MCID: BNS001
MIFTS: 31

Bone Osteosarcoma malady

Bone diseases category

Summaries for Bone Osteosarcoma

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32MalaCards
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MalaCards: Bone Osteosarcoma, also known as osteosarcoma of bone, is related to osteosarcoma and paget's disease of bone. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 homeobox 2). Affiliated tissues include bone, liver and kidney, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Aliases & Classifications for Bone Osteosarcoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone osteosarcoma 8
osteosarcoma of bone 8 60
primary osteosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3376
SNOMED-CT56 307576001
NCIt39 C53707

Related Diseases for Bone Osteosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.5TNFRSF11A
2paget's disease of bone10.1
3fibrous dysplasia10.0
4localized osteosarcoma10.0
5osteopoikilosis10.0
6bone giant cell tumor10.0
7chondrosarcoma10.0
8fibrosarcoma10.0
9giant cell tumor10.0
10malignant giant cell tumor10.0
11pediatric osteosarcoma10.0

Graphical network of diseases related to Bone Osteosarcoma:



Diseases related to bone osteosarcoma

Clinical Features for Bone Osteosarcoma

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Drugs & Therapeutics for Bone Osteosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bone Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Bone Osteosarcoma

Search NIH Clinical Center for Bone Osteosarcoma

Search CenterWatch for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

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Anatomical Context for Bone Osteosarcoma

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32MalaCards
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MalaCards organs/tissues related to Bone Osteosarcoma:

32
Bone, Liver, Kidney, Bone marrow, Prostate, T cells

Animal Models for Bone Osteosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bone Osteosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.7NKX3-2, SNAI2, TNFRSF11A
2MP:00053798.6TNFRSF11A, SNAI2, NKX3-2
3MP:00053908.6NKX3-2, SNAI2, TNFRSF11A
4MP:00053978.5TNFRSF11A, SNAI2, NKX3-2
5MP:00053788.5NKX3-2, SNAI2, TNFRSF11A
6MP:00053878.4NKX3-2, SNAI2, TNFRSF11A
7MP:00053848.2TNFRSF11A, SNAI2, NKX3-2

Publications for Bone Osteosarcoma

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50PubMed
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Articles related to Bone Osteosarcoma:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Bone morphogenetic protein 9 regulates tumor growth of osteosarcoma cells through the Wnt/I^-catenin pathway. (24337584)
2014
2
Increased invasiveness of osteosarcoma mesenchymal stem cells induced by bone-morphogenetic protein-2. (23519562)
2013
3
Osteosarcoma pulmonary metastasis mimicking abnormal skeletal uptake in bone scan: utility of SPECT/CT. (23486324)
2013
4
Osteosarcoma After Bone Marrow Transplantation: Still a Challenge. (23929319)
2013
5
Fibrocartilaginous intramedullary bone forming tumor of the distal femur mimicking osteosarcoma. (23580060)
2013
6
The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors. (22367914)
2012
7
Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice. (22550000)
2012
8
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. (21336260)
2011
9
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. (17671200)
2007
10
Expression of cyclooxygenase-2 in osteosarcoma of bone. (17536311)
2007
11
Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. (16533764)
2006
12
Primary bone osteosarcoma in the pediatric age: state of the art. (16860938)
2006
13
Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature. (16434839)
2006
14
Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. (16475708)
2006
15
RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells. (16328004)
2006
16
Doxorubicin and cisplatin chemotherapy in high-grade spindle cell sarcomas of the bone, other than osteosarcoma or malignant fibrous histiocytoma: a European Osteosarcoma Intergroup Study. (15661546)
2005
17
Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. (16087680)
2005
18
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. (15540465)
2004
19
A phase II study of cisplatin, doxorubicin, and ifosfamide with peripheral blood stem cell support in patients with skeletal osteosarcoma and variant bone tumors with a poor prognosis. (15222001)
2004
20
Biochemical bone resorption markers in children with osteosarcoma]. (15738598)
2004
21
A fatal case of pleural osteosarcoma mimicking mesothelioma in Paget's disease of bone. (14645873)
2003
22
ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. (12569382)
2003
23
Modification of gene expression induced in human osteogenic and osteosarcoma cells by culture on a biphasic calcium phosphate bone substitute. (12810167)
2003
24
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. (12181274)
2002
25
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. (11351498)
2001
26
Inheritance of osteosarcoma and Paget's disease of bone: a familial loss of heterozygosity study. (11687601)
2001
27
The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures. (10716620)
2000
28
Sex steroids and bone metabolism: comparison of in vitro effects of 17beta-estradiol and testosterone on human osteosarcoma cell lines of various gender and differentiation. (11026755)
2000
29
Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. (10977962)
2000
30
Neoadjuvant chemotherapy with doxorubicin and cisplatin in malignant fibrous histiocytoma of bone: A European Osteosarcoma Intergroup study. (10506628)
1999
31
1,25-Dihydroxyvitamin D3, recombinant human transforming growth factor-beta 1, and recombinant human bone morphogenetic protein-2 induce in vitro differentiation of canine osteosarcoma cells. (10423687)
1999
32
Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone. (9718349)
1998
33
Osteosarcoma of the maxilla in a case of Paget's disease of bone. (9043011)
1997
34
Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors. (9426330)
1997
35
Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone. (18521214)
1997
36
Low rates of Paget's disease of bone and osteosarcoma in elderly Japanese. (8684133)
1996
37
Expression of bone morphogenetic proteins by osteoinductive and non-osteoinductive human osteosarcoma cells. (8876605)
1996
38
Human osteosarcoma (OST) induces mouse reactive bone formation in xenograft system. (8922642)
1996
39
In vivo implantation of human osteosarcoma cells in nude mice induces bones with human-derived osteoblasts and mouse-derived osteocytes. (8941216)
1996
40
Cauda equina syndrome caused by osteosarcoma in a patient with Paget's disease of bone: value of modern imaging. (8869226)
1995
41
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. (8625223)
1995
42
MR imaging of bone marrow in children with osteosarcoma: effect of granulocyte colony-stimulating factor. (7545864)
1995
43
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding. (7976302)
1994
44
Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. (7506120)
1994
45
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. (7503935)
1993
46
Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. (8418091)
1993
47
Purification and partial identification of bone-inducing protein from a murine osteosarcoma. (1320380)
1992
48
Regulation of osteocalcin secretion by human primary bone cells and by the human osteosarcoma cell line MG-63. (1657256)
1991
49
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. (6930319)
1980
50
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970

Genetic Variations for Bone Osteosarcoma

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Expression for genes affiliated with Bone Osteosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Osteosarcoma

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Pathways for genes affiliated with Bone Osteosarcoma

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Compounds for genes affiliated with Bone Osteosarcoma

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GO Terms for genes affiliated with Bone Osteosarcoma

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16Gene Ontology
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Biological processes related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of chondrocyte differentiationGO:0323319.0NKX3-2, SNAI2

Molecular functions related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0NKX3-2, SNAI2

Products for genes affiliated with Bone Osteosarcoma

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Sources for Bone Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet