MCID: BLT003
MIFTS: 35

Blue Toe Syndrome

Categories: Cardiovascular diseases

Aliases & Classifications for Blue Toe Syndrome

MalaCards integrated aliases for Blue Toe Syndrome:

Name: Blue Toe Syndrome 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14121
MeSH 42 D018438
UMLS 69 C0242645

Summaries for Blue Toe Syndrome

MalaCards based summary : Blue Toe Syndrome is related to cholesterol embolism and syncope. An important gene associated with Blue Toe Syndrome is ARG1 (Arginase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient... more...

Related Diseases for Blue Toe Syndrome

Diseases related to Blue Toe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 cholesterol embolism 11.7
2 syncope 10.7 F2 SERPINC1
3 superior limbic keratoconjunctivitis 10.7 F2 SERPINC1
4 follicular adenoma 10.7 F2 SERPINC1
5 hiv-1 10.7 F2 SERPINC1
6 glutathioninuria 10.6 F2 SERPINC1
7 pilomyxoid astrocytoma 10.6 F2 SERPINC1
8 angelucci's syndrome 10.6 F2 SERPINC1
9 chronic fungal otitis externa 10.6 CRP F2
10 rocky mountain spotted fever 10.6 CRP SERPINC1
11 childhood brain stem glioma 10.6 F2 SERPINC1
12 synostosis 10.6 CRP F2
13 stoll alembik finck syndrome 10.6 SERPINC1 SERPINE1
14 angular blepharoconjunctivitis 10.6 F2 SERPINC1
15 venezuelan hemorrhagic fever 10.6 SERPINC1 SERPINE1
16 lockwood feingold syndrome 10.5 F2 SERPINE1
17 pleomorphic rhabdomyosarcoma 10.5 ARG1 CRP
18 alternating exotropia 10.5 CRP LYZ
19 sagittal sinus thrombosis 10.5 F3 SERPINC1
20 hereditary amyloidosis 10.5 F3 SERPINC1
21 mental retardation dysmorphism hypogonadism diabetes 10.5 SERPINC1 SERPINE1
22 homologous wasting disease 10.5 CRP F2
23 dyskeratosis congenita autosomal recessive 10.5 F2 SERPINC1
24 ulcerative stomatitis 10.5 F2 SERPINC1
25 elejalde disease 10.5 F2 SERPINE1
26 inferior myocardial infarction 10.5 PCLAF SERPINC1
27 glycogen storage disease viii 10.5 CRP LYZ
28 eustachian tube disease 10.5 CRP LYZ
29 46,xy ovotesticular disorder of sex development 10.5 F2 F3
30 von willibrand disease, type 3 10.5 F2 F3
31 female breast cancer 10.5 F2 F3
32 femoral neuropathy 10.5 F3 SERPINC1
33 sporotrichosis 10.4 F2 F3
34 chronic inflammatory demyelinating polyneuritis 10.4 F2 F3
35 stickler sydrome, type i, nonsyndromic ocular 10.4 SERPINC1 SERPINE1
36 facioscapulohumeral muscular dystrophy 1 10.4 F2 F3
37 hepatocellular adenoma 10.4 CRP F2
38 angioedema, hereditary, type iii 10.4 F3 SERPINC1
39 factor v deficiency 10.4 F2 F3
40 joint disorders 10.4 F2 SERPINC1
41 bernard-soulier syndrome, type a2 10.4 F2 SERPINC1
42 bone resorption disease 10.4 F2 SERPINE1
43 red color blindness 10.4 F2 F3
44 coronary stenosis 10.4 F3 SERPINC1
45 hyperphenylalaninemia 10.4 F2 F3
46 leukorrhea 10.3 F2 SERPINC1
47 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.3 CRP F3
48 cavernous lymphangioma 10.3 F3 SERPINE1
49 optic nerve neoplasm 10.3 F3 SERPINE1
50 coccidioidomycosis 10.3 F2 PLG

Graphical network of the top 20 diseases related to Blue Toe Syndrome:



Diseases related to Blue Toe Syndrome

Symptoms & Phenotypes for Blue Toe Syndrome

MGI Mouse Phenotypes related to Blue Toe Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ARG1 F2 F3 LYZ PCLAF PLG
2 homeostasis/metabolism MP:0005376 9.97 ARG1 CRP F2 F3 LYZ PLG
3 cardiovascular system MP:0005385 9.95 F2 F3 LYZ PLG SERPINC1 SERPINE1
4 immune system MP:0005387 9.91 ARG1 CRP F2 F3 LYZ PCLAF
5 mortality/aging MP:0010768 9.56 ARG1 F2 F3 LYZ PLG RBMS1
6 liver/biliary system MP:0005370 9.55 ARG1 LYZ PLG SERPINC1 SERPINE1
7 respiratory system MP:0005388 9.02 F2 F3 LYZ PLG SERPINE1

Drugs & Therapeutics for Blue Toe Syndrome

Drugs for Blue Toe Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Arginine Vasopressin Phase 4
4 Botulinum Toxins Phase 4
5 Botulinum Toxins, Type A Phase 4
6 Cholinergic Agents Phase 4
7 Neuromuscular Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 onabotulinumtoxinA Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Vasopressins Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4 Botox;Placebo

Search NIH Clinical Center for Blue Toe Syndrome

Cochrane evidence based reviews: blue toe syndrome

Genetic Tests for Blue Toe Syndrome

Anatomical Context for Blue Toe Syndrome

MalaCards organs/tissues related to Blue Toe Syndrome:

39
Skin, Bone, Bone Marrow

Publications for Blue Toe Syndrome

Articles related to Blue Toe Syndrome:

(show top 50) (show all 52)
id Title Authors Year
1
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
2
Blue toe syndrome, ischemic pain treated with digital block. ( 25605677 )
2015
3
A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome. ( 25534490 )
2014
4
Blue toe syndrome: a complication of intra-arterial technique, not intra-arterial chemotherapy for retinoblastoma. ( 24810697 )
2014
5
Skin lesions simulating blue toe syndrome caused by prolonged contact with a millipede. ( 24861307 )
2014
6
Blue toe syndrome--reply. ( 24810698 )
2014
7
Coil embolization of persistent sciatic artery pseudoaneurysm presenting as blue toe syndrome, a rare case. ( 24426603 )
2013
8
Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma. ( 23764710 )
2013
9
Blue toe syndrome treated with sympathectomy in a patient with acute renal failure caused by cholesterol embolization. ( 26877940 )
2013
10
Compression of the dorsalis pedis artery: a novel cause of blue toe syndrome. ( 22983548 )
2012
11
Epithelioid hemangioendothelioma as a rare cause of blue toe syndrome. ( 21571496 )
2011
12
Blue toe syndrome and sunitinib. ( 21136131 )
2011
13
Blue toe syndrome as a clue to the underlying cause of acute renal failure. ( 25949485 )
2010
14
Locked-in Syndrome and Blue Toe Syndrome Caused by Cardiopulmonary Bypass. ( 23074585 )
2010
15
Isolated blue toe syndrome as the initial sign of Wegener granulomatosis. ( 20609674 )
2010
16
Blue toe syndrome. ( 17906493 )
2007
17
Renal failure associated with blue toe syndrome: effective treatment with intravenous prostaglandin E-1. ( 16874430 )
2006
18
Spontaneous dissection of the popliteal artery in a young man. A rare cause of the blue toe syndrome. ( 16520732 )
2006
19
Case report: Blue toe syndrome caused by a true crural aneurysm. ( 12813416 )
2003
20
Blue toe syndrome: a rare complication of acute pancreatitis. ( 12555011 )
2003
21
A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies. ( 12152242 )
2002
22
Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a case. ( 12376800 )
2002
23
Angioplasty with stenting is effective in treating blue toe syndrome. ( 11951102 )
2002
24
The blue toe syndrome during oral anticoagulant therapy with acenocoumarol. ( 11341514 )
2001
25
Blue toe syndrome: treatment with intra-arterial stents and review of therapies. ( 10834489 )
2000
26
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
27
Special exhibit for the SCVIR Annual Meeting Film Panel Session: diagnosis and discussion of cases 5-8. Society of Cardiovascular & Interventional Radiology. Case 6. Blue-toe syndrome secondary to embolization from a complex right common iliac artery plaque containing fresh thrombus material. ( 10498409 )
1999
28
Blue toe syndrome after initiation of low-dose oral anticoagulation. ( 9620888 )
1998
29
Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia. ( 9044465 )
1997
30
Evaluation and management of cholesterol embolization and the blue toe syndrome. ( 8889381 )
1996
31
Transesophageal echocardiographic findings in blue toe syndrome exacerbated by anticoagulation. ( 8943451 )
1996
32
Blue toe syndrome from a "coral reef" aorta. ( 8746834 )
1995
33
Additional causes of the blue toe syndrome. ( 7791402 )
1995
34
Femoral artery hypoplasia and persistent sciatic artery with blue toe syndrome: a case report, histologic analysis and review of the literature. ( 7963875 )
1994
35
External iliac ligation and axillary-bifemoral bypass for blue toe syndrome. ( 8284757 )
1994
36
Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report. ( 8214780 )
1993
37
Atherectomy of the distal aorta using a "kissing-balloon" technique for the treatment of blue toe syndrome. ( 1535174 )
1992
38
Blue toe syndrome. Causes and management. ( 1444678 )
1992
39
Blue toe syndrome. ( 1747352 )
1991
40
Corticosteroid-associated blue toe syndrome: role of antiphospholipid antibodies. ( 2240906 )
1990
41
Atherothrombotic microembolism of the lower extremities (the blue toe syndrome) from atherosclerotic non-aneurysmal aortic plaques. ( 2324190 )
1990
42
Blue toe syndrome: treatment with percutaneous atherectomy. ( 2813788 )
1989
43
Blue toe syndrome: treatment with anticoagulants and delayed percutaneous transluminal angioplasty. ( 2962224 )
1988
44
Digital arterial embolism-true blue toe syndrome. A histopathologic analysis. ( 3246660 )
1988
45
Blue toe syndrome. ( 3716963 )
1986
46
The blue toe syndrome: hemodynamics and therapeutic correlates of outcome. ( 3512857 )
1986
47
Dilemmas in dealing with the blue toe syndrome: aortic versus peripheral source. ( 6507759 )
1984
48
Blue toe syndrome. A case presentation. ( 6655197 )
1983
49
Blue toe syndrome--a warning sign of unsuspected vascular injury. ( 6221428 )
1983
50
Experience with the Blue Toe Syndrome. ( 7076462 )
1982

Variations for Blue Toe Syndrome

Expression for Blue Toe Syndrome

Search GEO for disease gene expression data for Blue Toe Syndrome.

Pathways for Blue Toe Syndrome

GO Terms for Blue Toe Syndrome

Cellular components related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 ARG1 CRP F2 F3 LYZ PLG
2 extracellular region GO:0005576 9.56 ARG1 CRP F2 F3 LYZ PLG
3 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
4 extracellular space GO:0005615 9.23 ARG1 CRP F2 F3 LYZ PLG

Biological processes related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.62 F2 LYZ PLG SERPINC1
2 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
3 acute-phase response GO:0006953 9.43 CRP F2
4 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
5 positive regulation of blood coagulation GO:0030194 9.37 F2 SERPINE1
6 fibrinolysis GO:0042730 9.33 F2 PLG SERPINE1
7 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINE1
8 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Blue Toe Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
2 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINE1

Sources for Blue Toe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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