MCID: BLN003
MIFTS: 52

Blindness malady

Eye diseases category

Summaries for Blindness

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Blindness is the condition of poor visual perception. more...

MalaCards: Blindness, also known as blind vision, is related to congenital stationary night blindness and night blindness. An important gene associated with Blindness is PDE6B (phosphodiesterase 6B, cGMP-specific, rod, beta), and among its related pathways are Opsins and Calcium channels. The compounds bacteriorhodopsin and phosphorhodopsin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Blindness

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Sources:
11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

blindness 11 46
blind vision 63


Related Diseases for Blindness

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Blindness:



Diseases related to blindness

Symptoms for Blindness

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Drugs & Therapeutics for Blindness

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Blindness

Drug clinical trials:

Search ClinicalTrials for Blindness

Search NIH Clinical Center for Blindness

Search CenterWatch for Blindness

Genetic Tests for Blindness

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Anatomical Context for Blindness

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Sources:
34MalaCards
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MalaCards organs/tissues related to Blindness:

34
Bone, Eye, Testes, Heart, Prostate, Liver, Breast, Brain, Skin, Lung, Endothelial, Pituitary, Bone marrow, Thyroid, Ovary, Tonsil, Spinal cord, Cortex, Colon, Uterus, T cells, Retina, Kidney, Pancreas, Small intestine, Myeloid, Occipital lobe, B cells, Monocytes, Tongue, Placenta, Skeletal muscle, Globus pallidus, Amygdala, Spleen, Pineal, Whole blood

Animal Models for Blindness or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Blindness:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.5SAG, CACNA1F, CABP4, PDE6B, RHO, GRK1
2MP:00053916.0TRPM1, GPR179, GNAT1, NYX, SAG, CACNA1F

Publications for Blindness

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53PubMed
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Articles related to Blindness:

(show top 50)    (show all 5293)
idTitleAuthorsYear
1
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial. (23821414)
2013
2
Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study. (23624890)
2013
3
BB-UVA vs. NB-UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded). (24001379)
2013
4
The effect of short-term low-energy ultraviolet B irradiation on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis: a randomized single-blinded controlled clinical trial. (24364223)
2013
5
Cortical Blindness due to Bilateral Occipital Infarcts in a Renal Failure Patient with Prostate Cancer: A Rare Complication of Hemodialysis. (23424594)
2013
6
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
7
Diffusion tensor imaging reveals normal geniculocalcarine-tract integrity in acquired blindness. (22560504)
2012
8
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
9
A rapid assessment of avoidable blindness in Southern Zambia. (22737211)
2012
10
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
11
Isolated transient blindness and isolated oculomotor nerve palsy secondary to single mesencephalic metastases: report of 2 cases. (22267452)
2012
12
Spontaneous intracranial hypotension: efficacy of radiologic targeting vs blind blood patch. (21444899)
2011
13
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. (21677899)
2011
14
Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial. (20133204)
2010
15
Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. (20629075)
2010
16
Vesicoureteral reflux and primary bladder neck dysfunction in children: urodynamic evaluation and randomized, double-blind, clinical trial on effect of I+-blocker therapy. (20850812)
2010
17
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. (18644685)
2009
18
Vitamin A responsive night blindness in Dent's disease. (19444483)
2009
19
Ibandronate prevents bone loss and reduces vertebral fracture risk in male cardiac transplant patients: a randomized double-blind, placebo-controlled trial. (19257824)
2009
20
Maize food allergy: a double-blind placebo-controlled study. (18778272)
2008
21
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
22
Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. (18209734)
2008
23
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
24
Results of double-blind placebo-controlled crossover study of sildenafil citrate (Viagra) in women suffering from obstructed voiding or retention associated with the primary disorder of sphincter relaxation (Fowler's Syndrome). (16884844)
2007
25
Sildenafil improves sexual functioning in premenopausal women with type 1 diabetes who are affected by sexual arousal disorder: a double-blind, crossover, placebo-controlled pilot study. (16579999)
2006
26
Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo. (15763607)
2005
27
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
28
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
29
The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study. (14671179)
2003
30
Results of double-blind placebo-controlled challenge with nickel salts in patients affected by recurrent aphthous stomatitis. (12915773)
2003
31
Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. (11910270)
2002
32
A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. (12385443)
2002
33
Effects of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): double-blind randomized trial]. (11675825)
2001
34
Albendazole for treatment and prophylaxis of microsporidiosis due to Encephalitozoon intestinalis in patients with AIDS: a randomized double-blind controlled trial. (9593027)
1998
35
Endocrine secretions under abnormal light-dark cycles and in the blind. (9550117)
1998
36
Transient cortical blindness in preeclampsia with indication of generalized vascular endothelial damage. (9736196)
1998
37
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
38
Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. (8558148)
1996
39
A double-blind, placebo-controlled, dose-finding trial of intermittent nasal salmon calcitonin for prevention of postmenopausal lumbar spine bone loss. (7733123)
1995
40
Cortical blindness and visual imagery. (8848191)
1995
41
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. (7881024)
1994
42
Double-blind randomized phase I study on the clinical tolerance and biological effects of natural and recombinant interferon-beta. (1431312)
1992
43
A double-blind study comparing a new non-ergot, long-acting dopamine agonist, CV 205-502, with bromocriptine in women with hyperprolactinaemia. (1973085)
1990
44
VEP and EEG in cortical blindness: a case with a complicated course. (2081688)
1990
45
Treatment of chronic moccasin-type tinea pedis with terbinafine: a double-blind, placebo-controlled trial. (2229528)
1990
46
Single dose oral treatment in urinary schistosomiasis: a double blind trial. (6401550)
1983
47
Betahistine in peripheral vertigo: a double-blind, placebo-controlled, cross-over study of Serc versus placebo. (7019369)
1981
48
A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis. (881743)
1977
49
Blindness following relief of increased intracranial pressure. A sequel to severe papilledema. (5471329)
1970
50
Industrial use of the Ishihara tests for color blindness. (20288890)
1947

Variations for Blindness

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Expression for genes affiliated with Blindness

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Blindness

Search GEO for disease gene expression data for Blindness.

Pathways for genes affiliated with Blindness

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Sources:
51PathCards, 56Reactome, 13EMD Millipore, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Blindness

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Blindness according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1bacteriorhodopsin4610.0RHO, OPN1SW
2phosphorhodopsin469.9SAG, RHO
3hydroxylamine469.7RHO, SAG
4gramicidin469.6SLC24A1, RHO
5phytate469.5GRK1, SAG
6leucine469.4RHO, PDE6B, SAG
7opiate469.4RHO, SAG
8metarhodopsin ii469.3GRK1, RHO, SAG
9guanylate469.2GRK1, RHO, SAG
10vitamin a46 25 1211.1GRK1, RHO, SAG
11cgmp46 3010.0GRK1, RHO, PDE6B, SAG
12calcium46 52 25 1210.3SAG, CACNA1F, PDE6B, GRK1, SLC24A1, TRPM1

GO Terms for genes affiliated with Blindness

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Sources:
17Gene Ontology
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Cellular components related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor inner segmentGO:0019179.7RHO, GNAT1
2photoreceptor outer segment membraneGO:0426229.6GNAT1, RHO, OPN1SW
3photoreceptor outer segmentGO:0017509.5RHO, CACNA1F, GNAT1
4photoreceptor disc membraneGO:0973819.0GNAT1, PDE6B, RHO, GRK1
5integral component of plasma membraneGO:0058878.3TRPM1, SLC24A1, OPN1SW, RHO
6plasma membraneGO:0058867.8TRPM1, SLC24A1, RHO, GPR179, GNAT1, PDE6B

Biological processes related to Blindness according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1retinoid metabolic processGO:0015239.9OPN1SW, RHO
2protein-chromophore linkageGO:0182989.8RHO, OPN1SW
3detection of light stimulus involved in visual perceptionGO:0509089.8CACNA1F, GNAT1
4photoreceptor cell morphogenesisGO:0085949.6CABP4, GRK1
5phototransductionGO:0076029.6OPN1SW, CABP4
6retina development in camera-type eyeGO:0600419.4GNAT1, RHO, PDE6B, CACNA1F
7response to light intensityGO:0096429.3SLC24A1, GNAT1
8regulation of rhodopsin mediated signaling pathwayGO:0224008.6GRK1, RHO, PDE6B, SAG, GNAT1
9rhodopsin mediated signaling pathwayGO:0160567.8RHO, PDE6B, GNAT1, SAG, SLC24A1, GRK1
10phototransduction, visible lightGO:0076037.5OPN1SW, SLC24A1, RHO, PDE6B, SAG, GNAT1
11visual perceptionGO:0076015.7SAG, GPR179, GNAT1, NYX, CACNA1F, CABP4

Molecular functions related to Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:0098819.9OPN1SW, RHO

Products for genes affiliated with Blindness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Blindness

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet