MCID: BNR002
MIFTS: 33

Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 14
Bone Resorption 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0080011
MeSH 41 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteitis fibrosa and osteoporosis. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and RANK Signaling in Osteoclasts. Affiliated tissues include bone, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Bone reabsorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 osteitis fibrosa 32.2 BGLAP CALCA PTH
2 osteoporosis 28.4 ACP5 BGLAP BMP2 CALCA CTSK ESR1
3 axial osteomalacia 10.7 BGLAP PTH
4 extraskeletal chondroma 10.6 BGLAP PTH
5 fibrogenesis imperfecta ossium 10.6 CALCA PTH TNFRSF11B
6 pseudoarthrosis 10.6 BMP2 PTH
7 hypophosphatasia, adult 10.6 BGLAP CALCA PTH
8 osteopetrosis, autosomal dominant 2 10.6 BGLAP TNFSF11
9 impaired renal function disease 10.6 BGLAP PTH SOST
10 kummell's disease 10.6 SOST TNFRSF11B TNFSF11
11 multicentric reticulohistiocytosis 10.5 TNFRSF11B TNFSF11
12 breast leiomyosarcoma 10.5 TNFRSF11A TNFSF11
13 hypercalcemia, infantile, 1 10.5 CALCA PTH VDR
14 sclerosteosis 1 10.5 SOST SP7
15 parathyroid adenoma 10.5 BGLAP CALCA PTH
16 spondyloarthropathy 1 10.5 BGLAP TNFRSF11B TNFSF11
17 idiopathic hypercalciuria 10.5 BGLAP TNFSF11 VDR
18 villonodular synovitis 10.5 ACP5 TNFSF11
19 adamantinoma of long bones 10.5 BGLAP SP7 TNFSF11
20 bone giant cell tumor 10.5 ACP5 CALCA CTSK
21 periodontitis, chronic 10.5 TNFRSF11B TNFSF11
22 polyarticular onset juvenile idiopathic arthritis 10.5 TNFRSF11A TNFRSF11B TNFSF11
23 hypercementosis 10.5 ACP5 CTSK SOST
24 hemophilic arthropathy 10.5 TNFRSF11A TNFRSF11B TNFSF11
25 osteomalacia 10.5 BGLAP CALCA VDR
26 familial expansile osteolysis 10.5 TNFRSF11A TNFRSF11B TNFSF11
27 ossification of the posterior longitudinal ligament of spine 10.5 BGLAP BMP2 RUNX2
28 protrusio acetabuli 10.5 ESR1 VDR
29 aneurysmal bone cysts 10.5 CALCA TNFRSF11A TNFSF11
30 chronic apical periodontitis 10.5 TNFRSF11B TNFSF11
31 hyperphosphatemia 10.5 PTH RUNX2 VDR
32 osseous heteroplasia, progressive 10.5 BGLAP BMP2 RUNX2
33 osteoporotic fracture 10.5 ESR1 TNFRSF11B
34 fibrous dysplasia 10.5 BGLAP CALCA IGF1
35 uremia 10.4 PTH TNFRSF11B VDR
36 thyroid gland disease 10.4 CALCA IGF1 PTH
37 craniodiaphyseal dysplasia 10.4 CALCA LRP5 SOST
38 parathyroid gland disease 10.4 BGLAP CALCA PTH VDR
39 degenerative disc disease 10.4 BMP2 CALCA VDR
40 osteogenesis imperfecta, type i 10.4 BGLAP IGF1 TNFRSF11B
41 mineral metabolism disease 10.4 BGLAP CALCA PTH VDR
42 periodontitis 10.4 BGLAP CTSK TNFRSF11B TNFSF11
43 camurati-engelmann disease 10.4 ACP5 BGLAP LRP5
44 aortic valve disease 1 10.4 BMP2 RUNX2 TNFRSF11B
45 rickets 10.4 BGLAP PTH VDR
46 primary hyperparathyroidism 10.4 BGLAP CALCA PTH VDR
47 spondylosis 10.4 ESR1 PTH VDR
48 tooth ankylosis 10.4 BMP2 TNFSF11
49 cohen-gibson syndrome 10.4 BGLAP TNFRSF11A TNFRSF11B TNFSF11
50 van buchem disease 10.4 LRP5 SOST VDR

Graphical network of the top 20 diseases related to Bone Resorption Disease:



Diseases related to Bone Resorption Disease

Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 TNFRSF11A TRPV1 VDR TNFRSF11B BMP2 IGF1
2 growth/size/body region MP:0005378 10.33 TNFRSF11A TRPV1 VDR TNFRSF11B TNFSF11 BMP2
3 cardiovascular system MP:0005385 10.28 TRPV1 VDR TNFRSF11B BMP2 IGF1 LRP5
4 homeostasis/metabolism MP:0005376 10.25 SP7 TNFSF11 TNFRSF11A TRPV1 VDR BMP2
5 craniofacial MP:0005382 10.21 TNFRSF11A VDR TNFRSF11B TNFSF11 BMP2 CTSK
6 hematopoietic system MP:0005397 10.21 TNFSF11 TNFRSF11A VDR TNFRSF11B BMP2 IGF1
7 immune system MP:0005387 10.21 TNFSF11 TNFRSF11A TRPV1 VDR TNFRSF11B BMP2
8 endocrine/exocrine gland MP:0005379 10.13 TNFSF11 TNFRSF11A VDR ESR1 IGF1 CTSK
9 limbs/digits/tail MP:0005371 10.13 TNFRSF11A VDR TNFRSF11B TNFSF11 IGF1 CTSK
10 digestive/alimentary MP:0005381 10.04 TNFRSF11A VDR ESR1 BMP2 CTSK NFATC1
11 integument MP:0010771 9.97 TNFSF11 TNFRSF11A TRPV1 VDR ESR1 IGF1
12 mortality/aging MP:0010768 9.97 SP7 TNFSF11 TNFRSF11A VDR TNFRSF11B ESR1
13 respiratory system MP:0005388 9.56 SP7 TNFSF11 TNFRSF11A ESR1 IGF1 CTSK
14 skeleton MP:0005390 9.5 TNFRSF11A VDR TNFRSF11B TNFSF11 IGF1 CTSK

Drugs & Therapeutics for Bone Resorption Disease

Search Clinical Trials , NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

38
Bone

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

# Title Authors Year
1
[The OPG/RANKL/RANK system and bone resorptive disease]. ( 15971575 )
2003

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

Pathways related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 IGF1 TNFRSF11A TNFRSF11B TNFSF11 TRPV1
2
Show member pathways
12.28 ACP5 CTSK NFATC1 TNFRSF11A TNFRSF11B TNFSF11
3 11.95 ACP5 CTSK NFATC1 TNFRSF11A TNFRSF11B TNFSF11
4 11.69 ACP5 CTSK TNFRSF11A TNFSF11
5 11.62 BGLAP BMP2 IGF1 PTH RUNX2 SP7
6
Show member pathways
11.61 TNFRSF11A TNFRSF11B TNFSF11
7 11.57 ESR1 RUNX2 VDR
8 11.47 IGF1 PTH RUNX2
9 11.25 BGLAP PTH RUNX2 TNFSF11 VDR
10 10.93 BGLAP CALCA IGF1 PTH RUNX2 TNFRSF11A
11 10.77 BGLAP PTH TNFRSF11B TNFSF11
12 10.56 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
13 10.49 PTH VDR

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP BMP2 CALCA CTSK IGF1 PTH
2 extracellular space GO:0005615 9.28 BGLAP BMP2 CALCA CTSK IGF1 PTH

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.97 BMP2 CALCA IGF1 PTH TNFRSF11B TNFSF11
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 BMP2 ESR1 IGF1 LRP5 NFATC1 RUNX2
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 ESR1 LRP5 TNFRSF11A TNFSF11
5 cellular calcium ion homeostasis GO:0006874 9.81 CALCA PTH VDR
6 osteoblast differentiation GO:0001649 9.81 BGLAP BMP2 RUNX2 SP7
7 response to estrogen GO:0043627 9.79 BGLAP ESR1 TNFRSF11B
8 positive regulation of osteoblast differentiation GO:0045669 9.78 BMP2 IGF1 RUNX2
9 cellular response to growth factor stimulus GO:0071363 9.77 BGLAP BMP2 TRPV1
10 response to heat GO:0009408 9.75 CALCA IGF1 TRPV1
11 monocyte chemotaxis GO:0002548 9.73 CALCA TNFRSF11A TNFSF11
12 regulation of osteoclast differentiation GO:0045670 9.65 BGLAP TNFSF11
13 positive regulation of glycogen biosynthetic process GO:0045725 9.65 IGF1 PTH
14 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.64 CALCA TRPV1
15 response to inorganic substance GO:0010035 9.64 BGLAP TNFRSF11B
16 negative regulation of bone resorption GO:0045779 9.63 CALCA TNFRSF11B
17 positive regulation of osteoblast proliferation GO:0033690 9.62 BMP2 LRP5
18 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.62 BMP2 RUNX2
19 mammary gland alveolus development GO:0060749 9.61 ESR1 TNFRSF11A TNFSF11
20 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.58 BMP2 RUNX2
21 osteoblast development GO:0002076 9.58 BGLAP LRP5 RUNX2
22 bone mineralization involved in bone maturation GO:0035630 9.57 BMP2 IGF1
23 bone resorption GO:0045453 9.56 ACP5 CTSK PTH TNFSF11
24 TNFSF11-mediated signaling pathway GO:0071847 9.55 TNFRSF11A TNFSF11
25 mammary gland branching involved in pregnancy GO:0060745 9.54 ESR1 VDR
26 positive regulation of ossification GO:0045778 9.5 BMP2 CALCA PTH
27 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.48 TNFRSF11A TNFSF11
28 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.46 TNFRSF11A TNFSF11
29 ossification GO:0001503 9.43 BGLAP BMP2 RUNX2 SOST TNFRSF11A TNFSF11
30 skeletal system development GO:0001501 9.17 BGLAP BMP2 IGF1 PTH RUNX2 TNFRSF11B
31 inflammatory response GO:0006954 10 BMP2 CALCA TNFRSF11A TNFRSF11B TRPV1

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA IGF1 PTH

Sources for Bone Resorption Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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