MCID: BLP005
MIFTS: 43

Blepharitis malady

Eye diseases category

Summaries for Blepharitis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Blepharitis (/bl?f?r?a?t?s/ BLEF-?r-EYE-tis) is an eye condition characterized by chronic inflammation... more...

MalaCards: Blepharitis is related to conjunctivitis and ulcerative blepharitis. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways are Spinal Cord Injury and Immune response Role of DAP12 receptors in NK cells. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Aliases & Classifications for Blepharitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

blepharitis 9 11 46 63


Related Diseases for Blepharitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Blepharitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.5
2ulcerative blepharitis10.3
3herpes simplex10.3
4lupus erythematosus10.2
5rosacea10.2
6squamous blepharitis10.2
7discoid lupus erythematosus10.2
8blepharoconjunctivitis10.1
9keratosis follicularis spinulosa decalvans, x-linked10.1
10pleurisy10.0PLA2G6
11acne10.0
12dermatitis10.0
13leukonychia totalis10.0
14odontoonychodermal dysplasia10.0
15epidermolysis bullosa dystrophica, ar10.0
16xeroderma pigmentosum, group a10.0
17agammaglobulinemia, x-linked 110.0
18blindness10.0
19periodontitis10.0MMP9
20tropical spastic paraparesis10.0IFNG, MMP9
21relapsing-remitting multiple sclerosis10.0IFNG, MMP9
22septic shock10.0PLA2G6, LTF, PLA2G1B
23pancreatitis10.0PLA2G1B, LTF, PLA2G6
24ulcerative colitis9.9IFNG, LTF, PLA2G6
25melkersson-rosenthal syndrome9.9
26relapsing polychondritis9.9
27nodular nonsuppurative panniculitis9.9
28muckle-wells syndrome9.9
29lassa fever9.9
30takayasu's arteritis9.9
31giant papillary conjunctivitis9.9
32crouzon syndrome9.9
33polyarteritis nodosa9.9
34lyme disease9.9
35acquired immunodeficiency syndrome9.9
36reactive arthritis9.9
37whipple disease9.9
38ariboflavinosis9.9
39biotinidase deficiency9.9
40holocarboxylase synthetase deficiency9.9
41phlyctenulosis9.9
42hallermann-streiff syndrome9.9
43junctional epidermolysis bullosa9.9
44ladd syndrome9.9
45juvenile xanthogranuloma9.9
46sea-blue histiocyte syndrome9.9
47folliculitis9.9
48aniridia9.9
49crimean-congo hemorrhagic fever9.9
50cutaneous leishmaniasis9.9

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Symptoms for Blepharitis

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Drugs & Therapeutics for Blepharitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Blepharitis

Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Search CenterWatch for Blepharitis

Genetic Tests for Blepharitis

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Anatomical Context for Blepharitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Blepharitis:

34
Eye, Skin, Testes

Animal Models for Blepharitis or affiliated genes

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Publications for Blepharitis

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Sources:
53PubMed
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Articles related to Blepharitis:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. (23565576)
2013
2
Ethyl ether: an old ally against oral ivermectin resistant demodex blepharitis. (24269425)
2013
3
Comparative ocular microbial communities in humans with and without blepharitis. (22836761)
2012
4
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. (22872200)
2012
5
Oral azithromycin for treatment of posterior blepharitis. (21849891)
2011
6
Tear cytokines and chemokines in patients with Demodex blepharitis. (21050771)
2011
7
Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. (20508503)
2010
8
Pathogenic role of Demodex mites in blepharitis. (20689407)
2010
9
Diagnosis and treatment of demodectic blepharitis. (19367544)
2009
10
Phthriasis palpebrarum mimicking lid eczema and blepharitis. (20339456)
2009
11
Treatment of Malassezia species associated seborrheic blepharitis with fluconazole. (19957565)
2009
12
Chronic blepharitis caused by Demodex folliculorum mites. (19291177)
2009
13
Contact lenses and associated anterior segment disorders: dry eye disease, blepharitis, and allergy. (18282548)
2008
14
Reversible tetracycline staining of adult dentition in the treatment of chronic blepharitis. (17704757)
2007
15
Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis with cylindrical dandruff. (17592319)
2007
16
Blepharitis, allergy, and dry eye: lumpers and splitters. (17209246)
2006
17
Discoid lupus erythematosus of the eyelids associated with staphylococcal blepharitis and Meibomian gland dysfunction. (16309490)
2006
18
Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. (15952718)
2005
19
Sodium bicarbonate in the treatment of blepharitis. (16033379)
2005
20
My husband was recently diagnosed with blepharitis. Could you explain what this eye disorder is? (15101344)
2004
21
Contact lenses and associated anterior segment disorders: dry eye, blepharitis, and allergy. (14564767)
2003
22
Quantitative evaluation of atopic blepharitis by scoring of eyelid conditions and measuring the water content of the skin and evaporation from the eyelid surface. (11322412)
2001
23
Ophthaproblem. Blepharitis. (11153404)
2000
24
Slime production by coagulase-negative staphylococci isolated in chronic blepharitis. (9590586)
1998
25
Blepharitis. (9604424)
1998
26
Experiences in treating patients for blepharitis. (9715707)
1998
27
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
28
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. (8694093)
1996
29
Meibomian gland triglyceride fatty acid differences in chronic blepharitis patients. (8776558)
1996
30
Unilateral Malassezia furfur blepharitis after perforating keratoplasty. (8695578)
1996
31
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
32
Clinical diagnosis of recurrent herpes simplex blepharitis in an adult: a case report. (8014364)
1994
33
Chronic blepharitis: easy nursing interventions for a common problem. (1542124)
1992
34
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
35
Unilateral chronic granulomatous blepharitis as a leading symptom of Oriental cutaneous leishmaniasis in Germany. Giesma stain as rapid diagnosis and initial description of systemic therapy with gamma-interferon]. (1578880)
1992
36
Tear cholesterol levels in blepharitis. (2090980)
1990
37
Management of chronic blepharitis. (2546524)
1989
38
Blepharitis. Can the dermatologist help? (2737816)
1989
39
Treatment of chronic blepharitis. (3369983)
1988
40
Blepharitis associated with acne rosacea and seborrheic dermatitis. (3156100)
1985
41
Tear lysozyme measurements in chronic blepharitis. (3977218)
1985
42
Classification of chronic blepharitis. (6218459)
1982
43
Staphylococcal blepharitis. (324453)
1977
44
The masked rat. An X-ray induced mutant with chronic blepharitis, alopecia, and pasteurellosis. (1262697)
1976
45
Demodex: a cause of blepharitis in Australia. (5797166)
1969
46
Selsunef ointment to treat squamous blepharitis. (14414681)
1960
47
Selenium (selsun) in the treatment of marginal blepharitis. (13282550)
1956
48
The etiology and treatment of blepharitis; a study in military personnel. (21019819)
1946
49
Etiology and treatment of blepharitis; a study in military personnel. (21002032)
1946
50
Acute Blepharitis, due to the Primula Obconica. (19990000)
1934

Variations for Blepharitis

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Expression for genes affiliated with Blepharitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Blepharitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PLA2G6, IFNG, MMP9
2
Show member pathways
Immune response CD16 signaling in NK cells61
9.2PLA2G1B, PLA2G6, IFNG

Compounds for genes affiliated with Blepharitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Blepharitis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tranilast4610.0IFNG, MMP9
2scalaradial469.9PLA2G6, PLA2G1B
3manoalide469.9PLA2G6, PLA2G1B
4p-bromophenacyl bromide469.9PLA2G1B, PLA2G6
5minocycline46 1210.8LTF, MMP9
6melittin469.8PLA2G6, PLA2G1B
7succinate469.8MMP9, LTF, PLA2G6
8ribavirin46 52 1211.8IFNG, LTF, MMP9
9aacocf3469.8PLA2G1B, PLA2G6
10lysophospholipid469.7PLA2G1B, PLA2G6
11hydrocortisone46 3 62 1212.7IFNG, LTF, PLA2G6
12aristolochic acid46 310.6PLA2G6, PLA2G1B
13leukotriene b446 62 2511.6LTF, MMP9, PLA2G1B
14simvastatin46 52 62 30 25 1214.6MMP9, IFNG, LIPA
15ltd4469.6PLA2G1B, PLA2G6
16endotoxin469.4LTF, IFNG, PLA2G1B
17actinomycin d469.4IFNG, PLA2G6, LTF, MMP9
18adenylate469.4MMP9, PLA2G6, LIPA, LTF
19cyclosporin a46 30 6211.4PLA2G6, IFNG, LTF, MMP9
20prostaglandin469.3PLA2G6, MMP9, PLA2G1B
21LysoPC(O-18:0)259.3PLA2G1B, PLA2G6
22indomethacin46 30 62 1212.3IFNG, PLA2G1B, LTF, PLA2G6
23phosphatidylcholine469.2PLA2G6, PLA2G1B, LTF
24cysteine469.0LIPA, MMP9, IFNG, PLA2G6, LTF
25pge2468.9IFNG, PLA2G1B, PLA2G6, MMP9, LTF
26dexamethasone46 52 30 1211.9MMP9, PLA2G1B, IFNG, PLA2G6, LTF

GO Terms for genes affiliated with Blepharitis

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Sources:
17Gene Ontology
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Cellular components related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.9PLA2G1B, LTF, LACRT
2extracellular regionGO:0055768.5LACRT, MMP9, IFNG, PLA2G1B, LTF
3extracellular spaceGO:0056157.8PLA2G1B, LACRT, MMP9, LTF, CST4, IFNG

Biological processes related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine acyl-chain remodelingGO:0361519.6PLA2G1B, PLA2G6
2phosphatidylethanolamine acyl-chain remodelingGO:0361529.3PLA2G1B, PLA2G6

Molecular functions related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blepharitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet