MCID: BNF002
MIFTS: 55

Bone Fracture malady

Bone diseases category

Summaries for Bone Fracture

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63Wikipedia, 32MalaCards
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Wikipedia:63 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards: Bone Fracture is related to osteoporosis and obesity. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are MIF Action Through Endocytic Pathway and Crosslinking of collagen fibrils. The compounds procollagen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Bone Fracture

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30LifeMap Discovery™, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone fracture 30 44


Related Diseases for Bone Fracture

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bone Fracture via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.6COL1A1, BGLAP, CALCA, BMP2, ESR2
2obesity30.3CAV1
3bone carcinoma30.3BMP2, CAV1, BGLAP
4hepatitis30.2CAV1
5hyperparathyroidism30.2BGLAP, CALCA
6diabetes mellitus30.0ESR2, CD14, BMP2, CALCA, BGLAP
7prostate cancer30.0ESR2, BMP2, CAV1, BGLAP
8breast cancer30.0CALCA, CAV1, PDGFA, BMP2, NUDT6, CD14
9celiac disease29.8LCT
10thyroiditis29.8CALCA
11parathyroid adenoma29.8CALCA
12vascular disease29.8MB
13myocardial infarction29.8MB, CD14
14liver cirrhosis29.8PDGFA, CD14
15osteitis fibrosa29.8BGLAP
16osteogenesis imperfecta type i29.8BGLAP, COL1A1
17myeloma29.8CD14, BMP2, BGLAP
18sarcoma29.8CAV1, PDGFA, MB, BMP2
19adenoma29.8CALCA, CAV1, TLR4, NUDT6, ESR2
20leukemia29.8CAV1, TLR4, BMP2, NUDT6, CD14, ESR2
21facial paralysis10.4
22osteoporotic fracture10.3
23spinal muscular atrophy type 1 with congenital bone fractures10.2
24cervicitis10.1
25meningitis10.1
26neuropathy10.1
27primary hyperparathyroidism10.1
28cerebritis10.1
29pharyngitis10.1
30cerebrotendinous xanthomatosis10.1
31hepatocellular carcinoma10.1
32hypogonadism10.1
33prostatitis10.1
34tuberculosis10.1
35xanthomatosis10.1
36pancreatitis10.0CELA3B
37periodontitis10.0TLR4
38galactosemia10.0TLR4
39inflammatory bowel disease10.0TLR4
40myocarditis10.0MB
41endometriosis10.0ESR2
42muscular dystrophy10.0ANO5
43giant cell tumor10.0CALCA
44peritonitis10.0CD14, MB
45osteomyelitis10.0BMP2
46diarrhea10.0CALCA, LCT
47osteogenesis imperfecta10.0BGLAP, COL1A1
48thyroid cancer10.0CALCA, BGLAP
49coronary heart disease10.0MB, TLR4
50paget's disease of bone10.0BGLAP, CALCA

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Clinical Features for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bone Fracture

Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Search CenterWatch for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Bone Fracture:

32
Bone, Bone marrow, Breast, Liver, Kidney, Spinal cord, Brain, Prostate, Endothelial, Skeletal muscle, Myeloid, B cells, Testes, Eye, Thyroid, Pancreas, Lung, Lymph node, Cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bone Fracture:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2PCOLCE, SMN1
2MP:000538810.2CAV1, MB, ESR2
3MP:000537710.1TLR4, BMP2, ESR2, SMN1
4MP:00053909.9SMN1, ESR2, PCOLCE, CD14, BMP2, PDGFA
5MP:00053759.7ESR2, CD14, TLR4, CAV1, COL1A1
6MP:00053699.6CAV1, TLR4, PDGFA, MB, PCOLCE, ESR2
7MP:00107719.3COL1A1, CALCA, CAV1, TLR4, PDGFA, IL1RAP
8MP:00053859.2COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
9MP:00053768.9COL1A1, CALCA, CAV1, TLR4, PDGFA, MB
10MP:00036318.8COL1A1, CALCA, CAV1, TLR4, PDGFA, BMP2

Publications for Bone Fracture

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Sources:
50PubMed
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Articles related to Bone Fracture:

(show top 50)    (show all 871)
idTitleAuthorsYear
1
The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone. (24287938)
2014
2
High rates of death and hospitalization follow bone fracture among hemodialysis patients. (23903367)
2014
3
Management of maxillary alveolar bone fracture and severely intruded maxillary central incisor: report of a case. (22233224)
2013
4
Atypical bilateral stress fractures of the femoral shaft diagnosed by bone scintigraphy in a woman with osteoporosis. (24089064)
2013
5
Success of long bone fracture healing in ancient Egypt: a paleoepidemiological study of the Giza necropolis skeletons. (24304109)
2013
6
Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women. (23133532)
2012
7
Interleukin-1I+ gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people. (22868802)
2012
8
Vascular injury and concomitant long-bone fracture in war wounds. (23009831)
2012
9
Predicting the external formation of a bone fracture callus: an optimisation approach. (21614706)
2012
10
Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk. (22215184)
2012
11
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. (22792071)
2012
12
The usefulness of the endonasal incisional approach for the treatment of nasal bone fracture. (22783528)
2012
13
Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. (20445964)
2011
14
Towards an assessment of bone fracture healing using pulsed mode ultrasound. (21849736)
2011
15
Bone: fracture risk prediction--beyond BMD assessment. (21946894)
2011
16
Esthetic correction of depressed frontal bone fracture. (22442614)
2011
17
Conservative treatment in an isolated anterior wall frontal bone fracture in an elite soccer player. (20215897)
2010
18
Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. (20736794)
2010
19
Facial and vestibulocochlear nerve avulsion at the fundus of the internal auditory canal in a child without a temporal bone fracture. (20856161)
2010
20
Is there a role for bone morphogenetic proteins in osteoporotic fractures? (20082786)
2009
21
Hearing preserved traumatic delayed facial nerve paralysis without temporal bone fracture: neurosurgical perspective and experience in the management of 25 cases. (18440603)
2009
22
Identification of LTBP2 on chromosome 14q as a novel candidate gene for bone mineral density variation and fracture risk association. (18697872)
2008
23
Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. (17676991)
2007
24
The effect of parathyroidectomy on bone fracture risk in patients with primary hyperparathyroidism. (16983032)
2006
25
Increased bone fracture prevalence in postmenopausal women suffering from pollen-allergy. (16432646)
2006
26
Dystonia after a bone fracture of the arm in a patient with a history of striato-pallidal ischemic stroke: a case report. (15823486)
2005
27
Hyoid bone fracture from a gunshot wound. (15284578)
2004
28
Relationship between changes in biochemical markers of bone turnover and prediction value of fracture risk]. (15577130)
2004
29
The effects of calcitonin on acute bone loss after pertrochanteric fractures. A prospective, randomised trial. (15125121)
2004
30
Obscure temporal bone fracture with conductive hearing loss. (12619459)
2003
31
Effects of gender and age on the association of apolipoprotein E epsilon4 with bone mineral density, bone turnover and the risk of fractures in older people. (12195533)
2002
32
Interfragmentary surface area as an index of comminution energy: proof of concept in a bone fracture surrogate. (11858808)
2002
33
A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. (11285309)
2001
34
Pharmacological support of bone fracture healing. (18034144)
2000
35
Vitamin D receptor gene polymorphisms, bone mass, bone loss and prevalence of vertebral fracture: differences in postmenopausal women and men. (10525708)
1999
36
Stress fractures of the lateral metatarsal bones in metatarsus adductus foot deformity: a previously unrecognized association. (10653362)
1999
37
Changes in bone mass and bone turnover following distal forearm fracture. (10591838)
1999
38
Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone turnover rate. (9692078)
1998
39
Bone turnover and its relationship with bone mineral density in pre- and postmenopausal women with or without fractures. (9699199)
1998
40
Immediate and delayed nerve repair using freeze-thawed muscle allografts. Associated long-bone fracture. (9665526)
1998
41
Switch of osteonectin and osteopontin mRNA expression in the process of cartilage-to-bone transition during fracture repair. (9717566)
1998
42
Temporal bone fracture conductive hearing loss. (7867524)
1995
43
Diagnostic approach to reflex sympathetic dystrophy after fracture: radiography or bone scintigraphy? (8542905)
1995
44
Bone densitometry and osteoporotic fracture risk. (7942412)
1994
45
Effect of groove on bone fracture toughness. (1491024)
1992
46
Isolated hyoid bone fracture: a case report and review of the literature. (1994091)
1991
47
Facial bone fracture associated with carotid-cavernous sinus fistula. (2231801)
1990
48
Odontogenic infection leading to orbital cellulitis as a complication of fracture of the zygomatic bone. (3479446)
1987
49
Value of high-resolution computed tomography in diagnosis of petrous bone fracture. (3775632)
1986
50
Quantitative assessment of distraction and angulation following long bone fracture. (3988476)
1985

Genetic Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD14, TLR4
210.2COL1A1, PCOLCE
310.1CD14, TLR4, COL1A1
4
Hide members
10.0IL1RAP, CD14, TLR4
510.0TLR4, CD14, IL1RAP
6
Immune response Bacterial infections in normal airways
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10.0TLR4, CD14, IL1RAP
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.0CALCA, BGLAP, COL1A1
8
Hide members
9.9NUDT6, BMP2, PDGFA, TLR4
9
Cell adhesion Integrin-mediated cell adhesion and migration
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9.9MYH2, MYH7, CAV1, COL1A1
10
Hide members
9.9PCOLCE, BMP2, PDGFA, COL1A1
11
Hide members
9.8PDGFA, BMP2, MYH7, MYH2, NUDT6
12
Hide members
9.7CAV1, PDGFA, BMP2, NUDT6, ESR2
13
Hide members
9.5ESR2, COL1A1, PDGFA, BMP2, MYH7, MYH2

Compounds for genes affiliated with Bone Fracture

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1procollagen4410.8PCOLCE
2pge24410.6COL1A1, MB
3monophosphoryl lipid a4410.5CD14, TLR4
4alizarin red s4410.5BMP2, BGLAP
5cycloheximide4410.5CAV1, PDGFA
6ipriflavone4410.5CALCA, BGLAP
7calcium gluconate4410.5BGLAP, CALCA
8methylmethacrylate4410.5MB, BMP2
9chitosan4410.4BGLAP, MB, BMP2
10tio24410.4BMP2, BGLAP
11zoledronic acid4410.4BGLAP, CALCA, BMP2
12glucuronoxylomannan4410.4CD14, TLR4
13alendronate44 49 1112.4CALCA, BGLAP, BMP2
14glycolipid4410.3TLR4, CAV1, CD14
15alginate4410.3MB, BMP2, BGLAP
16glutamate4410.3MB, MYH7
17carbohydrates4410.3MB, CD14, TLR4, LCT
18fluoride4410.3BGLAP, CALCA, MB
19hydrocortisone44 2 59 1113.3LCT, CALCA, BGLAP, CD14
20acetylcholine44 49 28 11 2414.3CAV1, MB, NUDT6, CALCA
21raloxifene44 28 49 1113.3CALCA, BMP2, BGLAP, ESR2
22hydroxyproline44 11 2412.2BGLAP, COL1A1, CALCA
23calcitriol44 59 11 2413.2TLR4, CD14, BMP2, CALCA, BGLAP
241,25 dihydroxy vitamin d34410.2BGLAP, COL1A1, CALCA, BMP2, CD14
25etidronate4410.2BGLAP, CALCA
26wortmannin4410.2TLR4, BMP2, CD14, NUDT6, CAV1
27creatinine4410.1BMP2, MYH7, CD14, MB, BGLAP
28dopamine44 28 11 2413.1ESR2, NUDT6, BMP2, MB
29simvastatin44 49 59 28 11 2415.1CAV1, TLR4, BGLAP, COL1A1, BMP2
30lactate4410.1CALCA, NUDT6, BMP2, MB, TLR4, CD14
31teriparatide44 1111.1BGLAP, CALCA
32ribonucleic acid4410.0BMP2, ESR2, NUDT6, PDGFA, SMN1, COL1A1
33guanidine hydrochloride4410.0BMP2, MB, BGLAP
34cyclosporin a44 28 5912.0TLR4, CAV1, CALCA, CD14, BMP2, BGLAP
35paraffin449.9ESR2, CD14, MB, PDGFA, CAV1, BGLAP
3624,25-dihydroxyvitamin d3449.9CALCA, BGLAP
37oligonucleotide449.9CAV1, MYH7, BMP2, PDGFA, CD14, SMN1
38heparin44 28 11 2412.9LCT, CAV1, PDGFA, MB, CD14, BMP2
39testosterone44 59 11 2412.9BMP2, MB, CAV1, CALCA, BGLAP, ESR2
40alanine449.8BMP2, COL1A1, CD14, BGLAP, CAV1, TLR4
41aspartate449.8BGLAP, TLR4, COL1A1, CD14, MB
42nitric oxide44 11 2411.8CALCA, TLR4, CAV1, BMP2, NUDT6, IL1RAP
43serine449.7TLR4, BGLAP, MYH7, MB, BMP2, NUDT6
44retinoic acid44 2410.6ESR2, CD14, NUDT6, BMP2, COL1A1, BGLAP
45vitamin d449.6PDGFA, CD14, ESR2, CALCA, TLR4, CAV1
46dexamethasone44 49 28 1112.5COL1A1, TLR4, BMP2, CD14, IL1RAP, PDGFA
47arginine449.5CAV1, MB, COL1A1, ESR2, CD14, NUDT6
48cysteine449.4TLR4, CAV1, MB, BGLAP, COL1A1, LCT
49vegf449.3CD14, CALCA, CAV1, TLR4, PDGFA, BMP2
50calcium44 49 11 2412.0TLR4, CALCA, CD14, MYH2, NUDT6, MYH7

GO Terms for genes affiliated with Bone Fracture

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Sources:
16Gene Ontology
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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myosin filamentGO:03298210.2MYH2, MYH7
2muscle myosin complexGO:0058599.9MYH2, MYH7
3extracellular spaceGO:0056159.4COL1A1, BGLAP, CALCA, PDGFA, BMP2, CD14
4extracellular regionGO:0055769.0CELA3B, COL1A1, BGLAP, CALCA, PDGFA, BMP2

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:07122310.3CD14, TLR4
2positive regulation of ossificationGO:04577810.2BMP2, CALCA
3cytosolic calcium ion homeostasisGO:05148010.2CAV1, CALCA
4osteoblast differentiationGO:00164910.1COL1A1, BGLAP, BMP2
5response to hypoxiaGO:00166610.0BMP2, MB, PDGFA, CAV1
6cell-cell signalingGO:0072679.9CALCA, PDGFA, BMP2, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.9TLR4, PDGFA, BMP2
8inflammatory responseGO:0069549.6IL1RAP, CD14, BMP2, CALCA

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, TLR4
2peptidase activator activityGO:01650410.1PCOLCE, CAV1
3platelet-derived growth factor bindingGO:0484079.8PDGFA, COL1A1

Products for genes affiliated with Bone Fracture

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  • Antibodies
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  • Lysates
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Sources for Bone Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet