MCID: BNM001
MIFTS: 34

Bone Marrow Cancer malady

Bone diseases, Immune diseases, Cancer diseases categories

Summaries for Bone Marrow Cancer

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66Wikipedia, 34MalaCards
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Wikipedia:66 Plasma cell myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as multiple myeloma,... more...

MalaCards: Bone Marrow Cancer, also known as bone marrow neoplasms, is related to myelodysplastic myeloproliferative cancer and myeloma. An important gene associated with Bone Marrow Cancer is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are CNTF Signaling and Tyrosine Kinases / Adaptors. The compounds ponatinib and agar have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and kidney, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Bone Marrow Cancer

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11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

bone marrow cancer 11
bone marrow neoplasms 63


Related Diseases for Bone Marrow Cancer

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Symptoms for Bone Marrow Cancer

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Drugs & Therapeutics for Bone Marrow Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Bone Marrow Cancer

Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Search CenterWatch for Bone Marrow Cancer

Genetic Tests for Bone Marrow Cancer

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Anatomical Context for Bone Marrow Cancer

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34MalaCards
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MalaCards organs/tissues related to Bone Marrow Cancer:

34
Bone marrow, Bone, Kidney

Animal Models for Bone Marrow Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bone Marrow Cancer:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7KRAS, NRAS, ABL1
2MP:00020068.7KRAS, NRAS, FLT3
3MP:00053818.6ABL1, NRAS, KRAS
4MP:00053808.6KRAS, NRAS, ABL1
5MP:00053918.3KRAS, NRAS, ABL1
6MP:00053978.2KRAS, NRAS, FLT3, ABL1
7MP:00053878.2ABL1, FLT3, NRAS, KRAS
8MP:00053848.2ABL1, FLT3, NRAS, KRAS
9MP:00053788.2ABL1, FLT3, NRAS, KRAS
10MP:00053768.1ABL1, FLT3, NRAS, KRAS
11MP:00107687.9ABL1, FLT3, NRAS, KRAS

Publications for Bone Marrow Cancer

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53PubMed
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Articles related to Bone Marrow Cancer:

idTitleAuthorsYear
1
Erythrokinetics and androgens in bone marrow cancer. (975001)
1976

Variations for Bone Marrow Cancer

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Expression for genes affiliated with Bone Marrow Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Marrow Cancer

Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

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Sources:
51PathCards, 54QIAGEN, 5Cell Signaling Technology, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 58SinoBiological, 62Tocris Bioscience, 55R&D Systems, 52PharmGKB
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Pathways related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3NRAS, FLT3
29.3ABL1, FLT3
3
Show member pathways
Signal transduction cAMP signaling61
9.1KRAS, NRAS
4
Show member pathways
9.1NRAS, KRAS
59.1KRAS, NRAS
6
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.1NRAS, KRAS
7
Show member pathways
9.1NRAS, KRAS
8
Show member pathways
9.1NRAS, KRAS
99.1KRAS, NRAS
10
Show member pathways
9.1KRAS, NRAS
119.1NRAS, KRAS
129.1NRAS, KRAS
13
Show member pathways
Signaling Pathways in Glioblastoma39
9.1KRAS, NRAS
14
Show member pathways
Immune response CD16 signaling in NK cells61
9.1KRAS, NRAS
15
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.1KRAS, NRAS
169.1KRAS, NRAS
17
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1KRAS, NRAS
189.1NRAS, KRAS
19
Show member pathways
9.1KRAS, NRAS
20
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.1NRAS, KRAS
21
Show member pathways
9.1KRAS, NRAS
22
Show member pathways
9.1KRAS, NRAS
23
Show member pathways
9.1KRAS, NRAS
24
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1KRAS, NRAS
25
Show member pathways
9.1KRAS, NRAS
26
Show member pathways
9.1KRAS, NRAS
27
Show member pathways
9.1KRAS, NRAS
289.1KRAS, NRAS
29
Show member pathways
EGFR-dependent Endothelin signaling events39
9.1KRAS, NRAS
309.1KRAS, NRAS
319.1KRAS, NRAS
32
Show member pathways
9.1KRAS, NRAS
33
Show member pathways
9.1NRAS, KRAS
34
Show member pathways
9.1NRAS, KRAS
35
Show member pathways
9.1KRAS, NRAS
369.1NRAS, KRAS
379.1ABL1, KRAS
389.1KRAS, ABL1
39
Show member pathways
8.8NRAS, FLT3, ABL1
408.6KRAS, NRAS, ABL1
41
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
8.6KRAS, NRAS, ABL1
42
Show member pathways
8.6ABL1, NRAS, KRAS
43
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.6ABL1, NRAS, KRAS
44
Show member pathways
8.6ABL1, NRAS, KRAS
45
Show member pathways
8.6KRAS, NRAS, ABL1
46
Show member pathways
8.6ABL1, NRAS, KRAS
478.6ABL1, NRAS, KRAS
48
Show member pathways
Signal transduction PTEN pathway61
8.5FLT3, NRAS, KRAS
49
Show member pathways
8.5KRAS, NRAS, FLT3
508.0KRAS, NRAS, FLT3, ABL1

Compounds for genes affiliated with Bone Marrow Cancer

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 62Tocris Bioscience, 25HMDB
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Compounds related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ponatinib52 1210.6ABL1, FLT3
2agar469.4NRAS, ABL1
3nucleoside469.4ABL1, FLT3
4regorafenib52 1210.3KRAS, ABL1
5cytarabine46 52 1211.2ABL1, FLT3
6herbimycin a46 6210.0FLT3, ABL1
7imatinib46 52 1210.8KRAS, FLT3, ABL1
8phosphoinositide468.7KRAS, FLT3, ABL1
9vegf468.7KRAS, FLT3, ABL1
10phosphatidylinositol468.6KRAS, FLT3, ABL1
11retinoic acid46 259.5KRAS, FLT3, ABL1
12oligonucleotide468.3KRAS, NRAS, FLT3, ABL1
13tyrosine468.2ABL1, FLT3, NRAS, KRAS

GO Terms for genes affiliated with Bone Marrow Cancer

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Sources:
17Gene Ontology
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Biological processes related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.5FLT3, ABL1
2positive regulation of Rac protein signal transductionGO:0350229.5KRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:0322289.5NRAS, KRAS
4striated muscle cell differentiationGO:0511469.5KRAS, NRAS
5regulation of long-term neuronal synaptic plasticityGO:0481699.5KRAS, NRAS
6visual learningGO:0085429.4KRAS, NRAS
7activation of MAPKK activityGO:0001869.4NRAS, KRAS
8MAPK cascadeGO:0001659.4KRAS, NRAS
9Ras protein signal transductionGO:0072659.4NRAS, KRAS
10positive regulation of MAP kinase activityGO:0434069.3KRAS, FLT3
11leukocyte migrationGO:0509009.3KRAS, NRAS
12negative regulation of neuron apoptotic processGO:0435249.3NRAS, KRAS
13GTP catabolic processGO:0061849.2KRAS, NRAS
14insulin receptor signaling pathwayGO:0082869.2KRAS, NRAS
15fibroblast growth factor receptor signaling pathwayGO:0085439.1NRAS, KRAS
16Fc-epsilon receptor signaling pathwayGO:0380959.0KRAS, NRAS
17cytokine-mediated signaling pathwayGO:0192219.0KRAS, FLT3
18actin cytoskeleton organizationGO:0300369.0KRAS, NRAS, ABL1
19axon guidanceGO:0074118.9ABL1, NRAS, KRAS
20blood coagulationGO:0075968.9ABL1, NRAS, KRAS
21innate immune responseGO:0450878.9KRAS, NRAS, ABL1
22epidermal growth factor receptor signaling pathwayGO:0071738.8KRAS, NRAS
23positive regulation of cell proliferationGO:0082848.8KRAS, NRAS, FLT3

Molecular functions related to Bone Marrow Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1KRAS, NRAS

Products for genes affiliated with Bone Marrow Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Marrow Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet