MCID: BLN003
MIFTS: 47

Blindness malady

Eye diseases, Rare diseases categories

Aliases & Classifications for Blindness

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Sources:
11DISEASES, 43Novoseek, 60UMLS
See all sources

Blindness, Aliases & Descriptions:

Name: Blindness 11 43
 
Blind Vision 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Summaries for Blindness

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Wikipedia:63 Blindness is the condition of poor visual perception. more...

MalaCards based summary: Blindness, also known as blind vision, is related to x-linked congenital stationary night blindness and retinitis. An important gene associated with Blindness is PDE6B (phosphodiesterase 6B, cGMP-specific, rod, beta), and among its related pathways are Opsins and Calcium channels. The compounds bacteriorhodopsin and phosphorhodopsin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and testes, and related mouse phenotypes are nervous system and vision/eye.

Related Diseases for Blindness

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Diseases in the Blindness family:

Congenital Blindness Due to Retinal Non-Attachment

Diseases related to Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1457)
idRelated DiseaseScoreTop Affiliating Genes
1x-linked congenital stationary night blindness31.3NYX, CACNA1F
2retinitis31.1RHO, SAG
3congenital stationary night blindness30.9NYX, CACNA1F, PDE6B, RHO, GRK1
4fundus albipunctatus30.7CACNA1F
5leber congenital amaurosis30.7RHO, PDE6B
6hereditary night blindness30.5NYX, SAG, CACNA1F
7myopia30.5NYX, CACNA1F
8hyperopia30.3CACNA1F
9aland island eye disease29.9NYX, CACNA1F
10uveitis29.9RHO, SAG
11retinal degeneration29.8SAG, PDE6B, RHO, GRK1
12night blindness29.7GPR179, GNAT1, NYX, SAG, CACNA1F, CABP4
13fundus dystrophy29.6GRK1, RHO
14retinitis pigmentosa autosomal recessive29.5GRK1, RHO, PDE6B, SAG
15cortical blindness10.9
16color blindness10.8
17schizophrenia10.6
18blind loop syndrome10.6
19arthritis10.6
20hepatitis10.5
21rheumatoid arthritis10.5
22cerebritis10.5
23cervicitis10.5
24prostatitis10.5
25trachoma10.5
26neuropathy10.5
27premature ejaculation10.4
28onchocerciasis10.4
29rhinitis10.4
30asthma10.4
31common cold10.4
32anxiety disorder10.4
33diarrhea10.4
34astigmatism10.4CACNA1F
35obesity10.4
36cocaine dependence10.4
37tinea pedis10.4
38bipolar i disorder10.4
39dystonia10.4
40endogenous depression10.4
41acne10.4
42osteoarthritis10.4
43generalized anxiety disorder10.4
44back pain10.4
45allergic rhinitis10.3
46postherpetic neuralgia10.3
47breast cancer10.3
48cervical dystonia10.3
49conjunctivitis10.3
50stomatitis10.3

Graphical network of the top 20 diseases related to Blindness:



Diseases related to blindness

Symptoms for Blindness

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Drugs & Therapeutics for Blindness

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Drug clinical trials:

Search ClinicalTrials for Blindness

Search NIH Clinical Center for Blindness

Genetic Tests for Blindness

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Anatomical Context for Blindness

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MalaCards organs/tissues related to Blindness:

31
Eye, Bone, Testes, Heart, Prostate, Liver, Brain, Breast, Skin, Lung, Endothelial, Pituitary, Bone marrow, Ovary, Thyroid, Spinal cord, Colon, Cortex, Tonsil, Retina, Uterus, T cells, Kidney, Pancreas, Small intestine, Myeloid, Neutrophil, Skeletal muscle, B cells, Occipital lobe, Placenta, Monocytes, Tongue, Whole blood, Spleen, Globus pallidus, Amygdala, Pineal

Animal Models for Blindness or affiliated genes

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MGI Mouse Phenotypes related to Blindness:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.5SAG, CACNA1F, CABP4, PDE6B, RHO, GRK1
2MP:00053916.0TRPM1, GPR179, GNAT1, NYX, SAG, CACNA1F

Publications for Blindness

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Articles related to Blindness:

(show top 50)    (show all 5575)
idTitleAuthorsYear
1
Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial. (25907158)
2015
2
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial. (23821414)
2013
3
Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study. (23624890)
2013
4
BB-UVA vs. NB-UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded). (24001379)
2013
5
The effect of short-term low-energy ultraviolet B irradiation on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis: a randomized single-blinded controlled clinical trial. (24364223)
2013
6
Cortical Blindness due to Bilateral Occipital Infarcts in a Renal Failure Patient with Prostate Cancer: A Rare Complication of Hemodialysis. (23424594)
2013
7
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
8
Diffusion tensor imaging reveals normal geniculocalcarine-tract integrity in acquired blindness. (22560504)
2012
9
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
10
A rapid assessment of avoidable blindness in Southern Zambia. (22737211)
2012
11
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
12
Isolated transient blindness and isolated oculomotor nerve palsy secondary to single mesencephalic metastases: report of 2 cases. (22267452)
2012
13
Spontaneous intracranial hypotension: efficacy of radiologic targeting vs blind blood patch. (21444899)
2011
14
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. (21677899)
2011
15
Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial. (20133204)
2010
16
Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. (20629075)
2010
17
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
18
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. (18644685)
2009
19
Vitamin A responsive night blindness in Dent's disease. (19444483)
2009
20
Ibandronate prevents bone loss and reduces vertebral fracture risk in male cardiac transplant patients: a randomized double-blind, placebo-controlled trial. (19257824)
2009
21
Maize food allergy: a double-blind placebo-controlled study. (18778272)
2008
22
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
23
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
24
Results of double-blind placebo-controlled crossover study of sildenafil citrate (Viagra) in women suffering from obstructed voiding or retention associated with the primary disorder of sphincter relaxation (Fowler's Syndrome). (16884844)
2007
25
Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: a double-blind, crossover, placebo-controlled pilot study. (16579999)
2006
26
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
27
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
28
Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a preliminary blind-rater study. (16282845)
2005
29
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
30
The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study. (14671179)
2003
31
Results of double-blind placebo-controlled challenge with nickel salts in patients affected by recurrent aphthous stomatitis. (12915773)
2003
32
Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. (11910270)
2002
33
A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. (12385443)
2002
34
Effects of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): double-blind randomized trial]. (11675825)
2001
35
Albendazole for treatment and prophylaxis of microsporidiosis due to Encephalitozoon intestinalis in patients with AIDS: a randomized double-blind controlled trial. (9593027)
1998
36
Endocrine secretions under abnormal light-dark cycles and in the blind. (9550117)
1998
37
Transient cortical blindness in preeclampsia with indication of generalized vascular endothelial damage. (9736196)
1998
38
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
39
Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. (8558148)
1996
40
A double-blind, placebo-controlled, dose-finding trial of intermittent nasal salmon calcitonin for prevention of postmenopausal lumbar spine bone loss. (7733123)
1995
41
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
42
Double-blind randomized phase I study on the clinical tolerance and biological effects of natural and recombinant interferon-beta. (1431312)
1992
43
A double-blind study comparing a new non-ergot, long-acting dopamine agonist, CV 205-502, with bromocriptine in women with hyperprolactinaemia. (1973085)
1990
44
VEP and EEG in cortical blindness: a case with a complicated course. (2081688)
1990
45
Treatment of chronic moccasin-type tinea pedis with terbinafine: a double-blind, placebo-controlled trial. (2229528)
1990
46
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
47
Betahistine in peripheral vertigo: a double-blind, placebo-controlled, cross-over study of Serc versus placebo. (7019369)
1981
48
A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis. (881743)
1977
49
Blindness following relief of increased intracranial pressure. A sequel to severe papilledema. (5471329)
1970
50
Industrial use of the Ishihara tests for color blindness. (20288890)
1947

Variations for Blindness

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Expression for genes affiliated with Blindness

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Search GEO for disease gene expression data for Blindness.

Pathways for genes affiliated with Blindness

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Compounds for genes affiliated with Blindness

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Blindness according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1bacteriorhodopsin4310.0RHO, OPN1SW
2phosphorhodopsin439.9SAG, RHO
3hydroxylamine439.7RHO, SAG
4gramicidin439.6SLC24A1, RHO
5phytate439.5GRK1, SAG
6leucine439.4RHO, PDE6B, SAG
7opiate439.4RHO, SAG
8metarhodopsin ii439.3GRK1, RHO, SAG
9guanylate439.2GRK1, RHO, SAG
10vitamin a43 24 1211.1GRK1, RHO, SAG
11cgmp43 2810.0GRK1, RHO, PDE6B, SAG
12calcium43 49 24 1210.3SAG, CACNA1F, PDE6B, GRK1, SLC24A1, TRPM1

GO Terms for genes affiliated with Blindness

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Cellular components related to Blindness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor inner segmentGO:00019179.7GNAT1, RHO
2photoreceptor outer segment membraneGO:00426229.6GNAT1, RHO, OPN1SW
3photoreceptor outer segmentGO:00017509.5RHO, CACNA1F, GNAT1
4photoreceptor disc membraneGO:00973819.0GRK1, RHO, PDE6B, GNAT1
5integral component of plasma membraneGO:00058878.3TRPM1, SLC24A1, OPN1SW, RHO
6plasma membraneGO:00058867.8GNAT1, PDE6B, RHO, SLC24A1, TRPM1, GPR179

Biological processes related to Blindness according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1retinoid metabolic processGO:00015239.9OPN1SW, RHO
2protein-chromophore linkageGO:00182989.8RHO, OPN1SW
3detection of light stimulus involved in visual perceptionGO:00509089.8CACNA1F, GNAT1
4photoreceptor cell morphogenesisGO:00085949.6CABP4, GRK1
5phototransductionGO:00076029.6OPN1SW, CABP4
6retina development in camera-type eyeGO:00600419.4RHO, PDE6B, CACNA1F, GNAT1
7response to light intensityGO:00096429.3SLC24A1, GNAT1
8regulation of rhodopsin mediated signaling pathwayGO:00224008.6GNAT1, SAG, PDE6B, RHO, GRK1
9rhodopsin mediated signaling pathwayGO:00160567.8GNAT1, SAG, PDE6B, RHO, GRK1, SLC24A1
10phototransduction, visible lightGO:00076037.5GNAT1, SAG, PDE6B, RHO, GRK1, OPN1SW
11visual perceptionGO:00076015.7TRPM1, GPR179, GNAT1, NYX, SAG, CACNA1F

Molecular functions related to Blindness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:00098819.9OPN1SW, RHO

Products for genes affiliated with Blindness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Blindness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet