MCID: BLD051
MIFTS: 43

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 14
Blood Coagulation Disorders 42 69
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD10 33 D68.9 O72.3
ICD9CM 35 286
MeSH 42 D001778
NCIt 47 C2902
UMLS 69 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and bleeding disorder, platelet-type, 16, autosomal dominant. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Estradiol and Norethindrone have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
id Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 34.4 F2 F3 F8
2 bleeding disorder, platelet-type, 16, autosomal dominant 30.4 F2 F3 F8 F9 GP1BA GP9
3 ubqln2-related amyotrophic lateral sclerosis/frontotemporal dementia 10.9 F8 VWF
4 uchl1-related parkinson disease susceptibility 10.9 F8 VWF
5 unna-thost palmoplantar keratoderma 10.9 THBD VWF
6 intermediate anorectal malformation 10.9 F8 F9
7 von willebrand disease, type 1 10.9 F7 VWF
8 mild hemophilia b 10.9 F8 VWF
9 pyridoxine deficiency anemia 10.9 F2 F3 SERPINC1
10 myiasis 10.9 F2 F3 SERPINC1
11 testicular gonadoblastoma 10.9 F2 F3 SERPINC1
12 rectum neuroendocrine neoplasm 10.9 F2 F3 SERPINC1
13 chronic diarrhea due to guanylate cyclase 2c overactivity 10.9 F3 SERPINC1 VWF
14 floppy infant syndrome 10.9 F8 VWF
15 midline cystocele 10.9 F2 F3 SERPINC1
16 lethal congenital contracture syndrome 10.9 F2 F3 SERPINC1
17 congenital syphilis 10.9 F2 F3 SERPINC1
18 hyperthyroidism 10.8 F2 F3
19 angioedema, hereditary, type iii 10.8 F3 F9 SERPINC1
20 inflammatory bowel disease 18 10.8 MPL THPO
21 acquired von willebrand syndrome 10.8 F3 F8 F9
22 childhood brain stem glioma 10.8 F2 SERPINC1 THPO
23 female breast cancer 10.8 F2 F3 F8
24 acquired pure red cell aplasia 10.8 F3 F8 F9
25 neuroaxonal dystrophy 10.8 F2 F8 SERPINC1
26 ischemic heart disease 10.8 F2 SERPINC1 VWF
27 atrial fibrillation, familial, 18 10.8 ITGA2B ITGB3
28 autonomic neuropathy 10.8 F2 F8 F9
29 central nervous system germ cell tumor 10.8 F2 F3 F7
30 hemolytic-uremic syndrome 10.8 F2 F3 SERPINC1
31 sagittal sinus thrombosis 10.8 F3 SERPINC1
32 alpha-2-plasmin inhibitor deficiency 10.8 GP1BA VWF
33 hypotrichosis, congenital, with juvenile macular dystrophy 10.8 MPL THPO
34 moderately severe hemophilia b 10.8 F2 F3 F8
35 hereditary amyloidosis 10.8 CD40LG F3 SERPINC1
36 syncope 10.8 F2 MTHFR SERPINC1
37 psychologic dyspareunia 10.7 F2 THBD VWF
38 follicular adenoma 10.7 F2 MTHFR SERPINC1
39 alopecia-mental retardation syndrome 1 10.7 MPL THPO
40 46,xy ovotesticular disorder of sex development 10.7 F2 F3
41 diphyllobothriasis 10.7 CD40LG SERPINC1
42 dyskeratosis congenita autosomal recessive 10.7 F2 SERPINC1 THBD
43 hiv-1 10.7 F2 MTHFR SERPINC1
44 vaginal yolk sac tumor 10.7 F7 F9 ITGA2B
45 thrombocytopenia, congenital amegakaryocytic 10.7 MPL THPO
46 von willibrand disease, type 3 10.7 F2 F3 F8 VWF
47 cryptosporidiosis 10.7 F2 MTHFR SERPINC1
48 hydrarthrosis 10.7 F7 F9 ITGA2B
49 angular blepharoconjunctivitis 10.7 F2 MTHFR SERPINC1
50 van maldergem syndrome 2 10.7 F2 F3 F8 VWF

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 SERPINC1 THBD THPO VWF ADAMTS13 ATAT1
2 homeostasis/metabolism MP:0005376 10.21 ADAMTS13 CD40LG F2 F3 F7 F8
3 cardiovascular system MP:0005385 10.1 F3 F7 F9 ITGA2B ITGB3 SERPINC1
4 embryo MP:0005380 9.97 F2 F3 F9 ITGA2B ITGB3 MPL
5 immune system MP:0005387 9.97 ADAMTS13 CD40LG F2 F3 F8 F9
6 mortality/aging MP:0010768 9.83 F8 F9 ITGB3 MPL MTHFR SERPINC1
7 reproductive system MP:0005389 9.28 ATAT1 CD40LG F2 F8 ITGA2B ITGB3

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 737)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Norethindrone Approved Phase 4 68-22-4 6230
3
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
4
Thrombin Approved Phase 4,Phase 3,Phase 2,Phase 1
5
Rivaroxaban Approved Phase 4,Phase 3,Phase 2,Phase 1 366789-02-8
6
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 9005-49-6 772 46507594
7
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
8
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
9
Metformin Approved Phase 4 657-24-9 14219 4091
10
Valsartan Approved, Investigational Phase 4,Phase 2,Phase 1 137862-53-4 60846
11
Polidocanol Approved Phase 4 9002-92-0
12
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
13
Warfarin Approved Phase 4,Phase 2,Phase 3,Phase 1 81-81-2 6691 54678486
14
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3 1197-18-8 5526
15
Dalteparin Approved Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6
16
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
17
Paclitaxel Approved, Vet_approved Phase 4,Phase 2 33069-62-4 36314
18
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
19
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2 128270-60-0 16129704
20
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
21
Nitroglycerin Approved, Investigational Phase 4,Phase 1 55-63-0 4510
22
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
23 Nadroparin Approved Phase 4,Phase 3,Phase 2 9041-08-1
24
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 53-03-2 5865
25
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
26
Protein C Approved Phase 4,Phase 3,Phase 1,Phase 2
27
Sucralfate Approved Phase 4 54182-58-0
28
Acenocoumarol Approved Phase 4 152-72-7 9052 54676537
29
Phenindione Approved Phase 4 83-12-5 4760
30
Phenprocoumon Approved Phase 4 435-97-2 9908 54680692
31
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
32
Ethanol Approved Phase 4,Phase 1,Early Phase 1 64-17-5 702
33
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
34
Povidone Approved Phase 4 9003-39-8
35
Abciximab Approved Phase 4,Phase 2 143653-53-6
36
Eszopiclone Approved Phase 4 138729-47-2 969472
37
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
38
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
39
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 124-94-7 31307
40
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
41
Pravastatin Approved Phase 4,Phase 1,Phase 2 81093-37-0 54687
42
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
43
Interferon beta-1a Approved, Investigational Phase 4,Phase 3 145258-61-3 6438354
44
Interferon beta-1b Approved Phase 4,Phase 3 145155-23-3
45
Dipyridamole Approved Phase 4 58-32-2 3108
46
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
47
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
48
Apixaban Approved Phase 4,Phase 3,Phase 1 503612-47-3 10182969
49
Atenolol Approved Phase 4 29122-68-7 2249
50
Tinzaparin Approved Phase 4,Phase 2 9005-49-6, 9041-08-1 25244225

Interventional clinical trials:

(show top 50) (show all 1577)

id Name Status NCT ID Phase Drugs
1 Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy Unknown status NCT02264743 Phase 4 Femoston Conti;EVOREL® CONTI
2 Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes Unknown status NCT01322711 Phase 4 Atorvastatin;Placebo
3 Reversal of the Antithrombotic Action of New Oral Anticoagulants Unknown status NCT01478282 Phase 4 Rivaroxaban;Dabigatran
4 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
5 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4 Human Plasma
6 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
7 Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Unknown status NCT00442429 Phase 4
8 Rivaroxaban for Antiphospholipid Antibody Syndrome Unknown status NCT02116036 Phase 4 Rivaroxaban
9 Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel Unknown status NCT02032290 Phase 4 ticagrelor loading;Clopidogrel loading
10 Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome Unknown status NCT02341729 Phase 4 ticagrelor
11 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
12 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
13 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4 Aliskiren + Valsartan
14 An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst Unknown status NCT02154789 Phase 4 polidocanol
15 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
16 Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery Unknown status NCT01201070 Phase 4 antithrombin III
17 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
18 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
19 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD) Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
20 The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass Completed NCT01435304 Phase 4
21 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
22 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Completed NCT02009033 Phase 4 Lactated Ringer;Hydroxyethylstarch
23 The Effect of 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Coagulation in Patients Medicated With Antiplatelet Agents Prior to Off-Pump Coronary Bypass Graft Surgery Completed NCT01051206 Phase 4 6% hydroxyethyl Stach 130/0.4
24 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4 Human fibrinogen concentrate
25 Anticoagulant Clinics and Vitamin K Antagonists Completed NCT00966290 Phase 4 Anticoagulant (warfarin, acenocoumarol, fluindione);Anticoagulant (warfarin, acenocoumarol, fluindione)
26 Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery Completed NCT00516126 Phase 4
27 The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study Completed NCT01067638 Phase 4 Tranexamic Acid
28 Understanding the Increased Risk of Cardiovascular Disease in People With HIV Completed NCT00577681 Phase 4 Antiretroviral Therapy (ART)
29 Effects of Ulinastatin on Coagulation in High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft Surgery Completed NCT01084044 Phase 4 ulinastatin, saline solution
30 BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) Completed NCT00586521 Phase 4 Kogenate (BAY14-2222)
31 Platelet-dependent Thrombosis: a Placebo-controlled Trial of Antiplatelet Therapy (Clopidogrel) Completed NCT00728156 Phase 4 clopidogrel;placebo
32 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
33 Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia Completed NCT00230659 Phase 4
34 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
35 Comparison of Heparin Types; Efficacy and Safety Completed NCT01343381 Phase 4 Hepalean Heparin;PPC Heparin
36 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
37 Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal Completed NCT01159210 Phase 4
38 Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery Completed NCT01174719 Phase 4 volume replacement;Humanalbumin 5%;volume replacement
39 Benefit of Elevation of HDL-C on Cardiovascular Outcomes in Women Completed NCT00590629 Phase 4 Niaspan
40 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
41 Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
42 The Use of Low Molecular Weight Heparin in Hemodiafiltration Completed NCT00756145 Phase 4
43 Antithrombotic Triple Therapy in Humans Completed NCT01812200 Phase 4 Dabigatran, Ticagrelor, ASA;Rivaroxaban, Ticagrelor, ASA;Phenprocoumon, Ticagrelor, ASA
44 The Dual Antiplatelet Therapy Study (DAPT Study) Completed NCT00977938 Phase 4 Placebo & Aspirin;Clopidogrel & Aspirin, Prasugrel & Aspirin
45 Dose-finding of Rivaroxaban in Hemodialysis Completed NCT02047006 Phase 4 Rivaroxaban 10 mg
46 The Effect of Morphine on Prasugrel Absorption in STEMI Patients Completed NCT01536964 Phase 4 morphine;saline
47 Study to Assess Clearances and Bio-compatibility of ELISIO Dialyzer Completed NCT01042327 Phase 4
48 Hemodilution and Coagulopathy With 3 Colloids Completed NCT01727830 Phase 4
49 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
50 Comparison of Autologous Serum Versus Preservative Free Artificial Tear Completed NCT02752763 Phase 4 %40 diluted Autologous serum;Preservative free artificial tears(Tears naturale free, Refresh single dose eye drop)

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

MalaCards organs/tissues related to Blood Coagulation Disease:

39
Liver, Heart, Testes, Endothelial, Lung, Breast, Brain

Publications for Blood Coagulation Disease

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.76 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.1 F2 ITGB3 PF4 THBD
4
Show member pathways
12.05 GP1BA GP9 ITGA2B ITGB3 VWF
5 12 F2 F3 F7 F8 F9 SERPINC1
6 11.92 GP1BA GP9 ITGA2B ITGB3 VWF
7 11.87 GP1BA ITGA2B ITGB3 MPL THPO
8 11.75 GP1BA GP9 ITGA2B ITGB3 THPO
9
Show member pathways
11.75 F2 GP1BA GP9 ITGA2B ITGB3 MPL
10 11.67 F3 ITGB3 VWF
11
Show member pathways
11.57 F2 F3 F7 F8 F9 GP1BA
12 11.43 F2 GP9 ITGA2B ITGB3 VWF
13 11.39 GP9 ITGA2B ITGB3
14 10.88 F2 F7 F9
15 10.8 GP1BA GP9 VWF
16 10.63 GP1BA GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADAMTS13 CD40LG F2 F3 F7 F8
2 endoplasmic reticulum lumen GO:0005788 9.63 ADAMTS13 F2 F7 F8 F9 SERPINC1
3 Golgi lumen GO:0005796 9.61 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.58 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.46 ITGA2B ITGB3
6 serine-type peptidase complex GO:1905286 9.32 F3 F7
7 cell surface GO:0009986 9.23 ADAMTS13 CD40LG F3 GP1BA ITGA2B ITGB3
8 plasma membrane GO:0005886 10.18 CD40LG F2 F3 F7 F8 F9
9 extracellular region GO:0005576 10 ADAMTS13 CD40LG F2 F3 F7 F8

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.84 F2 F7 F8 F9
2 cytokine-mediated signaling pathway GO:0019221 9.83 F3 GP1BA MPL PF4
3 platelet activation GO:0030168 9.81 ADAMTS13 CD40LG F2 F8 GP1BA GP9
4 cell-matrix adhesion GO:0007160 9.78 ADAMTS13 ITGA2B ITGB3
5 integrin-mediated signaling pathway GO:0007229 9.77 ADAMTS13 ITGA2B ITGB3
6 positive regulation of protein kinase B signaling GO:0051897 9.77 F3 F7 THPO
7 platelet degranulation GO:0002576 9.77 F8 ITGA2B ITGB3 PF4 VWF
8 blood coagulation, intrinsic pathway GO:0007597 9.73 F2 F8 F9 GP1BA GP9 VWF
9 blood coagulation GO:0007596 9.73 ADAMTS13 F2 F3 F7 F8 F9
10 protein processing GO:0016485 9.72 ADAMTS13 F3 F7
11 platelet aggregation GO:0070527 9.69 GP1BA ITGA2B ITGB3
12 regulation of blood coagulation GO:0030193 9.63 F2 GP1BA SERPINC1
13 cell-substrate adhesion GO:0031589 9.61 ITGB3 VWF
14 signal peptide processing GO:0006465 9.61 F2 F7 F9
15 positive regulation of blood coagulation GO:0030194 9.58 F2 F7
16 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
17 peptidyl-glutamic acid carboxylation GO:0017187 9.58 F2 F7 F9
18 negative regulation of fibrinolysis GO:0051918 9.57 F2 THBD
19 negative regulation of platelet activation GO:0010544 9.56 F2 THBD
20 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
21 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.49 F3 F7
22 thrombopoietin-mediated signaling pathway GO:0038163 9.48 MPL THPO
23 hemostasis GO:0007599 9.36 ADAMTS13 F2 F3 F7 F8 F9

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.26 F2 F3 F7 F9
2 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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