MCID: BLP005
MIFTS: 42

Blepharitis malady

Eye diseases category

Summaries for Blepharitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Blepharitis (/blɛfərˈaɪtɨs/ BLEF-ər-EYE-tis) is an eye condition characterized by chronic... more...

MalaCards: Blepharitis is related to conjunctivitis and ulcerative blepharitis. An important gene associated with Blepharitis is LTF (lactotransferrin), and among its related pathways is Spinal Cord Injury. The compounds tranilast and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes.

Aliases & Classifications for Blepharitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

blepharitis 8 10 44 60


Related Diseases for Blepharitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Blepharitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.4
2ulcerative blepharitis10.3
3herpes simplex10.2
4lupus erythematosus10.2
5rosacea10.1
6squamous blepharitis10.1
7blepharoconjunctivitis10.1
8keratosis follicularis spinulosa decalvans, x-linked10.1
9gingivitis10.0LTF
10otitis media10.0LTF
11sjogren's syndrome10.0LTF
12keratoconjunctivitis sicca10.0LTF
13amyloidosis10.0LYZ
14strongyloidiasis10.0SHE
15keratosis follicularis spinulosa decalvans10.0SAT1
16ulcerative colitis10.0LYZ, LTF
17pleurisy10.0PLA2G6
18periodontal disease10.0LYZ, LTF, CST4
19peritonitis10.0PLA2G6
20keratosis follicularis10.0MBTPS2, SAT1
21crohn's disease10.0LTF, LYZ
22pulmonary emphysema10.0MMP9
23periodontitis10.0MMP9
24hypersensitivity reaction type ii disease10.0LTF, LYZ
25acne10.0
26allergic conjunctivitis10.0
27bacterial conjunctivitis10.0
28dermatitis10.0
29eye disease10.0
30leukonychia totalis10.0
31odontoonychodermal dysplasia10.0
32epidermolysis bullosa dystrophica, ar10.0
33xeroderma pigmentosum, group a10.0
34sarcoidosis10.0IFNG, LYZ
35fibrosarcoma10.0MMP9
36meningitis10.0MMP9, LYZ
37septic shock10.0PLA2G1B, LTF, PLA2G6
38monocytic leukemia10.0IFNG, LTF
39acute pancreatitis10.0PLA2G1B, PLA2G6, SAT1
40tropical spastic paraparesis10.0IFNG, MMP9
41relapsing-remitting multiple sclerosis10.0IFNG, MMP9
42atherosclerosis10.0LIPA, PLA2G1B, PLA2G6, MMP9
43arthritis10.0LYZ, PLA2G1B, PLA2G6, MMP9, IFNG, LTF
44sjogren-larsson syndrome9.8
45nodular nonsuppurative panniculitis9.8
46relapsing polychondritis9.8
47melkersson-rosenthal syndrome9.8
48junctional epidermolysis bullosa9.8
49ladd syndrome9.8
50sea-blue histiocyte syndrome9.8

Graphical network of the top 20 diseases related to Blepharitis:



Diseases related to blepharitis

Clinical Features for Blepharitis

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Drugs & Therapeutics for Blepharitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Blepharitis

Drug clinical trials:

Search ClinicalTrials for Blepharitis

Search NIH Clinical Center for Blepharitis

Search CenterWatch for Blepharitis

Genetic Tests for Blepharitis

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Anatomical Context for Blepharitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Blepharitis:

32
Eye, Skin, Testes

Animal Models for Blepharitis or affiliated genes

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Publications for Blepharitis

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50PubMed
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Articles related to Blepharitis:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Assessment of signs of anterior blepharitis using standardized color photographs. (24055901)
2013
2
Bacillus oleronius and Demodex mite infestation in patients with chronic blepharitis. (22114987)
2012
3
Oral azithromycin for treatment of posterior blepharitis. (21849891)
2011
4
Tear cytokines and chemokines in patients with Demodex blepharitis. (21050771)
2011
5
Bilateral upper and lower eyelid severe psoriasiform blepharitis: case report and review of literature. (21464793)
2011
6
Current evidence for topical azithromycin 1% ophthalmic solution in the treatment of blepharitis and blepharitis-associated ocular dryness. (21897139)
2011
7
Blepharitis. (20590417)
2010
8
Blepharitis and trichomegaly induced by cetuximab. (21308323)
2010
9
Reducing the rate of cataract surgery cancellation due to blepharitis. (19575031)
2010
10
Chronic blepharitis caused by Demodex folliculorum mites. (19291177)
2009
11
Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells. (19520694)
2009
12
The effects of blepharitis on ocular surgery. (19383272)
2009
13
Trace elements and blepharitis. (19356972)
2009
14
Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment. (19383269)
2009
15
Dry eye and blepharitis: approaching the patient with chronic eye irritation. (19572764)
2009
16
Canine conjunctivitis and blepharitis. (18299005)
2008
17
Diabetes as a possible predisposer for blepharitis. (18711470)
2008
18
Comparison of incidence of Demodex folliculorum on the eyelash follicule in normal people and blepharitis patients. (18224620)
2007
19
Blepharitis, allergy, and dry eye: lumpers and splitters. (17209246)
2006
20
Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. (15952718)
2005
21
Is it blepharitis? (15807644)
2005
22
Cluster analysis of patients with ocular surface disease, blepharitis, and dry eye. (15534133)
2004
23
Relapsing blepharitis in patients under highly active antiretroviral therapy including indinavir. (15075566)
2004
24
Eyelid disorders: the meibomian gland, blepharitis, and contact lenses. (12772741)
2003
25
Treatment of atopic blepharitis by controlling eyelid skin water retention ability with ceramide gel application. (12598457)
2003
26
Ocular tolerance and efficiency of two solutions applied to non-infectious blepharitis. (12120608)
2002
27
Ophthaproblem. Blepharitis. (11153404)
2000
28
Pyogranulomatous blepharitis in two dogs. (10701192)
2000
29
Enhanced secretory group II PLA2 activity in the tears of chronic blepharitis patients. (10509674)
1999
30
Dry eye, blepharitis and chronic eye irritation: divide and conquer. (10633658)
1999
31
Comparative evaluation of the short-term bactericidal potential of a steroid-antibiotic combination versus steroid in the treatment of chronic bacterial blepharitis and conjunctivitis. (8997575)
1996
32
Recurrence of herpes simplex virus blepharitis after cesarean section and epidural morphine. (8610878)
1996
33
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
34
Chronic blepharitis, meibomitis and corneal lesions. (7952336)
1993
35
Lid flora in blepharitis. (2019106)
1991
36
Role of cell-mediated immunity to staphylococci in blepharitis. (2012150)
1991
37
Treatment of chronic blepharitis. (3369983)
1988
38
Tear lysozyme measurements in chronic blepharitis. (3977218)
1985
39
Methicillin-resistant Staphylococcus epidermidis blepharitis. (6568091)
1984
40
Chemical blepharitis following drug treatment. (6846461)
1983
41
Classification of chronic blepharitis. (6218459)
1982
42
Phthiriasis palpebrarum - an unusual cause of blepharitis. (7265036)
1981
43
Staphylococcal blepharitis. (324453)
1977
44
The treatment of blepharitis: a controlled double blind study of combination therapy. (4567181)
1973
45
Blepharitis and related conditions. (4236660)
1969
46
Complications of staphylococcic blepharitis. (5807673)
1969
47
Angular blepharitis in ariboflavinosis, a not well known clinical manifestation of riboflavin deficiency. (18914530)
1948
48
Etiology and treatment of blepharitis; a study in military personnel. (21002032)
1946
49
THE SIGNIFICANCE OF ERRORS OF REFRACTION IN CHRONIC BLEPHARITIS OF CHILDREN. (18169606)
1939
50
THE X-RAY TREATMENT OF BLEPHARITIS. (18169233)
1934

Genetic Variations for Blepharitis

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Expression for genes affiliated with Blepharitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blepharitis

Search GEO for disease gene expression data for Blepharitis.

Pathways for genes affiliated with Blepharitis

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37NCBI BioSystems Database
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Pathways related to Blepharitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLA2G6, MMP9

Compounds for genes affiliated with Blepharitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Blepharitis according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1tranilast4410.0IFNG, MMP9
2scalaradial4410.0PLA2G1B, PLA2G6
3manoalide449.9PLA2G1B, PLA2G6
4succinate449.9MMP9, LTF, PLA2G6
5p-bromophenacyl bromide449.9PLA2G6, PLA2G1B
6ribavirin44 49 1111.9LTF, IFNG, MMP9
7melittin449.9PLA2G6, PLA2G1B
8Alpha-D-Mannose119.8LTF, PLA2G1B, LYZ
9lysophospholipid449.8PLA2G1B, PLA2G6
10aacocf3449.7PLA2G6, PLA2G1B
11hydrocortisone44 2 59 1112.6PLA2G6, LTF, IFNG
12aristolochic acid44 210.6PLA2G6, PLA2G1B
13leukotriene b444 59 2411.6LTF, MMP9, PLA2G1B
14simvastatin44 49 59 28 11 2414.5MMP9, IFNG, LIPA
15sb 20358044 5910.4SAT1, IFNG, MMP9, PLA2G6
16ltd4449.3PLA2G1B, PLA2G6
17indomethacin44 59 28 1112.3LTF, PLA2G1B, PLA2G6, IFNG
18actinomycin d449.3MMP9, LTF, SAT1, IFNG, PLA2G6
19cyclosporin a44 28 5911.1PLA2G6, LTF, IFNG, MMP9
20dexamethasone44 49 28 1111.9LTF, PLA2G1B, PLA2G6, MMP9, IFNG
21pge2448.7PLA2G1B, IFNG, SAT1, LTF, MMP9, PLA2G6

GO Terms for genes affiliated with Blepharitis

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16Gene Ontology
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Cellular components related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.0LTF, PLA2G1B, LACRT
2extracellular regionGO:0055767.9IFNG, CST4, LTF, MMP9, PLA2G1B, LACRT

Biological processes related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylethanolamine acyl-chain remodelingGO:0361529.6PLA2G1B, PLA2G6
2defense response to bacteriumGO:0427429.3LYZ, LTF, IFNG
3endoplasmic reticulum unfolded protein responseGO:0309689.3MBTPS2, IFNG, WIPI1

Molecular functions related to Blepharitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.6PLA2G1B, PLA2G6

Products for genes affiliated with Blepharitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blepharitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet