MCID: BLN003
MIFTS: 54

Blindness malady

Eye category

Summaries for Blindness

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Blindness is the condition of lacking visual perception due to physiological or neurological factors.... more...

MalaCards: Blindness, also known as blind vision, is related to congenital stationary night blindness and x-linked congenital stationary night blindness. An important gene associated with Blindness is PDE6B (phosphodiesterase 6B, cGMP-specific, rod, beta), and among its related pathways are Signaling by GPCR and Visual phototransduction. The compounds cgmp and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Blindness

Sources:
10DISEASES, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

blindness 10 45
blind vision 61


Related Diseases for Blindness

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the congenital blindness due to retinal non-attachment family:

blindness

Diseases related to Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1235)
idRelated DiseaseScoreTop Affiliating Genes
1congenital stationary night blindness31.1CACNA1F, PDE6B, RDH5, RHO, GRK1, NYX
2x-linked congenital stationary night blindness30.5CACNA1F, NYX
3hereditary night blindness30.3NYX, SAG, CACNA1F
4leber congenital amaurosis30.2PDE6B, RHO, AIPL1
5blue cone monochromacy30.0OPN1MW, OPN1LW
6achromatopsia29.9CNGA3, NYX
7oguchi disease 129.9CACNA1F, SAG, RDH5, RHO, GRK1, NYX
8fundus albipunctatus29.9CACNA1F, RDH5
9congenital nystagmus29.8CNGA3, CABP4
10cone-rod dystrophy 229.6RHO, AIPL1
11hyperopia29.6CACNA1F
12red-green color vision defects29.4OPN1MW, OPN1LW
13cortical blindness10.9
14blind loop syndrome10.6
15arthritis10.6
16trachoma10.4
17asthma10.4
18n syndrome10.4
19schizoaffective disorder10.4
20hepatitis b10.4
21hepatitis d10.4
22hepatitis c10.4
23chronic pain10.4
24onchocerciasis10.4
25common cold10.4
26premature ejaculation10.4
27anxiety disorder10.4
28hepatitis a10.4
29bipolar disorder10.4
30major depressive disorder10.4
31cocaine dependence10.4
32allergic rhinitis10.3
33osteoarthritis10.3
34tinea pedis10.3
35acne10.3
36back pain10.3
37generalized anxiety disorder10.3
38hypercholesterolemia10.3
39sepsis10.3
40stomatitis10.3
41postherpetic neuralgia10.3
42acute diarrhea10.3
43autistic disorder10.3
44cervical dystonia10.3
45aphthous stomatitis10.3
46acute myocardial infarction10.3
47eclampsia10.3
48epicondylitis10.3
49xerophthalmia10.3
50fibromyalgia10.3

Graphical network of the top 20 diseases related to Blindness:



Diseases related to blindness

Clinical Features for Blindness

Drugs & Therapeutics for Blindness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Blindness

Drug clinical trials:

Search ClinicalTrials for Blindness

Search NIH Clinical Center for Blindness

Search CenterWatch for Blindness

Genetic Tests for Blindness

Anatomical Context for Blindness

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Blindness:

33
Bone marrow, Whole blood, Brain, Cortex, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Placenta, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Parietal lobe, Temporal lobe, Occipital lobe, Amygdala, Tongue, Bronchial epithelium, Adrenal cortex, Pineal, Pituitary

Animal Models for Blindness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Blindness:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539112.5NYX, CABP4, CACNA1F, GNAT1, SAG, PDE6B
2MP:000363112.1CACNA1F, GNAT1, SAG, PDE6B, OPN1SW, OPA1

Publications for Blindness

Sources:
51PubMed
See all sources

Articles related to Blindness:

(show top 50)    (show all 1603)
idTitleAuthorsYear
1
Case of acquired night blindness in a hemodialysis patient. (24314428)
2013
2
Facial Disfigurement: Restoration of Facial Dynamics in a Patient with Concomitant Facial Paralysis and Blindness. (24114708)
2013
3
Episodic blindness and ataxia in a horse with cholesterinic granulomas. (22624528)
2013
4
Choosing in freedom or forced to choose? Introspective blindness to psychological forcing in stage-magic. (23516455)
2013
5
Using acoustic information to perceive room size: effects of blindness, room reverberation time, and stimulus. (24386717)
2013
6
Change blindness in children with ADHD: a selective impairment in visual search? (22334620)
2013
7
A rapid assessment of avoidable blindness in Southern Zambia. (22737211)
2012
8
Mutation screening of TRPM1, GRM6, NYX and CACNA1F genes in patients with congenital stationary night blindness. (22735794)
2012
9
Blindness in a pulseless young woman: lessons learned. (22646739)
2012
10
Attenuation of change blindness in children with autism spectrum disorders. (22882373)
2012
11
Changing trends in the prevalence of blindness and visual impairment in a rural district of India: systematic observations over a decade. (22944766)
2012
12
"Doing it blindfolded"-successful administration of enfuvirtide by a person living with HIV and blindness: a case study of treatment access and disability. (22243977)
2012
13
Transient cortical blindness post angiography--a case report. (22224355)
2011
14
Potential for linezolid-related blindness: a review of spontaneous adverse event reports. (21923442)
2011
15
The neural substrates associated with inattentional blindness. (21481608)
2011
16
Methomyl-alphamethrin poisoning presented with cholinergic crisis, cortical blindness, and delayed peripheral neuropathy. (20923394)
2010
17
The incidence of color blindness among some school children of Pokhara, Western Nepal. (20677611)
2010
18
Neuroaspergillosis leading to blindness in a patient with multiple myeloma. (19884809)
2010
19
Primary CNS lymphoma presenting with acute blindness and encephalocele. (18235130)
2008
20
Onchocerciasis (river blindness). Report from the sixteenth InterAmerican Conference on Onchocerciasis, Antigua Guatemala, Guatemala. (17763565)
2007
21
Partial recovery from cortical blindness following carbon monoxide intoxication. (15768859)
2005
22
Trachoma: leading cause of infectious blindness. (15078842)
2004
23
Rapid recovery of night blindness due to obesity surgery after vitamin A repletion therapy. (15031184)
2004
24
Ocular and cutaneous squamous cell carcinoma in an African American man with epidermodysplasia verruciformis resulting in blindness and death. (14576647)
2003
25
Congenital stationary night blindness in briards in the UK. (11334084)
2001
26
Onchocerciasis (river blindness). (11218695)
2001
27
Monitoring for the emergence of new foci of onchocerciasis (river blindness) in the Americas. (10748915)
2000
28
Cortical blindness as a manifestation of hypomagnesemia secondary to cisplatin therapy: case report and review of literature. (9889044)
1999
29
Working after the sun goes down: exploring how night blindness impairs women's work activities in rural Nepal. (9683335)
1998
30
Transient cortical blindness in liver cirrhosis. (9512132)
1998
31
Transient cortical blindness in gestational hypertension: report of two cases. (9103699)
1996
32
Cortical blindness in a 35-year-old man. (8733542)
1996
33
'On mind-blindness (optic agnosia)', a classical clinico-pathological report, and its author Wilhelm von Stauffenberg (1879-1918). (11619040)
1996
34
Cortical blindness after a failed free tissue transfer: a case report and review of the literature. (7793793)
1995
35
Progressive multifocal leukoencephalopathy (PML) in two cases of cortical blindness. (11362130)
1994
36
Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness. (8075643)
1994
37
Late retrobulbar hemorrhage and blindness following malar fracture complicated by factor XI deficiency. (8492213)
1993
38
Interferon-related cortical blindness. (1537083)
1992
39
Temporal arteritis. A preventable cause of blindness. (2275664)
1990
40
The molecular basis of retinoic acid induced night blindness. (2660792)
1989
41
Possible pathogenesis of congenital stationary night blindness. (3498070)
1987
42
Congenital stationary night blindness. (3487908)
1986
43
X-linked recessive congenital stationary night blindness, myopia, and tilted discs. (6972443)
1981
44
Cortical blindness in puerperium. (7359663)
1980
45
Human color vision and color blindness. (4956617)
1965
46
Intracranial aneurysm causing panhypopituitarism, blindness, seizures, and dementia. (13947970)
1962
47
Preventable blindness: iritis. (14486093)
1961
48
Cortical blindness. (13525992)
1958
49
"Night-blindness"-A Psycho-physiological Study-II. (20783934)
1941
50
Color-Blindness. (17748195)
1889

Genetic Variations for Blindness

Expression for genes affiliated with Blindness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Blindness

Search GEO for disease gene expression data for Blindness.

Pathways for genes affiliated with Blindness

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Blindness

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Blindness according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cgmp45 2912.4SAG, PDE6B, RHO, GRK1, CNGA3
2vitamin a45 11 2413.4SAG, RDH5, RHO, GRK1, AIPL1
3calcium45 50 11 2414.3CACNA1F, SAG, PDE6B, OPN1LW, GRK1, TRPM1
4metarhodopsin ii4511.2GRK1, RHO, SAG
5phosphorhodopsin4510.9RHO, SAG
6gramicidin4510.9SLC24A1, RHO
7phytate4510.9SAG, GRK1
811-cis-retinol45 2411.8RHO, RDH5
9guanylate4510.8SAG, RHO, GRK1
10bacteriorhodopsin4510.8RHO, OPN1SW
11hydroxylamine4510.8RHO, SAG

GO Terms for genes affiliated with Blindness

Sources:
16Gene Ontology
See all sources

Cellular components related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.3OPN1LW, RHO, TRPM1, CNGA3, SLC24A1, OPN1SW
2photoreceptor disc membraneGO:09738111.1GRK1, RHO, PDE6B, GNAT1
3photoreceptor outer segment membraneGO:04262211.1GNAT1, OPN1SW, OPN1LW, RHO
4photoreceptor inner segmentGO:00191711.0GNAT1, SAG, RHO, AIPL1
5photoreceptor outer segmentGO:00175010.8CNGA3, RHO, SAG, GNAT1

Biological processes related to Blindness according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760113.3NYX, CACNA1F, CABP4, GNAT1, SAG, SLC24A1
2phototransduction, visible lightGO:00760312.3SLC24A1, CNGA3, AIPL1, GRK1, RHO, OPN1LW
3rhodopsin mediated signaling pathwayGO:01605611.6GNAT1, SAG, PDE6B, RHO, GRK1, SLC24A1
4regulation of rhodopsin mediated signaling pathwayGO:02240011.4GNAT1, SAG, PDE6B, RHO, GRK1
5retina development in camera-type eyeGO:06004111.2RHO, PDE6B, GNAT1, CACNA1F
6retinoid metabolic processGO:00152311.2RDH5, OPN1SW, OPN1LW, RHO
7protein-chromophore linkageGO:01829811.0RHO, OPN1LW, OPN1SW
8photoreceptor cell morphogenesisGO:00859410.8GRK1, CABP4
9response to light intensityGO:00964210.8GNAT1, SLC24A1
10phototransductionGO:00760210.8OPN1SW, CABP4
11retinal cone cell developmentGO:04654910.7CNGA3, CABP4
12detection of light stimulus involved in visual perceptionGO:05090810.5GNAT1, CACNA1F

Molecular functions related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:00988110.9RHO, OPN1LW, OPN1SW

Products for genes affiliated with Blindness

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blindness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet