MCID: BNM001
MIFTS: 36

Bone Marrow Cancer malady

Bone diseases, Immune diseases, Cancer diseases categories

Summaries for Bone Marrow Cancer

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63Wikipedia, 32MalaCards
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Wikipedia:63 Multiple myeloma (from Greek myelo-, marrow), also known as plasma cell myeloma or Kahler\'s disease... more...

MalaCards: Bone Marrow Cancer, also known as bone marrow neoplasms, is related to myeloma and myelodysplastic myeloproliferative cancer. An important gene associated with Bone Marrow Cancer is NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog), and among its related pathways are SHC1 events in ERBB2 signaling and ARMS-mediated activation. The compounds daniplestim and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and kidney, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Bone Marrow Cancer

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10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Immune diseases


Aliases & Descriptions:

bone marrow cancer 10
bone marrow neoplasms 60


Related Diseases for Bone Marrow Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Bone Marrow Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.0BCR, IL3
2myelodysplastic myeloproliferative cancer10.0
3papular mucinosis10.0
4polycythemia10.0IL3
5eosinophilia10.0IL3
6mastocytosis10.0KIT
7adenocarcinoma10.0KRAS
8chronic myeloproliferative disease10.0FLT3
9hepatitis10.0KRAS
10testicular cancer10.0KRAS
11uterine sarcoma10.0KIT
12rhabdoid tumor10.0BCR
13germ cell tumors10.0KIT
14astrocytoma10.0BCR
15dermatofibrosarcoma protuberans10.0KIT
16severe combined immunodeficiency10.0IL3, FLT3
17myelofibrosis10.0IL3, KIT
18thyroid cancer10.0ABL1, FLT3
19hypereosinophilic syndrome10.0IL3, KIT
20pancreatitis10.0KRAS, NRAS
21colorectal cancer10.0KRAS, NRAS
22pancreatic cancer10.0KRAS, NRAS
23hairy cell leukemia10.0IL3, FLT3
24hemorrhagic thrombocythemia10.0KIT, IL3
25myeloid sarcoma10.0FLT3, KIT
26acute myeloid leukemia10.0KIT, FLT3
27exanthem10.0KRAS, NRAS
28acute myeloid leukemia, adult10.0FLT3, KIT
29lung cancer10.0KRAS, NRAS
30glioblastoma multiforme10.0ABL1, KIT
31cholangiocarcinoma10.0NRAS, KRAS
32acute promyelocytic leukemia10.0IL3, NRAS, FLT3
33malignant mixed mullerian tumor10.0KRAS, KIT
34polycythemia vera10.0KIT, IL3, FLT3
35refractory anemia10.0FLT3, IL3, KIT
36mast cell neoplasm10.0FLT3, IL3, KIT
37colon cancer10.0KRAS, ABL1
38deficiency anemia10.0FLT3, IL3, ABL1
39wilms tumor10.0ABL1, FLT3
40juvenile myelomonocytic leukemia10.0KRAS, NRAS, FLT3
41factor vii deficiency10.0KRAS, KIT
42sarcoma10.0KRAS, KIT, NRAS
43aplastic anemia10.0IL3, FLT3
44neurofibromatosis10.0KIT, KRAS
45lung small cell carcinoma10.0IL3, KIT, KRAS
46hodgkin's lymphoma10.0FLT3, IL3, BCR
47chronic myelomonocytic leukemia10.0FLT3, KIT, BCR
48chronic lymphocytic leukemia10.0BCR, ABL1, FLT3
49non-hodgkin lymphoma10.0FLT3, ZMYM2, IL3, BCR
50retinoblastoma10.0BCR, KRAS, ABL1

Graphical network of the top 20 diseases related to Bone Marrow Cancer:



Diseases related to bone marrow cancer

Clinical Features for Bone Marrow Cancer

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Drugs & Therapeutics for Bone Marrow Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bone Marrow Cancer

Drug clinical trials:

Search ClinicalTrials for Bone Marrow Cancer

Search NIH Clinical Center for Bone Marrow Cancer

Search CenterWatch for Bone Marrow Cancer

Genetic Tests for Bone Marrow Cancer

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Anatomical Context for Bone Marrow Cancer

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32MalaCards
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MalaCards organs/tissues related to Bone Marrow Cancer:

32
Bone marrow, Bone, Kidney

Animal Models for Bone Marrow Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bone Marrow Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6FLT3, NRAS, IL3, KIT, KRAS
2MP:00053708.1NRAS, ABL1, KIT, KRAS, BCR
3MP:00053817.9NRAS, ABL1, KIT, KRAS, BCR
4MP:00053787.6BCR, KRAS, KIT, ABL1, NRAS, FLT3
5MP:00053977.5BCR, FLT3, NRAS, IL3, ABL1, KIT
6MP:00053877.5FLT3, NRAS, IL3, ABL1, KIT, KRAS
7MP:00053847.4FLT3, NRAS, IL3, ABL1, KIT, KRAS
8MP:00053767.3FLT3, NRAS, IL3, ABL1, KIT, KRAS
9MP:00107687.0FLT3, NRAS, IL3, ABL1, KIT, KRAS

Publications for Bone Marrow Cancer

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Genetic Variations for Bone Marrow Cancer

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Expression for genes affiliated with Bone Marrow Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Marrow Cancer

Search GEO for disease gene expression data for Bone Marrow Cancer.

Pathways for genes affiliated with Bone Marrow Cancer

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Sources:
53Reactome, 29KEGG, 49PharmGKB, 51QIAGEN, 59Tocris Bioscience, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6NRAS, KRAS
2
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9.6KRAS, NRAS
39.6KRAS, NRAS
4
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9.6KRAS, NRAS
5
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9.6NRAS, KRAS
69.6NRAS, KRAS
79.6KRAS, NRAS
8
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9.4IL3, NRAS, FLT3
9
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9.4BCR, KIT
10
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9.3KIT, NRAS, FLT3
11
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9.3KRAS, IL3, NRAS
12
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9.3KRAS, IL3, NRAS
13
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9.3NRAS, IL3, KRAS
149.3FLT3, IL3, KIT
15
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9.2KRAS, KIT, NRAS
16
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9.2KRAS, KIT, NRAS
17
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9.2KRAS, KIT, NRAS
18
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9.2KRAS, KIT, NRAS
19
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9.2NRAS, KIT, KRAS
209.1KRAS, ABL1, NRAS
21
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9.1NRAS, ABL1, KRAS
229.1NRAS, ABL1, KRAS
23
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9.1NRAS, ABL1, KRAS
249.1IL3, ABL1, KRAS
25
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8.9KIT, IL3, NRAS, FLT3
26
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8.9KIT, IL3, NRAS, FLT3
27
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8.9FLT3, NRAS, IL3, KIT
28
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8.9KIT, IL3, NRAS, FLT3
29
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8.9KIT, IL3, NRAS, FLT3
30
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8.9FLT3, NRAS, IL3, KIT
318.8NRAS, IL3, KIT, KRAS
32
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8.8KIT, ABL1, IL3, NRAS
33
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8.8FLT3, NRAS, KIT, KRAS
34
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8.6ZMYM2, NRAS, KRAS, BCR
35
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8.5BCR, KRAS, ABL1, NRAS
368.5BCR, KIT, ABL1, FLT3
37
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8.4KIT, ABL1, IL3, NRAS, FLT3
38
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8.2ZMYM2, NRAS, KIT, KRAS, BCR
398.2ZMYM2, NRAS, KIT, KRAS, BCR
407.6BCR, KRAS, KIT, ABL1, NRAS, FLT3

Compounds for genes affiliated with Bone Marrow Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1daniplestim4410.1FLT3, IL3
2pixy3214410.1FLT3, IL3
3idarubicin44 49 1112.0IL3, FLT3
4tandutinib4410.0KIT, FLT3
5rhodamine 12344 4911.0KIT, IL3
6pkc 4124410.0KIT, FLT3
7su5416449.9KIT, FLT3
8sunitinib44 49 1111.9KIT, FLT3
9nilotinib49 1110.9KIT, ABL1
10Regorafenib119.8ABL1, KIT
11fluorochrome449.7KIT, BCR
12ag-1296449.7KIT, IL3, FLT3
1317-(allylamino)-17-demethoxygeldanamycin449.7KIT, FLT3
14methylcellulose449.7KIT, IL3, FLT3
15leucovorin44 49 1111.6KRAS, IL3
16adp44 28 2411.6BCR, FLT3
17herbimycin a44 5910.5FLT3, IL3, ABL1
18paclitaxel44 49 1111.5KRAS, IL3
19Ponatinib 119.5FLT3, ABL1, KIT
20agar449.5NRAS, IL3, ABL1
21valine449.5KRAS, KIT, IL3
225fluorouracil449.4KRAS, KIT, IL3
23dasatinib44 49 1111.3ABL1, KIT, BCR
24erlotinib44 49 1111.2KRAS, KIT
25rapamycin449.1KRAS, KIT, IL3, FLT3
26phenylalanine449.1ABL1, KIT, BCR
27gp 130449.1FLT3, IL3, KIT, BCR
28thymidine44 2410.0BCR, KIT, IL3, FLT3
29h2o2448.8IL3, ABL1, KRAS, BCR
30vegf448.7KRAS, KIT, ABL1, FLT3
31retinoic acid44 249.6FLT3, IL3, ABL1, KIT, KRAS
32cytarabine44 49 1110.5FLT3, IL3, ABL1, KIT, BCR
33phosphotyrosine448.5FLT3, IL3, ABL1, KIT, BCR
34threonine448.5FLT3, IL3, ABL1, KIT, BCR
35Adenosine triphosphate11 249.5FLT3, ABL1, KIT, BCR
36phosphoinositide448.3BCR, KRAS, KIT, ABL1, FLT3
37serine448.2IL3, ABL1, KIT, KRAS, BCR
38oligonucleotide448.0FLT3, NRAS, ABL1, KIT, KRAS, BCR
39imatinib44 49 1110.0BCR, KRAS, KIT, ABL1, IL3, FLT3
40phosphatidylinositol448.0BCR, KRAS, KIT, ABL1, IL3, FLT3
41tyrosine447.3FLT3, ZMYM2, NRAS, IL3, ABL1, KIT

GO Terms for genes affiliated with Bone Marrow Cancer

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16Gene Ontology
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Biological processes related to Bone Marrow Cancer according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0KIT, IL3
2positive regulation of Rac protein signal transductionGO:03502210.0KRAS, NRAS
3regulation of synaptic transmission, GABAergicGO:03222810.0KRAS, NRAS
4striated muscle cell differentiationGO:05114610.0KRAS, NRAS
5embryonic hemopoiesisGO:03516210.0IL3, KIT
6myeloid progenitor cell differentiationGO:00231810.0FLT3, KIT
7regulation of long-term neuronal synaptic plasticityGO:0481699.9KRAS, NRAS
8positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8KIT, FLT3
9visual learningGO:0085429.7KRAS, NRAS
10positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.6FLT3, KIT
11positive regulation of MAP kinase activityGO:0434069.6KRAS, FLT3
12activation of MAPKK activityGO:0001869.5KRAS, NRAS
13platelet-derived growth factor receptor signaling pathwayGO:0480089.5BCR, ABL1
14fibroblast growth factor receptor signaling pathwayGO:0085439.5KRAS, KIT, NRAS
15peptidyl-tyrosine phosphorylationGO:0181089.4FLT3, ABL1, KIT
16Fc-epsilon receptor signaling pathwayGO:0380959.4KRAS, KIT, NRAS
17epidermal growth factor receptor signaling pathwayGO:0071739.4NRAS, KIT, KRAS
18neurotrophin TRK receptor signaling pathwayGO:0480119.3KRAS, KIT, NRAS
19protein autophosphorylationGO:0467779.3FLT3, KIT, BCR
20cytokine-mediated signaling pathwayGO:0192219.3FLT3, KIT, KRAS
21hemopoiesisGO:0300979.1KIT, CD164, FLT3
22small GTPase mediated signal transductionGO:0072649.0BCR, KRAS, NRAS
23innate immune responseGO:0450878.9KRAS, KIT, ABL1, NRAS
24actin cytoskeleton organizationGO:0300368.9BCR, KRAS, ABL1, NRAS
25axon guidanceGO:0074118.8KRAS, ABL1, NRAS
26positive regulation of cell proliferationGO:0082848.8FLT3, NRAS, IL3, KIT, KRAS

Molecular functions related to Bone Marrow Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, FLT3
2protein tyrosine kinase activityGO:0047138.6BCR, KIT, ABL1

Products for genes affiliated with Bone Marrow Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bone Marrow Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet