MCID: BNS001
MIFTS: 31

Bone Osteosarcoma malady

Bone diseases category

Summaries for Bone Osteosarcoma

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32MalaCards
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MalaCards: Bone Osteosarcoma, also known as osteosarcoma of bone, is related to osteosarcoma and paget's disease of bone. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 homeobox 2). Affiliated tissues include bone, liver and kidney, and related mouse phenotypes are craniofacial and endocrine/exocrine gland.

Aliases & Classifications for Bone Osteosarcoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

bone osteosarcoma 8
osteosarcoma of bone 8 60
primary osteosarcoma of bone 8


External Ids:

Disease Ontology8 DOID:3376
SNOMED-CT56 307576001
NCIt39 C53707

Related Diseases for Bone Osteosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.5TNFRSF11A
2paget's disease of bone10.1
3fibrous dysplasia10.0
4localized osteosarcoma10.0
5osteopoikilosis10.0
6bone giant cell tumor10.0
7chondrosarcoma10.0
8fibrosarcoma10.0
9giant cell tumor10.0
10malignant giant cell tumor10.0
11pediatric osteosarcoma10.0

Graphical network of diseases related to Bone Osteosarcoma:



Diseases related to bone osteosarcoma

Clinical Features for Bone Osteosarcoma

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Drugs & Therapeutics for Bone Osteosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Bone Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Bone Osteosarcoma

Search NIH Clinical Center for Bone Osteosarcoma

Search CenterWatch for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

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Anatomical Context for Bone Osteosarcoma

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32MalaCards
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MalaCards organs/tissues related to Bone Osteosarcoma:

32
Bone, Liver, Kidney, Bone marrow, Prostate, T cells

Animal Models for Bone Osteosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bone Osteosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.7NKX3-2, SNAI2, TNFRSF11A
2MP:00053798.6TNFRSF11A, SNAI2, NKX3-2
3MP:00053908.6NKX3-2, SNAI2, TNFRSF11A
4MP:00053978.5TNFRSF11A, SNAI2, NKX3-2
5MP:00053788.5NKX3-2, SNAI2, TNFRSF11A
6MP:00053878.4NKX3-2, SNAI2, TNFRSF11A
7MP:00053848.2TNFRSF11A, SNAI2, NKX3-2

Publications for Bone Osteosarcoma

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50PubMed
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Articles related to Bone Osteosarcoma:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005. (24425828)
2014
2
Association between absolute tumor burden and serum bone-specific alkaline phosphatase in canine appendicular osteosarcoma. (23734720)
2013
3
Bone formation induced by BMP-2 in human osteosarcoma cells. (23900689)
2013
4
In vitro delivery and controlled release of Doxorubicin for targeting osteosarcoma bone cancer. (23999729)
2013
5
Giant cell-rich osteosarcoma in long bones: clinical, radiological and pathological features. (23716292)
2013
6
Radiographically Occult Latent Radiogenic Osteosarcoma Uncovered on Tc-99m Methylene-diphosphonate Bone Scintigraphy. (24228214)
2013
7
Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. (21207222)
2011
8
Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma. (20090505)
2010
9
Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. (19596932)
2009
10
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. (19492781)
2009
11
Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. (19885603)
2009
12
Bone biology and physiology: implications for novel osteoblastic osteosarcoma treatments? (17683874)
2008
13
Long bone florid reactive periostitis ossificans: a case in the distal femur mimicking osteosarcoma. (18841064)
2008
14
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption. (17671200)
2007
15
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
16
Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. (16971354)
2006
17
Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin beta1 into lipid rafts. (17022972)
2006
18
Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium. (16674304)
2006
19
Osteosarcoma in Paget's disease of bone. (17229010)
2006
20
An unusual case of juxtacortical osteosarcoma presenting on Tc-99m MDP bone scan with central photopenia. (14734911)
2004
21
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. (15792374)
2004
22
Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone/kidney alkaline phosphatase gene. (15050898)
2004
23
A fatal case of pleural osteosarcoma mimicking mesothelioma in Paget's disease of bone. (14645873)
2003
24
A rare tumor of craniofacial bones in children: a pediatric chondroblastic osteosarcoma case with diagnostic and therapeutic problems. (11255734)
2001
25
Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. (11797833)
2001
26
Gsalpha gene mutations in monostotic fibrous dysplasia of bone and fibrous dysplasia-like low-grade central osteosarcoma. (11561757)
2001
27
Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. (11169148)
2001
28
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. (10814523)
2000
29
Expression of bone morphogenetic protein and its receptors in osteosarcoma and malignant fibrous histiocytoma. (10939432)
2000
30
Bone matrix production in osteosarcoma]. (10095426)
1998
31
Purification and characterization of bone-specific alkaline phosphatase from a human osteosarcoma cell line. (9405736)
1998
32
P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. (9228255)
1997
33
Neoadjuvant chemotherapy for malignant fibrous histiocytoma of bone and for osteosarcoma of the limbs: a comparison between the results obtained for 21 and 144 patients, respectively, treated during the same period with the same chemotherapy protocol. (8968117)
1996
34
Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. (8992882)
1996
35
1,25-Dihydroxyvitamin D3 and transforming growth factor-beta act synergistically to override extinction of liver/bone/kidney alkaline phosphatase in osteosarcoma hybrid cells. (8682172)
1996
36
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. (8625223)
1995
37
The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. (7641470)
1995
38
Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. (7789337)
1995
39
Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. (8750062)
1995
40
Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. (7826985)
1994
41
Picomolar norethindrone in vitro stimulates the cell proliferation and activity of a human osteosarcoma cell line and increases bone collagen synthesis without an effect on bone resorption. (8053399)
1994
42
Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta. (8040311)
1994
43
Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. (7683966)
1993
44
Immunohistochemical localization of bone Gla protein and osteonectin in normal human bone and cartilage tissues, and in osteosarcomas and chondrosarcomas]. (8336066)
1993
45
Purification and characterization of a bone-inducing protein from a murine osteosarcoma (Dunn type). (8519128)
1993
46
Detection of bone-type alkaline phosphatase by monoclonal antibodies reacting with human osteosarcoma-associated antigen. (1715340)
1991
47
Identification of a bone sialoprotein receptor in osteosarcoma cells. (2461939)
1988
48
Microspectrophotometric quantitation of DNA in bone tumors with giant cells (osteoclastoma, osteosarcoma and chondroblastoma). (6939515)
1981
49
Computed tomography of long-bone osteosarcoma. (286376)
1979
50
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. (1071090)
1976

Genetic Variations for Bone Osteosarcoma

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Expression for genes affiliated with Bone Osteosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for genes affiliated with Bone Osteosarcoma

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Compounds for genes affiliated with Bone Osteosarcoma

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GO Terms for genes affiliated with Bone Osteosarcoma

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16Gene Ontology
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Biological processes related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of chondrocyte differentiationGO:0323319.0NKX3-2, SNAI2

Molecular functions related to Bone Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.0NKX3-2, SNAI2

Products for genes affiliated with Bone Osteosarcoma

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Sources for Bone Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet