MCID: BNN003
MIFTS: 44

Bone Inflammation Disease malady

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

Aliases & Descriptions for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 14
Osteitis 12 42 14 69
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 42 D010000
UMLS 69 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results_in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to condensing osteitis of the clavicle and osteitis fibrosa. An important gene associated with Bone Inflammation Disease is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Benzocaine and Cortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone and bone, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
id Related Disease Score Top Affiliating Genes
1 condensing osteitis of the clavicle 12.1
2 osteitis fibrosa 12.1
3 aseptic osteitis 11.9
4 sapho syndrome 11.7
5 paget's disease of bone 11.6
6 renal osteodystrophy 11.1
7 mammary paget's disease 11.1
8 mccune-albright syndrome, somatic, mosaic 11.0
9 paget disease of bone 3 10.9
10 pseudohypoparathyroidism, type ib 10.8
11 monostotic fibrous dysplasia 10.8
12 spondyloarthropathy 1 10.6
13 caffey disease 10.6
14 arthritis 10.6
15 osteomyelitis 10.6
16 epicondylitis 10.6
17 arthropathy 10.6
18 osgood-schlatter's disease 10.6
19 intussusception 10.5 IL1B TNF
20 occupational dermatitis 10.5 MRAP TNF TNFRSF1B
21 bladder calculus 10.5 MRAP TNF TNFRSF1B
22 nephronophthisis 1, juvenile 10.5 MRAP TNF TNFRSF1B
23 unilateral multicystic dysplastic kidney 10.5 CRP IL6 TNF
24 cataract 10.5 CRP IL1B TNF
25 anal paget's disease 10.5 IL1B IL6 TNF
26 bipolar i disorder 10.5 IL1B IL6 TNF
27 cardiac tuberculosis 10.5 CRP IL6 MRAP
28 tinea capitis 10.5 IL1B IL6 TNF
29 laryngotracheoesophageal cleft type 2 10.5 CRP IL1B IL6
30 cerebrum cancer 10.5 CRP IL1B TNFRSF1B
31 measles 10.5 IL1B IL6 TNF
32 prostate calculus 10.5 MRAP TNF TNFRSF10A
33 primary lacrimal atrophy 10.4 CD40LG MRAP TNFRSF1B
34 hypoparathyroidism-retardation-dysmorphism syndrome 10.4 IL1B IL6 TNF
35 steroid dehydrogenase deficiency dental anomalies 10.4 IL1B IL6 TNF
36 joint disorders 10.4 CRP IL6 TNF
37 central epithelioid sarcoma 10.4 CRP MMP13 TNF
38 nemaline myopathy 1, autosomal dominant or recessive 10.4 IL1RN TNF TNFRSF1B
39 mikulicz disease 10.4 IL1B IL6 TNF
40 parkinson disease 11 10.4 IL17A IL1B TNF
41 cicatricial lagophthalmos 10.4 CRP IL6 TNF
42 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.4 HLA-DRB1 IL6 TNF
43 gastroduodenal crohn's disease 10.4 CD40LG IL1B TNF
44 fallopian tube adenomatoid tumor 10.4 CRP IL1RN MRAP
45 warthin tumor 10.4 IL1B IL1RN TNF
46 pyloric stenosis, infantile hypertrophic, 2 10.4 CRP IL1B TNF
47 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.4 IL1B IL6 TNF
48 ectodermal dysplasia bartalos type 10.4 IL1B IL6 TNF
49 gastric lymphoma 10.4 CRP IL17A IL6
50 dermatomycosis 10.4 CD40LG CRP TNF

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 MMP1 MMP13 MMP3 TNF TNFRSF10A TNFRSF1B
2 immune system MP:0005387 10.1 ADAMTS5 CD40LG COMP CRP IL17A IL1B
3 integument MP:0010771 9.85 ADAMTS5 CD40LG IL1B IL1RN IL6 MMP13
4 neoplasm MP:0002006 9.5 IL1B IL6 MMP1 TNF TNFRSF10A TNFRSF1B
5 skeleton MP:0005390 9.4 ADAMTS5 CD40LG COMP IL17A IL1B IL1RN

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 502)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
2
Cortisone acetate Approved Phase 4 1950-04-4, 50-04-4 5745
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
4
Hydrocortisone Approved, Vet_approved Phase 4,Early Phase 1 50-23-7 5754 657311
5
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 134678-17-4 60825
6
Lopinavir Approved Phase 4 192725-17-0 92727
7
Nevirapine Approved Phase 4 129618-40-2 4463
8
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
9
Zidovudine Approved Phase 4,Phase 2,Phase 3 30516-87-1 35370
10
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
11
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
12
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
13
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2 55-56-1 9552079 2713
14
Zoledronic acid Approved Phase 4,Phase 3 118072-93-8 68740
15
Alendronate Approved Phase 4,Phase 3,Phase 2 121268-17-5, 66376-36-1 2088
16
Pamidronate Approved Phase 4,Phase 2,Phase 1 40391-99-9 4674
17
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
18
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
19
Pioglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 111025-46-8 4829
20
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
21
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
22 sodium fluoride Approved Phase 4 7681-49-4
23
Thymol Approved Phase 4 89-83-8 6989
24
Zinc Approved Phase 4 7440-66-6 32051 23994
25
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 1 104987-11-3 445643 439492
26
Aceclofenac Approved Phase 4 89796-99-6
27
Acetaminophen Approved Phase 4 103-90-2 1983
28
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
29
Drospirenone Approved Phase 4 67392-87-4 68873
30
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
31
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
32
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
33
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
34
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
35
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
36
Amoxicillin Approved, Vet_approved Phase 4,Phase 1,Phase 2 26787-78-0 33613 2171
37
Iron Approved Phase 4,Phase 2,Early Phase 1 7439-89-6 23925
38
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
39
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
40
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
41
Sevelamer Approved Phase 4,Phase 2,Phase 1 52757-95-6, 152751-57-0 3085017
42
Salmon Calcitonin Approved, Investigational Phase 4,Phase 3 47931-85-1 16129616
43
Daptomycin Approved, Investigational Phase 4,Phase 3 103060-53-3 16129629
44
Vancomycin Approved Phase 4,Phase 3,Early Phase 1 1404-90-6 441141 14969
45
Coal tar Approved Phase 4 8007-45-2
46
Metronidazole Approved Phase 4 443-48-1 4173
47
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
48
Sulfasalazine Approved Phase 4 599-79-1 5353980 5359476
49
Liraglutide Approved Phase 4,Phase 2 204656-20-2
50
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054

Interventional clinical trials:

(show top 50) (show all 577)
id Name Status NCT ID Phase
1 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4
2 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
3 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4
4 Effect of Doxium on High Sensitivity CRP and Endothelin-1 Serum Levels in Patients With Diabetic Retinopathy Unknown status NCT01382498 Phase 4
5 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Unknown status NCT02277587 Phase 4
6 Investigation of Sacroiliac Fusion Treatment (INSITE) Unknown status NCT01681004 Phase 4
7 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
8 MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS) Unknown status NCT00122226 Phase 4
9 Efficacy of 0.2 % Digluconate Chlorhexidine Mouthwash for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4
10 Efficacy and Safety of Single Dose of 5 mg Zoledronic Acid in Chinese Patients With Paget's Disease of Bone (PDB) Completed NCT00774020 Phase 4
11 Re-treatment of Patients With Paget's Disease Using Zoledronic Acid Completed NCT00740129 Phase 4
12 Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast® Completed NCT00668200 Phase 4
13 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4
14 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4
15 Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions Completed NCT01016184 Phase 4
16 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4
17 Effect of Paricalcitol on Markers of Inflammation in Hemodialysis Patients Completed NCT00294866 Phase 4
18 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4
19 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
20 Predictors of the Response to Adalimumab in Rheumatoid Arthritis Completed NCT00234234 Phase 4
21 Effects of Vitamin D Supplementation in Obesity Completed NCT01037140 Phase 4
22 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4
23 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4
24 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
25 Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02734784 Phase 4
26 Regenerative Surgical Treatment of Peri-implantitis Completed NCT02500654 Phase 4
27 How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months? Completed NCT01437696 Phase 4
28 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4
29 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
30 High Dosage Vitamin D and Osteoporosis Completed NCT00491920 Phase 4
31 The Effects of Omega-3 Fatty Acids in Renal Transplantation Completed NCT01744067 Phase 4
32 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
33 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4
34 The Link Between Obesity And Vitamin D in Bariatric Patients With Omega-loop Bypass Surgery Completed NCT02092376 Phase 4
35 Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus Completed NCT00668330 Phase 4
36 Vitamin D Supplementation for the Prevention of Cardiovascular Risk Completed NCT02020694 Phase 4
37 Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study Completed NCT00640224 Phase 4
38 Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients Completed NCT00346697 Phase 4
39 Effect of Vitamin D Supplementation on Muscle Mass and Function Completed NCT01199926 Phase 4
40 Effect of Vitamin D Supplementation on Muscular Strength, Musculoskeletal Pain and Headache Completed NCT01263288 Phase 4
41 Can Vitamin D Supplementation Prevent Type 2 Diabetes? Completed NCT02112721 Phase 4
42 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
43 A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation Completed NCT00067730 Phase 4
44 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4
45 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4
46 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4
47 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA) Recruiting NCT02198651 Phase 4
48 Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure Recruiting NCT02981017 Phase 4
49 Treatment of Periodontitis in Obese Individuals Recruiting NCT03103204 Phase 4
50 Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics Recruiting NCT02185209 Phase 4

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

MalaCards organs/tissues related to Bone Inflammation Disease:

39
Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

18
Bone

Publications for Bone Inflammation Disease

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD40LG CRP HLA-DRB1 IL17A IL1B IL1RN
2
Show member pathways
13.41 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
3
Show member pathways
13.29 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
4
Show member pathways
13.25 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
5
Show member pathways
12.85 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
6
Show member pathways
12.8 HLA-DRB1 IL1B IL6 TNF TNFRSF10A
7
Show member pathways
12.73 ACAN ADAMTS5 COMP MMP1 MMP13 MMP3
8
Show member pathways
12.7 CD40LG IL1B IL6 TNF TNFRSF1B
9
Show member pathways
12.6 CD40LG IL1B TNF TNFRSF10A TNFRSF1B TNFSF11
10
Show member pathways
12.59 HLA-DRB1 IL17A IL1B IL6 TNF
11 12.47 CD40LG IL17A IL1B IL1RN TNF TNFRSF1B
12
Show member pathways
12.42 CD40LG IL17A IL1B IL6 TNF
13
Show member pathways
12.33 CRP IL1B IL6 TNF
14
Show member pathways
12.26 MMP1 MMP13 MMP3 TNFSF11
15
Show member pathways
12.25 CD40LG HLA-DRB1 IL1B TNF
16 12.24 CD40LG TNFRSF10A TNFRSF1B TNFSF11
17 12.22 HLA-DRB1 IL1B IL6 TNF
18 12.17 IL1B IL1RN IL6 TNF
19
Show member pathways
12.16 IL17A IL1B IL6 TNF
20
Show member pathways
12.13 IL17A IL1B IL6 MMP1 MMP13 MMP3
21 12.01 ACAN IL1B IL6 TNF
22 11.96 IL1B IL6 MMP3 TNF TNFRSF1B
23
Show member pathways
11.94 IL17A IL1B IL6 TNF
24
Show member pathways
11.88 MMP1 MMP13 MMP3 TNF
25 11.86 HLA-DRB1 IL1B IL6 TNF
26 11.85 CD40LG IL1B TNF TNFSF11
27
Show member pathways
11.82 CRP IL6 TNFSF11
28
Show member pathways
11.8 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
29 11.78 IL17A IL1B TNF
30 11.76 IL1B IL6 TNF
31 11.75 IL1B IL6 TNF
32 11.71 CD40LG IL6 TNF
33
Show member pathways
11.71 CD40LG TNF TNFRSF1B TNFSF11
34 11.68 ACAN ADAMTS5 MMP13
35 11.66 IL1B IL6 TNF
36 11.64 MMP1 MMP13 MMP3
37 11.58 IL1B IL6 TNF
38 11.56 IL17A IL1B IL6 MMP1 MMP3 TNF
39 11.49 IL1B IL6 TNF TNFSF11
40 11.46 IL1B IL1RN IL6 TNF TNFRSF1B
41
Show member pathways
11.43 CD40LG IL1B IL6 MMP1 MMP3 TNF
42 11.42 ACAN MMP1 MMP3
43 11.41 CD40LG COMP IL1B IL6 TNF
44 11.36 IL1B IL6 TNF
45 11.36 IL1B IL6 TNF
46 11.32 IL17A IL1B IL6 TNF
47 11.28 IL1B IL6 TNF
48 11.27 HLA-DRB1 IL1B IL6 TNF
49 11.18 HLA-DRB1 IL17A IL1B IL6 MMP1 MMP3
50 11.16 CD40LG IL17A IL1B IL6 TNF TNFSF11

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 ACAN ADAMTS5 CD40LG COMP CRP IL17A
2 proteinaceous extracellular matrix GO:0005578 9.73 ACAN ADAMTS5 COMP MMP1 MMP13 MMP3
3 external side of plasma membrane GO:0009897 9.72 CD40LG HLA-DRB1 IL17A IL6 TNF
4 extracellular matrix GO:0031012 9.63 ACAN ADAMTS5 COMP MMP1 MMP13 MMP3
5 extracellular region GO:0005576 9.5 ACAN ADAMTS5 CD40LG COMP CRP IL17A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.94 IL6 TNF TNFRSF10A TNFRSF1B
2 leukocyte migration GO:0050900 9.93 IL1B MMP1 TNF TNFRSF10A
3 response to lipopolysaccharide GO:0032496 9.9 IL1B IL6 TNFRSF10A TNFRSF1B
4 positive regulation of protein kinase B signaling GO:0051897 9.82 IL6 TNF TNFSF11
5 response to glucocorticoid GO:0051384 9.81 IL1RN IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.8 CRP IL6 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 CD40LG IL1B IL6 TNF TNFSF11
8 positive regulation of JNK cascade GO:0046330 9.79 IL1B TNF TNFSF11
9 collagen catabolic process GO:0030574 9.79 MMP1 MMP13 MMP3
10 positive regulation of T cell proliferation GO:0042102 9.78 CD40LG IL1B IL6
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.77 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
12 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B IL6 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 IL1B IL6 TNF
14 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF TNFRSF10A TNFRSF1B
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL1B TNF
16 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.65 IL1B IL6 PHB2 TNF TNFSF11
17 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.63 IL17A TNF TNFSF11
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF TNFRSF1B
20 inflammatory response GO:0006954 9.61 CD40LG CRP IL17A IL1B IL1RN IL6
21 regulation of establishment of endothelial barrier GO:1903140 9.59 IL1B TNF
22 growth plate cartilage development GO:0003417 9.58 COMP MMP13
23 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
24 positive regulation of fever generation GO:0031622 9.57 IL1B TNF
25 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
26 extracellular matrix disassembly GO:0022617 9.55 ACAN ADAMTS5 MMP1 MMP13 MMP3
27 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
28 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
29 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.49 IL1RN IL6
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IL1B TNF
31 immune response GO:0006955 9.32 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.8 ACAN COMP CRP MMP1 MMP13 MMP3
2 metallopeptidase activity GO:0008237 9.56 ADAMTS5 MMP1 MMP13 MMP3
3 metalloendopeptidase activity GO:0004222 9.46 ADAMTS5 MMP1 MMP13 MMP3
4 cytokine activity GO:0005125 9.17 CD40LG IL17A IL1B IL1RN IL6 TNF
5 tumor necrosis factor receptor binding GO:0005164 9.13 CD40LG TNF TNFSF11

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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