MCID: BNS001
MIFTS: 28

Bone Osteosarcoma malady

Bone category

Summaries for Bone Osteosarcoma

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33MalaCards
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MalaCards: Bone Osteosarcoma, also known as osteosarcoma of bone, is related to fibrous dysplasia and osteopoikilosis. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 homeobox 2). Affiliated tissues include bone marrow, kidney and liver, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Aliases & Classifications for Bone Osteosarcoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

bone osteosarcoma 8
osteosarcoma of bone 8 61
primary osteosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3376
SNOMED-CT57 307576001
NCIt40 C53707

Related Diseases for Bone Osteosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fibrous dysplasia10.1
2osteopoikilosis10.0
3bone giant cell tumor10.0
4osteosarcoma10.0TNFRSF11A

Clinical Features for Bone Osteosarcoma

Drugs & Therapeutics for Bone Osteosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bone Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Bone Osteosarcoma

Search NIH Clinical Center for Bone Osteosarcoma

Search CenterWatch for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

Anatomical Context for Bone Osteosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Bone Osteosarcoma:

33
Bone marrow, Kidney, Liver, Prostate, T cells, B cells

Animal Models for Bone Osteosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Bone Osteosarcoma

Sources:
51PubMed
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Articles related to Bone Osteosarcoma:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005. (24425828)
2014
2
Bone morphogenetic protein 9 regulates tumor growth of osteosarcoma cells through the Wnt/I^-catenin pathway. (24337584)
2014
3
Association between absolute tumor burden and serum bone-specific alkaline phosphatase in canine appendicular osteosarcoma. (23734720)
2013
4
Increased invasiveness of osteosarcoma mesenchymal stem cells induced by bone-morphogenetic protein-2. (23519562)
2013
5
Bone formation induced by BMP-2 in human osteosarcoma cells. (23900689)
2013
6
Osteosarcoma pulmonary metastasis mimicking abnormal skeletal uptake in bone scan: utility of SPECT/CT. (23486324)
2013
7
Osteosarcoma After Bone Marrow Transplantation: Still a Challenge. (23929319)
2013
8
Radiographically Occult Latent Radiogenic Osteosarcoma Uncovered on Tc-99m Methylene-diphosphonate Bone Scintigraphy. (24228214)
2013
9
Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice. (22550000)
2012
10
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. (21336260)
2011
11
Malignant pleural mesothelioma with osteosarcomatous differentiation: characteristic bone scintigraphy findings associated with enhanced tumorous osteogenesis. (21130666)
2011
12
Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma. (20090505)
2010
13
Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. (19596932)
2009
14
Bone biology and physiology: implications for novel osteoblastic osteosarcoma treatments? (17683874)
2008
15
Long bone florid reactive periostitis ossificans: a case in the distal femur mimicking osteosarcoma. (18841064)
2008
16
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. (17671200)
2007
17
Expression of cyclooxygenase-2 in osteosarcoma of bone. (17536311)
2007
18
Primary bone osteosarcoma in the pediatric age: state of the art. (16860938)
2006
19
Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium. (16674304)
2006
20
Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. (16475708)
2006
21
Osteosarcoma in Paget's disease of bone. (17229010)
2006
22
Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. (16087680)
2005
23
An unusual case of juxtacortical osteosarcoma presenting on Tc-99m MDP bone scan with central photopenia. (14734911)
2004
24
A fatal case of pleural osteosarcoma mimicking mesothelioma in Paget's disease of bone. (14645873)
2003
25
ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. (12569382)
2003
26
A rare tumor of craniofacial bones in children: a pediatric chondroblastic osteosarcoma case with diagnostic and therapeutic problems. (11255734)
2001
27
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. (11351498)
2001
28
Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. (11797833)
2001
29
Gsalpha gene mutations in monostotic fibrous dysplasia of bone and fibrous dysplasia-like low-grade central osteosarcoma. (11561757)
2001
30
The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures. (10716620)
2000
31
Expression of bone morphogenetic protein and its receptors in osteosarcoma and malignant fibrous histiocytoma. (10939432)
2000
32
Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. (10977962)
2000
33
Neoadjuvant chemotherapy with doxorubicin and cisplatin in malignant fibrous histiocytoma of bone: A European Osteosarcoma Intergroup study. (10506628)
1999
34
1,25-Dihydroxyvitamin D3, recombinant human transforming growth factor-beta 1, and recombinant human bone morphogenetic protein-2 induce in vitro differentiation of canine osteosarcoma cells. (10423687)
1999
35
Purification and characterization of bone-specific alkaline phosphatase from a human osteosarcoma cell line. (9405736)
1998
36
P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. (9228255)
1997
37
Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone. (18521214)
1997
38
Low rates of Paget's disease of bone and osteosarcoma in elderly Japanese. (8684133)
1996
39
1,25-Dihydroxyvitamin D3 and transforming growth factor-beta act synergistically to override extinction of liver/bone/kidney alkaline phosphatase in osteosarcoma hybrid cells. (8682172)
1996
40
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. (8625223)
1995
41
The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. (7641470)
1995
42
Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. (7826985)
1994
43
Picomolar norethindrone in vitro stimulates the cell proliferation and activity of a human osteosarcoma cell line and increases bone collagen synthesis without an effect on bone resorption. (8053399)
1994
44
Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. (7506120)
1994
45
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. (7503935)
1993
46
Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. (8418091)
1993
47
Purification and partial identification of bone-inducing protein from a murine osteosarcoma. (1320380)
1992
48
Detection of bone-type alkaline phosphatase by monoclonal antibodies reacting with human osteosarcoma-associated antigen. (1715340)
1991
49
Identification of a bone sialoprotein receptor in osteosarcoma cells. (2461939)
1988
50
Computed tomography of long-bone osteosarcoma. (286376)
1979

Genetic Variations for Bone Osteosarcoma

Expression for genes affiliated with Bone Osteosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for genes affiliated with Bone Osteosarcoma

Compounds for genes affiliated with Bone Osteosarcoma

GO Terms for genes affiliated with Bone Osteosarcoma

Sources:
16Gene Ontology
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Biological processes related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of chondrocyte differentiationGO:0323319.0NKX3-2, SNAI2

Molecular functions related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0NKX3-2, SNAI2

Products for genes affiliated with Bone Osteosarcoma

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Sources for Bone Osteosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet