MCID: BLS002
MIFTS: 54

Blastomycosis malady

Rare diseases, Infectious diseases, Skin diseases categories
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Summaries for Blastomycosis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 4CDC, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Blastomycosis is a rare infection that may develop when people inhale a fungus called blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. the fungus enters the body through the lungs, infecting them. the fungus then spreads to other areas of the body. the infection may affect the skin, bones and joints, and other areas. the disease usually affects people with weakened immune systems, such as those with hiv or who have had an organ transplant. last updated: 12/9/2011

MalaCards: Blastomycosis, also known as north american blastomycosis, is related to north american indian childhood cirrhosis and histoplasmosis, and has symptoms including pleural thickening, lung lesions and skin lesions. An important gene associated with Blastomycosis is ALB (albumin). The drugs ketoconazole and itraconazole and the compounds potassium and calcium have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone.

Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

CDC:4 Blastomycosis is a disease caused by the fungus Blastomyces dermatitidis. The fungus lives in moist soil and in association with decomposing organic matter such as wood and leaves. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of blastomycosis are similar to flu symptoms, and the infection can sometimes become serious if it is not treated.

Wikipedia:65 Blastomycosis (also known as \"North American blastomycosis\", \"Blastomycetic dermatitis\", and... more...

Aliases & Classifications for Blastomycosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

blastomycosis 8 43 10 62
north american blastomycosis 8 43
other dermatophytosis 8 62
gilchrist's disease 8 43
infection by blastomyces dermatitidis 8
blastomycosis & chicago disease 8
blastomyces dermatitidis infection 8
blastomycotic infection nos 8
blastomycosis, unspecified 8
blastomycotic infection 8
gilchrists disease 8
blastomycosis nos 8
gilchrist disease 62
chicago disease 8
north american 8


External Ids:

Disease Ontology8 DOID:12663
MeSH35 D001759
ICD9CM27 116.0, 116
ICD1025 B40, B40.9

Related Diseases for Blastomycosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to blastomycosis

Symptoms for Blastomycosis

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8Disease Ontology
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Symptoms:

8
  • pleural thickening
  • lung lesions
  • skin lesions

Drugs & Therapeutics for Blastomycosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Blastomycosis

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Blastomycosis

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Anatomical Context for Blastomycosis

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33MalaCards
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MalaCards organs/tissues related to Blastomycosis:

33
Lung, Skin, Bone, Testes, Thyroid, Brain, Lymph node, Myeloid, Breast, Eye, Prostate, Spinal cord

Animal Models for Blastomycosis or affiliated genes

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Publications for Blastomycosis

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52PubMed
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Articles related to Blastomycosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Infliximab-associated Blastomycosis dermatitidis in treatment of ulcerative colitis. (23046403)
2013
2
Unusual osseous presentation of blastomycosis in an immigrant child: a challenge for European pediatricians. (23228191)
2012
3
Blastomycosis presenting as a nonhealing wound. (22713783)
2012
4
Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis. (21367980)
2011
5
Blastomycosis in man after kinkajou bite. (21291603)
2011
6
Blastomycosis: a differential diagnosis of periampullary tumors. (20861704)
2010
7
Clinical and laboratory update on blastomycosis. (20375357)
2010
8
Blastomycosis. (20463245)
2010
9
Central nervous system blastomycosis in a dog. (19949557)
2009
10
Pulmonary blastomycosis: a case from Africa. (18979049)
2008
11
Corticosteroids for blastomycosis-induced ARDS: a report of two patients and review of the literature. (18574291)
2008
12
Systemic blastomycosis in a horse. (17121096)
2006
13
Blastomycosis presenting as recurrent tender cutaneous nodules. (16821476)
2006
14
Immunological basis for susceptibility and resistance to pulmonary blastomycosis in mouse strains. (16183299)
2005
15
A case of blastomycosis in pregnancy. (16198812)
2005
16
Blastomyces dermatitidis lysate antigens: antibody detection in serial serum specimens from dogs with blastomycosis. (14682453)
2003
17
Cutaneous inoculation blastomycosis. (11981746)
2002
18
Blastomycosis is a serious disease, but let's not raise fears without conclusive data. (11816783)
2001
19
First case of combined blastomycosis and tuberculosis in a patient from Saudi Arabia. (11434534)
2001
20
Verrucous plaques on the face. North American blastomycosis. (10768656)
2000
21
Disseminated mucocutaneous blastomycosis in a immunocompetent Indian patient. (11204539)
2000
22
From the Centers for Disease Control and Prevention. Blastomycosis acquired occupationally during prairie dog relocation--Colorado, 1998. (10404898)
1999
23
Thoracic and abdominal blastomycosis in a horse. (10319179)
1999
24
Blastomycosis in dogs: 115 cases (1980-1995). (9731260)
1998
25
Intracranial blastomycosis presenting as a suprasellar mass: MR findings. (9294589)
1997
26
Update and review of blastomycosis. (9313349)
1997
27
Endemic blastomycosis in Mississippi: epidemiological and clinical studies. (9313293)
1997
28
Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. (8960189)
1996
29
Cutaneous lesions provide a clue to mysterious pulmonary process. Pulmonary and cutaneous North American blastomycosis infection. (8678579)
1996
30
Sensitivity and specificity of an isoelectric focusing fraction of Blastomyces dermatitidis yeast lysate antigen for the detection of canine blastomycosis. (8531928)
1995
31
Blastomycosis of the forearm synovium in a child. (7671483)
1995
32
Addison's disease caused by adrenal blastomycosis: a case report with fine needle aspiration (FNA) cytology. (8520008)
1995
33
Primary cutaneous blastomycosis: report of a case acquired by direct inoculation of a bullous pemphigoid lesion. (8040417)
1994
34
Delayed treatment of pulmonary blastomycosis causing vertebral osteomyelitis, paraspinal abscess, and spinal cord compression. (8191232)
1994
35
Image interpretation session: 1993. Pulmonary North American blastomycosis. (8128062)
1994
36
Reactivation and dissemination of blastomycosis complicating Hodgkin's disease: a case report and review of the literature. (8342540)
1993
37
Blastomycosis in otolaryngology: review of a large series. (8421419)
1993
38
Epidemiology of blastomycosis in a region of high endemicity in north central Wisconsin. (8507766)
1993
39
Blastomycosis: a reminder of Kentucky's other fungus. (1479260)
1992
40
Otitis media due to blastomycosis: report of two cases. (1571452)
1992
41
SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis. (2069391)
1991
42
Hyperendemic urban blastomycosis. (2014867)
1991
43
Treatment of murine pulmonary blastomycosis with SCH 39304, a new triazole antifungal agent. (2360825)
1990
44
Orthopaedic manifestations of blastomycosis. (2365718)
1990
45
Blastomycosis: fungal infections of the lung update: 1989. (2247705)
1990
46
Miliary blastomycosis and HIV infection. (2253140)
1990
47
Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis. (2729949)
1989
48
Water and blastomycosis: don't blame beaver. (3688633)
1987
49
Splenic abscess due to blastomycosis: scintigraphic, sonographic, and CT evaluation. (6600327)
1983
50
Epidermodysplasia of Lewandowski and Lutz? Abortive Form of Blastomycosis or Chromoblastomycosis? (19993518)
1947

Variations for Blastomycosis

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Expression for genes affiliated with Blastomycosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for genes affiliated with Blastomycosis

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Compounds for genes affiliated with Blastomycosis

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Blastomycosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1potassium45 24 1110.8ALB, KCNB1
2calcium45 51 24 1111.5SLA2, ALB, KCNB1

GO Terms for genes affiliated with Blastomycosis

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16Gene Ontology
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Molecular functions related to Blastomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474858.7SLA2, KCNB1
2protein bindingGO:0055158.0SLA2, ERC2, ALB, KCNB1

Products for genes affiliated with Blastomycosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blastomycosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet