MCID: BNF002
MIFTS: 45

Bone Fracture malady

Bone diseases category
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Summaries for Bone Fracture

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Wikipedia:65 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

MalaCards based summary: Bone Fracture is related to prostate cancer and osteoporosis. An important gene associated with Bone Fracture is PCOLCE (procollagen C-endopeptidase enhancer), and among its related pathways are RhoGDI Pathway and Clathrin derived vesicle budding. The compounds (r)-(+)-blebbistatin and bts have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord.

Aliases & Classifications for Bone Fracture

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Bone Fracture, Aliases & Descriptions:

Name: Bone Fracture 30 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Related Diseases for Bone Fracture

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Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to bone fracture

Symptoms for Bone Fracture

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Drugs & Therapeutics for Bone Fracture

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Drug clinical trials:

Search ClinicalTrials for Bone Fracture

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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MalaCards organs/tissues related to Bone Fracture:

32
Bone, Brain, Spinal cord, Liver, Breast, Bone marrow, Skeletal muscle, Kidney, Prostate, Eye, Lymph node, Cortex, Lung, Thyroid, Testes, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Bone Fracture or affiliated genes

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Publications for Bone Fracture

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Articles related to Bone Fracture:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Plasma homocysteine, B vitamins and bone mineral density in osteoporosis: a possible risk for bone fracture. (25335377)
2014
2
The relationship between patient age and pain management of acute long-bone fracture in the ED. (25312220)
2014
3
Comparison study of the use of absorbable and nonabsorbable materials as internal splints after closed reduction for nasal bone fracture. (25075356)
2014
4
Bone Fracture Toughness and Strength Correlate with Collagen Cross-Link Maturity in a Dose-Controlled Lathyrism Mouse Model. (25213475)
2014
5
Temporal bone fracture causing superior semicircular canal dehiscence. (25295207)
2014
6
Bone fracture healing: Cell therapy in delayed unions and nonunions. (25093266)
2014
7
Automatic retrieval of bone fracture knowledge using natural language processing. (23053906)
2013
8
Circuit modeling of the electrical impedance: part III. Disuse following bone fracture. (23587651)
2013
9
Estimation of 10-year probability bone fracture in a selected sample of Palestinian people using fracture risk assessment tool. (24093559)
2013
10
Development of an ex vivo protocol to model bone fracture in laying hens resulting from collisions. (23785487)
2013
11
Bone fracture exacerbates murine ischemic cerebral injury. (23438676)
2013
12
Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing. (23937065)
2013
13
3D identification of trabecular bone fracture zone using an automatic image registration scheme: A validation study. (22682259)
2012
14
Cochlear implantation in posttraumatic bilateral temporal bone fracture. (22328130)
2012
15
Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. (21507568)
2011
16
Mechanisms of hyoid bone fracture after modelling: evaluation of anthropological criteria defining two relevant models. (21764532)
2011
17
Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. (20445964)
2011
18
A new approach to the treatment of nasal bone fracture: radiologic classification of nasal bone fractures and its clinical application. (21474225)
2011
19
Extranasal splint made of a polyethylene container: a distinct fixation method after nasal bone fracture reduction surgery. (21788804)
2011
20
A new approach to the treatment of nasal bone fracture: the clinical usefulness of closed reduction using a C-arm. (21317053)
2011
21
Bone mineral density and bone fracture in male patients receiving long-term suppressive levothyroxine treatment for differentiated thyroid carcinoma. (20960170)
2010
22
Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing. (20855498)
2010
23
Disseminated tuberculosis complicated with tuberculous meningitis, miliary tuberculosis, and thoracal bone fracture while investigating a cervical lymphadenopathy. Tuberculosis: a hidden enemy? (20672504)
2010
24
Comparison of the frequency of old septal deviation in patients with and without traumatic nasal bone fracture. (21287462)
2010
25
Time-frequency analysis to detect bone fracture in impact biomechanics. Application to the thorax. (19540145)
2009
26
Ultrasonic monitoring of bone fracture healing. (18599412)
2008
27
Temporal bone fracture with ossicular dislocation caused by a blow to the opposite side of the head. (17826019)
2008
28
Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. (17950532)
2007
29
Assessing the risk of bone fracture among postmenopausal women who are receiving adjuvant hormonal therapy for breast cancer. (17519070)
2007
30
Effect of long tubular bone fracture on serum levels of leptin, acute phase proteins and biochemical markers for organ functions]. (16464379)
2006
31
Obscure temporal bone fracture with conductive hearing loss. (12619459)
2003
32
Pneumolabyrinth: an unusual finding in a temporal bone fracture. (12697360)
2003
33
Efficacy of monitoring long-bone fracture healing by measurement of either bone stiffness or resonant frequency: numerical simulation. (11117288)
2000
34
Is exposure to HMG-CoA reductase inhibitors (statins), fibrates, or other lipid-lowering drugs associated with reduced risk of bone fracture in older patients? (11032211)
2000
35
Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer. (10971270)
2000
36
The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. (10027889)
1999
37
Vitamin D receptor genotype and the risk of bone fractures in women. (9730033)
1998
38
An interspecies comparison of bone fracture properties. (9713681)
1998
39
Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. (8231848)
1993
40
Principles of long bone fracture management. (1570435)
1992
41
Air in the temporomandibular joint fossa: CT sign of temporal bone fracture. (2068313)
1991
42
Electrostimulation and bone fracture healing. (2004532)
1991
43
The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue. (2125994)
1990
44
Histopathology of the facial nerve after longitudinal temporal bone fracture. (3386375)
1988
45
Pneumolabyrinth as a late sequela of temporal bone fracture. (3232721)
1988
46
Retardation of bone fracture healing in experimental diabetes. (3623654)
1987
47
A cumulative damage model for bone fracture. (3981298)
1985
48
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat. (6202957)
1984
49
The effects of pulsed magnetic fields of the type used in the stimulation of bone fracture healing. (6339155)
1983
50
Bilateral transverse temporal bone fracture: case report. (6038406)
1967

Variations for Bone Fracture

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Expression for genes affiliated with Bone Fracture

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Expression patterns in normal tissues for genes affiliated with Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for genes affiliated with Bone Fracture

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Pathways related to Bone Fracture according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4MYH2, MYH7
2
Show member pathways
9.4MYH2, MYH7
3
Show member pathways
9.4MYH2, MYH7
49.4MYH7, MYH2
5
Show member pathways
8.9NUDT6, MYH7, MYH2
6
Show member pathways
8.9MYH2, MYH7, NUDT6
7
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
8.9CAV1, MYH2, MYH7
8
Show member pathways
8.9MYH7, MYH2, CAV1

Compounds for genes affiliated with Bone Fracture

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Compounds related to Bone Fracture according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1(r)-(+)-blebbistatin619.7MYH7, MYH2
2bts619.7MYH7, MYH2
3(s)-(-)-blebbistatin619.7MYH7, MYH2
4(+-)-blebbistatin619.7MYH7, MYH2
5actomyosin449.7MYH2, MYH7
6gp 130449.5CAV1, MYH7
7procollagen449.5PCOLCE, BGLAP
8bromodeoxyuridine449.3MYH7, NUDT6
9caffeine44 28 2 50 24 1114.2NUDT6, BGLAP
10simvastatin44 50 61 28 24 1114.0BGLAP, CAV1
11glutamate448.9NUDT6, MYH7, CAV1
12testosterone44 61 24 1111.8BGLAP, NUDT6, CAV1
13atp44 289.8CAV1, MYH7, NUDT6
14vegf448.8CAV1, NUDT6, BGLAP
15retinoic acid44 249.3CAV1, NUDT6, BGLAP
16arginine448.3BGLAP, NUDT6, MYH7, CAV1
17cysteine448.3BGLAP, NUDT6, MYH7, CAV1
18serine448.2BGLAP, NUDT6, MYH7, CAV1
19calcium44 50 24 1110.5CAV1, PCOLCE, MYH2, MYH7, NUDT6, BGLAP

GO Terms for genes affiliated with Bone Fracture

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Cellular components related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.4MYH2, MYH7
2muscle myosin complexGO:0058599.3MYH2, MYH7
3myosin filamentGO:0329829.1MYH2, MYH7

Biological processes related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:0069369.4MYH2, MYH7
2muscle filament slidingGO:0300499.3MYH2, MYH7
3response to activityGO:0148239.2MYH2, BGLAP
4response to estrogenGO:0436278.8CAV1, BGLAP

Molecular functions related to Bone Fracture according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activator activityGO:0165049.5CAV1, PCOLCE
2microfilament motor activityGO:0001469.3MYH2, MYH7
3structural molecule activityGO:0051989.1CAV1, BGLAP
4calmodulin bindingGO:0055169.1MYH2, MYH7

Products for genes affiliated with Bone Fracture

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  • Antibodies
  • Proteins
  • Lysates

Sources for Bone Fracture

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet