MCID: BNM001
MIFTS: 54

Bone Marrow Cancer malady

Cancer diseases, Bone diseases, Immune diseases categories

Summaries for Bone Marrow Cancer

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FGFR1OP antibody
NRAS antibody
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Wikipedia:64 Multiple myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as plasma cell myeloma,... more...

MalaCards based summary: Bone Marrow Cancer, also known as myeloproliferative disorder, is related to acute promyelocytic leukemia and noonan syndrome. An important gene associated with Bone Marrow Cancer is FGFR1OP (FGFR1 oncogene partner), and among its related pathways are CNTF Signaling and Tyrosine Kinases / Adaptors. The drug sodium phenylbutyrate and the compounds ponatinib and nucleoside have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and kidney, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Disease Ontology:9 A hematopoietic cancer that derives from the blood-forming stem cells of the bone marrow.

Aliases & Classifications for Bone Marrow Cancer

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 10diseasecard, 46OMIM, 44Novoseek, 23GTR, 34MeSH, 56SNOMED-CT, 26ICD10
See all sources

Bone Marrow Cancer, Aliases & Descriptions:

Name: Bone Marrow Cancer 9 11
Myeloproliferative Disorder 9 10 46
Myeloproliferative Neoplasm 9 44 61
Myeloproliferative Disease 9 23 61
Primary Malignant Neoplasm of Bone Marrow 9 61
Myeloproliferative Disorders 44 61
Malignant Bone Marrow Tumor 9 61
Myeloproliferative Tumors 9 61
Neoplasm of Bone Marrow 9 61
Bone Marrow Neoplasm 9 61
 
Bone Marrow Tumor 9 61
Myeloid Neoplasm 9 61
Myeloproliferative Disease, No Icd-O Subtype 9
Malignant Neoplasm of Bone Marrow, Nos 61
Chronic Myeloproliferative Disorder 61
Malignant Neoplasm of Bone Marrow 9
Myeloproliferative Disease, Nos 9
Myeloproliferative Disease Nos 9
Bone Marrow Neoplasms 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:4960
MeSH34 D009196
ICD1026 D47.1
UMLS61 C002702

Related Diseases for Bone Marrow Cancer

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Diseases related to Bone Marrow Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1acute promyelocytic leukemia30.6FLT3, NRAS
2noonan syndrome30.6NRAS, KRAS
3juvenile myelomonocytic leukemia30.3NRAS, KRAS, FLT3
4acute leukemia30.0ABL1, FLT3, KRAS
5leukemia30.0ABL1, NRAS, FLT3, KRAS
6acute lymphoblastic leukemia30.0ABL1, FLT3, KRAS
7chronic lymphocytic leukemia29.8ABL1, FLT3
8myelodysplastic syndromes29.5NRAS, ABL1, KRAS, FLT3
9melanoma29.5NRAS, KRAS, FLT3, ABL1
10chronic myeloid leukemia29.4ABL1, FLT3, NRAS, KRAS
11breast cancer29.3KRAS, NRAS, FLT3, ABL1
12down syndrome10.9
13eosinophilia10.5
14chronic myeloproliferative disease10.5
15hepatitis10.4
16thrombocytosis10.4
17myeloproliferative disorder with eosinophilia10.4
18venous thrombosis10.4
19erythromelalgia10.4
20portal vein thrombosis10.4
21essential thrombocythemia10.4
22pdgfrb-associated chronic eosinophilic leukemia10.4
23cerebritis10.4
24venous thromboembolism10.3
25chronic myelomonocytic leukemia10.3
26hypertension10.3
27acquired von willebrand syndrome10.3
28hepatic vein thrombosis10.2
29lymphoblastic leukemia10.2
30hypereosinophilic syndrome10.2
31mastocytosis10.2
32endotheliitis10.2
33unclassified chronic myeloproliferative disease10.2
34myeloid leukemia10.2
35myeloid neoplasm associated with fgfr1 rearrangement10.2
36pdgfra-associated chronic eosinophilic leukemia10.2
37refractory anemia10.2
38lymphoblastic lymphoma10.2
39systemic mastocytosis10.2
40hemorrhagic thrombocythemia10.2
41portal hypertension10.2
42vasculitis10.2
43hydrops fetalis10.2
44splenomegaly10.2
45acute myeloid leukemia10.1
46myeloid neoplasm associated with pdgfrb rearrangement10.1
47myeloid neoplasm associated with pdgfra rearrangement10.1
48exanthem10.1NRAS, KRAS
49gallbladder cancer10.1KRAS, NRAS
50lynch syndrome10.1NRAS, KRAS

Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Symptoms for Bone Marrow Cancer

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Drugs & Therapeutics for Bone Marrow Cancer

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Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Bone Marrow Cancer

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Genetic tests related to Bone Marrow Cancer:

id Genetic test Affiliating Genes
1 Myeloproliferative Disorder23

Anatomical Context for Bone Marrow Cancer

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MalaCards organs/tissues related to Bone Marrow Cancer:

32
Bone marrow, Bone, Kidney, Myeloid

Animal Models for Bone Marrow Cancer or affiliated genes

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MGI Mouse Phenotypes related to Bone Marrow Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6FLT3, NRAS, KRAS
2MP:00053708.3KRAS, NRAS, ABL1
3MP:00053978.1KRAS, NRAS, FLT3, ABL1
4MP:00053878.0KRAS, NRAS, FLT3, ABL1
5MP:00053788.0KRAS, NRAS, FLT3, ABL1
6MP:00053847.9ABL1, FLT3, NRAS, KRAS

Publications for Bone Marrow Cancer

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Articles related to Bone Marrow Cancer:

idTitleAuthorsYear
1
Mayo breakthrough: virus may destroy bone marrow cancer. (25233543)
2014
2
Erythrokinetics and androgens in bone marrow cancer. (975001)
1976

Variations for Bone Marrow Cancer

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Expression for genes affiliated with Bone Marrow Cancer

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Expression patterns in normal tissues for genes affiliated with Bone Marrow Cancer

Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

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Pathways related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3NRAS, FLT3
29.3FLT3, ABL1
3
Show member pathways
9.1KRAS, NRAS
49.1KRAS, NRAS
5
Show member pathways
Signal transduction cAMP signaling59
9.1NRAS, KRAS
6
Show member pathways
9.1KRAS, NRAS
7
Show member pathways
9.1KRAS, NRAS
8
Show member pathways
9.1NRAS, KRAS
9
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway37
9.1KRAS, NRAS
109.1NRAS, KRAS
11
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1NRAS, KRAS
12
Show member pathways
9.1KRAS, NRAS
13
Show member pathways
9.1KRAS, NRAS
149.1KRAS, NRAS
15
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.1KRAS, NRAS
16
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
9.1KRAS, NRAS
17
Show member pathways
9.1NRAS, KRAS
18
Show member pathways
9.1NRAS, KRAS
199.1NRAS, KRAS
209.1KRAS, NRAS
219.1KRAS, NRAS
22
Show member pathways
9.1KRAS, NRAS
23
Show member pathways
9.1KRAS, NRAS
249.1KRAS, NRAS
25
Show member pathways
9.1KRAS, NRAS
26
Show member pathways
EGFR-dependent Endothelin signaling events37
9.1KRAS, NRAS
27
Show member pathways
9.1KRAS, NRAS
289.1KRAS, NRAS
29
Show member pathways
9.1NRAS, KRAS
309.1KRAS, NRAS
319.1ABL1, KRAS
32
Show member pathways
8.8NRAS, FLT3, ABL1
33
Show member pathways
8.7FGFR1OP, KRAS, NRAS
348.7NRAS, KRAS, FGFR1OP
35
Show member pathways
8.7FGFR1OP, KRAS, NRAS
36
Show member pathways
8.7NRAS, KRAS, FGFR1OP
37
Show member pathways
8.6ABL1, NRAS, KRAS
38
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.6KRAS, NRAS, ABL1
398.6KRAS, NRAS, ABL1
40
Show member pathways
8.6KRAS, NRAS, ABL1
41
Show member pathways
8.6ABL1, NRAS, KRAS
428.6KRAS, NRAS, ABL1
43
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.6ABL1, NRAS, KRAS
44
Show member pathways
8.6ABL1, NRAS, KRAS
45
Show member pathways
Signal transduction PTEN pathway59
8.5FLT3, NRAS, KRAS
46
Show member pathways
8.5FLT3, NRAS, KRAS
478.0KRAS, NRAS, FLT3, ABL1

Compounds for genes affiliated with Bone Marrow Cancer

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Compounds related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1ponatinib50 1210.6ABL1, FLT3
2nucleoside449.3ABL1, FLT3
3regorafenib50 1210.3KRAS, ABL1
4herbimycin a44 6010.3FLT3, ABL1
5cytarabine44 50 1211.2FLT3, ABL1
6imatinib44 50 1210.7KRAS, FLT3, ABL1
7phosphoinositide448.7KRAS, FLT3, ABL1
8vegf448.6KRAS, FLT3, ABL1
9phosphatidylinositol448.6KRAS, FLT3, ABL1
10oligonucleotide448.2KRAS, NRAS, FLT3, ABL1
11retinoic acid44 259.2KRAS, FLT3, ABL1
12tyrosine448.1ABL1, FLT3, NRAS, KRAS

GO Terms for genes affiliated with Bone Marrow Cancer

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Biological processes related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac protein signal transductionGO:0350229.5KRAS, NRAS
2regulation of synaptic transmission, GABAergicGO:0322289.4NRAS, KRAS
3striated muscle cell differentiationGO:0511469.4KRAS, NRAS
4regulation of long-term neuronal synaptic plasticityGO:0481699.4KRAS, NRAS
5visual learningGO:0085429.4KRAS, NRAS
6activation of MAPKK activityGO:0001869.4NRAS, KRAS
7MAPK cascadeGO:0001659.3KRAS, NRAS
8Ras protein signal transductionGO:0072659.3KRAS, NRAS
9positive regulation of MAP kinase activityGO:0434069.3FLT3, KRAS
10leukocyte migrationGO:0509009.2KRAS, NRAS
11peptidyl-tyrosine phosphorylationGO:0181089.2ABL1, FLT3, FGFR1OP
12negative regulation of neuron apoptotic processGO:0435249.2KRAS, NRAS
13GTP catabolic processGO:0061849.1NRAS, KRAS
14Fc-epsilon receptor signaling pathwayGO:0380959.1KRAS, NRAS
15insulin receptor signaling pathwayGO:0082869.0KRAS, NRAS
16actin cytoskeleton organizationGO:0300368.9KRAS, NRAS, ABL1
17axon guidanceGO:0074118.9ABL1, NRAS, KRAS
18blood coagulationGO:0075968.8KRAS, NRAS, ABL1
19fibroblast growth factor receptor signaling pathwayGO:0085438.8KRAS, NRAS
20innate immune responseGO:0450878.8ABL1, NRAS, KRAS
21positive regulation of cell proliferationGO:0082848.4FGFR1OP, KRAS, NRAS, FLT3

Molecular functions related to Bone Marrow Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.2FGFR1OP, ABL1
2protein complex bindingGO:0324039.1KRAS, NRAS

Products for genes affiliated with Bone Marrow Cancer

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Sources for Bone Marrow Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet