Aliases & Classifications for Bone Fracture

MalaCards integrated aliases for Bone Fracture:

Name: Bone Fracture 37 51

Classifications:



Summaries for Bone Fracture

MalaCards based summary : Bone Fracture is related to osteofibrous dysplasia and osteoporosis. An important gene associated with Bone Fracture is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are GPCR Pathway and ERK Signaling. The drugs Teriparatide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

Related Diseases for Bone Fracture

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 osteofibrous dysplasia 31.7 BGLAP BMP2 TGFB1
2 osteoporosis 30.0 BGLAP BMP2 CRP LRP5 TGFB1
3 spinal muscular atrophy, type i, with congenital bone fractures 12.4
4 spinal muscular atrophy with congenital bone fractures 2 12.3
5 prenatal-onset spinal muscular atrophy with congenital bone fractures 12.0
6 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.2
7 antley-bixler syndrome 11.0
8 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 11.0
9 hyper-ige recurrent infection syndrome, autosomal dominant 10.9
10 gnathodiaphyseal dysplasia 10.9
11 osteogenesis imperfecta, type i 10.8
12 mucolipidosis iii alpha/beta 10.8
13 multiple pterygium syndrome, lethal type 10.8
14 osteoporosis-pseudoglioma syndrome 10.8
15 pyle disease 10.8
16 spinal muscular atrophy, x-linked 2 10.8
17 neuropathy, hereditary sensory and autonomic, type v 10.8
18 cerebroretinal microangiopathy with calcifications and cysts 1 10.8
19 neuropathy, hereditary sensory and autonomic, type vii 10.8
20 bruck syndrome 10.8
21 rickets 10.8
22 tetanus 10.8
23 osteitis fibrosa 10.8
24 cerebrospinal fluid leak 10.8
25 aortic valve disease 1 10.3 BMP2 CRP TGFB1
26 glanders 10.3 LRP5 TLR4
27 intestinal disease 10.3 CRP STAT3 TLR4
28 eosinophilic variant of chromophobe renal cell carcinoma 10.3 CAV1 TGFB1
29 diabetic foot ulcers 10.3 CRP TGFB1
30 camurati-engelmann disease 10.3 BGLAP LRP5 TGFB1
31 variola major 10.3 IL2 TLR4
32 bone resorption disease 10.3 BGLAP BMP2 LRP5
33 aortic valve disease 2 10.2 BMP2 CRP MYH7
34 bone remodeling disease 10.2 BGLAP BMP2 LRP5
35 periodontitis 10.2 BGLAP CRP TLR4
36 virus associated hemophagocytic syndrome 10.2 IL2 MB
37 tympanosclerosis 10.2 BMP2 TLR4
38 brucellosis 10.2 CRP IL2 TLR4
39 bone mineral density quantitative trait locus 8 10.1
40 bone mineral density quantitative trait locus 15 10.1
41 primary bacterial infectious disease 10.1 CRP IL2 TLR4
42 heritable pulmonary arterial hypertension 10.1 CAV1 TGFB1
43 chagas disease 10.0 IL2 TGFB1 TLR4
44 facial paralysis 10.0
45 episodic pain syndrome, familial, 1 10.0
46 aging 10.0
47 visceral leishmaniasis 10.0 CRP IL2 TLR4
48 leukocyte disease 9.9 CRP IL2 IL3
49 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
50 cerebritis 9.9

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to Bone Fracture

Symptoms & Phenotypes for Bone Fracture

MGI Mouse Phenotypes related to Bone Fracture:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
2 cellular MP:0005384 10.11 FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
3 hematopoietic system MP:0005397 10.06 FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
4 liver/biliary system MP:0005370 9.86 STAT3 IL2 TGFB1 LRP5 LTBP1 CAV1
5 muscle MP:0005369 9.85 FGF2 STAT3 TGFB1 LTBP1 CAV1 MB
6 neoplasm MP:0002006 9.43 FGF2 STAT3 IL2 TGFB1 CAV1 TLR4
7 skeleton MP:0005390 9.32 FGF2 STAT3 TGFB1 LRP5 BMP2 LTBP1

Drugs & Therapeutics for Bone Fracture

Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 686)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52232-67-4 16133850
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
4
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
5
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
6
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
7
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 27262-47-1 92253
8
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
9
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1 84057-95-4 175805 71273
10
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 471-34-1
11
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
12
Thrombin Approved, Investigational Phase 4
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
14
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
15
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
16
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
17
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
18
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 76-42-6 5284603
19 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 329-65-7
20
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
21
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
22
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
23
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
24
Linagliptin Approved Phase 4 668270-12-0 10096344
25
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
26
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 1 112809-51-5 3902
27
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
28
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
29
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
30
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
31
Etomidate Approved Phase 4 33125-97-2 667484 36339
32
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
33
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
35
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 437-38-7 3345
36
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
37
Indapamide Approved Phase 4 26807-65-8 3702
38
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
39
Tramadol Approved, Investigational Phase 4,Phase 2 27203-92-5 33741
40
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206
41
Desflurane Approved Phase 4 57041-67-5 42113
42
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
43
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
45
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
46
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 46507594 772
47
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Early Phase 1 15687-27-1 3672
48
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
49
Ethanol Approved Phase 4 64-17-5 702
50
Alendronate Approved Phase 4,Phase 3,Phase 2,Phase 1 121268-17-5, 66376-36-1 2088

Interventional clinical trials:

(show top 50) (show all 2893)

# Name Status NCT ID Phase Drugs
1 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
2 The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures Unknown status NCT01173081 Phase 4 Teriparatide;Placebo
3 Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
4 NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures Unknown status NCT00969839 Phase 4
5 Parathyroid Hormone for the Treatment of Humerus Fractures Unknown status NCT01687374 Phase 4 1-84 parathyroid hormone;Placebo
6 Single Dose of Dexamethasone in Femur Fractures Unknown status NCT01550146 Phase 4 Dexamethasone acetate;Placebo
7 Hematoma Block for Reduction of Distal Radius Fractures Unknown status NCT02129270 Phase 4 Lidocaine HCl 2% .;Lidocaine HCl 1%
8 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
9 The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery Unknown status NCT00162617 Phase 4 Red blood cell transfusion
10 Fast Track Admittance of Hip Fracture Patients Unknown status NCT00345488 Phase 4
11 Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture Unknown status NCT01509859 Phase 4
12 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
13 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4 Iron sucrose
14 Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures Unknown status NCT02580227 Phase 4 Tranexamic Acid
15 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4 Levobupivacaine
16 Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Unknown status NCT02104908 Phase 4
17 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
18 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
19 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
20 Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw Unknown status NCT01219088 Phase 4 Bupivacaine, morphine
21 Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis Unknown status NCT00941213 Phase 4
22 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4 periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
23 Deep Neuromuscular Block on Cytokines Release and Postoperative Delirium Unknown status NCT02507609 Phase 4
24 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
25 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
26 A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers Unknown status NCT02429232 Phase 4 Pioglitazone;Linagliptin
27 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole
28 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4 zoledronic acid;sodium chloride
29 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
30 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
31 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
32 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
33 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
34 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
35 Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics Unknown status NCT02389179 Phase 4 Vitamin D3
36 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
37 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
38 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4 intravenous fentanyl;intra-nasal fentanyl
39 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
40 Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors Unknown status NCT00111241 Phase 4 aromatase inhibitors (letrozole, anastrozole)
41 The Hypertension in the Very Elderly Trial (HYVET) Unknown status NCT00122811 Phase 4 Indapamide SR 1.5mg; Perindopril 2-4mg
42 Study Evaluating InductOs in Diaphyseal Tibia Fractures Completed NCT00161616 Phase 4 InductOs
43 Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants Completed NCT01431560 Phase 4
44 Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate Completed NCT01437150 Phase 4
45 Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures Completed NCT00552331 Phase 4
46 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
47 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4
48 RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child Completed NCT00560443 Phase 4 ketorolac;tramadol
49 Effect of Anesthesia in Fracture Healing Completed NCT02621255 Phase 4 Sevoflurane;Bupivacaine
50 Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture Completed NCT00824564 Phase 4 Tranexamic Acid plus standard of care

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

Anatomical Context for Bone Fracture

MalaCards organs/tissues related to Bone Fracture:

38
Bone, Breast, Prostate, Bone Marrow, Kidney, Spinal Cord, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Bone Fracture

Articles related to Bone Fracture:

(show top 50) (show all 694)
# Title Authors Year
1
Mineralized collagen fibril network spatial arrangement influences cortical bone fracture behavior. ( 29137726 )
2018
2
Hypophosphatemic Osteomalacia with Multiple Bone Fractures: ADV-Induced Fanconi's Syndrome. ( 29399572 )
2018
3
Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )
2018
4
Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression. ( 29383945 )
2018
5
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. ( 29146294 )
2018
6
The Impact of Type 2 Diabetes on Bone Fracture Healing. ( 29416527 )
2018
7
Estrogen receptor I+- (ERI+), but not ERI^-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration. ( 29367057 )
2018
8
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. ( 29356996 )
2018
9
Pain Intensity and Risk of Bone Fracture in Children With Minor Extremity Injuries. ( 29369266 )
2018
10
Regenerate bone fracture rate following femoral lengthening in paediatric patients. ( 28828065 )
2017
11
Convex bone deformity after closed reduction of nasal bone fracture. ( 28918998 )
2017
12
Epidemiology of Bone Fracture in Female Trauma Patients Based on Risks of Osteoporosis Assessed using the Osteoporosis Self-Assessment Tool for Asians Score. ( 29137199 )
2017
13
Occurrence of Clinical Bone Fracture Following a Prolonged Stay in Intensive Care Unit: A Retrospective Controlled Study. ( 28695239 )
2017
14
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes. ( 28924381 )
2017
15
Improving the human-robot interface for telemanipulated robotic long bone fracture reduction: Joystick device vs. haptic manipulator. ( 28948678 )
2017
16
Analysis of Facial Symmetry After Zygomatic Bone Fracture Management. ( 29121488 )
2017
17
A Rare Case of Infantile Myofibromatosis Presenting to the Emergency Department as Undiagnosed Long Bone Fractures. ( 29095782 )
2017
18
Delayed Expression of Circulating TGF-I^1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing. ( 28331138 )
2017
19
Factors related to infection after fixation in the process of late healed bone fracture. ( 28810567 )
2017
20
Objective Outcomes of Closed Reduction According to the Type of Nasal Bone Fracture. ( 28913300 )
2017
21
Reliability of temporal bone high-resolution CT in patients with facial paralysis in temporal bone fracture. ( 29258690 )
2017
22
The interplay of transcriptional and post-transcriptional regulation of migration of mesenchymal stem cells during early stages of bone fracture healing. ( 29271984 )
2017
23
STAT3 promotes bone fracture healing by enhancing the FOXP3 expression and the suppressive function of regulatory T cells. ( 28493494 )
2017
24
Impairment of cold injury-induced muscle regeneration in mice receiving a combination of bone fracture and alendronate treatment. ( 28715470 )
2017
25
Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study. ( 27836732 )
2017
26
The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing. ( 28677081 )
2017
27
Association between metabolic syndrome and bone fracture risk: A community-based study using a fracture risk assessment tool. ( 29390327 )
2017
28
Pathological bone fractures in a patient with parathyroid carcinoma - A Case Report. ( 29256556 )
2017
29
Spinal Reorganization after Bone Fracture in Mice. ( 28062308 )
2017
30
The Algorithm-Oriented Management of Nasal Bone Fracture according to Stranc's Classification System. ( 28913315 )
2017
31
Actual reason for bone fractures in the case of a patient followed-up with the osteogenesis imperfecta: Gaucher's Disease. ( 29354164 )
2017
32
Correlation between Operation Result and Patient Satisfaction of Nasal Bone Fracture. ( 28913299 )
2017
33
Olfactory Dysfunction in Nasal Bone Fracture. ( 28913314 )
2017
34
The effects of dipeptidyl peptidase-4 inhibitors on bone fracture among patients with type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials. ( 29206832 )
2017
35
Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity. ( 28777474 )
2017
36
Non-union bone fracture: a quicker fix. ( 29069072 )
2017
37
Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. ( 28885321 )
2017
38
Using temporal bone computed tomography to predict sensorineural hearing loss in otic capsule-sparing temporal bone fracture. ( 29096926 )
2017
39
Study of fall risk-increasing drugs in elderly patients before and after a bone fracture. ( 28916557 )
2017
40
Preliminary results of vibro-acoustography evaluation of bone surface and bone fracture. ( 29184767 )
2017
41
An Algorithmic Approach Using Ultrasonography in the Diagnosis of Pediatric Nasal Bone Fracture. ( 27906845 )
2017
42
The effect of light-emitting diode (590/830A nm)-based low-level laser therapy on posttraumatic edema of facial bone fracture patients. ( 28986000 )
2017
43
In vivo study of microarc oxidation coated biodegradable magnesium plate to heal bone fracture defect of 3mm width. ( 28688364 )
2017
44
A novel etiology for pneumolabyrinth after temporal bone fracture without otic capsule involvement. ( 29121383 )
2017
45
A review of computational models of bone fracture healing. ( 28785849 )
2017
46
Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. ( 29070810 )
2017
47
Customized titanium mesh based on the 3D printed model vs. manual intraoperative bending of titanium mesh for reconstructing of orbital bone fracture: a randomized clinical trial. ( 28828975 )
2017
48
Computer assisted preoperative planning of bone fracture reduction: Simulation techniques and new trends. ( 26849422 )
2016
49
Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )
2016
50
Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovariectomy-induced osteoporotic rats. ( 27155884 )
2016

Variations for Bone Fracture

Expression for Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for Bone Fracture

Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
2
Show member pathways
13.5 BMP2 FGF2 IL2 IL3 LRP5 LTBP1
3
Show member pathways
13.49 BMP2 CRP FGF2 IL2 IL3 LTBP1
4
Show member pathways
13.47 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
5
Show member pathways
13.26 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
6
Show member pathways
13.25 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
7
Show member pathways
13.17 BMP2 CAV1 FGF2 IL2 IL3 LTBP1
8
Show member pathways
12.92 BMP2 FGF2 IL2 IL3 LTBP1 MYH2
9
Show member pathways
12.81 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
10
Show member pathways
12.79 CAV1 IL2 IL3 MYH7 TGFB1
11
Show member pathways
12.68 BMP2 FGF2 LTBP1 PCOLCE TGFB1
12 12.63 BMP2 FGF2 IL2 IL3 LRP5 STAT3
13
Show member pathways
12.49 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
14
Show member pathways
12.42 BMP2 FGF2 MYH7 TGFB1
15 12.18 CAV1 FGF2 STAT3 TGFB1 TLR4
16 12.14 LRP5 STAT3 TGFB1 TLR4
17
Show member pathways
12.11 FGF2 LRP5 STAT3 TGFB1
18 12.02 FGF2 IL3 STAT3 TGFB1
19 11.88 BMP2 IL3 TGFB1
20
Show member pathways
11.85 IL2 STAT3 TGFB1 TLR4
21
Show member pathways
11.84 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
22 11.81 IL2 TGFB1 TLR4
23
Show member pathways
11.81 STAT3 TGFB1 TLR4
24 11.79 BGLAP BMP2 FGF2 TGFB1
25 11.78 FGF2 TGFB1 TGFBR3
26 11.75 BMP2 LTBP1 TGFB1
27
Show member pathways
11.75 STAT3 TGFB1 TGFBR3 TLR4
28 11.69 LRP5 TGFB1 TLR4
29
Show member pathways
11.68 BMP2 LTBP1 TGFB1
30 11.51 CAV1 TGFB1 TGFBR3
31 11.49 FGF2 TGFB1 TGFBR3
32 11.47 FGF2 IL3 TGFB1
33 11.47 LTBP1 STAT3 TGFB1 TGFBR3
34 11.42 BGLAP STAT3 TGFB1
35 11.21 IL2 IL3 TGFB1
36 11.17 IL2 STAT3 TGFB1
37 10.88 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6

GO Terms for Bone Fracture

Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BGLAP BMP2 CRP CRTAC1 FGF2 IL2
2 extracellular space GO:0005615 9.32 BGLAP BMP2 CRP FGF2 IL2 IL3

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.92 FGF2 IL2 IL3 TGFB1
2 inflammatory response GO:0006954 9.88 BMP2 CRP STAT3 TGFB1 TLR4
3 positive regulation of cell proliferation GO:0008284 9.88 FGF2 IL2 IL3 LRP5 STAT3 TGFB1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 BMP2 FGF2 TGFB1 TLR4
5 regulation of receptor activity GO:0010469 9.8 BMP2 FGF2 IL2 IL3 NUDT6 TGFB1
6 BMP signaling pathway GO:0030509 9.77 BMP2 TGFB1 TGFBR3
7 cellular response to organic cyclic compound GO:0071407 9.74 BMP2 STAT3 TGFB1
8 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 CAV1 TGFB1 TGFBR3
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 IL2 IL3 STAT3
10 somatic stem cell population maintenance GO:0035019 9.71 FGF2 LRP5 STAT3
11 cellular response to growth factor stimulus GO:0071363 9.69 BGLAP BMP2 TGFB1
12 hyaluronan catabolic process GO:0030214 9.64 FGF2 TGFB1
13 regulation of regulatory T cell differentiation GO:0045589 9.63 IL2 TGFB1
14 positive regulation of superoxide anion generation GO:0032930 9.63 CRP TGFB1
15 positive regulation of gene expression GO:0010628 9.63 BMP2 CAV1 CRP STAT3 TGFB1 TLR4
16 cardiac epithelial to mesenchymal transition GO:0060317 9.62 BMP2 TGFBR3
17 positive regulation of interleukin-17 production GO:0032740 9.61 IL2 TGFB1
18 positive regulation of peptidase activity GO:0010952 9.61 CAV1 PCOLCE
19 epithelial to mesenchymal transition GO:0001837 9.61 BMP2 TGFB1 TGFBR3
20 positive regulation of osteoblast proliferation GO:0033690 9.59 BMP2 LRP5
21 negative regulation of interleukin-17 production GO:0032700 9.58 TGFB1 TLR4
22 positive regulation of regulatory T cell differentiation GO:0045591 9.58 IL2 TGFB1
23 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.54 MYH7 TGFB1 TGFBR3
24 positive regulation of odontogenesis GO:0042482 9.46 BMP2 TGFB1
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.43 BMP2 STAT3 TGFB1
26 response to hypoxia GO:0001666 9.35 BMP2 CAV1 MB TGFB1 TGFBR3
27 pathway-restricted SMAD protein phosphorylation GO:0060389 8.8 BMP2 TGFB1 TGFBR3
28 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 BMP2 FGF2 IL2 LRP5 STAT3 TGFB1

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activator activity GO:0016504 9.37 CAV1 PCOLCE
2 cytokine activity GO:0005125 9.35 BMP2 FGF2 IL2 IL3 TGFB1
3 transforming growth factor beta receptor binding GO:0005160 9.33 BMP2 TGFB1 TGFBR3
4 type II transforming growth factor beta receptor binding GO:0005114 9.32 TGFB1 TGFBR3
5 transforming growth factor beta-activated receptor activity GO:0005024 9.26 LTBP1 TGFBR3
6 growth factor activity GO:0008083 9.1 BMP2 FGF2 IL2 IL3 NUDT6 TGFB1

Sources for Bone Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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