MCID: BDY001
MIFTS: 38

Body Dysmorphic Disorder

Categories: Mental diseases

Aliases & Classifications for Body Dysmorphic Disorder

MalaCards integrated aliases for Body Dysmorphic Disorder:

Name: Body Dysmorphic Disorder 12 14
Body Dysmorphic Disorders 69
Dysmorphic Syndrome 12
Body Dysmorphia 12
Dysmorphophobia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060163

Summaries for Body Dysmorphic Disorder

Disease Ontology : 12 A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).

MalaCards based summary : Body Dysmorphic Disorder, also known as body dysmorphic disorders, is related to hypoparathyroidism-retardation-dysmorphism syndrome and birk-barel mental retardation dysmorphism syndrome. An important gene associated with Body Dysmorphic Disorder is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Glycosaminoglycan metabolism. The drugs Piracetam and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin.

Wikipedia : 72 Body dysmorphic disorder (BDD) is a mental disorder characterized by the obsessive idea that some aspect... more...

Related Diseases for Body Dysmorphic Disorder

Diseases related to Body Dysmorphic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 hypoparathyroidism-retardation-dysmorphism syndrome 12.1
2 birk-barel mental retardation dysmorphism syndrome 12.0
3 macrocephaly, macrosomia, facial dysmorphism syndrome 11.9
4 choanal atresia-hearing loss-cardiac defects-craniofacial dysmorphism syndrome 11.8
5 hypoparathyroidism-intellectual disability-dysmorphism syndrome 11.8
6 intellectual disability-severe speech delay-mild dysmorphism syndrome 11.8
7 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.6
8 intellectual disability-expressive aphasia-facial dysmorphism syndrome 11.6
9 night blindness-skeletal anomalies-dysmorphism syndrome 11.6
10 thin ribs-tubular bones-dysmorphism syndrome 11.6
11 short stature-deafness-neutrophil dysfunction-dysmorphism syndrome 11.6
12 intellectual disability-obesity-brain malformations-facial dysmorphism syndrome 11.6
13 aids dysmorphic syndrome 11.6
14 intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome 11.6
15 microcephaly-short stature-intellectual disability-facial dysmorphism syndrome 11.6
16 osteopenia-myopia-hearing loss-intellectual disability-facial dysmorphism syndrome 11.6
17 x-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 11.6
18 arachnodactyly - intellectual disability - dysmorphism 11.2
19 kcnk9 imprinting syndrome 10.7
20 epileptic encephalopathy, early infantile, 23 10.7
21 mental retardation, autosomal recessive 39 10.5
22 spondylometaphyseal dysplasia with bowed forearms and facial dysmorphism 10.5
23 steel syndrome 10.5
24 spinocerebellar ataxia with dysmorphism 10.5
25 fibromatosis, gingival, with distinctive facies 10.5
26 dislocation of hip, congenital, with hyperextensibility of fingers and facial dysmorphism 10.5
27 mental retardation and distinctive facial features with or without cardiac defects 10.5
28 fryns macrocephaly 10.5
29 reunion island larsen syndrome 10.5
30 hirschsprung disease with hypoplastic nails and dysmorphic facial features 10.5
31 xia-gibbs syndrome 10.5
32 beaulieu-boycott-innes syndrome 10.5
33 cono-spondylar dysplasia 10.5
34 tatton-brown-rahman syndrome 10.5
35 epiphyseal dysplasia hearing loss dysmorphism 10.5
36 burn-mckeown syndrome 10.5
37 culler-jones syndrome 10.5
38 mental retardation, autosomal dominant 36 10.5
39 mental retardation, autosomal dominant 23 10.5
40 autoimmune disease, multisystem, with facial dysmorphism 10.5
41 med13l haploinsufficiency syndrome 10.5
42 mental retardation with language impairment and with or without autistic features 10.5
43 klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism 10.5
44 cubitus valgus with mental retardation and unusual facies 10.5
45 short stature deafness neutrophil dysfunction 10.5
46 acromegaloid facial appearance syndrome 10.5
47 noonan syndrome 3 10.5
48 al-gazali-donnai-mueller syndrome 10.5
49 pfeiffer-palm-teller syndrome 10.5
50 brachioskeletogenital syndrome 10.5

Graphical network of the top 20 diseases related to Body Dysmorphic Disorder:



Diseases related to Body Dysmorphic Disorder

Symptoms & Phenotypes for Body Dysmorphic Disorder

Drugs & Therapeutics for Body Dysmorphic Disorder

Drugs for Body Dysmorphic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved Phase 4 7491-74-9
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Norepinephrine Approved Phase 4 51-41-2 439260
4 Etiracetam Investigational Phase 4 33996-58-6
5
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
6 Serotonin Agents Phase 4,Phase 3,Phase 2
7 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
8 Neuroprotective Agents Phase 4
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
10 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
11 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Nootropic Agents Phase 4
14 Anticonvulsants Phase 4
15 Antidepressive Agents Phase 4,Phase 3
16 Antidepressive Agents, Second-Generation Phase 4,Phase 3
17 Protective Agents Phase 4,Phase 2
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
20 Venlafaxine Hydrochloride Phase 4
21
Citalopram Approved Phase 3 59729-33-8 2771
22 Cholinergic Agents Phase 3
23 Muscarinic Antagonists Phase 3
24 Cholinergic Antagonists Phase 3
25 Parasympatholytics Phase 3
26 Peripheral Nervous System Agents Phase 3,Phase 2
27 Autonomic Agents Phase 3,Phase 2
28 Antiparkinson Agents Phase 3
29
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
30
Ondansetron Approved Phase 2 99614-02-5 4595
31
Lactitol Investigational Phase 2 585-86-4 3871
32 Central Nervous System Depressants Phase 2
33 Hormones Phase 2
34 Oxytocics Phase 2
35 Antioxidants Phase 2
36 Serotonin Antagonists Phase 2
37 Gastrointestinal Agents Phase 2
38 Dermatologic Agents Phase 2
39 Tranquilizing Agents Phase 2
40 Anti-Anxiety Agents Phase 2
41 Antiemetics Phase 2
42 Antipruritics Phase 2
43 Antipsychotic Agents Phase 2
44 silymarin Nutraceutical Phase 2
45 Milk Thistle Nutraceutical Phase 2
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Cocaine Approved, Illicit 50-36-2 5760 446220
48
Memantine Approved, Investigational 19982-08-2 4054
49
Cycloserine Approved Early Phase 1 68-41-7 401 6234
50
Diprenorphine Illicit, Vet_approved 14357-78-9

Interventional clinical trials:

(show all 29)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Levetiracetam in the Treatment of Body Dysmorphic Disorder Completed NCT00265109 Phase 4 Levetiracetam
2 Fluoxetine in Pediatric Body Dysmorphic Disorder Completed NCT00245635 Phase 4 Fluoxetine;Placebo
3 CBT as an Adjunct to SRIs in the Treatment of BDD Terminated NCT00211809 Phase 4 Venlafaxine
4 Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder Completed NCT00149799 Phase 3 Escitalopram;Placebo
5 Study of Patients With Body Image Issues Treated With 2 Different Behavioral Interventions Unknown status NCT01316627 Phase 2
6 Oxytocin Administration in BDD and OCD Recruiting NCT02671266 Phase 2 Oxytocin;Placebo
7 Milk Thistle in Body Dysmorphic Disorder Not yet recruiting NCT02843451 Phase 2 Milk Thistle;Placebo
8 Efficacy and Safety Study of Low-Dose Ondansetron For Adjunctive Therapy In Adult Patients With Obsessive-Compulsive Disorder Terminated NCT01275248 Phase 2 Ondansetron;Placebo
9 Attentional Bias in Body Dysmorphic Disorder Completed NCT01398904
10 Treatment Study Investigating New Cognitive Behavioral Therapy Treatment Manual for Body Dysmorphic Disorder Completed NCT00106223
11 Internet Cognitive Behavior Therapy (CBT) for Body Dysmorphic Disorder (BDD) Completed NCT01850433
12 Cognitive-Behavioral Therapy for Pediatric Body Dysmorphic Disorder Completed NCT01002326
13 An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder Completed NCT01038128 Memantine
14 Internet Delivered CBT for Body Dysmorphic Disorder Completed NCT02010619
15 Cognitive Behaviour Therapy (CBT) for Body Dysmorphic Disorder (BDD) Completed NCT00871143
16 Escitalopram Neuroimaging Supplement Completed NCT01398865
17 Assessment of Body Image in Patients With Rheumatoid Arthritis Completed NCT00832910
18 Effectiveness of Dance on Patients With Fibromyalgia Completed NCT00961805
19 Cortical Excitability in Obsessive-Compulsive and Related Disorders Completed NCT00029068
20 Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA) Completed NCT02381639
21 Interpretation Bias Modification for Body Dysmorphic Disorder Recruiting NCT02635152
22 D-Cycloserine Augmentation of Behavior Therapy for Individuals With Body Dysmorphic Disorder Recruiting NCT00842309 Early Phase 1 d-cycloserine;Placebo
23 Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder Recruiting NCT01453439
24 Body Image Disorder in Anorexia Nervosa and Virtual Reality Recruiting NCT03118921
25 White Light Scanning to Aid Body Contouring: A Pilot Project Recruiting NCT01093950
26 Brain Correlates of Self-Focused Processing Recruiting NCT02808702
27 Evaluation of Brain Opioid Receptor Activity in Anorexia Nervosa : a PET [11C]Diprenorphine Study Recruiting NCT02524301 Positron Emission Tomography using [11C]diprenorphine
28 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672
29 Smartphone-Administered App Treatment for Adults With Body Dysmorphic Disorder Not yet recruiting NCT03221738

Search NIH Clinical Center for Body Dysmorphic Disorder

Genetic Tests for Body Dysmorphic Disorder

Anatomical Context for Body Dysmorphic Disorder

MalaCards organs/tissues related to Body Dysmorphic Disorder:

39
Brain, Eye, Skin, Breast, Testes, Bone

Publications for Body Dysmorphic Disorder

Articles related to Body Dysmorphic Disorder:

(show top 50) (show all 527)
id Title Authors Year
1
The classification of body dysmorphic disorder symptoms in male and female adolescents. ( 28858657 )
2018
2
Face and Object Perception in Body Dysmorphic Disorder versus Obsessive-Compulsive Disorder: The Mooney Faces Task. ( 28528596 )
2017
3
Body dysmorphic disorder: history and curiosities. ( 28220373 )
2017
4
'Not just right' experiences and incompleteness in body dysmorphic disorder. ( 27918970 )
2017
5
Body dysmorphic disorder: Diagnosis, clinical aspects and treatment strategies. ( 28611331 )
2017
6
Prevalence of body dysmorphic disorder and associated features in German adolescents: A self-report survey. ( 28482195 )
2017
7
Neurocognitive Functioning in Young Adults with Subclinical Body Dysmorphic Disorder. ( 28367586 )
2017
8
Prevalence of Body Dysmorphic Disorder in Plastic Surgery and Dermatology Patients: A Systematic Review with Meta-Analysis. ( 28411353 )
2017
9
Long-Term Outcomes of Cognitive-Behavioral Therapy for Adolescent Body Dysmorphic Disorder. ( 28577583 )
2017
10
Patient-identified events implicated in the development of body dysmorphic disorder. ( 28285175 )
2017
11
Recent advances in understanding and managing body dysmorphic disorder. ( 28729345 )
2017
12
Sex Differences in the Presentation of Body Dysmorphic Disorder in a Community Sample of Adolescents. ( 28541768 )
2017
13
Body dysmorphic disorder: A serious concern for our young generation. ( 28784390 )
2017
14
Body dysmorphic disorder in the dermatology patient. ( 28511828 )
2017
15
A Review of Body Dysmorphic Disorder in Aesthetic Surgery Patients and the Legal Implications. ( 28204935 )
2017
16
Validation of Spanish Language Evaluation Instruments for Body Dysmorphic Disorder and the Dysmorphic Concern Construct. ( 28713311 )
2017
17
Reduced cortical thickness in body dysmorphic disorder. ( 27918913 )
2017
18
How individuals with body dysmorphic disorder (BDD) process their own face: a quantitative and qualitative investigation based on an eye-tracking paradigm. ( 28322616 )
2017
19
An Aberrant Presentation of Delusional Body Dysmorphic Disorder - Importance of Early Psychiatry Liaison. ( 28479822 )
2017
20
Body Dysmorphic Disorder in Patients With Autism Spectrum Disorder: A Reflection of Increased Local Processing and Self-Focus. ( 28366095 )
2017
21
Visual selective attention in body dysmorphic disorder, bulimia nervosa and healthy controls. ( 27998509 )
2017
22
Insight in body dysmorphic disorder (BDD) relative to obsessive-compulsive disorder (OCD) and psychotic disorders: Revisiting this issue in light of DSM-5. ( 28651226 )
2017
23
A multi-method analysis of distress tolerance in body dysmorphic disorder. ( 28826046 )
2017
24
A critical review of cosmetic treatment outcomes in body dysmorphic disorder. ( 27517118 )
2016
25
Body Dysmorphic Disorder in Patients Seeking Abdominoplasty, Rhinoplasty, and Rhytidectomy. ( 26818280 )
2016
26
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum Reproducibly Improves Symptoms of Body Dysmorphic Disorder. ( 27743837 )
2016
27
Re: "Beauty Is in the Eye of the Beholder: Body Dysmorphic Disorder in Ophthalmic Plastic and Reconstructive Surgery". ( 27608160 )
2016
28
Prevalence and correlates of body dysmorphic disorder in a community sample of adolescents. ( 27585880 )
2016
29
Training interpretation biases among individuals with body dysmorphic disorder symptoms. ( 26705744 )
2016
30
Suicidality in body dysmorphic disorder (BDD): A systematic review with meta-analysis. ( 27607741 )
2016
31
A Case of Treatment- resistant Depression and Body Dysmorphic Disorder: The Role of Electroconvulsive Therapy Revisited. ( 27672487 )
2016
32
Relationship between self-discrepancy and worries about penis size in men with body dysmorphic disorder. ( 26952016 )
2016
33
Prevalence of Body Dysmorphic Disorder and Surgeon Diagnostic Accuracy in Facial Plastic and Oculoplastic Surgery Clinics. ( 27930752 )
2016
34
Cognitive dysfunction in body dysmorphic disorder: new implications for nosological systems and neurobiological models. ( 27899165 )
2016
35
Cognitive-Behavioral Therapy for Body Dysmorphic Disorder by Proxy. ( 27423167 )
2016
36
Body dysmorphic disorder symptoms and risk for suicide: The role of depression. ( 27760403 )
2016
37
Reduced striatal dopamine D2/3 receptor availability in Body Dysmorphic Disorder. ( 26711686 )
2016
38
Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. ( 27514293 )
2016
39
Screening for Body Dysmorphic Disorder in a Dermatology Outpatient Setting at a Tertiary Care Centre. ( 27761090 )
2016
40
Body Dysmorphic Disorder in patients undergoing septorhinoplasty surgery. Should we be performing routine screening? ( 27627585 )
2016
41
Reply re: "Beauty Is in the Eye of the Beholder: Body Dysmorphic Disorder in Ophthalmic Plastic and Reconstructive Surgery". ( 27608161 )
2016
42
Prevalence of Body Dysmorphic Disorder and Muscle Dysmorphia Among Entry-Level Military Personnel. ( 27136659 )
2016
43
Measurement Invariance of a Body Dysmorphic Disorder Symptom Questionnaire Across Sex: The Body Image Questionnaire-Child and Adolescent Version. ( 27866170 )
2016
44
Anxiety and Shame as Risk Factors for Depression, Suicidality, and Functional Impairment in Body Dysmorphic Disorder and Obsessive Compulsive Disorder. ( 26998694 )
2016
45
Randomised controlled trials of psychological & pharmacological treatments for body dysmorphic disorder: A systematic review. ( 27544783 )
2016
46
CBT delivered via internet may improve outcomes in body dysmorphic disorder. ( 26982837 )
2016
47
Cognitive-Behavioral Therapy for Adolescent Body Dysmorphic Disorder: A Pilot Study. ( 26956653 )
2016
48
Appearance evaluation of others' faces and bodies in anorexia nervosa and body dysmorphic disorder. ( 27566987 )
2016
49
Prevalence of Body Dysmorphic Disorder Symptoms and Body Weight Concerns in Patients Seeking Abdominoplasty. ( 26851144 )
2016
50
Body Dysmorphic Disorder: Contraindication or Ethical Justification for Female Genital Cosmetic Surgery in Adolescents. ( 27717062 )
2016

Variations for Body Dysmorphic Disorder

Copy number variations for Body Dysmorphic Disorder from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 63474 12 119100000 132349534 Deletion FBXW8 dysmorphic
2 63477 12 119100000 132349534 Deletion FZD10 dysmorphic
3 63480 12 119100000 132349534 Deletion NCOR2 dysmorphic
4 63483 12 119100000 132349534 Deletion P2RX2 dysmorphic
5 63486 12 119100000 132349534 Deletion RAN dysmorphic
6 63489 12 119100000 132349534 Deletion STX2 dysmorphic
7 63492 12 119100000 132349534 Deletion TBX3 dysmorphic
8 63495 12 119100000 132349534 Deletion TESC dysmorphic
9 63498 12 119100000 132349534 Deletion ULK1 dysmorphic

Expression for Body Dysmorphic Disorder

Search GEO for disease gene expression data for Body Dysmorphic Disorder.

Pathways for Body Dysmorphic Disorder

Pathways related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 GPC1 GPC3 GPC6
2
Show member pathways
12.21 GALE GPC1 GPC3 GPC6
3
Show member pathways
12.09 GPC1 GPC3 GPC6
4
Show member pathways
12.01 GPC1 GPC3 GPC6
5
Show member pathways
11.89 GPC1 GPC3 GPC6
6
Show member pathways
11.76 GPC1 GPC3 GPC6
7
Show member pathways
11.36 GPC1 GPC3 GPC6
8
Show member pathways
10.96 GPC1 GPC3 GPC6

GO Terms for Body Dysmorphic Disorder

Cellular components related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.43 GPC1 GPC3 GPC6
2 anchored component of membrane GO:0031225 9.33 GPC1 GPC3 GPC6
3 Golgi lumen GO:0005796 9.13 GPC1 GPC3 GPC6
4 lysosomal lumen GO:0043202 8.8 GPC1 GPC3 GPC6

Biological processes related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.43 GPC1 GPC3 GPC6
2 glycosaminoglycan biosynthetic process GO:0006024 9.33 GPC1 GPC3 GPC6
3 glycosaminoglycan metabolic process GO:0030203 9.13 GPC1 GPC3 GPC6
4 glycosaminoglycan catabolic process GO:0006027 8.8 GPC1 GPC3 GPC6

Molecular functions related to Body Dysmorphic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparan sulfate proteoglycan binding GO:0043395 8.8 GPC1 GPC3 GPC6

Sources for Body Dysmorphic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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