MCID: BLT003
MIFTS: 31

Blue Toe Syndrome malady

Cardiovascular diseases category

Aliases & Classifications for Blue Toe Syndrome

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Aliases & Descriptions for Blue Toe Syndrome:

Name: Blue Toe Syndrome 10 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:14121
MeSH36 D018438

Summaries for Blue Toe Syndrome

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Wikipedia:68 Blue toe syndrome is a situation of atherothrombotic microembolism, causing transient focal ischaemia,... more...

MalaCards based summary: Blue Toe Syndrome is related to cholesterol embolism and chondrodysplasia punctata. An important gene associated with Blue Toe Syndrome is JAK2 (Janus Kinase 2), and among its related pathways are Development_Thrombopoetin signaling via JAK-STAT pathway and Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include bone, skin and bone marrow, and related mouse phenotypes are hematopoietic system and mortality/aging.

Related Diseases for Blue Toe Syndrome

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Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1cholesterol embolism10.4
2chondrodysplasia punctata10.3ARG1, JAK2
3adamantinous craniopharyngioma10.3F2, JAK2
4retinoblastoma10.3
5aneurysm10.3
6spinocerebellar atrophy10.3F2, SERPINC1
7hypoprothrombinemia10.3F2, SERPINC1
8aggressive systemic mastocytosis10.3F2, SERPINC1
9maxillary sinus cholesteatoma10.3F2, SERPINC1
10coronary artery vasospasm10.2CRP, F2
11sesame syndrome10.2F2, SERPINC1
12acute myocarditis10.2CRP, F2
13conversion disorder10.2F2, SERPINC1
14abnormal pupillary function10.2CRP, F2
15hyperlipoproteinemia type iv10.2CRP, F2
16rocky mountain spotted fever10.2CRP, SERPINC1
17bolivian hemorrhagic fever10.2SERPINC1, SERPINE1
18liver failure acute infantile10.2F2, SERPINE1
19malignant cornea melanoma10.2CRP, LYZ
20intracranial structure hemangioma10.2F3, SERPINC1
21hepatic cystic hamartoma10.2F3, SERPINC1
22diffuse idiopathic skeletal hyperostosis10.2F2, F3
23pyometritis10.2CRP, F2
24malignant granular cell myoblastoma10.2F2, SERPINC1
25barrett's adenocarcinoma10.2F2, F3
26tall stature - scoliosis - macrodactyly of the great toes10.2F2, F3
27thyroid angiosarcoma10.2KIAA0101, SERPINC1
28von willebrand disease, type 110.2F2, F3
29appendicitis10.2F2, SERPINC1
30equatorial staphyloma10.2F2, F3
31pyelonephritis10.2CRP, LYZ
32meningoencephalocele10.2SERPINC1, SERPINE1
33suppurative uveitis10.2F2, F3
34budd-chiari syndrome10.2F2, JAK2, SERPINC1
35oropharyngeal anthrax10.2KIAA0101, LYZ
36cerebral neuroblastoma10.2F2, F3
37protein c deficiency10.2F2, JAK2, SERPINC1
38dic in newborn10.2F2, F3
39hepatoblastoma10.2F2, JAK2, SERPINC1
40bladder hepatoid adenocarcinoma10.2F3, SERPINC1
41homocystinuria due to cbs deficiency10.2CRP, F2
42islet cell tumor10.2F2, SERPINC1
43anterior scleritis10.2F2, F3
44legg-calve-perthes disease10.2SERPINC1, SERPINE1
45splenic manifestation of leukemia10.2F2, F3
46cerebellar vermis medulloblastoma10.2CRP, F2
47dysgnathia complex10.2F2, SERPINC1
48factor xi deficiency, autosomal recessive10.2F2, F3
49skeletal muscle regeneration10.1F2, F3
50factor xii deficiency10.1F3, SERPINC1

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to blue toe syndrome

Symptoms for Blue Toe Syndrome

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Drugs & Therapeutics for Blue Toe Syndrome

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Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VasopressinsPhase 4159
2Botulinum Toxins, Type APhase 4561
3Botulinum ToxinsPhase 4590
4Arginine VasopressinPhase 4163

Interventional clinical trials:

idNameStatusNCT IDPhase
1Botulinum Toxin A for Treatment of Catocholamine Induced Finger NecrosisRecruitingNCT01500668Phase 4

Search NIH Clinical Center for Blue Toe Syndrome


Cochrane evidence based reviews: Blue Toe Syndrome

Genetic Tests for Blue Toe Syndrome

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Anatomical Context for Blue Toe Syndrome

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MalaCards organs/tissues related to Blue Toe Syndrome:

33
Bone, Skin, Bone marrow

Animal Models for Blue Toe Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Blue Toe Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.1ARG1, F2, F3, JAK2, KIAA0101, PLG
2MP:00107686.9ARG1, F2, F3, JAK2, PLG, RBMS1
3MP:00053876.4ARG1, CRP, F2, F3, JAK2, KIAA0101
4MP:00053766.3ARG1, CRP, F2, F3, JAK2, PLG

Publications for Blue Toe Syndrome

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Articles related to Blue Toe Syndrome:

(show all 50)
idTitleAuthorsYear
1
Blue toe syndrome, ischemic pain treated with digital block. (25605677)
2015
2
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. (24861307)
2014
3
Blue toe syndrome--reply. (24810698)
2014
4
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. (24810697)
2014
5
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. (25534490)
2014
6
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. (23764710)
2013
7
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. (24426603)
2013
8
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. (22983548)
2012
9
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. (21571496)
2011
10
Blue toe syndrome and sunitinib. (21136131)
2011
11
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. (23074585)
2010
12
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. (20609674)
2010
13
Blue toe syndrome as a clue to the underlying cause of acute renal failure. (25949485)
2010
14
Blue toe syndrome. (17906493)
2007
15
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. (16520732)
2006
16
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. (16874430)
2006
17
Case report: Blue toe syndrome caused by a true crural aneurysm. (12813416)
2003
18
Blue toe syndrome: a rare complication of acute pancreatitis. (12555011)
2003
19
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. (12376800)
2002
20
Angioplasty with stenting is effective in treating blue toe syndrome. (11951102)
2002
21
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. (12152242)
2002
22
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. (11341514)
2001
23
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. (11399611)
2000
24
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. (10834489)
2000
25
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. (10498409)
1999
26
Blue toe syndrome after initiation of low-dose oral anticoagulation. (9620888)
1998
27
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. (9044465)
1997
28
Evaluation and management of cholesterol embolization and the blue toe syndrome. (8889381)
1996
29
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. (8943451)
1996
30
Additional causes of the blue toe syndrome. (7791402)
1995
31
Blue toe syndrome from a "coral reef" aorta. (8746834)
1995
32
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. (7963875)
1994
33
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. (8284757)
1994
34
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. (8214780)
1993
35
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. (1535174)
1992
36
Blue toe syndrome. Causes and management. (1444678)
1992
37
Blue toe syndrome. (1747352)
1991
38
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. (2240906)
1990
39
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. (2324190)
1990
40
Blue toe syndrome: treatment with percutaneous atherectomy. (2813788)
1989
41
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. (2962224)
1988
42
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. (3246660)
1988
43
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. (3512857)
1986
44
Blue toe syndrome. (3716963)
1986
45
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. (6507759)
1984
46
Blue toe syndrome--a warning sign of unsuspected vascular injury. (6221428)
1983
47
Blue toe syndrome. A case presentation. (6655197)
1983
48
Experience with the Blue Toe Syndrome. (7076462)
1982
49
Blue toe syndrome. (7108117)
1982
50
Bilateral blue toe syndrome. A case report. (7351752)
1980

Variations for Blue Toe Syndrome

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Expression for genes affiliated with Blue Toe Syndrome

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Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for genes affiliated with Blue Toe Syndrome

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GO Terms for genes affiliated with Blue Toe Syndrome

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Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.8F2, PLG, SERPINC1
2extracellular matrixGO:00310129.2F2, F3, SERPINE1
3extracellular regionGO:00055767.8CRP, F2, LYZ, PLG, SERPINC1, SERPINE1
4extracellular exosomeGO:00700627.1ARG1, CRP, F2, F3, LYZ, PLG
5extracellular spaceGO:00056156.8ARG1, CRP, F2, F3, LYZ, PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to dexamethasone stimulusGO:007154910.2ARG1, JAK2
2acute-phase responseGO:000695310.2CRP, F2
3positive regulation of blood coagulationGO:003019410.1F2, SERPINE1
4cellular response to lipopolysaccharideGO:00712229.8ARG1, JAK2, SERPINE1
5response to woundingGO:00096119.8ARG1, F2, F3
6response to lipopolysaccharideGO:00324969.7ARG1, F3, JAK2
7fibrinolysisGO:00427309.6F2, PLG, SERPINE1
8negative regulation of fibrinolysisGO:00519189.6F2, PLG, SERPINE1
9platelet activationGO:00301689.1F2, PLG, SERPINE1
10blood coagulationGO:00075967.6F2, F3, JAK2, PLG, SERPINC1, SERPINE1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.5F3, SERPINC1, SERPINE1
2receptor bindingGO:00051028.8F2, JAK2, PLG, SERPINE1

Sources for Blue Toe Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet