MCID: BLS002
MIFTS: 40

Blastomycosis

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Blastomycosis

MalaCards integrated aliases for Blastomycosis:

Name: Blastomycosis 12 50 3 42 14 69
North American Blastomycosis 12 50
Gilchrist's Disease 12 50
Infection by Blastomyces Dermatitidis 12
Blastomyces Dermatitidis Infection 12
Blastomycotic Infection 12
Gilchrist Disease 69
Chicago Disease 12

Classifications:



Summaries for Blastomycosis

CDC : 3 Blastomycosis is an infection caused by a fungus called Blastomyces. The fungus lives in the environment, particularly in moist soil and in decomposing matter such as wood and leaves. Blastomyces mainly lives in areas of the United States and Canada surrounding the Ohio and Mississippi River valleys and the Great Lakes. People can get blastomycosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don’t get sick, some of those who do may have flu-like symptoms, and the infection can sometimes become serious if it is not treated.

MalaCards based summary : Blastomycosis, also known as north american blastomycosis, is related to lobomycosis and paracoccidioidomycosis. An important gene associated with Blastomycosis is GC (GC, Vitamin D Binding Protein), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone, and related phenotype is endocrine/exocrine gland.

Disease Ontology : 12 A primary systemic mycosis that results_in a systemic fungal infection, has material basis in Blastomyces dermatitidis, transmitted_by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

NIH Rare Diseases : 50 blastomycosis is a rare infection that may develop when people inhale a fungus called blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. the fungus enters the body through the lungs, infecting them. the fungus then spreads to other areas of the body. the infection may affect the skin, bones and joints, and other areas. the disease usually affects people with weakened immune systems, such as those with hiv or who have had an organ transplant. last updated: 12/9/2011

Wikipedia : 72 Blastomycosis (also known as \"North American blastomycosis\", \"Blastomycetic dermatitis\", and... more...

Related Diseases for Blastomycosis

Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to Blastomycosis

Symptoms & Phenotypes for Blastomycosis

MGI Mouse Phenotypes related to Blastomycosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 ALB GATA2 GC KCNB1

Drugs & Therapeutics for Blastomycosis

Drugs for Blastomycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
deoxycholic acid Approved Phase 4 83-44-3 222528
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5 Anti-Bacterial Agents Phase 4,Phase 3
6 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Antiparasitic Agents Phase 4,Phase 3
9 Antiprotozoal Agents Phase 4,Phase 3
10 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
11 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Liposomal amphotericin B Phase 4,Phase 3
16 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Amphotericin B, deoxycholate drug combination Phase 4
18
Itraconazole Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 84625-61-6 55283
19 Antibiotics, Antitubercular Phase 3
20 Hydroxyitraconazole Phase 3,Phase 1,Phase 2,Early Phase 1
21 Pharmaceutical Solutions Phase 3,Early Phase 1
22
Fluconazole Approved Phase 2 86386-73-4 3365
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
24
Petrolatum Approved Early Phase 1 8009-03-8

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Amphotericin-B and Voriconazole for Pulmonary Blastomycosis Recruiting NCT02283905 Phase 4 amphotericin-B;voriconazole
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
4 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
5 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
6 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection Completed NCT00001702
7 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole

Search NIH Clinical Center for Blastomycosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: blastomycosis

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

MalaCards organs/tissues related to Blastomycosis:

39
Lung, Skin, Bone, Testes, Thyroid, Prostate, Lymph Node

Publications for Blastomycosis

Articles related to Blastomycosis:

(show top 50) (show all 576)
id Title Authors Year
1
Disseminated Blastomycosis. ( 28177861 )
2017
2
Clinical Manifestations and Treatment of Blastomycosis. ( 28797487 )
2017
3
Fine needle aspiration cytology of acute blastomycosis thyroiditis. ( 28792123 )
2017
4
Disseminated Blastomycosis Mimicking Malignancy. ( 28813733 )
2017
5
Blastomycosis ( 28723016 )
2017
6
Blastomycosis during pregnancy: a case report and review of the literature. ( 28291633 )
2017
7
Cutaneous blastomycosis and dermatophytic pseudomycetoma in a Persian cat from Bangkok, Thailand. ( 28116230 )
2017
8
Invasive Trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. ( 28627008 )
2017
9
An Atypical Case of Mucocutaneous Blastomycosis in the Greater Toronto Area. ( 28300442 )
2017
10
A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012). ( 28561957 )
2017
11
Successful treatment of blastomycosis in a 7-year-old, female golden retriever dog on Manitoulin Island, Ontario. ( 28588338 )
2017
12
Blastomycosis and Histoplasmosis in a Patient with Glioblastoma Receiving Temozolomide. ( 28806010 )
2016
13
Blastomycosis infection in an adolescent patient with Hodgkin lymphoma. ( 27663466 )
2016
14
Reversal of Fortune: Central Nervous System Blastomycosis. ( 26477951 )
2016
15
SYSTEMIC BLASTOMYCOSIS IN A CAPTIVE RED RUFFED LEMUR (VARECIA RUBRA). ( 27691971 )
2016
16
Management and Outcomes of Acute Respiratory Distress Syndrome Caused by Blastomycosis: A Retrospective Case Series. ( 27149459 )
2016
17
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years. ( 26776602 )
2016
18
Diagnostic Delay and Antibiotic Overuse in Acute Pulmonary Blastomycosis. ( 27419155 )
2016
19
Multimodality imaging in cranial blastomycosis, a great mimicker: Case-based illustration with review of clinical and imaging findings. ( 27081235 )
2016
20
Blastomycosis of the nose: A case report. ( 27551850 )
2016
21
Central Nervous System Blastomycosis in Children - A Case Report and Review of the Literature. ( 28033237 )
2016
22
Blastomycosis. ( 26739607 )
2016
23
Case 233: Blastomycosis. ( 27533292 )
2016
24
Blastomycosis-Like Pyoderma- A Rare Case Report. ( 27891438 )
2016
25
Perianal North American blastomycosis. ( 26367760 )
2015
26
Dermatoscopic and clinicopathologic findings of cutaneous blastomycosis. ( 26475557 )
2015
27
Cerebral Blastomycosis: Radiologic-Pathologic Correlation of Solitary CNS Blastomycosis Mass-Like Infection. ( 26167388 )
2015
28
Disseminated blastomycosis with cutaneous involvement in a Canadian railroad worker. ( 25467582 )
2015
29
Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections. ( 26143434 )
2015
30
Blastomycosis infection of the knee treated with staged total knee arthroplasty. ( 26081592 )
2015
31
Hypercoagulability in dogs with blastomycosis. ( 25818206 )
2015
32
Pathology in Practice. Blastomycosis in an indoor-only cat. ( 26225606 )
2015
33
Anterior cervical corpectomy and fusion for blastomycosis causing destruction of C6 vertebra: a case report. ( 26607290 )
2015
34
New Developments in Blastomycosis. ( 26398538 )
2015
35
677: CLINICAL OUTCOMES OF BLASTOMYCOSIS IN THE ICU-A RETROSPECTIVE STUDY. ( 26570338 )
2015
36
Atypical Cutaneous Blastomycosis in a Child With Juvenile Idiopathic Arthritis on Infliximab. ( 26482671 )
2015
37
Evaluation of an enzyme immunoassay for antibodies to a recombinant Blastomyces adhesin-1 repeat antigen as an aid in the diagnosis of blastomycosis in dogs. ( 26517616 )
2015
38
Blastomycosis in northwestern Ontario, 2004 to 2014. ( 26600814 )
2015
39
Blastomyces Antigen Detection for Diagnosis and Management of Blastomycosis. ( 26338856 )
2015
40
Extracorporeal membrane oxygenation for blastomycosis-related severe ARDS: a new indication as a rescue therapy? ( 25877831 )
2015
41
Blastomycosis and Pregnancy: An Unusual Postpartum Disease Course. ( 26120305 )
2015
42
Coccidioidomycosis and Blastomycosis: Endemic Mycotic Co-Infections in the HIV Patient. ( 25584108 )
2015
43
Blastomycosis in the Eyelid of a Native Chicagoan. ( 26711133 )
2015
44
Blastomycosis in Indiana: Clinical and Epidemiologic Patterns of Disease Gleaned from a Multicenter Retrospective Study. ( 26020566 )
2015
45
Cutaneous blastomycosis. An imported case with good response to itraconazole. ( 26422322 )
2015
46
Spatial epidemiology of blastomycosis hospitalizations: detecting clusters and identifying environmental risk factors. ( 25908653 )
2015
47
Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series. ( 25851019 )
2015
48
Blastomycosis in Children: An Analysis of Clinical, Epidemiologic, and Genetic Features. ( 26703241 )
2015
49
GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis. ( 26395816 )
2015
50
Budding Issues: Blastomycosis. ( 26164562 )
2015

Variations for Blastomycosis

Expression for Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for Blastomycosis

Pathways related to Blastomycosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.75 ALB GATA2

GO Terms for Blastomycosis

Cellular components related to Blastomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 ALB GC

Molecular functions related to Blastomycosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 ALB HSPE1

Sources for Blastomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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