Bone Fracture disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNF002 MIFTS: 56	Bone Fracture Categories: Bone diseases
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Aliases & Classifications for Bone Fracture

MalaCards integrated aliases for Bone Fracture:

Name: Bone Fracture ³⁷ ⁵¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

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Summaries for Bone Fracture

MalaCards based summary : Bone Fracture is related to osteofibrous dysplasia and osteoporosis. An important gene associated with Bone Fracture is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are GPCR Pathway and ERK Signaling. The drugs Teriparatide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are cardiovascular system and cellular

Wikipedia : ⁷² A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

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Related Diseases for Bone Fracture

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)

#	Related Disease	Score	Top Affiliating Genes
1	osteofibrous dysplasia	31.7	BGLAP BMP2 TGFB1
2	osteoporosis	30.0	BGLAP BMP2 CRP LRP5 TGFB1
3	spinal muscular atrophy, type i, with congenital bone fractures	12.4
4	spinal muscular atrophy with congenital bone fractures 2	12.3
5	prenatal-onset spinal muscular atrophy with congenital bone fractures	12.0
6	antley-bixler syndrome without genital anomalies or disordered steroidogenesis	11.2
7	antley-bixler syndrome	11.0
8	polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	11.0
9	hyper-ige recurrent infection syndrome, autosomal dominant	10.9
10	gnathodiaphyseal dysplasia	10.9
11	osteogenesis imperfecta, type i	10.8
12	mucolipidosis iii alpha/beta	10.8
13	multiple pterygium syndrome, lethal type	10.8
14	osteoporosis-pseudoglioma syndrome	10.8
15	pyle disease	10.8
16	spinal muscular atrophy, x-linked 2	10.8
17	neuropathy, hereditary sensory and autonomic, type v	10.8
18	cerebroretinal microangiopathy with calcifications and cysts 1	10.8
19	neuropathy, hereditary sensory and autonomic, type vii	10.8
20	bruck syndrome	10.8
21	rickets	10.8
22	tetanus	10.8
23	osteitis fibrosa	10.8
24	cerebrospinal fluid leak	10.8
25	aortic valve disease 1	10.3	BMP2 CRP TGFB1
26	glanders	10.3	LRP5 TLR4
27	intestinal disease	10.3	CRP STAT3 TLR4
28	eosinophilic variant of chromophobe renal cell carcinoma	10.3	CAV1 TGFB1
29	diabetic foot ulcers	10.3	CRP TGFB1
30	camurati-engelmann disease	10.3	BGLAP LRP5 TGFB1
31	variola major	10.3	IL2 TLR4
32	bone resorption disease	10.3	BGLAP BMP2 LRP5
33	aortic valve disease 2	10.2	BMP2 CRP MYH7
34	bone remodeling disease	10.2	BGLAP BMP2 LRP5
35	periodontitis	10.2	BGLAP CRP TLR4
36	virus associated hemophagocytic syndrome	10.2	IL2 MB
37	tympanosclerosis	10.2	BMP2 TLR4
38	brucellosis	10.2	CRP IL2 TLR4
39	bone mineral density quantitative trait locus 8	10.1
40	bone mineral density quantitative trait locus 15	10.1
41	primary bacterial infectious disease	10.1	CRP IL2 TLR4
42	heritable pulmonary arterial hypertension	10.1	CAV1 TGFB1
43	chagas disease	10.0	IL2 TGFB1 TLR4
44	facial paralysis	10.0
45	episodic pain syndrome, familial, 1	10.0
46	aging	10.0
47	visceral leishmaniasis	10.0	CRP IL2 TLR4
48	leukocyte disease	9.9	CRP IL2 IL3
49	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	9.9
50	cerebritis	9.9

Graphical network of the top 20 diseases related to Bone Fracture:

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Symptoms & Phenotypes for Bone Fracture

MGI Mouse Phenotypes related to Bone Fracture:

⁴³

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.22	FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
2	cellular	MP:0005384	10.11	FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
3	hematopoietic system	MP:0005397	10.06	FGF2 STAT3 IL2 TGFB1 LRP5 BMP2
4	liver/biliary system	MP:0005370	9.86	STAT3 IL2 TGFB1 LRP5 LTBP1 CAV1
5	muscle	MP:0005369	9.85	FGF2 STAT3 TGFB1 LTBP1 CAV1 MB
6	neoplasm	MP:0002006	9.43	FGF2 STAT3 IL2 TGFB1 CAV1 TLR4
7	skeleton	MP:0005390	9.32	FGF2 STAT3 TGFB1 LRP5 BMP2 LTBP1

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Drugs & Therapeutics for Bone Fracture

Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 686)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Teriparatide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

52232-67-4

16133850

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

50-02-2

5743

Lidocaine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

137-58-6

3676

Bupivacaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

38396-39-3, 2180-92-9

2474

Iron

Approved

Phase 4,Phase 3,Phase 2

7439-89-6

23925

Tranexamic Acid

Approved

Phase 4,Phase 3,Phase 2

1197-18-8

5526

Levobupivacaine

Approved, Investigational

Phase 4,Phase 3,Phase 2

27262-47-1

92253

Propofol

Approved, Investigational, Vet_approved

Phase 4,Phase 3

2078-54-8

4943

Ropivacaine

Approved

Phase 4,Phase 3,Phase 2,Phase 1

84057-95-4

175805 71273

Calcium Carbonate

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

471-34-1

Dexmedetomidine

Approved, Vet_approved

Phase 4,Phase 3,Phase 1

76631-46-4, 113775-47-6

5311068 56032 68602

Thrombin

Approved, Investigational

Phase 4

Morphine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

57-27-2

5288826

Cefmetazole

Approved, Investigational

Phase 4

56796-20-4

42008

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Epinephrine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

51-43-4

5816

Ketorolac

Approved

Phase 4,Phase 3,Phase 2

74103-06-3, 66635-83-4

3826

Oxycodone

Approved, Illicit, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1

76-42-6

5284603

Racepinephrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1

329-65-7

Rocuronium

Approved

Phase 4,Phase 3

119302-91-9, 143558-00-3

441290

Aspirin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

50-78-2

2244

Cilostazol

Approved, Investigational

Phase 4

73963-72-1

2754

Clopidogrel

Approved

Phase 4

120202-66-6, 113665-84-2

60606

Linagliptin

Approved

Phase 4

668270-12-0

10096344

Pioglitazone

Approved, Investigational

Phase 4,Phase 2

111025-46-8

4829

Letrozole

Approved, Investigational

Phase 4,Phase 3,Phase 1

112809-51-5

3902

Zoledronic acid

Approved

Phase 4,Phase 2,Phase 3,Phase 1

118072-93-8

68740

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Isosorbide Dinitrate

Approved, Investigational

Phase 4

87-33-2

6883

Nitric Oxide

Approved

Phase 4,Phase 1

10102-43-9

145068

Etomidate

Approved

Phase 4

33125-97-2

667484 36339

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

657311 5754

Midazolam

Approved, Illicit

Phase 4,Phase 3,Phase 2

59467-70-8

4192

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2

1994-09-7, 94-09-7

2337

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

437-38-7

3345

Anastrozole

Approved, Investigational

Phase 4,Phase 3

120511-73-1

2187

Indapamide

Approved

Phase 4

26807-65-8

3702

Perindopril

Approved

Phase 4

107133-36-8, 82834-16-0

107807

Tramadol

Approved, Investigational

Phase 4,Phase 2

27203-92-5

33741

Sevoflurane

Approved, Vet_approved

Phase 4,Phase 2

28523-86-6

5206

Desflurane

Approved

Phase 4

57041-67-5

42113

Acetaminophen

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

103-90-2

1983

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Early Phase 1

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Early Phase 1

50-24-8

5755

Dalteparin

Approved

Phase 4,Phase 3,Phase 2

9005-49-6

Heparin

Approved, Investigational

Phase 4,Phase 3,Phase 2

9005-49-6

46507594 772

Ibuprofen

Approved

Phase 4,Phase 3,Phase 2,Early Phase 1

15687-27-1

3672

Acetylcholine

Approved

Phase 4,Phase 1

51-84-3

187

Ethanol

Approved

Phase 4

64-17-5

702

Alendronate

Approved

Phase 4,Phase 3,Phase 2,Phase 1

121268-17-5, 66376-36-1

2088

Interventional clinical trials:

(show top 50) (show all 2893)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail	Unknown status	NCT01437176	Phase 4
2	The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures	Unknown status	NCT01173081	Phase 4	Teriparatide;Placebo
3	Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture	Unknown status	NCT00829725	Phase 4
4	NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures	Unknown status	NCT00969839	Phase 4
5	Parathyroid Hormone for the Treatment of Humerus Fractures	Unknown status	NCT01687374	Phase 4	1-84 parathyroid hormone;Placebo
6	Single Dose of Dexamethasone in Femur Fractures	Unknown status	NCT01550146	Phase 4	Dexamethasone acetate;Placebo
7	Hematoma Block for Reduction of Distal Radius Fractures	Unknown status	NCT02129270	Phase 4	Lidocaine HCl 2% .;Lidocaine HCl 1%
8	Outcome Comparison Between PFNA and InterTAN	Unknown status	NCT01797237	Phase 4
9	The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery	Unknown status	NCT00162617	Phase 4	Red blood cell transfusion
10	Fast Track Admittance of Hip Fracture Patients	Unknown status	NCT00345488	Phase 4
11	Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture	Unknown status	NCT01509859	Phase 4
12	Dose Finding Study for Continuous Spinal Anaesthesia	Unknown status	NCT01680120	Phase 4
13	Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia	Unknown status	NCT01084122	Phase 4	Iron sucrose
14	Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures	Unknown status	NCT02580227	Phase 4	Tranexamic Acid
15	A Dose Finding Study for Pain Relief of a Broken Hip	Unknown status	NCT00926666	Phase 4	Levobupivacaine
16	Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly	Unknown status	NCT02104908	Phase 4
17	Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures	Unknown status	NCT01482858	Phase 4
18	Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty	Unknown status	NCT01934049	Phase 4	Total Intravenous Anesthesia and Peripheral nerve blocks
19	Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel)	Unknown status	NCT01230931	Phase 4
20	Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw	Unknown status	NCT01219088	Phase 4	Bupivacaine, morphine
21	Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis	Unknown status	NCT00941213	Phase 4
22	The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement	Unknown status	NCT01112436	Phase 4	periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
23	Deep Neuromuscular Block on Cytokines Release and Postoperative Delirium	Unknown status	NCT02507609	Phase 4
24	Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease	Unknown status	NCT01653600	Phase 4
25	Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo	Unknown status	NCT01945788	Phase 4	Teriparatide (rDNA origin)
26	A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers	Unknown status	NCT02429232	Phase 4	Pioglitazone;Linagliptin
27	Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace)	Unknown status	NCT01908556	Phase 4	Letrozole
28	The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion	Unknown status	NCT01310465	Phase 4	zoledronic acid;sodium chloride
29	Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD)	Unknown status	NCT01822106	Phase 4
30	Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus	Unknown status	NCT02011620	Phase 4
31	Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children	Unknown status	NCT02013986	Phase 4	etomidate;midazolam;propofol
32	Role of Stress Reduction Protocol on Outcome of Periodontal Therapy	Unknown status	NCT02487862	Phase 4
33	Bone Turnover in Type 2 Diabetes Patients	Unknown status	NCT00732121	Phase 4	Sitagliptin;Placebo
34	Manually Versus Digitally Fabricated Removable Partial Dentures	Unknown status	NCT01191073	Phase 4
35	Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics	Unknown status	NCT02389179	Phase 4	Vitamin D3
36	Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC	Unknown status	NCT01795794	Phase 4	omeprazole
37	Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients	Unknown status	NCT00912938	Phase 4	zoledronic acid
38	Intranasal Fentanyl for Pain Management	Unknown status	NCT00882960	Phase 4	intravenous fentanyl;intra-nasal fentanyl
39	Comparison of Efficacy and Safety of Microfracture and Modified Microfracture	Unknown status	NCT02539030	Phase 4
40	Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors	Unknown status	NCT00111241	Phase 4	aromatase inhibitors (letrozole, anastrozole)
41	The Hypertension in the Very Elderly Trial (HYVET)	Unknown status	NCT00122811	Phase 4	Indapamide SR 1.5mg; Perindopril 2-4mg
42	Study Evaluating InductOs in Diaphyseal Tibia Fractures	Completed	NCT00161616	Phase 4	InductOs
43	Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants	Completed	NCT01431560	Phase 4
44	Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate	Completed	NCT01437150	Phase 4
45	Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures	Completed	NCT00552331	Phase 4
46	Allomatrix Injectable Putty in Distal Radius Fractures	Completed	NCT00274378	Phase 4
47	Efficacy of DBM on Fractures of the Shinbone (Tibia)	Completed	NCT00299052	Phase 4
48	RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child	Completed	NCT00560443	Phase 4	ketorolac;tramadol
49	Effect of Anesthesia in Fracture Healing	Completed	NCT02621255	Phase 4	Sevoflurane;Bupivacaine
50	Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture	Completed	NCT00824564	Phase 4	Tranexamic Acid plus standard of care

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Bone Fracture cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Bone Fracture:

	ALLOB
	Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
	Map3
	Ovation
	PREOB
	Stromal vascular fraction cells for osteoporotic bone fractures

Embryonic/Adult Cultured Cells Related to Bone Fracture:

	Bone marrow-derived mesenchymal stem cells PMIDs: 23180104
	Bone marrow-derived adherent progenitor cells (MultiStem)
	Stromal vascular fraction cells PMIDs: 21605897 16488036

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Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

MalaCards organs/tissues related to Bone Fracture:

³⁸

Bone, Breast, Prostate, Bone Marrow, Kidney, Spinal Cord, Testes

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:

#	Tissue Anatomical CompartmentCell	Relevance
1	Adipose Subcutaneous White Adipose Mesenchymal Stem Cells	Potential therapeutic candidate
2	Adipose Subcutaneous White Adipose Stromal Cells	Potential therapeutic candidate

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Publications for Bone Fracture

Articles related to Bone Fracture:

(show top 50) (show all 694)

#	Title	Authors	Year
1	Mineralized collagen fibril network spatial arrangement influences cortical bone fracture behavior. ( 29137726 )	Wang Y....Ural A.	2018
2	Hypophosphatemic Osteomalacia with Multiple Bone Fractures: ADV-Induced Fanconi's Syndrome. ( 29399572 )	Kim J.H....Lee K.A.	2018
3	Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )	Gray N....To T.	2018
4	Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression. ( 29383945 )	Vukicevic A.M....Filipovic N.D.	2018
5	Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. ( 29146294 )	Prystaz K....Ignatius A.	2018
6	The Impact of Type 2 Diabetes on Bone Fracture Healing. ( 29416527 )	Marin C....Vandamme K.	2018
7	Estrogen receptor I+- (ERI+), but not ERI^-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration. ( 29367057 )	Haffner-Luntzer M....Ignatius A.	2018
8	The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. ( 29356996 )	Daish C....Pirogova E.	2018
9	Pain Intensity and Risk of Bone Fracture in Children With Minor Extremity Injuries. ( 29369266 )	Zanchi C....Barbi E.	2018
10	Regenerate bone fracture rate following femoral lengthening in paediatric patients. ( 28828065 )	Burke N.G....Moore D.	2017
11	Convex bone deformity after closed reduction of nasal bone fracture. ( 28918998 )	Nishioka H....Yuzuriha S.	2017
12	Epidemiology of Bone Fracture in Female Trauma Patients Based on Risks of Osteoporosis Assessed using the Osteoporosis Self-Assessment Tool for Asians Score. ( 29137199 )	Rau C.S....Hsieh C.H.	2017
13	Occurrence of Clinical Bone Fracture Following a Prolonged Stay in Intensive Care Unit: A Retrospective Controlled Study. ( 28695239 )	Rousseau A.F....BruyA"re O.	2017
14	Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes. ( 28924381 )	Wang P....Jin H.	2017
15	Improving the human-robot interface for telemanipulated robotic long bone fracture reduction: Joystick device vs. haptic manipulator. ( 28948678 )	Suero E.M....Stuebig T.	2017
16	Analysis of Facial Symmetry After Zygomatic Bone Fracture Management. ( 29121488 )	Khaqani M.S....Khojastepour L.	2017
17	A Rare Case of Infantile Myofibromatosis Presenting to the Emergency Department as Undiagnosed Long Bone Fractures. ( 29095782 )	McGuire M.A....Hong N.	2017
18	Delayed Expression of Circulating TGF-I^1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing. ( 28331138 )	Hara Y....Yokota H.	2017
19	Factors related to infection after fixation in the process of late healed bone fracture. ( 28810567 )	Zhang X....An H.	2017
20	Objective Outcomes of Closed Reduction According to the Type of Nasal Bone Fracture. ( 28913300 )	Kang C.M....Han D.G.	2017
21	Reliability of temporal bone high-resolution CT in patients with facial paralysis in temporal bone fracture. ( 29258690 )	Chen Y....Li Y.	2017
22	The interplay of transcriptional and post-transcriptional regulation of migration of mesenchymal stem cells during early stages of bone fracture healing. ( 29271984 )	Dong C.H....Zhen P.	2017
23	STAT3 promotes bone fracture healing by enhancing the FOXP3 expression and the suppressive function of regulatory T cells. ( 28493494 )	Sun G....Qian H.	2017
24	Impairment of cold injury-induced muscle regeneration in mice receiving a combination of bone fracture and alendronate treatment. ( 28715470 )	Kawada S....Hashimoto N.	2017
25	Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study. ( 27836732 )	Zura R....Steen R.G.	2017
26	The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing. ( 28677081 )	Zhang L....Ebeling P.	2017
27	Association between metabolic syndrome and bone fracture risk: A community-based study using a fracture risk assessment tool. ( 29390327 )	Yu C.Y....Chien R.N.	2017
28	Pathological bone fractures in a patient with parathyroid carcinoma - A Case Report. ( 29256556 )	Shahid A....Iftikhar F.	2017
29	Spinal Reorganization after Bone Fracture in Mice. ( 28062308 )	Hirsch S....Birklein F.	2017
30	The Algorithm-Oriented Management of Nasal Bone Fracture according to Stranc's Classification System. ( 28913315 )	Park K.S....Yang W.S.	2017
31	Actual reason for bone fractures in the case of a patient followed-up with the osteogenesis imperfecta: Gaucher's Disease. ( 29354164 )	Demirci U....Aydogdu I.	2017
32	Correlation between Operation Result and Patient Satisfaction of Nasal Bone Fracture. ( 28913299 )	Kang C.M....Han D.G.	2017
33	Olfactory Dysfunction in Nasal Bone Fracture. ( 28913314 )	Kim S.W....Kim J.Y.	2017
34	The effects of dipeptidyl peptidase-4 inhibitors on bone fracture among patients with type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials. ( 29206832 )	Yang J....Zhan S.	2017
35	Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity. ( 28777474 )	Kroner J....Ignatius A.	2017
36	Non-union bone fracture: a quicker fix. ( 29069072 )	Holmes D.	2017
37	Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. ( 28885321 )	Xue A.L....Zhao P.	2017
38	Using temporal bone computed tomography to predict sensorineural hearing loss in otic capsule-sparing temporal bone fracture. ( 29096926 )	Mun S.K....Chang M.Y.	2017
39	Study of fall risk-increasing drugs in elderly patients before and after a bone fracture. ( 28916557 )	Beunza-Sola M....GarcA-a-Mata S.	2017
40	Preliminary results of vibro-acoustography evaluation of bone surface and bone fracture. ( 29184767 )	Nogueira-Barbosa M.H....Carneiro A.A.O.	2017
41	An Algorithmic Approach Using Ultrasonography in the Diagnosis of Pediatric Nasal Bone Fracture. ( 27906845 )	Tamada I....Kamogawa R.	2017
42	The effect of light-emitting diode (590/830A nm)-based low-level laser therapy on posttraumatic edema of facial bone fracture patients. ( 28986000 )	Baek W.Y....Kim Y.S.	2017
43	In vivo study of microarc oxidation coated biodegradable magnesium plate to heal bone fracture defect of 3mm width. ( 28688364 )	Wu Y.F....Zhou Y.	2017
44	A novel etiology for pneumolabyrinth after temporal bone fracture without otic capsule involvement. ( 29121383 )	Muelleman T.J....Staecker H.	2017
45	A review of computational models of bone fracture healing. ( 28785849 )	Wang M....Wang X.	2017
46	Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. ( 29070810 )	Kovtun A....Ignatius A.	2017
47	Customized titanium mesh based on the 3D printed model vs. manual intraoperative bending of titanium mesh for reconstructing of orbital bone fracture: a randomized clinical trial. ( 28828975 )	Raisian S....Azdoo S.	2017
48	Computer assisted preoperative planning of bone fracture reduction: Simulation techniques and new trends. ( 26849422 )	JimAcnez-Delgado J.J....JimAcnez-PAcrez J.R.	2016
49	Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )	Ghiasi S....Banaei M.	2016
50	Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovariectomy-induced osteoporotic rats. ( 27155884 )	Chow S.K....Cheung W.H.	2016

Sources

Genes for Bone Fracture

Genes related to Bone Fracture (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication
1	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	18.46	GeneCards inferred via : Publications (show sections)
2	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	17.83	GeneCards inferred via : Publications (show sections)
3	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
4	BMP2	Bone Morphogenetic Protein 2	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
5	CRP	C-Reactive Protein	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
6	TLR4	Toll Like Receptor 4	Protein Coding	17.48	GeneCards inferred via : Publications (show sections)
7	MYH2	Myosin Heavy Chain 2	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
8	NUDT6	Nudix Hydrolase 6	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
9	MB	Myoglobin	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
10	MYH7	Myosin Heavy Chain 7	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
11	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
12	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
13	LRP5	LDL Receptor Related Protein 5	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
14	CAV1	Caveolin 1	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
15	IL2	Interleukin 2	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
16	IL3	Interleukin 3	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
17	PCOLCE	Procollagen C-Endopeptidase Enhancer	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
18	FGF2	Fibroblast Growth Factor 2	Protein Coding	17.14	GeneCards inferred via : Publications (show sections)
19	CRTAC1	Cartilage Acidic Protein 1	Protein Coding	7.14	GeneCards inferred via : Publications (show sections)

Sources

Variations for Bone Fracture

Sources

Expression for Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Sources

Pathways for Bone Fracture

Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 38)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶⁰ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁰ Estrogen Pathway ⁶⁰ NFAT in Immune Response ⁶⁰ P2Y Receptor Signaling ⁶⁰ Pancreatic Adenocarcinoma ⁶⁰ Paxillin Interactions ⁶⁰ Ras Pathway ⁶⁰	13.67	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
2	ERK Signaling ⁶⁰ Show member pathways ILK Signaling ⁶⁰ MAPK Signaling ⁶⁰ Molecular Mechanisms of Cancer ⁶⁰ Rho Family GTPases ⁶⁰	13.5	BMP2 FGF2 IL2 IL3 LRP5 LTBP1
3	Activation of cAMP-Dependent PKA ⁶⁰ Show member pathways Activation of PKA through GPCR ⁶⁰ cAMP Pathway ⁶⁰ PKA Signaling ⁶⁰	13.49	BMP2 CRP FGF2 IL2 IL3 LTBP1
4	TGF-Beta Pathway ⁶⁰ Show member pathways JAK-STAT Pathway ⁶⁰ JNK Pathway ⁶⁰ MAPK Family Pathway ⁶⁰ Regulation of eIF4 and p70S6K ⁶⁰ SOCS Pathway ⁶⁰	13.47	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
5	Akt Signaling ⁶⁰ Show member pathways p38 Signaling ⁶⁰ Tec Kinases Signaling ⁶⁰	13.26	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
6	CREB Pathway ⁶⁰ Show member pathways Activation of PKC through GPCR ⁶⁰ Intracellular Calcium Signaling ⁶⁰ IP3 Pathway ⁶⁰	13.25	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
7	Nanog in Mammalian ESC Pluripotency ⁶⁰ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁰ eNOS Signaling ⁶⁰ GSK3 Signaling ⁶⁰	13.17	BMP2 CAV1 FGF2 IL2 IL3 LTBP1
8	PAK Pathway ⁶⁰ Show member pathways Antioxidant Action of Vitamin-C ⁶⁰ Epithelial Adherens Junctions ⁶⁰	12.92	BMP2 FGF2 IL2 IL3 LTBP1 MYH2
9	Phospholipase-C Pathway ⁶⁰ Show member pathways PTEN Pathway ⁶⁰	12.81	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
10	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶⁰ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶⁰ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.79	CAV1 IL2 IL3 MYH7 TGFB1
11	Degradation of the extracellular matrix ⁶² Show member pathways Collagen degradation ⁶² Extracellular matrix organization ⁶²	12.68	BMP2 FGF2 LTBP1 PCOLCE TGFB1
12	Pathways in cancer ³⁶	12.63	BMP2 FGF2 IL2 IL3 LRP5 STAT3
13	p70S6K Signaling ⁶⁰ Show member pathways mTOR Pathway ⁶⁰ Renin-Angiotensin Pathway ⁶⁰	12.49	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
14	Human Embryonic Stem Cell Pluripotency ⁶⁰ Show member pathways Factors Promoting Cardiogenesis in Vertebrates ⁶⁰	12.42	BMP2 FGF2 MYH7 TGFB1
15	Proteoglycans in cancer ³⁶	12.18	CAV1 FGF2 STAT3 TGFB1 TLR4
16	Colorectal Cancer Metastasis ⁶⁰	12.14	LRP5 STAT3 TGFB1 TLR4
17	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	12.11	FGF2 LRP5 STAT3 TGFB1
18	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶¹	12.02	FGF2 IL3 STAT3 TGFB1
19	Senescence and Autophagy in Cancer ¹	11.88	BMP2 IL3 TGFB1
20	IL27-mediated signaling events ¹ Show member pathways IL-12 Family Signaling Pathways ⁶¹ Interleukin-12 signaling ⁶² Th1 Differentiation Pathway ⁶¹	11.85	IL2 STAT3 TGFB1 TLR4
21	NF-KappaB Family Pathway ⁶⁰ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁰	11.84	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
22	Corticotropin-releasing hormone signaling pathway ¹	11.81	IL2 TGFB1 TLR4
23	Cytokine production by Th17 cells in CF (Mouse model) ²¹ Show member pathways Cytokine production by Th17 cells in CF ²¹	11.81	STAT3 TGFB1 TLR4
24	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶¹	11.79	BGLAP BMP2 FGF2 TGFB1
25	Angiogenesis (CST) ⁴	11.78	FGF2 TGFB1 TGFBR3
26	TGF-beta signaling pathway (KEGG) ³⁶	11.75	BMP2 LTBP1 TGFB1
27	Th17 Differentiation Pathway ⁶¹ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶¹	11.75	STAT3 TGFB1 TGFBR3 TLR4
28	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.69	LRP5 TGFB1 TLR4
29	Elastic fibre formation ⁶² Show member pathways Molecules associated with elastic fibres ⁶²	11.68	BMP2 LTBP1 TGFB1
30	TGF-beta receptor signaling (Pathway Interaction Database) ¹	11.51	CAV1 TGFB1 TGFBR3
31	Cell adhesion_Plasmin signaling ²¹	11.49	FGF2 TGFB1 TGFBR3
32	Differentiation Pathway ¹	11.47	FGF2 IL3 TGFB1
33	TGF-beta Receptor Signaling (WikiPathways) ¹	11.47	LTBP1 STAT3 TGFB1 TGFBR3
34	Interleukin-11 Signaling Pathway ¹	11.42	BGLAP STAT3 TGFB1
35	Cytokines and Inflammatory Response ¹	11.21	IL2 IL3 TGFB1
36	IL12 signaling mediated by STAT4 ¹	11.17	IL2 STAT3 TGFB1
37	G-protein signaling_Rap2B regulation pathway ²¹	10.88	BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
38	TFs Regulate miRNAs related to cardiac hypertrophy ¹	10.74	STAT3 TGFB1

Sources

GO Terms for Bone Fracture

Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.7	BGLAP BMP2 CRP CRTAC1 FGF2 IL2
2	extracellular space	GO:0005615	9.32	BGLAP BMP2 CRP FGF2 IL2 IL3

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	MAPK cascade	GO:0000165	9.92	FGF2 IL2 IL3 TGFB1
2	inflammatory response	GO:0006954	9.88	BMP2 CRP STAT3 TGFB1 TLR4
3	positive regulation of cell proliferation	GO:0008284	9.88	FGF2 IL2 IL3 LRP5 STAT3 TGFB1
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.83	BMP2 FGF2 TGFB1 TLR4
5	regulation of receptor activity	GO:0010469	9.8	BMP2 FGF2 IL2 IL3 NUDT6 TGFB1
6	BMP signaling pathway	GO:0030509	9.77	BMP2 TGFB1 TGFBR3
7	cellular response to organic cyclic compound	GO:0071407	9.74	BMP2 STAT3 TGFB1
8	negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	9.73	CAV1 TGFB1 TGFBR3
9	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.72	IL2 IL3 STAT3
10	somatic stem cell population maintenance	GO:0035019	9.71	FGF2 LRP5 STAT3
11	cellular response to growth factor stimulus	GO:0071363	9.69	BGLAP BMP2 TGFB1
12	hyaluronan catabolic process	GO:0030214	9.64	FGF2 TGFB1
13	regulation of regulatory T cell differentiation	GO:0045589	9.63	IL2 TGFB1
14	positive regulation of superoxide anion generation	GO:0032930	9.63	CRP TGFB1
15	positive regulation of gene expression	GO:0010628	9.63	BMP2 CAV1 CRP STAT3 TGFB1 TLR4
16	cardiac epithelial to mesenchymal transition	GO:0060317	9.62	BMP2 TGFBR3
17	positive regulation of interleukin-17 production	GO:0032740	9.61	IL2 TGFB1
18	positive regulation of peptidase activity	GO:0010952	9.61	CAV1 PCOLCE
19	epithelial to mesenchymal transition	GO:0001837	9.61	BMP2 TGFB1 TGFBR3
20	positive regulation of osteoblast proliferation	GO:0033690	9.59	BMP2 LRP5
21	negative regulation of interleukin-17 production	GO:0032700	9.58	TGFB1 TLR4
22	positive regulation of regulatory T cell differentiation	GO:0045591	9.58	IL2 TGFB1
23	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.54	MYH7 TGFB1 TGFBR3
24	positive regulation of odontogenesis	GO:0042482	9.46	BMP2 TGFB1
25	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.43	BMP2 STAT3 TGFB1
26	response to hypoxia	GO:0001666	9.35	BMP2 CAV1 MB TGFB1 TGFBR3
27	pathway-restricted SMAD protein phosphorylation	GO:0060389	8.8	BMP2 TGFB1 TGFBR3
28	positive regulation of transcription by RNA polymerase II	GO:0045944	10.04	BMP2 FGF2 IL2 LRP5 STAT3 TGFB1

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activator activity	GO:0016504	9.37	CAV1 PCOLCE
2	cytokine activity	GO:0005125	9.35	BMP2 FGF2 IL2 IL3 TGFB1
3	transforming growth factor beta receptor binding	GO:0005160	9.33	BMP2 TGFB1 TGFBR3
4	type II transforming growth factor beta receptor binding	GO:0005114	9.32	TGFB1 TGFBR3
5	transforming growth factor beta-activated receptor activity	GO:0005024	9.26	LTBP1 TGFBR3
6	growth factor activity	GO:0008083	9.1	BMP2 FGF2 IL2 IL3 NUDT6 TGFB1

Sources

Sources for Bone Fracture

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ Genetics Home Reference

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HGMD

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ MalaCards

³⁹ MedGen

⁴⁰ MedlinePlus

⁴¹ MeSH

⁴² MESH via Orphanet

⁴³ MGI

⁴⁴ NCBI Bookshelf

⁴⁵ NCI

⁴⁶ NCIt

⁴⁷ NDF-RT

⁴⁸ NIH Clinical Center

⁴⁹ NIH Rare Diseases

⁵⁰ NINDS

⁵¹ Novoseek

⁵² Novus Biologicals

⁵³ OMIM

⁵⁴ OMIM via Orphanet

⁵⁵ Orphanet

⁵⁶ PathCards

⁵⁷ PharmGKB

⁵⁸ PubMed

⁵⁹ PubMed Health

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via HPO

⁶⁶ SNOMED-CT via Orphanet

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ UniProtKB/Swiss-Prot

⁷² Wikipedia