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MCID: BNF002
MIFTS: 53

Bone Fracture malady

Bone category
37 genes, 26 tissues, 121 related diseases, clinical trials.

Summaries for Bone Fracture

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64Wikipedia, 33MalaCards
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Wikipedia:64 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards: Bone Fracture is related to osteoporosis and bone carcinoma. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are MIF Action Through Endocytic Pathway and Crosslinking of collagen fibrils. The compounds procollagen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Bone Fracture

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31LifeMap Discovery™, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

bone fracture 31 45


Related Diseases for Bone Fracture

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bone Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.7COL1A1, BGLAP, CALCA, BMP2, ESR2
2bone carcinoma30.3BMP2, CAV1, BGLAP
3osteoporosis, postmenopausal30.1COL1A1, BGLAP, CALCA, ESR2
4celiac disease29.9LCT
5vascular disease29.9MB
6osteitis fibrosa29.9BGLAP
7osteogenesis imperfecta type i29.9BGLAP, COL1A1
8adenoma29.9CALCA, CAV1, TLR4, NUDT6, ESR2
9osteoporotic fracture10.3
10spinal muscular atrophy type 1 with congenital bone fractures10.3
11hepatitis c10.1
12primary hyperparathyroidism10.1
13hepatitis b10.1
14cerebrotendinous xanthomatosis10.1
15tuberculosis10.1
16xanthomatosis10.1
17brain injury10.1
18head injury10.1
19traumatic brain injury10.1
20hepatitis c virus10.1
21pancreatitis10.0CELA3B
22periodontitis10.0TLR4
23galactosemia10.0TLR4
24inflammatory bowel disease10.0TLR4
25myocarditis10.0MB
26endometriosis10.0ESR2
27muscular dystrophy10.0ANO5
28giant cell tumor10.0CALCA
29thyroiditis10.0CALCA
30parathyroid adenoma10.0CALCA
31peritonitis10.0CD14, MB
32myocardial infarction10.0MB, CD14
33osteomyelitis10.0BMP2
34diarrhea10.0CALCA, LCT
35osteogenesis imperfecta10.0BGLAP, COL1A1
36obesity10.0CAV1
37thyroid cancer10.0CALCA, BGLAP
38hepatitis10.0CAV1
39hyperparathyroidism10.0BGLAP, CALCA
40liver cirrhosis10.0PDGFA, CD14
41coronary heart disease10.0MB, TLR4
42paget's disease of bone10.0BGLAP, CALCA
43hypertension10.0CALCA, CAV1
44prolactinoma10.0ESR2
45acute myocardial infarction10.0MB, MYH7, CD14
46idiopathic juvenile osteoporosis10.0CALCA, BGLAP, COL1A1
47allergic rhinitis10.0CD14
48insulin resistance10.0TLR4, MB, ESR2
49myeloma10.0CD14, BMP2, BGLAP
50progressive osseous heteroplasia10.0BGLAP, BMP2

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Clinical Features for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Bone Fracture

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Search CenterWatch for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bone Fracture:
Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
Ovation
Stromal vascular fraction cells for osteoporotic bone fractures
Embryonic/Adult Cultured Cells Related to Bone Fracture:
Bone marrow-derived mesenchymal stem cells, PMID: 23180104
Stromal vascular fraction cells, PMIDs: 21605897, 16488036

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Bone Fracture:

33
Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Cortex, Skeletal muscle, Pancreas, Thyroid, Breast, Prostate, Myeloid, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Adrenal cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Bone Fracture:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
limbs/digits/tail phenotype
MP:000537110.2PCOLCE, SMN1
2
respiratory system phenotype
MP:000538810.2CAV1, MB, ESR2
3
hearing/vestibular/ear phenotype
MP:000537710.1TLR4, BMP2, ESR2, SMN1
4
skeleton phenotype
MP:00053909.9SMN1, ESR2, PCOLCE, CD14, BMP2, PDGFA
5
adipose tissue phenotype
MP:00053759.7ESR2, CD14, TLR4, CAV1, COL1A1
6
muscle phenotype
MP:00053699.6CAV1, TLR4, PDGFA, MB, PCOLCE, ESR2
7
integument phenotype
MP:00107719.3COL1A1, CALCA, CAV1, TLR4, PDGFA, IL1RAP
8
cardiovascular system phenotype
MP:00053859.2COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
9
homeostasis/metabolism phenotype
MP:00053768.9COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
10
nervous system phenotype
MP:00036318.8COL1A1, CALCA, CAV1, TLR4, PDGFA, BMP2

Publications for Bone Fracture

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Sources:
51PubMed
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Articles related to Bone Fracture:

(show top 50)    (show all 871)
idTitleAuthorsYear
1
Impact of osteoporosis and bone fracture on health-related quality of life in postmenopausal women. (23710562)
2014
2
Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)
2013
3
Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia. (23211577)
2013
4
A "complicated" fracture: a Philadelphia chromosome-positive myeloid sarcoma of the bone. (23404583)
2013
5
Partnership for fragility bone fracture care provision and prevention program (P4Bones): study protocol for a secondary fracture prevention pragmatic controlled trial. (23343392)
2013
6
Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD). (23286544)
2013
7
Pelvic bone fractures mimicking bone metastases in a patient with hepatitis B virus-associated liver cirrhosis and hepatocellular carcinoma. (23269891)
2012
8
Long-bone fracture pain management in the emergency department. (21435705)
2012
9
Case of bilateral pneumolabyrinth presenting as sudden, bilateral deafness, without temporal bone fracture, after a fall. (22583781)
2012
10
Best cases from the AFIP: Necrotic giant cell tumor of bone manifesting with pathologic fracture. (21257935)
2011
11
High speed insertion of bone fracture fixation pins: a finite element penetration model with experimental comparisons. (22042459)
2011
12
Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair. (20859259)
2011
13
Parapharyngeal cerebrospinal fluid collection: an unusual complication of temporal bone fracture. (21078219)
2011
14
Fat embolism syndrome in long bone fracture--clinical experience in a tertiary referral center in Taiwan. (20728851)
2010
15
Management of subtrochanteric femur fractures with internal fixation and recombinant human bone morphogenetic protein-7 in a patient with osteopetrosis: a case report. (20482845)
2010
16
Triage pain scales cannot predict analgesia provision to pediatric patients with long-bone fracture. (20466218)
2010
17
Evaluation of the potential clinical application of low-intensity ultrasound stimulation for preventing osteoporotic bone fracture. (20204699)
2010
18
Arthroscopic treatment of a fresh lunate bone fracture detaching the scapholunate ligament. (20299263)
2010
19
Play and players in bone fracture healing match. (22461167)
2009
20
Bone density and fragility fractures in patients with developmental disabilities. (18629564)
2009
21
Autologous ossiculoplasty following temporal bone fracture. (18452634)
2009
22
Polymorphisms of the WNT10B gene, bone mineral density, and fractures in postmenopausal women. (19458884)
2009
23
Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases. (18505375)
2008
24
Multiple genetic loci for bone mineral density and fractures. (18445777)
2008
25
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. (18455228)
2008
26
Cancellous bone lamellae strongly affect microcrack propagation and apparent mechanical properties: separation of patients with osteoporotic fracture from normal controls using a 2D nonlinear finite element method (biomechanical stereology). (18378204)
2008
27
Assessing the risk of bone fracture among postmenopausal women who are receiving adjuvant hormonal therapy for breast cancer. (17519070)
2007
28
Modelling the effects of different fracture geometries and healing stages on ultrasound signal loss across a long bone fracture. (17852180)
2007
29
Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry. (17602227)
2007
30
Reducing the Risk of Bone Fracture: A Review of the Research for Adults With Low Bone Density (23035316)
2005
31
Trabecular bone fracture healing simulation with finite element analysis and fuzzy logic. (16214492)
2005
32
Serum osteoprotegerin is a major determinant of bone density development and prevalent vertebral fracture status following cardiac transplantation. (12584041)
2003
33
Cochlear involvement in a temporal bone fracture. (14600482)
2003
34
A case of external carotid artery pseudoaneurysm from hyoid bone fracture. (12852515)
2003
35
Relation of androgen receptor gene polymorphism to bone mineral density and fracture risk in early postmenopausal women during a 5-year randomized hormone replacement therapy trial. (12568409)
2003
36
Bone morphogenetic protein-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. (12052447)
2002
37
Temporal bone fracture with displacement of bone. (11480294)
2001
38
Changes in bone and calcium metabolism following hip fracture in elderly patients. (11446559)
2001
39
Studies of bone density, quantitative ultrasound, and vertebral fractures in relation to collagen type I alpha 1 alleles in elderly women. (11685422)
2001
40
Salmon calcitonin in osteoporosis. The effect of intranasal application on bone mineral content and fracture frequency in postmenopausal women with manifest osteoporotic changes]. (8346588)
1993
41
Air in the temporomandibular joint fossa: CT sign of temporal bone fracture. (2068313)
1991
42
Estrogens, bone mass, and osteoporotic fracture. (1750409)
1991
43
The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. (2125994)
1990
44
Unicameral bone cyst of the second metatarsal with pathologic fracture. (3572764)
1987
45
Bone fracture consolidates faster with low-power laser. (3573935)
1987
46
Bone fracture in elderly female with primary hyperparathyroidism: relationship among renal function, vitamin D status and fracture risk. (3583226)
1987
47
Disuse osteopaenia predisposing to a long bone fracture in a horse. (4076150)
1985
48
The influence of non-specific vaccines on serum calcium after bone fracture. (6775985)
1980
49
Hematological and metabolic effects of calcium and vitamin D deficiency and bone fracture in rats. (4533569)
1974
50
PEPTIDASE ACTIVITY IN HUMAN SERUM FOLLOWING BONE FRACTURE. (16695693)
1949

Genetic Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Sources:
52QIAGEN, 54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
MIF Action Through Endocytic Pathway52
10.2CD14, TLR4
2
Crosslinking of collagen fibrils54
10.2COL1A1, PCOLCE
3
Amoebiasis30
10.1CD14, TLR4, COL1A1
4
Toll Comparative Pathway52
Hide members
10.0IL1RAP, CD14, TLR4
5
Transcription NF-kB signaling pathway12
10.0TLR4, CD14, IL1RAP
6
Immune response Bacterial infections in normal airways
Hide members
10.0TLR4, CD14, IL1RAP
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.0CALCA, BGLAP, COL1A1
8
NF-KappaB Family Pathway52
Hide members
9.9NUDT6, BMP2, PDGFA, TLR4
9
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
9.9MYH2, MYH7, CAV1, COL1A1
10
Collagen biosynthesis and modifying enzymes54
Hide members
9.9PCOLCE, BMP2, PDGFA, COL1A1
11
PAK Pathway52
Hide members
9.8PDGFA, BMP2, MYH7, MYH2, NUDT6
12
Nanog in Mammalian ESC Pluripotency52
Hide members
9.7CAV1, PDGFA, BMP2, NUDT6, ESR2
13
Rho Family GTPases52
Hide members
9.5ESR2, COL1A1, PDGFA, BMP2, MYH7, MYH2

Compounds for genes affiliated with Bone Fracture

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Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1procollagen4510.8PCOLCE
2pge24510.6COL1A1, MB
3monophosphoryl lipid a4510.5TLR4, CD14
4alizarin red s4510.5BMP2, BGLAP
5cycloheximide4510.5CAV1, PDGFA
6calcium gluconate4510.5BGLAP, CALCA
7ipriflavone4510.5BGLAP, CALCA
8methylmethacrylate4510.4BMP2, MB
9tio24510.4BMP2, BGLAP
10chitosan4510.4BGLAP, MB, BMP2
11zoledronic acid4510.4BGLAP, CALCA, BMP2
12glucuronoxylomannan4510.4CD14, TLR4
13alendronate45 50 1112.4BGLAP, CALCA, BMP2
14glycolipid4510.3CAV1, TLR4, CD14
15alginate4510.3BMP2, MB, BGLAP
16glutamate4510.3MB, MYH7
17carbohydrates4510.3LCT, TLR4, MB, CD14
18fluoride4510.3MB, CALCA, BGLAP
19hydrocortisone45 2 60 1113.3CD14, CALCA, LCT, BGLAP
20acetylcholine45 50 29 11 2414.3NUDT6, MB, CAV1, CALCA
21raloxifene45 29 50 1113.3ESR2, BMP2, CALCA, BGLAP
22hydroxyproline45 11 2412.2CALCA, BGLAP, COL1A1
23calcitriol45 60 11 2413.2BGLAP, CALCA, TLR4, BMP2, CD14
241,25 dihydroxy vitamin d34510.2COL1A1, BGLAP, CALCA, BMP2, CD14
25alfacalcidol45 60 1112.2CALCA, BGLAP
26wortmannin4510.2CD14, NUDT6, BMP2, TLR4, CAV1
27creatinine4510.1CD14, MYH7, BMP2, MB, BGLAP
28dopamine45 29 11 2413.1MB, BMP2, NUDT6, ESR2
29simvastatin45 50 60 29 11 2415.1COL1A1, BGLAP, CAV1, TLR4, BMP2
30lactate4510.1CALCA, TLR4, MB, BMP2, NUDT6, CD14
3124,25-dihydroxyvitamin d34510.1CALCA, BGLAP
32ribonucleic acid4510.0COL1A1, PDGFA, BMP2, NUDT6, ESR2, SMN1
33guanidine hydrochloride4510.0BGLAP, MB, BMP2
34cyclosporin a45 29 6012.0BGLAP, CALCA, CAV1, TLR4, BMP2, CD14
35paraffin459.9BGLAP, CAV1, PDGFA, MB, CD14, ESR2
36teriparatide45 1110.9CALCA, BGLAP
37oligonucleotide459.9COL1A1, CAV1, PDGFA, BMP2, MYH7, CD14
38heparin45 29 11 2412.9BGLAP, LCT, CAV1, PDGFA, MB, BMP2
39testosterone45 60 11 2412.9BGLAP, CALCA, CAV1, MB, BMP2, NUDT6
40alanine459.8COL1A1, BGLAP, CAV1, TLR4, MB, BMP2
41aspartate459.8CD14, MB, TLR4, BGLAP, COL1A1
42nitric oxide45 11 2411.8CALCA, CAV1, TLR4, BMP2, NUDT6, IL1RAP
43serine459.7BGLAP, CAV1, TLR4, MB, BMP2, MYH7
44retinoic acid45 2410.6COL1A1, BGLAP, CAV1, TLR4, PDGFA, BMP2
45vitamin d459.6ESR2, COL1A1, BGLAP, CALCA, CAV1, TLR4
46dexamethasone45 50 29 1112.5COL1A1, BGLAP, CAV1, TLR4, PDGFA, BMP2
47arginine459.5COL1A1, BGLAP, CAV1, MB, BMP2, MYH7
48cysteine459.4CAV1, LCT, BGLAP, COL1A1, TLR4, MB
49vegf459.3COL1A1, BGLAP, CALCA, CAV1, TLR4, PDGFA
50calcium45 50 11 2412.0TLR4, CAV1, CALCA, LCT, BGLAP, COL1A1

GO Terms for genes affiliated with Bone Fracture

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Sources:
16Gene Ontology
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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:03298210.2MYH2, MYH7
2muscle myosin complexGO:0058599.9MYH2, MYH7
3extracellular spaceGO:0056159.4COL1A1, BGLAP, CALCA, PDGFA, BMP2, CD14
4extracellular regionGO:0055769.0CELA3B, COL1A1, BGLAP, CALCA, PDGFA, BMP2

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3CD14, TLR4
2positive regulation of ossificationGO:04577810.2BMP2, CALCA
3cytosolic calcium ion homeostasisGO:05148010.2CAV1, CALCA
4osteoblast differentiationGO:00164910.1COL1A1, BGLAP, BMP2
5response to hypoxiaGO:00166610.0BMP2, MB, PDGFA, CAV1
6cell-cell signalingGO:0072679.9CALCA, PDGFA, BMP2, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.9TLR4, PDGFA, BMP2
8inflammatory responseGO:0069549.6IL1RAP, CD14, BMP2, CALCA

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, TLR4
2peptidase activator activityGO:01650410.1PCOLCE, CAV1
3platelet-derived growth factor bindingGO:0484079.8PDGFA, COL1A1

Products for genes affiliated with Bone Fracture

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  • Antibodies
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  • Antibodies

Sources for Bone Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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