MCID: BRD005
MIFTS: 32

Borderline Leprosy malady

Categories: Infectious diseases

Aliases & Classifications for Borderline Leprosy

Aliases & Descriptions for Borderline Leprosy:

Name: Borderline Leprosy 12 14 69
Midborderline Leprosy 12 69
Borderline or Dimorphous Leprosy 12
Borderline Leprosy [group B] 12
Leprosy, Borderline 42

Classifications:



External Ids:

Disease Ontology 12 DOID:1023
ICD10 33 A30.3
ICD9CM 35 030.3
MeSH 42 D015439
SNOMED-CT 64 400008009 50521002
UMLS 69 C0023346

Summaries for Borderline Leprosy

Disease Ontology : 12 A leprosy that results in small numerous red irregularly shaped plaques.

MalaCards based summary : Borderline Leprosy, also known as midborderline leprosy, is related to leprosy and discharging ear. An important gene associated with Borderline Leprosy is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are IgA-Producing B Cells in the Intestine and Photodynamic therapy-induced NF-kB survival signaling. The drugs Clofazimine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and mortality/aging

Wikipedia : 71 Borderline leprosy is a cutaneous skin condition with numerous skin lesions that are red irregularly... more...

Related Diseases for Borderline Leprosy

Diseases related to Borderline Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 leprosy 11.0
2 discharging ear 10.1 MLLT1 SDHD
3 streptococcal meningitis 10.1 APOH NOS2
4 chronic erythremia 10.0 CD40LG MLLT1
5 cardiac arrest 10.0 CD40LG SDHD
6 myeloid leukemia 9.9 APOH CD40LG
7 intermediate coronary syndrome 9.9 APOH CD40LG
8 keratomalacia 9.9 CD40LG NOS2
9 carotenemia 9.9 CD40LG SDHD
10 lubinsky syndrome 9.9 APOH CD40LG
11 central congenital hypothyroidism 9.9 APOH CD40LG
12 czech dysplasia 9.9 APOH CD40LG
13 pseudohypoparathyroidism 9.9 APOH CD40LG
14 central retinal artery occlusion 9.9 APOH CD40LG
15 lumbar spinal canal and spinal cord meningioma 9.9 CD40LG SDHD
16 lung combined large cell neuroendocrine carcinoma 9.9 APOH CD40LG
17 macrocephaly with multiple epiphyseal dysplasia and distinctive facies 9.9 APOH CD40LG
18 multinodular goiter 9.9 APOH CD40LG
19 foodborne botulism 9.9 CD40LG MLLT1
20 stiff-person syndrome 9.9 APOH CD40LG
21 sertoli-leydig cell tumor 9.9 APOH CD40LG
22 haemonchiasis 9.8 APOH CD40LG
23 microscopic breast papilloma 9.8 CD40LG NOS2
24 neuritis 9.8
25 respiratory system disease 9.8 APOH CD40LG
26 membranoproliferative glomerulonephritis 9.8 APOH CD40LG
27 eating disorder 9.7 APOH CD40LG
28 lymphadenitis 9.7
29 cheilitis 9.7
30 pulmonary tuberculosis 9.7
31 tuberculosis 9.7
32 hansen's disease 9.7
33 hepatitis 9.7
34 lymphoma 9.7
35 portal hypertension 9.7
36 lepromatous leprosy 9.7
37 urticaria 9.7
38 exhibitionism 9.2 APOH CD40LG KIAA1109 MLLT1 NOS2 SDHD

Graphical network of the top 20 diseases related to Borderline Leprosy:



Diseases related to Borderline Leprosy

Symptoms & Phenotypes for Borderline Leprosy

GenomeRNAi Phenotypes related to Borderline Leprosy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.4 MLLT1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.4 SDHD APOH MLLT1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.4 SDHD
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.4 APOH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.4 SDHD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.4 SDHD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.4 APOH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 MLLT1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.4 MLLT1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 MLLT1

MGI Mouse Phenotypes related to Borderline Leprosy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 APOH CD40LG KIAA1109 MLLT1 NOS2 SDHD

Drugs & Therapeutics for Borderline Leprosy

Drugs for Borderline Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Vitamins Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4

Search NIH Clinical Center for Borderline Leprosy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: leprosy, borderline

Genetic Tests for Borderline Leprosy

Anatomical Context for Borderline Leprosy

MalaCards organs/tissues related to Borderline Leprosy:

39
Skin, Testes, T Cells

Publications for Borderline Leprosy

Articles related to Borderline Leprosy:

(show top 50) (show all 78)
id Title Authors Year
1
Addition of Mycobacterium indicus pranii (MIP) vaccine as an immunotherapeutic with standard chemotherapy in borderline leprosy: A double blind study to assess clinical improvement (A preliminary report). ( 27518926 )
2016
2
Multiple nerve abscesses: An unusual manifestation of lepra reaction in a patient with borderline leprosy. ( 27841214 )
2016
3
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil. ( 25605482 )
2015
4
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. ( 25657399 )
2015
5
Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. ( 25201839 )
2014
6
Tuberculous lymphadenitis and borderline leprosy in a patient with isolated unconjugated hyperbilirubinaemia. ( 25385559 )
2014
7
Mid-borderline leprosy. ( 23741685 )
2013
8
Borderline leprosy masquerading as cheilitis granulomatosa: a case report. ( 23741887 )
2013
9
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. ( 23720894 )
2012
10
Early diagnosis of relapse in borderline leprosy: two case reports. ( 22183459 )
2011
11
A case of borderline leprosy presenting with urticaria-like eruptions: are there lessons to be learned for allergists? ( 21988321 )
2011
12
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. ( 20539766 )
2010
13
Granulomatous slack skin clinically and histologically masquerading as borderline leprosy in its early stages. ( 19171548 )
2009
14
Leprosy serology (ML Flow test) in borderline leprosy patients classified as paucibacillary by counting cutaneous lesions: an useful tool. ( 19618075 )
2008
15
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin. ( 18986365 )
2008
16
Chronic inflammatory joint disease revealing borderline leprosy. ( 16213770 )
2006
17
Guillain-BarrAc syndrome-like presentation in borderline leprosy with type-2 reaction. ( 16638414 )
2006
18
Pitfalls in the cytological classification of borderline leprosy in the Ridley-Jopling scale. ( 15176024 )
2004
19
Nitrotyrosine localization to dermal nerves in borderline leprosy. ( 15030344 )
2004
20
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient. ( 12862258 )
2003
21
Reactions in borderline leprosy. ( 12708730 )
2002
22
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. ( 11736907 )
2001
23
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient. ( 11167702 )
2001
24
Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone. ( 9934360 )
1998
25
beta2-Glycoprotein I-dependent anticardiolipin antibodies as risk factor for reactions in borderline leprosy patients. ( 9934366 )
1998
26
Serial Mitsuda tests for identification of reactional tuberculoid and reactional borderline leprosy forms. ( 9728451 )
1998
27
Immunotherapy of lepromin-negative borderline leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta. ( 9207754 )
1997
28
Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in lesional skin: a follow-up study. ( 9379047 )
1997
29
Case report: cutaneous lymphoma and borderline leprosy simulating lepromatous leprosy. ( 8684256 )
1996
30
Changes of autonomic nerve function in the first two weeks of acute neuritis in a patient with borderline leprosy. ( 8690978 )
1996
31
Generalized rash in a Dominican immigrant. Borderline leprosy (Hansen's disease) with type 1 upgrading (ie, reversal) reaction. ( 8546490 )
1996
32
Pathogenesis of generalized nodular type I reaction in a borderline leprosy patient. ( 7714358 )
1994
33
Phenotype and cytokine expression of intralesional cells in borderline leprosy. ( 7963910 )
1994
34
Scrotal lesion in borderline leprosy. ( 8182293 )
1993
35
Risk factors for type-1 reactions in borderline leprosy patients. ( 1679473 )
1991
36
Additional markers for the type I reactional states of borderline leprosy. ( 2393071 )
1990
37
Scalp lesions in borderline leprosy. ( 2703742 )
1989
38
Late onset of a reversal reaction in borderline leprosy. ( 2654221 )
1989
39
A borderline leprosy lesion on the palate: a case report. ( 3398680 )
1988
40
Type 1 (reversal) lepra reaction in borderline leprosy with unusual clinical presentation--a case report. ( 3655433 )
1987
41
An unusual bullous reaction in borderline leprosy. ( 3298904 )
1987
42
LDH profile in an unusual case of borderline leprosy in reaction associated with portal hypertension. ( 3440847 )
1987
43
Multiple relapses in borderline leprosy--a case report. ( 3553362 )
1986
44
Unilateral oedema of reversal reaction (RR) in borderline leprosy. ( 3784765 )
1986
45
An electron microscopic study on macrophages and lymphocytes in lepromatous and borderline leprosy. ( 3889192 )
1985
46
Immuno-stimulatory effect of levamisole in borderline leprosy cases. ( 3839822 )
1985
47
Borderline leprosy in a three year old child. ( 3831104 )
1985
48
The outpatient treatment of nerve damage in patients with borderline leprosy using a semi-standardized steroid regimen. ( 4021699 )
1985
49
Untreated borderline-leprosy in the ulnar nerve: light and electron microscopical studies. ( 2985898 )
1985
50
Lymphocytic infiltration of skin of Jessner-Kanof masquerading as borderline leprosy. ( 3835210 )
1985

Variations for Borderline Leprosy

Expression for Borderline Leprosy

Search GEO for disease gene expression data for Borderline Leprosy.

Pathways for Borderline Leprosy

Pathways related to Borderline Leprosy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.8 CD40LG NOS2
2
Show member pathways
10.42 CD40LG NOS2

GO Terms for Borderline Leprosy

Molecular functions related to Borderline Leprosy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 NOS2 SDHD

Sources for Borderline Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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