MCID: BLS002
MIFTS: 44

Blastomycosis

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 72 49 3 41 14 69
North American Blastomycosis 12 49
Gilchrist's Disease 12 49
Infection by Blastomyces Dermatitidis 12
Blastomyces Dermatitidis Infection 12
Blastomycotic Infection 12
Gilchrist Disease 69
Chicago Disease 12

Classifications:



Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don’t get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as north american blastomycosis, is related to paracoccidioidomycosis and lobomycosis, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is GC (GC, Vitamin D Binding Protein). The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology : 12 A primary systemic mycosis that results_in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted_by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 49 Blastomycosis is a rare infection that may develop when people inhale a fungus called Blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. The fungus enters the body through the lungs, infecting them. The fungus then spreads to other areas of the body. The infection may affect the skin, bones and joints, and other areas. The disease usually affects people with weakened immune systems, such as those with HIV or who have had an organ transplant. Last updated: 12/9/2011

Wikipedia : 72 Blastomycosis (also known as \"North American blastomycosis\", \"Blastomycetic dermatitis\", and... more...

Related Diseases for Blastomycosis

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

Symptoms:

12
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 5280965 14956
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
deoxycholic acid Approved Phase 4 83-44-3 222528
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Antiparasitic Agents Phase 4,Phase 3
9 Antiprotozoal Agents Phase 4,Phase 3
10 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
11 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Liposomal amphotericin B Phase 4,Phase 3
16 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Amphotericin B, deoxycholate drug combination Phase 4
18
Itraconazole Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 84625-61-6 55283
19 Antibiotics, Antitubercular Phase 3
20 Hydroxyitraconazole Phase 3,Phase 1,Phase 2,Early Phase 1
21 Pharmaceutical Solutions Phase 3,Early Phase 1
22
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
24
Petrolatum Approved, Investigational Early Phase 1 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Recruiting NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

38
Lung, Skin, Bone, Testes, Thyroid, Lymph Node, Prostate

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 581)
# Title Authors Year
1
Central nervous system blastomycosis diagnosed using the MVistaAr Blastomyces quantitative antigen enzyme immunoassay test on cerebrospinal fluid: A case report and review of the literature. ( 29195765 )
2018
2
Primary Cutaneous Blastomycosis After Inoculation From A Woodworking Blade. ( 29169917 )
2018
3
Fine needle aspiration cytology of acute blastomycosis thyroiditis. ( 28792123 )
2017
4
Blastomycosis-like pyoderma: Novel use of potassium iodide. ( 28980537 )
2017
5
A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012). ( 28561957 )
2017
6
Successful treatment of blastomycosis in a 7-year-old, female golden retriever dog on Manitoulin Island, Ontario. ( 28588338 )
2017
7
Blastomycosis ( 28723016 )
2017
8
Not just another Wisconsin case of blastomycosis. ( 29293961 )
2017
9
Invasive Trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. ( 28627008 )
2017
10
Disseminated blastomycosis in a 57-year-old man working in construction. ( 29229716 )
2017
11
Disseminated Blastomycosis Mimicking Malignancy. ( 28813733 )
2017
12
Cutaneous blastomycosis and dermatophytic pseudomycetoma in a Persian cat from Bangkok, Thailand. ( 28116230 )
2017
13
Clinical Manifestations and Treatment of Blastomycosis. ( 28797487 )
2017
14
Disseminated Blastomycosis. ( 28177861 )
2017
15
Blastomycosis during pregnancy: a case report and review of the literature. ( 28291633 )
2017
16
An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. ( 28300442 )
2017
17
Multimodality imaging in cranial blastomycosis, a great mimicker: Case-based illustration with review of clinical and imaging findings. ( 27081235 )
2016
18
Management and Outcomes of Acute Respiratory Distress Syndrome Caused by Blastomycosis: A Retrospective Case Series. ( 27149459 )
2016
19
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years. ( 26776602 )
2016
20
Diagnostic Delay and Antibiotic Overuse in Acute Pulmonary Blastomycosis. ( 27419155 )
2016
21
Blastomycosis-Like Pyoderma- A Rare Case Report. ( 27891438 )
2016
22
Blastomycosis infection in an adolescent patient with Hodgkin lymphoma. ( 27663466 )
2016
23
Blastomycosis and Histoplasmosis in a Patient with Glioblastoma Receiving Temozolomide. ( 28806010 )
2016
24
Blastomycosis. ( 26739607 )
2016
25
SYSTEMIC BLASTOMYCOSIS IN A CAPTIVE RED RUFFED LEMUR (VARECIA RUBRA). ( 27691971 )
2016
26
Central Nervous System Blastomycosis in Children - A Case Report and Review of the Literature. ( 28033237 )
2016
27
Reversal of Fortune: Central Nervous System Blastomycosis. ( 26477951 )
2016
28
Blastomycosis of the nose: A case report. ( 27551850 )
2016
29
Case 233: Blastomycosis. ( 27533292 )
2016
30
Blastomycosis in the Eyelid of a Native Chicagoan. ( 26711133 )
2015
31
677: CLINICAL OUTCOMES OF BLASTOMYCOSIS IN THE ICU-A RETROSPECTIVE STUDY. ( 26570338 )
2015
32
Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections. ( 26143434 )
2015
33
Blastomycosis in Children: An Analysis of Clinical, Epidemiologic, and Genetic Features. ( 26703241 )
2015
34
GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis. ( 26395816 )
2015
35
Atypical Cutaneous Blastomycosis in a Child With Juvenile Idiopathic Arthritis on Infliximab. ( 26482671 )
2015
36
Coccidioidomycosis and Blastomycosis: Endemic Mycotic Co-Infections in the HIV Patient. ( 25584108 )
2015
37
Extracorporeal membrane oxygenation for blastomycosis-related severe ARDS: a new indication as a rescue therapy? ( 25877831 )
2015
38
Cerebral Blastomycosis: Radiologic-Pathologic Correlation of Solitary CNS Blastomycosis Mass-Like Infection. ( 26167388 )
2015
39
Blastomyces Antigen Detection for Diagnosis and Management of Blastomycosis. ( 26338856 )
2015
40
Blastomycosis in Indiana: Clinical and Epidemiologic Patterns of Disease Gleaned from a Multicenter Retrospective Study. ( 26020566 )
2015
41
Perianal North American blastomycosis. ( 26367760 )
2015
42
Evaluation of an enzyme immunoassay for antibodies to a recombinant Blastomyces adhesin-1 repeat antigen as an aid in the diagnosis of blastomycosis in dogs. ( 26517616 )
2015
43
Blastomycosis and Pregnancy: An Unusual Postpartum Disease Course. ( 26120305 )
2015
44
New Developments in Blastomycosis. ( 26398538 )
2015
45
Anterior cervical corpectomy and fusion for blastomycosis causing destruction of C6 vertebra: a case report. ( 26607290 )
2015
46
Disseminated blastomycosis with cutaneous involvement in a Canadian railroad worker. ( 25467582 )
2015
47
Dermatoscopic and clinicopathologic findings of cutaneous blastomycosis. ( 26475557 )
2015
48
Spatial epidemiology of blastomycosis hospitalizations: detecting clusters and identifying environmental risk factors. ( 25908653 )
2015
49
Blastomycosis in northwestern Ontario, 2004 to 2014. ( 26600814 )
2015
50
Blastomycosis infection of the knee treated with staged total knee arthroplasty. ( 26081592 )
2015

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

GO Terms for Blastomycosis

Cellular components related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 ALB GC

Molecular functions related to Blastomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 ALB HSPE1

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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