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Bone Fracture malady

Bone diseases category
37 genes, 21 tissues, 127 related diseases, clinical trials.

Summaries for Bone Fracture

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63Wikipedia, 32MalaCards
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Wikipedia:63 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards: Bone Fracture is related to osteoporosis and obesity. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are MIF Action Through Endocytic Pathway and Crosslinking of collagen fibrils. The compounds procollagen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Bone Fracture

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30LifeMap Discovery™, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone fracture 30 44


Related Diseases for Bone Fracture

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bone Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.6COL1A1, BGLAP, CALCA, BMP2, ESR2
2obesity30.3CAV1
3bone carcinoma30.3BMP2, CAV1, BGLAP
4hepatitis30.2CAV1
5hyperparathyroidism30.2BGLAP, CALCA
6diabetes mellitus30.0ESR2, CD14, BMP2, CALCA, BGLAP
7prostate cancer30.0ESR2, BMP2, CAV1, BGLAP
8breast cancer30.0CALCA, CAV1, PDGFA, BMP2, NUDT6, CD14
9celiac disease29.8LCT
10thyroiditis29.8CALCA
11parathyroid adenoma29.8CALCA
12vascular disease29.8MB
13myocardial infarction29.8MB, CD14
14liver cirrhosis29.8PDGFA, CD14
15osteitis fibrosa29.8BGLAP
16osteogenesis imperfecta type i29.8BGLAP, COL1A1
17myeloma29.8CD14, BMP2, BGLAP
18sarcoma29.8CAV1, PDGFA, MB, BMP2
19adenoma29.8CALCA, CAV1, TLR4, NUDT6, ESR2
20leukemia29.8CAV1, TLR4, BMP2, NUDT6, CD14, ESR2
21facial paralysis10.4
22osteoporotic fracture10.3
23spinal muscular atrophy type 1 with congenital bone fractures10.2
24cervicitis10.1
25meningitis10.1
26neuropathy10.1
27primary hyperparathyroidism10.1
28cerebritis10.1
29pharyngitis10.1
30cerebrotendinous xanthomatosis10.1
31hepatocellular carcinoma10.1
32hypogonadism10.1
33prostatitis10.1
34tuberculosis10.1
35xanthomatosis10.1
36pancreatitis10.0CELA3B
37periodontitis10.0TLR4
38galactosemia10.0TLR4
39inflammatory bowel disease10.0TLR4
40myocarditis10.0MB
41endometriosis10.0ESR2
42muscular dystrophy10.0ANO5
43giant cell tumor10.0CALCA
44peritonitis10.0CD14, MB
45osteomyelitis10.0BMP2
46diarrhea10.0CALCA, LCT
47osteogenesis imperfecta10.0BGLAP, COL1A1
48thyroid cancer10.0CALCA, BGLAP
49coronary heart disease10.0MB, TLR4
50paget's disease of bone10.0BGLAP, CALCA

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Clinical Features for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bone Fracture

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Search CenterWatch for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bone Fracture:
Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
Ovation
Stromal vascular fraction cells for osteoporotic bone fractures
Embryonic/Adult Cultured Cells Related to Bone Fracture:
Bone marrow-derived mesenchymal stem cells, PMID: 23180104
Stromal vascular fraction cells, PMIDs: 21605897, 16488036

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Bone Fracture:

32
Bone, Bone marrow, Breast, Liver, Kidney, Spinal cord, Brain, Prostate, Endothelial, Skeletal muscle, Myeloid, B cells, Testes, Eye, Thyroid, Pancreas, Lung, Lymph node, Cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Bone Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
limbs/digits/tail phenotype
MP:000537110.2PCOLCE, SMN1
2
respiratory system phenotype
MP:000538810.2CAV1, MB, ESR2
3
hearing/vestibular/ear phenotype
MP:000537710.1TLR4, BMP2, ESR2, SMN1
4
skeleton phenotype
MP:00053909.9SMN1, ESR2, PCOLCE, CD14, BMP2, PDGFA
5
adipose tissue phenotype
MP:00053759.7ESR2, CD14, TLR4, CAV1, COL1A1
6
muscle phenotype
MP:00053699.6CAV1, TLR4, PDGFA, MB, PCOLCE, ESR2
7
integument phenotype
MP:00107719.3COL1A1, CALCA, CAV1, TLR4, PDGFA, IL1RAP
8
cardiovascular system phenotype
MP:00053859.2COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
9
homeostasis/metabolism phenotype
MP:00053768.9COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
10
nervous system phenotype
MP:00036318.8COL1A1, CALCA, CAV1, TLR4, PDGFA, BMP2

Publications for Bone Fracture

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Sources:
50PubMed
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Articles related to Bone Fracture:

(show top 50)    (show all 871)
idTitleAuthorsYear
1
Use of depot medroxyprogesterone acetate contraception and incidence of bone fracture. (23635623)
2013
2
A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization. (23897412)
2013
3
TNF-I+ accelerates bone fracture healing. (23951487)
2012
4
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (22504420)
2012
5
Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication. (20926594)
2011
6
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. (21533022)
2011
7
Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture. (20200987)
2010
8
Influence of electromagnetic fields on bone fracture in rats: role of CAPE. (19618694)
2009
9
Role of bone morphogenetic proteins and their antagonists in healing of bone fracture. (19273241)
2009
10
Microdamage detection and repair in bone: fracture mechanics, histology, cell biology. (19478407)
2009
11
Bone fracture: an unusual presentation of acute megakaryoblastic leukemia. (19206010)
2009
12
An intermaxillary fixation screw traction wire: an aid for facial bone fracture repair. (19546677)
2009
13
The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women. (19037576)
2009
14
Pneumolabyrinth without temporal bone fracture: different outcomes for hearing recovery. (18425047)
2008
15
Does calcium supplementation reduce the risk of osteoporotic fracture and bone loss? (18091729)
2008
16
Angiogenesis in bone fracture healing: a bioregulatory model. (18155732)
2008
17
Computer hexapod assisted orthopaedic surgery (CHAOS) in the correction of long bone fracture and deformity. (17485999)
2007
18
Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. (17070526)
2007
19
Brain herniation into the middle ear following temporal bone fracture. (16158540)
2005
20
Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. (16157834)
2005
21
Lymphoscintigraphic monitoring of the lower limb lymphatic system response to bone fracture and healing. (16190818)
2005
22
BMP-14 deficiency inhibits long bone fracture healing: a biochemical, histologic, and radiographic assessment. (16247308)
2005
23
Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. (15207775)
2004
24
Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women. (14595528)
2004
25
What is your neurologic diagnosis? Stylohyoid bone fracture and possible petrous temporal bone fracture. (12619836)
2003
26
The fate of soft callus chondrocytes during long bone fracture repair. (12507580)
2003
27
Old temporal bone fracture. (12735150)
2003
28
Temporal bone fracture with hemotympanum. (14702867)
2003
29
Reversal of the detrimental effects of chronic protein malnutrition on long bone fracture healing. (11147687)
2001
30
Prediction of bone fracture by bone mineral density in Taiwanese. (11802519)
2001
31
Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta. (11760017)
2001
32
Management of facial paralysis resulting from temporal bone fractures: Our experience in 115 cases. (11458219)
2001
33
Temporal bone fracture and its complications. (11834156)
2001
34
Bone fracture receiving LH-RH agonists for prostatic cancer]. (10897579)
2000
35
The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. (10027889)
1999
36
Physiotherapy in the process of bone fracture healing using external fixators. (17984870)
1999
37
Endoscopic osteosynthesis for frontal bone fracture. (9641286)
1998
38
A data-logging system to monitor bone fracture movement continuously. (9239649)
1997
39
Long bone fracture healing: IGF-I concentrations and specific binding to erythrocytes. (8910819)
1996
40
Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. (8703580)
1996
41
Expression of osteoblastic markers in cultured human bone and fracture callus cells. (8751141)
1995
42
Avascular necrosis of the femoral epiphysis complicating a minimally displaced fracture of solitary bone cyst of the neck of the femur in a child. A case report. (8020210)
1994
43
One-piece reimplantation treatment of the "Humpty Dumpty" frontal bone fracture. (1992275)
1991
44
Long bone fracture in a spinal-cord-injured patient: complication of treatment--a case report and review of the literature. (1942162)
1991
45
Serum bone-gla protein after fracture. (2394055)
1990
46
Keratoconjunctivitis sicca associated with fracture of the stylohyoid bone in a horse. (2917892)
1989
47
Malakoplakia of bone. An unusual cause of pathologic fracture in an immunosuppressed patient. (4064394)
1985
48
Stress fracture of the iliac bone with subfascial femoral neuropathy: unusual complications at a bone graft donor site: case report. (6860856)
1983
49
Bilateral transverse temporal bone fracture: case report. (6038406)
1967
50
Fixation of malar bone fracture with a large Foley catheter. (13931496)
1962

Genetic Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
MIF Action Through Endocytic Pathway51
10.2CD14, TLR4
2
Crosslinking of collagen fibrils53
10.2COL1A1, PCOLCE
3
Amoebiasis29
10.1CD14, TLR4, COL1A1
4
Toll Comparative Pathway51
Hide members
10.0IL1RAP, CD14, TLR4
5
Transcription NF-kB signaling pathway12
10.0TLR4, CD14, IL1RAP
6
Immune response Bacterial infections in normal airways
Hide members
10.0TLR4, CD14, IL1RAP
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.0CALCA, BGLAP, COL1A1
8
NF-KappaB Family Pathway51
Hide members
9.9NUDT6, BMP2, PDGFA, TLR4
9
Cell adhesion Integrin-mediated cell adhesion and migration
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9.9MYH2, MYH7, CAV1, COL1A1
10
Collagen biosynthesis and modifying enzymes53
Hide members
9.9PCOLCE, BMP2, PDGFA, COL1A1
11
PAK Pathway51
Hide members
9.8PDGFA, BMP2, MYH7, MYH2, NUDT6
12
Nanog in Mammalian ESC Pluripotency51
Hide members
9.7CAV1, PDGFA, BMP2, NUDT6, ESR2
13
Rho Family GTPases51
Hide members
9.5ESR2, COL1A1, PDGFA, BMP2, MYH7, MYH2

Compounds for genes affiliated with Bone Fracture

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1procollagen4410.8PCOLCE
2pge24410.6COL1A1, MB
3monophosphoryl lipid a4410.5TLR4, CD14
4alizarin red s4410.5BMP2, BGLAP
5cycloheximide4410.5CAV1, PDGFA
6calcium gluconate4410.5BGLAP, CALCA
7ipriflavone4410.5BGLAP, CALCA
8methylmethacrylate4410.4BMP2, MB
9tio24410.4BMP2, BGLAP
10chitosan4410.4BGLAP, MB, BMP2
11zoledronic acid4410.4BGLAP, CALCA, BMP2
12glucuronoxylomannan4410.4CD14, TLR4
13alendronate44 49 1112.4BGLAP, CALCA, BMP2
14glycolipid4410.3CAV1, TLR4, CD14
15alginate4410.3BMP2, MB, BGLAP
16glutamate4410.3MB, MYH7
17carbohydrates4410.3LCT, TLR4, MB, CD14
18fluoride4410.3MB, CALCA, BGLAP
19hydrocortisone44 2 59 1113.3CD14, CALCA, LCT, BGLAP
20acetylcholine44 49 28 11 2414.3NUDT6, MB, CAV1, CALCA
21raloxifene44 28 49 1113.3ESR2, BMP2, CALCA, BGLAP
22hydroxyproline44 11 2412.2CALCA, BGLAP, COL1A1
23calcitriol44 59 11 2413.2BGLAP, CALCA, TLR4, BMP2, CD14
241,25 dihydroxy vitamin d34410.2COL1A1, BGLAP, CALCA, BMP2, CD14
25alfacalcidol44 59 1112.2CALCA, BGLAP
26wortmannin4410.2CD14, NUDT6, BMP2, TLR4, CAV1
27creatinine4410.1CD14, MYH7, BMP2, MB, BGLAP
28dopamine44 28 11 2413.1MB, BMP2, NUDT6, ESR2
29simvastatin44 49 59 28 11 2415.1COL1A1, BGLAP, CAV1, TLR4, BMP2
30lactate4410.1CALCA, TLR4, MB, BMP2, NUDT6, CD14
3124,25-dihydroxyvitamin d34410.1CALCA, BGLAP
32ribonucleic acid4410.0COL1A1, PDGFA, BMP2, NUDT6, ESR2, SMN1
33guanidine hydrochloride4410.0BGLAP, MB, BMP2
34cyclosporin a44 28 5912.0BGLAP, CALCA, CAV1, TLR4, BMP2, CD14
35paraffin449.9BGLAP, CAV1, PDGFA, MB, CD14, ESR2
36teriparatide44 1110.9CALCA, BGLAP
37oligonucleotide449.9COL1A1, CAV1, PDGFA, BMP2, MYH7, CD14
38heparin44 28 11 2412.9BGLAP, LCT, CAV1, PDGFA, MB, BMP2
39testosterone44 59 11 2412.9BGLAP, CALCA, CAV1, MB, BMP2, NUDT6
40alanine449.8COL1A1, BGLAP, CAV1, TLR4, MB, BMP2
41aspartate449.8CD14, MB, TLR4, BGLAP, COL1A1
42nitric oxide44 11 2411.8CALCA, CAV1, TLR4, BMP2, NUDT6, IL1RAP
43serine449.7BGLAP, CAV1, TLR4, MB, BMP2, MYH7
44retinoic acid44 2410.6COL1A1, BGLAP, CAV1, TLR4, PDGFA, BMP2
45vitamin d449.6ESR2, COL1A1, BGLAP, CALCA, CAV1, TLR4
46dexamethasone44 49 28 1112.5COL1A1, BGLAP, CAV1, TLR4, PDGFA, BMP2
47arginine449.5COL1A1, BGLAP, CAV1, MB, BMP2, MYH7
48cysteine449.4CAV1, LCT, BGLAP, COL1A1, TLR4, MB
49vegf449.3COL1A1, BGLAP, CALCA, CAV1, TLR4, PDGFA
50calcium44 49 11 2412.0TLR4, CAV1, CALCA, LCT, BGLAP, COL1A1

GO Terms for genes affiliated with Bone Fracture

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Sources:
16Gene Ontology
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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:03298210.2MYH2, MYH7
2muscle myosin complexGO:0058599.9MYH2, MYH7
3extracellular spaceGO:0056159.4COL1A1, BGLAP, CALCA, PDGFA, BMP2, CD14
4extracellular regionGO:0055769.0CELA3B, COL1A1, BGLAP, CALCA, PDGFA, BMP2

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3CD14, TLR4
2positive regulation of ossificationGO:04577810.2BMP2, CALCA
3cytosolic calcium ion homeostasisGO:05148010.2CAV1, CALCA
4osteoblast differentiationGO:00164910.1COL1A1, BGLAP, BMP2
5response to hypoxiaGO:00166610.0BMP2, MB, PDGFA, CAV1
6cell-cell signalingGO:0072679.9CALCA, PDGFA, BMP2, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.9TLR4, PDGFA, BMP2
8inflammatory responseGO:0069549.6IL1RAP, CD14, BMP2, CALCA

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, TLR4
2peptidase activator activityGO:01650410.1PCOLCE, CAV1
3platelet-derived growth factor bindingGO:0484079.8PDGFA, COL1A1

Products for genes affiliated with Bone Fracture

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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