MCID: BLD051
MIFTS: 42

Blood Coagulation Disease malady

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and thrombophilia due to antithrombin iii deficiency. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Dalteparin have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 12.2
2 thrombophilia due to antithrombin iii deficiency 10.7
3 gray platelet syndrome 10.7
4 glycoprotein ia deficiency 10.7
5 bernard-soulier syndrome, type c 10.7
6 von willebrand disease, platelet-type 10.7
7 bleeding disorder, platelet-type, 8 10.7
8 platelet-type bleeding disorder 20 10.7
9 platelet glycoprotein iv deficiency 10.7
10 platelet-type bleeding disorder 12 10.7
11 thromboxane synthase deficiency 10.7
12 bleeding disorder, platelet-type, 19 10.7
13 bleeding disorder, platelet-type, 17 10.7
14 quebec platelet disorder 10.7
15 bleeding disorder, platelet-type, 18 10.7
16 scott syndrome 10.7
17 bleeding disorder, platelet-type, 15 10.7
18 glanzmann thrombasthenia 10.7
19 bleeding disorder, platelet-type, 16, autosomal dominant 10.7
20 bleeding disorder, platelet-type, 11 10.7
21 hemophilia b 10.7
22 vcl-related familial hypertrophic cardiomyopathy 10.4 F8 VWF
23 vcp-related amyotrophic lateral sclerosis/frontotemporal dementia 10.4 F8 VWF
24 influenza 10.4 F2 F3 SERPINC1
25 pancreatic ductal carcinoma 10.4 F2 F3 SERPINC1
26 prostatic hypertrophy 10.4 F2 F3 VWF
27 chorioretinal scar 10.4 F2 F3 SERPINC1
28 von willibrand disease, type 3 10.4 F7 VWF
29 mixed hepatoblastoma 10.4 F2 F3 SERPINC1
30 primary peritoneal carcinoma 10.4 F8 F9
31 dmd-related dilated cardiomyopathy 10.4 F2 F3 SERPINC1
32 secretory diarrhea myopathy and deafness 10.4 F3 SERPINC1 VWF
33 midline cystocele 10.4 F2 F3 SERPINC1
34 acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia 10.3 F3 F8 F9
35 high anorectal malformation 10.3 F8 VWF
36 urogenital adysplasia 10.3 THBD VWF
37 neuronopathy, distal hereditary motor, type iid 10.3 F3 F9 SERPINC1
38 dyskinetic cerebral palsy 10.3 F2 F3 F8
39 acrodysplasia scoliosis 10.3 F3 F8 F9
40 thunderclap headache 10.3 F2 ITGA2B ITGB3
41 neuroaxonal dystrophy 10.3 F2 F8 SERPINC1
42 intestinal disaccharidase deficiency 10.3 F2 F3 SERPINC1
43 seminoma 10.3 F2 F3 F7
44 headache 10.3 F8 VWF
45 trismus-pseudocamptodactyly syndrome 10.3 GP1BA VWF
46 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 10.3 ITGA2B ITGB3
47 autonomic neuropathy 10.3 F2 F8 F9
48 ischemic optic neuropathy 10.3 F2 SERPINC1 VWF
49 facial dysmorphism-anorexia-cachexia-eye and skin anomalies syndrome 10.3 GP1BA ITGA2B ITGB3
50 infiltrating ureter transitional cell carcinoma 10.3 F2 F7 F8

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 F9 GP1BA GP1BB GP9 ITGA2B ITGB3
2 homeostasis/metabolism MP:0005376 10.21 VWF ADAMTS13 CD40LG F2 F3 F7
3 cardiovascular system MP:0005385 10.1 CD40LG F2 F3 F7 F9 ITGA2B
4 embryo MP:0005380 9.97 F2 F3 F9 ITGA2B ITGB3 MPL
5 immune system MP:0005387 9.97 ADAMTS13 CD40LG F2 F3 F8 F9
6 mortality/aging MP:0010768 9.8 ADAMTS13 ATAT1 CD40LG F2 F3 F7
7 reproductive system MP:0005389 9.28 MTHFR SERPINC1 THBD ATAT1 CD40LG F2

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1121)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3 1197-18-8 5526
2
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9041-08-1
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 9005-49-6 772 46507594
4 Nadroparin Approved Phase 4,Phase 3,Phase 2 9041-08-1
5
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 179324-69-7 387447 93860
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
7
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
8
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
9
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 56420-45-2 41867
10
Zoledronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 118072-93-8 68740
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
12
Norethindrone Approved Phase 4,Phase 2 68-22-4 6230
13
Rivaroxaban Approved Phase 4,Phase 3,Phase 2,Phase 1 366789-02-8
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
15
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
16
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
17
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
18
Valsartan Approved, Investigational Phase 4,Phase 2,Phase 1 137862-53-4 60846
19
Polidocanol Approved Phase 4 9002-92-0
20
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
21
Bacitracin Approved, Vet_approved Phase 4,Phase 1 1405-87-4 439542 10909430
22
Tolvaptan Approved Phase 4 150683-30-0 216237
23
Warfarin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 81-81-2 6691 54678486
24
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3 122320-73-4 77999
25
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2 128270-60-0 16129704
26
Remifentanil Approved Phase 4 132875-61-7 60815
27
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
28
Zinc Approved Phase 4,Phase 2,Phase 1 7440-66-6 32051 23994
29
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
30
Lamivudine Approved, Investigational Phase 4,Phase 1,Phase 2 134678-17-4 60825
31
Ribavirin Approved Phase 4,Phase 2,Phase 1 36791-04-5 37542
32
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
33
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
35
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
36
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
37
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
38
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
39
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
40
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 148-82-3 4053 460612
41
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
42
Panobinostat Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 404950-80-7 6918837
43
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
44
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 1 33069-62-4 36314
45
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
46
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
47
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2 797-63-7, 17489-40-6 13109
48
Nitroglycerin Approved, Investigational Phase 4,Phase 1 55-63-0 4510
49
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
50
Tinzaparin Approved Phase 4,Phase 1,Phase 2 9005-49-6, 9041-08-1 25244225

Interventional clinical trials:

(show top 50) (show all 4626)
id Name Status NCT ID Phase
1 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4
2 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4
3 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4
4 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4
5 Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery Unknown status NCT01418521 Phase 4
6 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4
7 Pseudohyponatremia of Multiple Myeloma is True Hyponatremia Unknown status NCT01425606 Phase 4
8 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4
9 A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma Unknown status NCT01868828 Phase 4
10 Stage I Multiple Myeloma Treatment Unknown status NCT00733538 Phase 4
11 Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy Unknown status NCT02264743 Phase 4
12 Reversal of the Antithrombotic Action of New Oral Anticoagulants Unknown status NCT01478282 Phase 4
13 Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes Unknown status NCT01322711 Phase 4
14 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
15 Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Unknown status NCT00442429 Phase 4
16 Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome Unknown status NCT02341729 Phase 4
17 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4
18 Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel Unknown status NCT02032290 Phase 4
19 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
20 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4
21 An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst Unknown status NCT02154789 Phase 4
22 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4
23 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4
24 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4
25 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4
26 Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients Unknown status NCT02106962 Phase 4
27 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4
28 Ticagrelor and Clopidogrel on Reperfusion in Patients With AMI Unknown status NCT02233790 Phase 4
29 Hormones Inflammation and Thrombosis Unknown status NCT01875185 Phase 4
30 DEDICA (Dose of HEparin During Coronary Angioplasty) Trial Unknown status NCT01694459 Phase 4
31 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
32 Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With Ascites Unknown status NCT01552590 Phase 4
33 PCC and Fibrinogen Compared With FFP in PPH Unknown status NCT01910675 Phase 4
34 Hemodilution and Coagulopathy With 3 Colloids Completed NCT01727830 Phase 4
35 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4
36 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4
37 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
38 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
39 The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass Completed NCT01435304 Phase 4
40 Anticoagulant Clinics and Vitamin K Antagonists Completed NCT00966290 Phase 4
41 Conventional Versus Point-of-care Based Coagulation Management Completed NCT00997841 Phase 4
42 Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery Completed NCT00516126 Phase 4
43 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Completed NCT02009033 Phase 4
44 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD) Completed NCT00168090 Phase 4
45 BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) Completed NCT00586521 Phase 4
46 Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4
47 High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors Completed NCT00571584 Phase 4
48 Trial of NovoSeven® in Haemophilia - Joint Bleeds Completed NCT00108797 Phase 4
49 Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes Completed NCT00738023 Phase 4
50 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

Publications for Blood Coagulation Disease

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.78 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.13 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF
4
Show member pathways
12.1 F2 ITGB3 PF4 THBD
5 12.02 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF
6 12 F2 F3 F7 F8 F9 SERPINC1
7 11.96 GP1BA ITGA2B ITGB3 MPL THPO
8 11.87 GP1BA GP1BB GP9 ITGA2B ITGB3 THPO
9
Show member pathways
11.8 F2 GP1BA GP1BB GP9 ITGA2B ITGB3
10 11.67 F3 ITGB3 VWF
11
Show member pathways
11.61 F2 F3 F7 F8 F9 GP1BA
12 11.51 F2 GP1BB GP9 ITGA2B ITGB3 VWF
13 11.39 GP9 ITGA2B ITGB3
14 10.88 F2 F7 F9
15 10.85 GP1BA GP1BB GP9 VWF
16 10.67 GP1BA GP1BB GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.63 F2 F7 F9
2 endoplasmic reticulum lumen GO:0005788 9.63 ADAMTS13 F2 F7 F8 F9 SERPINC1
3 platelet alpha granule lumen GO:0031093 9.61 F8 PF4 VWF
4 cell surface GO:0009986 9.56 ADAMTS13 CD40LG F3 GP1BA ITGA2B ITGB3
5 platelet alpha granule membrane GO:0031092 9.48 ITGA2B ITGB3
6 extracellular space GO:0005615 9.36 ADAMTS13 CD40LG F2 F3 F7 F8
7 serine-type peptidase complex GO:1905286 9.32 F3 F7
8 plasma membrane GO:0005886 10.21 CD40LG F2 F3 F7 F8 F9
9 integral component of plasma membrane GO:0005887 10.01 CD40LG GP1BA GP1BB GP9 ITGA2B ITGB3
10 extracellular region GO:0005576 10 ADAMTS13 CD40LG F2 F3 F7 F8

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 9.93 ADAMTS13 F2 F3 F7 F8 F9
2 cell surface receptor signaling pathway GO:0007166 9.91 F2 GP1BA GP1BB MPL
3 ER to Golgi vesicle-mediated transport GO:0006888 9.85 F2 F7 F8 F9
4 cytokine-mediated signaling pathway GO:0019221 9.83 F3 GP1BA MPL PF4
5 cell-matrix adhesion GO:0007160 9.79 ADAMTS13 ITGA2B ITGB3
6 integrin-mediated signaling pathway GO:0007229 9.77 ADAMTS13 ITGA2B ITGB3
7 platelet degranulation GO:0002576 9.77 F8 ITGA2B ITGB3 PF4 VWF
8 positive regulation of protein kinase B signaling GO:0051897 9.76 F3 F7 THPO
9 protein processing GO:0016485 9.73 ADAMTS13 F3 F7
10 platelet aggregation GO:0070527 9.69 GP1BA ITGA2B ITGB3
11 platelet activation GO:0030168 9.65 ADAMTS13 CD40LG F2 F8 GP1BA GP1BB
12 regulation of blood coagulation GO:0030193 9.63 F2 GP1BA SERPINC1
13 cell-substrate adhesion GO:0031589 9.62 ITGB3 VWF
14 positive regulation of blood coagulation GO:0030194 9.61 F2 F7
15 signal peptide processing GO:0006465 9.61 F2 F7 F9
16 positive regulation of positive chemotaxis GO:0050927 9.59 F3 F7
17 negative regulation of fibrinolysis GO:0051918 9.58 F2 THBD
18 peptidyl-glutamic acid carboxylation GO:0017187 9.58 F2 F7 F9
19 negative regulation of platelet activation GO:0010544 9.57 F2 THBD
20 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
21 thrombopoietin-mediated signaling pathway GO:0038163 9.49 MPL THPO
22 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.48 F3 F7
23 blood coagulation, intrinsic pathway GO:0007597 9.17 F2 F8 F9 GP1BA GP1BB GP9
24 blood coagulation GO:0007596 10.07 ADAMTS13 F2 F3 F7 F8 F9
25 cell adhesion GO:0007155 10.01 GP1BA GP1BB GP9 ITGA2B ITGB3 VWF

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.35 F2 F3 F7 F8 F9
2 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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