subependymal giant cell astrocytoma10.0SYP
35leiomyoma10.0VIM
36angiomyolipoma10.0VIM
37gastritis10.0TP53
38paraganglioma10.0SYP
39malignant mesothelioma10.0NKX2-1, VIM
40cystadenoma10.0KRAS
41nephroblastoma10.0TP53, CTNNB1
42myelodysplastic syndromes10.0KRAS
43merkel cell carcinoma10.0NKX2-1, SYP
44pituitary tumors10.0POU1F1
45thymus cancer10.0SYP, NKX2-1
46esophageal cancer10.0EGFR, TP53
47teratoma10.0NKX2-1, CGB
48rhabdoid tumor10.0VIM, SYP
49pituitary adenoma10.0POU1F1, SYP
50mental retardation10.0DCX

Graphical network of the top 20 diseases related to Blastoma:



Diseases related to blastoma

Clinical Features for Blastoma

About this section

Drugs & Therapeutics for Blastoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Blastoma

Drug clinical trials:

Search ClinicalTrials for Blastoma

Search NIH Clinical Center for Blastoma

Search CenterWatch for Blastoma

Genetic Tests for Blastoma

About this section

Anatomical Context for Blastoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Blastoma:

32
Lung, Fetal lung, Thyroid, Kidney, Pituitary, Lymph node, Ovary, Brain, Bronchial epithelium, Spinal cord, Liver

Animal Models for Blastoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Blastoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.5MYCN, TP53
2MP:000363110.4POU1F1, SYP, DCX, NKX2-1, DICER1
3MP:000538810.3CTNNB1, DICER1, EGFR, MYCN, KRAS, TP53
4MP:000537910.3TP53, KRAS, POU1F1
5MP:000539010.2NKX2-1, MYCN, WNT1
6MP:000200610.2CTNNB1, DICER1, EGFR, NKX2-1, KRAS, TP53
7MP:000301210.1CTNNB1, EGFR, NKX2-1, DCX, SYP, MYCN
8MP:000538210.1CTNNB1, DICER1, EGFR, POU1F1, MYCN, WNT1
9MP:000538910.0CTNNB1, EGFR, DCX, POU1F1, MYCN, TARBP2
10MP:000287310.0CTNNB1, DICER1, EGFR, ATF1, SYP, MYCN
11MP:000538010.0VIM, CTNNB1, DICER1, EGFR, ATF1, MYCN
12MP:00053679.9DICER1, EGFR, MYCN
13MP:00053859.9VIM, CTNNB1, DICER1, EGFR, NKX2-1, MYCN
14MP:00053709.9TP53, KRAS, MYCN, EGFR, DICER1, CTNNB1
15MP:00053869.9VIM, CTNNB1, DICER1, NKX2-1, DCX, MYCN
16MP:00053849.8VIM, CTNNB1, DICER1, EGFR, ATF1, NKX2-1
17MP:00053879.8VIM, CTNNB1, DICER1, EGFR, ATF1, POU1F1
18MP:00053789.8VIM, CTNNB1, DICER1, EGFR, NKX2-1, DCX
19MP:00053979.8TP53, KRAS, WNT1, MYCN, POU1F1, EGFR
20MP:00107689.6VIM, CTNNB1, DICER1, EGFR, ATF1, NKX2-1

Publications for Blastoma

About this section
Sources:
50PubMed
See all sources

Articles related to Blastoma:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Clinicopathological and Extensive Immunohistochemical Study of a Type II Pleuropulmonary Blastoma. (24079261)
2014
2
Classic Biphasic Pulmonary Blastoma Demonstrated by 18F-FDG PET/CT. (23989445)
2013
3
Pulmonary blastoma with submandibular, scrotum and adrenal metastases: case report. (21447935)
2012
4
Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma. (22001215)
2012
5
Expression and mutation analysis of EGFR, c-KIT, and I^-catenin in pulmonary blastoma. (21292787)
2011
6
Establishment and phenotypic characterization of the first human pulmonary blastoma cell line. (20724021)
2011
7
Correction: Pleuropulmonary blastoma, not rhabdomyosarcoma in a congenital lung cyst. (16856157)
2007
8
Biphagic pulmonary blastoma with a lesion of yolk sac tumor. (17642278)
2007
9
Pulmonary blastoma: treatment through sleeve resection of the right upper lobe. (17273572)
2006
10
Familial association of pleuropulmonary blastoma with cystic nephroma and other renal tumors: a report from the International Pleuropulmonary Blastoma Registry. (17137906)
2006
11
Type II pleuropulmonary blastoma responsive to multimodal therapy. (15770834)
2005
12
Case report: pulmonary blastoma: presentation of two atypical cases and review of the literature. (15845939)
2005
13
Imaging findings in pleuropulmonary blastoma. (15657793)
2005
14
Pleuropulmonary blastoma--a rare pathology. (16295472)
2004
15
Clinical-pathologic conference in general thoracic surgery: pulmonary blastoma. (14665988)
2003
16
P53 gene mutations in pleuropulmonary blastomas. (11881786)
2002
17
Unexpected response of a pulmonary blastoma on radiotherapy: a case report and review of the literature. (11955657)
2002
18
Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease. (12414034)
2002
19
Pulmonary blastoma. (11563261)
2001
20
Pleuropulmonary blastoma: four cases. (11149404)
2000
21
Bilateral cystic pleuropulmonary blastoma in early infancy. (10839886)
2000
22
Pleuropulmonary blastoma in an adult: an initial case report. (10357407)
1999
23
Pulmonary blastoma: diagnostic and therapeutic aspects. (10415291)
1999
24
Pulmonary blastoma: report of a case. (10211577)
1999
25
Pleuropulmonary blastoma: survival after intraocular recurrence. (10573587)
1999
26
Pleuropulmonary blastoma: diagnosis by fine-needle aspiration cytology: a case report. (9784998)
1998
27
Pulmonary blastoma. (9255019)
1997
28
Radiological case of the month. Congenital cystic adenomatoid malformation of the lung and pulmonary blastoma. (9343020)
1997
29
Uncertain role of high dose chemotherapy with autologous stem cell support in pediatric pleuro-pulmonary blastoma (PPB) (8950342)
1997
30
Resection and adjuvant chemotherapy of pulmonary blastoma. A case report. (8697409)
1996
31
Case report: pulmonary blastoma in children--response to chemotherapy. (8544803)
1996
32
Resection and adjuvant chemotherapy of pulmonary blastoma: a case report. (8635054)
1995
33
Familial cystic nephroma and pleuropulmonary blastoma. (8382107)
1993
34
Pulmonary blastoma: a rare case of childhood malignancy. (1323822)
1992
35
Pulmonary blastoma--a rare tumour. (1333313)
1992
36
Adrenocortical blastoma. (1398649)
1992
37
Pulmonary blastoma with a topographic transition from blastic to more differentiated areas. An immunohistochemical assessment of its embryonic nature using stage-specific embryonic antigens. (1661048)
1991
38
Pulmonary blastoma: a rare childhood malignancy. (1851314)
1991
39
Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies. (2124206)
1990
40
Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood. (3048630)
1988
41
Pulmonary blastoma, carcinosarcoma and spindle-cell carcinoma: an immunohistochemical study of keratin intermediate filaments. (2418184)
1985
42
Pulmonary blastoma. Case report and literature review of chemotherapy experience. (6370414)
1984
43
Congenital mesonephric blastoma. (6301131)
1983
44
Pulmonary blastoma. (6287397)
1982
45
Pulmonary blastoma. A clinico-pathological study of eleven cases. (7386208)
1980
46
Pulmonary blastoma. (158135)
1979
47
Pulmonary blastoma. (941110)
1976
48
Pulmonary blastoma. A case report and review of the literature. (4811746)
1974
49
Pulmonary blastoma. (5571477)
1971
50
Pulmonary blastoma. A case report and review of the literature. (4908339)
1970

Genetic Variations for Blastoma

About this section

Expression for genes affiliated with Blastoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Blastoma

Search GEO for disease gene expression data for Blastoma.

Pathways for genes affiliated with Blastoma

About this section
Sources:
51QIAGEN, 59Tocris Bioscience, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Blastoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4EGFR
2
Hide members
10.3CTNNB1, KRAS
3
Hide members
10.3TP53, KRAS
410.3TARBP2, DICER1
510.2KRAS, CTNNB1, TP53
610.2EGFR, CTNNB1, TP53
710.2TP53, EGFR, CTNNB1
810.2TP53, EGFR, CTNNB1
910.2KRAS, EGFR, TP53
10
Hide members
10.2TP53, EGFR, KRAS
11
Hide members
10.2DICER1, TARBP2, XPO5
12
Transcription Androgen Receptor nuclear signaling
Hide members
10.2EGFR, WNT1, CTNNB1
1310.1TP53, EGFR, CTNNB1, KRAS
14
Hide members
10.1KRAS, EGFR, CTNNB1, TP53
15
Hide members
10.1TP53, KRAS, CTNNB1, EGFR
1610.1MYCN, DCX, NKX2-1, SYP
17
Hide members
10.1CTNNB1, KRAS, TP53, WNT1
1810.1TP53, WNT1, VIM, CTNNB1
1910.0VIM, DICER1, EGFR, TP53, KRAS
2010.0WNT1, TP53, KRAS, CTNNB1, EGFR
2110.0KRAS, TP53, ATF1, CTNNB1, EGFR
2210.0TP53, WNT1, KRAS, ATF1, CTNNB1
239.9BIRC7, CTNNB1, EGFR, WNT1, KRAS, TP53

Compounds for genes affiliated with Blastoma

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Blastoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.7MYCN, VIM
2mucicarmine4410.7VIM, NKX2-1, SYP
3cycloheximide4410.6MYCN
4b 7234410.6VIM, NKX2-1, SYP
5temozolomide44 1111.6TP53, EGFR, VIM
6panitumumab44 49 1112.6KRAS, EGFR
7crcs4410.6CTNNB1, KRAS, TP53
8cetuximab44 49 1112.6KRAS, EGFR, CTNNB1
9roscovitine4410.6VIM, CTNNB1, TP53
10leucovorin44 49 1112.5KRAS, CGB, EGFR
11gefitinib44 49 1112.5VIM, CTNNB1, EGFR, KRAS
12adriamycin4410.5TP53, MYCN, CTNNB1, VIM
13paclitaxel44 49 1112.5CTNNB1, EGFR, KRAS, TP53
14s 1004410.5SYP, VIM
15etoposide44 49 59 1113.5VIM, CGB, MYCN, BIRC7
16oxaliplatin44 49 1112.5TP53, KRAS, EGFR
17hematoxylin4410.5SYP, NKX2-1, VIM
18mg 13244 5911.5CTNNB1, EGFR, MYCN, TP53
194-hydroxytamoxifen4410.5VIM, CTNNB1, EGFR
20bromodeoxyuridine4410.5MYCN, DCX, CTNNB1, VIM
21lithium44 49 11 2413.5WNT1, SYP, CTNNB1
22retinoid4410.5VIM, CTNNB1, EGFR, MYCN, TP53
23gnrh4410.5VIM, CTNNB1, CGB, NKX2-1
24agar4410.4WNT1, MYCN, EGFR, CTNNB1, VIM
255fluorouracil4410.4TP53, KRAS, BIRC7, EGFR, CTNNB1
26sb 20358044 5911.4VIM, CTNNB1, EGFR, ATF1, TP53
27irinotecan44 49 1112.4EGFR, KRAS, TP53
28dbc-amp4410.4MYCN, SYP, VIM
29bleomycin44 1111.4CTNNB1, CGB, TP53
30genistein44 28 59 2 11 2415.4VIM, CTNNB1, EGFR, SYP, MYCN
31forskolin44 49 1112.4POU1F1, SYP, NKX2-1, ATF1, VIM
32doxorubicin44 49 1112.4VIM, CTNNB1, EGFR, MYCN, BIRC7, TP53
33h2o24410.3VIM, CTNNB1, SYP, KRAS, SERPINA1, TP53
34cyclic amp44 2411.3VIM, CGB, ATF1, NKX2-1, SYP, POU1F1
35phosphoinositide4410.3VIM, CTNNB1, EGFR, ATF1, POU1F1, KRAS
36leucine4410.3VIM, ATF1, SYP, POU1F1, MYCN
37tamoxifen44 49 28 1113.2TP53, EGFR, CTNNB1, VIM
38adpribose4410.2TP53, EGFR, CTNNB1
39cisplatin44 49 59 1113.2CTNNB1, EGFR, CGB, SYP, MYCN, BIRC7
40vitamin d4410.2VIM, CTNNB1, POU1F1, KRAS
41paraffin4410.2VIM, CTNNB1, EGFR, NKX2-1, SYP, MYCN
42geldanamycin44 49 59 1113.1TP53, EGFR, CTNNB1
43vegf4410.1VIM, CTNNB1, EGFR, CGB, DCX, SYP
44tyrosine4410.1CTNNB1, EGFR, NKX2-1, SYP, POU1F1, MYCN
45testosterone44 59 11 2413.0SYP, CGB, EGFR, CTNNB1, VIM
46retinoic acid44 2411.0VIM, CTNNB1, EGFR, NKX2-1, SYP, POU1F1
47oligonucleotide4410.0VIM, CTNNB1, ATF1, NKX2-1, POU1F1, MYCN
48progesterone44 59 28 11 2413.9TP53, VIM, CTNNB1, EGFR, CGB, ATF1
49nocodazole44 1110.9VIM, CTNNB1, TP53
50serine449.8NKX2-1, ATF1, EGFR, CTNNB1, VIM, DCX

GO Terms for genes affiliated with Blastoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RISC complexGO:01644210.0TARBP2, DICER1
2nucleoplasmGO:0056549.9TP53, TTF1, NKX2-1, ATF1, XPO5, CTNNB1

Biological processes related to Blastoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.6WNT1, CTNNB1
2production of siRNA involved in RNA interferenceGO:03042210.5TARBP2, DICER1
3targeting of mRNA for destruction involved in RNA interferenceGO:03042310.5TARBP2, DICER1
4pre-miRNA processingGO:03105410.5DICER1, TARBP2
5T cell differentiation in thymusGO:03307710.5CTNNB1, WNT1, TP53
6embryonic axis specificationGO:00057810.4WNT1, CTNNB1
7negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.4TP53, WNT1, NKX2-1
8cerebral cortex cell migrationGO:02179510.4NKX2-1, EGFR
9positive regulation of transcription, DNA-dependentGO:04589310.2CTNNB1, NKX2-1, POU1F1, WNT1, TP53
10neuron migrationGO:00176410.2DCX, NKX2-1, CTNNB1
11determination of adult lifespanGO:00834010.2POU1F1, TP53
12positive regulation of protein phosphorylationGO:00193410.2KRAS, WNT1, EGFR
13positive regulation of transcription from RNA polymerase II promoterGO:04594410.2TP53, CTNNB1, DICER1, EGFR, NKX2-1, POU1F1
14negative regulation of transcription from RNA polymerase II promoterGO:00012210.1CTNNB1, DICER1, NKX2-1, POU1F1, TP53
15epithelial tube branching involved in lung morphogenesisGO:06044110.0NKX2-1, CTNNB1

Molecular functions related to Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:04421210.2CTNNB1, NKX2-1, WNT1, TP53
2chromatin bindingGO:00368210.1TP53, TTF1, POU1F1, EGFR, CTNNB1
3sequence-specific DNA binding transcription factor activityGO:00370010.0ATF1, NKX2-1, POU1F1, MYCN, TP53, CTNNB1
4identical protein bindingGO:0428029.9VIM, EGFR, SYP, SERPINA1, TP53
5enzyme bindingGO:0198999.8TP53, BIRC7, EGFR, CTNNB1
6protein bindingGO:0055159.3VIM, CTNNB1, DICER1, XPO5, EGFR, ATF1

Products for genes affiliated with Blastoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blastoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet