MCID: BLN003
MIFTS: 37

Blindness malady

Eye diseases category

Summaries for Blindness

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63Wikipedia, 32MalaCards
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Wikipedia:63 Blindness is the condition of lacking visual perception due to physiological or neurological factors.... more...

MalaCards: Blindness, also known as blind vision, is related to night blindness and color blindness. An important gene associated with Blindness is PDE6B (phosphodiesterase 6B, cGMP-specific, rod, beta), and among its related pathways are Signaling by GPCR and Visual phototransduction. The compounds cgmp and vitamin a have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Blindness

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Sources:
10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

blindness 10 44
blind vision 60


Related Diseases for Blindness

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Congenital Blindness Due to Retinal Non-Attachment family:

blindness

Diseases related to Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1313)
idRelated DiseaseScoreTop Affiliating Genes
1night blindness31.3CABP4, CACNA1F, GNAT1, SAG, PDE6B, RDH5
2color blindness31.1CNGA3
3congenital stationary night blindness31.1CACNA1F, PDE6B, RDH5, RHO, GRK1, NYX
4retinitis30.7RHO, RDH5, SAG
5x-linked congenital stationary night blindness30.4CACNA1F, NYX
6eye disease30.3RHO, SAG
7hereditary night blindness30.3NYX, SAG, CACNA1F
8retinal disease30.2RHO, GRK1, AIPL1, CNGA3, NYX, OPA1
9leber congenital amaurosis30.1PDE6B, RHO, AIPL1
10chorioretinitis30.1SAG
11blue cone monochromacy30.0OPN1MW, OPN1LW
12oguchi disease 130.0CACNA1F, SAG, RDH5, RHO, GRK1, NYX
13retinal degeneration29.9SAG, PDE6B, RDH5, RHO, GRK1, AIPL1
14achromatopsia29.9CNGA3, NYX
15fundus albipunctatus29.8CACNA1F, RDH5
16congenital nystagmus29.7CNGA3, CABP4
17cone-rod dystrophy 229.6RHO, AIPL1
18fundus dystrophy29.4RDH5, RHO, GRK1, AIPL1, CNGA3
19red-green color vision defects29.4OPN1MW, OPN1LW
20aland island eye disease29.4CACNA1F, NYX
21cortical blindness10.9
22hypertension10.6
23schizophrenia10.6
24blind loop syndrome10.6
25arthritis10.5
26hepatitis10.5
27rheumatoid arthritis10.5
28cerebritis10.4
29multiple sclerosis10.4
30hepatitis a10.4
31trachoma10.4
32cervicitis10.4
33prostatitis10.4
34neuropathy10.4
35schizoaffective disorder10.4
36diabetes mellitus10.4
37rhinitis10.4
38onchocerciasis10.4
39common cold10.4
40premature ejaculation10.4
41anxiety disorder10.4
42asthma10.4
43bipolar disorder10.4
44diarrhea10.3
45major depressive disorder10.3
46cocaine dependence10.3
47obesity10.3
48allergic rhinitis10.3
49endogenous depression10.3
50osteoarthritis10.3

Graphical network of the top 20 diseases related to Blindness:



Diseases related to blindness

Clinical Features for Blindness

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Drugs & Therapeutics for Blindness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Blindness

Drug clinical trials:

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Search NIH Clinical Center for Blindness

Search CenterWatch for Blindness

Genetic Tests for Blindness

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Anatomical Context for Blindness

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Animal Models for Blindness or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Blindness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539112.5CABP4, AIPL1, GRK1, RHO, OPA1, OPN1SW
2MP:000363112.1AIPL1, GRK1, RHO, OPA1, OPN1SW, PDE6B

Publications for Blindness

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Genetic Variations for Blindness

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Expression for genes affiliated with Blindness

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blindness

Search GEO for disease gene expression data for Blindness.

Pathways for genes affiliated with Blindness

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Blindness

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Blindness according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cgmp44 2812.4SAG, PDE6B, RHO, GRK1, CNGA3
2vitamin a44 11 2413.4SAG, RDH5, RHO, GRK1, AIPL1
3calcium44 49 11 2414.3CACNA1F, SAG, PDE6B, OPN1LW, GRK1, TRPM1
4metarhodopsin ii4411.2GRK1, RHO, SAG
5phosphorhodopsin4410.9RHO, SAG
6gramicidin4410.9SLC24A1, RHO
7phytate4410.9SAG, GRK1
811-cis-retinol44 2411.8RHO, RDH5
9guanylate4410.8SAG, RHO, GRK1
10bacteriorhodopsin4410.8RHO, OPN1SW
11hydroxylamine4410.8RHO, SAG

GO Terms for genes affiliated with Blindness

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Sources:
16Gene Ontology
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Cellular components related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.3OPN1LW, RHO, TRPM1, CNGA3, SLC24A1, OPN1SW
2photoreceptor disc membraneGO:09738111.1GRK1, RHO, PDE6B, GNAT1
3photoreceptor outer segment membraneGO:04262211.1GNAT1, OPN1SW, OPN1LW, RHO
4photoreceptor inner segmentGO:00191711.0GNAT1, SAG, RHO, AIPL1
5photoreceptor outer segmentGO:00175010.8CNGA3, RHO, SAG, GNAT1

Biological processes related to Blindness according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760113.3NYX, CACNA1F, CABP4, GNAT1, SAG, SLC24A1
2phototransduction, visible lightGO:00760312.3SLC24A1, CNGA3, AIPL1, GRK1, RHO, OPN1LW
3rhodopsin mediated signaling pathwayGO:01605611.6GNAT1, SAG, PDE6B, RHO, GRK1, SLC24A1
4regulation of rhodopsin mediated signaling pathwayGO:02240011.4GNAT1, SAG, PDE6B, RHO, GRK1
5retina development in camera-type eyeGO:06004111.2RHO, PDE6B, GNAT1, CACNA1F
6retinoid metabolic processGO:00152311.2RDH5, OPN1SW, OPN1LW, RHO
7protein-chromophore linkageGO:01829811.0RHO, OPN1LW, OPN1SW
8photoreceptor cell morphogenesisGO:00859410.8GRK1, CABP4
9response to light intensityGO:00964210.8GNAT1, SLC24A1
10phototransductionGO:00760210.8OPN1SW, CABP4
11retinal cone cell developmentGO:04654910.7CNGA3, CABP4
12detection of light stimulus involved in visual perceptionGO:05090810.5GNAT1, CACNA1F

Molecular functions related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:00988110.9RHO, OPN1LW, OPN1SW

Products for genes affiliated with Blindness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blindness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet