MCID: BMP001
MIFTS: 13

Bmpr1a-Related Juvenile Polyposis malady

Summaries for Bmpr1a-Related Juvenile Polyposis

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32MalaCards
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MalaCards: Bmpr1a-Related Juvenile Polyposis is related to familial adenomatous polyposis and bannayan-riley-ruvalcaba syndrome. An important gene associated with Bmpr1a-Related Juvenile Polyposis is BMPR1A (bone morphogenetic protein receptor, type IA), and among its related pathways are Hippo signaling pathway and Integrated Breast Cancer Pathway. The compound threonine have been mentioned in the context of this disorder.

Aliases & Classifications for Bmpr1a-Related Juvenile Polyposis

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20GeneTests
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Aliases & Descriptions:

bmpr1a-related juvenile polyposis 20


Related Diseases for Bmpr1a-Related Juvenile Polyposis

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17GeneCards, 18GeneDecks
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Diseases in the Juvenile Polyposis Syndrome family:

Smad4-Related Juvenile Polyposis bmpr1a-related juvenile polyposis
Juvenile Polyposis of Infancy

Diseases related to Bmpr1a-Related Juvenile Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1familial adenomatous polyposis10.0SMAD4
2bannayan-riley-ruvalcaba syndrome10.0BMPR1A
3peutz-jeghers syndrome10.0BMPR1A
4juvenile polyposis syndrome10.0SMAD4, BMPR1A
5cowden disease10.0BMPR1A, SMAD4
6hereditary hemorrhagic telangiectasia10.0SMAD4, BMPR1A

Graphical network of diseases related to Bmpr1a-Related Juvenile Polyposis:



Diseases related to bmpr1a-related juvenile polyposis

Clinical Features for Bmpr1a-Related Juvenile Polyposis

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Drugs & Therapeutics for Bmpr1a-Related Juvenile Polyposis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bmpr1a-Related Juvenile Polyposis

Drug clinical trials:

Search ClinicalTrials for Bmpr1a-Related Juvenile Polyposis

Search NIH Clinical Center for Bmpr1a-Related Juvenile Polyposis

Search CenterWatch for Bmpr1a-Related Juvenile Polyposis

Genetic Tests for Bmpr1a-Related Juvenile Polyposis

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20GeneTests
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Genetic tests related to Bmpr1a-Related Juvenile Polyposis:

id Genetic test Affiliating Genes
1 Bmpr1a-Related Juvenile Polyposis20 BMPR1A

Anatomical Context for Bmpr1a-Related Juvenile Polyposis

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Animal Models for Bmpr1a-Related Juvenile Polyposis or affiliated genes

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Publications for Bmpr1a-Related Juvenile Polyposis

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Genetic Variations for Bmpr1a-Related Juvenile Polyposis

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Expression for genes affiliated with Bmpr1a-Related Juvenile Polyposis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bmpr1a-Related Juvenile Polyposis

Search GEO for disease gene expression data for Bmpr1a-Related Juvenile Polyposis.

Pathways for genes affiliated with Bmpr1a-Related Juvenile Polyposis

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29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Bmpr1a-Related Juvenile Polyposis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SMAD4, BMPR1A
29.1SMAD4, BMPR1A
39.1BMPR1A, SMAD4
49.1SMAD4, BMPR1A
5
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9.1SMAD4, BMPR1A

Compounds for genes affiliated with Bmpr1a-Related Juvenile Polyposis

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44Novoseek
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Compounds related to Bmpr1a-Related Juvenile Polyposis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1threonine449.1SMAD4, BMPR1A

GO Terms for genes affiliated with Bmpr1a-Related Juvenile Polyposis

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16Gene Ontology
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Biological processes related to Bmpr1a-Related Juvenile Polyposis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of SMAD protein import into nucleusGO:0603919.3SMAD4, BMPR1A
2positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.3SMAD4, BMPR1A
3developmental growthGO:0485899.2SMAD4, BMPR1A
4BMP signaling pathwayGO:0305099.2SMAD4, BMPR1A
5palate developmentGO:0600219.1BMPR1A, SMAD4
6positive regulation of transcription, DNA-dependentGO:0458939.1SMAD4, BMPR1A
7transforming growth factor beta receptor signaling pathwayGO:0071799.0SMAD4, BMPR1A
8in utero embryonic developmentGO:0017018.8SMAD4, BMPR1A

Molecular functions related to Bmpr1a-Related Juvenile Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1SMAD4, BMPR1A

Products for genes affiliated with Bmpr1a-Related Juvenile Polyposis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bmpr1a-Related Juvenile Polyposis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet