MCID: BNM001
MIFTS: 34

Bone Marrow Cancer malady

Bone diseases, Immune diseases, Cancer diseases categories
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Summaries for Bone Marrow Cancer

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Plasma cell myeloma (myelo- + -oma, \"marrow\" + \"tumor\"), also known as multiple myeloma,... more...

MalaCards: Bone Marrow Cancer, also known as bone marrow neoplasms, is related to myelodysplastic myeloproliferative cancer and myeloma. An important gene associated with Bone Marrow Cancer is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are CNTF Signaling and Tyrosine Kinases / Adaptors. The compounds ponatinib and agar have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and kidney, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Bone Marrow Cancer

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10DISEASES, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

bone marrow cancer 10
bone marrow neoplasms 62


Related Diseases for Bone Marrow Cancer

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Symptoms for Bone Marrow Cancer

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Drugs & Therapeutics for Bone Marrow Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Genetic Tests for Bone Marrow Cancer

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Anatomical Context for Bone Marrow Cancer

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33MalaCards
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MalaCards organs/tissues related to Bone Marrow Cancer:

33
Bone marrow, Bone, Kidney

Animal Models for Bone Marrow Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bone Marrow Cancer:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7KRAS, NRAS, ABL1
2MP:00020068.7KRAS, NRAS, FLT3
3MP:00053818.6ABL1, NRAS, KRAS
4MP:00053808.6KRAS, NRAS, ABL1
5MP:00053918.3KRAS, NRAS, ABL1
6MP:00053978.2KRAS, NRAS, FLT3, ABL1
7MP:00053878.2ABL1, FLT3, NRAS, KRAS
8MP:00053848.2ABL1, FLT3, NRAS, KRAS
9MP:00053788.2ABL1, FLT3, NRAS, KRAS
10MP:00053768.1ABL1, FLT3, NRAS, KRAS
11MP:00107687.9ABL1, FLT3, NRAS, KRAS

Publications for Bone Marrow Cancer

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52PubMed
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Articles related to Bone Marrow Cancer:

idTitleAuthorsYear
1
Erythrokinetics and androgens in bone marrow cancer. (975001)
1976

Variations for Bone Marrow Cancer

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Expression for genes affiliated with Bone Marrow Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Marrow Cancer

Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

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Sources:
50PathCards, 53QIAGEN, 5Cell Signaling Technology, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 55Reactome, 57SinoBiological, 61Tocris Bioscience, 54R&D Systems, 51PharmGKB
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Pathways related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3NRAS, FLT3
29.3ABL1, FLT3
3
Show member pathways
Signal transduction cAMP signaling60
9.1KRAS, NRAS
4
Show member pathways
9.1NRAS, KRAS
59.1KRAS, NRAS
6
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1NRAS, KRAS
7
Show member pathways
9.1NRAS, KRAS
8
Show member pathways
9.1NRAS, KRAS
99.1KRAS, NRAS
10
Show member pathways
9.1KRAS, NRAS
119.1NRAS, KRAS
129.1NRAS, KRAS
13
Show member pathways
Signaling Pathways in Glioblastoma38
9.1KRAS, NRAS
14
Show member pathways
Immune response CD16 signaling in NK cells60
9.1KRAS, NRAS
15
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.1KRAS, NRAS
169.1KRAS, NRAS
17
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1KRAS, NRAS
189.1NRAS, KRAS
19
Show member pathways
9.1KRAS, NRAS
20
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.1NRAS, KRAS
21
Show member pathways
9.1KRAS, NRAS
22
Show member pathways
9.1KRAS, NRAS
23
Show member pathways
9.1KRAS, NRAS
24
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.1KRAS, NRAS
25
Show member pathways
9.1KRAS, NRAS
26
Show member pathways
9.1KRAS, NRAS
27
Show member pathways
9.1KRAS, NRAS
289.1KRAS, NRAS
29
Show member pathways
EGFR-dependent Endothelin signaling events38
9.1KRAS, NRAS
309.1KRAS, NRAS
319.1KRAS, NRAS
32
Show member pathways
9.1KRAS, NRAS
33
Show member pathways
9.1NRAS, KRAS
34
Show member pathways
9.1NRAS, KRAS
35
Show member pathways
9.1KRAS, NRAS
369.1NRAS, KRAS
379.1ABL1, KRAS
389.1KRAS, ABL1
39
Show member pathways
8.8NRAS, FLT3, ABL1
408.6KRAS, NRAS, ABL1
41
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
8.6KRAS, NRAS, ABL1
42
Show member pathways
8.6ABL1, NRAS, KRAS
43
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.6ABL1, NRAS, KRAS
44
Show member pathways
8.6ABL1, NRAS, KRAS
45
Show member pathways
8.6KRAS, NRAS, ABL1
46
Show member pathways
8.6ABL1, NRAS, KRAS
478.6ABL1, NRAS, KRAS
48
Show member pathways
Signal transduction PTEN pathway60
8.5FLT3, NRAS, KRAS
49
Show member pathways
8.5KRAS, NRAS, FLT3
508.0KRAS, NRAS, FLT3, ABL1

Compounds for genes affiliated with Bone Marrow Cancer

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Sources:
51PharmGKB, 11DrugBank, 45Novoseek, 61Tocris Bioscience, 24HMDB
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Compounds related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ponatinib51 1110.6ABL1, FLT3
2agar459.4NRAS, ABL1
3nucleoside459.4ABL1, FLT3
4regorafenib51 1110.3KRAS, ABL1
5cytarabine45 51 1111.2ABL1, FLT3
6herbimycin a45 6110.0FLT3, ABL1
7imatinib45 51 1110.8KRAS, FLT3, ABL1
8phosphoinositide458.7KRAS, FLT3, ABL1
9vegf458.7KRAS, FLT3, ABL1
10phosphatidylinositol458.6KRAS, FLT3, ABL1
11retinoic acid45 249.5KRAS, FLT3, ABL1
12oligonucleotide458.3KRAS, NRAS, FLT3, ABL1
13tyrosine458.2ABL1, FLT3, NRAS, KRAS

GO Terms for genes affiliated with Bone Marrow Cancer

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16Gene Ontology
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Biological processes related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.5FLT3, ABL1
2positive regulation of Rac protein signal transductionGO:0350229.5KRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:0322289.5NRAS, KRAS
4striated muscle cell differentiationGO:0511469.5KRAS, NRAS
5regulation of long-term neuronal synaptic plasticityGO:0481699.5KRAS, NRAS
6visual learningGO:0085429.4KRAS, NRAS
7activation of MAPKK activityGO:0001869.4NRAS, KRAS
8MAPK cascadeGO:0001659.4KRAS, NRAS
9Ras protein signal transductionGO:0072659.4NRAS, KRAS
10positive regulation of MAP kinase activityGO:0434069.3KRAS, FLT3
11leukocyte migrationGO:0509009.3KRAS, NRAS
12negative regulation of neuron apoptotic processGO:0435249.3NRAS, KRAS
13GTP catabolic processGO:0061849.2KRAS, NRAS
14insulin receptor signaling pathwayGO:0082869.2KRAS, NRAS
15fibroblast growth factor receptor signaling pathwayGO:0085439.1NRAS, KRAS
16Fc-epsilon receptor signaling pathwayGO:0380959.0KRAS, NRAS
17cytokine-mediated signaling pathwayGO:0192219.0KRAS, FLT3
18actin cytoskeleton organizationGO:0300369.0KRAS, NRAS, ABL1
19axon guidanceGO:0074118.9ABL1, NRAS, KRAS
20blood coagulationGO:0075968.9ABL1, NRAS, KRAS
21innate immune responseGO:0450878.9KRAS, NRAS, ABL1
22epidermal growth factor receptor signaling pathwayGO:0071738.8KRAS, NRAS
23positive regulation of cell proliferationGO:0082848.8KRAS, NRAS, FLT3

Molecular functions related to Bone Marrow Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:0324039.1KRAS, NRAS

Products for genes affiliated with Bone Marrow Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Marrow Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet