MCID: BNM001
MIFTS: 43

Bone Marrow Cancer malady

Bone diseases, Immune diseases, Cancer diseases categories

Summaries for Bone Marrow Cancer

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Disease Ontology:9 A hematopoietic cancer that derives from the blood-forming stem cells of the bone marrow.

MalaCards based summary: Bone Marrow Cancer, also known as primary malignant neoplasm of bone marrow, is related to precursor b-cell acute lymphoblastic leukemia and myeloid leukemia. An important gene associated with Bone Marrow Cancer is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are CNTF Signaling and Tyrosine Kinases / Adaptors. The drug sodium phenylbutyrate and the compounds ponatinib and agar have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and myeloid, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Bone Marrow Cancer

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Bone Marrow Cancer, Aliases & Descriptions:

Name: Bone Marrow Cancer 9 11
Primary Malignant Neoplasm of Bone Marrow 9 60
Malignant Neoplasm of Bone Marrow 9 60
Myeloproliferative Disorders 43 22
Myeloproliferative Neoplasm 9 43
Myeloproliferative Disorder 9 10
Myeloproliferative Disease 9 60
Myeloid Neoplasm 9 60
Myeloproliferative Disease, No Icd-O Subtype 9
 
Chronic Myeloproliferative Disorder 60
Myeloproliferative Disease, Nos 9
Myeloproliferative Disease Nos 9
Malignant Bone Marrow Tumor 9
Myeloproliferative Tumors 9
Neoplasm of Bone Marrow 9
Bone Marrow Neoplasms 60
Bone Marrow Neoplasm 9
Bone Marrow Tumor 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:4960
MeSH33 D009196
UMLS60 C002702

Related Diseases for Bone Marrow Cancer

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Diseases related to Bone Marrow Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1precursor b-cell acute lymphoblastic leukemia30.2FLT3, ABL1
2myeloid leukemia30.1FLT3, ABL1
3acute leukemia30.0ABL1, FLT3, KRAS
4chronic lymphocytic leukemia30.0ABL1, FLT3
5leukemia30.0KRAS, NRAS, FLT3, ABL1
6leukemia, juvenile myelomonocytic29.7KRAS, NRAS, FLT3
7myelodysplastic syndrome29.4ABL1, FLT3, NRAS, KRAS
8melanoma29.4KRAS, NRAS, FLT3, ABL1
9leukemia, chronic myeloid29.3ABL1, FLT3, NRAS, KRAS
10breast cancer29.3KRAS, NRAS, FLT3, ABL1
11down syndrome10.9
12myeloproliferative disorder with eosinophilia10.5
13eosinophilia10.5
14thrombocytosis10.5
15essential thrombocythemia10.5
16hepatitis10.4
17chronic myeloproliferative disease10.4
18cerebritis10.4
19budd-chiari syndrome10.3
20chronic myelomonocytic leukemia10.3
21lymphoblastic lymphoma10.3
22portal vein thrombosis10.3
23endotheliitis10.3
24erythromelalgia10.3
25hepatic vein thrombosis10.2
26hypereosinophilic syndrome10.2
27pdgfrb-associated chronic eosinophilic leukemia10.2
28myeloid neoplasm associated with fgfr1 rearrangement10.2
29myeloid neoplasm associated with pdgfrb rearrangement10.2
30myeloid neoplasm associated with pdgfra rearrangement10.2
31systemic mastocytosis10.2
32portal hypertension10.2
33mastocytosis10.2
34splenomegaly10.2
35refractory anemia10.2
36unclassified myelodysplastic/myeloproliferative disease10.2
37thrombocythemia 110.2
38hemorrhagic thrombocythemia10.2
39vasculitis10.2
40hydrops fetalis10.2
41thyroid cancer10.1ABL1, FLT3
42hemarthrosis10.1
43gastrointestinal stromal tumor10.1FLT3, ABL1
44myelodysplastic myeloproliferative cancer10.1
45myelofibrosis10.1
46myeloma10.1
47papular mucinosis10.1
48leukemia, acute promyelocytic10.1NRAS, FLT3
49factor v deficiency10.1
50myeloperoxidase deficiency10.1

Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Symptoms for Bone Marrow Cancer

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Drugs & Therapeutics for Bone Marrow Cancer

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Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Bone Marrow Cancer

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Genetic tests related to Bone Marrow Cancer:

id Genetic test Affiliating Genes
1 Myeloproliferative Disorder22

Anatomical Context for Bone Marrow Cancer

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MalaCards organs/tissues related to Bone Marrow Cancer:

31
Bone marrow, Bone, Myeloid

Animal Models for Bone Marrow Cancer or affiliated genes

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MGI Mouse Phenotypes related to Bone Marrow Cancer:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7KRAS, NRAS, ABL1
2MP:00020068.7KRAS, NRAS, FLT3
3MP:00053818.6ABL1, NRAS, KRAS
4MP:00053808.6KRAS, NRAS, ABL1
5MP:00053918.3KRAS, NRAS, ABL1
6MP:00053978.2KRAS, NRAS, FLT3, ABL1
7MP:00053878.2ABL1, FLT3, NRAS, KRAS
8MP:00053848.2ABL1, FLT3, NRAS, KRAS
9MP:00053788.2ABL1, FLT3, NRAS, KRAS
10MP:00053768.1ABL1, FLT3, NRAS, KRAS
11MP:00107687.9ABL1, FLT3, NRAS, KRAS

Publications for Bone Marrow Cancer

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Articles related to Bone Marrow Cancer:

idTitleAuthorsYear
1
Mayo breakthrough: virus may destroy bone marrow cancer. (25233543)
2014
2
Erythrokinetics and androgens in bone marrow cancer. (975001)
1976

Variations for Bone Marrow Cancer

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Expression for genes affiliated with Bone Marrow Cancer

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Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

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Pathways related to Bone Marrow Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3NRAS, FLT3
29.3ABL1, FLT3
3
Show member pathways
Signal transduction cAMP signaling58
9.1KRAS, NRAS
4
Show member pathways
9.1NRAS, KRAS
59.1KRAS, NRAS
6
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.1NRAS, KRAS
7
Show member pathways
9.1NRAS, KRAS
8
Show member pathways
9.1NRAS, KRAS
99.1KRAS, NRAS
10
Show member pathways
9.1KRAS, NRAS
119.1NRAS, KRAS
129.1NRAS, KRAS
13
Show member pathways
Signaling Pathways in Glioblastoma36
9.1KRAS, NRAS
14
Show member pathways
Immune response CD16 signaling in NK cells58
9.1KRAS, NRAS
15
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.1KRAS, NRAS
169.1KRAS, NRAS
17
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1KRAS, NRAS
189.1NRAS, KRAS
19
Show member pathways
9.1KRAS, NRAS
20
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.1NRAS, KRAS
21
Show member pathways
9.1KRAS, NRAS
22
Show member pathways
9.1KRAS, NRAS
23
Show member pathways
9.1KRAS, NRAS
24
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.1KRAS, NRAS
25
Show member pathways
9.1KRAS, NRAS
26
Show member pathways
9.1KRAS, NRAS
27
Show member pathways
9.1KRAS, NRAS
289.1KRAS, NRAS
29
Show member pathways
EGFR-dependent Endothelin signaling events36
9.1KRAS, NRAS
309.1KRAS, NRAS
319.1KRAS, NRAS
32
Show member pathways
9.1KRAS, NRAS
33
Show member pathways
9.1NRAS, KRAS
34
Show member pathways
9.1NRAS, KRAS
35
Show member pathways
9.1KRAS, NRAS
369.1NRAS, KRAS
379.1ABL1, KRAS
389.1KRAS, ABL1
39
Show member pathways
8.8NRAS, FLT3, ABL1
408.6KRAS, NRAS, ABL1
41
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.6KRAS, NRAS, ABL1
42
Show member pathways
8.6ABL1, NRAS, KRAS
43
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.6ABL1, NRAS, KRAS
44
Show member pathways
8.6ABL1, NRAS, KRAS
45
Show member pathways
8.6KRAS, NRAS, ABL1
46
Show member pathways
8.6ABL1, NRAS, KRAS
478.6ABL1, NRAS, KRAS
48
Show member pathways
Signal transduction PTEN pathway58
8.5FLT3, NRAS, KRAS
49
Show member pathways
8.5KRAS, NRAS, FLT3
508.0KRAS, NRAS, FLT3, ABL1

Compounds for genes affiliated with Bone Marrow Cancer

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Compounds related to Bone Marrow Cancer according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ponatinib49 1210.6ABL1, FLT3
2agar439.4ABL1, NRAS
3nucleoside439.4FLT3, ABL1
4regorafenib49 1210.3KRAS, ABL1
5cytarabine43 49 1211.2ABL1, FLT3
6herbimycin a43 5910.0FLT3, ABL1
7imatinib43 49 1210.8ABL1, FLT3, KRAS
8phosphoinositide438.7FLT3, ABL1, KRAS
9vegf438.7FLT3, ABL1, KRAS
10phosphatidylinositol438.6FLT3, KRAS, ABL1
11retinoic acid43 249.5FLT3, ABL1, KRAS
12oligonucleotide438.3ABL1, FLT3, NRAS, KRAS
13tyrosine438.2ABL1, FLT3, NRAS, KRAS

GO Terms for genes affiliated with Bone Marrow Cancer

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Biological processes related to Bone Marrow Cancer according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:00181089.5FLT3, ABL1
2positive regulation of Rac protein signal transductionGO:00350229.5KRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:00322289.5NRAS, KRAS
4striated muscle cell differentiationGO:00511469.5KRAS, NRAS
5regulation of long-term neuronal synaptic plasticityGO:00481699.5KRAS, NRAS
6visual learningGO:00085429.4KRAS, NRAS
7activation of MAPKK activityGO:00001869.4NRAS, KRAS
8MAPK cascadeGO:00001659.4KRAS, NRAS
9Ras protein signal transductionGO:00072659.4NRAS, KRAS
10positive regulation of MAP kinase activityGO:00434069.3KRAS, FLT3
11leukocyte migrationGO:00509009.3KRAS, NRAS
12negative regulation of neuron apoptotic processGO:00435249.3NRAS, KRAS
13GTP catabolic processGO:00061849.2KRAS, NRAS
14insulin receptor signaling pathwayGO:00082869.2KRAS, NRAS
15fibroblast growth factor receptor signaling pathwayGO:00085439.1NRAS, KRAS
16Fc-epsilon receptor signaling pathwayGO:00380959.0KRAS, NRAS
17cytokine-mediated signaling pathwayGO:00192219.0KRAS, FLT3
18actin cytoskeleton organizationGO:00300369.0KRAS, NRAS, ABL1
19axon guidanceGO:00074118.9ABL1, NRAS, KRAS
20blood coagulationGO:00075968.9ABL1, NRAS, KRAS
21innate immune responseGO:00450878.9KRAS, NRAS, ABL1
22epidermal growth factor receptor signaling pathwayGO:00071738.8KRAS, NRAS
23positive regulation of cell proliferationGO:00082848.8KRAS, NRAS, FLT3

Molecular functions related to Bone Marrow Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.1KRAS, NRAS

Products for genes affiliated with Bone Marrow Cancer

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Bone Marrow Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet