MCID: BLP005
MIFTS: 39

Blepharitis malady

Eye category

Summaries for Blepharitis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Blepharitis (/blɛfərˈaɪtɨs/ BLEF-ər-EYE-tis) is an eye condition characterized by chronic... more...

MalaCards: Blepharitis is related to ulcerative blepharitis and rosacea. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways is Spinal Cord Injury. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Blepharitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

blepharitis 8 10 45 61


Related Diseases for Blepharitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Blepharitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative blepharitis10.3
2rosacea10.2
3squamous blepharitis10.2
4discoid lupus erythematosus10.2
5blepharoconjunctivitis10.1
6keratosis follicularis spinulosa decalvans, x-linked10.1
7eye carcinoma10.0
8eyelid carcinoma10.0
9acne10.0
10bacterial conjunctivitis10.0
11leukonychia totalis10.0
12odontoonychodermal dysplasia10.0
13epidermolysis bullosa dystrophica, ar10.0
14xeroderma pigmentosum, group a10.0
15gingivitis10.0LTF
16otitis media10.0LTF
17sjogren's syndrome10.0LTF
18keratoconjunctivitis sicca10.0LTF
19amyloidosis10.0LYZ
20strongyloidiasis10.0SHE
21keratosis follicularis spinulosa decalvans10.0SAT1
22ulcerative colitis10.0LYZ, LTF
23pleurisy10.0PLA2G6
24periodontal disease10.0CST4, LTF, LYZ
25peritonitis10.0PLA2G6
26keratosis follicularis10.0SAT1, MBTPS2
27crohn's disease10.0LTF, LYZ
28pulmonary emphysema10.0MMP9
29periodontitis10.0MMP9
30hypersensitivity reaction type ii disease10.0LYZ, LTF
31sarcoidosis10.0LYZ, IFNG
32fibrosarcoma10.0MMP9
33meningitis10.0LYZ, MMP9
34septic shock10.0LTF, PLA2G6, PLA2G1B
35monocytic leukemia10.0LTF, IFNG
36acute pancreatitis10.0PLA2G1B, PLA2G6, SAT1
37tropical spastic paraparesis10.0MMP9, IFNG
38relapsing-remitting multiple sclerosis10.0MMP9, IFNG
39atherosclerosis10.0LIPA, MMP9, PLA2G6, PLA2G1B
40arthritis10.0IFNG, LTF, MMP9, PLA2G6, PLA2G1B, LYZ
41sjogren-larsson syndrome9.9
42nodular nonsuppurative panniculitis9.9
43relapsing polychondritis9.9
44melkersson-rosenthal syndrome9.9
45junctional epidermolysis bullosa9.9
46ladd syndrome9.9
47sea-blue histiocyte syndrome9.9
48juvenile xanthogranuloma9.9
49aniridia9.9
50crimean-congo hemorrhagic fever9.9

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Clinical Features for Blepharitis

Drugs & Therapeutics for Blepharitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Blepharitis

Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Search CenterWatch for Blepharitis

Genetic Tests for Blepharitis

Anatomical Context for Blepharitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Blepharitis:

33
Skin

Animal Models for Blepharitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Blepharitis

Sources:
51PubMed
See all sources

Articles related to Blepharitis:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Ethyl ether: an old ally against oral ivermectin resistant demodex blepharitis. (24269425)
2013
2
A novel gammaherpesvirus in a large flying fox (Pteropus vampyrus) with blepharitis. (23628640)
2013
3
Severe chronic blepharitis and scarring ectropion associated with discoid lupus erythematosus. (22845188)
2013
4
Chronic blepharitis. (23799315)
2013
5
Interventions for chronic blepharitis. (22592706)
2012
6
Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis. (23255861)
2012
7
Blepharitis. (22623633)
2012
8
The efficacy of oral ivermectin for the treatment of chronic blepharitis in patients tested positive for Demodex spp. (21349944)
2011
9
Chronic blepharitis caused by Demodex folliculorum mites. (19291177)
2009
10
Trace elements and blepharitis. (19356972)
2009
11
Tear and meibomian gland function in blepharitis and normals. (19516145)
2009
12
Diabetes as a possible predisposer for blepharitis. (18711470)
2008
13
Blepharitis: current strategies for diagnosis and management. (18347619)
2008
14
Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. (18781287)
2008
15
Prevalence and treatment of Helicobacter pylori in patients with blepharitis. (16431942)
2006
16
Monthly recurrent herpes simplex virus blepharitis in a boy for more than 10 years. (14562953)
2003
17
N-acetylcysteine in chronic blepharitis. (11862087)
2002
18
Changing concepts in the diagnosis and management of blepharitis. (11009317)
2000
19
Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients. (10509674)
1999
20
Slime production by coagulase-negative staphylococci isolated in chronic blepharitis. (9590586)
1998
21
Experiences in treating patients for blepharitis. (9715707)
1998
22
Discoid lupus erythematosus presenting as asymmetric posterior blepharitis. (9372736)
1997
23
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. (8694093)
1996
24
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
25
Phthiriasis palpebrarum: an unusual course of blepharitis. (7767432)
1995
26
Clinical diagnosis of recurrent herpes simplex blepharitis in an adult: a case report. (8014364)
1994
27
Coagulase-negative staphylococci in conjunctivitis and blepharitis. (8168607)
1993
28
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
29
Unilateral chronic granulomatous blepharitis as a leading symptom of Oriental cutaneous leishmaniasis in Germany. Giesma stain as rapid diagnosis and initial description of systemic therapy with gamma-interferon]. (1578880)
1992
30
Blepharitis. (1460262)
1992
31
The role of tetracycline in chronic blepharitis. Inhibition of lipase production in staphylococci. (1917401)
1991
32
Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis. (2344168)
1990
33
Management of chronic blepharitis. (2546524)
1989
34
The role of wax and sterol esters of meibomian secretions in chronic blepharitis. (2777516)
1989
35
Experience with a new detergent lid scrub in the management of chronic blepharitis. (3369982)
1988
36
Bacterial lipases and chronic blepharitis. (3957566)
1986
37
Methicillin-resistant Staphylococcus epidermidis blepharitis. (6568091)
1984
38
Opticrom in the management of blepharitis. (6443720)
1984
39
Comparative bacteriology of chronic blepharitis. (6743618)
1984
40
Blepharitis and secondary conjunctivitis. (7369329)
1980
41
Recurrent herpetic angular blepharitis in an adult. (507148)
1979
42
Staphylococcal blepharitis. (324453)
1977
43
The masked rat. An X-ray induced mutant with chronic blepharitis, alopecia, and pasteurellosis. (1262697)
1976
44
Effect of blephamide in blepharitis. (4666812)
1972
45
Demodex folliculorum blepharitis. (4229846)
1967
46
Pityrosporum orbiculare. Its possible role in seborrheic blepharitis. (4225663)
1967
47
TREATMENT OF BLEPHARITIS. (14273035)
1965
48
Use of selsun in blepharitis marginalis. (13197513)
1954
49
The treatment of blepharitis. (14869654)
1951
50
THE SIGNIFICANCE OF ERRORS OF REFRACTION IN CHRONIC BLEPHARITIS OF CHILDREN. (18169606)
1939

Genetic Variations for Blepharitis

Expression for genes affiliated with Blepharitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Blepharitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLA2G6, MMP9

Compounds for genes affiliated with Blepharitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB, 29IUPHAR
See all sources

Compounds related to Blepharitis according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tranilast4510.0MMP9, IFNG
2scalaradial4510.0PLA2G1B, PLA2G6
3manoalide459.9PLA2G1B, PLA2G6
4succinate459.9PLA2G6, MMP9, LTF
5p-bromophenacyl bromide459.9PLA2G1B, PLA2G6
6ribavirin45 50 1111.9IFNG, LTF, MMP9
7melittin459.9PLA2G1B, PLA2G6
8Alpha-D-Mannose119.8LYZ, PLA2G1B, LTF
9lysophospholipid459.8PLA2G1B, PLA2G6
10aacocf3459.7PLA2G6, PLA2G1B
11hydrocortisone45 2 60 1112.6PLA2G6, LTF, IFNG
12aristolochic acid45 210.6PLA2G1B, PLA2G6
13leukotriene b445 60 2411.6PLA2G1B, MMP9, LTF
14simvastatin45 50 60 29 11 2414.5MMP9, LIPA, IFNG
15sb 20358045 6010.4IFNG, SAT1, MMP9, PLA2G6
16ltd4459.3PLA2G1B, PLA2G6
17indomethacin45 60 29 1112.3IFNG, LTF, PLA2G6, PLA2G1B
18actinomycin d459.3IFNG, SAT1, LTF, MMP9, PLA2G6
19cyclosporin a45 29 6011.1IFNG, LTF, MMP9, PLA2G6
20dexamethasone45 50 29 1111.9IFNG, LTF, MMP9, PLA2G6, PLA2G1B
21pge2458.7PLA2G1B, PLA2G6, MMP9, LTF, SAT1, IFNG

GO Terms for genes affiliated with Blepharitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.0LACRT, PLA2G1B, LTF
2extracellular regionGO:0055767.9CST4, LTF, MMP9, PLA2G1B, LACRT, LYZ

Biological processes related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G1B, PLA2G6
2defense response to bacteriumGO:0427429.3LYZ, LTF, IFNG
3endoplasmic reticulum unfolded protein responseGO:0309689.3MBTPS2, IFNG, WIPI1

Molecular functions related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blepharitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet