MCID: BDY001
MIFTS: 43

Body Dysmorphic Disorder

Categories: Mental diseases

Aliases & Classifications for Body Dysmorphic Disorder

MalaCards integrated aliases for Body Dysmorphic Disorder:

Name: Body Dysmorphic Disorder 12 72 36 14
Dysmorphophobia 12 72
Body Dysmorphic Disorders 69
Dysmorphic Syndrome 12
Body Dysmorphia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060163
KEGG 36 H01447
UMLS 69 C0005887

Summaries for Body Dysmorphic Disorder

Disease Ontology : 12 A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).

MalaCards based summary : Body Dysmorphic Disorder, also known as dysmorphophobia, is related to hypoparathyroidism-retardation-dysmorphism syndrome and birk-barel mental retardation dysmorphism syndrome. An important gene associated with Body Dysmorphic Disorder is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Serotonergic synapse and Metabolism of water-soluble vitamins and cofactors. The drugs Piracetam and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin.

Wikipedia : 72 Body dysmorphic disorder (BDD), occasionally still called dysmorphophobia, is a mental disorder... more...

Related Diseases for Body Dysmorphic Disorder

Diseases related to Body Dysmorphic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 hypoparathyroidism-retardation-dysmorphism syndrome 12.2
2 birk-barel mental retardation dysmorphism syndrome 12.2
3 macrocephaly, macrosomia, and facial dysmorphism syndrome 12.1
4 hypoparathyroidism-intellectual disability-dysmorphism syndrome 12.1
5 choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome 11.9
6 intellectual disability-severe speech delay-mild dysmorphism syndrome 11.9
7 night blindness-skeletal anomalies-dysmorphism syndrome 11.7
8 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.7
9 intellectual disability-expressive aphasia-facial dysmorphism syndrome 11.7
10 congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome 11.7
11 aids dysmorphic syndrome 11.7
12 thin ribs-tubular bones-dysmorphism syndrome 11.7
13 short stature-deafness-neutrophil dysfunction-dysmorphism syndrome 11.7
14 intellectual disability-obesity-brain malformations-facial dysmorphism syndrome 11.7
15 intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome 11.7
16 microcephaly-short stature-intellectual disability-facial dysmorphism syndrome 11.7
17 x-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome 11.7
18 osteopenia-myopia-hearing loss-intellectual disability-facial dysmorphism syndrome 11.7
19 x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 11.7
20 arachnodactyly - intellectual disability - dysmorphism 11.3
21 kcnk9 imprinting syndrome 10.9
22 culler-jones syndrome 10.8
23 epileptic encephalopathy, early infantile, 23 10.8
24 short stature, hearing loss, retinitis pigmentosa, and distinctive facies 10.8
25 fibromatosis, gingival, with distinctive facies 10.7
26 hirschsprung disease with hypoplastic nails and dysmorphic facial features 10.7
27 spinocerebellar ataxia with dysmorphism 10.7
28 cubitus valgus with mental retardation and unusual facies 10.7
29 fryns macrocephaly 10.7
30 dislocation of hip, congenital, with hyperextensibility of fingers and facial dysmorphism 10.7
31 spondylometaphyseal dysplasia with bowed forearms and facial dysmorphism 10.7
32 burn-mckeown syndrome 10.7
33 mental retardation with language impairment and with or without autistic features 10.7
34 beaulieu-boycott-innes syndrome 10.7
35 steel syndrome 10.7
36 mental retardation, autosomal recessive 39 10.7
37 mental retardation, autosomal dominant 23 10.7
38 xia-gibbs syndrome 10.7
39 tatton-brown-rahman syndrome 10.7
40 mental retardation, autosomal dominant 36 10.7
41 klippel-feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism 10.7
42 mental retardation and distinctive facial features with or without cardiac defects 10.7
43 epiphyseal dysplasia hearing loss dysmorphism 10.7
44 med13l haploinsufficiency syndrome 10.7
45 reunion island larsen syndrome 10.7
46 cono-spondylar dysplasia 10.7
47 acromegaloid facial appearance syndrome 10.6
48 brachioskeletogenital syndrome 10.6
49 atelosteogenesis, type ii 10.6
50 pfeiffer-palm-teller syndrome 10.6

Graphical network of the top 20 diseases related to Body Dysmorphic Disorder:



Diseases related to Body Dysmorphic Disorder

Symptoms & Phenotypes for Body Dysmorphic Disorder

Drugs & Therapeutics for Body Dysmorphic Disorder

Drugs for Body Dysmorphic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved, Investigational Phase 4 7491-74-9
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Norepinephrine Approved Phase 4 51-41-2 439260
4 Etiracetam Investigational Phase 4 33996-58-6
5 Anticonvulsants Phase 4
6 Neuroprotective Agents Phase 4
7 Nootropic Agents Phase 4
8 Protective Agents Phase 4,Phase 2
9 Antidepressive Agents Phase 4,Phase 3
10 Antidepressive Agents, Second-Generation Phase 4,Phase 3
11 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
14 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
15 Psychotropic Drugs Phase 4,Phase 3,Phase 2
16
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
17 Serotonin Agents Phase 4,Phase 3,Phase 2
18 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
20 Venlafaxine Hydrochloride Phase 4
21
Citalopram Approved Phase 3 59729-33-8 2771
22 Antiparkinson Agents Phase 3
23 Autonomic Agents Phase 3,Phase 2
24 Cholinergic Agents Phase 3
25 Cholinergic Antagonists Phase 3
26 Muscarinic Antagonists Phase 3
27 Parasympatholytics Phase 3
28 Peripheral Nervous System Agents Phase 3,Phase 2
29
Oxytocin Approved, Vet_approved Phase 2 50-56-6 53477758 439302
30
Ondansetron Approved Phase 2 99614-02-5 4595
31
Lactitol Investigational Phase 2 585-86-4 3871
32 Hormones Phase 2
33 Oxytocics Phase 2
34 Antioxidants Phase 2
35 Central Nervous System Depressants Phase 2
36 Anti-Anxiety Agents Phase 2
37 Antiemetics Phase 2
38 Antipruritics Phase 2
39 Antipsychotic Agents Phase 2
40 Dermatologic Agents Phase 2
41 Gastrointestinal Agents Phase 2
42 Serotonin Antagonists Phase 2
43 Tranquilizing Agents Phase 2
44 Milk Thistle Nutraceutical Phase 2
45 silymarin Nutraceutical Phase 2
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Memantine Approved, Investigational 19982-08-2 4054
48
Cocaine Approved, Illicit 50-36-2 446220 5760
49
Cycloserine Approved Early Phase 1 68-41-7 6234 401
50
Diprenorphine Illicit, Vet_approved 14357-78-9

Interventional clinical trials:

(show all 30)

# Name Status NCT ID Phase Drugs
1 Effectiveness of Levetiracetam in the Treatment of Body Dysmorphic Disorder Completed NCT00265109 Phase 4 Levetiracetam
2 Fluoxetine in Pediatric Body Dysmorphic Disorder Completed NCT00245635 Phase 4 Fluoxetine;Placebo
3 CBT as an Adjunct to SRIs in the Treatment of BDD Terminated NCT00211809 Phase 4 Venlafaxine
4 Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder Completed NCT00149799 Phase 3 Escitalopram;Placebo
5 Study of Patients With Body Image Issues Treated With 2 Different Behavioral Interventions Unknown status NCT01316627 Phase 2
6 Oxytocin Administration in BDD and OCD Completed NCT02671266 Phase 2 Oxytocin;Placebo
7 Milk Thistle in Body Dysmorphic Disorder Recruiting NCT02843451 Phase 2 Milk Thistle;Placebo
8 Efficacy and Safety Study of Low-Dose Ondansetron For Adjunctive Therapy In Adult Patients With Obsessive-Compulsive Disorder Terminated NCT01275248 Phase 2 Ondansetron;Placebo
9 Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder Unknown status NCT01453439
10 Attentional Bias in Body Dysmorphic Disorder Completed NCT01398904
11 Internet Cognitive Behavior Therapy (CBT) for Body Dysmorphic Disorder (BDD) Completed NCT01850433
12 Treatment Study Investigating New Cognitive Behavioral Therapy Treatment Manual for Body Dysmorphic Disorder Completed NCT00106223
13 Cognitive-Behavioral Therapy for Pediatric Body Dysmorphic Disorder Completed NCT01002326
14 Internet Delivered CBT for Body Dysmorphic Disorder Completed NCT02010619
15 An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder Completed NCT01038128 Memantine
16 Cognitive Behaviour Therapy (CBT) for Body Dysmorphic Disorder (BDD) Completed NCT00871143
17 Escitalopram Neuroimaging Supplement Completed NCT01398865
18 Assessment of Body Image in Patients With Rheumatoid Arthritis Completed NCT00832910
19 Effectiveness of Dance on Patients With Fibromyalgia Completed NCT00961805
20 Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA) Completed NCT02381639
21 Cortical Excitability in Obsessive-Compulsive and Related Disorders Completed NCT00029068
22 Smartphone-Administered App Treatment for Adults With Body Dysmorphic Disorder Recruiting NCT03221738
23 Contribution of a Virtual Reality Program in the Treatment of Dysmorphophobia for Adolescent Female With Anorexia Nervosa Recruiting NCT03426930
24 Body Image Disorder in Anorexia Nervosa and Virtual Reality Recruiting NCT03118921
25 Brain Correlates of Self-Focused Processing Recruiting NCT02808702
26 White Light Scanning to Aid Body Contouring: A Pilot Project Recruiting NCT01093950
27 Evaluation of Brain Opioid Receptor Activity in Anorexia Nervosa : a PET [11C]Diprenorphine Study Recruiting NCT02524301 Positron Emission Tomography using [11C]diprenorphine
28 Interpretation Bias Modification for Body Dysmorphic Disorder Active, not recruiting NCT02635152
29 D-Cycloserine Augmentation of Behavior Therapy for Individuals With Body Dysmorphic Disorder Active, not recruiting NCT00842309 Early Phase 1 d-cycloserine;Placebo
30 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672

Search NIH Clinical Center for Body Dysmorphic Disorder

Genetic Tests for Body Dysmorphic Disorder

Anatomical Context for Body Dysmorphic Disorder

MalaCards organs/tissues related to Body Dysmorphic Disorder:

38
Brain, Eye, Skin, Breast, Testes, Bone

Publications for Body Dysmorphic Disorder

Articles related to Body Dysmorphic Disorder:

(show top 50) (show all 533)
# Title Authors Year
1
The classification of body dysmorphic disorder symptoms in male and female adolescents. ( 28858657 )
2018
2
A Review of Body Dysmorphic Disorder in Aesthetic Surgery Patients and the Legal Implications. ( 28204935 )
2017
3
How individuals with body dysmorphic disorder (BDD) process their own face: a quantitative and qualitative investigation based on an eye-tracking paradigm. ( 28322616 )
2017
4
Body dysmorphic disorder: Latest neuroanatomical and neuropsychological findings. ( 29072188 )
2017
5
Recent advances in understanding and managing body dysmorphic disorder. ( 28729345 )
2017
6
Visual selective attention in body dysmorphic disorder, bulimia nervosa and healthy controls. ( 27998509 )
2017
7
Body dysmorphic disorder in the dermatology patient. ( 28511828 )
2017
8
'Not just right' experiences and incompleteness in body dysmorphic disorder. ( 27918970 )
2017
9
Body dysmorphic disorder: A serious concern for our young generation. ( 28784390 )
2017
10
The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. ( 29017915 )
2017
11
A multi-method analysis of distress tolerance in body dysmorphic disorder. ( 28826046 )
2017
12
Body dysmorphic disorder and its associated psychological and psychopathological features in an Italian community sample. ( 29069974 )
2017
13
Body Dysmorphic Disorder in Patients With Autism Spectrum Disorder: A Reflection of Increased Local Processing and Self-Focus. ( 28366095 )
2017
14
Body dysmorphic disorder in female Swedish dermatology patients. ( 28960272 )
2017
15
Body dysmorphic disorder: Diagnosis, clinical aspects and treatment strategies. ( 28611331 )
2017
16
Prevalence of body dysmorphic disorder and associated features in German adolescents: A self-report survey. ( 28482195 )
2017
17
Prevalence of Body Dysmorphic Disorder in Plastic Surgery and Dermatology Patients: A Systematic Review with Meta-Analysis. ( 28411353 )
2017
18
Evaluation of the Body Parts That Preoccupy Adolescents With Body Dysmorphic Disorder. ( 29099545 )
2017
19
Insight in body dysmorphic disorder (BDD) relative to obsessive-compulsive disorder (OCD) and psychotic disorders: Revisiting this issue in light of DSM-5. ( 28651226 )
2017
20
Sex Differences in the Presentation of Body Dysmorphic Disorder in a Community Sample of Adolescents. ( 28541768 )
2017
21
Body dysmorphic disorder: history and curiosities. ( 28220373 )
2017
22
Face and Object Perception in Body Dysmorphic Disorder versus Obsessive-Compulsive Disorder: The Mooney Faces Task. ( 28528596 )
2017
23
Neurocognitive Functioning in Young Adults with Subclinical Body Dysmorphic Disorder. ( 28367586 )
2017
24
Long-Term Outcomes of Cognitive-Behavioral Therapy for Adolescent Body Dysmorphic Disorder. ( 28577583 )
2017
25
An Aberrant Presentation of Delusional Body Dysmorphic Disorder - Importance of Early Psychiatry Liaison. ( 28479822 )
2017
26
Validation of Spanish Language Evaluation Instruments for Body Dysmorphic Disorder and the Dysmorphic Concern Construct. ( 28713311 )
2017
27
Reduced cortical thickness in body dysmorphic disorder. ( 27918913 )
2017
28
Set shifting and visuospatial organization deficits in body dysmorphic disorder. ( 29202381 )
2017
29
Patient-identified events implicated in the development of body dysmorphic disorder. ( 28285175 )
2017
30
Reduced striatal dopamine D2/3 receptor availability in Body Dysmorphic Disorder. ( 26711686 )
2016
31
Prevalence of Body Dysmorphic Disorder and Surgeon Diagnostic Accuracy in Facial Plastic and Oculoplastic Surgery Clinics. ( 27930752 )
2016
32
Prevalence and correlates of body dysmorphic disorder in a community sample of adolescents. ( 27585880 )
2016
33
Therapist guided internet based cognitive behavioural therapy for body dysmorphic disorder: single blind randomised controlled trial. ( 26837684 )
2016
34
Prevalence of Body Dysmorphic Disorder and its Association With Body Features in Female Medical Students. ( 27803720 )
2016
35
Body dysmorphic disorder in different settings: A systematic review and estimated weighted prevalence. ( 27498379 )
2016
36
Case report of body dysmorphic disorder in a suicidal patient. ( 27688645 )
2016
37
Anxiety and Shame as Risk Factors for Depression, Suicidality, and Functional Impairment in Body Dysmorphic Disorder and Obsessive Compulsive Disorder. ( 26998694 )
2016
38
Cognitive-Behavioral Therapy for Adolescent Body Dysmorphic Disorder: A Pilot Study. ( 26956653 )
2016
39
A Case of Treatment- resistant Depression and Body Dysmorphic Disorder: The Role of Electroconvulsive Therapy Revisited. ( 27672487 )
2016
40
Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. ( 27514293 )
2016
41
Body dysmorphic disorder symptoms and risk for suicide: The role of depression. ( 27760403 )
2016
42
Appearance evaluation of others' faces and bodies in anorexia nervosa and body dysmorphic disorder. ( 27566987 )
2016
43
Imagery Rescripting for Body Dysmorphic Disorder: A Multiple-Baseline Single-Case Experimental Design. ( 26956656 )
2016
44
A critical review of cosmetic treatment outcomes in body dysmorphic disorder. ( 27517118 )
2016
45
Eumorphic Plastic Surgery: Expectation Versus Satisfaction in Body Dysmorphic Disorder. ( 27251751 )
2016
46
Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder. ( 27429183 )
2016
47
Re: "Beauty Is in the Eye of the Beholder: Body Dysmorphic Disorder in Ophthalmic Plastic and Reconstructive Surgery". ( 27608160 )
2016
48
Commentary on: Prevalence of Body Dysmorphic Disorder Symptoms and Body Weight Concerns in Patients Seeking Abdominoplasty. ( 26879298 )
2016
49
The Body Dysmorphic Disorder Symptom Scale: Development and preliminary validation of a self-report scale of symptom specific dysfunction. ( 26971118 )
2016
50
Intolerance of uncertainty in body dysmorphic disorder. ( 26688272 )
2016

Variations for Body Dysmorphic Disorder

Copy number variations for Body Dysmorphic Disorder from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 63474 12 119100000 132349534 Deletion FBXW8 dysmorphic
2 63477 12 119100000 132349534 Deletion FZD10 dysmorphic
3 63480 12 119100000 132349534 Deletion NCOR2 dysmorphic
4 63483 12 119100000 132349534 Deletion P2RX2 dysmorphic
5 63486 12 119100000 132349534 Deletion RAN dysmorphic
6 63489 12 119100000 132349534 Deletion STX2 dysmorphic
7 63492 12 119100000 132349534 Deletion TBX3 dysmorphic
8 63495 12 119100000 132349534 Deletion TESC dysmorphic
9 63498 12 119100000 132349534 Deletion ULK1 dysmorphic

Expression for Body Dysmorphic Disorder

Search GEO for disease gene expression data for Body Dysmorphic Disorder.

Pathways for Body Dysmorphic Disorder

Pathways related to Body Dysmorphic Disorder according to KEGG:

36
# Name Kegg Source Accession
1 Serotonergic synapse hsa04726

Pathways related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 GPC1 GPC3 GPC6
2
Show member pathways
12.21 GALE GPC1 GPC3 GPC6
3
Show member pathways
12.09 GPC1 GPC3 GPC6
4
Show member pathways
12.01 GPC1 GPC3 GPC6
5
Show member pathways
11.89 GPC1 GPC3 GPC6
6
Show member pathways
11.76 GPC1 GPC3 GPC6
7
Show member pathways
11.36 GPC1 GPC3 GPC6
8
Show member pathways
10.96 GPC1 GPC3 GPC6

GO Terms for Body Dysmorphic Disorder

Cellular components related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.43 GPC1 GPC3 GPC6
2 anchored component of membrane GO:0031225 9.33 GPC1 GPC3 GPC6
3 Golgi lumen GO:0005796 9.13 GPC1 GPC3 GPC6
4 lysosomal lumen GO:0043202 8.8 GPC1 GPC3 GPC6

Biological processes related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.43 GPC1 GPC3 GPC6
2 glycosaminoglycan biosynthetic process GO:0006024 9.33 GPC1 GPC3 GPC6
3 glycosaminoglycan metabolic process GO:0030203 9.13 GPC1 GPC3 GPC6
4 glycosaminoglycan catabolic process GO:0006027 8.8 GPC1 GPC3 GPC6

Molecular functions related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparan sulfate proteoglycan binding GO:0043395 8.8 GPC1 GPC3 GPC6

Sources for Body Dysmorphic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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