MCID: BLD051
MIFTS: 38

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 14
Blood Coagulation Disorders 72 41 69
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD10 32 D68.9 O72.3
ICD9CM 34 286
MeSH 41 D001778
NCIt 46 C2902
UMLS 69 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and pseudo-von willebrand disease. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Coagulopathy (also called a bleeding disorder) is a condition in which the blood’s ability to coagulate... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 32.4 F2 F3 F7 F8 F9 GP1BA
2 pseudo-von willebrand disease 31.9 GP1BA VWF
3 antithrombin iii deficiency 31.9 F2 MTHFR SERPINC1
4 bleeding disorder, platelet-type, 16 31.8 ITGA2B ITGB3
5 gray platelet syndrome 31.7 CD40LG GP9 VWF
6 hemophilia b 31.5 F2 F3 F7 F8 F9 SERPINC1
7 bernard-soulier syndrome 30.8 F2 F8 GP1BA GP9 ITGA2B ITGB3
8 glanzmann thrombasthenia 30.7 F2 F3 F8 F9 GP1BA GP9
9 bleeding disorder, platelet-type, 17 10.8
10 scott syndrome 10.8
11 quebec platelet disorder 10.8
12 bleeding disorder, platelet-type, 12 10.8
13 platelet glycoprotein iv deficiency 10.8
14 bleeding disorder, platelet-type, 8 10.8
15 bleeding disorder, platelet-type, 14 10.8
16 bleeding disorder, platelet-type, 9 10.8
17 bleeding disorder, platelet-type, 11 10.8
18 bleeding disorder, platelet-type, 15 10.8
19 bleeding disorder, platelet-type, 18 10.8
20 bleeding disorder, platelet-type, 19 10.8
21 bleeding disorder, platelet-type, 20 10.8
22 mild hemophilia a 10.6 F8 VWF
23 severe hemophilia b 10.6 F8 F9
24 intestinal impaction 10.6 F2 F3 SERPINC1
25 unilateral absence of a pulmonary artery 10.6 THBD VWF
26 fainting 10.6 F8 VWF
27 leech infestation 10.6 F2 F3 SERPINC1
28 giant hemangioma 10.6 F2 F3 SERPINC1
29 sagittal sinus thrombosis 10.6 F2 F3 SERPINC1
30 angina pectoris 10.6 F3 SERPINC1 VWF
31 blue toe syndrome 10.6 F2 F3 SERPINC1
32 intracranial embolism 10.6 F2 F3 SERPINC1
33 purpura fulminans 10.6 F2 F3 SERPINC1
34 cerebral falx meningioma 10.6 F2 F3
35 peripheral vertigo 10.6 F2 F3 SERPINC1
36 factor xii deficiency 10.6 F3 F9 SERPINC1
37 factor viii deficiency 10.6 F2 F8 VWF
38 thrombocytopenia 3 10.6 MPL THPO
39 acquired hemophilia a 10.6 F3 F8 F9
40 hypersplenism 10.6 F2 SERPINC1 THPO
41 acquired hemophilia 10.6 F3 F8 F9
42 intermittent claudication 10.5 F2 SERPINC1 VWF
43 post-thrombotic syndrome 10.5 F2 F8 SERPINC1
44 von willebrand disease, type 2 10.5 F7 F8 VWF
45 bombay phenotype 10.5 ADAMTS13 VWF
46 anterior cranial fossa meningioma 10.5 F2 F3 F7
47 cardiac tamponade 10.5 F2 F8 F9
48 intracranial sinus thrombosis 10.5 F3 SERPINC1
49 intermediate coronary syndrome 10.5 F3 ITGA2B SERPINC1
50 hepatitis a 10.5 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 PF4 SERPINC1 THBD THPO VWF MPL
2 homeostasis/metabolism MP:0005376 10.21 WDTC1 MTHFR PF4 SERPINC1 THBD THPO
3 cardiovascular system MP:0005385 10.1 VWF SERPINC1 THBD F7 F9 CD40LG
4 embryo MP:0005380 9.97 MPL SERPINC1 THBD ITGB3 F9 F2
5 immune system MP:0005387 9.97 MPL SERPINC1 THBD THPO VWF ADAMTS13
6 mortality/aging MP:0010768 9.83 WDTC1 MTHFR SERPINC1 THBD VWF MPL
7 reproductive system MP:0005389 9.28 MTHFR SERPINC1 THBD ITGB3 F8 ATAT1

Drugs & Therapeutics for Blood Coagulation Disease

Search Clinical Trials , NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

# Title Authors Year
1
[Blood coagulation disorders observed in arteriosclerosis obliterans]. ( 8808808 )
1996
2
[A newly discovered blood coagulation disorder. Resistance to activated protein C as a cause of thrombosis]. ( 8289554 )
1994
3
Hemorrhagic thrombocythemia; a blood coagulation disorder. ( 13354035 )
1956

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.76 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.1 F2 ITGB3 PF4 THBD
4
Show member pathways
12.05 GP1BA GP9 ITGA2B ITGB3 VWF
5 12 F2 F3 F7 F8 F9 SERPINC1
6 11.92 GP1BA GP9 ITGA2B ITGB3 VWF
7 11.87 GP1BA ITGA2B ITGB3 MPL THPO
8
Show member pathways
11.79 F2 F7 F9
9 11.75 GP1BA GP9 ITGA2B ITGB3 THPO
10
Show member pathways
11.75 F2 GP1BA GP9 ITGA2B ITGB3 MPL
11 11.68 F3 ITGB3 VWF
12
Show member pathways
11.57 F2 F3 F7 F8 F9 GP1BA
13 11.43 F2 GP9 ITGA2B ITGB3 VWF
14 11.39 GP9 ITGA2B ITGB3
15 10.88 F2 F7 F9
16 10.87 CD40LG ITGA2B ITGB3 PF4 THPO
17 10.8 GP1BA GP9 VWF
18 10.63 GP1BA GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADAMTS13 CD40LG F2 F3 F7 F8
2 endoplasmic reticulum lumen GO:0005788 9.63 ADAMTS13 F2 F7 F8 F9 SERPINC1
3 Golgi lumen GO:0005796 9.61 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.58 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.46 ITGA2B ITGB3
6 serine-type peptidase complex GO:1905286 9.32 F3 F7
7 cell surface GO:0009986 9.23 ADAMTS13 CD40LG F3 GP1BA ITGA2B ITGB3
8 plasma membrane GO:0005886 10.18 CD40LG F2 F3 F7 F8 F9
9 extracellular region GO:0005576 10 ADAMTS13 CD40LG F2 F3 F7 F8

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F2 F7 F8 F9
2 cytokine-mediated signaling pathway GO:0019221 9.81 F3 GP1BA MPL PF4
3 platelet activation GO:0030168 9.81 ADAMTS13 CD40LG F2 F8 GP1BA GP9
4 cell-matrix adhesion GO:0007160 9.77 ADAMTS13 ITGA2B ITGB3
5 integrin-mediated signaling pathway GO:0007229 9.77 ADAMTS13 ITGA2B ITGB3
6 platelet degranulation GO:0002576 9.77 F8 ITGA2B ITGB3 PF4 VWF
7 blood coagulation, intrinsic pathway GO:0007597 9.73 F2 F8 F9 GP1BA GP9 VWF
8 blood coagulation GO:0007596 9.73 ADAMTS13 F2 F3 F7 F8 F9
9 regulation of megakaryocyte differentiation GO:0045652 9.72 GP1BA ITGA2B PF4
10 protein processing GO:0016485 9.71 ADAMTS13 F3 F7
11 regulation of blood coagulation GO:0030193 9.63 F2 GP1BA SERPINC1
12 cell-substrate adhesion GO:0031589 9.61 ITGB3 VWF
13 signal peptide processing GO:0006465 9.61 F2 F7 F9
14 positive regulation of blood coagulation GO:0030194 9.58 F2 F7
15 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
16 peptidyl-glutamic acid carboxylation GO:0017187 9.58 F2 F7 F9
17 negative regulation of fibrinolysis GO:0051918 9.57 F2 THBD
18 negative regulation of platelet activation GO:0010544 9.56 F2 THBD
19 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
20 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.49 F3 F7
21 thrombopoietin-mediated signaling pathway GO:0038163 9.48 MPL THPO
22 hemostasis GO:0007599 9.36 ADAMTS13 F2 F3 F7 F8 F9

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ADAMTS13 CD40LG F2 F3 F7 F8
2 serine-type endopeptidase activity GO:0004252 9.46 F2 F3 F7 F9
3 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....