MCID: BLT003
MIFTS: 38

Blue Toe Syndrome

Categories: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 41 D018438
UMLS 69 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to disseminated intravascular coagulation and cholesterol embolism. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 28.6 F2 F3 PLG SERPINC1 SERPINE1
2 cholesterol embolism 11.8
3 spinal cord infarction 10.5 F2 SERPINC1
4 sudden sensorineural hearing loss 10.4 F2 SERPINC1
5 blood protein disease 10.4 F2 SERPINC1
6 prothrombin deficiency, congenital 10.4 F2 SERPINC1
7 sneddon syndrome 10.4 F2 SERPINC1
8 esophageal varix 10.4 F2 SERPINC1
9 malignant otitis externa 10.4 CRP F2
10 antithrombin iii deficiency 10.4 F2 SERPINC1
11 japanese spotted fever 10.4 CRP SERPINC1
12 fibrinolytic defect 10.4 SERPINC1 SERPINE1
13 ischemic neuropathy 10.4 CRP F2
14 argentine hemorrhagic fever 10.4 SERPINC1 SERPINE1
15 sticky platelet syndrome 10.4 SERPINC1 SERPINE1
16 hypersplenism 10.4 F2 SERPINC1
17 livedoid vasculopathy 10.3 F2 SERPINE1
18 central retinal vein occlusion 10.3 F2 SERPINC1
19 cryptogenic cirrhosis 10.3 F2 SERPINE1
20 lipid pneumonia 10.3 ARG1 CRP
21 intracranial sinus thrombosis 10.3 F3 SERPINC1
22 heparin-induced thrombocytopenia 10.3 F3 SERPINC1
23 meningococcemia 10.3 SERPINC1 SERPINE1
24 buerger disease 10.3 F2 SERPINE1
25 cerebral sinovenous thrombosis 10.3 F2 F3
26 xanthogranulomatous pyelonephritis 10.3 CRP LYZ
27 posterior myocardial infarction 10.3 PCLAF SERPINC1
28 von willebrand disease, type 1 10.3 F2 F3
29 qualitative platelet defect 10.3 F2 F3
30 pyelitis 10.3 CRP LYZ
31 dysfibrinogenemia 10.3 F2 SERPINC1
32 alcohol-related birth defect 10.3 F2 F3
33 renal tuberculosis 10.3 CRP LYZ
34 hantavirus pulmonary syndrome 10.3 F2 F3
35 intracranial thrombosis 10.3 F3 SERPINC1
36 splenic disease 10.3 F2 F3
37 factor xii deficiency 10.3 F3 SERPINC1
38 factor v deficiency 10.2 F2 F3
39 placental abruption 10.2 F2 SERPINC1
40 legg-calve-perthes disease 10.2 SERPINC1 SERPINE1
41 arteritic anterior ischemic optic neuropathy 10.2 CRP F2
42 squamous cell papilloma 10.2 F2 F3
43 multicentric castleman disease 10.2 CRP F3
44 ischemic bone disease 10.2 F2 SERPINE1
45 catastrophic antiphospholipid syndrome 10.2 F3 SERPINE1
46 hemophilia 10.2 F2 F3
47 basilar artery occlusion 10.2 F2 PLG
48 pulmonary immaturity 10.2 F3 SERPINC1
49 carotid artery thrombosis 10.2 F3 SERPINE1
50 ischemic optic neuropathy 10.2 F2 SERPINC1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 F2 SERPINC1 F3 SERPINE1 LYZ PCLAF
2 homeostasis/metabolism MP:0005376 9.97 CRP RBMS1 F2 SERPINC1 F3 SERPINE1
3 cardiovascular system MP:0005385 9.95 PLG CRP F2 SERPINC1 F3 SERPINE1
4 immune system MP:0005387 9.91 CRP F2 SERPINC1 F3 SERPINE1 LYZ
5 mortality/aging MP:0010768 9.56 ARG1 PLG RBMS1 F2 SERPINC1 F3
6 liver/biliary system MP:0005370 9.55 ARG1 PLG SERPINC1 SERPINE1 LYZ
7 respiratory system MP:0005388 9.02 PLG F2 F3 SERPINE1 LYZ

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Arginine Vasopressin Phase 4
4 Botulinum Toxins Phase 4
5 Botulinum Toxins, Type A Phase 4
6 Cholinergic Agents Phase 4
7 Neuromuscular Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 onabotulinumtoxinA Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Vasopressins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

38
Skin, Bone, Bone Marrow

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(show top 50) (show all 53)
# Title Authors Year
1
Blue toe syndrome as a first sign of systemic sclerosis. ( 29305361 )
2018
2
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
3
Blue toe syndrome, ischemic pain treated with digital block. ( 25605677 )
2015
4
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. ( 24861307 )
2014
5
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. ( 25534490 )
2014
6
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. ( 24810697 )
2014
7
Blue toe syndrome--reply. ( 24810698 )
2014
8
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. ( 26877940 )
2013
9
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. ( 24426603 )
2013
10
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. ( 23764710 )
2013
11
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. ( 22983548 )
2012
12
Blue toe syndrome and sunitinib. ( 21136131 )
2011
13
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. ( 21571496 )
2011
14
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. ( 20609674 )
2010
15
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. ( 23074585 )
2010
16
Blue toe syndrome as a clue to the underlying cause of acute renal failure. ( 25949485 )
2010
17
Blue toe syndrome. ( 17906493 )
2007
18
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. ( 16520732 )
2006
19
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. ( 16874430 )
2006
20
Blue toe syndrome: a rare complication of acute pancreatitis. ( 12555011 )
2003
21
Case report: Blue toe syndrome caused by a true crural aneurysm. ( 12813416 )
2003
22
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. ( 12376800 )
2002
23
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. ( 12152242 )
2002
24
Angioplasty with stenting is effective in treating blue toe syndrome. ( 11951102 )
2002
25
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. ( 11341514 )
2001
26
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. ( 10834489 )
2000
27
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
28
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. ( 10498409 )
1999
29
Blue toe syndrome after initiation of low-dose oral anticoagulation. ( 9620888 )
1998
30
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. ( 9044465 )
1997
31
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. ( 8943451 )
1996
32
Evaluation and management of cholesterol embolization and the blue toe syndrome. ( 8889381 )
1996
33
Blue toe syndrome from a "coral reef" aorta. ( 8746834 )
1995
34
Additional causes of the blue toe syndrome. ( 7791402 )
1995
35
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. ( 8284757 )
1994
36
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. ( 7963875 )
1994
37
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. ( 8214780 )
1993
38
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. ( 1535174 )
1992
39
Blue toe syndrome. Causes and management. ( 1444678 )
1992
40
Blue toe syndrome. ( 1747352 )
1991
41
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. ( 2240906 )
1990
42
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. ( 2324190 )
1990
43
Blue toe syndrome: treatment with percutaneous atherectomy. ( 2813788 )
1989
44
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. ( 2962224 )
1988
45
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. ( 3246660 )
1988
46
Blue toe syndrome. ( 3716963 )
1986
47
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. ( 3512857 )
1986
48
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. ( 6507759 )
1984
49
Blue toe syndrome. A case presentation. ( 6655197 )
1983
50
Blue toe syndrome--a warning sign of unsuspected vascular injury. ( 6221428 )
1983

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 ARG1 CRP F2 F3 LYZ PLG
2 extracellular region GO:0005576 9.56 ARG1 CRP F2 F3 LYZ PLG
3 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
4 extracellular space GO:0005615 9.23 ARG1 CRP F2 F3 LYZ PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 LYZ PLG SERPINC1
2 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
3 acute-phase response GO:0006953 9.43 CRP F2
4 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
5 positive regulation of blood coagulation GO:0030194 9.37 F2 SERPINE1
6 fibrinolysis GO:0042730 9.33 F2 PLG SERPINE1
7 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINE1
8 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
2 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINE1

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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