MCID: BNS001
MIFTS: 38

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Osteosarcoma

MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 14
Osteosarcoma of Bone 12 69
Primary Osteosarcoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3376
NCIt 46 C53707
SNOMED-CT 64 307576001
UMLS 69 C0585442

Summaries for Bone Osteosarcoma

MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to osteogenic sarcoma and malignant fibrous histiocytoma of bone. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 Homeobox 2), and among its related pathways/superpathways are Bladder cancer and Integrated Cancer Pathway. The drugs Radium Ra 223 dichloride and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotype is limbs/digits/tail.

Related Diseases for Bone Osteosarcoma

Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 31.9 CDK4 MDM2 SPARC
2 malignant fibrous histiocytoma of bone 30.2 CDK4 MDM2
3 primary bone cancer 11.0
4 ring chromosome 7 10.3 CDK4 MDM2
5 undifferentiated embryonal sarcoma of the liver 10.3 CDK4 MDM2
6 infiltrating angiolipoma 10.3 CDK4 MDM2
7 spindle cell lipoma 10.3 CDK4 MDM2
8 extraosseous osteosarcoma 10.3 CDK4 MDM2
9 inflammatory mfh 10.3 CDK4 MDM2
10 lipoblastoma 10.3 CDK4 MDM2
11 mixed liposarcoma 10.3 CDK4 MDM2
12 ischemic fasciitis 10.3 CDK4 MDM2
13 periosteal chondrosarcoma 10.3 CDK4 MDM2
14 atypical lipomatous tumor 10.3 CDK4 MDM2
15 spindle cell liposarcoma 10.3 CDK4 MDM2
16 well-differentiated liposarcoma 10.3 CDK4 MDM2
17 chondroid lipoma 10.3 CDK4 MDM2
18 dedifferentiated liposarcoma 10.3 CDK4 MDM2
19 infiltrating lipoma 10.3 CDK4 MDM2
20 pleomorphic lipoma 10.2 CDK4 MDM2
21 small cell sarcoma 10.2 CDK4 MDM2
22 embryonal sarcoma 10.2 CDK4 MDM2
23 lipomatosis, multiple 10.2 CDK4 MDM2
24 malignant fibroxanthoma 10.2 CDK4 MDM2
25 fibrosarcoma of bone 10.2 CDK4 MDM2
26 malignant mesenchymoma 10.2 CDK4 MDM2
27 retinal cancer 10.2 CDK4 MDM2
28 grade iii astrocytoma 10.2 CDK4 MDM2
29 sensory system cancer 10.2 CDK4 MDM2
30 connective tissue cancer 10.2 CDK4 MDM2
31 myxoid liposarcoma 10.1 CDK4 MDM2
32 ocular cancer 10.1 CDK4 MDM2
33 histiocytoma 10.1 CDK4 MDM2
34 rhabdomyosarcoma 2 10.1 CDK4 MDM2
35 leiomyosarcoma 10.0 CDK4 MDM2
36 nervous system cancer 9.9 CDK4 MDM2
37 liposarcoma 9.8 CDK4 MDM2
38 chondrosarcoma 9.6
39 aging 9.6
40 glass syndrome 9.6
41 giant cell tumor 9.6
42 malignant giant cell tumor 9.6
43 fibrosarcoma 9.6
44 paget's disease of bone 9.6
45 enchondroma 9.6
46 juxtacortical osteosarcoma 9.6 CDK4 EMILIN1 MDM2 SATB2
47 conventional central osteosarcoma 9.4 CYP4V2 MDM2 RFC2 SATB2
48 periosteal osteogenic sarcoma 9.4 CDK4 MDM2 SATB2 SPARC
49 peripheral osteosarcoma 9.0 CDK4 EMILIN1 MDM2 SATB2 SPARC

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma

Symptoms & Phenotypes for Bone Osteosarcoma

MGI Mouse Phenotypes related to Bone Osteosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 MDM2 NKX3-2 SATB2 SPARC

Drugs & Therapeutics for Bone Osteosarcoma

Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 329)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 1,Phase 2 444811-40-9
2
Dalteparin Approved Phase 4 9005-49-6
3
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
4
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
5 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
6 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
7 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
9 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
12 Cyclooxygenase Inhibitors Phase 4,Phase 2
13 Antidepressive Agents Phase 4
14 Antimanic Agents Phase 4,Phase 1
15 Lithium carbonate Phase 4 554-13-2
16 Psychotropic Drugs Phase 4,Phase 1
17 Tranquilizing Agents Phase 4,Phase 1
18 Anticoagulants Phase 4
19 calcium heparin Phase 4
20 Fibrinolytic Agents Phase 4
21 Heparin, Low-Molecular-Weight Phase 4
22 Antipyretics Phase 4
23 Platelet Aggregation Inhibitors Phase 4
24
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 2767 441203 84093
25
Doxorubicin Approved, Investigational Phase 2, Phase 3, Phase 1 23214-92-8 31703
26
Ifosfamide Approved Phase 2, Phase 3, Phase 1 3778-73-2 3690
27
Zoledronic acid Approved Phase 2, Phase 3, Phase 1 118072-93-8 68740
28
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 50-02-2 5743
29
Diphenhydramine Approved, Investigational Phase 2, Phase 3 58-73-1, 147-24-0 3100
30
Gemcitabine Approved Phase 2, Phase 3,Phase 1 95058-81-4 60750
31
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
32
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
33
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
34
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
35
Mesna Approved, Investigational Phase 3,Phase 2,Phase 1 3375-50-6 598
36
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
37
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1 55-98-1 2478
38
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
39
Melphalan Approved Phase 3,Phase 2,Phase 1 148-82-3 460612 4053
40
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
41
Everolimus Approved Phase 3,Phase 2,Phase 1 159351-69-6 6442177
42
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
43
Sirolimus Approved, Investigational Phase 3,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
44
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
45
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
47
Sorafenib Approved, Investigational Phase 2, Phase 3,Phase 1 284461-73-0 216239 406563
48
Topotecan Approved, Investigational Phase 3,Phase 2,Phase 1 119413-54-6, 123948-87-8 60700
49
Cefazolin Approved Phase 3 25953-19-9 33255 656510
50
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676

Interventional clinical trials:

(show top 50) (show all 434)

# Name Status NCT ID Phase Drugs
1 Physical Characteristics of Retrieved Massive Allografts Completed NCT00160758 Phase 4
2 HLA Sensitization Following Major Cortical Allograft Bone Procedures Completed NCT00160719 Phase 4
3 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
4 Radium-223 Dichloride Long-term Follow-up Program Active, not recruiting NCT02312960 Phase 4
5 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Not yet recruiting NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
6 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
7 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
8 Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma Unknown status NCT01091883 Phase 3
9 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
11 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
12 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
13 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
14 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
15 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
16 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
17 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
18 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
19 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
20 ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Metastatic Bone Tumors for the Palliation of Pain Completed NCT00656305 Phase 3
21 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
22 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
23 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
24 ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma Recruiting NCT01459484 Phase 2, Phase 3 Mifamurtide arm
25 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Recruiting NCT02711007 Phase 2, Phase 3 apatinib
26 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Recruiting NCT01479283 Phase 3 24-Hour Prophylactic Cefazolin* Antibiotic Regimen;5-Days Prophylactic Cefazolin* Antibiotic Regimen
27 Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer Recruiting NCT01916317 Phase 3 0.5% lignocaine 60mM
28 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
29 Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Recruiting NCT02063022 Phase 3 Standard treatment (as per protocol ISG SSG III);Intensified chemotherapy
30 Study in Localized and Disseminated Ewing Sarcoma Recruiting NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
31 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
32 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 doxorubicin hydrochloride;cisplatin;methotrexate;ifosfamide;etoposide
33 Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Active, not recruiting NCT02856048 Phase 2, Phase 3 Triptorelin (GnRHa) + Chemotherapy
34 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
35 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3 vincristine sulfate;doxorubicin hydrochloride;cyclophosphamide;ifosfamide;etoposide;topotecan hydrochloride
36 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
37 Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia Terminated NCT00127387 Phase 2, Phase 3 Enbrel
38 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
39 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
40 Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients Withdrawn NCT01734863 Phase 3
41 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
42 Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma Unknown status NCT01216826 Phase 2 Everolimus
43 A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma Unknown status NCT01002092 Phase 2 Chemotherapy;Endostar
44 Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma Unknown status NCT00689195 Phase 1, Phase 2
45 Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity Unknown status NCT02273583 Phase 2 continuous oral cyclophosphamide and methotrexate
46 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
47 The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells Unknown status NCT01868490 Phase 1, Phase 2 cytokine induced killer cells
48 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
49 Study of Intensive Chemotherapy, Surgery and Radiotherapy to Treat Ewing's Sarcoma in Children and Young Adults Unknown status NCT01696669 Phase 2 Chemotherapy
50 Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas Unknown status NCT00998361 Phase 2

Search NIH Clinical Center for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

Anatomical Context for Bone Osteosarcoma

MalaCards organs/tissues related to Bone Osteosarcoma:

38
Bone, Lung, T Cells, Testes, Brain, Nk Cells, Breast

Publications for Bone Osteosarcoma

Articles related to Bone Osteosarcoma:

# Title Authors Year
1
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. ( 28152478 )
2017
2
Orbital metastasis: a rare manifestation of scapular bone osteosarcoma. ( 25709781 )
2014
3
Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. ( 21207222 )
2011
4
Primary bone osteosarcoma in the pediatric age: state of the art. ( 16860938 )
2006
5
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding. ( 7976302 )
1994
6
Problems and pitfalls in the use of computed tomography for the local evaluation of long bone osteosarcoma: report on 30 cases. ( 3856325 )
1985
7
Computed tomography of long-bone osteosarcoma. ( 286376 )
1979
8
Long bone osteosarcoma in a rhesus monkey. ( 293317 )
1979
9
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). ( 5272232 )
1970

Variations for Bone Osteosarcoma

Expression for Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for Bone Osteosarcoma

Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.12 CDK4 MDM2
2 10.82 CDK4 MDM2
3 10.6 CDK4 MDM2
4 10.13 CDK4 MDM2

GO Terms for Bone Osteosarcoma

Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.37 MDM2 SPARC
2 regulation of gene expression GO:0010468 9.33 CDK4 MDM2 SATB2
3 positive regulation of cell cycle GO:0045787 9.32 CDK4 MDM2
4 cellular response to organic substance GO:0071310 9.26 MDM2 SATB2
5 negative regulation of cell cycle arrest GO:0071157 8.96 CDK4 MDM2
6 response to lead ion GO:0010288 8.62 CDK4 SPARC

Sources for Bone Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....