Aliases & Classifications for Blepharitis

Summaries for Blepharitis

Disease Ontology : 12 An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow.

MalaCards based summary : Blepharitis is related to ectropion and uveitis. An important gene associated with Blepharitis is PLA2G6 (Phospholipase A2 Group VI), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Protein processing in endoplasmic reticulum. The drugs Hyaluronic acid and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Wikipedia : 71 Blepharitis (/blɛfəˈraɪtᵻs/ BLEF-ər-EYE-tis) is a common eye condition characterized by... more...

Related Diseases for Blepharitis

Diseases related to Blepharitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 ectropion 29.6 IL4 MMP9
2 uveitis 29.3 CD79A LYZ
3 ulcerative blepharitis 12.0
4 squamous blepharitis 12.0
5 blepharoconjunctivitis 11.2
6 keratosis follicularis spinulosa decalvans, x-linked 10.9
7 ichthyosis, congenital, autosomal recessive 11 10.8
8 hordeolum externum 10.8
9 eyelid disease 10.8
10 meibomian cyst 10.8
11 autism x-linked 4 10.3 MBTPS2 SAT1
12 klebsiella infection 10.3 MBTPS2 SAT1
13 complex partial epilepsy 10.3 MBTPS2 SAT1
14 natural killer cell leukemia 10.2 CCL11 MMP9
15 toxic optic neuropathy 10.2 CD79A MMP9
16 retinal artery occlusion 10.2 CCL11 MMP9
17 elastosis perforans serpiginosa 10.2 CD79A MBTPS2
18 cellulitis 10.2 CD79A MMP9
19 viral meningitis 10.2 CD79A MMP9
20 diversion colitis 10.2 CD79A MMP9
21 conjunctivitis 10.2
22 urethral intrinsic sphincter deficiency 10.1 IL4 MMP9
23 psychotic disorder 10.1 CCL11 IL4
24 retinal vascular disease 10.1 CCL11 IL4
25 omsk hemorrhagic fever 10.1 CD79A MMP9
26 drug psychosis 10.1 CCL11 CD79A
27 epithelioid malignant peripheral nerve sheath tumor 10.1 LYZ MMP9
28 cerebral primitive neuroectodermal tumor 10.1 CCL11 IL4
29 diabetic angiopathy 10.1 CD79A IL4
30 trachea leiomyoma 10.1 CCL11 IL4
31 alkhurma hemorrhagic fever 10.1 CD79A IL4
32 cutaneous fibrous histiocytoma 10.1 CCL11 IL4
33 polyneuropathy due to drug 10.1 CD79A IL4
34 cutaneous ganglioneuroma 10.1 CD79A IL4
35 hypoparathyroidism, x-linked 10.1 CD79A IL4
36 clostridium difficile colitis 10.0 CD79A IL4
37 lymphocytic gastritis 10.0 CCL11 IL4
38 sparganosis 10.0 CD79A IL4
39 spastic diplegia 10.0 CCL11 CD79A SHE
40 osteodysplasty precocious of danks mayne and kozlowski 10.0 CD79A IL4
41 thelaziasis 10.0 CCL11 IL4 MMP9
42 lymphoblastic leukemia 10.0 CCL11 IL4 MMP9
43 visceral steatosis 10.0 CCL11 IL4 MMP9
44 herpes simplex 10.0
45 loeffler syndrome 10.0 CD79A LYZ
46 gonadal disease 10.0 CD79A IL4
47 anterior dislocation of lens 10.0 CCL11 IL4 SHE
48 mikulicz disease 10.0 CD79A IL4
49 lupus erythematosus 10.0
50 angiokeratoma 10.0 CD79A LYZ

Comorbidity relations with Blepharitis via Phenotypic Disease Network (PDN):


Acute Cystitis Conjunctivitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Parkinson Disease, Late-Onset Schizophreniform Disorder

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to Blepharitis

Symptoms & Phenotypes for Blepharitis

Drugs & Therapeutics for Blepharitis

Drugs for Blepharitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
3
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
4
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
5
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
6
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
7
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
9
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
10
Glycerol Approved, Experimental Phase 4 56-81-5 753
11
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 5496 36294
12
Loteprednol Approved Phase 4,Phase 3,Phase 2 82034-46-6, 129260-79-3 444025 9865442
13
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
14
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
15
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
16
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
17
Fusidic Acid Approved Phase 4 6990-06-3 3000226
18 Chloramphenicol succinate Experimental Phase 4
19 Adjuvants, Immunologic Phase 4
20 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2
21 Tetrahydrozoline Phase 4,Phase 3,Phase 1,Phase 2
22 Dermatologic Agents Phase 4
23 Ophthalmic Solutions Phase 4,Phase 3,Phase 1,Phase 2
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Viscosupplements Phase 4
27 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
28 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2
30 Protective Agents Phase 4
31 Keratolytic Agents Phase 4
32 Antimalarials Phase 4,Phase 2
33 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2
34 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
35 Antiparasitic Agents Phase 4,Phase 3,Phase 2
36 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
37 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
38 glucocorticoids Phase 4,Phase 3,Phase 2
39
protease inhibitors Phase 4,Phase 3,Phase 2
40 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
41 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
42 Hormone Antagonists Phase 4,Phase 3,Phase 2
43 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2
44 Hormones Phase 4,Phase 3,Phase 2
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
46 Anti-Allergic Agents Phase 4,Phase 3,Phase 2
47 Erythromycin Estolate Phase 4
48 Erythromycin Ethylsuccinate Phase 4
49 Erythromycin stearate Phase 4
50 Antiemetics Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 52)
id Name Status NCT ID Phase
1 Lipids of the Human Tear Film and Their Effect on Tear Stability Unknown status NCT00803452 Phase 4
2 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome Unknown status NCT00344721 Phase 4
3 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4
4 Comparative Study in the Efficacy of Topical Besifloxocin With Erythromycin for the Management of Acute Blepharitis Completed NCT01478256 Phase 4
5 Efficacy and Safety of Posiformin 2 % Eye Ointment in the Treatment of Blepharitis Completed NCT01357538 Phase 4
6 Safety and Efficacy Study of AzaSite® in Subjects With Blepharitis Completed NCT00629941 Phase 4
7 Safety and Efficacy Pilot Study of AzaSite® (Azithromycin) in Subjects With Blepharitis Completed NCT00629980 Phase 4
8 Safety and Efficacy Pilot Study of AzaSite (Azithromycin) in Subjects With Blepharitis Completed NCT00629590 Phase 4
9 Safety and Efficacy Pilot Study of AzaSite® for Four Weeks in Subjects With Blepharitis Completed NCT00656539 Phase 4
10 Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye Completed NCT00987727 Phase 4
11 Zylet vs TobraDex in Blepharokeratoconjunctivitis Completed NCT00447577 Phase 4
12 Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis Active, not recruiting NCT01456780 Phase 4
13 The Efficacy of Permethrin 5% Treatment for Demodex - Blepharitis in Comparison to Fucithalmic (Fusidic Acid 1%) and Synthomycine 5% Enrolling by invitation NCT03105505 Phase 4
14 A Study to Evaluate the Clinical Efficacy and Safety of Tobradex® ST Compared to Azasite® in the Treatment of Subjects With Moderate to Severe Chronic Blepharitis Completed NCT01102244 Phase 3
15 Efficacy and Safety Study of a Steroid/Antibiotic Combination Eyedrop to Treat Non-Bacterial Blepharitis Completed NCT01408082 Phase 3
16 Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1% Completed NCT02236403 Phase 3
17 Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis Completed NCT00732446 Phase 3
18 Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes Completed NCT00796926 Phase 3
19 Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis Completed NCT01028027 Phase 3
20 Comparative Study to Evaluate ISV-305 Compared to Vehicle in Blepharitis Subjects Not yet recruiting NCT01543490 Phase 3
21 Antibiotic Steroid Combination Compared With Individual Administration in the in the Treatment of Ocular Inflammation and Infection Withdrawn NCT01721694 Phase 3
22 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2
23 Oral Azithromycin Versus Doxycycline in Posterior Blepharitis Completed NCT01783860 Phase 2
24 Tea Tree Oil in the Treatment of Chronic Blepharitis Completed NCT01073150 Phase 2
25 Efficacy and Safety Assessment of Azyter® Eye Drops (T1225) in Patients With Blepharitis Completed NCT01089608 Phase 2
26 Topical IL-1-Ra for Treatment of Posterior Blepharitis Completed NCT00681109 Phase 1, Phase 2
27 Treatment of Patients With Blepharitis and Facial Rosacea Completed NCT00560703 Phase 2
28 The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period Completed NCT00892970 Phase 2
29 The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638) Completed NCT00894530 Phase 2
30 Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease Completed NCT02218489 Phase 2
31 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2
32 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Vehicle in Subjects With Blepharitis (P08636) Terminated NCT01269658 Phase 2
33 A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641) Terminated NCT01220258 Phase 2
34 A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates Terminated NCT00579020 Phase 2
35 Demodex Blepharitis Treatment Study Unknown status NCT01647217 Phase 1
36 Efficacy of iLid Cleanser (Avenova) Versus Vehicle on Ocular Skin Flora Unknown status NCT02455895
37 Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma Unknown status NCT01284439
38 Blephacura Versus Baby Shampoo to Treat Blepharitis Completed NCT01115192
39 Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery Completed NCT01808560
40 Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points Completed NCT00345241
41 Investigation of Chronic Inflammatory Processes in Male Individuals With Hypohidrotic Ectodermal Dysplasia Completed NCT01308333
42 Evaluation and Treatment of Patients With Corneal and External Diseases Completed NCT00008541
43 Changes of Inflammatory Cytokines in the Tears of Moderate and Severe MGD Treated With Topical Loteprednol Etabonate Completed NCT01692652
44 Effects of Minocycline on Cytokine Levels in Severe Meibomian Gland Dysfunction Completed NCT01600625
45 Comparison of BlephEx to MiBoflo as Treatment Options for Blepharitis Recruiting NCT02952079
46 Ocular Comfort and Inflammation in Lid Hygiene Therapy Recruiting NCT02938078
47 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa Recruiting NCT02386774
48 Effect of Meibomian Gland Probing on Ocular Surface in Ocular Rosacea Recruiting NCT02735681
49 mDixon TSE MRI Sequence And Conventional MRI Sequences In Dysimmune Orbitopathies (DDX) Recruiting NCT02397109
50 The Effect of Meibomian Glands Massage on Signs and Symptoms of Dry Eye Enrolling by invitation NCT03104894

Search NIH Clinical Center for Blepharitis

Cochrane evidence based reviews: blepharitis

Genetic Tests for Blepharitis

Genetic tests related to Blepharitis:

id Genetic test Affiliating Genes
1 Blepharitis 29

Anatomical Context for Blepharitis

MalaCards organs/tissues related to Blepharitis:

39
Eye, Testes, Skin

Publications for Blepharitis

Articles related to Blepharitis:

(show top 50) (show all 249)
id Title Authors Year
1
Comparison of therapeutic effects of topical azithromycin solution and systemic doxycycline on posterior blepharitis. ( 27500111 )
2016
2
Recurrent Fungal Keratitis and Blepharitis Caused by Aspergillus flavus. ( 27621301 )
2016
3
The Effect of Demodex Infestation on Blepharitis and the Ocular Symptoms. ( 26783981 )
2016
4
Demodex folliculorum: Following the trail to chronic blepharitis. ( 26775083 )
2016
5
Loteprednol Etabonate 0.5%/Tobramycin 0.3% Compared with Dexamethasone 0.1%/Tobramycin 0.3% for the Treatment of Blepharitis. ( 26788833 )
2016
6
A randomized, double-masked, parallel-group, comparative study to evaluate the clinical efficacy and safety of 1% azithromycin-0.1% dexamethasone combination compared to 1% azithromycin alone, 0.1% dexamethasone alone, and vehicle in the treatment of subjects with blepharitis. ( 27570444 )
2016
7
Treatment With Doxycycline for Severe Bortezomib-Associated Blepharitis. ( 27349766 )
2016
8
DEBS - a unification theory for dry eye and blepharitis. ( 28003734 )
2016
9
Oral azithromycin and blepharitis: symptoms and signs improve, so where are the publications? ( 27356302 )
2016
10
Meibomian gland dysfunction: azithromycin and objective improvement in outcomes in posterior blepharitis. ( 27314917 )
2016
11
Efficacy and Safety of Topical Atorvastatin for the Treatment of Dry Eye Associated with Blepharitis: A Pilot Study. ( 26068735 )
2015
12
WITHDRAWN: Azithromycin 1.5% Ophthalmic Solution for Blepharitis Treatment: Comparison of 14- Versus 30-Day Treatment. ( 26717146 )
2015
13
Medical management of blepharitis. ( 26058027 )
2015
14
Acute blepharitis: an unusual complication of zoledronic acid. ( 26412501 )
2015
15
Treatment Options for Demodex Blepharitis: Patient Choice and Efficacy. ( 25902082 )
2015
16
Common Blepharitis Related to Phthiriasis Palpebrarum: Argon Laser Phototherapy. ( 26470938 )
2015
17
Comparative study of the efficacy of different treatment options in patients with chronic blepharitis. ( 25542616 )
2015
18
Blepharitis: remains a diagnostic enigma. A role for tea tree oil shampoo? ( 26293141 )
2015
19
Cheek and periorbital peculiar discoid lupus erythematosus: rare clinical presentation mimicking tinea faciei, cutaneous granulomatous disease or blepharitis. ( 25969679 )
2015
20
Utilisation of a Novel Test to Measure Severity and Treatment Efficacy of Posterior Blepharitis. ( 26347811 )
2015
21
Periodic acid-Schiff staining demonstrates fungi in chronic anterior blepharitis. ( 26293142 )
2015
22
Blepharitis: always remember demodex. ( 25371637 )
2014
23
Treatment of blepharitis: recent clinical trials. ( 25284773 )
2014
24
Intraductal meibomian gland probing for the treatment of blepharitis. ( 25001110 )
2014
25
Staphylococcus aureus Blepharitis Associated with Multiple Corneal Stromal Microabscess, Stromal Edema, and Uveitis. ( 24410378 )
2014
26
STAT6-mediated keratitis and blepharitis: a novel murine model of ocular atopic dermatitis. ( 24845637 )
2014
27
Herpes simplex virus blepharitis in a patient with Crohn's colitis. ( 24613714 )
2014
28
Two cases of tinea ciliaris with blepharitis due to Microsporum audouinii and Trichophyton verrucosum and review of the literature. ( 24724801 )
2014
29
Ocular rosacea: an underdiagnosed cause of relapsing conjunctivitis-blepharitis in the elderly. ( 25239991 )
2014
30
Malassezia spp on the periocular skin of dogs and their association with blepharitis, ocular discharge, and the application of ophthalmic medications. ( 24846431 )
2014
31
A novel gammaherpesvirus in a large flying fox (Pteropus vampyrus) with blepharitis. ( 23628640 )
2013
32
Chronic blepharitis. ( 23799315 )
2013
33
Assessment of signs of anterior blepharitis using standardized color photographs. ( 24055901 )
2013
34
Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease. ( 23220580 )
2013
35
Assessment of the tolerability profile of an ophthalmic solution of 5% glycyrrhizin and copolymer PEG/PPG on healthy volunteers and evaluation of its efficacy in the treatment of moderate to severe blepharitis. ( 23874081 )
2013
36
More than scratching the surface: a shift of focus in blepharitis management. ( 23902351 )
2013
37
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. ( 23565576 )
2013
38
Patients with blepharitis are at elevated risk of anxiety and depression. ( 24386181 )
2013
39
Ethyl ether: an old ally against oral ivermectin resistant demodex blepharitis. ( 24269425 )
2013
40
Severe chronic blepharitis and scarring ectropion associated with discoid lupus erythematosus. ( 22845188 )
2013
41
Successful treatment of blepharitis with bibrocathol (PosiforminAr 2 %). ( 22527308 )
2012
42
Demodex blepharitis. ( 22214946 )
2012
43
Safety and efficacy of moxifloxacin-dexamethasone eyedrops as treatment for bacterial ocular infection associated with bacterial blepharitis. ( 22562783 )
2012
44
Blepharitis. ( 22623633 )
2012
45
Symptomatic relief associated with eyelid hygiene in anterior blepharitis and MGD. ( 22890228 )
2012
46
Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis. ( 23255861 )
2012
47
Eyelid margin modification associated with eyelid hygiene in anterior blepharitis and meibomian gland dysfunction. ( 22890229 )
2012
48
Association of blepharitis with Demodex: a meta-analysis. ( 22364595 )
2012
49
Role of Demodex folliculorum in the pathogenesis of blepharitis. ( 22429751 )
2012
50
Comparative ocular microbial communities in humans with and without blepharitis. ( 22836761 )
2012

Variations for Blepharitis

Expression for Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for Blepharitis

GO Terms for Blepharitis

Biological processes related to Blepharitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell activation GO:0042113 9.26 CD79A IL4
2 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.16 MMP9 PLA2G6
3 chemotaxis GO:0006935 9.13 CCL11 IL4 PLA2G6
4 positive regulation of protein phosphorylation GO:0001934 8.8 IL4 MMP9 PLA2G6

Sources for Blepharitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....