MCID: BNM001
MIFTS: 38

Bone Marrow Cancer malady

Bone, Immune, Cancer categories

Summaries for Bone Marrow Cancer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

MalaCards: Bone Marrow Cancer, also known as bone marrow neoplasms, is related to papular mucinosis and polycythemia. An important gene associated with Bone Marrow Cancer is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are SHC1 events in ERBB2 signaling and ARMS-mediated activation. The compounds daniplestim and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and colon, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Bone Marrow Cancer

Sources:
10DISEASES, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone, Immune


Aliases & Descriptions:

bone marrow cancer 10
bone marrow neoplasms 61


Related Diseases for Bone Marrow Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bone Marrow Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1papular mucinosis10.1
2polycythemia10.0IL3
3eosinophilia10.0IL3
4mastocytosis10.0KIT
5adenocarcinoma10.0KRAS
6chronic myeloproliferative disease10.0FLT3
7hepatitis10.0KRAS
8testicular cancer10.0KRAS
9uterine sarcoma10.0KIT
10rhabdoid tumor10.0BCR
11germ cell tumors10.0KIT
12astrocytoma10.0BCR
13dermatofibrosarcoma protuberans10.0KIT
14severe combined immunodeficiency10.0IL3, FLT3
15myelofibrosis10.0IL3, KIT
16thyroid cancer10.0ABL1, FLT3
17hypereosinophilic syndrome10.0IL3, KIT
18pancreatitis10.0KRAS, NRAS
19colorectal cancer10.0KRAS, NRAS
20pancreatic cancer10.0KRAS, NRAS
21hairy cell leukemia10.0IL3, FLT3
22hemorrhagic thrombocythemia10.0KIT, IL3
23myeloid sarcoma10.0FLT3, KIT
24acute myeloid leukemia10.0KIT, FLT3
25exanthem10.0KRAS, NRAS
26acute myeloid leukemia, adult10.0FLT3, KIT
27lung cancer10.0KRAS, NRAS
28glioblastoma multiforme10.0ABL1, KIT
29myeloma10.0BCR, IL3
30cholangiocarcinoma10.0NRAS, KRAS
31acute promyelocytic leukemia10.0IL3, NRAS, FLT3
32malignant mixed mullerian tumor10.0KRAS, KIT
33polycythemia vera10.0KIT, IL3, FLT3
34refractory anemia10.0FLT3, IL3, KIT
35mast cell neoplasm10.0FLT3, IL3, KIT
36colon cancer10.0KRAS, ABL1
37deficiency anemia10.0FLT3, IL3, ABL1
38wilms tumor10.0ABL1, FLT3
39juvenile myelomonocytic leukemia10.0KRAS, NRAS, FLT3
40factor vii deficiency10.0KRAS, KIT
41sarcoma10.0KRAS, KIT, NRAS
42aplastic anemia10.0IL3, FLT3
43neurofibromatosis10.0KIT, KRAS
44lung small cell carcinoma10.0IL3, KIT, KRAS
45hodgkin's lymphoma10.0FLT3, IL3, BCR
46chronic myelomonocytic leukemia10.0FLT3, KIT, BCR
47chronic lymphocytic leukemia10.0BCR, ABL1, FLT3
48non-hodgkin lymphoma10.0FLT3, ZMYM2, IL3, BCR
49retinoblastoma10.0BCR, KRAS, ABL1
50precursor t-cell acute lymphoblastic leukemia10.0FLT3, IL3, ABL1, BCR

Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Clinical Features for Bone Marrow Cancer

Drugs & Therapeutics for Bone Marrow Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Bone Marrow Cancer

Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Search CenterWatch for Bone Marrow Cancer

Genetic Tests for Bone Marrow Cancer

Anatomical Context for Bone Marrow Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Bone Marrow Cancer:

33
Bone marrow, Lymph node, Colon, Kidney, Liver, Lung, Breast, Prostate, T cells, Endothelial, Tongue

Animal Models for Bone Marrow Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bone Marrow Cancer

Sources:
51PubMed
See all sources

Articles related to Bone Marrow Cancer:

(show top 50)    (show all 224)
idTitleAuthorsYear
1
Over-Expression of Cancerous Inhibitor of PP2A (CIP2A) in Bone Marrow Cells from Patients with a Group of High-Risk Myelodysplastic Syndromes. (24163288)
2013
2
The HER2 status of disseminated tumor cells in the bone marrow of early breast cancer patients is independent from primary tumor and predicts higher risk of relapse. (23494674)
2013
3
Clinical significance of molecular detection of matrix metalloproteinase-1 in bone marrow and peripheral blood in patients with gastric cancer. (21761103)
2012
4
Prognostic significance of methylated RASSF1A and PITX2 genes in blood- and bone marrow plasma of breast cancer patients. (21221769)
2011
5
Human prostate cancer harbors the stem cell properties of bone marrow mesenchymal stem cells. (21355075)
2011
6
Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients. (20705613)
2010
7
Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer. (19569245)
2009
8
Bone marrow cytokeratin 19 mRNA level is an independent predictor of relapse-free survival in operable breast cancer patients. (17492378)
2008
9
Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner. (18324629)
2008
10
Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells. (18409043)
2008
11
Molecular detection of disseminated breast cancer cells in the bone marrow of early breast cancer patients using quantitative RT PCR for CEA. (18505343)
2008
12
Bone marrow-derived cells contribute to niche formation in cancer progression]. (18379030)
2008
13
Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients. (17785550)
2007
14
PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro. (17390372)
2007
15
Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. (16652145)
2006
16
Prostate cancer cells regulate growth and differentiation of bone marrow endothelial cells through TGFbeta and its receptor, TGFbetaRII. (16388503)
2006
17
Molecular staging of bladder cancer with RT-PCR assay for CK20 in peripheral blood, bone marrow and lymph nodes: comparison with standard histological staging. (16475726)
2006
18
The effects of interleukin 10 and interferon gamma cytokine gene polymorphisms on survival after autologous bone marrow transplantation for patients with breast cancer. (15931634)
2005
19
Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. (16368946)
2005
20
Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. (15569677)
2005
21
Detection of bone marrow micrometastases in patients with gallbladder cancer]. (15743160)
2004
22
Molecular staging by RT-pCR analysis for PSA and PSMA in peripheral blood and bone marrow samples is an independent predictor of time to biochemical failure following radical prostatectomy for clinically localized prostate cancer. (15679047)
2004
23
Human bone marrow stromal cells protect prostate cancer cells from TRAIL-induced apoptosis. (15355567)
2004
24
Value of diagnosing micrometastasis by nested RT-PCR in the peripheral blood and bone marrow in non-small cell lung cancer patients]. (12678991)
2003
25
Detection of bone marrow-disseminated breast cancer cells using an RT-PCR assay of MUC5B mRNA. (12478674)
2003
26
Minimal residual disease in gastric cancer: evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow. (11956259)
2002
27
Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. (11533316)
2001
28
Evaluation of MUC1 and EGP40 in bone marrow and peripheral blood as a marker for occult breast cancer. (11205703)
2001
29
Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. (11230493)
2001
30
A case with extraosseous Ewing's sarcoma: a late effect related to bone marrow transplantation for thalassemia or a component of a familial cancer syndrome? (10914053)
2000
31
Detection of micrometastasis in bone marrow of pancreatic cancer patients. (10436799)
1999
32
Comparative immunocytochemical assessment of isolated carcinoma cells in lymph nodes and bone marrow of patients with clinically localized prostate cancer. (10096246)
1999
33
Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor. (10514409)
1999
34
Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy. (9890659)
1998
35
Immunosuppressive cells in bone marrow of patients with stomach cancer. (10026871)
1998
36
Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer. (8996359)
1997
37
In vitro production of human antigen presenting cells issued from bone marrow of patients with cancer. (9395898)
1997
38
The effect of the GM-CSF/IL-3 fusion protein PIXY321 on bone marrow and circulating haemopoietic cells of previously untreated patients with cancer. (8611477)
1996
39
Erythroderma after autologous bone marrow transplantation modified by administration of cyclosporine and interferon gamma for breast cancer. (8609251)
1996
40
Disseminated epithelial tumor cells in bone marrow of patients with esophageal cancer: detection and prognostic significance. (8661632)
1996
41
Effect of cyclosporin A on human bone marrow granulocyte-macrophage progenitors with anti-cancer agents. (8533588)
1995
42
A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. (7478596)
1995
43
Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells. (7835423)
1995
44
Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide. (7666093)
1995
45
Micrometastasis in bone marrow in breast cancer. (7959982)
1994
46
Immunocytochemical detection and phenotypic characterization of micrometastatic tumour cells in bone marrow of patients with prostate cancer. (7521088)
1994
47
Expression of excision repair genes in non-malignant bone marrow from cancer patients. (7678143)
1993
48
Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid cancer. (1903847)
1991
49
Examination of bone marrow biopsy specimens and staging of small cell lung cancer. (1963546)
1990
50
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990

Genetic Variations for Bone Marrow Cancer

Expression for genes affiliated with Bone Marrow Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bone Marrow Cancer

Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

Sources:
54Reactome, 30KEGG, 50PharmGKB, 52QIAGEN, 60Tocris Bioscience, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Pathways related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6NRAS, KRAS
2
Hide members
9.6KRAS, NRAS
39.6KRAS, NRAS
4
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9.6KRAS, NRAS
5
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9.6NRAS, KRAS
69.6NRAS, KRAS
79.6KRAS, NRAS
8
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9.4IL3, NRAS, FLT3
9
Hide members
9.4BCR, KIT
10
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9.3KIT, NRAS, FLT3
11
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9.3KRAS, IL3, NRAS
12
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9.3KRAS, IL3, NRAS
13
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9.3NRAS, IL3, KRAS
149.3FLT3, IL3, KIT
15
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9.2KRAS, KIT, NRAS
16
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9.2KRAS, KIT, NRAS
17
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9.2KRAS, KIT, NRAS
18
Hide members
9.2KRAS, KIT, NRAS
19
Hide members
9.2NRAS, KIT, KRAS
209.1KRAS, ABL1, NRAS
21
Hide members
9.1NRAS, ABL1, KRAS
229.1NRAS, ABL1, KRAS
23
Hide members
9.1NRAS, ABL1, KRAS
249.1IL3, ABL1, KRAS
25
Hide members
8.9KIT, IL3, NRAS, FLT3
26
Hide members
8.9KIT, IL3, NRAS, FLT3
27
Hide members
8.9FLT3, NRAS, IL3, KIT
28
Hide members
8.9KIT, IL3, NRAS, FLT3
29
Hide members
8.9KIT, IL3, NRAS, FLT3
30
Hide members
8.9FLT3, NRAS, IL3, KIT
318.8NRAS, IL3, KIT, KRAS
32
Hide members
8.8KIT, ABL1, IL3, NRAS
33
Hide members
8.8FLT3, NRAS, KIT, KRAS
34
Hide members
8.6ZMYM2, NRAS, KRAS, BCR
35
Hide members
8.5BCR, KRAS, ABL1, NRAS
368.5BCR, KIT, ABL1, FLT3
37
Hide members
8.4KIT, ABL1, IL3, NRAS, FLT3
38
Hide members
8.2ZMYM2, NRAS, KIT, KRAS, BCR
398.2ZMYM2, NRAS, KIT, KRAS, BCR
407.6BCR, KRAS, KIT, ABL1, NRAS, FLT3

Compounds for genes affiliated with Bone Marrow Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1daniplestim4510.1FLT3, IL3
2pixy3214510.1FLT3, IL3
3idarubicin45 50 1112.0IL3, FLT3
4tandutinib4510.0KIT, FLT3
5rhodamine 12345 5011.0KIT, IL3
6pkc 4124510.0KIT, FLT3
7su5416459.9KIT, FLT3
8sunitinib45 50 1111.9KIT, FLT3
9nilotinib50 1110.9KIT, ABL1
10Regorafenib119.8ABL1, KIT
11fluorochrome459.7KIT, BCR
12ag-1296459.7KIT, IL3, FLT3
1317-(allylamino)-17-demethoxygeldanamycin459.7KIT, FLT3
14methylcellulose459.7KIT, IL3, FLT3
15leucovorin45 50 1111.6KRAS, IL3
16adp45 29 2411.6BCR, FLT3
17herbimycin a45 6010.5FLT3, IL3, ABL1
18paclitaxel45 50 1111.5KRAS, IL3
19Ponatinib 119.5FLT3, ABL1, KIT
20agar459.5NRAS, IL3, ABL1
21valine459.5KRAS, KIT, IL3
225fluorouracil459.4KRAS, KIT, IL3
23dasatinib45 50 1111.3ABL1, KIT, BCR
24erlotinib45 50 1111.2KRAS, KIT
25rapamycin459.1KRAS, KIT, IL3, FLT3
26phenylalanine459.1ABL1, KIT, BCR
27gp 130459.1FLT3, IL3, KIT, BCR
28thymidine45 2410.0BCR, KIT, IL3, FLT3
29h2o2458.8IL3, ABL1, KRAS, BCR
30vegf458.7KRAS, KIT, ABL1, FLT3
31retinoic acid45 249.6FLT3, IL3, ABL1, KIT, KRAS
32cytarabine45 50 1110.5FLT3, IL3, ABL1, KIT, BCR
33phosphotyrosine458.5FLT3, IL3, ABL1, KIT, BCR
34threonine458.5FLT3, IL3, ABL1, KIT, BCR
35Adenosine triphosphate11 249.5FLT3, ABL1, KIT, BCR
36phosphoinositide458.3BCR, KRAS, KIT, ABL1, FLT3
37serine458.2IL3, ABL1, KIT, KRAS, BCR
38oligonucleotide458.0FLT3, NRAS, ABL1, KIT, KRAS, BCR
39imatinib45 50 1110.0BCR, KRAS, KIT, ABL1, IL3, FLT3
40phosphatidylinositol458.0BCR, KRAS, KIT, ABL1, IL3, FLT3
41tyrosine457.3FLT3, ZMYM2, NRAS, IL3, ABL1, KIT

GO Terms for genes affiliated with Bone Marrow Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0KIT, IL3
2positive regulation of Rac protein signal transductionGO:03502210.0KRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:03222810.0KRAS, NRAS
4striated muscle cell differentiationGO:05114610.0KRAS, NRAS
5embryonic hemopoiesisGO:03516210.0IL3, KIT
6myeloid progenitor cell differentiationGO:00231810.0FLT3, KIT
7regulation of long-term neuronal synaptic plasticityGO:0481699.9KRAS, NRAS
8positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8KIT, FLT3
9visual learningGO:0085429.7KRAS, NRAS
10positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.6FLT3, KIT
11positive regulation of MAP kinase activityGO:0434069.6KRAS, FLT3
12activation of MAPKK activityGO:0001869.5KRAS, NRAS
13platelet-derived growth factor receptor signaling pathwayGO:0480089.5BCR, ABL1
14fibroblast growth factor receptor signaling pathwayGO:0085439.5KRAS, KIT, NRAS
15peptidyl-tyrosine phosphorylationGO:0181089.4FLT3, ABL1, KIT
16Fc-epsilon receptor signaling pathwayGO:0380959.4KRAS, KIT, NRAS
17epidermal growth factor receptor signaling pathwayGO:0071739.4NRAS, KIT, KRAS
18neurotrophin TRK receptor signaling pathwayGO:0480119.3KRAS, KIT, NRAS
19protein autophosphorylationGO:0467779.3FLT3, KIT, BCR
20cytokine-mediated signaling pathwayGO:0192219.3FLT3, KIT, KRAS
21hemopoiesisGO:0300979.1KIT, CD164, FLT3
22small GTPase mediated signal transductionGO:0072649.0BCR, KRAS, NRAS
23innate immune responseGO:0450878.9KRAS, KIT, ABL1, NRAS
24actin cytoskeleton organizationGO:0300368.9BCR, KRAS, ABL1, NRAS
25axon guidanceGO:0074118.8KRAS, ABL1, NRAS
26positive regulation of cell proliferationGO:0082848.8FLT3, NRAS, IL3, KIT, KRAS

Molecular functions related to Bone Marrow Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, FLT3
2protein tyrosine kinase activityGO:0047138.6BCR, KIT, ABL1

Products for genes affiliated with Bone Marrow Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Marrow Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet