MCID: BLT003
MIFTS: 33

Blue Toe Syndrome malady

Category: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

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Aliases & Descriptions for Blue Toe Syndrome:

Name: Blue Toe Syndrome 11 13 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:14121
MeSH37 D018438

Summaries for Blue Toe Syndrome

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Wikipedia:69 Blue toe syndrome is a situation of atherothrombotic microembolism, causing transient focal ischaemia,... more...

MalaCards based summary: Blue Toe Syndrome is related to cholesterol embolism and acrodysostosis. An important gene associated with Blue Toe Syndrome is BRD4 (Bromodomain Containing 4), and among its related pathways are Syndecan-4-mediated signaling events and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Blue Toe Syndrome

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Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1cholesterol embolism11.6
2acrodysostosis10.7ARG1, BRD4
3glandular tularemia10.7BRD4, F2
4subcortical arteriosclerotic encephalopathy10.7F2, SERPINC1
5diabetic autonomic neuropathy10.7BRD4, F2
6milk allergy10.6F2, SERPINC1
7spleen cancer10.6F2, SERPINC1
8thrombophilia due to thrombin defect10.6F2, SERPINC1
9may-hegglin anomaly10.6F2, SERPINC1
10left-right axis malformations10.6F2, SERPINC1
11pericholangitis10.6BRD4, F2
12histoplasmosis10.6F2, SERPINC1
13budd-chiari syndrome10.6F2, SERPINC1
14pemphigus10.6BRD4, CRP
15thrombophilia10.6F2, SERPINC1
16chronic fungal otitis externa10.5CRP, F2
17postmenopausal atrophic vaginitis10.5CRP, F2
18cartilage disease10.5CRP, SERPINC1
19oral cavity carcinoma in situ10.5CRP, F2
20anterior foramen magnum meningioma10.5F2, SERPINC1
21rocky mountain spotted fever10.5CRP, SERPINC1
22hypoactive sexual desire disorder10.5BRD4, CRP
23homocystinuria due to defect in methylation cbl g10.5CRP, F2
24venezuelan hemorrhagic fever10.5SERPINC1, SERPINE1
25pyrimidine metabolic disorder10.5BRD4, CRP
26lemierre's syndrome10.5CRP, LYZ
27unicentric castleman disease10.5F2, SERPINE1
28subendocardial myocardial infarction10.5KIAA0101, SERPINC1
29hepatocellular adenoma10.4CRP, F2
30blue drum syndrome10.4CRP, LYZ
31polyneuropathy due to drug10.4BRD4, CRP
32adiaspiromycosis10.4KIAA0101, LYZ
33facial hemiatrophy10.4BRD4, F2, SERPINC1
34stickler sydrome, type i, nonsyndromic ocular10.4SERPINC1, SERPINE1
35west nile fever10.4F2, SERPINE1
36cavernous sinus thrombosis10.4F3, SERPINC1
37hepatic fibrosis renal cysts mental retardation10.4F3, SERPINC1
38epidural neoplasm10.4BRD4, LYZ
39elejalde disease10.4F2, SERPINE1
40choroiditis10.4CRP, LYZ
41familial glomangioma10.4F2, F3
42gastric hemangioma10.4CRP, LYZ
43malignant hypertension10.4BRD4, PLG
44chronic inflammatory demyelinating polyneuritis10.4CRP, F2
45cerebral angioma10.4F2, F3
46classic congenital lipoid adrenal hyperplasia due to star deficency10.4F2, F3
47joint disorders10.4F2, SERPINC1
48dislocation of ear ossicle10.4F2, F3
49von willibrand disease, type 310.3F2, F3
50brill-zinsser disease10.3F2, F3

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to blue toe syndrome

Symptoms for Blue Toe Syndrome

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Drugs & Therapeutics for Blue Toe Syndrome

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Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholinePhase 475251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

idNameStatusNCT IDPhase
1Botulinum Toxin A for Treatment of Catocholamine Induced Finger NecrosisRecruitingNCT01500668Phase 4

Search NIH Clinical Center for Blue Toe Syndrome


Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

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Anatomical Context for Blue Toe Syndrome

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MalaCards organs/tissues related to Blue Toe Syndrome:

34
Skin, Bone, Bone marrow

Animal Models for Blue Toe Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Blue Toe Syndrome:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9ARG1, LYZ, PLG, SERPINC1, SERPINE1
2MP:00107717.8F2, F3, LYZ, PLG, RBMS1, SERPINE1
3MP:00053977.2ARG1, F2, F3, KIAA0101, LYZ, PLG
4MP:00053857.1CRP, F2, F3, LYZ, PLG, SERPINC1
5MP:00053876.9ARG1, CRP, F2, F3, KIAA0101, LYZ
6MP:00053766.3ARG1, CRP, F2, F3, LYZ, PLG

Publications for Blue Toe Syndrome

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Articles related to Blue Toe Syndrome:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. (27274647)
2016
2
Blue toe syndrome, ischemic pain treated with digital block. (25605677)
2015
3
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. (24810697)
2014
4
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. (25534490)
2014
5
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. (24861307)
2014
6
Blue toe syndrome--reply. (24810698)
2014
7
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. (26877940)
2013
8
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. (23764710)
2013
9
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. (24426603)
2013
10
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. (22983548)
2012
11
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. (21571496)
2011
12
Blue toe syndrome and sunitinib. (21136131)
2011
13
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. (23074585)
2010
14
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. (20609674)
2010
15
Blue toe syndrome as a clue to the underlying cause of acute renal failure. (25949485)
2010
16
Blue toe syndrome. (17906493)
2007
17
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. (16520732)
2006
18
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. (16874430)
2006
19
Case report: Blue toe syndrome caused by a true crural aneurysm. (12813416)
2003
20
Blue toe syndrome: a rare complication of acute pancreatitis. (12555011)
2003
21
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. (12376800)
2002
22
Angioplasty with stenting is effective in treating blue toe syndrome. (11951102)
2002
23
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. (11341514)
2001
24
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. (10834489)
2000
25
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
26
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. (10498409)
1999
27
Blue toe syndrome after initiation of low-dose oral anticoagulation. (9620888)
1998
28
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. (9044465)
1997
29
Evaluation and management of cholesterol embolization and the blue toe syndrome. (8889381)
1996
30
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. (8943451)
1996
31
Additional causes of the blue toe syndrome. (7791402)
1995
32
Blue toe syndrome from a "coral reef" aorta. (8746834)
1995
33
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. (7963875)
1994
34
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. (8284757)
1994
35
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. (8214780)
1993
36
Blue toe syndrome. Causes and management. (1444678)
1992
37
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. (1535174)
1992
38
Blue toe syndrome. (1747352)
1991
39
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. (2324190)
1990
40
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. (2240906)
1990
41
Blue toe syndrome: treatment with percutaneous atherectomy. (2813788)
1989
42
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. (2962224)
1988
43
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. (3246660)
1988
44
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. (3512857)
1986
45
Blue toe syndrome. (3716963)
1986
46
Blue toe syndrome. A case presentation. (6655197)
1983
47
Blue toe syndrome--a warning sign of unsuspected vascular injury. (6221428)
1983
48
Blue toe syndrome. (7108117)
1982
49
Experience with the Blue Toe Syndrome. (7076462)
1982
50
Bilateral blue toe syndrome. A case report. (7351752)
1980

Variations for Blue Toe Syndrome

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Expression for genes affiliated with Blue Toe Syndrome

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Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for genes affiliated with Blue Toe Syndrome

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GO Terms for genes affiliated with Blue Toe Syndrome

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Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.7F2, PLG, SERPINC1
2extracellular regionGO:00055767.9CRP, F2, LYZ, PLG, SERPINC1, SERPINE1
3extracellular exosomeGO:00700627.1ARG1, CRP, F2, F3, LYZ, PLG
4extracellular spaceGO:00056156.8ARG1, CRP, F2, F3, LYZ, PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:00301949.7F2, SERPINE1
2fibrinolysisGO:00427309.5F2, PLG, SERPINE1
3negative regulation of fibrinolysisGO:00519189.5F2, PLG, SERPINE1
4cellular protein metabolic processGO:00442679.5F2, LYZ, PLG
5blood coagulationGO:00075968.8F2, F3, PLG, SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.0F3, SERPINC1, SERPINE1
2serine-type endopeptidase activityGO:00042528.8F2, F3, PLG

Sources for Blue Toe Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet