MCID: BLD051
MIFTS: 38

Blood Coagulation Disease

Categories: Blood diseases

Aliases & Classifications for Blood Coagulation Disease

MalaCards integrated aliases for Blood Coagulation Disease:

Name: Blood Coagulation Disease 12 14
Blood Coagulation Disorders 72 41 69
Postpartum Coagulation Defect with Delivery 12
Postpartum Coagulation Defect 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1247
ICD10 32 D68.9 O72.3
ICD9CM 34 286
MeSH 41 D001778
NCIt 46 C2902
UMLS 69 C0005779

Summaries for Blood Coagulation Disease

MalaCards based summary : Blood Coagulation Disease, also known as blood coagulation disorders, is related to inherited blood coagulation disease and pseudo-von willebrand disease. An important gene associated with Blood Coagulation Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Dalteparin have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Coagulopathy (also called a bleeding disorder) is a condition in which the blood’s ability to coagulate... more...

Related Diseases for Blood Coagulation Disease

Diseases in the Blood Coagulation Disease family:

Inherited Blood Coagulation Disease

Diseases related to Blood Coagulation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 inherited blood coagulation disease 32.4 F2 F3 F7 F8 F9 GP1BA
2 pseudo-von willebrand disease 31.9 GP1BA VWF
3 antithrombin iii deficiency 31.9 F2 MTHFR SERPINC1
4 bleeding disorder, platelet-type, 16 31.8 ITGA2B ITGB3
5 gray platelet syndrome 31.7 CD40LG GP9 VWF
6 hemophilia b 31.5 F2 F3 F7 F8 F9 SERPINC1
7 bernard-soulier syndrome 30.8 F2 F8 GP1BA GP9 ITGA2B ITGB3
8 glanzmann thrombasthenia 30.7 F2 F3 F8 F9 GP1BA GP9
9 bleeding disorder, platelet-type, 17 10.8
10 scott syndrome 10.8
11 quebec platelet disorder 10.8
12 bleeding disorder, platelet-type, 12 10.8
13 platelet glycoprotein iv deficiency 10.8
14 bleeding disorder, platelet-type, 8 10.8
15 bleeding disorder, platelet-type, 14 10.8
16 bleeding disorder, platelet-type, 9 10.8
17 bleeding disorder, platelet-type, 11 10.8
18 bleeding disorder, platelet-type, 15 10.8
19 bleeding disorder, platelet-type, 18 10.8
20 bleeding disorder, platelet-type, 19 10.8
21 bleeding disorder, platelet-type, 20 10.8
22 mild hemophilia a 10.6 F8 VWF
23 severe hemophilia b 10.6 F8 F9
24 intestinal impaction 10.6 F2 F3 SERPINC1
25 unilateral absence of a pulmonary artery 10.6 THBD VWF
26 fainting 10.6 F8 VWF
27 leech infestation 10.6 F2 F3 SERPINC1
28 giant hemangioma 10.6 F2 F3 SERPINC1
29 sagittal sinus thrombosis 10.6 F2 F3 SERPINC1
30 angina pectoris 10.6 F3 SERPINC1 VWF
31 blue toe syndrome 10.6 F2 F3 SERPINC1
32 intracranial embolism 10.6 F2 F3 SERPINC1
33 purpura fulminans 10.6 F2 F3 SERPINC1
34 cerebral falx meningioma 10.6 F2 F3
35 peripheral vertigo 10.6 F2 F3 SERPINC1
36 factor xii deficiency 10.6 F3 F9 SERPINC1
37 factor viii deficiency 10.6 F2 F8 VWF
38 thrombocytopenia 3 10.6 MPL THPO
39 acquired hemophilia a 10.6 F3 F8 F9
40 hypersplenism 10.6 F2 SERPINC1 THPO
41 acquired hemophilia 10.6 F3 F8 F9
42 intermittent claudication 10.5 F2 SERPINC1 VWF
43 post-thrombotic syndrome 10.5 F2 F8 SERPINC1
44 von willebrand disease, type 2 10.5 F7 F8 VWF
45 bombay phenotype 10.5 ADAMTS13 VWF
46 anterior cranial fossa meningioma 10.5 F2 F3 F7
47 cardiac tamponade 10.5 F2 F8 F9
48 intracranial sinus thrombosis 10.5 F3 SERPINC1
49 intermediate coronary syndrome 10.5 F3 ITGA2B SERPINC1
50 hepatitis a 10.5 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Blood Coagulation Disease:



Diseases related to Blood Coagulation Disease

Symptoms & Phenotypes for Blood Coagulation Disease

MGI Mouse Phenotypes related to Blood Coagulation Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 PF4 SERPINC1 THBD THPO VWF MPL
2 homeostasis/metabolism MP:0005376 10.21 WDTC1 MTHFR PF4 SERPINC1 THBD THPO
3 cardiovascular system MP:0005385 10.1 VWF SERPINC1 THBD F2 ITGA2B F3
4 embryo MP:0005380 9.97 MPL SERPINC1 THBD F2 ITGA2B F3
5 immune system MP:0005387 9.97 VWF MPL SERPINC1 THBD THPO F2
6 mortality/aging MP:0010768 9.83 MPL WDTC1 MTHFR SERPINC1 THBD VWF
7 reproductive system MP:0005389 9.28 MTHFR SERPINC1 THBD F2 ITGA2B ITGB3

Drugs & Therapeutics for Blood Coagulation Disease

Drugs for Blood Coagulation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 930)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 2,Phase 3,Not Applicable 1197-18-8 5526
2
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 46507594 772
4 Nadroparin Approved, Investigational Phase 4,Not Applicable 9041-08-1
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
6
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 179324-69-7 387447 93860
7
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
8
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
9
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
10
Zoledronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118072-93-8 68740
11
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 54678486 6691
12
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
13
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
14
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
16
Zinc Approved, Investigational Phase 4,Phase 2,Phase 1 7440-66-6 32051 23994
17
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
18
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
19
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 104987-11-3 445643 439492
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
22
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
23
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613 2171
25
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 81103-11-9 84029
26
Dexlansoprazole Approved, Investigational Phase 4,Phase 2 138530-94-6, 103577-45-3 9578005
27
Lansoprazole Approved, Investigational Phase 4,Phase 2 103577-45-3 3883
28
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 148-82-3 460612 4053
29
Lenalidomide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 191732-72-6 216326
30
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
31
Apixaban Approved Phase 4,Phase 3,Phase 2,Not Applicable 503612-47-3 10182969
32
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4 6253
33
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
34
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
35
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
36
Hydroxychloroquine Approved Phase 4,Phase 1,Phase 2 118-42-3 3652
37
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
38
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
39
Acenocoumarol Approved, Investigational Phase 4,Not Applicable 152-72-7 54676537 9052
40 fluindione Approved, Investigational Phase 4 957-56-2
41
Phenindione Approved, Investigational Phase 4 83-12-5 4760
42
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
43
Progesterone Approved, Vet_approved Phase 4,Not Applicable 57-83-0 5994
44
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
45
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
46
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
47
Insulin Glargine Approved Phase 4 160337-95-1
48
Insulin Lispro Approved Phase 4 133107-64-9
49
Metformin Approved Phase 4,Phase 2,Phase 1 657-24-9 4091 14219
50
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754

Interventional clinical trials:

(show top 50) (show all 3860)

# Name Status NCT ID Phase Drugs
1 Trial of HoLEP vs. PVP in Treating BPH in Patients With Bleeding Tendency Unknown status NCT02293759 Phase 4
2 The Effect of Human Albumin on Coagulation Competence and Hemorrhage Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
3 Study Using Plasma for Patients Requiring Emergency Surgery Unknown status NCT01221389 Phase 4 Human Plasma
4 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
5 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
6 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
7 Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery Unknown status NCT01418521 Phase 4 Balanced hydroxyethyl starch solution;Ringer- albumin
8 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
9 Caffeic Acid Combining High-dose Dexamethasone in Management of ITP Unknown status NCT02556814 Phase 4 Caffeic acid tablets;Dexamethasone;placebo
10 A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma Unknown status NCT01868828 Phase 4 PAD;VCD
11 Pseudohyponatremia of Multiple Myeloma is True Hyponatremia Unknown status NCT01425606 Phase 4
12 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4 Bortezomib,Pirarubicin,Dexamethasone;Thalidomide,Pirarubicin,Dexamethasone
13 Stage I Multiple Myeloma Treatment Unknown status NCT00733538 Phase 4 zometa
14 Hemodilution and Coagulopathy With 3 Colloids Completed NCT01727830 Phase 4
15 Fibrinogen for Treatment of Pediatric Dilutional Coagulopathy. FibPaed Study. Completed NCT01487837 Phase 4 Human fibrinogen concentrate
16 The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders Completed NCT00904709 Phase 4 tranexamic acid
17 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
18 Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding Completed NCT00188747 Phase 4
19 Conventional Versus Point-of-care Based Coagulation Management Completed NCT00997841 Phase 4
20 The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass Completed NCT01435304 Phase 4
21 Anticoagulant Clinics and Vitamin K Antagonists Completed NCT00966290 Phase 4 Anticoagulant (warfarin, acenocoumarol, fluindione);Anticoagulant (warfarin, acenocoumarol, fluindione)
22 Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery Completed NCT00516126 Phase 4
23 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Completed NCT02009033 Phase 4 Lactated Ringer;Hydroxyethylstarch
24 Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD) Completed NCT00168090 Phase 4 Blood coagulation Factor VIII and vWF, human
25 BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) Completed NCT00586521 Phase 4 Kogenate (BAY14-2222)
26 Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery Completed NCT01561391 Phase 4 activated recombinant human factor VII;activated recombinant human factor VII;factor VIII
27 High Dose of Activated Recombinant Human Factor VII for Treatment of Mild/Moderate Joint Bleeds in Haemophilia Patients With Inhibitors Completed NCT00571584 Phase 4 activated recombinant human factor VII
28 Trial of NovoSeven® in Haemophilia - Joint Bleeds Completed NCT00108797 Phase 4 eptacog alfa (activated);Feiba VH
29 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
30 Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes Completed NCT00738023 Phase 4 Rosiglitazone;Normal saline 0.9%;Intralipid 20%
31 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
32 Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
33 Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty Completed NCT01815918 Phase 4 Hydrocortisone;Placebo
34 Antithrombotic Regimens and Outcome Completed NCT00448461 Phase 4 heparin;bivalirudin
35 Opioid-induced Hyperalgesia After Remifentanil Infusion Completed NCT01702389 Phase 4 Remifentanil
36 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
37 Exploratory Phase II Study of INC424 Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
38 Survey of Inhibitors in Plasma-Product Exposed Toddlers Completed NCT01064284 Phase 4 PLASMA DERIVED Factor VIII;Recombinant FVIII
39 Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery Completed NCT00357656 Phase 4 Recombinant Protein-Free Factor VIII (rAHF-PFM);Recombinant Protein-Free Factor VIII (rAHF-PFM)
40 Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A Completed NCT00289536 Phase 4
41 IMMUNINE Pre-Treatment Study Completed NCT01128881 Phase 4
42 Early Whole Blood in Patients Requiring Transfusion After Major Trauma Completed NCT01227005 Phase 4
43 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
44 Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes Completed NCT00191464 Phase 4 premeal insulin lispro mixtures;insulin glargine;metformin
45 Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patients Completed NCT02727647 Phase 4 FVIII;FVIII
46 Efficacy and Cost Effectiveness of Pharmacokinetic Dosing in Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
47 PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Hemophilia A Completed NCT02492984 Phase 4 Intravenous infusions of Xyntha
48 China ADVATE PTP Study Completed NCT02170402 Phase 4
49 Prophylaxis Versus on Demand Treatment for Children With Hemophilia A Completed NCT01810666 Phase 4
50 Canadian Hemophilia Prophylaxis Study Completed NCT01085344 Phase 4

Search NIH Clinical Center for Blood Coagulation Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: blood coagulation disorders

Genetic Tests for Blood Coagulation Disease

Anatomical Context for Blood Coagulation Disease

Publications for Blood Coagulation Disease

Articles related to Blood Coagulation Disease:

# Title Authors Year
1
[Blood coagulation disorders observed in arteriosclerosis obliterans]. ( 8808808 )
1996
2
[A newly discovered blood coagulation disorder. Resistance to activated protein C as a cause of thrombosis]. ( 8289554 )
1994
3
Hemorrhagic thrombocythemia; a blood coagulation disorder. ( 13354035 )
1956

Variations for Blood Coagulation Disease

Expression for Blood Coagulation Disease

Search GEO for disease gene expression data for Blood Coagulation Disease.

Pathways for Blood Coagulation Disease

Pathways related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 F2 F3 F7 F8 F9 GP1BA
2
Show member pathways
12.76 F2 F3 F7 F8 F9 SERPINC1
3
Show member pathways
12.1 F2 ITGB3 PF4 THBD
4
Show member pathways
12.05 GP1BA GP9 ITGA2B ITGB3 VWF
5 12 F2 F3 F7 F8 F9 SERPINC1
6 11.92 GP1BA GP9 ITGA2B ITGB3 VWF
7 11.87 GP1BA ITGA2B ITGB3 MPL THPO
8
Show member pathways
11.79 F2 F7 F9
9 11.75 GP1BA GP9 ITGA2B ITGB3 THPO
10
Show member pathways
11.75 F2 GP1BA GP9 ITGA2B ITGB3 MPL
11 11.68 F3 ITGB3 VWF
12
Show member pathways
11.57 F2 F3 F7 F8 F9 GP1BA
13 11.43 F2 GP9 ITGA2B ITGB3 VWF
14 11.39 GP9 ITGA2B ITGB3
15 10.88 F2 F7 F9
16 10.87 CD40LG ITGA2B ITGB3 PF4 THPO
17 10.8 GP1BA GP9 VWF
18 10.63 GP1BA GP9 VWF

GO Terms for Blood Coagulation Disease

Cellular components related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADAMTS13 CD40LG F2 F3 F7 F8
2 endoplasmic reticulum lumen GO:0005788 9.63 ADAMTS13 F2 F7 F8 F9 SERPINC1
3 Golgi lumen GO:0005796 9.61 F2 F7 F9
4 platelet alpha granule lumen GO:0031093 9.58 F8 PF4 VWF
5 platelet alpha granule membrane GO:0031092 9.46 ITGA2B ITGB3
6 serine-type peptidase complex GO:1905286 9.32 F3 F7
7 cell surface GO:0009986 9.23 ADAMTS13 CD40LG F3 GP1BA ITGA2B ITGB3
8 plasma membrane GO:0005886 10.18 CD40LG F2 F3 F7 F8 F9
9 extracellular region GO:0005576 10 ADAMTS13 CD40LG F2 F3 F7 F8

Biological processes related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F2 F7 F8 F9
2 cytokine-mediated signaling pathway GO:0019221 9.81 F3 GP1BA MPL PF4
3 platelet activation GO:0030168 9.81 ADAMTS13 CD40LG F2 F8 GP1BA GP9
4 cell-matrix adhesion GO:0007160 9.77 ADAMTS13 ITGA2B ITGB3
5 integrin-mediated signaling pathway GO:0007229 9.77 ADAMTS13 ITGA2B ITGB3
6 platelet degranulation GO:0002576 9.77 F8 ITGA2B ITGB3 PF4 VWF
7 blood coagulation, intrinsic pathway GO:0007597 9.73 F2 F8 F9 GP1BA GP9 VWF
8 blood coagulation GO:0007596 9.73 ADAMTS13 F2 F3 F7 F8 F9
9 regulation of megakaryocyte differentiation GO:0045652 9.72 GP1BA ITGA2B PF4
10 protein processing GO:0016485 9.71 ADAMTS13 F3 F7
11 regulation of blood coagulation GO:0030193 9.63 F2 GP1BA SERPINC1
12 cell-substrate adhesion GO:0031589 9.61 ITGB3 VWF
13 signal peptide processing GO:0006465 9.61 F2 F7 F9
14 positive regulation of blood coagulation GO:0030194 9.58 F2 F7
15 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
16 peptidyl-glutamic acid carboxylation GO:0017187 9.58 F2 F7 F9
17 negative regulation of fibrinolysis GO:0051918 9.57 F2 THBD
18 negative regulation of platelet activation GO:0010544 9.56 F2 THBD
19 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
20 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.49 F3 F7
21 thrombopoietin-mediated signaling pathway GO:0038163 9.48 MPL THPO
22 hemostasis GO:0007599 9.36 ADAMTS13 F2 F3 F7 F8 F9

Molecular functions related to Blood Coagulation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ADAMTS13 CD40LG F2 F3 F7 F8
2 serine-type endopeptidase activity GO:0004252 9.46 F2 F3 F7 F9
3 protease binding GO:0002020 8.92 F3 ITGB3 SERPINC1 VWF

Sources for Blood Coagulation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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