MCID: BNS002
MIFTS: 36

Bone Structure Disease

Categories: Bone diseases

Aliases & Classifications for Bone Structure Disease

MalaCards integrated aliases for Bone Structure Disease:

Name: Bone Structure Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0080010

Summaries for Bone Structure Disease

Disease Ontology : 12 A bone disease that has material basis in an abnormality in the location or function of the skeletal structure.

MalaCards based summary : Bone Structure Disease is related to spondylolisthesis and smooth muscle tumor. An important gene associated with Bone Structure Disease is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are Degradation of the extracellular matrix and Spinal Cord Injury. The drugs Ethanol and Heparin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are limbs/digits/tail and skeleton

Related Diseases for Bone Structure Disease

Graphical network of the top 20 diseases related to Bone Structure Disease:



Diseases related to Bone Structure Disease

Symptoms & Phenotypes for Bone Structure Disease

MGI Mouse Phenotypes related to Bone Structure Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.56 ADAMTS5 BMP2 COL2A1 GDF5 LBX1 MMP13
2 skeleton MP:0005390 9.32 ADAMTS5 BMP2 COL2A1 GDF5 MMP13 MMP3

Drugs & Therapeutics for Bone Structure Disease

Drugs for Bone Structure Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1418)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
2
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 772 46507594
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
4
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
6
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
7
Fenofibrate Approved Phase 4,Phase 3,Phase 1 49562-28-9 3339
8
Simvastatin Approved Phase 4,Phase 3,Phase 1,Phase 2 79902-63-9 54454
9
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
10
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
12
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 58-22-0 6013
13
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 65271-80-9 4212
14
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757
15
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
16
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
17
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
18
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
19
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
20
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
21
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
22
Rifampin Approved Phase 4,Phase 3,Phase 2 13292-46-1 5458213 5381226
23
Tamoxifen Approved Phase 4,Phase 3,Phase 2,Phase 1 10540-29-1 2733526
24
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2 154598-52-4 64139
25
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-43-4 5816
26
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
27
Nicardipine Approved Phase 4 55985-32-5 4474
28
Toremifene Approved, Investigational Phase 4,Phase 3,Phase 2 89778-26-7 3005573
29
Iron Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 7439-89-6 23925
30
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1 30516-87-1 35370
31
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
32
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
33
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
34
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
35
Cimetidine Approved Phase 4,Phase 2 51481-61-9 2756
36
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
37
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 134678-17-4 60825
38
Celecoxib Approved, Investigational Phase 4,Phase 2,Phase 1 169590-42-5 2662
39
Hydroxyurea Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 127-07-1 3657
40
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
41
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
42
Isosorbide Dinitrate Approved Phase 4,Phase 3 87-33-2 6883
43
Acetylcholine Approved Phase 4,Phase 3 51-84-3 187
44
Alendronate Approved Phase 4,Phase 2,Phase 3,Phase 1 121268-17-5, 66376-36-1 2088
45
Tibolone Approved Phase 4,Phase 3,Phase 2,Phase 1 5630-53-5
46
Goserelin Approved Phase 4,Phase 3,Phase 2,Phase 1 65807-02-5 47725 5311128
47
Vidarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 24356-66-9 32326 21704
48
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
49
Ribavirin Approved Phase 4,Phase 3,Phase 2 36791-04-5 37542
50
Histamine Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774

Interventional clinical trials:

(show top 50) (show all 9671)

id Name Status NCT ID Phase Drugs
1 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
2 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4 zoledronic acid;sodium chloride
3 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
4 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4 Calcitriol;placebo
5 Pilot Study Evaluating Doxercalciferol Replacement Therapy in Kidney Transplant Recipients Unknown status NCT00889629 Phase 4 Doxercalciferol;placebo
6 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
7 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Unknown status NCT02182843 Phase 4
8 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
9 Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J) Unknown status NCT00974493 Phase 4 Antibiotics
10 Efficacy and Safety of SurgiFill™ on Spinal Fusion Unknown status NCT02466048 Phase 4
11 Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease Unknown status NCT00364884 Phase 4 ketoaminoacid
12 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
13 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Unknown status NCT01603693 Phase 4
14 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
15 Different Doses of Anti-thymocyte Globin to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
16 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
17 Sternal Closure With Biologic Bone Cement in Patients Undergoing Coronary Artery Bypass Grafting (CABG) Unknown status NCT01261858 Phase 4
18 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
19 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
20 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
21 A Study Comparing Outcomes of Kidney Transplants in Patients on Steroids Versus Those Who Discontinue Steroids Unknown status NCT00273559 Phase 4 prednisone
22 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
23 A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD) Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
24 Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components Unknown status NCT01180595 Phase 4
25 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
26 This is a 2 Year Follow up Clinical and Radiographic Analysis of a Novel All Polyethelene Glenoid Component in Standard Total Shoulder Arthroplasty. Unknown status NCT01313741 Phase 4
27 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole
28 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
29 Multi-centre Clinical Trial on Hormone Replacement Treatment in China Unknown status NCT01698164 Phase 4 estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
30 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4 Vitamin D drops;Placebo drops
31 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
32 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
33 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4 Vitamin D3
34 Treatment Protocol of Child SAA With the Injection of Mesenchymal Stem Cells(Umbilical Cord Derived) Unknown status NCT02218437 Phase 4 MSC+ATG
35 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
36 Effects of Omega-3 Fatty Acids on Bone and Frailty Unknown status NCT00634686 Phase 4
37 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
38 Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes Unknown status NCT01153243 Phase 4 Ergocalciferol;Placebo pill
39 Demineralized Bone Matrix in Opening Wedge Osteotomy for Hallux Valgus Deformity Unknown status NCT02388438 Phase 4
40 Moderate-dose Cyclophosphamide for Childhood Acquired Aplastic Anemia Unknown status NCT01995331 Phase 4 cyclophosphamide,cyclosporine A
41 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
42 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
43 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
44 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
45 The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study Unknown status NCT01323608 Phase 4 Vitamin D3;Placebo
46 The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers Unknown status NCT01526304 Phase 4
47 Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma Unknown status NCT01249690 Phase 4 Bortezomib,Pirarubicin,Dexamethasone;Thalidomide,Pirarubicin,Dexamethasone
48 Effect of Vitamin D as Adjunctive Therapy in Patients With Pulmonary Evolution Tuberculosis Unknown status NCT02464683 Phase 4
49 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
50 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D

Search NIH Clinical Center for Bone Structure Disease

Genetic Tests for Bone Structure Disease

Anatomical Context for Bone Structure Disease

MalaCards organs/tissues related to Bone Structure Disease:

39
Bone, Bone Marrow, Prostate, Breast, Myeloid, Kidney, T Cells

Publications for Bone Structure Disease

Variations for Bone Structure Disease

Expression for Bone Structure Disease

Search GEO for disease gene expression data for Bone Structure Disease.

Pathways for Bone Structure Disease

GO Terms for Bone Structure Disease

Cellular components related to Bone Structure Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 ACAN ADAMTS5 BMP2 COL2A1 COL9A3 FTH1
2 extracellular space GO:0005615 9.76 ACAN ADAMTS5 BMP2 CILP COL2A1 GDF5
3 collagen trimer GO:0005581 9.5 COL2A1 COL9A3 MMP13
4 extracellular matrix GO:0031012 9.35 ACAN CILP COL2A1 MMP13 MMP3
5 proteinaceous extracellular matrix GO:0005578 9.17 ACAN ADAMTS5 CILP COL2A1 COL9A3 MMP13

Biological processes related to Bone Structure Disease according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 BMP2 FTH1 LBX1 NF1 SOX9
2 heart development GO:0007507 9.85 ACAN BMP2 NF1 SOX9
3 central nervous system development GO:0007417 9.8 ACAN COL2A1 SOX9
4 ossification GO:0001503 9.73 BMP2 COL2A1 SOX9
5 skeletal system development GO:0001501 9.67 ACAN BMP2 COL2A1 SOX9
6 collagen catabolic process GO:0030574 9.65 COL2A1 MMP13 MMP3
7 extracellular matrix organization GO:0030198 9.65 ACAN COL2A1 COL9A3 NF1 SOX9
8 cartilage condensation GO:0001502 9.62 COL2A1 SOX9
9 tissue homeostasis GO:0001894 9.61 COL2A1 SOX9
10 positive regulation of chondrocyte differentiation GO:0032332 9.61 GDF5 SOX9
11 negative regulation of chondrocyte differentiation GO:0032331 9.6 GDF5 SOX9
12 chondrocyte development GO:0002063 9.59 ACAN SOX9
13 positive regulation of cartilage development GO:0061036 9.58 BMP2 SOX9
14 endocardial cushion morphogenesis GO:0003203 9.58 BMP2 SOX9
15 myelination in peripheral nervous system GO:0022011 9.57 NF1 SH3TC2
16 limb bud formation GO:0060174 9.54 COL2A1 SOX9
17 notochord development GO:0030903 9.52 COL2A1 SOX9
18 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.51 BMP2 CILP
19 collagen fibril organization GO:0030199 9.5 ACAN COL2A1 NF1
20 proteoglycan metabolic process GO:0006029 9.46 BMP2 COL2A1
21 extracellular matrix disassembly GO:0022617 9.46 ACAN ADAMTS5 MMP13 MMP3
22 otic vesicle development GO:0071599 9.43 COL2A1 SOX9
23 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.4 GDF5 SOX9
24 chondrocyte differentiation GO:0002062 9.26 BMP2 COL2A1 GDF5 SOX9
25 cartilage development GO:0051216 9.02 BMP2 COL2A1 GDF5 MMP13 SOX9

Molecular functions related to Bone Structure Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 9.13 ADAMTS5 MMP13 MMP3
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL2A1 COL9A3

Sources for Bone Structure Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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52 Novoseek
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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