MCID: BLT003
MIFTS: 33

Blue Toe Syndrome malady

Category: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

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Aliases & Descriptions for Blue Toe Syndrome:

Name: Blue Toe Syndrome 10 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:14121
MeSH36 D018438
UMLS65 C0242645

Summaries for Blue Toe Syndrome

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Wikipedia:68 Blue toe syndrome is a situation of atherothrombotic microembolism, causing transient focal ischaemia,... more...

MalaCards based summary: Blue Toe Syndrome is related to myocardial infarction and cholesterol embolism. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Syndecan-4-mediated signaling events. Affiliated tissues include thyroid, adipocyte and salivary gland, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Blue Toe Syndrome

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Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction29.1CRP, F2, F3, PLG, SERPINC1, SERPINE1
2cholesterol embolism11.8
3pericardial mesothelioma10.4F2, SERPINC1
4thrombophilia due to thrombin defect10.4F2, SERPINC1
5cerebrovascular disease10.4F2, SERPINC1
6sesame syndrome10.4F2, SERPINC1
7maple bark strippers' lung10.4F2, SERPINC1
8beach ear10.4CRP, F2
9colonic pseudo-obstruction10.4F2, SERPINC1
10rickettsia parkeri spotted fever10.4CRP, SERPINC1
11diffuse meningeal melanocytosis10.4F2, SERPINC1
12esophagitis10.4CRP, F2
13askin's tumor10.4CRP, F2
14facial nerve disease10.4F2, SERPINC1
15liver failure acute infantile10.4F2, SERPINE1
16protein s deficiency10.3F2, SERPINC1
17rhinoscleroma10.3CRP, LYZ
18acrodermatitis10.3F2, SERPINC1
19acute allergic mucoid otitis media10.3CRP, LYZ
20oral squamous cell carcinoma10.3CRP, F2
21lymphoma10.3
22pneumonia10.3
23senile cataract10.3F2, SERPINC1
24homocystinuria due to cbs deficiency10.3CRP, F2
25sertoli cell tumor10.3F3, SERPINC1
26central nervous system osteosarcoma10.3F2, F3
27splenic infarction10.3CRP, F2
28epiglottitis10.3F2, F3
29dysgnathia complex10.3F2, SERPINC1
30von willibrand disease, type 310.3F2, F3
31stickler sydrome, type i, nonsyndromic ocular10.3SERPINC1, SERPINE1
32vaginal villous adenoma10.3F2, F3
33apical myocardial infarction10.3KIAA0101, SERPINC1
34hemosiderosis10.3CRP, LYZ
35herpes gestationis10.3F2, F3
36meningoencephalocele10.3SERPINC1, SERPINE1
37acquired thrombocytopenia10.3F2, F3
38hypertrichosis10.3F2, F3
39narcissistic personality disorder10.3CRP, LYZ
40pestis minor10.3KIAA0101, LYZ
41microcytic anemia10.3F2, F3
42splenic abscess10.3F2, F3
43skull base meningioma10.3F2, F3
44angioedema, hereditary, type iii10.3F3, SERPINC1
45budd-chiari syndrome10.3F2, SERPINC1
46facioscapulohumeral muscular dystrophy 110.3F2, F3
47labyrinthine unilateral reactive loss10.3CRP, LYZ
48keratomalacia10.3CRP, SERPINC1
49ischemic optic neuropathy10.2CRP, F3
50lateral sclerosis10.2CRP, F2

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to blue toe syndrome

Symptoms for Blue Toe Syndrome

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Drugs & Therapeutics for Blue Toe Syndrome

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Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineexperimentalPhase 468951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 414795
3OnabotulinumtoxinAPhase 4588
4VasopressinsPhase 4260
5Neuromuscular AgentsPhase 4922
6Peripheral Nervous System AgentsPhase 418510
7Cholinergic AgentsPhase 43243
8Arginine VasopressinPhase 4264
9Botulinum ToxinsPhase 4616
10Botulinum Toxins, Type APhase 4588
11AbobotulinumtoxinAPhase 4588
12IncobotulinumtoxinAPhase 4599

Interventional clinical trials:

idNameStatusNCT IDPhase
1Botulinum Toxin A for Treatment of Catocholamine Induced Finger NecrosisRecruitingNCT01500668Phase 4

Search NIH Clinical Center for Blue Toe Syndrome


Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

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Anatomical Context for Blue Toe Syndrome

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MalaCards organs/tissues related to Blue Toe Syndrome:

33
Thyroid, Adipocyte, Salivary gland, Breast, B cells, T cells, Prostate

Animal Models for Blue Toe Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Blue Toe Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8ARG1, LYZ, PLG, SERPINC1, SERPINE1
2MP:00107717.7F2, F3, LYZ, PLG, RBMS1, SERPINE1
3MP:00053857.3CRP, F2, F3, LYZ, PLG, SERPINC1
4MP:00053977.0ARG1, F2, F3, KIAA0101, LYZ, PLG
5MP:00107686.8ARG1, F2, F3, LYZ, PLG, RBMS1
6MP:00053766.4ARG1, CRP, F2, F3, LYZ, PLG
7MP:00053876.3ARG1, CRP, F2, F3, KIAA0101, LYZ

Publications for Blue Toe Syndrome

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Articles related to Blue Toe Syndrome:

(show all 50)
idTitleAuthorsYear
1
Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. (25607530)
2015
2
Intra-operative post-induction hyperthermia, possibly malignant hyperthermia: Anesthetic implications, challenges and management. (25425784)
2014
3
99mTcO4- accumulation in scintigraphy and expression of Na+/I- symporter in salivary gland tumors. (25199743)
2014
4
PET imaging of neuropathology in tauopathies: progressive supranuclear palsy. (23579330)
2013
5
Follicular Variant of Papillary Carcinoma Presenting as a Hyperfunctioning Thyroid Nodule. (24072237)
2013
6
SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects. (23940069)
2013
7
In regard to Boomsma et al. Re: A prospective cohort study on radiation-induced hypothyroidism: development of an NTCP model. (23237002)
2013
8
Dignity and care for people with dementia living in nursing homes. (24381212)
2013
9
Effect of age at onset on disease characteristics in vitiligo. (23815958)
2013
10
Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients. (21837675)
2012
11
Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells. (21630295)
2012
12
Benign fibrous histiocytoma of the conjunctiva. (23320226)
2012
13
Facetal distraction as treatment for single- and multilevel cervical spondylotic radiculopathy and myelopathy: a preliminary report. (21417697)
2011
14
Alzheimer's disease genes are associated with measures of cognitive ageing in the lothian birth cohorts of 1921 and 1936. (21766012)
2011
15
Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain. (20708621)
2010
16
Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. (20056825)
2010
17
Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands. (20068181)
2010
18
Craniofacial characteristics in cri-du-chat syndrome. (21112524)
2010
19
Comparison of cardiovascular risk in ankylosing spondylitis and rheumatoid arthritis. (19822058)
2009
20
A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G. (19535450)
2009
21
Administration of nanodrugs in proper menstrual stage for maximal drug retention in breast cancer. (18299174)
2008
22
Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy. (18519448)
2008
23
Lichen sclerosus et atrophicus of the lip: successful treatment with topical tacrolimus. (18031502)
2008
24
Cutaneous clues to drug addiction. (18380215)
2008
25
Comparison of the safety and immunogenicity of a refrigerator-stable versus a frozen formulation of ProQuad (measles, mumps, rubella, and varicella virus vaccine live). (17502347)
2007
26
Metastatic B-cell lymphoma of the cecum masquerading as Tolosa-Hunt syndrome. (17392865)
2007
27
The role of high affinity non-specific DNA binding by Lrp in transcriptional regulation and DNA organization. (17498742)
2007
28
Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study. (17575217)
2007
29
Character and temperament in major depressive disorder and a highly anxious-retarded subtype derived from melancholia. (17707250)
2007
30
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. (16731834)
2006
31
Is disseminated juvenile xanthogranulomatosis benign cephalic histiocytosis? (15660896)
2005
32
Surgical revascularization versus amputation for peripheral vascular disease in dialysis patients: a cohort study. (15780133)
2005
33
Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy. (15349815)
2004
34
UV induces VEGF through a TNF-alpha independent pathway. (12551841)
2003
35
The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192). (15037822)
2003
36
Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite. (12196478)
2002
37
Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer. (11972550)
2002
38
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. (10721995)
2000
39
Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects. (10090472)
1999
40
The proteoglycans of human cementum: immunohistochemical localization in healthy, periodontally involved and ageing teeth. (10207837)
1999
41
Structural and functional domains of the troponin complex revealed by limited digestion. (9219516)
1997
42
Transcriptional regulation of gene expression during adipocyte differentiation. (7574486)
1995
43
Effect of continuous positive airway pressure on central sleep apnea and nocturnal PCO2 in heart failure. (7952621)
1994
44
Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes. (8085791)
1993-1994
45
Autosplenectomy complicating pneumococcal meningitis in an adult. (2025150)
1991
46
Problems in diabetes mellitus management. Insulin resistance. (2134077)
1990
47
Arachidonic acid inhibits luteinizing hormone-stimulated progesterone production in hen granulosa cells. (2111185)
1990
48
Urgent endoscopic drainage for acute suppurative cholangitis. (2566834)
1989
49
Transferase-deficiency galactosemia and the Duarte variant. (3795401)
1987
50
The Chediak-Higashi syndrome: cytoplasmic sequestration in circulating leukocytes. (6023060)
1967

Variations for Blue Toe Syndrome

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Expression for genes affiliated with Blue Toe Syndrome

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Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for genes affiliated with Blue Toe Syndrome

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GO Terms for genes affiliated with Blue Toe Syndrome

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Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hydrogen peroxideGO:007030110.1ARG1, F3
2positive regulation of blood coagulationGO:00301949.8F2, SERPINE1
3fibrinolysisGO:00427309.5PLG, SERPINE1
4response to woundingGO:00096119.3ARG1, F2, F3
5blood coagulationGO:00075969.1F2, PLG, SERPINE1

Sources for Blue Toe Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet