MCID: BNF002
MIFTS: 55

Bone Fracture malady

Bone diseases category

Summaries for Bone Fracture

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63Wikipedia, 32MalaCards
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Wikipedia:63 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards: Bone Fracture is related to osteoporosis and obesity. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are MIF Action Through Endocytic Pathway and Crosslinking of collagen fibrils. The compounds procollagen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Bone Fracture

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30LifeMap Discovery™, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone fracture 30 44


Related Diseases for Bone Fracture

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17GeneCards, 18GeneDecks
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Diseases related to Bone Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.6COL1A1, BGLAP, CALCA, BMP2, ESR2
2obesity30.3CAV1
3bone carcinoma30.3BMP2, CAV1, BGLAP
4hepatitis30.2CAV1
5hyperparathyroidism30.2BGLAP, CALCA
6diabetes mellitus30.0ESR2, CD14, BMP2, CALCA, BGLAP
7prostate cancer30.0ESR2, BMP2, CAV1, BGLAP
8breast cancer30.0CALCA, CAV1, PDGFA, BMP2, NUDT6, CD14
9celiac disease29.8LCT
10thyroiditis29.8CALCA
11parathyroid adenoma29.8CALCA
12vascular disease29.8MB
13myocardial infarction29.8MB, CD14
14liver cirrhosis29.8PDGFA, CD14
15osteitis fibrosa29.8BGLAP
16osteogenesis imperfecta type i29.8BGLAP, COL1A1
17myeloma29.8CD14, BMP2, BGLAP
18sarcoma29.8CAV1, PDGFA, MB, BMP2
19adenoma29.8CALCA, CAV1, TLR4, NUDT6, ESR2
20leukemia29.8CAV1, TLR4, BMP2, NUDT6, CD14, ESR2
21facial paralysis10.4
22osteoporotic fracture10.3
23spinal muscular atrophy type 1 with congenital bone fractures10.2
24cervicitis10.1
25meningitis10.1
26neuropathy10.1
27primary hyperparathyroidism10.1
28cerebritis10.1
29pharyngitis10.1
30cerebrotendinous xanthomatosis10.1
31hepatocellular carcinoma10.1
32hypogonadism10.1
33prostatitis10.1
34tuberculosis10.1
35xanthomatosis10.1
36pancreatitis10.0CELA3B
37periodontitis10.0TLR4
38galactosemia10.0TLR4
39inflammatory bowel disease10.0TLR4
40myocarditis10.0MB
41endometriosis10.0ESR2
42muscular dystrophy10.0ANO5
43giant cell tumor10.0CALCA
44peritonitis10.0CD14, MB
45osteomyelitis10.0BMP2
46diarrhea10.0CALCA, LCT
47osteogenesis imperfecta10.0BGLAP, COL1A1
48thyroid cancer10.0CALCA, BGLAP
49coronary heart disease10.0MB, TLR4
50paget's disease of bone10.0BGLAP, CALCA

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Clinical Features for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bone Fracture

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Search CenterWatch for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Bone Fracture:

32
Bone, Bone marrow, Breast, Liver, Kidney, Spinal cord, Brain, Prostate, Endothelial, Skeletal muscle, Myeloid, B cells, Testes, Eye, Thyroid, Pancreas, Lung, Lymph node, Cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bone Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2PCOLCE, SMN1
2MP:000538810.2CAV1, MB, ESR2
3MP:000537710.1TLR4, BMP2, ESR2, SMN1
4MP:00053909.9SMN1, ESR2, PCOLCE, CD14, BMP2, PDGFA
5MP:00053759.7ESR2, CD14, TLR4, CAV1, COL1A1
6MP:00053699.6CAV1, TLR4, PDGFA, MB, PCOLCE, ESR2
7MP:00107719.3COL1A1, CALCA, CAV1, TLR4, PDGFA, IL1RAP
8MP:00053859.2COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
9MP:00053768.9COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
10MP:00036318.8COL1A1, CALCA, CAV1, TLR4, PDGFA, BMP2

Publications for Bone Fracture

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50PubMed
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Articles related to Bone Fracture:

(show top 50)    (show all 871)
idTitleAuthorsYear
1
Trabecular Bone Score (TBS) Predicts Vertebral Fractures in Japanese Women Over 10 Years Independently of Bone Density and Prevalent Vertebral Deformity: The Japanese Population-Based Osteoporosis (JPOS) Cohort Study. (23873699)
2014
2
Knee osteoarthritis is associated with increased prevalence of vertebral fractures despite high systemic bone mineral density: a cross-sectional study in an Asian population. (24261775)
2014
3
Bone diseases. Incident fractures during treatment for osteoporosis. (23938864)
2013
4
Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk. (23203458)
2013
5
Outcomes and complication rates of different bone grafting modalities in long bone fracture nonunions: a retrospective cohort study in 182 patients. (24016227)
2013
6
The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women. (22798246)
2013
7
Bone mineral density status and frequency of osteoporosis and clinical fractures in 155 patients with psoriatic arthritis followed in a university hospital. (24055256)
2013
8
Spinal bone defects in neurofibromatosis type I with dural ectasia: stress fractures or dysplastic? A case series. (23812245)
2013
9
Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral skeleton. (22896024)
2012
10
Hepatic osteodystrophy complicated with bone fracture in early infants with biliary atresia. (23293713)
2012
11
Elevated local TGF-I^1 level predisposes a closed bone fracture to tuberculosis infection. (22738905)
2012
12
Bone mass, bone markers and prevalence of fractures in adults with osteogenesis imperfecta. (22207876)
2011
13
An extravehicular suit impact load attenuation study to improve astronaut bone fracture prediction. (21485404)
2011
14
Disseminated tuberculosis complicated with tuberculous meningitis, miliary tuberculosis, and thoracal bone fracture while investigating a cervical lymphadenopathy. Tuberculosis: a hidden enemy? (20672504)
2010
15
Increased concentrations of prostaglandin D2 during post-fracture bone remodeling. (20080921)
2010
16
Cigarette smoking decreases TGF-b1 serum concentrations after long bone fracture. (20471641)
2010
17
HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture. (20844427)
2010
18
Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. (19641839)
2009
19
Evaluation of a single miniplate use in treatment of zygomatic bone fracture. (19816265)
2009
20
Hyponatremia associated with large-bone fracture in elderly patients. (19472069)
2009
21
Bone fracture: When the cracks begin to show. (18654582)
2008
22
Association between alcohol consumption and both osteoporotic fracture and bone density. (18456037)
2008
23
The RIZ Pro704 insertion-deletion polymorphism, bone mineral density and fracture risk: the Rotterdam study. (18037365)
2008
24
Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture. (18388308)
2008
25
Central tarsal bone fracture in the border collie. (17490445)
2007
26
The application of the cell method in a clinical assessment of bone fracture risk. (18421941)
2007
27
Correlation between the content of transforming growth factor-beta 1, interleukin-1 beta and collagenase activity in proximal femur bone samples obtained from patients with femoral neck fracture]. (16294696)
2005
28
Experimental study and clinical observation of minimum-contact plate in long bone fracture. (15769310)
2005
29
Pneumolabyrinth: an unusual finding in a temporal bone fracture. (12697360)
2003
30
Temporal bone fracture and latent meningitis: temporal bone histopathology study of the month. (12806310)
2003
31
The biomechanical environment of a bone fracture and its influence upon the morphology of healing. (12787983)
2003
32
Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. (11886765)
2002
33
Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K. (11368299)
2001
34
The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture--an FEM study. (10768390)
2000
35
Dysphagia secondary to iatrogenic hyoid bone fracture. (11045199)
2000
36
Vacuum phenomenon in posttraumatic nonunion of pubic bone fracture. (9888787)
1999
37
What happens to vitamin K(1) in serum after bone fracture? (10585362)
1999
38
Nociceptive atrophy of the rat soleus muscle induced by bone fracture: a morphometric study. (9049736)
1997
39
Fracture through the bone of traumatic myositis ossificans. A report of three cases. (8027150)
1994
40
Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose-response study. (1393035)
1992
41
Conservative management of fourth tarsal bone fracture in a draft horse. (1429130)
1992
42
Partially biodegradable polyacrylic-polyester composites for internal bone fracture fixation. (1878459)
1991
43
A neural network approach for bone fracture healing assessment. (18238343)
1990
44
Unicameral bone cyst with fracture. (4094995)
1985
45
Vestibular syndrome associated with temporohyoid joint fusion and temporal bone fracture in three horses. (6333418)
1984
46
The dynamics of bone fracture: from a materials viewpoint [proceedings]. (922195)
1977
47
Relationship of pelvic bone fracture patterns to injuries of urethra and bladder. (5689611)
1968
48
Effect of vitamin D2 and fluoride on experimental bone fracture healing in rats. (5298503)
1967
49
Some Cases of Fracture of Long Bones from Slight Causes in connection with Tabes Dorsalis, Syphilis, and Paraplegia. (20896824)
1893
50
A Case of Fracture of both Bones of the Leg, occasioned by a very slight cause, in a Woman the Subject of Tabes Dorsalis. (20896825)
1893

Genetic Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD14, TLR4
210.2COL1A1, PCOLCE
310.1CD14, TLR4, COL1A1
4
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10.0IL1RAP, CD14, TLR4
510.0TLR4, CD14, IL1RAP
6
Immune response Bacterial infections in normal airways
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10.0TLR4, CD14, IL1RAP
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.0CALCA, BGLAP, COL1A1
8
Hide members
9.9NUDT6, BMP2, PDGFA, TLR4
9
Cell adhesion Integrin-mediated cell adhesion and migration
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9.9MYH2, MYH7, CAV1, COL1A1
10
Hide members
9.9PCOLCE, BMP2, PDGFA, COL1A1
11
Hide members
9.8PDGFA, BMP2, MYH7, MYH2, NUDT6
12
Hide members
9.7CAV1, PDGFA, BMP2, NUDT6, ESR2
13
Hide members
9.5ESR2, COL1A1, PDGFA, BMP2, MYH7, MYH2

Compounds for genes affiliated with Bone Fracture

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1procollagen4410.8PCOLCE
2pge24410.6MB, COL1A1
3monophosphoryl lipid a4410.5TLR4, CD14
4alizarin red s4410.5BGLAP, BMP2
5cycloheximide4410.5PDGFA, CAV1
6calcium gluconate4410.5CALCA, BGLAP
7ipriflavone4410.5CALCA, BGLAP
8methylmethacrylate4410.5MB, BMP2
9chitosan4410.4MB, BMP2, BGLAP
10tio24410.4BMP2, BGLAP
11zoledronic acid4410.4CALCA, BGLAP, BMP2
12glucuronoxylomannan4410.4TLR4, CD14
13alendronate44 49 1112.4BMP2, BGLAP, CALCA
14glycolipid4410.3CD14, TLR4, CAV1
15alginate4410.3BMP2, BGLAP, MB
16glutamate4410.3MYH7, MB
17carbohydrates4410.3MB, TLR4, LCT, CD14
18fluoride4410.3BGLAP, CALCA, MB
19hydrocortisone44 2 59 1113.3CD14, BGLAP, LCT, CALCA
20acetylcholine44 49 28 11 2414.3NUDT6, MB, CAV1, CALCA
21raloxifene44 28 49 1113.3BGLAP, ESR2, CALCA, BMP2
22hydroxyproline44 11 2412.2COL1A1, CALCA, BGLAP
23calcitriol44 59 11 2413.2CALCA, BMP2, CD14, TLR4, BGLAP
241,25 dihydroxy vitamin d34410.2BMP2, BGLAP, COL1A1, CD14, CALCA
25etidronate4410.2CALCA, BGLAP
26wortmannin4410.2CAV1, TLR4, BMP2, NUDT6, CD14
27creatinine4410.1BGLAP, CD14, MYH7, BMP2, MB
28dopamine44 28 11 2413.1BMP2, NUDT6, MB, ESR2
29simvastatin44 49 59 28 11 2415.1CAV1, BMP2, BGLAP, COL1A1, TLR4
30lactate4410.1NUDT6, CD14, BMP2, CALCA, TLR4, MB
31teriparatide44 1111.1BGLAP, CALCA
32ribonucleic acid4410.0ESR2, BMP2, SMN1, COL1A1, PDGFA, NUDT6
33guanidine hydrochloride4410.0BGLAP, BMP2, MB
34cyclosporin a44 28 5912.0BGLAP, CAV1, TLR4, BMP2, CALCA, CD14
35paraffin449.9ESR2, CD14, MB, PDGFA, CAV1, BGLAP
36alfacalcidol44 59 1111.9CALCA, BGLAP
37oligonucleotide449.9COL1A1, CAV1, SMN1, CD14, MYH7, BMP2
38heparin44 28 11 2412.9BGLAP, LCT, MB, CD14, CAV1, PDGFA
39testosterone44 59 11 2412.9BGLAP, CALCA, CAV1, ESR2, NUDT6, BMP2
40alanine449.8TLR4, COL1A1, BGLAP, CAV1, CD14, BMP2
41aspartate449.8MB, TLR4, BGLAP, CD14, COL1A1
42nitric oxide44 11 2411.8CAV1, TLR4, BMP2, NUDT6, IL1RAP, CALCA
43serine449.7ESR2, CAV1, NUDT6, TLR4, BMP2, MYH7
44retinoic acid44 2410.6PDGFA, NUDT6, CAV1, BMP2, BGLAP, COL1A1
45vitamin d449.6TLR4, CALCA, PDGFA, BMP2, CD14, ESR2
46dexamethasone44 49 28 1112.5BGLAP, ESR2, CD14, BMP2, PDGFA, TLR4
47arginine449.5MYH7, NUDT6, CD14, COL1A1, BMP2, MB
48cysteine449.4NUDT6, CD14, ESR2, BMP2, MB, TLR4
49vegf449.3BGLAP, CAV1, TLR4, ESR2, CD14, NUDT6
50calcium44 49 11 2412.0MYH2, COL1A1, CD14, NUDT6, CALCA, MYH7

GO Terms for genes affiliated with Bone Fracture

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16Gene Ontology
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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:03298210.2MYH2, MYH7
2muscle myosin complexGO:0058599.9MYH2, MYH7
3extracellular spaceGO:0056159.4COL1A1, BGLAP, CALCA, PDGFA, BMP2, CD14
4extracellular regionGO:0055769.0CELA3B, COL1A1, BGLAP, CALCA, PDGFA, BMP2

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3CD14, TLR4
2positive regulation of ossificationGO:04577810.2BMP2, CALCA
3cytosolic calcium ion homeostasisGO:05148010.2CAV1, CALCA
4osteoblast differentiationGO:00164910.1COL1A1, BGLAP, BMP2
5response to hypoxiaGO:00166610.0BMP2, MB, PDGFA, CAV1
6cell-cell signalingGO:0072679.9CALCA, PDGFA, BMP2, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.9TLR4, PDGFA, BMP2
8inflammatory responseGO:0069549.6IL1RAP, CD14, BMP2, CALCA

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, TLR4
2peptidase activator activityGO:01650410.1PCOLCE, CAV1
3platelet-derived growth factor bindingGO:0484079.8PDGFA, COL1A1

Products for genes affiliated with Bone Fracture

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Sources for Bone Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet