MCID: BLP005
MIFTS: 40

Blepharitis malady

Eye diseases, Skin diseases categories

Summaries for Blepharitis

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Disease Ontology:9 An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow.

MalaCards based summary: Blepharitis, also known as infective dermatitis of eyelid of types resulting in deformity, is related to conjunctivitis and ulcerative blepharitis. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways are Spinal Cord Injury and Immune response Role of DAP12 receptors in NK cells. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Wikipedia:63 Blepharitis (/bl?f?r?a?t?s/ BLEF-?r-EYE-tis) is a common eye condition characterized by often chronic... more...

Aliases & Classifications for Blepharitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Blepharitis, Aliases & Descriptions:

Name: Blepharitis 9 11 43 60
Infective Dermatitis of Eyelid of Types Resulting in Deformity 9
 
Infective Eyelid Dermatitis of Types Resulting in Deformity 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Skin diseases


Related Diseases for Blepharitis

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Diseases related to Blepharitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.5
2ulcerative blepharitis10.4
3herpes simplex10.3
4keratosis follicularis spinulosa decalvans, x-linked10.2
5squamous blepharitis10.2
6blepharoconjunctivitis10.2
7lupus erythematosus10.2
8rosacea10.2
9discoid lupus erythematosus10.2
10odontoonychodermal dysplasia10.1
11dermatitis10.1
12leukonychia totalis10.1
13pleurisy10.1PLA2G6
14periodontitis10.1MMP9
15moebius syndrome10.0
16sea-blue histiocyte disease10.0
17coffin-lowry syndrome10.0
18keratitis10.0
19acne10.0
20cornelia de lange syndrome10.0
2117q23.1q23.2 microdeletion syndrome10.0
22severe generalized recessive dystrophic epidermolysis bullosa10.0
23blindness10.0
24epidermolysis bullosa simplex due to plakophilin deficiency10.0
25tropical spastic paraparesis10.0IFNG, MMP9
26relapsing-remitting multiple sclerosis9.9MMP9, IFNG
27systemic lupus erythematosus9.9
28muckle-wells syndrome9.9
29cinca syndrome9.9
30inflammatory skin and bowel disease, neonatal, 19.9
31ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive9.9
32ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 39.9
33crouzon syndrome with acanthosis nigricans9.9
34trichomegaly9.9
35wegener granulomatosis9.9
36xeroderma pigmentosum, variant type9.9
37candidiasis, familial, 89.9
38melkersson-rosenthal syndrome9.9
39crouzon syndrome9.9
40ichthyosis, congenital, autosomal recessive 119.9
41poikiloderma with neutropenia9.9
42tyrosinemia, type ii9.9
43riboflavin deficiency9.9
44sjogren-larsson syndrome9.9
45majeed syndrome9.9
46kawasaki disease9.9
47kindler syndrome9.9
48holocarboxylase synthetase deficiency9.9
49wiskott-aldrich syndrome9.9
50dyskeratosis congenita, x-linked9.9

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Symptoms for Blepharitis

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Drugs & Therapeutics for Blepharitis

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Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Genetic Tests for Blepharitis

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Anatomical Context for Blepharitis

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MalaCards organs/tissues related to Blepharitis:

31
Eye, Skin, Testes

Animal Models for Blepharitis or affiliated genes

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Publications for Blepharitis

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Articles related to Blepharitis:

(show top 50)    (show all 228)
idTitleAuthorsYear
1
Treatment Options for Demodex Blepharitis: Patient Choice and Efficacy. (25902082)
2015
2
Treatment of blepharitis: recent clinical trials. (25284773)
2014
3
Blepharitis: always remember demodex. (25371637)
2014
4
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. (23565576)
2013
5
Ethyl ether: an old ally against oral ivermectin resistant demodex blepharitis. (24269425)
2013
6
Comparative ocular microbial communities in humans with and without blepharitis. (22836761)
2012
7
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. (22872200)
2012
8
Oral azithromycin for treatment of posterior blepharitis. (21849891)
2011
9
Tear cytokines and chemokines in patients with Demodex blepharitis. (21050771)
2011
10
Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. (20508503)
2010
11
Pathogenic role of Demodex mites in blepharitis. (20689407)
2010
12
Diagnosis and treatment of demodectic blepharitis. (19367544)
2009
13
Phthriasis palpebrarum mimicking lid eczema and blepharitis. (20339456)
2009
14
Treatment of Malassezia species associated seborrheic blepharitis with fluconazole. (19957565)
2009
15
Chronic blepharitis caused by Demodex folliculorum mites. (19291177)
2009
16
Contact lenses and associated anterior segment disorders: dry eye disease, blepharitis, and allergy. (18282548)
2008
17
Reversible tetracycline staining of adult dentition in the treatment of chronic blepharitis. (17704757)
2007
18
Blepharitis, allergy, and dry eye: lumpers and splitters. (17209246)
2006
19
Discoid lupus erythematosus of the eyelids associated with staphylococcal blepharitis and Meibomian gland dysfunction. (16309490)
2006
20
Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. (15952718)
2005
21
Sodium bicarbonate in the treatment of blepharitis. (16033379)
2005
22
My husband was recently diagnosed with blepharitis. Could you explain what this eye disorder is? (15101344)
2004
23
Contact lenses and associated anterior segment disorders: dry eye, blepharitis, and allergy. (14564767)
2003
24
Quantitative evaluation of atopic blepharitis by scoring of eyelid conditions and measuring the water content of the skin and evaporation from the eyelid surface. (11322412)
2001
25
Ophthaproblem. Blepharitis. (11153404)
2000
26
Slime production by coagulase-negative staphylococci isolated in chronic blepharitis. (9590586)
1998
27
Blepharitis. (9604424)
1998
28
Experiences in treating patients for blepharitis. (9715707)
1998
29
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
30
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. (8694093)
1996
31
Meibomian gland triglyceride fatty acid differences in chronic blepharitis patients. (8776558)
1996
32
Unilateral Malassezia furfur blepharitis after perforating keratoplasty. (8695578)
1996
33
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
34
Clinical diagnosis of recurrent herpes simplex blepharitis in an adult: a case report. (8014364)
1994
35
Chronic blepharitis: easy nursing interventions for a common problem. (1542124)
1992
36
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
37
Unilateral chronic granulomatous blepharitis as a leading symptom of Oriental cutaneous leishmaniasis in Germany. Giesma stain as rapid diagnosis and initial description of systemic therapy with gamma-interferon]. (1578880)
1992
38
Management of chronic blepharitis. (2546524)
1989
39
Blepharitis. Can the dermatologist help? (2737816)
1989
40
Treatment of chronic blepharitis. (3369983)
1988
41
Blepharitis associated with acne rosacea and seborrheic dermatitis. (3156100)
1985
42
Tear lysozyme measurements in chronic blepharitis. (3977218)
1985
43
Classification of chronic blepharitis. (6218459)
1982
44
Staphylococcal blepharitis. (324453)
1977
45
The masked rat. An X-ray induced mutant with chronic blepharitis, alopecia, and pasteurellosis. (1262697)
1976
46
Selsunef ointment to treat squamous blepharitis. (14414681)
1960
47
Selenium (selsun) in the treatment of marginal blepharitis. (13282550)
1956
48
The etiology and treatment of blepharitis; a study in military personnel. (21019819)
1946
49
Etiology and treatment of blepharitis; a study in military personnel. (21002032)
1946
50
Acute Blepharitis, due to the Primula Obconica. (19990000)
1934

Variations for Blepharitis

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Expression for genes affiliated with Blepharitis

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Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

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Pathways related to Blepharitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PLA2G6, IFNG, MMP9
2
Show member pathways
Immune response CD16 signaling in NK cells58
9.2PLA2G1B, PLA2G6, IFNG

Compounds for genes affiliated with Blepharitis

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Compounds related to Blepharitis according to GeneCards Suite gene sharing:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tranilast4310.0MMP9, IFNG
2scalaradial439.9PLA2G6, PLA2G1B
3manoalide439.9PLA2G6, PLA2G1B
4p-bromophenacyl bromide439.9PLA2G6, PLA2G1B
5minocycline43 1210.8LTF, MMP9
6melittin439.8PLA2G6, PLA2G1B
7succinate439.8LTF, PLA2G6, MMP9
8ribavirin43 49 1211.8LTF, IFNG, MMP9
9aacocf3439.8PLA2G6, PLA2G1B
10lysophospholipid439.7PLA2G6, PLA2G1B
11hydrocortisone43 2 59 1212.7LTF, PLA2G6, IFNG
12aristolochic acid43 210.6PLA2G6, PLA2G1B
13leukotriene b443 59 2411.6LTF, PLA2G1B, MMP9
14simvastatin43 49 59 28 24 1214.6IFNG, MMP9, LIPA
15ltd4439.6PLA2G1B, PLA2G6
16endotoxin439.4LTF, PLA2G1B, IFNG
17actinomycin d439.4LTF, PLA2G6, IFNG, MMP9
18adenylate439.4LTF, PLA2G6, MMP9, LIPA
19cyclosporin a43 28 5911.4MMP9, IFNG, PLA2G6, LTF
20prostaglandin439.3PLA2G1B, PLA2G6, MMP9
21LysoPC(O-18:0)249.3PLA2G1B, PLA2G6
22indomethacin43 28 59 1212.3IFNG, PLA2G6, PLA2G1B, LTF
23phosphatidylcholine439.2PLA2G6, PLA2G1B, LTF
24cysteine439.0LIPA, MMP9, IFNG, PLA2G6, LTF
25pge2438.9LTF, PLA2G1B, PLA2G6, IFNG, MMP9
26dexamethasone43 49 28 1211.9MMP9, IFNG, PLA2G6, PLA2G1B, LTF

GO Terms for genes affiliated with Blepharitis

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Cellular components related to Blepharitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301418.9PLA2G1B, LTF, LACRT
2extracellular regionGO:00055768.5LACRT, MMP9, IFNG, PLA2G1B, LTF
3extracellular spaceGO:00056157.8PLA2G1B, LACRT, MMP9, LTF, CST4, IFNG

Biological processes related to Blepharitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine acyl-chain remodelingGO:00361519.6PLA2G1B, PLA2G6
2phosphatidylethanolamine acyl-chain remodelingGO:00361529.3PLA2G1B, PLA2G6

Molecular functions related to Blepharitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:00046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Blepharitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet