MCID: BNN003
MIFTS: 45

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 14
Osteitis 12 42 69
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 42 D010000
UMLS 69 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results_in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to condensing osteitis of the clavicle and osteitis fibrosa. An important gene associated with Bone Inflammation Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Benzocaine and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
id Related Disease Score Top Affiliating Genes
1 condensing osteitis of the clavicle 12.1
2 osteitis fibrosa 12.1
3 aseptic osteitis 11.9
4 sapho syndrome 11.7
5 paget's disease of bone 11.6
6 renal osteodystrophy 11.1
7 dermatosis papulosa nigra 11.1 MRAP TNF TNFRSF1B
8 epulis 11.1 IL1B TNF TRPV1
9 scrotal carcinoma 11.1 IL1B IL6 TNF
10 smarca4-deficient sarcoma of thorax 11.1 IL6 TNF
11 upper gum cancer 11.1 IL1B IL6 TNF
12 pulmonary plasma cell granuloma 11.1 CRP IL1B TNFRSF1B
13 plasmodium falciparum malaria 11.1 CD40LG MRAP TNFRSF1B
14 bipolar i disorder 11.1 IL1B IL6 TNF
15 erythema elevatum diutinum 11.1 CRP IL6 MRAP
16 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 11.1 IL1B IL6 TNF
17 x-linked dominant intellectual disability-epilepsy syndrome 11.1 CRP IL1B IL6
18 prostate calculus 11.1 MRAP TNF TNFRSF10A
19 cicatricial lagophthalmos 11.1 CRP IL6 TNF
20 pityriasis rosea 11.1 IL6 TNF TRPV1
21 islet cell tumor 11.1 CRP IL6 TNF
22 early-onset zonular cataract 11.1 IL1B IL6 TNF
23 cryptogenic organizing pneumonia 11.1 CRP IL17A TRPV1
24 petrous apex meningioma 11.1 CRP MMP13 TNF
25 ileocolitis 11.1 CD40LG IL1B TNF
26 queensland tick typhus 11.1 CRP IL6 MRAP
27 placental abruption 11.1 CRP IL6 TNF
28 arthus reaction 11.1 CRP IL1B TNF
29 ampulla of vater neoplasm 11.1 IL1B IL6 TNF
30 anencephaly and spina bifida x-linked 11.1 HLA-DRB1 IL6 TNF
31 moved to 244450 11.1 HLA-DRB1 IL1B TNF
32 supranuclear ocular palsy 11.1 MMP1 MMP3
33 oculo-cerebral dysplasia 11.1 CD40LG IL17A TLR9
34 dermatomycosis 11.1 CD40LG CRP TNF
35 walker dyson syndrome 11.1 IL1B IL1RN TNF
36 familial mediterranean fever, ad 11.1 CRP IL1B TNF
37 acute vascular insufficiency of intestine 11.1 CD40LG TLR9 TNF
38 scoliosis, arachnodactyly, and blindness 11.1 IL1B IL6 MMP3
39 dehydration polycythemia 11.1 TLR9 TNF TRPV1
40 tricho onychic dysplasia 11.1 IL17A IL6 TNF
41 pulmonary hypertension 11.1 IL1B MMP1 TNF
42 lymphocytic colitis 11.1 HLA-DRB1 IL6 TNF
43 hypogonadotropism 11.1 CD40LG IL6 TNF
44 functional gastric disease 11.1 CD40LG CRP TNF
45 capillary leak syndrome 11.1 BCKDHA CRP MRAP
46 crystal arthropathies 11.1 CRP IL1RN IL6
47 neuronal ceroid-lipofuscinoses 11.1 COMP CRP MRAP
48 ariboflavinosis 11.1 CD40LG CRP IL6
49 ovarian mucinous adenofibroma 11.1 IL1B IL6 TNF
50 shoulder impingement syndrome 11.1 CRP IL1RN IL6

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 TNF TNFRSF10A TNFRSF1B TNFSF11 TRPV1 CD40LG
2 immune system MP:0005387 10.13 CD40LG COMP CRP IL17A IL1B IL1RN
3 hematopoietic system MP:0005397 10.11 TLR9 TNF TNFRSF10A TNFRSF1B TNFSF11 CD40LG
4 cardiovascular system MP:0005385 10.1 CD40LG COMP CRP IL1B IL1RN IL6
5 integument MP:0010771 9.81 MMP13 TNF CD40LG IL1B IL1RN IL6
6 neoplasm MP:0002006 9.56 IL1B IL6 MMP1 TNF TNFRSF10A TNFRSF1B
7 skeleton MP:0005390 9.36 CD40LG COMP IL17A IL1B IL1RN IL6

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Menthol Approved Phase 4 2216-51-5 16666
3
Zoledronic acid Approved Phase 4,Phase 3,Phase 2 118072-93-8 68740
4
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 9552079 2713
5
Alendronate Approved Phase 4,Phase 3 121268-17-5, 66376-36-1 2088
6
Pamidronate Approved Phase 4,Phase 2,Phase 1 40391-99-9 4674
7
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
8
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
9
Pioglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 111025-46-8 4829
10
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
11
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
12 sodium fluoride Approved Phase 4 7681-49-4
13
Thymol Approved Phase 4 89-83-8 6989
14
Zinc Approved Phase 4,Phase 1,Phase 2 7440-66-6 32051 23994
15
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
16
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 1 104987-11-3 445643 439492
17
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
18
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
21
Coal tar Approved Phase 4 8007-45-2
22
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
23
Metronidazole Approved Phase 4 443-48-1 4173
24
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
25
Iron Approved Phase 4,Phase 2 7439-89-6 23925
26
Sulfasalazine Approved Phase 4 599-79-1 5353980 5359476
27
Denosumab Approved Phase 4,Phase 1,Phase 2 615258-40-7
28
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
29
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
30
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
31
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
32
Calcium acetate Approved Phase 4 62-54-4
33
Sevelamer Approved Phase 4 52757-95-6, 152751-57-0 3085017
34
Acetaminophen Approved Phase 4 103-90-2 1983
35
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
36
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
37
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 67-97-0 6221 10883523 5280795
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-14-6 5280793
39 tannic acid Approved, Nutraceutical Phase 4
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1406-16-2
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
43 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Calcium, Dietary Phase 4,Phase 3,Phase 2
49 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
50 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 381)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
2 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
3 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4 Vitamin D3
4 Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB) Completed NCT00774020 Phase 4 Zoledronic acid
5 Re-treatment of Patients With Paget's Disease Using Zoledronic Acid Completed NCT00740129 Phase 4 Zoledronic Acid
6 Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast® Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
7 Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
8 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
9 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4 Adalimumab;Placebo
10 Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions Completed NCT01016184 Phase 4
11 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
12 Effect of Paricalcitol on Markers of Inflammation in Hemodialysis Patients Completed NCT00294866 Phase 4 Paricalcitol
13 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)
14 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
15 Predictors of the Response to Adalimumab in Rheumatoid Arthritis Completed NCT00234234 Phase 4 Adalimumab
16 Effects of Vitamin D Supplementation in Obesity Completed NCT01037140 Phase 4 Cholecalciferol;placebo
17 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
18 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Intravenous infusion of Dexmedetomidine or 0.9% Saline
19 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
20 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
21 Regenerative Surgical Treatment of Peri-implantitis Completed NCT02500654 Phase 4
22 How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months? Completed NCT01437696 Phase 4
23 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
24 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
25 High Dosage Vitamin D and Osteoporosis Completed NCT00491920 Phase 4 cholecalciferol (Vitamin D3);placebo
26 The Effects of Omega-3 Fatty Acids in Renal Transplantation Completed NCT01744067 Phase 4 Omega-3 fatty acids;Placebo
27 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
28 Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure Recruiting NCT02981017 Phase 4
29 Treatment of Periodontitis in Obese Individuals Recruiting NCT03103204 Phase 4
30 Impact of Oral Hygiene Gels on Peri-implant Mucositis Recruiting NCT03243591 Phase 4
31 Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics Recruiting NCT02185209 Phase 4 Placebo;Amoxicillin Sandoz;Metronidazole Sanofi;Phenoxymethylpenicillin Meda
32 Paricalcitol Improves Anemia of Inflammation Recruiting NCT02876211 Phase 4 Paricalcitol;Epoetin beta;Placebo
33 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Recruiting NCT02634541 Phase 4 Adalimumab
34 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA) Active, not recruiting NCT02198651 Phase 4 Adalimumab
35 Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen Active, not recruiting NCT02577042 Phase 4 Raltegravir;PI-based regimen;Atorvastatin
36 Treatment of Peri-implantitis Lesions by Using Biomaterial Active, not recruiting NCT02375750 Phase 4
37 Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World" Enrolling by invitation NCT02878161 Phase 4 methotrexate(necessary);leflunomide (permitted, not necessary);NSAIDs (permitted,not necessary);Glucocorticoids (permitted,not necessary)
38 Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease Not yet recruiting NCT02792413 Phase 4 Denosumab;NaCl (placebo)
39 Bone Health in Aging HIV Infected Women Not yet recruiting NCT02815566 Phase 4 tenofovir-alafenamide-emtricitabine;tenofovir-emtricitabine
40 Discontinuation of TNF-alpha Inhibitors in Patients With Spondyloarthritis Terminated NCT00726804 Phase 4 Discontinuation of TNF-alpha inhibitor and re-starting it if flare-up in disease activity (etanercept or adalimumab)
41 Paricalcitol on Albuminuria, Inflammation and Fibrosis on Proteinuric Chronic Renal Diseases (PALIFE Study) Terminated NCT01820078 Phase 4 Experimental arm
42 Effect of Phosphate Binders on Markers of Vascular Health in Chronic Kidney Disease Stages 3 and 4 Terminated NCT01277497 Phase 4 Sevelamer carbonate;Calcium acetate
43 Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium Terminated NCT01806974 Phase 4
44 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4 Tramadol /acetaminophen;Diclofenac
45 Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA) Terminated NCT00796705 Phase 4 Adalimumab;Adalimumab placebo;Etanercept
46 Sustainability of Vitamin D Levels After Repletion With Ergocalciferol In Chronic Kidney Disease Stage 5D Terminated NCT01312441 Phase 4 Ergocalciferol;Placebo
47 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
48 Human Tumor Necrosis Factor Alpha (TNFa)-Induced Pre-B Cell Bone Marrow Emigrants Withdrawn NCT01009879 Phase 4 Etanercept
49 Effectiveness and Safety of Spondylitis Related to Inflammatory Bowel Disease Withdrawn NCT00972218 Phase 4
50 Effect on Liver Histology of Vitamin D in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01623024 Phase 3 Vitamin D

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

MalaCards organs/tissues related to Bone Inflammation Disease:

39
Bone, Kidney, Bone Marrow, Liver, Eye, Endothelial, Monocytes

Publications for Bone Inflammation Disease

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD40LG CRP HLA-DRB1 IL17A IL1B IL1RN
2
Show member pathways
13.41 CD40LG IL17A IL1B IL6 TLR9 TNF
3
Show member pathways
13.33 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
4
Show member pathways
13.28 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
5
Show member pathways
12.88 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
6
Show member pathways
12.82 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
7
Show member pathways
12.75 ACAN COMP MMP1 MMP13 MMP3
8
Show member pathways
12.71 CD40LG IL1B IL6 TLR9 TNF TNFRSF1B
9
Show member pathways
12.63 CD40LG IL1B TLR9 TNF TNFRSF10A TNFRSF1B
10
Show member pathways
12.61 HLA-DRB1 IL17A IL1B IL6 TNF
11
Show member pathways
12.46 CD40LG IL17A IL1B IL6 TNF
12 12.42 CD40LG IL17A IL1B IL1RN TLR9 TNF
13
Show member pathways
12.27 CD40LG HLA-DRB1 IL1B TNF
14 12.26 CD40LG TNFRSF10A TNFRSF1B TNFSF11
15
Show member pathways
12.24 IL17A IL1B IL6 MMP1 MMP13 MMP3
16 12.23 HLA-DRB1 IL1B IL6 TLR9 TNF
17
Show member pathways
12.21 IL1B IL6 TLR9 TNF
18 12.2 IL6 MMP1 TLR9 TNF
19 12.2 IL1B IL1RN IL6 TNF
20
Show member pathways
12.18 IL17A IL1B IL6 TNF
21 12.04 ACAN IL1B IL6 TNF
22 11.98 IL1B IL6 MMP3 TNF TNFRSF1B
23
Show member pathways
11.96 IL17A IL1B IL6 TLR9 TNF
24
Show member pathways
11.93 MMP1 MMP13 MMP3 TNF
25
Show member pathways
11.93 IL17A IL1B IL6 TLR9
26 11.92 HLA-DRB1 IL1B IL6 TNF
27 11.91 CD40LG IL1B TNF TNFSF11
28
Show member pathways
11.82 CRP IL6 TNFSF11
29 11.79 IL17A IL1B TNF
30 11.78 IL1B IL6 TLR9 TNF
31
Show member pathways
11.78 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
32 11.76 IL1B IL6 TNF
33
Show member pathways
11.76 CD40LG TNF TNFRSF1B TNFSF11
34 11.76 IL17A IL1B IL6 MMP1 MMP3 TNF
35 11.72 CD40LG IL6 TLR9 TNF
36 11.68 IL1B IL6 TNF
37 11.66 MMP1 MMP13 MMP3
38 11.61 IL1B IL6 TNF
39
Show member pathways
11.53 CD40LG IL1B IL6 MMP1 MMP3 TNF
40 11.52 IL1B IL6 TNF TNFSF11
41 11.49 IL1B IL1RN IL6 TNF TNFRSF1B
42 11.44 ACAN MMP1 MMP3
43 11.39 IL1B IL6 TNF
44 11.37 IL1B IL6 TLR9 TNF
45 11.32 IL1B IL6 TNF
46 11.32 IL17A IL1B IL6 TNF
47 11.27 HLA-DRB1 IL1B IL6 TNF
48 11.18 CD40LG IL17A IL1B IL6 TNF TNFSF11
49 11.18 HLA-DRB1 IL17A IL1B IL6 MMP1 MMP3
50 11.12 CD40LG COMP IL1B IL6 TLR9 TNF

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 ACAN CD40LG COMP CRP IL17A IL1B
2 proteinaceous extracellular matrix GO:0005578 9.73 ACAN COMP MMP1 MMP13 MMP3 TLR9
3 extracellular matrix GO:0031012 9.72 ACAN COMP MMP1 MMP13 MMP3
4 external side of plasma membrane GO:0009897 9.63 CD40LG HLA-DRB1 IL17A IL6 TNF TRPV1
5 extracellular region GO:0005576 9.5 ACAN CD40LG COMP CRP IL17A IL1B

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 37)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.97 IL6 TNF TNFRSF10A TNFRSF1B
2 leukocyte migration GO:0050900 9.96 IL1B MMP1 TNF TNFRSF10A
3 response to lipopolysaccharide GO:0032496 9.94 IL1B IL6 TNFRSF10A TNFRSF1B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 IL1B TLR9 TNF TNFSF11
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF TNFSF11
6 response to glucocorticoid GO:0051384 9.83 IL1RN IL6 TNF
7 collagen catabolic process GO:0030574 9.82 MMP1 MMP13 MMP3
8 positive regulation of T cell proliferation GO:0042102 9.82 CD40LG IL1B IL6
9 extracellular matrix disassembly GO:0022617 9.81 ACAN MMP1 MMP13 MMP3
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
11 positive regulation of JNK cascade GO:0046330 9.78 IL1B TLR9 TNF TNFSF11
12 extrinsic apoptotic signaling pathway GO:0097191 9.77 TNF TNFRSF10A TNFRSF1B
13 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 TLR9 TNF
14 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR9 TNF
15 positive regulation of NF-kappaB import into nucleus GO:0042346 9.71 IL1B TLR9 TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.7 IL17A TNF TNFSF11
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
18 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 IL1B TLR9
19 positive regulation of chemokine production GO:0032722 9.67 IL6 TLR9 TNF
20 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
21 immune response GO:0006955 9.65 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
22 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
23 growth plate cartilage development GO:0003417 9.63 COMP MMP13
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF TNFRSF1B
25 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 CD40LG IL1B IL6 TLR9 TNF TNFSF11
26 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.62 IL6 TNF
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B IL6 TNF TRPV1
28 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
29 regulation of immunoglobulin secretion GO:0051023 9.6 CD40LG TNF
30 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
31 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 IL1RN IL6
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
34 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.36 IL6
35 inflammatory response GO:0006954 9.36 CD40LG CRP IL17A IL1B IL1RN IL6
36 fever generation GO:0001660 9.26 IL1B TRPV1
37 positive regulation of gene expression GO:0010628 10.02 CRP IL1B IL6 TLR9 TNF

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF11
2 cytokine activity GO:0005125 9.17 CD40LG IL17A IL1B IL1RN IL6 TNF
3 interleukin-1 receptor binding GO:0005149 9.13 IL1B IL1RN TLR9

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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