MCID: BLP005
MIFTS: 42

Blepharitis malady

Eye diseases category

Summaries for Blepharitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Blepharitis (/blɛfərˈaɪtɨs/ BLEF-ər-EYE-tis) is an eye condition characterized by chronic... more...

MalaCards: Blepharitis is related to conjunctivitis and ulcerative blepharitis. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways is Spinal Cord Injury. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Aliases & Classifications for Blepharitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

blepharitis 8 10 44 60


Related Diseases for Blepharitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Blepharitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.4
2ulcerative blepharitis10.3
3herpes simplex10.2
4lupus erythematosus10.2
5rosacea10.1
6squamous blepharitis10.1
7blepharoconjunctivitis10.1
8keratosis follicularis spinulosa decalvans, x-linked10.1
9gingivitis10.0LTF
10otitis media10.0LTF
11sjogren's syndrome10.0LTF
12keratoconjunctivitis sicca10.0LTF
13amyloidosis10.0LYZ
14strongyloidiasis10.0SHE
15keratosis follicularis spinulosa decalvans10.0SAT1
16ulcerative colitis10.0LYZ, LTF
17pleurisy10.0PLA2G6
18periodontal disease10.0LYZ, LTF, CST4
19peritonitis10.0PLA2G6
20keratosis follicularis10.0MBTPS2, SAT1
21crohn's disease10.0LTF, LYZ
22pulmonary emphysema10.0MMP9
23periodontitis10.0MMP9
24hypersensitivity reaction type ii disease10.0LTF, LYZ
25acne10.0
26allergic conjunctivitis10.0
27bacterial conjunctivitis10.0
28dermatitis10.0
29eye disease10.0
30leukonychia totalis10.0
31odontoonychodermal dysplasia10.0
32epidermolysis bullosa dystrophica, ar10.0
33xeroderma pigmentosum, group a10.0
34sarcoidosis10.0IFNG, LYZ
35fibrosarcoma10.0MMP9
36meningitis10.0MMP9, LYZ
37septic shock10.0PLA2G1B, LTF, PLA2G6
38monocytic leukemia10.0IFNG, LTF
39acute pancreatitis10.0PLA2G1B, PLA2G6, SAT1
40tropical spastic paraparesis10.0IFNG, MMP9
41relapsing-remitting multiple sclerosis10.0IFNG, MMP9
42atherosclerosis10.0LIPA, PLA2G1B, PLA2G6, MMP9
43arthritis10.0LYZ, PLA2G1B, PLA2G6, MMP9, IFNG, LTF
44sjogren-larsson syndrome9.8
45nodular nonsuppurative panniculitis9.8
46relapsing polychondritis9.8
47melkersson-rosenthal syndrome9.8
48junctional epidermolysis bullosa9.8
49ladd syndrome9.8
50sea-blue histiocyte syndrome9.8

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Clinical Features for Blepharitis

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Drugs & Therapeutics for Blepharitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Blepharitis

Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Search CenterWatch for Blepharitis

Genetic Tests for Blepharitis

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Anatomical Context for Blepharitis

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32MalaCards
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MalaCards organs/tissues related to Blepharitis:

32
Eye, Skin, Testes

Animal Models for Blepharitis or affiliated genes

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Publications for Blepharitis

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50PubMed
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Articles related to Blepharitis:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. (23565576)
2013
2
A novel gammaherpesvirus in a large flying fox (Pteropus vampyrus) with blepharitis. (23628640)
2013
3
Assessment of the tolerability profile of an ophthalmic solution of 5% glycyrrhizin and copolymer PEG/PPG on healthy volunteers and evaluation of its efficacy in the treatment of moderate to severe blepharitis. (23874081)
2013
4
Comparative ocular microbial communities in humans with and without blepharitis. (22836761)
2012
5
Ambient levels of air pollution induce clinical worsening of blepharitis. (22204918)
2012
6
Interventions for chronic blepharitis. (22592706)
2012
7
Role of Demodex folliculorum in the pathogenesis of blepharitis. (22429751)
2012
8
Successful treatment of blepharitis with bibrocathol (PosiforminAr 2 %). (22527308)
2012
9
18I^-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis. (21426233)
2011
10
Azithromycin in DuraSite for the treatment of blepharitis. (20689782)
2010
11
Diagnosis and treatment of demodectic blepharitis. (19367544)
2009
12
Treatment of Malassezia species associated seborrheic blepharitis with fluconazole. (19957565)
2009
13
Use of azithromycin ophthalmic solution in the treatment of chronic mixed anterior blepharitis. (19013912)
2008
14
Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis with cylindrical dandruff. (17592319)
2007
15
Discoid lupus erythematosus of the eyelids associated with staphylococcal blepharitis and Meibomian gland dysfunction. (16309490)
2006
16
Mycotic blepharitis associated with Fusarium species in a Eurasian eagle owl (Bubo bubo hispanus). (17114385)
2006
17
Discoid lupus erythematosus presenting as unilateral blepharitis. (16714936)
2006
18
Blepharitis induced by epidermal growth factor receptor-targeting therapy. (17023793)
2006
19
Kaposi varicelliform eruption associated with 0.1% tacrolimus ointment treatment in atopic blepharitis. (15075889)
2004
20
Monthly recurrent herpes simplex virus blepharitis in a boy for more than 10 years. (14562953)
2003
21
Effects of minocycline on the ocular flora of patients with acne rosacea or seborrheic blepharitis. (12883348)
2003
22
A case of seborrheic blepharitis; treatment with itraconazole. (12145635)
2002
23
Meibomian secretions in chronic blepharitis. (9634903)
1998
24
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
25
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. (8694093)
1996
26
Unilateral Malassezia furfur blepharitis after perforating keratoplasty. (8695578)
1996
27
A comparative study of eyelid cleaning regimens in chronic blepharitis. (8828939)
1996
28
Phthiriasis palpebrarum: an unusual course of blepharitis. (7767432)
1995
29
Chronic blepharitis: a review. (7586480)
1995
30
An in vitro comparison of the susceptibilities of bacterial isolates from patients with conjunctivitis and blepharitis to newer and established topical antibiotics. (7671609)
1995
31
Chronic blepharitis: easy nursing interventions for a common problem. (1542124)
1992
32
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
33
Unilateral chronic granulomatous blepharitis as a leading symptom of Oriental cutaneous leishmaniasis in Germany. Giesma stain as rapid diagnosis and initial description of systemic therapy with gamma-interferon]. (1578880)
1992
34
Blepharitis. (1460262)
1992
35
The role of wax and sterol ester fatty acids in chronic blepharitis. (2032812)
1991
36
Suppurative conjunctivitis and ulcerative blepharitis in 129/J mice. (1666162)
1991
37
Tear cholesterol levels in blepharitis. (2090980)
1990
38
A rabbit model of staphylococcal blepharitis. (3827720)
1987
39
Eyelid problems. Blepharitis, hordeola, and chalazia. (3737498)
1986
40
Microbial and immunological investigations of chronic non-ulcerative blepharitis and meibomianitis. (4016059)
1985
41
Phthirus pubis (pubic louse) blepharitis. (6208777)
1984
42
Comparative bacteriology of chronic blepharitis. (6743618)
1984
43
Staphylococcal bacterin for treatment of chronic staphylococcal blepharitis in the dog. (6469840)
1984
44
Blepharitis granulomatosa. (6476853)
1984
45
Blepharitis by Microsporum canis. (6093916)
1983
46
Treatment of blepharitis and blepharoconjunctivitis: comparison of gentamicin-betamethasone, gentamicin alone and placebo. (6751510)
1982
47
Demodex: a cause of blepharitis in Australia. (5797166)
1969
48
The treatment of seborrheic blepharitis. (13186953)
1954
49
Observations on Pityrosporum ovale in seborrheic blepharitis and conjunctivitis. (20273107)
1947
50
Chronic Blepharitis in Children: Treatment with Aniline Dye Compound. (20783235)
1940

Genetic Variations for Blepharitis

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Expression for genes affiliated with Blepharitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

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37NCBI BioSystems Database
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Pathways related to Blepharitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLA2G6, MMP9

Compounds for genes affiliated with Blepharitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Blepharitis according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tranilast4410.0MMP9, IFNG
2scalaradial4410.0PLA2G1B, PLA2G6
3manoalide449.9PLA2G1B, PLA2G6
4succinate449.9PLA2G6, MMP9, LTF
5p-bromophenacyl bromide449.9PLA2G1B, PLA2G6
6ribavirin44 49 1111.9IFNG, LTF, MMP9
7melittin449.9PLA2G1B, PLA2G6
8Alpha-D-Mannose119.8LYZ, PLA2G1B, LTF
9lysophospholipid449.8PLA2G1B, PLA2G6
10aacocf3449.7PLA2G6, PLA2G1B
11hydrocortisone44 2 59 1112.6PLA2G6, LTF, IFNG
12aristolochic acid44 210.6PLA2G1B, PLA2G6
13leukotriene b444 59 2411.6PLA2G1B, MMP9, LTF
14simvastatin44 49 59 28 11 2414.5MMP9, LIPA, IFNG
15sb 20358044 5910.4IFNG, SAT1, MMP9, PLA2G6
16ltd4449.3PLA2G1B, PLA2G6
17indomethacin44 59 28 1112.3IFNG, LTF, PLA2G6, PLA2G1B
18actinomycin d449.3IFNG, SAT1, LTF, MMP9, PLA2G6
19cyclosporin a44 28 5911.1IFNG, LTF, MMP9, PLA2G6
20dexamethasone44 49 28 1111.9IFNG, LTF, MMP9, PLA2G6, PLA2G1B
21pge2448.7PLA2G1B, PLA2G6, MMP9, LTF, SAT1, IFNG

GO Terms for genes affiliated with Blepharitis

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16Gene Ontology
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Cellular components related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.0LACRT, PLA2G1B, LTF
2extracellular regionGO:0055767.9CST4, LTF, MMP9, PLA2G1B, LACRT, LYZ

Biological processes related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G1B, PLA2G6
2defense response to bacteriumGO:0427429.3LYZ, LTF, IFNG
3endoplasmic reticulum unfolded protein responseGO:0309689.3MBTPS2, IFNG, WIPI1

Molecular functions related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blepharitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet