MCID: BNF002
MIFTS: 45

Bone Fracture malady

Bone diseases category

Summaries for Bone Fracture

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards: Bone Fracture is related to prostate cancer and osteoporosis. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are RhoGDI Pathway and Clathrin derived vesicle budding. The compounds (r)-(+)-blebbistatin and bts have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and spinal cord.

Aliases & Classifications for Bone Fracture

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Sources:
32LifeMap Discoveryā„¢, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone fracture 32 46


Related Diseases for Bone Fracture

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Symptoms for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bone Fracture

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Search CenterWatch for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Bone Fracture:

34
Bone, Liver, Spinal cord, Brain, Breast, Bone marrow, Prostate, Kidney, Skeletal muscle, Thyroid, Eye, Lymph node, Lung, Cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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Publications for Bone Fracture

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Sources:
53PubMed
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Articles related to Bone Fracture:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)
2013
2
Circuit modeling of the electrical impedance: part III. Disuse following bone fracture. (23587651)
2013
3
Estimation of 10-year probability bone fracture in a selected sample of Palestinian people using fracture risk assessment tool. (24093559)
2013
4
Development of an ex vivo protocol to model bone fracture in laying hens resulting from collisions. (23785487)
2013
5
Bone fracture exacerbates murine ischemic cerebral injury. (23438676)
2013
6
Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing. (23937065)
2013
7
Clinical Feasibility of Multiplanar Reconstruction Images of Temporal Bone CT in the Diagnosis of Temporal Bone Fracture with Otic-Capsule-Sparing Facial Nerve Paralysis. (24427570)
2013
8
3D identification of trabecular bone fracture zone using an automatic image registration scheme: A validation study. (22682259)
2012
9
Cochlear implantation in posttraumatic bilateral temporal bone fracture. (22328130)
2012
10
Role of mathematical modeling in bone fracture healing. (24228159)
2012
11
A comparative study of emergence agitation between sevoflurane and propofol anesthesia in adults after closed reduction of nasal bone fracture. (22870365)
2012
12
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. (21507568)
2011
13
Mechanisms of hyoid bone fracture after modelling: evaluation of anthropological criteria defining two relevant models. (21764532)
2011
14
Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. (20445964)
2011
15
A new approach to the treatment of nasal bone fracture: radiologic classification of nasal bone fractures and its clinical application. (21474225)
2011
16
Extranasal splint made of a polyethylene container: a distinct fixation method after nasal bone fracture reduction surgery. (21788804)
2011
17
A new approach to the treatment of nasal bone fracture: the clinical usefulness of closed reduction using a C-arm. (21317053)
2011
18
Bone, fracture and frailty. (21537171)
2011
19
Bone mineral density and bone fracture in male patients receiving long-term suppressive levothyroxine treatment for differentiated thyroid carcinoma. (20960170)
2010
20
Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. (20855498)
2010
21
Disseminated tuberculosis complicated with tuberculous meningitis, miliary tuberculosis, and thoracal bone fracture while investigating a cervical lymphadenopathy. Tuberculosis: a hidden enemy? (20672504)
2010
22
Comparison of the frequency of old septal deviation in patients with and without traumatic nasal bone fracture. (21287462)
2010
23
Time-frequency analysis to detect bone fracture in impact biomechanics. Application to the thorax. (19540145)
2009
24
Multiple bone fracture due to Fanconi's syndrome in primary SjAPgren's syndrome complicated with organizing pneumonia. (19363610)
2009
25
Ultrasonic monitoring of bone fracture healing. (18599412)
2008
26
Temporal bone fracture with ossicular dislocation caused by a blow to the opposite side of the head. (17826019)
2008
27
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. (17950532)
2007
28
Assessing the risk of bone fracture among postmenopausal women who are receiving adjuvant hormonal therapy for breast cancer. (17519070)
2007
29
Effect of long tubular bone fracture on serum levels of leptin, acute phase proteins and biochemical markers for organ functions]. (16464379)
2006
30
Assessment of stiffness and strength of 4 different implants available for equine fracture treatment: a study on a 20 degrees oblique long-bone fracture model using a bone substitute. (16115079)
2005
31
Hyoid bone fracture from a gunshot wound. (15284578)
2004
32
Obscure temporal bone fracture with conductive hearing loss. (12619459)
2003
33
Pneumolabyrinth: an unusual finding in a temporal bone fracture. (12697360)
2003
34
Efficacy of monitoring long-bone fracture healing by measurement of either bone stiffness or resonant frequency: numerical simulation. (11117288)
2000
35
Is exposure to HMG-CoA reductase inhibitors (statins), fibrates, or other lipid-lowering drugs associated with reduced risk of bone fracture in older patients? (11032211)
2000
36
Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer. (10971270)
2000
37
The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. (10027889)
1999
38
An interspecies comparison of bone fracture properties. (9713681)
1998
39
Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. (8231848)
1993
40
Principles of long bone fracture management. (1570435)
1992
41
Air in the temporomandibular joint fossa: CT sign of temporal bone fracture. (2068313)
1991
42
Electrostimulation and bone fracture healing. (2004532)
1991
43
The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. (2125994)
1990
44
Histopathology of the facial nerve after longitudinal temporal bone fracture. (3386375)
1988
45
Pneumolabyrinth as a late sequela of temporal bone fracture. (3232721)
1988
46
Retardation of bone fracture healing in experimental diabetes. (3623654)
1987
47
A cumulative damage model for bone fracture. (3981298)
1985
48
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat. (6202957)
1984
49
The effects of pulsed magnetic fields of the type used in the stimulation of bone fracture healing. (6339155)
1983
50
Bilateral transverse temporal bone fracture: case report. (6038406)
1967

Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 61Thomson Reuters, 31KEGG
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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4MYH2, MYH7
2
Show member pathways
9.4MYH2, MYH7
3
Show member pathways
9.4MYH2, MYH7
49.4MYH7, MYH2
5
Show member pathways
8.9MYH2, NUDT6, MYH7
6
Show member pathways
8.9NUDT6, MYH7, MYH2
7
Show member pathways
8.9CAV1, MYH2, MYH7
8
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
8.9MYH7, MYH2, CAV1

Compounds for genes affiliated with Bone Fracture

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Sources:
62Tocris Bioscience, 46Novoseek, 30IUPHAR, 3BitterDB, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1(r)-(+)-blebbistatin629.7MYH7, MYH2
2bts629.7MYH7, MYH2
3(s)-(-)-blebbistatin629.7MYH7, MYH2
4(+-)-blebbistatin629.7MYH7, MYH2
5actomyosin469.7MYH2, MYH7
6gp 130469.5CAV1, MYH7
7procollagen469.5PCOLCE, BGLAP
8bromodeoxyuridine469.3MYH7, NUDT6
9caffeine46 30 3 52 25 1214.2NUDT6, BGLAP
10simvastatin46 52 62 30 25 1214.0BGLAP, CAV1
11glutamate468.9NUDT6, MYH7, CAV1
12testosterone46 62 25 1211.8BGLAP, NUDT6, CAV1
13atp46 309.8CAV1, MYH7, NUDT6
14vegf468.8CAV1, NUDT6, BGLAP
15retinoic acid46 259.3CAV1, NUDT6, BGLAP
16arginine468.3BGLAP, NUDT6, MYH7, CAV1
17cysteine468.3BGLAP, NUDT6, MYH7, CAV1
18serine468.2BGLAP, NUDT6, MYH7, CAV1
19calcium46 52 25 1210.5CAV1, PCOLCE, MYH2, MYH7, NUDT6, BGLAP

GO Terms for genes affiliated with Bone Fracture

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Sources:
17Gene Ontology
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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.4MYH2, MYH7
2muscle myosin complexGO:0058599.3MYH2, MYH7
3myosin filamentGO:0329829.1MYH2, MYH7

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:0069369.4MYH2, MYH7
2muscle filament slidingGO:0300499.3MYH2, MYH7
3response to activityGO:0148239.2MYH2, BGLAP
4response to estrogenGO:0436278.8CAV1, BGLAP

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activator activityGO:0165049.5CAV1, PCOLCE
2microfilament motor activityGO:0001469.3MYH2, MYH7
3structural molecule activityGO:0051989.1CAV1, BGLAP
4calmodulin bindingGO:0055169.1MYH2, MYH7

Products for genes affiliated with Bone Fracture

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Fracture

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet