Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 14
Bone Resorption 42


External Ids:

Disease Ontology 12 DOID:0080011
MeSH 42 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteoporosis and osteitis fibrosa. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein). The drugs Isosorbide Dinitrate and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and prostate.

Wikipedia : 72 Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 osteoporosis 10.8
2 osteitis fibrosa 10.8

Symptoms & Phenotypes for Bone Resorption Disease

Drugs & Therapeutics for Bone Resorption Disease

Drugs for Bone Resorption Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 272)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
Nitric Oxide Approved Phase 4 10102-43-9 145068
3 sodium fluoride Approved Phase 4 7681-49-4
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2 52232-67-4 16133850
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
Potassium Citrate Approved, Vet_approved Phase 4
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 615258-40-7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
Ribavirin Approved Phase 4 36791-04-5 37542
13 Strontium ranelate Approved Phase 4,Phase 2 135459-87-9
Etidronic acid Approved Phase 4,Phase 3,Phase 1 7414-83-7, 2809-21-4 3305
Alginic acid Approved, Experimental Phase 4 9005-32-7
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
Infliximab Approved Phase 4 170277-31-3
Methotrexate Approved Phase 4,Phase 1 1959-05-2, 59-05-2 126941
Adalimumab Approved Phase 4 331731-18-1 16219006
Desogestrel Approved Phase 4 54024-22-5 40973
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1406-16-2
Menadione Approved, Nutraceutical Phase 4,Phase 3 58-27-5 4055
Phytonadione Approved, Nutraceutical Phase 4,Phase 3 84-80-0 4812 5284607
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
leucovorin Approved, Nutraceutical Phase 4,Phase 1 58-05-9 143 6006
30 Menatetrenone Investigational Phase 4 863-61-6
31 diuretics Phase 4
32 Isosorbide Phase 4
33 isosorbide-5-mononitrate Phase 4
34 Natriuretic Agents Phase 4
35 Nitric Oxide Donors Phase 4
36 Vasodilator Agents Phase 4,Phase 3,Phase 1
37 Listerine Phase 4
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
39 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
40 Dipeptidyl-Peptidase IV Inhibitors Phase 4
41 HIV Protease Inhibitors Phase 4
42 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
43 Hormones Phase 4,Phase 2,Phase 3,Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
45 Hypoglycemic Agents Phase 4
46 Incretins Phase 4
protease inhibitors Phase 4
48 Sitagliptin Phosphate Phase 4
49 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Diphosphonates Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 238)

id Name Status NCT ID Phase Drugs
1 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
2 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
3 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Unknown status NCT01603693 Phase 4
4 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
5 The Effects of Potassium Citrate on Bone Metabolism Completed NCT00357331 Phase 4 potassium citrate
6 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
7 The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty Completed NCT02760979 Phase 4 Denosumab;Placebo
8 Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption Completed NCT01750086 Phase 4 Teriparatide 40-mcg subcutaneous injection;Denosumab Injection;Alendronate Oral Tablet
9 Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption? Completed NCT00766532 Phase 4 Aromatase Inhibitor
10 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
11 A Study of Bone Turnover Markers in Post-Menopausal Women With Osteoporosis Treated With Monthly Boniva (Ibandronate) Completed NCT00303485 Phase 4 Placebo;Vitamin D and calcium supplementation;ibandronate [Bonviva/Boniva]
12 Study of Effects of Tenofovir on Bone Health and Kidneys During Pregnancy and Breastfeeding Completed NCT01066858 Phase 4 Tenofovir disoproxil fumarate (TDF)
13 Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer Completed NCT00219271 Phase 4 Zoledronic acid
14 The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss Completed NCT00460057 Phase 4 Alendronate
15 Influence of Antiviral Therapy on Bone Mineral Density and Metabolism in Patients With Chronic Hepatitis C Completed NCT00948220 Phase 4 peginterferon alfa-2a and ribavirin
16 Effect of Full Length Parathyroid Hormone, PTH(1-84) or Strontium Ranelate on Bone Markers in Postmenopausal Women With Primary Osteoporosis (FP-006-IM) Completed NCT00479037 Phase 4 Full Length Parathyroid Hormone, PTH(1-84);Strontium Ranelate
17 Enhancing Osteoporosis Therapy: Can We Open the Anabolic Window? Completed NCT01166958 Phase 4 Teriparatide;Raloxifene
18 POWER Point of Care Effect on Satisfaction of Treatment Completed NCT00549068 Phase 4 Risedronate Sodium (Actonel)
19 The Effect of Vitamin K2 on Bone Turnover Completed NCT00548509 Phase 4 Menatetrenone (Vitamin K2)
20 Combined Administration of Teripapartide and Antiresorptive Agents in Postmenopausal Osteoporosis Completed NCT01535027 Phase 4 teriparatide;teriparatide and raloxifene;teriparatide and alendronate
21 Bone Loss in Premenopausal Women With Depression Completed NCT00006180 Phase 4 Alendronate
22 Risedronate Sodium in Post Menopausal Osteoporosis Completed NCT00453492 Phase 4 risedronate sodium
23 Bone Mineral Changes Around Stemless and Stemmed Cementless Femoral Components Completed NCT00957970 Phase 4
24 A Study Comparing Monthly Boniva (Ibandronate) and Weekly Risedronate in Women With Post-Menopausal Osteoporosis. Completed NCT00377234 Phase 4 Risedronate;ibandronate [Bonviva/Boniva]
25 Study on Regenerative Treatment of Intra-bony Defects Completed NCT00757159 Phase 4
26 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed NCT00582972 Phase 4 Omeprazole
27 Gene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid Arthritis Completed NCT00213564 Phase 4 response to infliximab associated with methotrexate
28 Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfecta Completed NCT02303873 Phase 4 Alendronate
29 Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy Completed NCT00485953 Phase 4 risedronate
30 Prolonged Protection From Bone Disease in Multiple Myeloma Recruiting NCT02286830 Phase 4 Zoledronic acid
31 Alveolar Management Following Teeth Extraction Recruiting NCT03089619 Phase 4 Human-Spongiosa
32 Bone Resorption, Osteoclastogenesis and Adalimumab Recruiting NCT02035800 Phase 4 Adalimumab
33 Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis Recruiting NCT03087851 Phase 4 Zoledronic Acid
34 Assessing the Impact of Contraceptives on Bone Health Using 41Ca Active, not recruiting NCT02367846 Phase 4 Combined Oral Contraceptive (COC);Contraceptive Vaginal Ring (CVR)
35 Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium Terminated NCT01806974 Phase 4
36 Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist Terminated NCT01381926 Phase 4 exenatide;Saline
37 The Effects of Alendronate After Cure of Primary Hyperparathyroidism Withdrawn NCT00359385 Phase 4 Alendronate 70mg weekly
38 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
39 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3 osteoanabolic therapy
40 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
41 Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects Completed NCT02982681 Phase 3 Platelet rich fibrin;Bioactive Glass
42 Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis Completed NCT02283515 Phase 2, Phase 3 Rosuvastatin
43 Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women Completed NCT00330096 Phase 3 Hesperidin
44 The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis Completed NCT00252421 Phase 3 Nitroglycerin ointment 15 mg/day daily for 24 month;Placebo ointment daily for 24 month
45 Pamidronate Prophylaxis in Multiple Myeloma 30 mg/Month Versus 90 mg/Month Completed NCT00376883 Phase 3 pamidronate
46 Pamidronate to Treat Osteogenesis Imperfecta in Children Completed NCT00005901 Phase 3 Pamidronate (Aredia)
47 Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation Completed NCT00297830 Phase 2, Phase 3 Zoledronic acid;Alendronate
48 Zoledronic Acid in the Prevention of Bone Loss in Postmenopausal Women With Osteopenia, 45 Years of Age and Older Completed NCT00132808 Phase 3 Zoledronic Acid;Placebo
49 Vascular and Skeletal Protective Effects of Genistein in Postmenopausal Women Completed NCT00355953 Phase 2, Phase 3 Genistein
50 Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy Completed NCT00172055 Phase 3 Zoledronic acid

Search NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

Bone, Breast, Prostate, Bone Marrow, Kidney, Endothelial, Spinal Cord

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

id Title Authors Year
[The OPG/RANKL/RANK system and bone resorptive disease]. ( 15971575 )

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

GO Terms for Bone Resorption Disease

Sources for Bone Resorption Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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