MCID: BNF002
MIFTS: 45

Bone Fracture malady

Bone diseases category

Summaries for Bone Fracture

About this section


Wikipedia:65 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards based summary: Bone Fracture is related to prostate cancer and osteoporosis. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are RhoGDI Pathway and Clathrin derived vesicle budding. The compounds (r)-(+)-blebbistatin and bts have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord.

Aliases & Classifications for Bone Fracture

About this section

Bone Fracture, Aliases & Descriptions:

Name: Bone Fracture 32 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Related Diseases for Bone Fracture

About this section

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Symptoms for Bone Fracture

About this section

Drugs & Therapeutics for Bone Fracture

About this section

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

About this section

Anatomical Context for Bone Fracture

About this section

MalaCards organs/tissues related to Bone Fracture:

33
Bone, Brain, Spinal cord, Liver, Breast, Bone marrow, Skeletal muscle, Kidney, Prostate, Eye, Lymph node, Cortex, Lung, Thyroid, Testes, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

About this section

Publications for Bone Fracture

About this section

Articles related to Bone Fracture:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Bone fracture in breast cancer patients with isolated bone metastasis. (25800315)
2015
2
Early stages of bone fracture healing: formation of a fibrin-collagen scaffold in the fracture hematoma. (25537828)
2015
3
Plasma homocysteine, B vitamins and bone mineral density in osteoporosis: a possible risk for bone fracture. (25335377)
2014
4
The relationship between patient age and pain management of acute long-bone fracture in the ED. (25312220)
2014
5
Comparison study of the use of absorbable and nonabsorbable materials as internal splints after closed reduction for nasal bone fracture. (25075356)
2014
6
Bone Fracture Toughness and Strength Correlate with Collagen Cross-Link Maturity in a Dose-Controlled Lathyrism Mouse Model. (25213475)
2014
7
Temporal bone fracture causing superior semicircular canal dehiscence. (25295207)
2014
8
Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)
2013
9
Circuit modeling of the electrical impedance: part III. Disuse following bone fracture. (23587651)
2013
10
Estimation of 10-year probability bone fracture in a selected sample of Palestinian people using fracture risk assessment tool. (24093559)
2013
11
Development of an ex vivo protocol to model bone fracture in laying hens resulting from collisions. (23785487)
2013
12
Bone fracture exacerbates murine ischemic cerebral injury. (23438676)
2013
13
Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing. (23937065)
2013
14
3D identification of trabecular bone fracture zone using an automatic image registration scheme: A validation study. (22682259)
2012
15
Cochlear implantation in posttraumatic bilateral temporal bone fracture. (22328130)
2012
16
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. (21507568)
2011
17
Mechanisms of hyoid bone fracture after modelling: evaluation of anthropological criteria defining two relevant models. (21764532)
2011
18
Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. (20445964)
2011
19
A new approach to the treatment of nasal bone fracture: radiologic classification of nasal bone fractures and its clinical application. (21474225)
2011
20
Extranasal splint made of a polyethylene container: a distinct fixation method after nasal bone fracture reduction surgery. (21788804)
2011
21
Bone mineral density and bone fracture in male patients receiving long-term suppressive levothyroxine treatment for differentiated thyroid carcinoma. (20960170)
2010
22
Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. (20855498)
2010
23
Disseminated tuberculosis complicated with tuberculous meningitis, miliary tuberculosis, and thoracal bone fracture while investigating a cervical lymphadenopathy. Tuberculosis: a hidden enemy? (20672504)
2010
24
Comparison of the frequency of old septal deviation in patients with and without traumatic nasal bone fracture. (21287462)
2010
25
Time-frequency analysis to detect bone fracture in impact biomechanics. Application to the thorax. (19540145)
2009
26
Ultrasonic monitoring of bone fracture healing. (18599412)
2008
27
Temporal bone fracture with ossicular dislocation caused by a blow to the opposite side of the head. (17826019)
2008
28
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. (17950532)
2007
29
Assessing the risk of bone fracture among postmenopausal women who are receiving adjuvant hormonal therapy for breast cancer. (17519070)
2007
30
Effect of long tubular bone fracture on serum levels of leptin, acute phase proteins and biochemical markers for organ functions]. (16464379)
2006
31
Obscure temporal bone fracture with conductive hearing loss. (12619459)
2003
32
Pneumolabyrinth: an unusual finding in a temporal bone fracture. (12697360)
2003
33
Efficacy of monitoring long-bone fracture healing by measurement of either bone stiffness or resonant frequency: numerical simulation. (11117288)
2000
34
Is exposure to HMG-CoA reductase inhibitors (statins), fibrates, or other lipid-lowering drugs associated with reduced risk of bone fracture in older patients? (11032211)
2000
35
Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer. (10971270)
2000
36
The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. (10027889)
1999
37
Vitamin D receptor genotype and the risk of bone fractures in women. (9730033)
1998
38
An interspecies comparison of bone fracture properties. (9713681)
1998
39
Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. (8231848)
1993
40
Principles of long bone fracture management. (1570435)
1992
41
Air in the temporomandibular joint fossa: CT sign of temporal bone fracture. (2068313)
1991
42
Electrostimulation and bone fracture healing. (2004532)
1991
43
The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. (2125994)
1990
44
Histopathology of the facial nerve after longitudinal temporal bone fracture. (3386375)
1988
45
Pneumolabyrinth as a late sequela of temporal bone fracture. (3232721)
1988
46
Retardation of bone fracture healing in experimental diabetes. (3623654)
1987
47
A cumulative damage model for bone fracture. (3981298)
1985
48
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat. (6202957)
1984
49
The effects of pulsed magnetic fields of the type used in the stimulation of bone fracture healing. (6339155)
1983
50
Bilateral transverse temporal bone fracture: case report. (6038406)
1967

Variations for Bone Fracture

About this section

Expression for genes affiliated with Bone Fracture

About this section

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

About this section

Pathways related to Bone Fracture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4MYH2, MYH7
2
Show member pathways
9.4MYH2, MYH7
3
Show member pathways
9.4MYH2, MYH7
49.4MYH7, MYH2
5
Show member pathways
8.9NUDT6, MYH7, MYH2
6
Show member pathways
8.9MYH2, MYH7, NUDT6
7
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
8.9CAV1, MYH2, MYH7
8
Show member pathways
8.9MYH7, MYH2, CAV1

Compounds for genes affiliated with Bone Fracture

About this section

Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1(r)-(+)-blebbistatin619.7MYH7, MYH2
2bts619.7MYH7, MYH2
3(s)-(-)-blebbistatin619.7MYH7, MYH2
4(+-)-blebbistatin619.7MYH7, MYH2
5actomyosin459.7MYH2, MYH7
6gp 130459.5CAV1, MYH7
7procollagen459.5PCOLCE, BGLAP
8bromodeoxyuridine459.3MYH7, NUDT6
9caffeine45 30 3 51 26 1314.2NUDT6, BGLAP
10simvastatin45 51 61 30 26 1314.0BGLAP, CAV1
11glutamate458.9NUDT6, MYH7, CAV1
12testosterone45 61 26 1311.8BGLAP, NUDT6, CAV1
13atp45 309.8CAV1, MYH7, NUDT6
14vegf458.8CAV1, NUDT6, BGLAP
15retinoic acid45 269.3CAV1, NUDT6, BGLAP
16arginine458.3BGLAP, NUDT6, MYH7, CAV1
17cysteine458.3BGLAP, NUDT6, MYH7, CAV1
18serine458.2BGLAP, NUDT6, MYH7, CAV1
19calcium45 51 26 1310.5CAV1, PCOLCE, MYH2, MYH7, NUDT6, BGLAP

GO Terms for genes affiliated with Bone Fracture

About this section

Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:00300179.4MYH2, MYH7
2muscle myosin complexGO:00058599.3MYH2, MYH7
3myosin filamentGO:00329829.1MYH2, MYH7

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:00069369.4MYH2, MYH7
2muscle filament slidingGO:00300499.3MYH2, MYH7
3response to activityGO:00148239.2MYH2, BGLAP
4response to estrogenGO:00436278.8CAV1, BGLAP

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activator activityGO:00165049.5CAV1, PCOLCE
2microfilament motor activityGO:00001469.3MYH2, MYH7
3structural molecule activityGO:00051989.1CAV1, BGLAP
4calmodulin bindingGO:00055169.1MYH2, MYH7

Products for genes affiliated with Bone Fracture

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Bone Fracture

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet