MCID: BNF002
MIFTS: 50

Bone Fracture malady

Categories: Bone diseases

Aliases & Classifications for Bone Fracture

Aliases & Descriptions for Bone Fracture:

Name: Bone Fracture 38 52

Classifications:



Summaries for Bone Fracture

MalaCards based summary : Bone Fracture is related to spinal muscular atrophy type 1 with congenital bone fractures and antley-bixler syndrome without genital anomalies or disordered steroidogenesis. An important gene associated with Bone Fracture is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are ERK Signaling and Activation of cAMP-Dependent PKA. The drugs Teriparatide and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are cardiovascular system and liver/biliary system

Wikipedia : 71 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

Related Diseases for Bone Fracture

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 spinal muscular atrophy type 1 with congenital bone fractures 12.2
2 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.1
3 antley-bixler syndrome 10.9
4 gnathodiaphyseal dysplasia 10.8
5 hyper-ige recurrent infection syndrome 10.8
6 neuropathy, hereditary sensory and autonomic, type v 10.7
7 osteoporosis-pseudoglioma syndrome 10.7
8 tetanus 10.7
9 mucolipidosis iii alpha/beta 10.7
10 cerebroretinal microangiopathy with calcifications and cysts 10.7
11 multiple pterygium syndrome, lethal type 10.7
12 osteogenesis imperfecta, type i 10.7
13 cerebrospinal fluid leak 10.7
14 neuropathy, hereditary sensory and autonomic, type vii 10.7
15 bruck syndrome 10.7
16 osteofibrous dysplasia 10.7
17 vulvar vestibulitis syndrome 10.1 IL2 MB
18 lipodystrophy, familial partial, type 1 10.1 CRP TGFB1
19 paralytic poliomyelitis 10.1 IL2 TLR4
20 diffuse large b-cell lymphoma 10.1 CRP TGFB1
21 strawberry gallbladder 10.1 CRP IL2 TGFB1
22 liver inflammatory pseudotumor 10.1 IL2 TGFB1 TLR4
23 adult central nervous system choriocarcinoma 10.1 CAV1 TGFB1
24 lipodystrophy, familial partial, type 6 10.0 BGLAP LRP5 TGFB1
25 osteoporosis 10.0
26 bone angioendothelial sarcoma 10.0 CRP IL2 TGFB1
27 detrusor sphincter dyssynergia 10.0 IL2 TGFB1 TLR4
28 myiasis 10.0 CRP IL2 TGFB1 TLR4
29 acute chest syndrome 10.0 CRP TGFB1 TLR4
30 facial paralysis 9.9
31 rheumatoid arthritis 9.9 BGLAP CRP IL2 TGFB1 TLR4
32 bladder diffuse clear cell adenocarcinoma 9.8 FGF2 TGFB1
33 cerebritis 9.8
34 immunodeficiency due to defect in mapbp-interacting protein 9.7 CRP IL2 MB TGFB1 TLR4
35 obesity 9.7
36 brain injury 9.7
37 hepatitis 9.7
38 cervicitis 9.7
39 head injury 9.7
40 neuropathy 9.7
41 meningitis 9.7
42 hyperparathyroidism 9.7
43 breast cancer 9.7
44 tuberculosis 9.7
45 thyroiditis 9.6
46 hypogonadism 9.6
47 pharyngitis 9.6
48 muscular atrophy 9.6
49 osteoarthritis 9.6
50 prostate cancer 9.6

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to Bone Fracture

Symptoms & Phenotypes for Bone Fracture

MGI Mouse Phenotypes related to Bone Fracture:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CAV1 CRP FGF2 IL2 LRP5 MB
2 liver/biliary system MP:0005370 9.43 CAV1 IL2 LRP5 TGFB1 TGFBR3 TLR4
3 muscle MP:0005369 9.23 TLR4 CAV1 FGF2 MB MYH7 PCOLCE

Drugs & Therapeutics for Bone Fracture

Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 679)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52232-67-4 16133850
2
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1 84057-95-4 71273 175805
3
Ketorolac Approved Phase 4,Phase 3 74103-06-3, 66635-83-4 3826
4
Tramadol Approved, Investigational Phase 4,Phase 2 27203-92-5 33741
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-02-2 5743
6
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
7
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
8
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
9
Levobupivacaine Approved Phase 4,Phase 3,Phase 2 27262-47-1 92253
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
11
Calcium carbonate Approved Phase 4,Phase 3,Phase 2,Phase 1 471-34-1
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
14
Cefmetazole Approved Phase 4 56796-20-4 42008
15
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
16
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
17
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 76-42-6 5284603
18
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
19
Cilostazol Approved Phase 4 73963-72-1 2754
20
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
21
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
22
Etomidate Approved Phase 4 33125-97-2 36339 667484
23
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 5754 657311
24
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
25
Potassium Citrate Approved, Vet_approved Phase 4
26
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
27
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 1 112809-51-5 3902
28
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 437-38-7 3345
30
Methyclothiazide Approved Phase 4 135-07-9 4121
31
Indapamide Approved Phase 4 26807-65-8 3702
32
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
33
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
34
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
35
Desflurane Approved Phase 4 57041-67-5 42113
36
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
37
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206
38
Dalteparin Approved Phase 4,Phase 3,Phase 2 9041-08-1
39
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
40
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 50-24-8 5755
42
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
43
Ethanol Approved Phase 4 64-17-5 702
44
Alendronate Approved Phase 4,Phase 3,Phase 2,Phase 1 121268-17-5, 66376-36-1 2088
45
Cimetidine Approved Phase 4,Phase 2,Phase 3 51481-61-9 2756
46
Guaifenesin Approved, Vet_approved Phase 4,Early Phase 1 93-14-1 3516
47
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
48
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
49
Cefazolin Approved Phase 4,Phase 2 25953-19-9 656510 33255
50
Menthol Approved Phase 4,Phase 2,Phase 3,Early Phase 1 2216-51-5 16666

Interventional clinical trials:

(show top 50) (show all 2582)
id Name Status NCT ID Phase
1 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
2 The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures Unknown status NCT01173081 Phase 4
3 Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
4 Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol Unknown status NCT01052974 Phase 4
5 NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures Unknown status NCT00969839 Phase 4
6 RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child Unknown status NCT00560443 Phase 4
7 Parathyroid Hormone for the Treatment of Humerus Fractures Unknown status NCT01687374 Phase 4
8 Single Dose of Dexamethasone in Femur Fractures Unknown status NCT01550146 Phase 4
9 The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery Unknown status NCT00162617 Phase 4
10 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
11 Hematoma Block for Reduction of Distal Radius Fractures Unknown status NCT02129270 Phase 4
12 Fast Track Admittance of Hip Fracture Patients Unknown status NCT00345488 Phase 4
13 Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture Unknown status NCT01509859 Phase 4
14 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
15 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4
16 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4
17 Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Unknown status NCT02104908 Phase 4
18 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
19 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4
20 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
21 Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw Unknown status NCT01219088 Phase 4
22 Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis Unknown status NCT00941213 Phase 4
23 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4
24 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4
25 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
26 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
27 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4
28 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4
29 Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? Unknown status NCT02090244 Phase 4
30 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
31 The Effects of Potassium Citrate on Bone Metabolism Unknown status NCT00357331 Phase 4
32 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4
33 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4
34 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
35 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4
36 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4
37 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4
38 A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Unknown status NCT00208442 Phase 4
39 The Hypertension in the Very Elderly Trial (HYVET) Unknown status NCT00122811 Phase 4
40 Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors Unknown status NCT00111241 Phase 4
41 Study Evaluating InductOs in Diaphyseal Tibia Fractures Completed NCT00161616 Phase 4
42 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4
43 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
44 Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures Completed NCT00552331 Phase 4
45 Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate Completed NCT01437150 Phase 4
46 Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants Completed NCT01431560 Phase 4
47 OSTPRE-Fracture Prevention Study Completed NCT00592917 Phase 4
48 Waterproof Casting for Pediatric Distal Radius Fractures Completed NCT02095106 Phase 4
49 Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture Completed NCT00774618 Phase 4
50 Non Randomized Humerusshaft Fracture Completed NCT00205972 Phase 4

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

Anatomical Context for Bone Fracture

MalaCards organs/tissues related to Bone Fracture:

39
Bone, Brain, Spinal Cord, Liver, Breast, Bone Marrow, Prostate
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Bone Fracture

Articles related to Bone Fracture:

(show top 50) (show all 648)
id Title Authors Year
1
Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study. ( 27836732 )
2017
2
Spinal Reorganization after Bone Fracture in Mice. ( 28062308 )
2017
3
An Algorithmic Approach Using Ultrasonography in the Diagnosis of Pediatric Nasal Bone Fracture. ( 27906845 )
2017
4
Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade. ( 27664567 )
2016
5
Postoperative Satisfaction in Nasal Bone Fracture Patients Who Had Rhinoplasty. ( 27748725 )
2016
6
Computational simulation of bone fracture healing under inverse dynamisation. ( 27220876 )
2016
7
Biological Risk Factors for Nonunion of Bone Fracture. ( 27490008 )
2016
8
Novel effects of sarcopenic osteoarthritis on metabolic syndrome, insulin resistance, osteoporosis, and bone fracture: the national survey. ( 27177746 )
2016
9
Hyoid Bone Fracture: Associated With Head and Neck Trauma-A Rare Case Report. ( 27408446 )
2016
10
The impact velocity and bone fracture pattern: Forensic perspective. ( 27220089 )
2016
11
Sport Practice And Occurrence Of Bone Fracture In Adolescents During 9-months Of Follow-up: 2090 Board #242 June 2, 2: 00 PM - 3: 30 PM. ( 27360915 )
2016
12
Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation. ( 27955656 )
2016
13
Recurrent Fat Embolic Strokes in a Patient With Duchenne Muscular Dystrophy With Long Bone Fractures and a Patent Foramen Ovale. ( 27595520 )
2016
14
Implantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study. ( 27538760 )
2016
15
Contralateral Cochlear Labyrinthine Concussion without Temporal Bone Fracture: Unusual Posttraumatic Consequence. ( 27738540 )
2016
16
Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. ( 26924529 )
2016
17
Should orthopedic surgeons consider the effects of gabapentin administration on bone healing while treating a long bone fracture: experimental study in a rat model. ( 27801642 )
2016
18
Association of Respiratory Tuberculosis with Incident Bone Fracture: Bridging the Tuberculosis Airway Infection and the Osteoporotic Bone. ( 28005963 )
2016
19
Ulnar nerve paralysis after forearm bone fracture. ( 27517030 )
2016
20
Bone fracture nonunion rate decreases with increasing age: Bias in the prediction model. ( 27993595 )
2016
21
The crucial role of neutrophil granulocytes in bone fracture healing. ( 27452963 )
2016
22
Limits of internal fixation in long-bone fracture. ( 28082050 )
2016
23
Biomechanical Studies on Patterns of Cranial Bone Fracture Using the Immature Porcine Model. ( 27537363 )
2016
24
Long-term response of femoral density to hip implant and bone fracture plate: Computational study using a mechano-biochemical model. ( 26751582 )
2016
25
Computer assisted preoperative planning of bone fracture reduction: Simulation techniques and new trends. ( 26849422 )
2016
26
Central tarsal bone fracture in a cat. ( 26846689 )
2016
27
Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovariectomy-induced osteoporotic rats. ( 27155884 )
2016
28
Reevaluating the Utility of Maxillary Sinus Opacification as a Screening Tool for Facial Bone Fracture a Decade After Its Original Analysis. ( 27014521 )
2016
29
Audiologic Patterns of Otic Capsule Preserving Temporal Bone Fracture: Effects of the Affected Subsites. ( 27337953 )
2016
30
Traumatic Cochlear Nerve Avulsion Following Otic-Capsule Sparing Temporal Bone Fracture. ( 27454988 )
2016
31
A comparative study on the in vivo degradation of poly(L-lactide) based composite implants for bone fracture fixation. ( 26857951 )
2016
32
Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. ( 27089041 )
2016
33
Bone: Fracture risk after bariatric surgery. ( 27516344 )
2016
34
Bone fracture healing is delayed in splenectomic rats. ( 27956350 )
2016
35
Abducens Nerve Avulsion and Facial Nerve Palsy After Temporal Bone Fracture: A Rare Concomitance of Injuries. ( 26723286 )
2016
36
Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )
2016
37
Ten-year estimated risk of bone fracture in women with differentiated thyroid cancer under TSH-suppressive levothyroxine therapy. ( 27387240 )
2016
38
Pioglitazone and Risk for Bone Fracture: Safety Data from a Randomized Clinical Trial. ( 27935736 )
2016
39
Modelling of bone fracture and strength at different length scales: a review. ( 26855749 )
2016
40
Larynx Trauma and Hyoid Bone Fracture after Bite Injury in Dog: Case Report. ( 27579303 )
2016
41
Cortical bone fracture analysis using XFEM - case study. ( 27287280 )
2016
42
Investigation of the mechanical properties and failure modes of hybrid natural fiber composites for potential bone fracture fixation plates. ( 27618754 )
2016
43
Elevated D-dimer and fibrinogen levels in serum of preoperative bone fracture patients. ( 27026858 )
2016
44
Post-traumatic transient cortical blindness in a child with occipital bone fracture. ( 27707613 )
2016
45
Temporal bone fracture: Evaluation in the era of modern computed tomography. ( 27387791 )
2016
46
Impact and risk factors of post-stroke bone fracture. ( 26929915 )
2016
47
Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis. ( 27075747 )
2016
48
Correction: Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. ( 27684704 )
2016
49
Epihyoid bone fracture associated with tongue deviation in an adult dog. ( 27587884 )
2016
50
Surface Reconstruction from Parallel Curves with Application to Parietal Bone Fracture Reconstruction. ( 26967643 )
2016

Variations for Bone Fracture

Expression for Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for Bone Fracture

Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 FGF2 IL2 IL3 LRP5 MYH2 MYH7
2
Show member pathways
13.41 CRP FGF2 IL2 IL3 NUDT6 TGFB1
3
Show member pathways
13.18 FGF2 IL2 IL3 NUDT6 TGFB1 TGFBR3
4
Show member pathways
13.11 CAV1 FGF2 IL2 IL3 NUDT6 TGFB1
5
Show member pathways
12.82 FGF2 IL2 IL3 NUDT6 TGFB1 TGFBR3
6
Show member pathways
12.79 FGF2 IL2 IL3 NUDT6 TGFB1 TGFBR3
7
Show member pathways
12.65 CAV1 IL2 IL3 MYH7 TGFB1
8
Show member pathways
12.62 FGF2 IL2 IL3 MYH2 MYH7 NUDT6
9 12.43 FGF2 IL2 IL3 TLR4
10 12.09 CAV1 FGF2 TGFB1 TLR4
11 11.93 FGF2 IL3 TGFB1
12 11.92 CAV1 TGFB1 TGFBR3
13 11.85 IL2 TGFB1 TLR4
14
Show member pathways
11.78 IL2 TGFB1 TLR4
15
Show member pathways
11.75 TGFB1 TGFBR3 TLR4
16
Show member pathways
11.72 FGF2 IL2 IL3 NUDT6 TGFB1 TLR4
17 11.71 BGLAP FGF2 TGFB1
18 11.68 IL2 TGFB1 TLR4
19 11.64 FGF2 TGFB1 TGFBR3
20 11.54 LRP5 TGFB1 TLR4
21 11.34 FGF2 IL2 IL3 NUDT6 TGFB1
22 11.29 CAV1 TGFB1 TGFBR3
23 11.23 FGF2 TGFB1 TGFBR3
24 11.18 FGF2 IL3 TGFB1
25 10.93 TGFB1 TGFBR3
26 10.81 IL2 IL3 TGFB1

GO Terms for Bone Fracture

Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP CRP CRTAC1 FGF2 IL2 IL3
2 extracellular space GO:0005615 9.23 BGLAP CRP FGF2 IL2 IL3 PCOLCE
3 myosin filament GO:0032982 9.16 MYH2 MYH7

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 CAV1 CRP TGFB1 TLR4
2 positive regulation of cell proliferation GO:0008284 9.72 FGF2 IL2 IL3 LRP5 TGFB1
3 beta-catenin destruction complex disassembly GO:1904886 9.6 CAV1 LRP5
4 positive regulation of cardiac muscle cell proliferation GO:0060045 9.59 FGF2 TGFBR3
5 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 FGF2 TGFB1
6 response to vitamin D GO:0033280 9.58 BGLAP TGFB1
7 regulation of the force of heart contraction GO:0002026 9.57 CAV1 MYH7
8 osteoblast development GO:0002076 9.55 BGLAP LRP5
9 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.54 IL2 IL3
10 hyaluronan catabolic process GO:0030214 9.52 FGF2 TGFB1
11 negative regulation of blood vessel endothelial cell migration GO:0043537 9.51 FGF2 TGFB1
12 pathway-restricted SMAD protein phosphorylation GO:0060389 9.49 TGFB1 TGFBR3
13 positive regulation of interleukin-17 production GO:0032740 9.48 IL2 TGFB1
14 positive regulation of peptidase activity GO:0010952 9.46 CAV1 PCOLCE
15 response to hypoxia GO:0001666 9.46 CAV1 MB TGFB1 TGFBR3
16 negative regulation of interleukin-17 production GO:0032700 9.43 TGFB1 TLR4
17 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.43 CAV1 TGFB1 TGFBR3
18 positive regulation of regulatory T cell differentiation GO:0045591 9.4 IL2 TGFB1
19 positive regulation of superoxide anion generation GO:0032930 9.37 CRP TGFB1
20 MAPK cascade GO:0000165 9.35 CAV1 FGF2 IL2 IL3 TGFB1
21 ventricular cardiac muscle tissue morphogenesis GO:0055010 8.8 MYH7 TGFB1 TGFBR3

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 FGF2 IL2 IL3
2 cytokine activity GO:0005125 9.46 FGF2 IL2 IL3 TGFB1
3 microfilament motor activity GO:0000146 9.37 MYH2 MYH7
4 peptidase activator activity GO:0016504 9.26 CAV1 PCOLCE
5 growth factor activity GO:0008083 9.02 FGF2 IL2 IL3 NUDT6 TGFB1
6 type II transforming growth factor beta receptor binding GO:0005114 8.96 TGFB1 TGFBR3

Sources for Bone Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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