MCID: BLS003
MIFTS: 37

Blastoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Blastoma

MalaCards integrated aliases for Blastoma:

Name: Blastoma 12 12 14 69
Embryoma 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0070003 DOID:4766
NCIt 47 C8997
SNOMED-CT 64 86049000
UMLS 69 C0936282

Summaries for Blastoma

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from precursor cells called blast cells.

MalaCards based summary : Blastoma, also known as embryoma, is related to pneumothorax and pleural empyema. An important gene associated with Blastoma is DICER1 (Dicer 1, Ribonuclease III). The drugs Temozolomide and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include lung, pituitary and thyroid, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Related Diseases for Blastoma

Diseases related to Blastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 pneumothorax 30.9 DICER1 SYP
2 pleural empyema 29.6 NKX2-1 SYP TP53
3 pleuropulmonary blastoma 12.4
4 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 12.1
5 pulmonary blastoma 12.1
6 classic pulmonary blastoma 11.9
7 pleuropulmonary blastoma type 1 11.8
8 epithelial predominant pulmonary blastoma 11.7
9 pleuropulmonary blastoma type 2 11.7
10 pleuropulmonary blastoma type 3 11.7
11 dicer1-related disorders 11.0
12 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.6 DICER1 TP53
13 congenital granular cell tumor 10.6 SYP TP53
14 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 SYP TP53
15 hair disease 10.6 SYP TP53
16 childhood choroid plexus cancer 10.6 SYP TP53
17 brachial plexus neuritis 10.5 SYP TP53
18 retinal detachment 10.5 SYP TP53
19 pineoblastoma 10.5 SYP TP53
20 olfactory neural tumor 10.5 SYP TP53
21 pancreatic agenesis 10.5 SYP TP53
22 immune system organ benign neoplasm 10.5 SYP TP53
23 gliofibroma 10.5 SYP TP53
24 group b strep disease in newborns 10.5 SYP TP53
25 glomangioma 10.5 SYP TP53
26 breast pericanalicular fibroadenoma 10.5 NKX2-1 TP53
27 migraine with aura 10.5 SYP TP53
28 hypersensitivity reaction type iii disease 10.5 SYP TP53
29 biliary dyskinesia 10.5 SYP TP53
30 internal auditory canal lipoma 10.5 SYP TP53
31 extragonadal nonseminomatous germ cell tumor 10.5 NKX2-1 TP53
32 middle ear squamous cell carcinoma 10.5 SYP TP53
33 esophagus adenocarcinoma 10.5 NKX2-1 SYP
34 small intestine cancer, childhood 10.5 NKX2-1 SYP
35 large intestine lipoma 10.5 SYP TP53
36 skin papilloma 10.5 NKX2-1 SYP
37 vulvar keratoacanthoma-like carcinoma 10.5 SYP TP53
38 vestibular disease 10.5 SYP TP53
39 ischemia 10.5 DICER1 SYP
40 peritoneal benign neoplasm 10.5 SYP TP53
41 central nervous system hematologic cancer 10.5 NKX2-1 SYP
42 cowper gland carcinoma 10.5 IGF2 TP53
43 spondyloepimetaphyseal dysplasia, isidor type 10.4 NKX2-1 SYP
44 cowden syndrome 3 10.4 NKX2-1 SYP
45 melanotic medulloblastoma 10.4 SYP TP53
46 human t-cell leukemia virus type 1 10.4 NKX2-1 SYP
47 childhood medulloblastoma 10.4 SYP TP53
48 breast epithelioid hemangioma 10.4 IGF2 TP53
49 hip subluxation 10.4 NKX2-1 TP53
50 central nervous system melanocytic neoplasm 10.4 NKX2-1 SYP

Graphical network of the top 20 diseases related to Blastoma:



Diseases related to Blastoma

Symptoms & Phenotypes for Blastoma

MGI Mouse Phenotypes related to Blastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 DICER1 IGF2 LARGE1 NKX2-1 SALL4 SYP
2 cardiovascular system MP:0005385 9.91 DICER1 IGF2 LARGE1 NKX2-1 SALL4 TP53
3 craniofacial MP:0005382 9.8 IGF2 LARGE1 SALL4 TP53 DICER1
4 nervous system MP:0003631 9.8 DICER1 IGF2 LARGE1 NKX2-1 SALL4 SYP
5 digestive/alimentary MP:0005381 9.77 IGF2 LARGE1 NKX2-1 SALL4 TP53
6 reproductive system MP:0005389 9.63 DICER1 IGF2 LARGE1 NKX2-1 SALL4 TP53
7 limbs/digits/tail MP:0005371 9.62 SALL4 TP53 DICER1 IGF2
8 skeleton MP:0005390 9.43 DICER1 IGF2 LARGE1 NKX2-1 SALL4 TP53
9 vision/eye MP:0005391 9.02 DICER1 IGF2 LARGE1 SALL4 TP53

Drugs & Therapeutics for Blastoma

Drugs for Blastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Adenosine Approved, Investigational Phase 2 58-61-7 60961
3
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
4 Alkylating Agents Phase 2
5 Antimitotic Agents Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Ado-trastuzumab emtansine Phase 2
8 Immunoglobulins Phase 2
9 Antibodies, Monoclonal Phase 2
10 Maytansine Phase 2
11 Antibodies Phase 2
12
Doxorubicin Approved, Investigational 23214-92-8 31703
13
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
14
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
15
Ifosfamide Approved 3778-73-2 3690
16
Mechlorethamine Approved 51-75-2 4033
17
Dactinomycin Approved 50-76-0 2019 457193
18
Doxil Approved June 1999 31703
19 Isophosphamide mustard
20 Topoisomerase Inhibitors
21 Nucleic Acid Synthesis Inhibitors
22 Anti-Bacterial Agents
23 Anti-Infective Agents
24 Immunosuppressive Agents
25 Antibiotics, Antitubercular
26 Antirheumatic Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606 Vincristine;Dactinomycin;Cyclophosphamide;Ifosfamide;Doxorubicin
6 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
9 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769

Search NIH Clinical Center for Blastoma

Genetic Tests for Blastoma

Anatomical Context for Blastoma

MalaCards organs/tissues related to Blastoma:

39
Lung, Pituitary, Thyroid, Fetal Lung, Kidney, Brain, Ovary

Publications for Blastoma

Articles related to Blastoma:

(show top 50) (show all 408)
id Title Authors Year
1
Type III pleuropulmonary blastoma in a dicer1 germline mutation carrier: The management of residual lung cystic lesions. ( 28097783 )
2017
2
A pair of DICER1-positive monozygotic twins: One with pleuropulmonary blastoma, another with acute transient hepatitis. ( 28688118 )
2017
3
The impact of local control in the treatment of type II/III pleuropulmonary blastoma. Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS). ( 28103635 )
2017
4
Fine needle aspiration in intraocular metastasis from pleuropulmonary blastoma. A case report and a review of the literature. ( 27718333 )
2017
5
Pulmonary Blastoma in Children: Report of a Rare Case and Review of the Literature. ( 28675947 )
2017
6
Unusual morphology of a pulmonary blastoma having an epithelial component with focally significant nuclear pleomorphism. ( 28543815 )
2017
7
Synthesis of silica-PAMAM dendrimer nanoparticles as promising carriers in Neuro blastoma cells. ( 27939389 )
2017
8
DICER1 mutations in twelve Chinese patients with pleuropulmonary blastoma. ( 28624956 )
2017
9
Pulmonary blastoma in a child: Report of a case with cytological findings. ( 28898554 )
2017
10
It's Rare So Be Aware: Pleuropulmonary Blastoma Mimicking Congenital Pulmonary Airway Malformation. ( 28405541 )
2017
11
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree. ( 28222777 )
2017
12
A Case Report of Pleuropulmonary Blastoma Presenting as Tension Pneumothorax. ( 28469342 )
2017
13
A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma. ( 27877056 )
2016
14
Comment on: DICER1-Negative Pleuropulmonary Blastoma in a Patient With Selective IgA Deficiency. ( 27238822 )
2016
15
DICER1-Negative Pleuropulmonary Blastoma in a Patient With Selective IgA Deficiency. ( 26686196 )
2016
16
Metachronous Type I pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child. ( 27442759 )
2016
17
Reply to comment on: DICER1-negative pleuropulmonary blastoma in a patient with selective IgA deficiency. ( 27443584 )
2016
18
Rhabdoid Tumor Predisposition Syndrome and Pleuropulmonary Blastoma Syndrome. ( 27617153 )
2016
19
Giant pleuropulmonary blastoma. ( 27341849 )
2016
20
What do we know about pulmonary blastoma?: review of literature and clinical case report. ( 28008207 )
2016
21
Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV. ( 27562209 )
2016
22
Biphasic Pulmonary Blastoma Associated with Cerebral Metastasis. ( 26768884 )
2016
23
Pathomechanisms of Congenital Cystic Lung Diseases: Focus on Congenital Cystic Adenomatoid Malformation and Pleuropulmonary Blastoma. ( 26907828 )
2016
24
Reply to the Letter to the Editor 'Type I Pleuropulmonary Blastoma versus Congenital Pulmonary Airway Malformation Type IV'. ( 27577236 )
2016
25
Somatic DICER1 mutations in adult-onset pulmonary blastoma. ( 27126690 )
2016
26
Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature. ( 25755806 )
2015
27
Infant pleuropulmonary blastoma: report of a rare case and review of literature. ( 26722577 )
2015
28
Can congenital pulmonary airway malformation be distinguished from Type I pleuropulmonary blastoma based on clinical and radiological features? ( 26561249 )
2015
29
Unresectable Middle Mediastinal Biphasic Pulmonary Blastoma. ( 26504071 )
2015
30
Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. ( 26698637 )
2015
31
Radiographic Screening of Infants and Young Children With Genetic Predisposition for Rare Malignancies: DICER1 Mutations and Pleuropulmonary Blastoma. ( 25794098 )
2015
32
A Case of Biphasic Pulmonary Blastoma Treated with Carboplatin and Paclitaxel plus Bevacizumab. ( 26075125 )
2015
33
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma. ( 25978641 )
2015
34
Neoadjuvant Chemoradiotherapy Treatment for a Classic Biphasic Pulmonary Blastoma with High PD-L1 Expression. ( 26254381 )
2015
35
Pulmonary blastoma: a case report and brief review of the literature of tumor-induced hypoglycemia. ( 27532029 )
2015
36
Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. ( 25500911 )
2015
37
DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know. ( 26454454 )
2015
38
Somatic DICER1 gene mutation in sporadic intraocular medulloepithelioma without pleuropulmonary blastoma syndrome. ( 25791583 )
2015
39
A Rare Case of Childhood Stiff Person Syndrome Associated With Pleuropulmonary Blastoma. ( 26344328 )
2015
40
Pleuropulmonary blastoma in adolescence: A rare tumor beyond first decade of life. ( 25983419 )
2015
41
Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. ( 26056800 )
2015
42
Pleuropulmonary blastoma: a case report. ( 25560611 )
2015
43
Pleuropulmonary Blastoma in a Neonate Diagnosed Prenatally as Congenital Pulmonary Airway Malformation. ( 26227654 )
2015
44
Adult pulmonary blastoma: Report of an unusual malignant lung tumor. ( 25493248 )
2014
45
Pleuropulmonary blastoma type III extended into the left atrium in a 16-month old boy. ( 24599167 )
2014
46
Nasal chondromesenchymal hamartoma in an adolescent with pleuropulmonary blastoma. ( 25129191 )
2014
47
Pleuropulmonary blastoma: a case report and review of the literature. ( 25177506 )
2014
48
Clinicopathological and Extensive Immunohistochemical Study of a Type II Pleuropulmonary Blastoma. ( 24079261 )
2014
49
Surgery and radiation therapy for brain metastases from classic biphasic pulmonary blastoma. ( 24895392 )
2014
50
Biphasic pulmonary blastoma: An unusual presentation with chest wall, rib, and pleural involvement. ( 24669096 )
2014

Variations for Blastoma

Expression for Blastoma

Search GEO for disease gene expression data for Blastoma.

Pathways for Blastoma

GO Terms for Blastoma

Biological processes related to Blastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 8.92 DICER1 NKX2-1 SALL4 TP53

Molecular functions related to Blastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.96 SYP TP53
2 transcription regulatory region DNA binding GO:0044212 8.8 NKX2-1 SALL4 TP53

Sources for Blastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....