MCID: BLT003
MIFTS: 35

Blue Toe Syndrome malady

Category: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

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Aliases & Descriptions for Blue Toe Syndrome:

Name: Blue Toe Syndrome 11 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:14121
MeSH39 D018438

Summaries for Blue Toe Syndrome

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Wikipedia:71 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

MalaCards based summary: Blue Toe Syndrome is related to cholesterol embolism and vascular erectile tumor. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Syndecan-4-mediated signaling events. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Related Diseases for Blue Toe Syndrome

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Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1cholesterol embolism11.7
2vascular erectile tumor10.3F2, SERPINC1
3peanut allergy10.3F2, SERPINC1
4may-hegglin anomaly10.3F2, SERPINC1
5acute infection of pinna10.3CRP, F2
6left-right axis malformations10.3F2, SERPINC1
7stt3a-cdg and stt3b-cdg10.3SERPINC1, SERPINE1
8citrulline transport defect10.3CRP, F2
9synostosis10.3CRP, F2
10brazilian hemorrhagic fever10.3SERPINC1, SERPINE1
11lubinsky syndrome10.2F2, SERPINE1
12cataract10.2CRP, SERPINC1
13oropharyngeal anthrax10.2CRP, SERPINC1
14sertoli cell tumor10.2F3, SERPINC1
15cerebellar astrocytoma10.2F2, SERPINC1
16hereditary endotheliopathy, retinopathy, nephropathy, and stroke10.2F3, SERPINC1
17angelucci's syndrome10.2F2, SERPINC1
18alpha-2-macroglobulin deficiency10.2F2, F3
19hendra virus infection10.2F2, F3
20hypertrichosis10.2F3, SERPINC1
21prostatic hypertrophy10.2F2, F3
22dyskinetic cerebral palsy10.2F2, F3
23stroke, ischemic10.2F2, F3
24sporotrichosis10.2F2, F3
25cryptosporidiosis10.2F2, SERPINC1
26neuronopathy, distal hereditary motor, type iid10.2F3, SERPINC1
27chronic inflammatory demyelinating polyneuritis10.2F2, F3
28glutathionuria10.2F2, SERPINE1
29fletcher factor deficiency10.2F2, F3
30silent myocardial infarction10.2PCLAF, SERPINC1
31conjunctivochalasis10.2F3, SERPINC1
32angular blepharoconjunctivitis10.2F2, SERPINC1
33sulfhemoglobinemia10.2F3, PLG
34lymphocytic colitis10.2F2, SERPINC1, SERPINE1
35bullous skin disease10.2F2, SERPINC1, SERPINE1
36neuroaxonal dystrophy10.2F2, SERPINC1, SERPINE1
37periosteal chondrosarcoma10.2F2, SERPINC1, SERPINE1
38lynch syndrome10.2F2, SERPINC1, SERPINE1
39pyelonephritis10.2CRP, F2, SERPINC1
40dysgammaglobulinemia10.2F2, SERPINC1, SERPINE1
41asbestosis10.2CRP, F2, SERPINC1
42subclavian artery aneurysm10.2F3, SERPINE1
43generalized anxiety disorder10.2PLG, SERPINE1
44czech dysplasia10.2SERPINC1, SERPINE1
45central congenital hypothyroidism10.2F3, SERPINE1
46myotonic dystrophy10.2F2, F3
47scar contracture10.1F2, SERPINC1, SERPINE1
48freiberg's disease10.1F2, F3, SERPINC1
49pancreatic ductal carcinoma10.1F2, F3, SERPINC1
50ovarian papillary cystadenoma10.1F2, SERPINC1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to blue toe syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

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MGI Mouse Phenotypes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6ARG1, LYZ, PLG, SERPINC1, SERPINE1
2MP:00053858.6CRP, F2, F3, LYZ, PLG, SERPINC1
3MP:00107718.3F2, F3, LYZ, PLG, RBMS1, SERPINE1
4MP:00053978.1ARG1, F2, F3, LYZ, PCLAF, PLG
5MP:00053877.7ARG1, CRP, F2, F3, LYZ, PCLAF
6MP:00053767.4ARG1, CRP, F2, F3, LYZ, PLG

Drugs & Therapeutics for Blue Toe Syndrome

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Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 480551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 418340
3onabotulinumtoxinAPhase 4652
4VasopressinsPhase 4294
5Neuromuscular AgentsPhase 41180
6Peripheral Nervous System AgentsPhase 423689
7Cholinergic AgentsPhase 43992
8Arginine VasopressinPhase 4299
9Botulinum ToxinsPhase 4697
10Botulinum Toxins, Type APhase 4657
11abobotulinumtoxinAPhase 4652
12incobotulinumtoxinAPhase 4662

Interventional clinical trials:

idNameStatusNCT IDPhase
1Botulinum Toxin A for Treatment of Catocholamine Induced Finger NecrosisUnknown statusNCT01500668Phase 4

Search NIH Clinical Center for Blue Toe Syndrome


Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

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Anatomical Context for Blue Toe Syndrome

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MalaCards organs/tissues related to Blue Toe Syndrome:

36
Skin, Bone, Bone marrow

Publications for Blue Toe Syndrome

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Articles related to Blue Toe Syndrome:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. (27274647)
2016
2
Blue toe syndrome, ischemic pain treated with digital block. (25605677)
2015
3
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. (24861307)
2014
4
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. (25534490)
2014
5
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. (24810697)
2014
6
Blue toe syndrome--reply. (24810698)
2014
7
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. (23764710)
2013
8
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. (26877940)
2013
9
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. (24426603)
2013
10
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. (22983548)
2012
11
Blue toe syndrome and sunitinib. (21136131)
2011
12
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. (21571496)
2011
13
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. (23074585)
2010
14
Blue toe syndrome as a clue to the underlying cause of acute renal failure. (25949485)
2010
15
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. (20609674)
2010
16
Blue toe syndrome. (17906493)
2007
17
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. (16874430)
2006
18
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. (16520732)
2006
19
Case report: Blue toe syndrome caused by a true crural aneurysm. (12813416)
2003
20
Blue toe syndrome: a rare complication of acute pancreatitis. (12555011)
2003
21
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. (12376800)
2002
22
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. (12152242)
2002
23
Angioplasty with stenting is effective in treating blue toe syndrome. (11951102)
2002
24
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. (11341514)
2001
25
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. (10834489)
2000
26
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
27
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. (10498409)
1999
28
Blue toe syndrome after initiation of low-dose oral anticoagulation. (9620888)
1998
29
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. (9044465)
1997
30
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. (8943451)
1996
31
Evaluation and management of cholesterol embolization and the blue toe syndrome. (8889381)
1996
32
Blue toe syndrome from a "coral reef" aorta. (8746834)
1995
33
Additional causes of the blue toe syndrome. (7791402)
1995
34
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. (7963875)
1994
35
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. (8284757)
1994
36
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. (8214780)
1993
37
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. (1535174)
1992
38
Blue toe syndrome. Causes and management. (1444678)
1992
39
Blue toe syndrome. (1747352)
1991
40
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. (2240906)
1990
41
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. (2324190)
1990
42
Blue toe syndrome: treatment with percutaneous atherectomy. (2813788)
1989
43
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. (2962224)
1988
44
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. (3246660)
1988
45
Blue toe syndrome. (3716963)
1986
46
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. (3512857)
1986
47
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. (6507759)
1984
48
Blue toe syndrome--a warning sign of unsuspected vascular injury. (6221428)
1983
49
Blue toe syndrome. A case presentation. (6655197)
1983
50
Experience with the Blue Toe Syndrome. (7076462)
1982

Variations for Blue Toe Syndrome

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Expression for genes affiliated with Blue Toe Syndrome

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Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for genes affiliated with Blue Toe Syndrome

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GO Terms for genes affiliated with Blue Toe Syndrome

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Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:007256210.1F2, PLG, SERPINC1
2extracellular exosomeGO:00700628.2ARG1, CRP, F2, F3, LYZ, PLG
3extracellular regionGO:00055768.2ARG1, CRP, F2, F3, LYZ, PLG
4extracellular spaceGO:00056157.5ARG1, CRP, F2, F3, LYZ, PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:000695310.4CRP, F2
2positive regulation of blood coagulationGO:003019410.1F2, SERPINE1
3regulation of blood coagulationGO:00301939.9F2, SERPINC1
4fibrinolysisGO:00427309.7F2, PLG, SERPINE1
5negative regulation of fibrinolysisGO:00519189.6F2, PLG, SERPINE1
6cellular protein metabolic processGO:00442679.5F2, LYZ, PLG, SERPINC1
7blood coagulationGO:00075969.5F2, F3, PLG, SERPINC1
8hemostasisGO:00075999.3F2, F3, PLG, SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.3F3, SERPINC1, SERPINE1

Sources for Blue Toe Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet