MCID: BND004
MIFTS: 28

Bone Deterioration Disease

Categories: Bone diseases

Aliases & Classifications for Bone Deterioration Disease

MalaCards integrated aliases for Bone Deterioration Disease:

Name: Bone Deterioration Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0080007

Summaries for Bone Deterioration Disease

Disease Ontology : 12 A bone structure disease that results_in change or damage of structure located in bone.

MalaCards based summary : Bone Deterioration Disease is related to degenerative disc disease and spinal stenosis. An important gene associated with Bone Deterioration Disease is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include bone and bone, and related phenotypes are cardiovascular system and limbs/digits/tail

Related Diseases for Bone Deterioration Disease

Diseases related to Bone Deterioration Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 degenerative disc disease 30.4 ACAN BMP2 COL9A3 GDF5 IVD MMP3
2 spinal stenosis 28.9 ACAN BMP7 COL2A1 COL9A2 COL9A3 MMP3
3 polyradiculopathy 10.3 ACAN BMP2 IVD
4 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.3 COL9A2 COL9A3
5 squamous cell carcinoma of the hypopharynx 10.2 MMP3 TIMP1
6 chondrosarcoma 10.2 MMP13 MMP3 SOX9
7 autosomal recessive stickler syndrome 10.2 COL9A2 COL9A3
8 brachydactyly, type a2 10.2 BMP2 GDF5
9 achondrogenesis, type ia 10.2 ACAN COL2A1
10 synovitis 10.2 IL1B MMP13 MMP3
11 conjunctivochalasis 10.1 MMP3 TIMP1
12 coxa vara 10.1 COL2A1 MMP13
13 sorsby fundus dystrophy 10.1 MMP13 MMP3 TIMP1
14 cartilage disease 10.1 ACAN COL2A1
15 gastroschisis 10.1 IL1B MMP3
16 aortic aneurysm, familial abdominal, 1 10.1 MMP13 MMP3 TIMP1
17 scheuermann disease 10.1 COL2A1 COL9A3
18 pseudoachondroplasia 10.1 ACAN COL9A2 COL9A3
19 spondyloepiphyseal dysplasia with congenital joint dislocations 10.1 ACAN COL2A1
20 back pain 10.0 CILP COL9A2 COL9A3
21 fundus dystrophy 10.0 MMP13 MMP3 TIMP1
22 atelosteogenesis 10.0 COL9A2 IVD
23 joint disorders 10.0 IL1B MMP3 TIMP1
24 achondrogenesis, type ii 10.0 ACAN COL2A1
25 pseudoarthrosis 10.0 BMP2 BMP7
26 ischemic bone disease 10.0 ACAN BMP2 COL2A1
27 vitreoretinal degeneration 10.0 COL2A1 COL9A2
28 periodontitis 10.0 IL1B MMP3 TIMP1
29 synovial chondromatosis 10.0 BMP2 COL2A1 SOX9
30 periodontal disease 10.0 IL1B MMP3 TIMP1
31 achondrogenesis 9.9 COL2A1 COL9A2
32 brachydactyly 9.9 BMP2 COL2A1 GDF5
33 corneal ulcer 9.9 IL1B MMP3
34 bone development disease 9.9 COL2A1 COL9A2 SOX9
35 orofacial cleft 9.8 BMP2 COL2A1 RPS17
36 proximal symphalangism 9.8 BMP2 BMP7 GDF5
37 stickler syndrome 9.8 COL2A1 COL9A2 COL9A3
38 spondylolysis 9.7 BMP7 FTH1 GDF5
39 multiple epiphyseal dysplasia 9.6 ACAN COL2A1 COL9A2 COL9A3
40 arthritis 9.6 ACAN COL2A1 IL1B MMP13 MMP3
41 intervertebral disc disease 9.6 ACAN CILP COL9A2 COL9A3 IL1B
42 bone inflammation disease 9.2 ACAN COL2A1 IL1B MMP13 MMP3 TIMP1
43 osteochondritis dissecans 9.1 ACAN BMP7 COL9A2 COL9A3 MMP13 MMP3
44 spondylolisthesis 9.1 BMP2 BMP7 FTH1 GDF5 IVD MMP3
45 osteoarthritis 8.6 ACAN CILP COL2A1 GDF5 IL1B MMP13
46 bone structure disease 7.6 ACAN BMP2 BMP7 CILP COL2A1 COL9A3

Graphical network of the top 20 diseases related to Bone Deterioration Disease:



Diseases related to Bone Deterioration Disease

Symptoms & Phenotypes for Bone Deterioration Disease

MGI Mouse Phenotypes related to Bone Deterioration Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 TIMP1 BMP2 BMP7 COL2A1 FTH1 IL1B
2 limbs/digits/tail MP:0005371 9.56 TIMP1 BMP2 BMP7 COL2A1 COL9A2 GDF5
3 hearing/vestibular/ear MP:0005377 9.55 SOX9 BMP2 BMP7 COL2A1 COL9A2
4 skeleton MP:0005390 9.32 TIMP1 BMP2 BMP7 COL2A1 COL9A2 GDF5

Drugs & Therapeutics for Bone Deterioration Disease

Search Clinical Trials , NIH Clinical Center for Bone Deterioration Disease

Genetic Tests for Bone Deterioration Disease

Anatomical Context for Bone Deterioration Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Deterioration Disease:

18
Bone

MalaCards organs/tissues related to Bone Deterioration Disease:

38
Bone

Publications for Bone Deterioration Disease

Variations for Bone Deterioration Disease

Expression for Bone Deterioration Disease

Search GEO for disease gene expression data for Bone Deterioration Disease.

Pathways for Bone Deterioration Disease

Pathways related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
2
Show member pathways
13.17 ACAN COL2A1 COL9A2 COL9A3 MMP13 MMP3
3
Show member pathways
12.81 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
4
Show member pathways
12.66 COL2A1 COL9A2 COL9A3 MMP13 MMP3
5
Show member pathways
12.49 BMP2 BMP7 GDF5 IL1B TIMP1
6 11.99 BMP2 BMP7 GDF5
7
Show member pathways
11.98 ACAN COL2A1 COL9A2 COL9A3 MMP13 MMP3
8
Show member pathways
11.98 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
9
Show member pathways
11.97 COL2A1 COL9A2 COL9A3
10 11.84 ACAN COL2A1 IL1B SOX9
11 11.82 IL1B MMP3 TIMP1
12 11.77 BMP7 COL2A1 SOX9
13
Show member pathways
11.75 MMP13 MMP3 TIMP1
14 11.69 MMP13 MMP3 TIMP1
15 11.65 BMP2 BMP7 GDF5
16 11.62 ACAN BMP2 BMP7 COL2A1 GDF5 SOX9
17
Show member pathways
11.56 BMP2 BMP7 GDF5
18 11.49 BMP7 IL1B TIMP1
19 11.47 ACAN BMP7 COL2A1 MMP13 SOX9
20 11.45 COL2A1 MMP13 MMP3 TIMP1
21 11.43 ACAN COL9A2 COL9A3
22 11.02 BMP2 BMP7
23 11.01 IL1B TIMP1
24 10.95 BMP2 BMP7
25 10.92 BMP2 COL2A1
26 10.51 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3

GO Terms for Bone Deterioration Disease

Cellular components related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
2 endoplasmic reticulum lumen GO:0005788 9.73 COL2A1 COL9A2 COL9A3 TIMP1
3 collagen trimer GO:0005581 9.65 COL2A1 COL9A2 COL9A3 MMP13 TIMP1
4 basement membrane GO:0005604 9.58 ACAN COL2A1 TIMP1
5 extracellular matrix GO:0031012 9.56 ACAN BMP7 CILP COL2A1 MMP13 MMP3
6 collagen type IX trimer GO:0005594 9.37 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.23 ACAN CILP COL2A1 COL9A2 COL9A3 MMP13
8 extracellular space GO:0005615 10.02 ACAN BMP2 BMP7 CILP COL2A1 GDF5

Biological processes related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.97 BMP2 BMP7 GDF5 IL1B TIMP1
2 negative regulation of cell proliferation GO:0008285 9.93 BMP2 BMP7 FTH1 IL1B SOX9
3 central nervous system development GO:0007417 9.83 ACAN COL2A1 SOX9
4 positive regulation of neuron differentiation GO:0045666 9.79 BMP2 BMP7 GDF5
5 collagen catabolic process GO:0030574 9.76 COL2A1 MMP13 MMP3
6 SMAD protein signal transduction GO:0060395 9.73 BMP2 BMP7 GDF5
7 extracellular matrix organization GO:0030198 9.72 ACAN COL2A1 COL9A2 COL9A3 SOX9
8 ossification GO:0001503 9.71 BMP2 BMP7 COL2A1 SOX9
9 cell development GO:0048468 9.7 BMP2 BMP7 GDF5
10 endochondral ossification GO:0001958 9.67 COL2A1 MMP13
11 positive regulation of p38MAPK cascade GO:1900745 9.67 BMP2 IL1B
12 cartilage condensation GO:0001502 9.67 COL2A1 SOX9
13 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.67 BMP2 BMP7 GDF5
14 extracellular matrix disassembly GO:0022617 9.67 ACAN MMP13 MMP3 TIMP1
15 positive regulation of chondrocyte differentiation GO:0032332 9.66 GDF5 SOX9
16 tissue homeostasis GO:0001894 9.66 COL2A1 SOX9
17 negative regulation of chondrocyte differentiation GO:0032331 9.65 GDF5 SOX9
18 chondrocyte development GO:0002063 9.65 ACAN SOX9
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.65 BMP2 BMP7 IL1B
20 positive regulation of cartilage development GO:0061036 9.64 BMP2 SOX9
21 endocardial cushion morphogenesis GO:0003203 9.64 BMP2 SOX9
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 BMP7 IL1B
23 limb bud formation GO:0060174 9.63 COL2A1 SOX9
24 epithelial to mesenchymal transition GO:0001837 9.63 BMP2 BMP7 SOX9
25 embryonic skeletal joint morphogenesis GO:0060272 9.62 BMP7 COL2A1
26 notochord development GO:0030903 9.61 COL2A1 SOX9
27 mesenchymal cell differentiation GO:0048762 9.61 BMP2 BMP7
28 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.6 BMP2 CILP
29 proteoglycan metabolic process GO:0006029 9.59 BMP2 COL2A1
30 otic vesicle development GO:0071599 9.58 COL2A1 SOX9
31 chondrocyte differentiation GO:0002062 9.56 BMP2 COL2A1 GDF5 SOX9
32 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.55 GDF5 SOX9
33 mesenchyme development GO:0060485 9.51 BMP2 BMP7
34 cellular response to BMP stimulus GO:0071773 9.46 BMP2 BMP7 COL2A1 SOX9
35 monocyte aggregation GO:0070487 9.43 BMP7 IL1B
36 skeletal system development GO:0001501 9.43 ACAN BMP2 BMP7 COL2A1 COL9A2 SOX9
37 cartilage development GO:0051216 9.17 BMP2 BMP7 COL2A1 GDF5 MMP13 SOX9

Molecular functions related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 BMP2 BMP7 GDF5 TIMP1
2 cytokine activity GO:0005125 9.35 BMP2 BMP7 GDF5 IL1B TIMP1
3 transforming growth factor beta receptor binding GO:0005160 9.33 BMP2 BMP7 GDF5
4 BMP receptor binding GO:0070700 9.32 BMP2 BMP7
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.8 COL2A1 COL9A2 COL9A3

Sources for Bone Deterioration Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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