MCID: BLP005
MIFTS: 43

Blepharitis malady

Eye diseases category
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Summaries for Blepharitis

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Wikipedia:65 Blepharitis (/bl?f?r?a?t?s/ BLEF-?r-EYE-tis) is an eye condition characterized by chronic inflammation... more...

MalaCards based summary: Blepharitis is related to conjunctivitis and ulcerative blepharitis. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways are Spinal Cord Injury and Immune response Role of DAP12 receptors in NK cells. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Aliases & Classifications for Blepharitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Blepharitis, Aliases & Descriptions:

Name: Blepharitis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Related Diseases for Blepharitis

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Diseases related to Blepharitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.5
2ulcerative blepharitis10.3
3herpes simplex10.3
4rosacea10.2
5lupus erythematosus10.2
6squamous blepharitis10.2
7discoid lupus erythematosus10.2
8blepharoconjunctivitis10.1
9dermatitis10.1
10keratosis follicularis spinulosa decalvans, x-linked10.1
11pleurisy10.1PLA2G6
12periodontitis10.1MMP9
13acne10.0
14keratitis10.0
15leukonychia totalis10.0
16odontoonychodermal dysplasia10.0
17epidermolysis bullosa dystrophica, ar10.0
18xeroderma pigmentosum, group a10.0
19agammaglobulinemia, x-linked 110.0
20blindness10.0
21tropical spastic paraparesis10.0IFNG, MMP9
22relapsing-remitting multiple sclerosis9.9MMP9, IFNG
23alopecia9.9
24cataract9.9
25crouzon syndrome9.9
26cutaneous leishmaniasis9.9
27malt lymphoma9.9
28neutropenia9.9
29sjogren-larsson syndrome9.9
30systemic lupus erythematosus9.9
31wiskott-aldrich syndrome9.9
32relapsing polychondritis9.9
33takayasu's arteritis9.9
34giant papillary conjunctivitis9.9
35melkersson-rosenthal syndrome9.9
36nodular nonsuppurative panniculitis9.9
37acquired immunodeficiency syndrome9.9
38reactive arthritis9.9
39holocarboxylase synthetase deficiency9.9
40biotinidase deficiency9.9
41scrub typhus9.9
42kawasaki disease9.9
43muckle-wells syndrome9.9
44lassa fever9.9
45polyarteritis nodosa9.9
46lyme disease9.9
47hallermann-streiff syndrome9.9
48ladd syndrome9.9
49sea-blue histiocyte syndrome9.9
50juvenile xanthogranuloma9.9

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Symptoms for Blepharitis

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Drugs & Therapeutics for Blepharitis

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Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Genetic Tests for Blepharitis

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Anatomical Context for Blepharitis

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MalaCards organs/tissues related to Blepharitis:

32
Eye, Skin, Testes

Animal Models for Blepharitis or affiliated genes

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Publications for Blepharitis

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Articles related to Blepharitis:

(show top 50)    (show all 225)
idTitleAuthorsYear
1
Treatment of blepharitis: recent clinical trials. (25284773)
2014
2
Blepharitis: always remember demodex. (25371637)
2014
3
Demodex blepharitis mimicking eyelid sebaceous gland carcinoma. (23565576)
2013
4
Ethyl ether: an old ally against oral ivermectin resistant demodex blepharitis. (24269425)
2013
5
Comparative ocular microbial communities in humans with and without blepharitis. (22836761)
2012
6
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. (22872200)
2012
7
Oral azithromycin for treatment of posterior blepharitis. (21849891)
2011
8
Tear cytokines and chemokines in patients with Demodex blepharitis. (21050771)
2011
9
Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. (20508503)
2010
10
Pathogenic role of Demodex mites in blepharitis. (20689407)
2010
11
Diagnosis and treatment of demodectic blepharitis. (19367544)
2009
12
Phthriasis palpebrarum mimicking lid eczema and blepharitis. (20339456)
2009
13
Treatment of Malassezia species associated seborrheic blepharitis with fluconazole. (19957565)
2009
14
Contact lenses and associated anterior segment disorders: dry eye disease, blepharitis, and allergy. (18282548)
2008
15
Reversible tetracycline staining of adult dentition in the treatment of chronic blepharitis. (17704757)
2007
16
Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis with cylindrical dandruff. (17592319)
2007
17
Blepharitis, allergy, and dry eye: lumpers and splitters. (17209246)
2006
18
Discoid lupus erythematosus of the eyelids associated with staphylococcal blepharitis and Meibomian gland dysfunction. (16309490)
2006
19
Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. (15952718)
2005
20
Sodium bicarbonate in the treatment of blepharitis. (16033379)
2005
21
My husband was recently diagnosed with blepharitis. Could you explain what this eye disorder is? (15101344)
2004
22
Contact lenses and associated anterior segment disorders: dry eye, blepharitis, and allergy. (14564767)
2003
23
Quantitative evaluation of atopic blepharitis by scoring of eyelid conditions and measuring the water content of the skin and evaporation from the eyelid surface. (11322412)
2001
24
Ophthaproblem. Blepharitis. (11153404)
2000
25
Slime production by coagulase-negative staphylococci isolated in chronic blepharitis. (9590586)
1998
26
Experiences in treating patients for blepharitis. (9715707)
1998
27
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
28
The effect of Staphylococcus aureus phage lysate vaccine on a rabbit model of staphylococcal blepharitis, phlyctenulosis, and catarrhal infiltrates. (8694093)
1996
29
Meibomian gland triglyceride fatty acid differences in chronic blepharitis patients. (8776558)
1996
30
Unilateral Malassezia furfur blepharitis after perforating keratoplasty. (8695578)
1996
31
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
32
Clinical diagnosis of recurrent herpes simplex blepharitis in an adult: a case report. (8014364)
1994
33
Chronic blepharitis: easy nursing interventions for a common problem. (1542124)
1992
34
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
35
Unilateral chronic granulomatous blepharitis as a leading symptom of Oriental cutaneous leishmaniasis in Germany. Giesma stain as rapid diagnosis and initial description of systemic therapy with gamma-interferon]. (1578880)
1992
36
Tear cholesterol levels in blepharitis. (2090980)
1990
37
Management of chronic blepharitis. (2546524)
1989
38
Blepharitis. Can the dermatologist help? (2737816)
1989
39
Treatment of chronic blepharitis. (3369983)
1988
40
Blepharitis associated with acne rosacea and seborrheic dermatitis. (3156100)
1985
41
Tear lysozyme measurements in chronic blepharitis. (3977218)
1985
42
Classification of chronic blepharitis. (6218459)
1982
43
Staphylococcal blepharitis. (324453)
1977
44
The masked rat. An X-ray induced mutant with chronic blepharitis, alopecia, and pasteurellosis. (1262697)
1976
45
Demodex: a cause of blepharitis in Australia. (5797166)
1969
46
Selsunef ointment to treat squamous blepharitis. (14414681)
1960
47
Selenium (selsun) in the treatment of marginal blepharitis. (13282550)
1956
48
The etiology and treatment of blepharitis; a study in military personnel. (21019819)
1946
49
Etiology and treatment of blepharitis; a study in military personnel. (21002032)
1946
50
Acute Blepharitis, due to the Primula Obconica. (19990000)
1934

Variations for Blepharitis

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Expression for genes affiliated with Blepharitis

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Expression patterns in normal tissues for genes affiliated with Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

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Pathways related to Blepharitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3PLA2G6, IFNG, MMP9
2
Show member pathways
Immune response CD16 signaling in NK cells60
9.2PLA2G1B, PLA2G6, IFNG

Compounds for genes affiliated with Blepharitis

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Compounds related to Blepharitis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tranilast4410.0MMP9, IFNG
2scalaradial449.9PLA2G6, PLA2G1B
3manoalide449.9PLA2G6, PLA2G1B
4p-bromophenacyl bromide449.9PLA2G6, PLA2G1B
5minocycline44 1110.8LTF, MMP9
6melittin449.8PLA2G6, PLA2G1B
7succinate449.8LTF, PLA2G6, MMP9
8ribavirin44 50 1111.8LTF, IFNG, MMP9
9aacocf3449.8PLA2G6, PLA2G1B
10lysophospholipid449.7PLA2G6, PLA2G1B
11hydrocortisone44 2 61 1112.7LTF, PLA2G6, IFNG
12aristolochic acid44 210.6PLA2G6, PLA2G1B
13leukotriene b444 61 2411.6LTF, PLA2G1B, MMP9
14simvastatin44 50 61 28 24 1114.6IFNG, MMP9, LIPA
15ltd4449.6PLA2G1B, PLA2G6
16endotoxin449.4LTF, PLA2G1B, IFNG
17actinomycin d449.4LTF, PLA2G6, IFNG, MMP9
18adenylate449.4LTF, PLA2G6, MMP9, LIPA
19cyclosporin a44 28 6111.4MMP9, IFNG, PLA2G6, LTF
20prostaglandin449.3PLA2G1B, PLA2G6, MMP9
21LysoPC(O-18:0)249.3PLA2G1B, PLA2G6
22indomethacin44 28 61 1112.3IFNG, PLA2G6, PLA2G1B, LTF
23phosphatidylcholine449.2PLA2G6, PLA2G1B, LTF
24cysteine449.0LIPA, MMP9, IFNG, PLA2G6, LTF
25pge2448.9LTF, PLA2G1B, PLA2G6, IFNG, MMP9
26dexamethasone44 50 28 1111.9MMP9, IFNG, PLA2G6, PLA2G1B, LTF

GO Terms for genes affiliated with Blepharitis

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Cellular components related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.9LACRT, PLA2G1B, LTF
2extracellular regionGO:0055768.5LTF, PLA2G1B, IFNG, MMP9, LACRT
3extracellular spaceGO:0056157.8LTF, CST4, PLA2G1B, IFNG, MMP9, LACRT

Biological processes related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylcholine acyl-chain remodelingGO:0361519.6PLA2G1B, PLA2G6
2phosphatidylethanolamine acyl-chain remodelingGO:0361529.3PLA2G1B, PLA2G6

Molecular functions related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Blepharitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet