Bone Fracture disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Bone Fracture

Sources:
⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards based summary: Bone Fracture is related to prostate cancer and osteoporosis. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are RhoGDI Pathway and Clathrin derived vesicle budding. The compounds (r)-(+)-blebbistatin and bts have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord.

Aliases & Classifications for Bone Fracture

Sources:
³¹LifeMap Discovery®, ⁴⁴Novoseek
See all sources

Bone Fracture, Aliases & Descriptions:

Name: Bone Fracture ³¹ ⁴⁴

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases

Related Diseases for Bone Fracture

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 94)

id	Related Disease	Score	Top Affiliating Genes
1	prostate cancer	29.6	BGLAP, NUDT6, CAV1
2	osteoporosis	10.5
3	facial paralysis	10.4
4	spinal muscular atrophy type 1 with congenital bone fractures	10.3
5	obesity	10.2
6	brain injury	10.2
7	hepatitis	10.2
8	cervicitis	10.2
9	hyperparathyroidism	10.2
10	meningitis	10.2
11	neuropathy	10.2
12	diabetes mellitus	10.1
13	hepatocellular carcinoma	10.1
14	traumatic brain injury	10.1
15	pharyngitis	10.1
16	cerebrotendinous xanthomatosis	10.1
17	primary hyperparathyroidism	10.1
18	cerebritis	10.1
19	breast cancer	10.1
20	hypogonadism	10.1
21	prostatitis	10.1
22	tuberculosis	10.1
23	xanthomatosis	10.1
24	head injury	10.1
25	pituitary tumors	10.1	NUDT6, CAV1
26	pituitary adenoma	10.1	CAV1, NUDT6
27	lung small cell carcinoma	10.0	CAV1, NUDT6
28	noonan syndrome	10.0	CAV1, MYH7
29	bone cancer	10.0	CAV1, BGLAP
30	myopathy	10.0	MYH2, MYH7
31	aneurysmal bone cysts	9.9
32	celiac disease	9.9
33	cerebral palsy	9.9
34	craniosynostosis	9.9
35	hepatitis b	9.9
36	hiv-1	9.9
37	hodgkin's lymphoma	9.9
38	leukemia	9.9
39	liver cirrhosis	9.9
40	liver disease	9.9
41	morbid obesity	9.9
42	multiple myeloma	9.9
43	myocardial infarction	9.9
44	pseudoarthrosis	9.9
45	spinal cord injury	9.9
46	spinal muscular atrophy	9.9
47	systemic mastocytosis	9.9
48	type 2 diabetes mellitus	9.9
49	antley-bixler syndrome	9.9
50	hepatitis c	9.9

Graphical network of the top 20 diseases related to Bone Fracture:

$Diseases related to bone fracture$

Symptoms for Bone Fracture

Drugs & Therapeutics for Bone Fracture

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ³¹LifeMap Discovery®, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:

The database of embryonic development, stem cell research and regenerative medicine

Read about Bone Fracture cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Bone Fracture:

	Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
	Ovation
	Stromal vascular fraction cells for osteoporotic bone fractures

Embryonic/Adult Cultured Cells Related to Bone Fracture:

	Bone marrow-derived mesenchymal stem cells, PMID: 23180104
	Stromal vascular fraction cells, PMIDs: 21605897, 16488036

Genetic Tests for Bone Fracture

Anatomical Context for Bone Fracture

Sources:
³¹LifeMap Discovery®, ³²MalaCards
See all sources

MalaCards organs/tissues related to Bone Fracture:

³²

Bone, Brain, Spinal cord, Liver, Breast, Bone marrow, Skeletal muscle, Kidney, Prostate, Eye, Lymph node, Cortex, Lung, Thyroid, Testes, Endothelial

The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:

id	TissueAnatomical CompartmentCell	Relevance
1	AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells	Potential therapeutic candidate
2	AdiposeSubcutaneous White AdiposeStromal Cells	Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

Publications for Bone Fracture

Sources:
⁵¹PubMed
See all sources

Articles related to Bone Fracture:

(show top 50) (show all 540)

id	Title	Authors	Year
1	Plasma homocysteine, B vitamins and bone mineral density in osteoporosis: a possible risk for bone fracture. (25335377)	Ebesunun M.O.... Adebusoye L.A.	2014
2	The relationship between patient age and pain management of acute long-bone fracture in the ED. (25312220)	Boccio E.... D'Amore J.	2014
3	Comparison study of the use of absorbable and nonabsorbable materials as internal splints after closed reduction for nasal bone fracture. (25075356)	Yi C.R.... Choi Y.W.	2014
4	Bone Fracture Toughness and Strength Correlate with Collagen Cross-Link Maturity in a Dose-Controlled Lathyrism Mouse Model. (25213475)	McNerny E.M.... Kohn D.H.	2014
5	Temporal bone fracture causing superior semicircular canal dehiscence. (25295207)	Peng K.A.... Gopen Q.	2014
6	Bone fracture healing: Cell therapy in delayed unions and nonunions. (25093266)	GA^mez-Barrena E.... Gerbhard F.	2014
7	Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)	Do B.H.... Biswal S.	2013
8	Circuit modeling of the electrical impedance: part III. Disuse following bone fracture. (23587651)	Shiffman C.A.	2013
9	Estimation of 10-year probability bone fracture in a selected sample of Palestinian people using fracture risk assessment tool. (24093559)	Aker M.B.... Sweileh W.M.	2013
10	Development of an ex vivo protocol to model bone fracture in laying hens resulting from collisions. (23785487)	Toscano M.J.... Tarlton J.F.	2013
11	Bone fracture exacerbates murine ischemic cerebral injury. (23438676)	Degos V.... Su H.	2013
12	Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing. (23937065)	Wang Y.H.... Karaplis A.	2013
13	3D identification of trabecular bone fracture zone using an automatic image registration scheme: A validation study. (22682259)	Tassani S.... Baruffaldi F.	2012
14	Cochlear implantation in posttraumatic bilateral temporal bone fracture. (22328130)	Vermeire K.... Van de Heyning P.H.	2012
15	Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. (21507568)	Espinosa P.S.... Ryan M.	2011
16	Mechanisms of hyoid bone fracture after modelling: evaluation of anthropological criteria defining two relevant models. (21764532)	Pollard J.... Leonetti G.	2011
17	Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. (20445964)	Kuruvilla K.... Rajan T.V.	2011
18	A new approach to the treatment of nasal bone fracture: radiologic classification of nasal bone fractures and its clinical application. (21474225)	Han D.S.... Park J.H.	2011
19	Extranasal splint made of a polyethylene container: a distinct fixation method after nasal bone fracture reduction surgery. (21788804)	Li T.S.... Chung K.C.	2011
20	A new approach to the treatment of nasal bone fracture: the clinical usefulness of closed reduction using a C-arm. (21317053)	Han D.S.... Park J.H.	2011
21	Bone mineral density and bone fracture in male patients receiving long-term suppressive levothyroxine treatment for differentiated thyroid carcinoma. (20960170)	Reverter J.L.... SanmartA- A.	2010
22	Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. (20855498)	Matsumoto T.... Asahara T.	2010
23	Disseminated tuberculosis complicated with tuberculous meningitis, miliary tuberculosis, and thoracal bone fracture while investigating a cervical lymphadenopathy. Tuberculosis: a hidden enemy? (20672504)	Aslan S.... Atalay B.	2010
24	Comparison of the frequency of old septal deviation in patients with and without traumatic nasal bone fracture. (21287462)	Behnoud F.... Alizamir A.	2010
25	Time-frequency analysis to detect bone fracture in impact biomechanics. Application to the thorax. (19540145)	Gabrielli F.... Masson C.	2009
26	Ultrasonic monitoring of bone fracture healing. (18599412)	Protopappas V.C.... Malizos K.N.	2008
27	Temporal bone fracture with ossicular dislocation caused by a blow to the opposite side of the head. (17826019)	Chujo K.... Komune S.	2008
28	Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. (17950532)	Martin C.D.... Mantyh P.W.	2007
29	Assessing the risk of bone fracture among postmenopausal women who are receiving adjuvant hormonal therapy for breast cancer. (17519070)	Bell R.... Lewis J.	2007
30	Effect of long tubular bone fracture on serum levels of leptin, acute phase proteins and biochemical markers for organ functions]. (16464379)	Lin J.... Zhang K.	2006
31	Obscure temporal bone fracture with conductive hearing loss. (12619459)	Deguine C.... Pulec J.L.	2003
32	Pneumolabyrinth: an unusual finding in a temporal bone fracture. (12697360)	Gross M.... Eliashar R.	2003
33	Efficacy of monitoring long-bone fracture healing by measurement of either bone stiffness or resonant frequency: numerical simulation. (11117288)	Roberts S.G.... Steele C.R.	2000
34	Is exposure to HMG-CoA reductase inhibitors (statins), fibrates, or other lipid-lowering drugs associated with reduced risk of bone fracture in older patients? (11032211)	Douglas L.O.	2000
35	Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer. (10971270)	Hatano T.... Tashiro K.	2000
36	The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. (10027889)	Lin F.H.... Lee C.J.	1999
37	Vitamin D receptor genotype and the risk of bone fractures in women. (9730033)	Feskanich D.... Colditz G.A.	1998
38	An interspecies comparison of bone fracture properties. (9713681)	Wang X.... Agrawal C.M.	1998
39	Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. (8231848)	Kuriyama M.... Osame M.	1993
40	Principles of long bone fracture management. (1570435)	Boudrieau R.J.... Sinibaldi K.R.	1992
41	Air in the temporomandibular joint fossa: CT sign of temporal bone fracture. (2068313)	Betz B.W.... Wiener M.D.	1991
42	Electrostimulation and bone fracture healing. (2004532)	Behari J.	1991
43	The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. (2125994)	Ohmori T.... Shibata T.	1990
44	Histopathology of the facial nerve after longitudinal temporal bone fracture. (3386375)	Eby T.L.... Fisch U.	1988
45	Pneumolabyrinth as a late sequela of temporal bone fracture. (3232721)	Nurre J.W.... Ball J.B.	1988
46	Retardation of bone fracture healing in experimental diabetes. (3623654)	Dixit P.K.... Ekstrom R.A.	1987
47	A cumulative damage model for bone fracture. (3981298)	Carter D.R.... Caler W.E.	1985
48	Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat. (6202957)	Miller B.M.... Abumrad N.N.	1984
49	The effects of pulsed magnetic fields of the type used in the stimulation of bone fracture healing. (6339155)	Barker A.T.... Lunt M.J.	1983
50	Bilateral transverse temporal bone fracture: case report. (6038406)	Glasgold A.... Pantoja E.	1967

Genes related to Bone Fracture

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Bone Fracture:

- Elite gene

id	Symbol	Description	Score	Implication
1	PCOLCE	procollagen C-endopeptidase enhancer	21.66	GeneCards inferred via : Publications (show sections)
2	MYH2	myosin, heavy chain 2, skeletal muscle, adult	18.33	GeneCards inferred via : Publications (show sections)
3	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	14.99	GeneCards inferred via : Publications (show sections)
4	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.66	GeneCards inferred via : Publications (show sections)
5	BGLAP	bone gamma-carboxyglutamate (gla) protein	8.33	GeneCards inferred via : Publications (show sections)
6	CAV1	caveolin 1, caveolae protein, 22kDa	4.99	GeneCards inferred via : Publications (show sections)

Products for genes related to Bone Fracture disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	6	-	6	6
2	Novus Biologicals	5	4	6	-

Variations for Bone Fracture

Expression for genes affiliated with Bone Fracture

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ⁵⁴Reactome, ⁵⁹Thomson Reuters, ³⁰KEGG
See all sources

Pathways related to Bone Fracture according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	RhoGDI Pathway⁵² Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages⁵²	9.4	MYH2, MYH7
2	Clathrin derived vesicle budding⁵⁴ Show member pathways Lysosome Vesicle Biogenesis⁵⁴ Golgi Associated Vesicle Biogenesis⁵⁴ trans-Golgi Network Vesicle Budding⁵⁴ Membrane Trafficking⁵⁴ Translocation of GLUT4 to the Plasma Membrane⁵⁴	9.4	MYH2, MYH7
3	Immune response CCR3 signaling in eosinophils⁵⁹ Show member pathways Inhibitory action of Lipoxins on neutrophil migration⁵⁹	9.4	MYH2, MYH7
4	Tight junction³⁰	9.4	MYH7, MYH2
5	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.9	NUDT6, MYH7, MYH2
6	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.9	MYH2, MYH7, NUDT6
7	Cell adhesion Integrin mediated cell adhesion and migration⁵⁹ Show member pathways Cytoskeleton remodeling Fibronectin binding integrins in cell motility⁵⁹ Cytoskeleton remodeling Integrin outside in signaling⁵⁹ Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases⁵⁹ Cell adhesion Tight junctions⁵⁹ Development MAG dependent inhibition of neurite outgrowth⁵⁹	8.9	CAV1, MYH2, MYH7
8	Integrin Pathway⁵² Show member pathways Inhibition of Angiogenesis by TSP1⁵² Transendothelial Migration of Leukocytes⁵² FAK1 Signaling⁵² GnRH Signaling⁵² UPA-UPAR Pathway⁵²	8.9	MYH7, MYH2, CAV1

Compounds for genes affiliated with Bone Fracture

Sources:
⁶⁰Tocris Bioscience, ⁴⁴Novoseek, ²⁹IUPHAR, ³BitterDB, ⁵⁰PharmGKB, ²⁵HMDB, ¹²DrugBank
See all sources

Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show all 19)

id	Compound	Score	Top Affiliating Genes
1	(r)-(+)-blebbistatin⁶⁰	9.7	MYH7, MYH2
2	bts⁶⁰	9.7	MYH7, MYH2
3	(s)-(-)-blebbistatin⁶⁰	9.7	MYH7, MYH2
4	(+-)-blebbistatin⁶⁰	9.7	MYH7, MYH2
5	actomyosin⁴⁴	9.7	MYH2, MYH7
6	gp 130⁴⁴	9.5	CAV1, MYH7
7	procollagen⁴⁴	9.5	PCOLCE, BGLAP
8	bromodeoxyuridine⁴⁴	9.3	MYH7, NUDT6
9	caffeine⁴⁴ ²⁹ ³ ⁵⁰ ²⁵ ¹²	14.2	NUDT6, BGLAP
10	simvastatin⁴⁴ ⁵⁰ ⁶⁰ ²⁹ ²⁵ ¹²	14.0	BGLAP, CAV1
11	glutamate⁴⁴	8.9	NUDT6, MYH7, CAV1
12	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.8	BGLAP, NUDT6, CAV1
13	atp⁴⁴ ²⁹	9.8	CAV1, MYH7, NUDT6
14	vegf⁴⁴	8.8	CAV1, NUDT6, BGLAP
15	retinoic acid⁴⁴ ²⁵	9.3	CAV1, NUDT6, BGLAP
16	arginine⁴⁴	8.3	BGLAP, NUDT6, MYH7, CAV1
17	cysteine⁴⁴	8.3	BGLAP, NUDT6, MYH7, CAV1
18	serine⁴⁴	8.2	BGLAP, NUDT6, MYH7, CAV1
19	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	10.5	CAV1, PCOLCE, MYH2, MYH7, NUDT6, BGLAP

GO Terms for genes affiliated with Bone Fracture

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sarcomere	GO:030017	9.4	MYH2, MYH7
2	muscle myosin complex	GO:005859	9.3	MYH2, MYH7
3	myosin filament	GO:032982	9.1	MYH2, MYH7

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:006936	9.4	MYH2, MYH7
2	muscle filament sliding	GO:030049	9.3	MYH2, MYH7
3	response to activity	GO:014823	9.2	MYH2, BGLAP
4	response to estrogen	GO:043627	8.8	CAV1, BGLAP

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activator activity	GO:016504	9.5	CAV1, PCOLCE
2	microfilament motor activity	GO:000146	9.3	MYH2, MYH7
3	structural molecule activity	GO:005198	9.1	CAV1, BGLAP
4	calmodulin binding	GO:005516	9.1	MYH2, MYH7

Products for genes affiliated with Bone Fracture

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Bone Fracture

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: BNF002 MIFTS: 45	Bone Fracture malady Bone diseases category
6 genes, 18 tissues, 94 related diseases, clinical trials Download this MalaCard Expand all tables

Bone Fracture malady