MCID: BLT003
MIFTS: 38

Blue Toe Syndrome malady

Category: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

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Aliases & Descriptions for Blue Toe Syndrome:

Name: Blue Toe Syndrome 10 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:14121
MeSH36 D018438
UMLS65 C0242645

Summaries for Blue Toe Syndrome

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Wikipedia:68 Blue toe syndrome is a situation of atherothrombotic microembolism, causing transient focal ischaemia,... more...

MalaCards based summary: Blue Toe Syndrome is related to cholesterol embolism and pericardial mesothelioma. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways are Syndecan-4-mediated signaling events and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include breast, colon and skin, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Blue Toe Syndrome

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Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1cholesterol embolism11.6
2pericardial mesothelioma10.7F2, SERPINC1
3thrombophilia due to thrombin defect10.6F2, SERPINC1
4cerebrovascular disease10.6F2, SERPINC1
5sesame syndrome10.6F2, SERPINC1
6maple bark strippers' lung10.6F2, SERPINC1
7beach ear10.6CRP, F2
8colonic pseudo-obstruction10.6F2, SERPINC1
9rickettsia parkeri spotted fever10.6CRP, SERPINC1
10diffuse meningeal melanocytosis10.6F2, SERPINC1
11esophagitis10.6CRP, F2
12askin's tumor10.6CRP, F2
13facial nerve disease10.6F2, SERPINC1
14liver failure acute infantile10.5F2, SERPINE1
15protein s deficiency10.5F2, SERPINC1
16rhinoscleroma10.5CRP, LYZ
17acrodermatitis10.5F2, SERPINC1
18acute allergic mucoid otitis media10.5CRP, LYZ
19oral squamous cell carcinoma10.5CRP, F2
20senile cataract10.5F2, SERPINC1
21homocystinuria due to cbs deficiency10.5CRP, F2
22sertoli cell tumor10.5F3, SERPINC1
23central nervous system osteosarcoma10.5F2, F3
24splenic infarction10.5CRP, F2
25epiglottitis10.5F2, F3
26dysgnathia complex10.5F2, SERPINC1
27von willibrand disease, type 310.5F2, F3
28stickler sydrome, type i, nonsyndromic ocular10.5SERPINC1, SERPINE1
29vaginal villous adenoma10.5F2, F3
30apical myocardial infarction10.5KIAA0101, SERPINC1
31hemosiderosis10.5CRP, LYZ
32herpes gestationis10.5F2, F3
33meningoencephalocele10.5SERPINC1, SERPINE1
34acquired thrombocytopenia10.4F2, F3
35hypertrichosis10.4F2, F3
36narcissistic personality disorder10.4CRP, LYZ
37pestis minor10.4KIAA0101, LYZ
38microcytic anemia10.4F2, F3
39splenic abscess10.4F2, F3
40skull base meningioma10.4F2, F3
41angioedema, hereditary, type iii10.4F3, SERPINC1
42budd-chiari syndrome10.4F2, SERPINC1
43facioscapulohumeral muscular dystrophy 110.4F2, F3
44labyrinthine unilateral reactive loss10.4CRP, LYZ
45keratomalacia10.4CRP, SERPINC1
46ischemic optic neuropathy10.4CRP, F3
47lateral sclerosis10.4CRP, F2
48catatrichy10.3F3, SERPINE1
49thrombocytopenia cerebellar hypoplasia short stature10.3F2, F3
50glossopharyngeal nerve neoplasm10.3F3, SERPINE1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to blue toe syndrome

Symptoms for Blue Toe Syndrome

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Drugs & Therapeutics for Blue Toe Syndrome

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Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineexperimentalPhase 468951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 414795
3OnabotulinumtoxinAPhase 4588
4VasopressinsPhase 4260
5Neuromuscular AgentsPhase 4922
6Peripheral Nervous System AgentsPhase 418510
7Cholinergic AgentsPhase 43243
8Arginine VasopressinPhase 4264
9Botulinum ToxinsPhase 4616
10Botulinum Toxins, Type APhase 4588
11AbobotulinumtoxinAPhase 4588
12IncobotulinumtoxinAPhase 4599

Interventional clinical trials:

idNameStatusNCT IDPhase
1Botulinum Toxin A for Treatment of Catocholamine Induced Finger NecrosisRecruitingNCT01500668Phase 4

Search NIH Clinical Center for Blue Toe Syndrome


Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

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Anatomical Context for Blue Toe Syndrome

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MalaCards organs/tissues related to Blue Toe Syndrome:

33
Breast, Colon, Skin, Thyroid, Tongue, T cells, Prostate

Animal Models for Blue Toe Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Blue Toe Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8ARG1, LYZ, PLG, SERPINC1, SERPINE1
2MP:00107717.7F2, F3, LYZ, PLG, RBMS1, SERPINE1
3MP:00053857.3CRP, F2, F3, LYZ, PLG, SERPINC1
4MP:00053977.0ARG1, F2, F3, KIAA0101, LYZ, PLG
5MP:00107686.8ARG1, F2, F3, LYZ, PLG, RBMS1
6MP:00053766.4ARG1, CRP, F2, F3, LYZ, PLG
7MP:00053876.3ARG1, CRP, F2, F3, KIAA0101, LYZ

Publications for Blue Toe Syndrome

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Articles related to Blue Toe Syndrome:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Blue toe syndrome, ischemic pain treated with digital block. (25605677)
2015
2
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. (24861307)
2014
3
Blue toe syndrome--reply. (24810698)
2014
4
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. (24810697)
2014
5
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. (25534490)
2014
6
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. (23764710)
2013
7
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. (26877940)
2013
8
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. (24426603)
2013
9
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. (22983548)
2012
10
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. (21571496)
2011
11
Blue toe syndrome and sunitinib. (21136131)
2011
12
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. (23074585)
2010
13
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. (20609674)
2010
14
Blue toe syndrome as a clue to the underlying cause of acute renal failure. (25949485)
2010
15
Blue toe syndrome. (17906493)
2007
16
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. (16520732)
2006
17
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. (16874430)
2006
18
Case report: Blue toe syndrome caused by a true crural aneurysm. (12813416)
2003
19
Blue toe syndrome: a rare complication of acute pancreatitis. (12555011)
2003
20
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. (12376800)
2002
21
Angioplasty with stenting is effective in treating blue toe syndrome. (11951102)
2002
22
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. (12152242)
2002
23
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. (11341514)
2001
24
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
25
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. (10498409)
1999
26
Blue toe syndrome after initiation of low-dose oral anticoagulation. (9620888)
1998
27
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. (9044465)
1997
28
Evaluation and management of cholesterol embolization and the blue toe syndrome. (8889381)
1996
29
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. (8943451)
1996
30
Additional causes of the blue toe syndrome. (7791402)
1995
31
Blue toe syndrome from a "coral reef" aorta. (8746834)
1995
32
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. (7963875)
1994
33
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. (8284757)
1994
34
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. (8214780)
1993
35
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. (1535174)
1992
36
Blue toe syndrome. Causes and management. (1444678)
1992
37
Blue toe syndrome. (1747352)
1991
38
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. (2240906)
1990
39
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. (2324190)
1990
40
Blue toe syndrome: treatment with percutaneous atherectomy. (2813788)
1989
41
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. (2962224)
1988
42
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. (3246660)
1988
43
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. (3512857)
1986
44
Blue toe syndrome. (3716963)
1986
45
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. (6507759)
1984
46
Blue toe syndrome--a warning sign of unsuspected vascular injury. (6221428)
1983
47
Blue toe syndrome. A case presentation. (6655197)
1983
48
Experience with the Blue Toe Syndrome. (7076462)
1982
49
Blue toe syndrome. (7108117)
1982
50
Bilateral blue toe syndrome. A case report. (7351752)
1980

Variations for Blue Toe Syndrome

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Expression for genes affiliated with Blue Toe Syndrome

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Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for genes affiliated with Blue Toe Syndrome

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GO Terms for genes affiliated with Blue Toe Syndrome

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Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hydrogen peroxideGO:007030110.1ARG1, F3
2positive regulation of blood coagulationGO:00301949.8F2, SERPINE1
3fibrinolysisGO:00427309.5PLG, SERPINE1
4response to woundingGO:00096119.3ARG1, F2, F3
5blood coagulationGO:00075969.1F2, PLG, SERPINE1

Sources for Blue Toe Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet