MCID: BLS002
MIFTS: 48

Blastomycosis malady

Infectious category

Summaries for Blastomycosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 3CDC, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Blastomycosis is a rare infection that may develop when people inhale a fungus called blastomyces dermatitidis, a fungus that is found in moist soil, particularly where there is rotting vegetation. the fungus enters the body through the lungs, infecting them. the fungus then spreads to other areas of the body. the infection may affect the skin, bones and joints, and other areas. the disease usually affects people with weakened immune systems, such as those with hiv or who have had an organ transplant. last updated: 12/9/2011

MalaCards: Blastomycosis, also known as north american blastomycosis, is related to north american indian childhood cirrhosis and malignant hyperthermia, and has symptoms including skin lesions, lung lesions and pleural thickening. An important gene associated with Blastomycosis is ALB (albumin). The drugs ketoconazole and itraconazole and the compound calcium have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and spinal cord.

Disease Ontology:8 A primary systemic mycosis that results in a systemic fungal infection, has material basis in blastomyces dermatitidis, transmitted by airborne spores and has symptom skin lesions, has symptom lung lesions and has symptom pleural thickening.

CDC:3 Blastomycosis is a disease caused by the fungus Blastomyces dermatitidis. The fungus lives in moist soil and in association with decomposing organic matter such as wood and leaves. Lung infection can occur after a person inhales airborne, microscopic fungal spores from the environment; however, many people who inhale the spores do not get sick. The symptoms of blastomycosis are similar to flu symptoms, and the infection can sometimes become serious if it is not treated.

Wikipedia:64 Blastomycosis (also known as \"North American blastomycosis\", \"Blastomycetic dermatitis\", and... more...

Aliases & Classifications for Blastomycosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

blastomycosis 8 43 10 61
north american blastomycosis 8 43
other dermatophytosis 8 61
gilchrist's disease 8 43
infection by blastomyces dermatitidis 8
blastomycosis & chicago disease 8
blastomyces dermatitidis infection 8
blastomycotic infection nos 8
blastomycosis, unspecified 8
blastomycotic infection 8
gilchrists disease 8
blastomycosis nos 8
gilchrist disease 61
chicago disease 8
north american 8


External Ids:

Disease Ontology8 DOID:12663
MeSH35 D001759
ICD9CM27 116, 116.0
ICD1025 B40, B40.9

Related Diseases for Blastomycosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Blastomycosis:



Diseases related to blastomycosis

Clinical Features for Blastomycosis

Sources:
8Disease Ontology
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Symptoms:

8
  • skin lesions
  • lung lesions
  • pleural thickening

Drugs & Therapeutics for Blastomycosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Blastomycosis

Drug clinical trials:

Search ClinicalTrials for Blastomycosis

Search NIH Clinical Center for Blastomycosis

Search CenterWatch for Blastomycosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Blastomycosis

Anatomical Context for Blastomycosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Blastomycosis:

33
Lymph node, Brain, Spinal cord, Lung, Thyroid, Breast, Skin, Prostate, Myeloid, T cells, B cells

Animal Models for Blastomycosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Blastomycosis

Sources:
51PubMed
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Articles related to Blastomycosis:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Development of a slide agglutination assay for detection of blastomycosis. (24028710)
2013
2
Carpal intra-articular blastomycosis in a Labrador retriever. (23904641)
2013
3
Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis. (21251563)
2011
4
Effects of season and weather on blastomycosis in dogs: Northern Wisconsin, USA. (20491530)
2011
5
Blastomycosis. (19220495)
2009
6
Pustular blastomycosis. (19615547)
2009
7
Pulmonary blastomycosis: a case from Africa. (18979049)
2008
8
Corticosteroids for blastomycosis-induced ARDS: a report of two patients and review of the literature. (18574291)
2008
9
Radiographic findings in dogs with pulmonary blastomycosis: 125 cases (1989-2006). (18275388)
2008
10
Seasonal variations in the clinical presentation of pulmonary and extrapulmonary blastomycosis. (18651302)
2008
11
Invasive Trichophyton rubrum infection resembling blastomycosis in a patient with altered immune status during the course of chronic superficial Trichophyton rubrum infection. (17673400)
2007
12
Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole. (16567998)
2006
13
Chronic disseminated cutaneous blastomycosis in an 11-year old, with a brief review of the literature. (17155995)
2006
14
Pharyngeal--laryngeal blastomycosis in a dog. (14705432)
2003
15
Blastomycosis in nondomestic felids. (14582783)
2003
16
Blastomycosis in Missouri: epidemiology and risk factors for endemic disease. (14596532)
2003
17
Blastomycosis: The great pretender can also be an opportunist. Initial clinical diagnosis and underlying diseases in 123 patients. (12089732)
2002
18
Blastomycosis and pregnancy. (12170451)
2002
19
Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation. (11998870)
2002
20
CT findings of intracranial blastomycosis in a dog. (11871374)
2002
21
Blastomycosis is a serious disease, but let's not raise fears without conclusive data. (11816783)
2001
22
Public health response to 2 clinical cases of blastomycosis in colorado residents. (11340548)
2001
23
Amphotericin B lipid complex for the treatment of recurrent blastomycosis of the brain in a patient previously treated with itraconazole. (11372815)
2001
24
Recurrent blastomycosis of the central nervous system: case report and review. (10880319)
2000
25
Expanding epidemiology of blastomycosis: clinical features and investigation of 2 cases in Colorado. (10722448)
2000
26
Blastomycosis acquired occupationally during prairie dog relocation--Colorado, 1998. (10072267)
1999
27
North American blastomycosis in South Africa simulating tuberculosis. (10210348)
1999
28
Laryngeal manifestations of paracoccidioidomycosis (South American blastomycosis). (10604418)
1999
29
Disseminated North American blastomycosis in an adolescent male: a delay in diagnosis. (9786775)
1998
30
Vertebral blastomycosis with paravertebral abscess: report of eight cases and review of the literature. (9502464)
1998
31
Blastomycosis-like pyoderma in a man with AIDS. (9092755)
1997
32
Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. (8960189)
1996
33
Blastomycosis--Wisconsin, 1986-1995. (8676851)
1996
34
Treatment of blastomycosis with itraconazole in 112 dogs. (8947868)
1996
35
Female genital blastomycosis: case report and review. (8729218)
1996
36
Sensitivity and specificity of an isoelectric focusing fraction of Blastomyces dermatitidis yeast lysate antigen for the detection of canine blastomycosis. (8531928)
1995
37
Epidemiology of blastomycosis in a region of high endemicity in north central Wisconsin. (8507766)
1993
38
IL-4, IgE, and interferon-gamma production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304). (7687197)
1993
39
Subconjunctival miconazole and anterior segment blastomycosis. (8213986)
1993
40
Paracoccidioidomycosis (South American blastomycosis, Lutz's mycosis). (8125682)
1993
41
Blastomycosis: a reminder of Kentucky's other fungus. (1479260)
1992
42
Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study Group. (1332471)
1992
43
Adult respiratory distress syndrome due to blastomycosis during pregnancy. (2245702)
1990
44
Evidence of subclinical blastomycosis in forestry workers in northern Minnesota and northern Wisconsin. (2220880)
1990
45
A new enzyme immunoassay specific for blastomycosis. (2105073)
1990
46
Blastomycosis in Washington Parish, Louisiana, 1976-1985. (2787106)
1989
47
Late dissemination of pulmonary blastomycosis during ketoconazole therapy. (2909344)
1989
48
Clinical usefulness of skin testing in histoplasmosis, coccidioidomycosis, and blastomycosis. This Official Statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1987. (3202445)
1988
49
Blastomycosis presenting as polyarticular septic arthritis. (3199404)
1988
50
Use of a urease-antibody conjugate in an enzyme immunoassay for the detection of blastomycosis. (3668759)
1987

Genetic Variations for Blastomycosis

Expression for genes affiliated with Blastomycosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blastomycosis

Search GEO for disease gene expression data for Blastomycosis.

Pathways for genes affiliated with Blastomycosis

Compounds for genes affiliated with Blastomycosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Blastomycosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2411.1ALB, SLA2, PKD2L1, KCNB1

GO Terms for genes affiliated with Blastomycosis

Sources:
16Gene Ontology
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Molecular functions related to Blastomycosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.1SLA2, KCNB1

Products for genes affiliated with Blastomycosis

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  • Lysates
  • Antibodies

Sources for Blastomycosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet