MCID: BNN003
MIFTS: 46

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 14
Osteitis 12 41 69
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 41 D010000
UMLS 69 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results_in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and arthropathy. An important gene associated with Bone Inflammation Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone and bone, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 31.9 IL1B IL1RN IL6 TNF TNFSF11
2 arthropathy 31.9 ACAN COMP CRP TNF TNFSF11
3 spondyloarthropathy 1 31.4 CD40LG CRP IL17A IL1RN MMP3 MRAP
4 synovitis 31.0 COMP CRP IL1B IL1RN IL6 MMP13
5 arthritis 30.9 ACAN ADAMTS5 HLA-DRB1 IL17A IL1B IL1RN
6 osteitis fibrosa 12.4
7 condensing osteitis of the clavicle 12.2
8 paget's disease of bone 12.0
9 aseptic osteitis 12.0
10 sapho syndrome 11.8
11 paget disease of bone 3 11.4
12 renal osteodystrophy 11.2
13 mammary paget's disease 11.2
14 mccune-albright syndrome 11.1
15 pseudohypoparathyroidism, type ib 10.9
16 monostotic fibrous dysplasia 10.9
17 pustulosis of palm and sole 10.8 MRAP TNF TNFRSF1B
18 dental pulp disease 10.8 IL1B TNF TRPV1
19 tenosynovitis 10.8 CRP MRAP TNFRSF1B
20 polyposis, gastric 10.8 IL1B TNF
21 laryngitis 10.8 IL1B IL6 TNF
22 pericoronitis 10.8 CRP IL1B TNFRSF1B
23 iritis 10.8 CD40LG MRAP TNFRSF1B
24 acute vascular insufficiency of intestine 10.8 IL1B IL6 TNF
25 scorpion envenomation 10.8 IL6 TNF
26 spinal disease 10.8 CRP IL6 MRAP
27 poems syndrome 10.8 IL1B IL6 TNF
28 posterior scleritis 10.8 MRAP TNF TNFRSF10A
29 uremic pruritus 10.8 CRP IL1B IL6
30 stachybotrys chartarum 10.8 IL1B IL6 TNF
31 louse-borne relapsing fever 10.7 CRP IL6 TNF
32 rosacea 10.7 IL6 TNF TRPV1
33 periodontitis, chronic 10.7 IL1B IL6 TNFSF11
34 ischemic heart disease 10.7 CRP IL6 TNF
35 eales disease 10.7 IL1B IL6 TNF
36 diverticulitis 10.7 CRP MMP13 TNF
37 jejunoileitis 10.7 CD40LG IL1B TNF
38 mesenteric lymphadenitis 10.7 CRP IL6 MRAP
39 ocular toxoplasmosis 10.7 CD40LG IL17A TLR9
40 endometritis 10.7 IL1B IL6 TNF
41 vulvar vestibulitis syndrome 10.7 IL1B IL1RN TNF
42 actinic prurigo 10.7 HLA-DRB1 IL1B TNF
43 nose disease 10.7 TLR9 TNF TRPV1
44 lichen disease 10.7 CD40LG TLR9 TNF
45 pleural disease 10.7 CRP IL1B TNF
46 gastroschisis 10.7 IL1B IL6 MMP3
47 microscopic colitis 10.7 HLA-DRB1 IL6 TNF
48 pyuria 10.7 BCKDHA CRP MRAP
49 transverse myelitis 10.7 IL17A IL6 TNF
50 cerebral artery occlusion 10.7 IL1B IL1RN TNF

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 TLR9 IL1RN CD40LG IL6 COMP CRP
2 cellular MP:0005384 10.14 ADAMTS5 IL1RN CD40LG COMP IL6 MMP13
3 cardiovascular system MP:0005385 10.13 IL1B IL1RN CD40LG COMP IL6 CRP
4 immune system MP:0005387 10.13 ADAMTS5 IL1RN CD40LG IL6 COMP CRP
5 hematopoietic system MP:0005397 10.11 IL1B IL1RN CD40LG IL6 IL17A MMP3
6 integument MP:0010771 9.85 ADAMTS5 IL1RN CD40LG IL6 MMP13 IL1B
7 neoplasm MP:0002006 9.5 IL1B IL6 TNFSF11 TRPV1 TNF TNFRSF10A
8 skeleton MP:0005390 9.4 ADAMTS5 IL1RN CD40LG IL6 COMP MMP13

Drugs & Therapeutics for Bone Inflammation Disease

Search Clinical Trials , NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

18
Bone

MalaCards organs/tissues related to Bone Inflammation Disease:

38
Bone

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 292)
# Title Authors Year
1
Osteitis Fibrosa Cystica. ( 29415233 )
2018
2
Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism. ( 28900835 )
2017
3
Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism. ( 28554885 )
2017
4
Microarray analysis of the genes associated with osteitis in chronic rhinosinusitis. ( 27888647 )
2017
5
Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-I^ and IL-12 in BCG Osteitis Survivors R1. ( 27755461 )
2017
6
SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. ( 28250311 )
2017
7
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. ( 29276872 )
2017
8
A Case of Atypical Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) Syndrome Presenting With Osteomyelitis of the Clavicle. ( 29323824 )
2017
9
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. ( 28924111 )
2017
10
A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. ( 28765183 )
2017
11
Synovitis acne pustulosis hyperostosis osteitis (SAPHO) - paradoxical reactions and different responses to tumour necrosis factor inhibitors. ( 28977552 )
2017
12
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. ( 29386822 )
2017
13
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome - AA challenging diagnosis not to be missed. ( 27263075 )
2016
14
A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome complicated by IgA nephropathy with nephrotic syndrome. ( 28509162 )
2016
15
Impact of curative surgery on bone in a patient with osteitis fibrosa cystica of primary hyperparathyroidism. ( 27030464 )
2016
16
A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, and Osteitis Fibrosa Cystica. ( 26881146 )
2016
17
Challenges in Treating Secondary Syphilis Osteitis in an Immunocompromised Patient with a Penicillin Allergy: Case Report and Review of the Literature. ( 27313920 )
2016
18
Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. ( 27742022 )
2016
19
Osteitis fibrosa cystica. ( 27238197 )
2016
20
Effect of a treat-to-target strategy based on methotrexate and intra-articular betamethasone with or without additional cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis: results from a 2-year randomized double-blind placebo-controlled trial (CIMESTRA). ( 27775461 )
2016
21
Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. ( 26917545 )
2016
22
Gingival pustules and sterile diffuse sclerosing osteomyelitis as a feature of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. ( 26619759 )
2016
23
Interleukin-10 gene promoter region polymorphisms are not associated with BCG osteitis in vaccinated infants. ( 26459526 )
2015
24
Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-GuAcrin osteitis following newborn vaccination. ( 25605403 )
2015
25
Osteitis fibrosa cystica in primary hyperparathyroidism. ( 26261355 )
2015
26
Conditional TNF-I+ Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis. ( 26503912 )
2015
27
Tuberculosis of wrist joint in an 8-year-old child presenting as hamate osteitis: A rare case report. ( 26566348 )
2015
28
Unusual presentations and pitfalls of secondary syphilis: osteitis, pneumonia and malignancy. ( 26504092 )
2015
29
Brown tumors: severe osteitis fibrosa cystica. ( 25939949 )
2015
30
A new case of Mycoplasma hominis mediastinitis and sternal osteitis after cardiac surgery. ( 25532483 )
2015
31
An Unusual Bone Metastasis Mimicking SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) Syndrome on Bone Scintigraphy. ( 26505860 )
2015
32
Osteitis fibrosa cystica in a domestic young cat. ( 28491388 )
2015
33
A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with hypertrophic pachymeningitis. ( 25549534 )
2015
34
Synovitis and osteitis in the left sternoclavicular joint in a 60-year-old woman. ( 26578503 )
2015
35
Occurrence of a granulomatous mastitis and aseptic osteitis after anti-TNF therapy in a patient with pustular psoriasis. ( 26054447 )
2015
36
Tumor suppressor gene mutation in a patient with a history of hyperparathyroidism-jaw tumor syndrome and healed generalized osteitis fibrosa cystica: a case report and genetic pathophysiology review. ( 25511968 )
2015
37
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. ( 25828738 )
2015
38
Differing roles for TGF-I^/Smad signaling in osteitis in chronic rhinosinusitis with and without nasal polyps. ( 26265084 )
2015
39
Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. ( 24533553 )
2014
40
Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome in Childhood; A Rare Clinical Entity. ( 25793079 )
2014
41
A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial. ( 24412895 )
2014
42
Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitis without nasal polyps. ( 24717943 )
2014
43
Steroid-independent upregulation of matrix metalloproteinase 9 in chronic rhinosinusitis patients with radiographic evidence of osteitis. ( 23401274 )
2013
44
Polyostotic osteitis in secondary syphilis in an HIV-infected patient. ( 23859912 )
2013
45
Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial. ( 22915624 )
2013
46
Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. ( 23397374 )
2013
47
Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy. ( 23365170 )
2013
48
SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis): a multidisciplinary approach. ( 24237723 )
2013
49
Variant MBL2 genotypes producing low mannose-binding lectin may increase risk of Bacillus Calmette-Guerin osteitis in vaccinated newborns. ( 23865867 )
2013
50
Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: report of 2 cases. ( 22441965 )
2013

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CD40LG CRP HLA-DRB1 IL17A IL1B IL1RN
2
Show member pathways
13.42 CD40LG IL17A IL1B IL6 TLR9 TNF
3
Show member pathways
13.35 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
4
Show member pathways
13.32 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
5
Show member pathways
12.88 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
6
Show member pathways
12.82 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
7
Show member pathways
12.75 ACAN ADAMTS5 COMP MMP13 MMP3
8
Show member pathways
12.72 CD40LG IL1B IL6 TLR9 TNF TNFRSF1B
9
Show member pathways
12.63 CD40LG IL1B TLR9 TNF TNFRSF10A TNFRSF1B
10
Show member pathways
12.61 HLA-DRB1 IL17A IL1B IL6 TNF
11
Show member pathways
12.46 CD40LG IL17A IL1B IL6 TNF
12
Show member pathways
12.33 CRP IL1B IL6 TNF
13
Show member pathways
12.3 IL17A IL1B IL6 MMP13 MMP3 TNF
14 12.27 CD40LG IL17A IL1B IL1RN TLR9 TNF
15
Show member pathways
12.26 CD40LG HLA-DRB1 IL1B TNF
16 12.26 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
17 12.24 HLA-DRB1 IL1B IL6 TLR9 TNF
18
Show member pathways
12.2 IL1B IL6 TLR9 TNF
19 12.19 IL1B IL1RN IL6 TNF
20
Show member pathways
12.18 IL17A IL1B IL6 TNF
21 12.05 ACAN IL1B IL6 TNF
22 11.98 IL1B IL6 MMP3 TNF TNFRSF1B
23
Show member pathways
11.94 IL17A IL1B IL6 TLR9 TNF
24 11.93 HLA-DRB1 IL1B IL6 TNF
25 11.92 CD40LG IL1B TNF TNFSF11
26
Show member pathways
11.89 IL17A IL1B IL6 TLR9
27
Show member pathways
11.82 CRP IL6 TNFSF11
28 11.79 IL17A IL1B IL6 MMP3 TNF TNFRSF1B
29 11.78 IL17A IL1B TNF
30 11.78 IL1B IL6 TLR9 TNF
31
Show member pathways
11.77 CD40LG TNF TNFRSF1B TNFSF11
32 11.76 IL1B IL6 TNF
33
Show member pathways
11.72 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
34 11.7 CD40LG IL6 TLR9 TNF
35 11.68 ACAN ADAMTS5 MMP13
36 11.67 IL1B IL6 TNF
37 11.6 IL1B IL6 TNF
38
Show member pathways
11.57 CD40LG IL1B IL6 MMP3 TNF
39 11.52 IL1B IL6 TNF TNFSF11
40 11.41 IL1B IL1RN IL6 TNF TNFRSF1B
41 11.39 IL1B IL6 TNF
42 11.36 IL1B IL6 TLR9 TNF
43 11.33 IL1B IL6 TNF
44 11.28 IL17A IL1B IL6 TNF
45 11.23 HLA-DRB1 IL1B IL6 TNF
46 11.14 CD40LG IL17A IL1B IL6 TNF TNFSF11
47 11.12 CD40LG COMP IL1B IL6 TLR9 TNF
48 11.12 HLA-DRB1 IL17A IL1B IL6 MMP3 TNF
49 11.07 CRP IL6 TNF
50 11.02 ACAN CD40LG IL17A IL1B IL6 TNF

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ACAN ADAMTS5 CD40LG COMP CRP IL17A
2 external side of plasma membrane GO:0009897 9.65 CD40LG HLA-DRB1 IL17A TNF TRPV1
3 proteinaceous extracellular matrix GO:0005578 9.63 ACAN ADAMTS5 COMP MMP13 MMP3 TLR9
4 extracellular space GO:0005615 9.47 ACAN ADAMTS5 CD40LG COMP CRP IL17A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1B TLR9 TNF TNFSF11
2 regulation of receptor activity GO:0010469 9.87 CD40LG IL17A IL1B IL1RN IL6 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF TNFSF11
4 response to glucocorticoid GO:0051384 9.82 IL1RN IL6 TNF
5 positive regulation of T cell proliferation GO:0042102 9.81 CD40LG IL1B IL6
6 extracellular matrix disassembly GO:0022617 9.8 ACAN ADAMTS5 MMP13 MMP3
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
8 positive regulation of JNK cascade GO:0046330 9.78 IL1B TLR9 TNF TNFSF11
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B TNF TRPV1
10 extrinsic apoptotic signaling pathway GO:0097191 9.77 TNF TNFRSF10A TNFRSF1B
11 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 TLR9 TNF
12 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR9 TNF
13 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR9 TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.7 IL17A TNF TNFSF11
15 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR9 TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
17 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.65 IL1B TLR9
18 immune response GO:0006955 9.65 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
19 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
21 growth plate cartilage development GO:0003417 9.63 COMP MMP13
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF TNFRSF1B
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 CD40LG IL1B IL6 TLR9 TNF TNFSF11
24 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
25 regulation of immunoglobulin secretion GO:0051023 9.61 CD40LG TNF
26 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
27 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 IL1RN IL6
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
29 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
30 fever generation GO:0001660 9.43 IL1B IL1RN TRPV1
31 inflammatory response GO:0006954 9.36 CD40LG CRP IL17A IL1B IL1RN IL6
32 positive regulation of gene expression GO:0010628 10.02 CRP IL1B IL6 TLR9 TNF

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF11
2 cytokine activity GO:0005125 9.17 CD40LG IL17A IL1B IL1RN IL6 TNF
3 interleukin-1 receptor binding GO:0005149 9.13 IL1B IL1RN TLR9

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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