Bleeding Disorder malady

MalaCards: Bleeding Disorder, also known as bleeding tendency, is related to hepatitis and prothrombin deficiency. An important gene associated with Bleeding Disorder is BDET (Bleeding disorder, east Texas type), and among its related pathways are Gamma-carboxylation of protein precursors and Cell adhesion_Integrin inside-out signaling. The compounds cyclophosphamide and clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include liver and b cells, and related mouse phenotypes are reproductive system and hematopoietic system.

bleeding disorder 7 bleeding tendency 43

Diseases related to bleeding disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 413)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	30.1	SERPINA1, IFNA1, IFNA2, F2
2	prothrombin deficiency	29.2	SERPINC1, F5, F2
3	scott syndrome	28.9	ANO6, F5, F2, F10, TNXA, PLEK
4	quebec platelet disorder	28.9	MMRN1, F5, F10, PLAU
5	hemophilia b	28.4	VWF, F9, F8, F7, F3, F2
6	dysprothrombinemia	28.2	F2, F10
7	hemolytic anemia	28.2	VWF, CFI, IFNA1, IFNA2, F5, F3
8	von willebrand's disease	27.9	VWF, ITGA2B, GP1BA, F9, F8, F7
9	autoimmune thrombocytopenic purpura	27.9	VWF, ITGA2B, ITGB3
10	vitamin k-dependent clotting factors	27.9	VKORC1, F9, F5, F2, F10
11	hemophilia	27.8	VWF, SERPINC1, LMAN1, MCFD2, IFNA1, IFNA2
12	afibrinogenemia	27.8	VWF, CFI, F3, F2
13	acquired von willebrand syndrome	27.6	VWF, F8, F3, F2, F11
14	esophageal varix	27.5	F2, SST
15	dysfibrinogenemia	27.3	SERPINC1, F5, F2, F10, F13A1
16	thrombasthenia	27.2	VWF, ITGA2, ITGA2B, ITGB3, GP1BA, F9
17	bernard-soulier syndrome	26.8	VWF, ITGA2, ITGA2B, ITGB3, GP5, GP1BA
18	bleeding diathesis due to gnaq deficiency	26.7	VWF, SERPINC1, SERPINF2, SERPINE1, P2RY12, GP1BA
19	glanzmann's thrombasthenia	26.3	VWF, ITGA2, ITGA2B, ITGB3, GP1BA, F9
20	gingivitis	26.0	SERPINF2, SERPINE1, ITGA2, ITGB3, ANXA5, F3
21	hepatitis c	25.6	SERPINC1, SERPINF2, SERPINA1, ITGA2, ITGA2B, ITGB3
22	hemorrhagic fever	24.4	SERPINC1, ITGA2B, ITGB3, IFNA1, IFNA2, F8
23	anemia	23.8	VWF, SERPINC1, LMAN1, CFI, ITGA2, ITGA2B
24	disseminated intravascular coagulation	23.8	VWF, SERPINC1, SERPINF2, SERPINE1, GP1BA, IFNA1
25	thrombophilia	23.6	VWF, SERPINC1, SERPINF2, SERPINE1, ITGB3, ANXA5
26	factor v leiden thrombophilia	23.4	VWF, SERPINC1, SERPINF2, SERPINA1, SERPINE1, VKORC1
27	multiple myeloma	22.9	VWF, SERPINC1, ITGA2, ITGB3, ANXA5, IFNA1
28	esophagitis	21.7	SERPINC1, SERPINF2, SERPINE1, ITGA2, ANXA5, IFNA1
29	myeloma	21.4	VWF, SERPINC1, ITGA2, ITGB3, ANXA5, GP1BA
30	atherosclerosis	19.9	VWF, SERPINC1, SERPINF2, SERPINA1, SERPINE1, VKORC1
31	factor v and factor viii, combined deficiency of	13.7	LMAN1, MCFD2
32	combined factor v and viii deficiency	13.7	LMAN1, MCFD2, F5
33	warfarin resistance	13.6	VKORC1, MCFD2, F2
34	warfarin sensitivity	13.6	VKORC1, F9, F10
35	stroke, ischemic	13.6	F5, F2
36	neonatal alloimmune thrombocytopenia	13.6	ITGA2, ITGA2B, ITGB3, MMRN1
37	factor v and factor viii	13.5	LMAN1, MCFD2, F8, F5
38	pseudo-von willebrand disease	13.5	VWF, GP1BA
39	type 1 von willebrand disease	13.5	VWF, P2RY12, F8
40	thrombosis	13.5	F8, F5, F2
41	blood protein disease	13.4	F5, F2
42	macrothrombocytopenia	13.4	ITGA2B, ITGB3, GP5, GP1BA, TUBB1
43	type 3 von willebrand disease	13.4	VWF, F8
44	spinal cord infarction	13.4	SERPINC1, F5, F2
45	vein disease	13.4	SERPINC1, F5, F2
46	sagittal sinus thrombosis	13.3	SERPINC1, F5, F3
47	acute fatty liver of pregnancy	13.3	SERPINC1, F3, F2
48	alpha-1-antichymotrypsin deficiency	13.3	SERPINC1, SERPINF2, SERPINA1
49	placental abruption	13.3	SERPINC1, F5
50	vitamin k deficiency hemorrhagic disease	13.3	VKORC1, F9, F7, F3, F2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to bleeding disorder:

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MGI Mouse Phenotypes related to bleeding disorder:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	9.0	ZP1, OCRL, THBS1, TBXA2R, PTGS1, F10
2	hematopoietic system phenotype	MP:0005397	8.6	PLEK, TBXAS1, TUBB1, F13A1, F11, GP1BA
3	immune system phenotype	MP:0005387	8.5	PTGS1, TBXA2R, TBXAS1, THBS1, HSPG2, F11
4	homeostasis/metabolism phenotype	MP:0005376	INF	ADRA2A, F3, F2, F10, F11, F12
5	cardiovascular system phenotype	MP:0005385	INF	HSPG2, F13A1, F11, F10, PTGS1, TBXA2R
6	mortality/aging	MP:0010768	INF	F10, F11, F13A1, HSPG2, PTGS1, TBXA2R

Articles related to bleeding disorder:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Diagnosis and management of bleeding disorder in a ch ild. (20118083)	Sarnaik A.... Kannikeswaran N.	2010	F2, F3
2	Study of 18 functional hemostatic polymorphisms in mu cocutaneous bleeding disorders. (20532885)	AntA^n A.I.... Mezzano D.	2010	SERPINE1, F2, ANXA5
3	Bleeding disorders in Lowe syndrome patients: evidenc e for a link between OCRL mutations and primary haemostasis disorders. (20629659)	Lasne D.... Bachelot-Loza C.	2010	OCRL
4	Introduction. Rare bleeding disorders: general aspect s of clinical features, diagnosis, and management. (19598063)	Peyvandi F.... Mannucci P.M.	2009	F10, F8, F11
5	Impaired platelet procoagulant mechanisms in patients with bleeding disorders. (19408196)	Weiss H.J.	2009	F10, F5
6	A compound heterozygous mutation in glycoprotein VI i n a patient with a bleeding disorder. (19552682)	Hermans C.... Freson K.	2009	CRP, GP6
7	The value of proteomics for the diagnosis of a platelet-related bleeding disorder. (18791940)	Maurer-Spurej E.... Cyr T.D.	2008	THBS1
8	Congenital bleeding disorders of the vitamin K-dependent clotting factors. (18374200)	Girolami A.... Vettore S.	2008	F9, F2
9	Inherited bleeding disorders: a 14-year retrospective study. (19174980)	Eid S.S.... Wael A.G.	2008	F11
10	Rare bleeding disorders. (18510543)	Peyvandi F.... Spreafico M.	2008	F10, F8, F11
11	The prevalence of bleeding disorders among healthy pediatric patients with abnormal preprocedural coagulation studies. (18376266)	Shaw P.H.... Ritchey A.K.	2008	F2, F3
12	Evaluation of desmopressin effects on haemostasis in children with congenital bleeding disorders. (18284449)	Hanebutt F.L.... Knoefler R.	2008	VWF, F8
13	Antiviral therapy for chronic hepatitis C in patients with inherited bleeding disorders: an international, multicenter cohort study. (17663735)	Posthouwer D.... Mauser-Bunschoten E.P.	2007	IFNA1
14	Factor V Leiden--dental patient management for a rare bleeding disorder: a case report. (17444259)	Cohen H.V.	2007	F5
15	Pregnancy and oral contraceptives in congenital bleeding disorders of the vitamin K-dependent coagulation factors. (16424651)	Girolami A.... Fabris F.	2006	F2, F11
16	Genetic diagnosis of haemophilia and other inherited bleeding disorders. (16684001)	Peyvandi F.... Mannucci P.M.	2006	F9, F8
17	Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency. (16181984)	Dargaud Y.... Negrier C.	2005	PTGS1
18	Influence of factor V HR2 on thrombin generation and clinical manifestation in rare bleeding disorders. (16772740)	Strey R.F.... Herrmann F.H.	2005	F5
19	Congenital deficiencies of coagulation factors and acquired inhibitors leading to bleeding disorders (15526067)	Meili E.O.	2004	F5
20	Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X, XIII, fibrinogen and dysfibrinogenemias. (14995986)	Acharya S.S.... DiMichele D.M.	2004	F10
21	Esophageal bleeding disorders. (15703670)	Wu J.C.... Chan F.K.	2004	SST
22	Modern management of bleeding disorders and haemorrhage in otorhinolaryngology (14634891)	Delank K.W.	2003	F3
23	Transjugular liver biopsy is safe and diagnostic for patients with congenital bleeding disorders and hepatitis C infection. (14511303)	DiMichele D.M.... Talal A.H.	2003	F5
24	Inherited bleeding disorders in Indian women with menorrhagia. (12614371)	Saxena R.... Bhargava M.	2003	F2, F3
25	A randomized study of alpha-interferon plus ribavirin for 6 months or 12 months for the treatment of chronic hepatitis C in patients with bleeding disorders. (11952848)	Schulman S.... von Sydow M.	2002	IFNA2
26	Gene therapy for bleeding disorders. (12394174)	Manno C.S.	2002	F9
27	Characterization of a novel autosomal dominant bleeding disorder in a large kindred from east Texas. (11238089)	Kuang S.Q.... Milewicz D.M.	2001	BDET
28	Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits. (11228339)	Elg M.... Gustafsson D.	2001	VWF, F9
29	Inherited bleeding disorders in dermatologic surgery. (11722527)	Peterson S.R.... Joseph A.K.	2001	F9
30	Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. (11442478)	Dube J.N.... Laneuville O.	2001	PTGS1
31	Acquired bleeding disorder in a patient with malignant lymphoma: antibody-mediated prothrombin deficiency. (11241228)	Lee E.S.... Liebman H.A.	2001	F2
32	Liver biopsy in Irish hepatitis C-infected patients with inherited bleeding disorders. (10848824)	McMahon C.... Smith O.P.	2000	F9, F8
33	Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders. (10215946)	Kadir R.A.... Lee C.A.	1999	F11
34	Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. (10097136)	Wang L.... Verma I.M.	1999	F9
35	Desmopressin (DDAVP) in bleeding disorders of childhood. (10066151)	Sutor A.H.	1998	VWF
36	Quality of life during menstruation in patients with inherited bleeding disorders. (10028306)	Kadir R.A.... Economides D.L.	1998	F11
37	Defective signal transduction through the thromboxane A2 receptor in a patient with a mild bleeding disorder: deficiency of the inositol 1,4,5-triphosphate formation despite normal G-protein activation. (9184416)	Mitsui T.... Hayasaka K.	1997	TBXA2R
38	Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder. (9136969)	Colwell N.S.... Blinder M.A.	1997	SERPINC1
39	A long-term follow-up study of interferon treatment for chronic hepatitis C in Japanese patients with congenital bleeding disorders. (8856094)	Yamada M.... Hayakawa T.	1996	IFNA1
40	Bleeding disorder due to platelet prostaglandin H synthase-1 (PGHS-1) deficiency. (8562397)	Matijevic-Aleksic N.... Wu K.K.	1996	PTGS1, TBXAS1
41	Hereditary bleeding disorders in Riyadh, Saudi Arabia . (17372424)	al-Fawaz I.M.... Harakati M.S.	1996	F5
42	The pathophysiology of bleeding disorders presenting as abnormal uterine bleeding. (8828560)	Ewenstein B.M.	1996	SERPINE1, F2, F3
43	Homozygosity for a novel missense mutation in the prothrombin gene causing a severe bleeding disorder. (7740448)	Poort S.R.... Bertina R.M.	1994	F2
44	Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. (7929844)	Hirata T.... Narumiya S.	1994	TBXA2R
45	Homologous recombination among three intragene Alu sequences causes an inversion-deletion resulting in the hereditary bleeding disorder Glanzmann thrombasthenia. (8317479)	Li L.... Bray P.F.	1993	ITGA2B, ITGB3
46	Rare inherited bleeding disorders secondary to coagul ation factors in Jordan: a nine-year study. (1414155)	Awidi A.S.	1992	F5
47	Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome. (1730083)	Bevers E.M.... Sims P.J.	1992	F10, TNXA
48	A lifelong bleeding disorder associated with a deficiency of plasminogen activator inhibitor type 1. (1899347)	DiAcval J.... Kruithof E.K.	1991	SERPINE1
49	Bleeding disorder (von Willebrand disease) in a quarter horse. (1995565)	Brooks M.... Dodds W.J.	1991	VWF
50	Mutation of antitrypsin to antithrombin. Alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. (6604220)	Owen M.C.... Carrell R.W.	1983	SERPINA1

Genes related to bleeding disorder according to GeneCards:

(show top 50)    (show all 51)

id	Symbol	Description	Score	GeneCards Section Context
1	BDET	Bleeding disorder, east Texas type	11.1	Aliases & Descriptions, Publications
2	TBXA2R	thromboxane A2 receptor	11.1	Publications, Summaries
3	GP5	glycoprotein V (platelet)	11.1	Summaries
4	MCFD2	multiple coagulation factor deficiency 2	11.1	Summaries, Publications
5	GP6	glycoprotein VI (platelet)	11.1	Publications, Summaries
6	MMRN1	multimerin 1	11.1	Summaries
7	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.1	Publications, Summaries
8	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	11.0
9	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	11.0
10	ZP1	zona pellucida glycoprotein 1 (sperm receptor)	11.0	Publications
11	F11	coagulation factor XI	11.0	Publications
12	TNXA	tenascin XA (pseudogene)	11.0	Publications
13	FERMT3	fermitin family member 3	11.0
14	F9	coagulation factor IX	11.0	Publications
15	HABP2	hyaluronan binding protein 2	11.0	Publications
16	OCRL	oculocerebrorenal syndrome of Lowe	11.0	Publications
17	F12	coagulation factor XII (Hageman factor)	11.0	Publications
18	LMAN1	lectin, mannose-binding, 1	11.0	Publications
19	TUBB1	tubulin, beta 1 class VI	11.0	Publications
20	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
21	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	Publications
22	VKORC1	vitamin K epoxide reductase complex, subunit 1	11.0	Publications
23	ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	11.0	Publications
24	F10	coagulation factor X	11.0	Publications
25	CFI	complement factor I	11.0	Publications
26	ADRA2A	adrenoceptor alpha 2A	11.0	Publications
27	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
28	F2	coagulation factor II (thrombin)	11.0	Publications
29	ANO6	anoctamin 6	11.0
30	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
31	PLEK	pleckstrin	11.0	Publications
32	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
33	F8	coagulation factor VIII, procoagulant component	11.0	Publications
34	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
35	THBS1	thrombospondin 1	11.0	Publications
36	VWF	von Willebrand factor	11.0	Publications
37	TBXAS1	thromboxane A synthase 1 (platelet)	11.0	Publications
38	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
39	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
40	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
41	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
42	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
43	IFNA2	interferon, alpha 2	11.0	Publications
44	ANXA5	annexin A5	11.0	Publications
45	SST	somatostatin	11.0	Publications
46	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
47	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
48	KLK3	kallikrein-related peptidase 3	11.0	Publications
49	IFNA1	interferon, alpha 1	11.0	Publications
50	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to bleeding disorder according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Gamma-carboxylation of protein precursors38	10.2	F9, F10
2	Cell adhesion_Integrin inside-out signaling41	10.1	ITGA2, ITGB3, TBXA2R
3	Warfarin Pathway, Pharmacodynamics34	9.9	F10, F2, F7, F9, VKORC1
4	Cell adhesion Integrin inside-out signaling10	9.9	TBXA2R, F2, ITGB3, ITGA2B, ITGA2
5	Common Pathway38	9.7	SERPINC1, F5, F13A1
6	Hematopoietic cell lineage20	9.7	GP1BA, GP5, ITGB3, ITGA2B, ITGA2
7	Response to elevated platelet cytosolic Ca2+38	9.6	THBS1, PLEK, F8, MMRN1, SERPINA1, SERPINF2
8	ECM-receptor interaction20	9.2	THBS1, HSPG2, GP6, GP1BA, GP5, ITGB3
9	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.1	TBXAS1, TBXA2R, PTGS1, F2, GP6, GP5
10	Extrinsic Prothrombin Activation Pathway36	9.0	F13A1, F12, F10, F2, F3, F5
11	Selected targets of HNF110	8.6	SERPINA1, F8, F13A1, CRP
12	Intrinsic Prothrombin Activation Pathway36	8.5	KLK3, F13A1, F12, F11, F10, F2
13	Blood Coagulation Cascade36	8.1	F9, SERPINC1, F8, F7, F5, KLK3
14	UPA-UPAR Pathway36	INF	, HSPG2, ITGB3, ITGA2B, ITGA2, SERPINE1
15	Blood Coagulation Signaling Pathways37	INF	VWF, F11, F10, F2, F3, F5
16	Complement and coagulation cascades20	INF	, F13A1, F12, F11, F10, F2

Compounds related to bleeding disorder according to GeneDecks:

(show top 50)    (show all 242)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.5	F8, F9
2	clopidogrel32 34 9 18 9	13.9	SERPINC1, P2RY12, F10, TNXA, PTGS1, TBXA2R
3	kaolin32	9.7	F9, F8, F5, F3, F2, F12
4	coumarins32	9.6	F10, F2, F3, F5, F9, VKORC1
5	gamma-carboxyglutamic acid32	9.5	TNXA, F10, F2, F3, F7, F9
6	rfviii32	9.5	F5, F8, F9, VWF, F10
7	danaparoid32	9.5	SERPINC1, F5, F3, F2, F10, TNXA
8	thromboxane32 18	10.5	VWF, PLEK, TBXA2R, PTGS1, GP6, ITGA2
9	fondaparinux32	9.5	F5, TNXA, F9, SERPINC1, F3, F2
10	bivalirudin32 9 9	11.4	F5, SERPINC1, F3, F2, F10, TNXA
11	phosphatidylserine32 9 9	11.4	PLEK, THBS1, TNXA, F10, F2, VWF
12	ristocetin32	9.3	VWF, SERPINC1, SERPINF2, GP1BA, GP6, F9
13	argatroban32 9 9	11.3	F10, F5, F3, F2, TNXA, SERPINC1
14	ecarin32	9.3	F2, F10, F5, F3, SERPINC1
15	ppack32	9.3	VWF, F10, F2, F3, P2RY12, SERPINC1
16	heparinoids32	9.2	F5, F3, F2, F10, SERPINC1, F13A1
17	thromboxane a232 18	10.1	VWF, P2RX1, P2RY12, ITGA2, GP6, F8
18	convulxin32	9.0	ITGA2, GP1BA, GP6, F5, F10, HSPG2
19	spectrozyme32	9.0	F10, SERPINC1, F5, F3, F2
20	warfarin32 34 9 18 9	12.8	VWF, SERPINC1, VKORC1, MCFD2, F9, F8
21	coumarin32 18	9.8	F9, VKORC1, SERPINC1, F5, F3, F2
22	abciximab32 9 9	10.8	CRP, F10, F2, F3, VWF, ITGA2B
23	phospholipid32	8.1	VWF, SERPINA1, ITGA2, ANXA5, F9, F8
24	tirofiban32 9 9	10.0	VWF, SERPINC1, P2RY12, ITGA2, ITGA2B, ITGB3
25	homocysteine32 18	8.7	F9, F5, F3, F2, VWF, F11
26	adp32 18	8.6	F10, GP6, SERPINF2, P2RX1, P2RY12, ITGA2
27	lipid32	6.3	ADRA2A, OCRL, THBS1, TBXA2R, PLEK, CRP
28	calcium32 9 18 9	8.3	ANXA5, ADRA2A, F5, GP1BA, MCFD2, HABP2
29	aspirin32 34 18	INF	VWF, SERPINC1, SERPINE1, TBXA2R, TBXAS1, CRP
30	desmopressin32 42 9 9	INF	PTGS1, , VWF, SERPINC1, SERPINF2, SERPINE1
31	epsilon aminocaproic acid32	INF	THBS1, , F9, SERPINE1, SERPINF2, F3
32	cysteine32	INF	PTGS1, IFNA2, ITGA2B, P2RX1, SERPINA1, GP6
33	vegf32	INF	VWF, SERPINC1, SERPINF2, SERPINE1, ITGA2, ITGB3
34	dextran sulfate32	INF	HABP2, THBS1, KLK3, , F10, F3
35	epinephrine32 9 18 9	INF	SERPINF2, P2RY12, ADRA2A, KLK3, ITGA2, GP1BA
36	prostacyclin32	INF	F8, F5, F3, HSPG2, PTGS1, TBXA2R
37	alanine32	INF	SERPINC1, F10, HSPG2, TNXA, PTGS1, CRP
38	polysaccharide32	INF	LMAN1, KLK3, SERPINC1, SERPINF2, , TNXA
39	hirudin32	INF	SERPINC1, SERPINF2, GP1BA, F9, F5, F10
40	estrogen32	INF	ITGB3, F9, F8, F5, IFNA2, VWF
41	aspartate32	INF	F9, F8, F7, F5, F2, F10
42	fibrinogen32	INF	GP1BA, GP5, ANXA5, MMRN1, ITGB3, ITGA2B
43	kininogen32	INF	THBS1, HABP2, , F13A1, F12, VWF
44	creatinine32	INF	VWF, SERPINC1, SERPINA1, OCRL, , CRP
45	dermatan sulfate32	INF	, VWF, SERPINC1, F9, F5, F3
46	heparin32 9 18 9	INF	VWF, TBXA2R, , HABP2, TNXA, HSPG2
47	tranexamic acid32 9 9	INF	VWF, SERPINC1, SERPINE1, F9, F8, F3
48	aprotinin32 9 9	INF	VWF, SERPINC1, SERPINF2, GP1BA, F9, F5
49	serine32	INF	F10, HABP2, THBS1, ABO, F11, F12
50	lysine32	INF	SERPINA1, SERPINF2, LMAN1, P2RX1, F13A1, TNXA

Cellular components related to bleeding disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	9.5	HSPG2, F10, F2, F7, F9
2	external side of plasma membrane	GO:009897	9.5	VWF, ITGA2, ITGA2B, ANXA5, THBS1
3	extracellular matrix	GO:031012	8.7	THBS1, HSPG2, F3, SERPINE1, VWF
4	platelet alpha granule lumen	GO:031093	8.5	THBS1, F13A1, F5, F8, MMRN1, SERPINE1
5	extracellular region	GO:005576	INF	HABP2, F11, F12, F13A1, HSPG2, SST
6	extracellular space	GO:005615	INF	F11, F12, HSPG2, SST, CRP,
7	plasma membrane	GO:005886	INF	F11, F10, F2, F3, F5, F12

Biological processes related to bleeding disorder according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet aggregation	GO:070527	10.1	ITGB3, FERMT3, PLEK
2	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:010641	10.1	F3, F7
3	blood coagulation, extrinsic pathway	GO:007598	10.1	F10, F3, F7, F9
4	peptidyl-glutamic acid carboxylation	GO:017187	10.1	VKORC1, F9, F7, F2, F10
5	activation of blood coagulation via clotting cascade	GO:002543	10.0	F3, ANO6
6	negative regulation of plasminogen activation	GO:010757	9.9	THBS1, SERPINE1, SERPINF2
7	negative regulation of fibrinolysis	GO:051918	9.8	THBS1, F2, SERPINE1, SERPINF2
8	post-translational protein modification	GO:043687	9.8	F10, F2, F7, F9, MCFD2, LMAN1
9	positive regulation of protein kinase B signaling cascade	GO:051897	9.8	F7, F3, F10, THBS1
10	integrin-mediated signaling pathway	GO:007229	9.7	PLEK, ITGB3, ITGA2B, ITGA2
11	positive regulation of blood coagulation	GO:030194	9.7	THBS1, F12, F2, F7, SERPINE1
12	positive regulation of cell migration	GO:030335	9.7	ADRA2A, THBS1, F10, F3, F7
13	cellular protein metabolic process	GO:044267	9.7	TUBB1, F10, F2, F7, F9, MCFD2
14	cell-matrix adhesion	GO:007160	9.6	GP5, ITGB3, ITGA2B, ITGA2
15	blood coagulation, intrinsic pathway	GO:007597	9.6	F12, F11, F10, F2, F8, F9
16	positive regulation of angiogenesis	GO:045766	9.5	SERPINE1, F3, TBXA2R, THBS1
17	acute-phase response	GO:006953	9.2	CRP, F2, F8, SERPINA1, SERPINF2
18	cell adhesion	GO:007155	9.1	HABP2, THBS1, F5, F8, GP1BA, GP5
19	platelet degranulation	GO:002576	8.3	VWF, SERPINF2, SERPINA1, SERPINE1, THBS1, PLEK
20	platelet activation	GO:030168	6.9	ADRA2A, THBS1, PLEK, TBXA2R, F13A1, F2
21	fibrinolysis	GO:042730	INF	, F12, F2, GP1BA, SERPINE1, SERPINF2
22	blood coagulation	GO:007596	INF	VWF, GP6, GP1BA, GP5, ANXA5, MMRN1
23	proteolysis	GO:006508	INF	HABP2, KLK3, , F12, F11, F10

Molecular functions related to bleeding disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen binding	GO:005518	9.9	GP6, GP5, ITGA2, VWF
2	eukaryotic cell surface binding	GO:043499	9.5	SERPINF2, ANXA5, THBS1
3	serine-type endopeptidase inhibitor activity	GO:004867	9.2	SERPINC1, SERPINF2, SERPINA1, SERPINE1
4	protease binding	GO:002020	8.8	F3, SERPINE1, SERPINA1, SERPINF2, SERPINC1, VWF
5	serine-type endopeptidase activity	GO:004252	INF	CFI, HABP2, KLK3, , F12, F11
6	protein binding	GO:005515	INF	F2, F10, F11, F12, HSPG2, TBXA2R